Cc1csc(-c2cc(-c3ccccc3)c3n(c2=O)CCCc2ccncc2-3)n1 CHEMBL44533 Ki 0.3 nM
CCCNC(=O)c1nnc2c(-c3c(F)cccc3OC)cccc2c1N CHEMBL1783282 Ki 0.3 nM
Cc1cc(-c2nnc3c4ccccc4c(OCc4cn(C)nn4)nn23)no1 CHEMBL306422 Ki 0.58 nM
Cc1csc(-c2cc(-c3ccncc3)c3n(c2=O)CCCc2ccncc2-3)n1 CHEMBL45198 Ki 0.6 nM
Cn1ncnc1COc1nn2c(-c3cc(F)ccc3F)nnc2cc1C(C)(C)C CHEMBL373250 Ki 0.7 nM
CCOC(=O)c1ncn2c1CN(C)C(=O)c1cc(F)ccc1-2 CHEMBL407 pKi 0.7943 nM
Cc1cc(-c2nncc3c(C(C)(C)C)c(OCc4ncnn4C)nn23)no1 CHEMBL363211 Ki 0.8 nM
CCOC(=O)c1ncc2[nH]c3ccc(OC)cc3c2c1COC CHEMBL5280240 Ki 1.0 nM
CCCOc1ccc2[nH]c3cnc(C(=O)OCC)c(COC)c3c2c1 CHEMBL49141 Ki 1.0 nM
c1ccc2c(c1)[nH]c1c2ncc2[nH]c3ccccc3c21 CHEMBL301605 Ki 1.0 nM
Fc1ccccc1-n1nc2c(cnc3ccccc32)c1OCc1ccccc1Cl CHEMBL1681887 IC50 2.0 nM
CC(C)(O)c1cnn2c(-c3ccc(F)c(-c4c(F)cccc4C#N)c3)cnc2n1 CHEMBL204696 Ki 2.0 nM
COCc1c(C(=O)OC(C)C)ncc2[nH]c3ccc(OCc4ccccc4)cc3c12 CHEMBL454095 Ki 2.0 nM
CCCNC(=O)c1nnc2c(-c3cnccc3OC)cccc2c1N CHEMBL1783280 pKi 2.239 nM
CCOC(=O)c1ncc2[nH]c3ccccc3c2c1COC CHEMBL5266498 Ki 3.0 nM
O=C1C2C=Nc3ccccc3C2=NN1c1ccc(Cl)cc1 CHEMBL20042 IC50 4.0 nM
CCOC(=O)c1ncc2[nH]c3ccc(OCc4ccccc4)cc3c2c1COC CHEMBL1518572 Ki 4.0 nM
CCCNC(=O)c1nnc2c(-c3cc(OC)ccc3OC)cccc2c1N CHEMBL1783256 Ki 5.0 nM
CCOC(=O)c1cc2c(cn1)[nH]c1ccccc12 CHEMBL454606 Ki 5.0 nM
CCOC(=O)c1ncc2[nH]c3ccc(O)cc3c2c1COC CHEMBL5290464 Ki 5.0 nM
CCn1cnc2c(-c3ccc(F)c(-c4ccc(S(N)(=O)=O)cc4)c3)cnnc21 CHEMBL3647535 Ki 5.08 nM
CCCNC(=O)c1nnc2c(-c3cc(C)ccc3C)cccc2c1N CHEMBL1783247 pKi 5.495 nM
CC(C)n1cnc2c(-c3ccc(F)c(-c4ccc(S(N)(=O)=O)cc4)c3)cnnc21 CHEMBL3647548 Ki 5.82 nM
CCCNC(=O)c1nnc2c(-c3cc(C)ccc3OC)cccc2c1N CHEMBL1783281 pKi 6.166 nM
COC(=O)c1cc2c(cn1)[nH]c1ccccc12 CHEMBL453066 Ki 7.0 nM
CCOC(=O)c1ncn2c1CN(C)C(=O)c1cc(N=[N+]=[N-])ccc1-2 CHEMBL6597 Ki 7.0 nM
CCCNC(=O)c1nnc2c(-c3cnc(OC)nc3OC)cccc2c1N CHEMBL1783279 pKi 7.413 nM
CCn1cnc2c(-c3ccc(F)c(-c4ccc(S(=O)(=O)NC)cc4)c3)cnnc21 CHEMBL3647561 Ki 7.45 nM
CCn1cnc2c(-c3ccc(F)c(-c4ccc(S(C)(=O)=O)cc4OC)c3)cnnc21 CHEMBL3647565 Ki 7.48 nM
CCc1c(C(=O)OC)nc(C)c2[nH]c3cc(OC)c(OC)cc3c12 CHEMBL5290579 Ki 8.0 nM
COc1cc(S(C)(=O)=O)ccc1-c1cc(-c2cnnc3c2ncn3C(C)C)ccc1F CHEMBL3647579 Ki 8.56 nM
CCn1cnc2c(-c3ccc(F)c(-c4ccc(S(=O)(=O)C5CCC5)cc4OC)c3)cnnc21 CHEMBL3647538 Ki 9.51 nM
CCn1cnc2c(-c3ccc(F)c(-c4ccc(S(=O)(=O)C5CC5)cc4OC)c3)cnnc21 CHEMBL3647539 Ki 9.71 nM
COc1ccc(OC)c(-c2cccc3c(N)c(C(=O)NC4CC4)nnc23)c1 CHEMBL1783253 pKi 10.0 nM
CCn1cnc2c(-c3ccc(F)c(-c4ccc(S(C)(=O)=O)cc4F)c3)cnnc21 CHEMBL3647534 Ki 10.9 nM
CCn1cnc2c(-c3ccc(F)c(-c4ccc(S(=O)(=O)C(C)C)cc4OC)c3)cnnc21 CHEMBL3647566 Ki 11.7 nM
Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2 CHEMBL661 EC50 12.0 nM
Clc1ccc2c(c1)[nH]c1c2ncc2[nH]c3ccccc3c21 CHEMBL496990 Ki 12.0 nM
COc1ccc2c(c1)[nH]c1c2ncc2[nH]c3ccccc3c21 CHEMBL497197 Ki 12.0 nM
c1ccc2c(c1)[nH]c1cnc3c4cccnc4[nH]c3c12 CHEMBL2008708 Ki 12.0 nM
CCS(=O)(=O)c1ccc(-c2cc(-c3cnnc4c3ncn4C(C)C)ccc2F)c(OC)c1 CHEMBL3647581 Ki 14.0 nM
CCS(=O)(=O)c1ccc(-c2cc(-c3cnnc4c3ncn4C(C)C)ccc2F)c(Cl)c1 CHEMBL3647580 Ki 14.4 nM
CC(C)(C)OC(=O)c1cc2c(cn1)[nH]c1ccccc12 CHEMBL509197 Ki 15.0 nM
CCCC(=O)c1cc2c(cn1)[nH]c1ccccc12 CHEMBL510764 Ki 16.0 nM
CNS(=O)(=O)c1ccc(-c2cc(-c3cnnc4c3ncn4C(C)C)ccc2F)cc1 CHEMBL3647549 Ki 16.4 nM
CN1C(=O)CN=C(c2ccccc2)c2cc(Cl)ccc21 CHEMBL12 Ki 17.0 nM
CCOC(=O)c1ncn2c1[C@@H]1CCCN1C(=O)c1cc(OC)ccc1-2 CHEMBL52030 Ki 17.0 nM
CCn1cnc2c(-c3ccc(F)c(-c4ccc(S(C)(=O)=O)cc4)c3)cnnc21 CHEMBL3647562 Ki 17.7 nM
CCn1cnc2c(-c3ccc(F)c(-c4ccc(S(=O)(=O)CC)cc4F)c3)cnnc21 CHEMBL3647568 Ki 18.2 nM
CNS(=O)(=O)c1ccc(-c2cc(-c3cnnc4c3ncn4C3CC3)ccc2F)cc1 CHEMBL3647571 Ki 19.0 nM
CCOC(=O)c1nc(C)c2[nH]c3cc(OC)c(OC)cc3c2c1CC CHEMBL5275690 Ki 19.0 nM
COc1cc(S(=O)(=O)C(C)C)ccc1-c1cc(-c2cnnc3c2ncn3C(C)C)ccc1F CHEMBL3647578 Ki 19.1 nM
Oc1nc2c(c3nc(-c4ccccc4F)cn13)CN(Cc1ccccc1)CC2 CHEMBL356161 EC50 20.0 nM
CCn1cnc2c(-c3ccc(F)c(-c4ccc(S(=O)(=O)CC)cc4)c3)cnnc21 CHEMBL3647559 Ki 21.7 nM
CCS(=O)(=O)c1ccc(-c2cc(-c3cnnc4c3ncn4C(C)C)ccc2F)cc1 CHEMBL3647547 Ki 23.9 nM
Clc1ccc2c(c1)-c1ncnn1Cc1c(Cl)ncn1-2 CHEMBL1077391 Ki 24.0 nM
c1ccc2c(c1)[nH]c1cnc3c4ccncc4[nH]c3c12 CHEMBL5281056 Ki 24.0 nM
c1ccc(-c2nnc3c4c(c(OCc5ccccn5)nn23)C2CCC4CC2)cc1 CHEMBL178942 Ki 26.0 nM
COc1ccc(OC)c(-c2cccc3c(N)c(C(=O)NC4CCC4)nnc23)c1 CHEMBL1783257 pKi 26.3 nM
CCS(=O)(=O)c1ccc(-c2cc(-c3cnnc4c3ncn4C(C)C)ccc2F)c(C#N)c1 CHEMBL3647582 Ki 29.1 nM
CCNC(=O)c1nnc2c(-c3cc(OC)ccc3OC)cccc2c1N CHEMBL1783258 pKi 29.51 nM
CCn1cnc2c(-c3ccc(Cl)c(-c4ccc(S(=O)(=O)CC)cc4OC)c3)cnnc21 CHEMBL3647555 Ki 29.7 nM
COC(=O)c1cc2c(cn1)[nH]c1ccc(NCc3ccccc3)cc12 CHEMBL5290746 Ki 30.0 nM
CCn1cnc2c(-c3ccc(F)c(-c4ccc(S(=O)(=O)C(C)C)cc4)c3)cnnc21 CHEMBL3647533 Ki 31.1 nM
CCS(=O)(=O)c1ccc(-c2cc(-c3cnnc4c3ncn4C3CC3)ccc2F)cc1 CHEMBL3647541 Ki 31.1 nM
Cc1c(F)c(Nc2ccc(-c3cn(C)cn3)cn2)cc2c1ncn2CC1CC1 CHEMBL4581355 Ki 32.0 nM
CCS(=O)(=O)c1ccc(-c2cc(-c3cnnc4c3ncn4C(C)C)ccc2F)c(F)c1 CHEMBL3647550 Ki 34.5 nM
CCS(=O)(=O)c1ccc(-c2cc(-c3cnnc4c3ncn4C3(C)CC3)ccc2F)cc1 CHEMBL3647543 Ki 34.8 nM
CCn1cnc2c(-c3ccc(F)c(-c4ccc(S(=O)(=O)CC)cc4C(F)F)c3)cnnc21 CHEMBL3647567 Ki 35.4 nM
COc1cc(S(C)(=O)=O)ccc1-c1cc(-c2cnnc3c2ncn3C2CC2)ccc1F CHEMBL3647575 Ki 37.1 nM
CC(C)n1cnc2c(-c3ccc(F)c(-c4ccc(S(=O)(=O)C(C)C)cc4C#N)c3)cnnc21 CHEMBL3647551 Ki 38.8 nM
CCn1cnc2c(-c3ccc(F)c(-c4ccc(S(=O)(=O)CC)cc4C#N)c3)cnnc21 CHEMBL3647564 Ki 39.2 nM
COc1cc(S(=O)(=O)C(C)C)ccc1-c1cc(-c2cnnc3c2ncn3C2CC2)ccc1F CHEMBL3647574 Ki 40.5 nM
[C-]#[N+]c1ccc(-c2cnnc3c2ncn3CC)cc1-c1ccc(S(=O)(=O)CC)cc1OC CHEMBL3647557 Ki 40.6 nM
CS(=O)(=O)c1ccc(-c2cc(-c3cnnc4c3ncn4C3CC3)ccc2F)cc1 CHEMBL3647572 Ki 43.3 nM
CCCOc1cc2c(cn1)[nH]c1ccccc12 CHEMBL499814 Ki 52.0 nM
O=C(c1ccc(F)cc1)N1CCc2nc(O)n3cc(-c4ccccc4F)nc3c2C1 CHEMBL147842 EC50 55.0 nM
CCn1cnc2c(-c3cccc(-c4ccc(S(C)(=O)=O)cc4)c3)cnnc21 CHEMBL3647569 Ki 56.0 nM
COc1ccc(OC)c(-c2cccc3c(N)c(C(=O)NC(C)C)nnc23)c1 CHEMBL1783259 pKi 56.23 nM
Fc1ccc(COc2c3cnc4c(c3nn2-c2ccc(Cl)cc2)CCCC4)cc1 CHEMBL1681897 IC50 57.0 nM
CCn1cnc2c(-c3ccc(F)c(-c4ccc(S(=O)(=O)C(C)C)cc4F)c3)cnnc21 CHEMBL3647563 Ki 61.3 nM
Oc1nc2c(c3nc(-c4ccccc4F)cn13)CN(Cc1cccs1)CC2 CHEMBL147364 EC50 67.0 nM
CCS(=O)(=O)c1ccc(-c2cc(-c3cnnc4c3ncn4C3CC3)ccc2F)c(F)c1 CHEMBL3647573 Ki 67.8 nM
CCn1cnc2c(-c3ccc(F)c(-c4ccc5c(c4)CC(C)S5(=O)=O)c3)cnnc21 CHEMBL3647560 Ki 69.5 nM
O=C(c1cccc(F)c1)N1CCc2nc(O)n3cc(-c4ccccc4F)nc3c2C1 CHEMBL356806 EC50 70.0 nM
CCS(=O)(=O)c1ccc(-c2cc(-c3cnnc4c3ncn4C3CCC3)ccc2F)cc1 CHEMBL3647544 Ki 74.3 nM
Oc1nc2c(c3nc(-c4ccccc4F)cn13)CN(c1ncccn1)CC2 CHEMBL146488 EC50 84.0 nM
CC(C)n1cnc2c(-c3ccc(F)c(-c4ccc(S(=O)(=O)C(C)C)cc4F)c3)cnnc21 CHEMBL3647577 Ki 87.4 nM
COc1cc(S(N)(=O)=O)ccc1-c1cc(-c2cnnc3c2ncn3C2CCCC2)ccc1F CHEMBL3647552 Ki 91.4 nM
CCn1cnc2c(-c3ccc(O)c(-c4ccc(S(=O)(=O)CC)cc4OC)c3)cnnc21 CHEMBL3647558 Ki 92.2 nM
Oc1nc2c(c3nc(-c4ccccc4F)cn13)CN(Cc1ccncc1)CC2 CHEMBL342270 EC50 99.0 nM
Oc1nc2c(c3nc(-c4ccccc4F)cn13)CN(Cc1cccnc1)CC2 CHEMBL146086 EC50 101.0 nM
COc1cc(S(C)(=O)=O)ccc1-c1cc(-c2cnnc3c2ncn3C2CCC2)ccc1F CHEMBL3647545 Ki 101.0 nM
CCn1cnc2c(-c3cccc(-c4ccc5c(c4)CCS5(=O)=O)c3)cnnc21 CHEMBL3647570 Ki 102.0 nM
CCn1cnc2c(-c3ccc(F)c(-c4ccc(S(=O)(=O)C(C)C)cc4C#N)c3)cnnc21 CHEMBL3647537 Ki 108.0 nM
CCC(=O)N1CCc2nc(O)n3cc(-c4ccccc4F)nc3c2C1 CHEMBL358519 EC50 110.0 nM
C#Cc1ccc2[nH]c3cnc(C(=O)OC(C)(C)C)cc3c2c1 CHEMBL1270038 Ki 110.0 nM
CCS(=O)(=O)c1ccc(-c2cc(-c3cnnc4c3ncn4C3CCCC3)ccc2F)c(OC)c1 CHEMBL3647553 Ki 118.0 nM
C#Cc1ccc2c(c1)C(c1ccccn1)=NCc1c(-c3cnco3)ncn1-2 CHEMBL4062225 Ki 118.0 nM
CCCn1cnc2c(-c3ccc(F)c(-c4ccc(S(=O)(=O)CC)cc4)c3)cnnc21 CHEMBL3647546 Ki 120.0 nM
Cc1ccccc1C(=O)N1CCc2nc(O)n3cc(-c4ccccc4F)nc3c2C1 CHEMBL344120 EC50 134.0 nM
COc1ccc(-c2cn3c(O)nc4c(c3n2)CN(Cc2ccccc2)CC4)cc1 CHEMBL356271 EC50 143.0 nM
CCS(=O)(=O)c1ccc(-c2cc(-c3cnnc4c3ncn4C3CCC3)ccc2F)c(F)c1 CHEMBL3647542 Ki 147.0 nM
Oc1nc2c(c3nc(-c4cccc(F)c4)cn13)CN(Cc1ccccc1)CC2 CHEMBL145983 EC50 154.0 nM
Fc1ccccc1COc1c2cnc3c(c2nn1-c1ccc(Cl)cc1)CCCC3 CHEMBL1681895 IC50 154.0 nM
Clc1ccccc1COc1c2cnc3ccccc3c2nn1-c1ccc2c(c1)OCO2 CHEMBL1681888 IC50 155.0 nM
CCS(=O)(=O)c1ccc(-c2cc(-c3cnnc4c3ncn4C3CC3)ccc2F)c(C#N)c1 CHEMBL3647576 Ki 170.0 nM
Clc1ccc(COc2c3cnc4c(c3nn2-c2ccc(Cl)cc2)CCCC4)cc1 CHEMBL1681894 IC50 177.0 nM
COCc1ncn2c1CN(C)C(=O)c1cc(Cl)ccc1-2 CHEMBL45346 Ki 180.0 nM
Oc1nc2c(c3nc(-c4ccccc4)cn13)CN(Cc1ccccc1)CC2 CHEMBL148740 EC50 184.0 nM
Clc1ccc(-n2nc3c4c(ncc3c2OCC2CC2)CCCC4)cc1 CHEMBL1681900 IC50 185.0 nM
FC(F)c1ncn2c1Cn1ncnc1-c1cc(Br)ccc1-2 CHEMBL1080588 Ki 185.0 nM
Oc1nc2c(c3nc(-c4cc(F)ccc4F)cn13)CN(Cc1ccccc1)CC2 CHEMBL145910 EC50 188.0 nM
Oc1nc2c(c3nc(-c4ccccc4F)cn13)CN(CC1CCCCC1)CC2 CHEMBL146230 EC50 202.0 nM
Oc1nc2c(c3nc(-c4ccc(F)cc4F)cn13)CN(Cc1ccccc1)CC2 CHEMBL343009 EC50 210.0 nM
CC1(C)CCc2ncc3c(OCc4ccccc4Cl)n(-c4ccc(Cl)cc4)nc3c2C1 CHEMBL1681892 IC50 213.0 nM
O=C(c1ccc(F)c(F)c1)N1CCc2nc(O)n3cc(-c4ccccc4F)nc3c2C1 CHEMBL147590 EC50 238.0 nM
Oc1nc2c(c3nc(-c4ccc(F)cc4)cn13)CN(Cc1ccccc1)CC2 CHEMBL148044 EC50 245.0 nM
CCCCN1CCc2nc(O)n3cc(-c4ccccc4F)nc3c2C1 CHEMBL147379 EC50 247.0 nM
O=C(c1ccccc1F)N1CCc2nc(O)n3cc(-c4ccccc4F)nc3c2C1 CHEMBL146302 EC50 256.0 nM
Clc1ccc(-n2nc3c(cnc4ccccc43)c2OCc2ccccc2Cl)cc1 CHEMBL1681886 IC50 265.0 nM
COc1cccc(-c2cn3c(O)nc4c(c3n2)CN(Cc2ccccc2)CC4)c1 CHEMBL146356 EC50 268.0 nM
Clc1ccc(-n2nc3c4c(ncc3c2OCc2ccccc2Cl)CCCC4)cc1 CHEMBL1681889 IC50 271.0 nM
C=CCN1CCc2nc(O)n3cc(-c4ccccc4F)nc3c2C1 CHEMBL358301 EC50 284.0 nM
CC(C)S(=O)(=O)c1ccc(-c2cc(-c3cnnc4c3ncn4C3CC3)ccc2F)c(C#N)c1 CHEMBL3647540 Ki 296.0 nM
Cc1ccc(C(=O)N2CCc3nc(O)n4cc(-c5ccccc5F)nc4c3C2)cc1 CHEMBL343471 EC50 327.0 nM
C#Cc1ccc2c(c1)C(c1ccccc1F)=N[C@H](C)c1c(C(=O)NC)ncn1-2 CHEMBL4228824 Ki 360.0 nM
COc1ccc(C(=O)N2CCc3nc(O)n4cc(-c5ccccc5F)nc4c3C2)cc1 CHEMBL146317 EC50 383.0 nM
Oc1nc2c(c3nc(-c4ccccc4F)cn13)CN(Cc1c[nH]cn1)CC2 CHEMBL358874 EC50 459.0 nM
Clc1ccc(-n2nc3c4c(ncc3c2OCc2ccccc2Cl)CCOC4)cc1 CHEMBL1681891 IC50 461.0 nM
Clc1ccc(-n2nc3c(cnc4ccccc43)c2OCC2CC2)cc1 CHEMBL1681885 IC50 472.0 nM
Cc1onc(-c2ccc(F)cc2)c1COc1ccc(C(=O)N2CCS(=O)(=O)CC2)cn1 CHEMBL3681419 Ki 502.0 nM
Clc1ccc(-n2nc3c4c(ncc3c2OCc2ccccc2Cl)CCCCC4)cc1 CHEMBL1681890 IC50 605.0 nM
CCn1cnc2c(-c3ccc(CO)c(-c4ccc(S(=O)(=O)CC)cc4F)c3)cnnc21 CHEMBL3647554 Ki 678.0 nM
Cc1ccc(-c2nc3ccc(C)cn3c2CC(=O)N(C)C)cc1 CHEMBL911 EC50 737.0 nM
C#Cc1ccc2c(c1)C(c1ccccc1F)=N[C@H](C)c1c(C(=O)NC3CC3)ncn1-2 CHEMBL4553352 Ki 789.0 nM
Oc1nc2c(c3nc(-c4ccccc4-c4cccs4)cn13)CN(Cc1ccccc1)CC2 CHEMBL148043 EC50 879.0 nM
C#Cc1ccc2c(c1)C(c1ccccn1)=NCc1c(C(=O)OC)ncn1-2 CHEMBL4537371 Ki 1000.0 nM
CC(OC(=O)c1cc2c(cn1)[nH]c1ccccc12)c1ccccc1 CHEMBL1270841 Ki 1000.0 nM