Clc1cc2cc(c1)-c1cnn3ccc(nc13)NCCOCCO2 CHEMBL4531690 IC50 0.06 nM
COc1cccc(Nc2ncnn3ccc(CN4CC[C@@H](N)[C@H](O)C4)c23)c1 CHEMBL3545396 Kd apparent 0.3 nM
COc1cc2ncc(C#N)c(Nc3cc(OC)c(OC)c(OC)c3)c2cc1OC CHEMBL81073 Kd 0.42 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 IC50 1.0 nM
CCOc1cc(N2CCN(C)CC2)ccc1Nc1ncc2cc(-c3cccc(NC(=O)c4cccc(C(F)(F)F)c4)c3)c(=O)n(C[C@H]3CCCO3)c2n1 CHEMBL5415503 Kd 1.0 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 Kd 1.3 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL607707 Kd 1.5 nM
COc1cc(-c2cnc3cc(-c4ccncc4)ccc3c2)cc(OC)c1OC CHEMBL4797973 Ki 1.5 nM
COc1cc(Nc2ccnc3ccc(Br)cc23)cc(OC)c1OC CHEMBL4443342 Kd 1.9 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12 CHEMBL400402 Kd apparent 2.0 nM
COc1cc(-c2cnc3c(-c4cccc(NC(=O)N5CCCC5)c4)snc3c2)ccc1N CHEMBL4740761 IC50 2.2 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL5416410 Kd 2.6 nM
C#Cc1cccc(Nc2c(C#N)cnc3cc(OC)c(OC)cc23)c1 CHEMBL4440586 Kd 2.6 nM
COc1cc2nccc(Nc3cc(OC)c(OC)c(OC)c3)c2cc1OC CHEMBL311959 Kd 2.9 nM
CNC(=O)c1nn(C)c2c1C(C)(C)Cc1cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc1-2 CHEMBL564829 Kd apparent 3.0 nM
C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1 CHEMBL553 Kd 3.1 nM
COc1cc(-c2cnc3c(-c4cccc(NC(=O)N5CCOCC5)c4)snc3c2)ccc1N CHEMBL4778276 IC50 3.2 nM
COc1cc(-c2cnc3c(-c4cccc(NC(=O)C(C)C)c4)snc3c2)ccc1N CHEMBL4762694 IC50 3.8 nM
COc1cc(Nc2ccnc3ccc(C#N)cc23)cc(OC)c1OC CHEMBL4585158 Kd 3.9 nM
COCCN1CCN(Cc2ccc(-c3n[nH]c4c3C(=O)c3c(NC(=O)NN5CCOCC5)cccc3-4)cc2)CC1 CHEMBL3545083 Kd apparent 4.0 nM
COc1cccc(Nc2ccnc3ccc(C(F)(F)F)cc23)c1 CHEMBL4781252 Kd 4.9 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 5.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 5.3 nM
COc1cc(Nc2ccnc3ccc(Cl)cc23)cc(OC)c1OC CHEMBL4556662 Kd 6.3 nM
C#Cc1cccc(Nc2ncnc3cc(OC)c(OC)cc23)c1 CHEMBL304929 Kd 6.8 nM
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 CHEMBL939 Kd 7.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 7.3 nM
C#Cc1cccc(Nc2ccnc3cc(OC)c(OC)cc23)c1 CHEMBL1092250 Kd 7.6 nM
COc1cc(Nc2ccnc3cc(I)ccc23)cc(OC)c1OC CHEMBL4740155 Kd 7.6 nM
CCC(=O)Nc1cccc(-c2snc3cc(-c4ccc(N)c(OC)c4)cnc23)c1 CHEMBL4764705 IC50 7.7 nM
COc1cc(Nc2ccnc3ccc(I)cc23)cc(OC)c1OC CHEMBL4517424 Kd 7.9 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 8.2 nM
COc1cc(-c2cnc3c(N4CCOCC4)snc3c2)cc(OC)c1OC CHEMBL3425865 Kd 8.3 nM
COc1cc(Nc2ccnc3cc(Br)ccc23)cc(OC)c1OC CHEMBL4782290 Kd 8.6 nM
COc1cc(-c2cnc3c(-c4cccc(NC(=O)C5CC5)c4)snc3c2)ccc1N CHEMBL4794323 IC50 8.8 nM
COc1cc(-c2cnc3c(N4CCOCC4)snc3c2)ccc1N CHEMBL3425867 Kd 8.9 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1 CHEMBL3301622 Kd apparent 9.0 nM
COc1cc(Nc2ccnc3cc(C#N)ccc23)cc(OC)c1OC CHEMBL4575895 Kd 9.7 nM
COc1cc2ncnc(Nc3cc(OC)c(OC)c(OC)c3)c2cc1OC CHEMBL309682 Kd 10.0 nM
COc1cc(Nc2ccnc3ccc(C(F)(F)F)cc23)cc(OC)c1OC CHEMBL535429 Kd 10.0 nM
COc1cc(-c2cnc3c(N4C[C@@H](C)O[C@H](C)C4)snc3c2)ccc1N CHEMBL4165336 Kd 11.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 11.0 nM
COc1cc2ncc(C#N)c(Nc3cccc(Br)c3)c2cc1OC CHEMBL111038 Kd 12.0 nM
C=CC(=O)Nc1cccc(-c2snc3cc(-c4ccc(N)c(OC)c4)cnc23)c1 CHEMBL4745919 IC50 12.0 nM
COc1cc(Nc2ccnc3cc(Cl)ccc23)cc(OC)c1OC CHEMBL3925728 Kd 13.0 nM
COc1cc(-c2cnc3c(N4CCC[C@H](CNC(=O)C5CC5)C4)snc3c2)ccc1N CHEMBL4745028 IC50 13.0 nM
COc1cc(-c2cnc3c(N4CCCC(CNC(=O)C5CC5)C4)snc3c2)ccc1N CHEMBL4800032 IC50 14.0 nM
COc1ccc2c(Nc3cc(OC)c(OC)c(OC)c3)ccnc2c1 CHEMBL4586530 Kd 17.0 nM
COc1cc(-c2cnc3c(-c4cccc(NC(=O)C5CCCC5)c4)snc3c2)ccc1N CHEMBL4779229 IC50 17.0 nM
COc1cc(-c2cnc3c(N4CCOCC4)snc3c2)ccc1OC(C)=O CHEMBL3425866 Kd 18.0 nM
COc1cc(-c2cnc3c(N4CCOCC4)snc3c2)ccc1O CHEMBL3425868 Kd 18.0 nM
COc1cc(-c2cnc3c(N4CCOC[C@@H]4C)snc3c2)ccc1N CHEMBL4169166 Kd 18.0 nM
C[S+]([O-])c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL10 Kd 19.0 nM
COc1cc(-c2cnc3c(N4CCO[C@H](C)C4)snc3c2)ccc1N CHEMBL4163357 Kd 19.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 20.0 nM
COc1ccc2nccc(Nc3cc(OC)c(OC)c(OC)c3)c2c1 CHEMBL4592501 Kd 21.0 nM
COc1cc(-c2cnc3c(N4C[C@@H](C)O[C@@H](C)C4)snc3c2)ccc1C(N)=O CHEMBL4646895 IC50 22.0 nM
Cn1cc(C2=Nc3cc(NC(=O)C(N)C4CCCCC4)cc4c3C2=CNNC4=O)cn1 CHEMBL3545137 Kd apparent 23.0 nM
COc1cc(Nc2ccnc3cc(C(F)(F)F)ccc23)cc(OC)c1OC CHEMBL4746133 Kd 23.0 nM
COc1ccc(-c2ccc3nsc(N4C[C@@H](C)O[C@@H](C)C4)c3n2)cc1OC CHEMBL4642467 IC50 24.0 nM
COc1cc(Nc2ccnc3ccc(C(C)(C)C)cc23)cc(OC)c1OC CHEMBL530635 Kd 25.0 nM
COc1cc(-c2cnc3c(N4CCO[C@@H](C)C4)snc3c2)ccc1N CHEMBL4174075 Kd 26.0 nM
COc1ccc(-c2cnc3c(NCC4CC4)snc3c2)cc1OC CHEMBL3425873 Kd 27.0 nM
COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC CHEMBL29197 Kd 29.0 nM
COc1cc(-c2cnc3c(N4CCOC(C)(C)C4)snc3c2)ccc1N CHEMBL4177020 Kd 35.0 nM
COc1cc(-c2cnc3c(N4CCCC(CNC(=O)c5ccccc5)C4)snc3c2)ccc1N CHEMBL4752286 IC50 35.0 nM
COc1cc(-c2cnc3c(N4CCCC(CNC(=O)N5CCCC5)C4)snc3c2)ccc1N CHEMBL4784439 IC50 37.0 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 Kd 38.0 nM
COc1cc(-c2cnc3c(N4CCCC(CNC(=O)C5CCCC5)C4)snc3c2)ccc1N CHEMBL4755134 IC50 39.0 nM
COc1cc(-c2cnc3c(N4C[C@@H](C)O[C@@H](C)C4)snc3c2)ccc1N CHEMBL4172550 IC50 39.4 nM
COc1ccc(-c2cnc3c(-c4ccc(OC)c(OC)c4)snc3c2)cc1OC CHEMBL4558505 Kd 41.0 nM
c1cc(-c2cnc3c(N4CCOCC4)snc3c2)cs1 CHEMBL3425847 Kd 42.0 nM
COc1cc(-c2cnc3c(N4C[C@@H](C)O[C@@H](C)C4)snc3c2)ccc1C(=O)O CHEMBL4645917 IC50 42.0 nM
C=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1 CHEMBL31965 Kd 44.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 44.0 nM
COc1cc(-c2cnc3c(N4CCOC(C)C4)snc3c2)ccc1N CHEMBL4159994 Kd 46.0 nM
c1csc(-c2cnc3c(N4CCOCC4)snc3c2)c1 CHEMBL3425859 Kd 47.0 nM
Cc1[nH]nc(Nc2ncnc3cc(OCCO)c(S(=O)(=O)C(C)(C)C)cc23)c1C CHEMBL4535001 Ki 49.0 nM
O=C(Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1)C1CCCN1 CHEMBL3545328 Kd apparent 50.0 nM
COc1ccc(-c2cnc3c(N4CCOCC4)snc3c2)cc1OC CHEMBL3425846 Kd 52.0 nM
COc1cc(-c2cnc3c(N4CCNC(=O)C4)snc3c2)ccc1N CHEMBL4171678 Kd 52.0 nM
Oc1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL278041 Kd 53.0 nM
COc1cc(Nc2ccnc3ccc(F)cc23)cc(OC)c1OC CHEMBL4744568 Kd 58.0 nM
COc1cc(Nc2ccnc3ccccc23)cc(OC)c1OC CHEMBL4586588 Kd 59.0 nM
COc1cc(-c2cnc3c(N4CC5CCC(C4)O5)snc3c2)ccc1N CHEMBL4170643 Kd 61.0 nM
COc1cc(-c2cnc3c(N4CCCC(CNC(=O)NC5CC5)C4)snc3c2)ccc1N CHEMBL4790097 IC50 62.0 nM
COc1ccc(-c2cnc3c(N4CCC(O)CC4)snc3c2)cc1OC CHEMBL3425877 Kd 63.0 nM
COc1cc(-c2cnc3c(N4CCCC(CNC(=O)CC(C)C)C4)snc3c2)ccc1N CHEMBL4760106 IC50 69.0 nM
COc1cc(-c2cnc3c(N4C[C@@H](C)O[C@@H](C)C4)snc3c2)cc(OC)c1OC CHEMBL4642620 IC50 71.0 nM
COc1cc(OC)cc(-c2cnc3c(N4CCOCC4)snc3c2)c1 CHEMBL3425863 Kd 72.0 nM
COc1cc(-c2cnc3c(N4C[C@@H](C)O[C@@H](C)C4)snc3c2)ccc1C(=O)NCc1ccccc1 CHEMBL4636314 IC50 73.0 nM
CC(C)C[C@](C)(N)COc1ccc(-c2ccnc(C(F)F)c2)cc1C(F)F CHEMBL5088205 IC50 73.0 nM
CCC(C)Oc1snc2cc(-c3ccc(OC)c(OC)c3)cnc12 CHEMBL3754235 Kd 74.0 nM
CCC(=O)NCC1CCCN(c2snc3cc(-c4ccc(N)c(OC)c4)cnc23)C1 CHEMBL4782363 IC50 74.0 nM
COc1cc(Nc2ccnc3cc(F)ccc23)cc(OC)c1OC CHEMBL4752943 Kd 76.0 nM
COc1cc(-c2cnc3c(N4CCCC(CNS(=O)(=O)C5CC5)C4)snc3c2)ccc1N CHEMBL4753946 IC50 78.0 nM
C=CC(=O)NCC1CCCN(c2snc3cc(-c4ccc(N)c(OC)c4)cnc23)C1 CHEMBL4756485 IC50 78.0 nM
CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 CHEMBL1173655 Kd 79.0 nM
CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 CHEMBL2105712 Kd 79.0 nM
COc1cc(-c2cnc3c(NC4CCOCC4)snc3c2)ccc1N CHEMBL4163801 Kd 80.0 nM
COc1cc(-c2cnc3c(N4C[C@@H](C)O[C@@H](C)C4)snc3c2)ccc1C(=O)N1CCCC1 CHEMBL4643096 IC50 83.0 nM
COc1ccc(-c2cnc3c(OC(C)C)snc3c2)cc1OC CHEMBL3753017 Kd 85.0 nM
COc1cc(-c2cnc3c(N4CCCC(CNC(=O)N5CCOCC5)C4)snc3c2)ccc1N CHEMBL4799769 IC50 85.0 nM
COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 CHEMBL24828 Kd 86.0 nM
COc1ccc(-c2cnc3c(NC4CCOCC4)snc3c2)cc1OC CHEMBL3425878 Kd 88.0 nM
N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL1789941 Kd 99.0 nM
COc1cccc(-c2ccc3nsc(N4C[C@@H](C)O[C@@H](C)C4)c3n2)c1 CHEMBL4641825 IC50 99.0 nM
COc1ccc(-c2cnc3c(N4CCCC4)snc3c2)cc1OC CHEMBL3425872 Kd 100.0 nM
COc1cc(-c2cnc3c(N4C[C@@H](C)O[C@@H](C)C4)snc3c2)ccc1C(=O)N1CCOCC1 CHEMBL4632903 IC50 101.0 nM
CN1CCN(CCOc2cc(OC3CCOCC3)c3c(Nc4c(Cl)ccc5c4OCO5)ncnc3c2)CC1 CHEMBL217092 Kd apparent 108.0 nM
COc1ccc(-c2cnc3c(N4C[C@@H](C)O[C@@H](C)C4)snc3c2)cc1OC CHEMBL3425876 Kd 110.0 nM
CC(C)Oc1snc2cc(-c3ccsc3)cnc12 CHEMBL3753050 Kd 110.0 nM
C[C@@H]1CN(c2snc3ccc(-c4ccc(F)cc4)nc23)C[C@H](C)O1 CHEMBL4639991 IC50 110.0 nM
COc1cc(-c2cnc3c(N4C[C@@H](C)O[C@@H](C)C4)snc3c2)ccc1NC=O CHEMBL4638602 IC50 113.0 nM
COc1cc(-c2cnc3c(N4C[C@@H](C)O[C@@H](C)C4)snc3c2)ccc1C(=O)NC1CC1 CHEMBL4632372 IC50 118.0 nM
COc1ccc(-c2cnc3c(NCCO)snc3c2)cc1OC CHEMBL3425841 Kd 120.0 nM
COc1cc2ncnc3c2cc1OCCCCCN(C)Cc1ccc(Br)cc1N3 CHEMBL3109738 Kd apparent 120.0 nM
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3ncnc4[nH]ccc34)cn2)C1 CHEMBL2105759 Kd 120.0 nM
COc1ccc(-c2ccc3nsc(N4CCOCC4)c3n2)cc1OC CHEMBL4633404 IC50 124.0 nM
COc1cc(OC)cc(-c2ccc3nsc(N4CCOCC4)c3n2)c1 CHEMBL4642058 IC50 126.0 nM
COc1ccc(OC)c(-c2cnc3c(N4CCOCC4)snc3c2)c1 CHEMBL3425862 Kd 130.0 nM
COc1cc(Nc2ncnc3ccc(C(F)(F)F)cc23)cc(OC)c1OC CHEMBL4446630 Kd 130.0 nM
COc1cc(-c2cnc3c(N4C[C@@H](C)O[C@@H](C)C4)snc3c2)ccc1NC(C)=O CHEMBL4640730 IC50 132.0 nM
COc1cccc(-c2ccc3nsc(N4CCOCC4)c3n2)c1 CHEMBL4635935 IC50 136.0 nM
COCCNc1snc2cc(-c3ccc(OC)c(OC)c3)cnc12 CHEMBL3425870 Kd 140.0 nM
CCOc1cc(N2CCC(O)CC2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CCC(=O)N2C CHEMBL3974629 IC50 140.0 nM
COc1ccc(-c2cnc3c(c2)ncn3-c2ccccc2)cc1OC CHEMBL5219769 Kd 140.0 nM
COCCOc1cc2ncnc(Nc3cc(OC)c(OC)c(OC)c3)c2cc1OCCOC CHEMBL4468521 Kd 150.0 nM
O[C@H]1CC[C@H](Nc2ncc3nc(Nc4c(F)cc(F)cc4F)n([C@H]4CCOC4)c3n2)CC1 CHEMBL1950289 Kd apparent 156.0 nM
COc1cc(-c2cnc3c(N4CCCC(C(N)=O)C4)snc3c2)ccc1N CHEMBL4160425 Kd 160.0 nM
COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C(F)F)n2)ccn1 CHEMBL5202142 IC50 160.0 nM
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN1CCCCC1 CHEMBL2110732 Kd apparent 168.0 nM
COc1cc(-c2cnc3c(N4CC5(COC5)C4)snc3c2)ccc1N CHEMBL4175117 Kd 170.0 nM
COc1cc(-c2cnc3c(N4C[C@@H](C)O[C@@H](C)C4)snc3c2)ccc1NC(=O)C1CC1 CHEMBL4640641 IC50 173.0 nM
CNC(=O)CN1CCC(Oc2cc3c(Nc4cccc(Cl)c4F)ncnc3cc2OC)CC1 CHEMBL2408045 Kd apparent 176.0 nM
CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc2N1C1CCCC1 CHEMBL513909 Kd 180.0 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccccc4)c3)cc12 CHEMBL379218 Kd 180.0 nM
CCC(F)(F)c1cc(N2CCC(S(C)(=O)=O)CC2)nc2sc(C(N)=O)c(N)c12 CHEMBL4522930 IC50 188.0 nM
COc1ccc(-c2cnc3c(N(C)C)snc3c2)cc1OC CHEMBL3425869 Kd 190.0 nM
COc1cc(-c2cnc3c(N4CCCOCC4)snc3c2)ccc1N CHEMBL4167255 Kd 190.0 nM
CCC(=O)NCCC1CCCN(c2snc3cc(-c4ccc(N)c(OC)c4)cnc23)C1 CHEMBL4777592 IC50 190.0 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 Kd apparent 196.0 nM
Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O CHEMBL477772 Kd 200.0 nM
c1cc(-c2cnc3c(N4CCOCC4)snc3c2)co1 CHEMBL3425860 Kd 200.0 nM
NC(=O)Nc1cc(-c2cccc(F)c2)sc1C(=O)N[C@H]1CCCNC1 CHEMBL2041933 Kd apparent 202.0 nM
COc1cc(-c2cnc3c(N4CCS(=O)(=O)CC4)snc3c2)ccc1N CHEMBL4168337 Kd 210.0 nM
COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C)n2)ccn1 CHEMBL5170576 IC50 210.0 nM
Cc1ccc(-c2ccc3nsc(N4C[C@@H](C)O[C@@H](C)C4)c3n2)cc1 CHEMBL4648802 IC50 214.0 nM
CCOc1snc2cc(-c3ccsc3)cnc12 CHEMBL3754728 Kd 220.0 nM
CC(C)(C)S(=O)(=O)c1ccc2nccc(Nc3n[nH]c4ccc(F)cc34)c2c1 CHEMBL3823499 Ki 220.0 nM
COc1ccc(-c2cnc3c(N4CCSCC4)snc3c2)cc1OC CHEMBL3425875 Kd 230.0 nM
COc1cc2nccc(Nc3cccc(Br)c3)c2cc1OC CHEMBL98248 Kd 240.0 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL180022 Kd 250.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 250.0 nM
COc1cc(-c2cnc3c(N4CCC(C#N)CC4)snc3c2)ccc1N CHEMBL4159403 Kd 250.0 nM
CCc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL1738797 Kd apparent 259.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 260.0 nM
C[C@@H]1CN(c2snc3ccc(-c4cccc(Cl)c4)nc23)C[C@H](C)O1 CHEMBL4638387 IC50 262.0 nM
CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3c(cc2OC)CCN3C(=O)CN(C)C)nc2[nH]ccc12 CHEMBL464552 Kd 270.0 nM
COc1ccc(-c2cnc3c(N4CCCCC4)snc3c2)cc1OC CHEMBL3425874 Kd 270.0 nM
COc1ccc(-c2cnc3c(N4CCN(C(C)=O)CC4)snc3c2)cc1OC CHEMBL3754300 Kd 290.0 nM
OCCNc1snc2cc(-c3ccsc3)cnc12 CHEMBL3425842 Kd 300.0 nM
CCCCOc1snc2cc(-c3ccc(OC)c(OC)c3)cnc12 CHEMBL3753916 Kd 310.0 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 320.0 nM
COc1ccc(-c2cnc3c(N(CCO)CCO)snc3c2)cc1OC CHEMBL3425871 Kd 320.0 nM
COc1ccc(-c2cnc3c(OC4CCCCC4)snc3c2)cc1OC CHEMBL3753095 Kd 340.0 nM
CCN(C)S(=O)(=O)NCc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 CHEMBL4470026 Ki 360.0 nM
COc1cc(-c2cnc3c(N4CCC[C@@H](CNC(=O)C5CC5)C4)snc3c2)ccc1N CHEMBL4747444 IC50 360.0 nM
COc1ccc(-c2cnc3c(N4CCOCC4)snc3n2)cc1OC CHEMBL5221079 Kd 360.0 nM
C[C@@H]1CN(c2snc3ccc(-c4ccccc4)nc23)C[C@H](C)O1 CHEMBL4648554 IC50 364.0 nM
NC(=O)c1ccc(Nc2cc(-c3ccc(F)cc3)[nH]n2)cc1 CHEMBL511337 Kd 367.0 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1 CHEMBL428690 Kd 370.0 nM
COc1cc(-c2cnc3c(N4C[C@@H](C)O[C@@H](C)C4)snc3c2)ccc1NC(=O)c1ccccc1 CHEMBL4635431 IC50 370.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 380.0 nM
COc1ccc(-c2cnc3c(-c4cccc(C)c4)snc3c2)cc1OC CHEMBL4529993 Kd 400.0 nM
CC(C)C[C@](C)(N)COc1cnc(-c2ccnc(C(F)F)c2)cc1C(F)F CHEMBL5199698 IC50 400.0 nM
C=CCn1c(=O)c2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2n1-c1cccc(C(C)(C)O)n1 CHEMBL1976040 Kd apparent 418.0 nM
COc1cc(-c2ccc3nsc(N4C[C@@H](C)O[C@@H](C)C4)c3n2)cc(OC)c1OC CHEMBL4637058 IC50 422.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL1240703 Kd 430.0 nM
C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(OCCN(C)C)cc4OC)nc32)c1 CHEMBL3633152 Kd 430.0 nM
COc1cc2c(-c3cnc(-c4ccc[nH]4)o3)c[nH]c2cc1Br CHEMBL4564337 Kd 440.0 nM
COC(=O)Nc1cc(-c2cnc(OC[C@@](C)(N)CC(C)C)c(C)c2)ccn1 CHEMBL5184381 IC50 440.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C CHEMBL1673039 Kd 450.0 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3OC)ncc2C(F)(F)F)c1 CHEMBL3545308 Kd apparent 450.0 nM
COc1cc(Nc2ccnc3ccc(S(C)(=O)=O)cc23)cc(OC)c1OC CHEMBL4746235 Kd 450.0 nM
COc1cc(Nc2cnc3c(N4C[C@@H](C)O[C@@H](C)C4)snc3c2)cc(OC)c1OC CHEMBL4634338 IC50 458.0 nM
C#Cc1cccc(Nc2ncnc3cc(OC)c(OCCCCCCC(=O)NO)cc23)c1 CHEMBL598797 Kd apparent 482.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 Kd 490.0 nM
Cc1cccc(-c2nn3c(c2-c2ccnc4ccc(C(N)=O)cc24)CCC3)n1 CHEMBL2364611 Kd apparent 495.0 nM
c1ccc(-c2cnc3c(N4CCOCC4)snc3c2)cc1 CHEMBL3425844 Kd 500.0 nM
C=CC(=O)Nc1ccc(-c2snc3cc(-c4ccc(N)c(OC)c4)cnc23)cc1 CHEMBL4800155 IC50 500.0 nM
O=C(Nc1n[nH]c2cc(-c3cccc(CNS(=O)(=O)CCC(F)(F)F)c3)ccc12)C1CC1 CHEMBL4447403 Ki 510.0 nM
COc1ccc(-c2cnc3c(-c4ccncc4)snc3c2)cc1OC CHEMBL4574041 Kd 520.0 nM
COc1cc(-c2cnc3c(N4C[C@@H](C)O[C@@H](C)C4)snc3c2)ccn1 CHEMBL4636735 IC50 545.0 nM
CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL3991929 Kd apparent 552.0 nM
O=C(Nc1n[nH]c2cc(-c3cccc(CNS(=O)(=O)CC(F)(F)F)c3)ccc12)C1CC1 CHEMBL4582326 Ki 580.0 nM
C[C@@H]1COCCN1c1cc(-c2ccnn2C)c2ccnc(-c3ccn[nH]3)c2n1 CHEMBL4647810 Kd 580.0 nM
Nc1c(C(=O)c2cccc(OC[C@@H](O)CO)c2)cnn1-c1ccc(F)cc1 CHEMBL203567 Kd 590.0 nM
COc1ccc(-c2cnc3c(OCCC(C)C)snc3c2)cc1OC CHEMBL3752816 Kd 590.0 nM
COc1ccc(-c2cnc3c(NC(=O)c4ccccc4)snc3c2)cc1OC CHEMBL3752472 Kd 600.0 nM
CCOC(=O)N1CCN(c2snc3cc(-c4ccc(OC)c(OC)c4)cnc23)CC1 CHEMBL3751921 Kd 610.0 nM
COc1cc2c(Nc3ccc(Cl)c(Cl)c3F)ncnc2cc1OC[C@@H]1C[C@@H]2CN(C)C[C@@H]2C1 CHEMBL3544983 Kd apparent 615.0 nM
COc1ccc(-c2ccc3c(N4CCOCC4)ncnc3c2)cc1OC CHEMBL5218560 Kd 620.0 nM
COc1ccc(-c2cnc3c(NC4CCNCC4)snc3c2)cc1OC CHEMBL3753792 Kd 640.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n1C1CCCC1 CHEMBL3545110 Kd apparent 658.0 nM
COc1ccc(-c2cnc3c(N4CCC(C)CC4)snc3c2)cc1OC CHEMBL3753335 Kd 660.0 nM
C[C@@H]1CN(c2snc3cc(-c4ccccc4)cnc23)C[C@H](C)O1 CHEMBL4642436 IC50 661.0 nM
C1=N/C2=N/c3ccc(OCCN4CCCC4)c(c3)COC/C=C/COCc3cccc(c3)C(=C1)N2 CHEMBL2035187 Kd apparent 674.0 nM
Cn1c(=O)c(Oc2ccc(F)cc2F)cc2cnc(NC3CCOCC3)nc21 CHEMBL1230122 Kd 680.0 nM
COc1ccc(-c2cnc3c(-c4ccccc4)cnn3c2)cc1OC CHEMBL5221103 Kd 690.0 nM
C#Cc1cccc(Nc2ncnc3cc4c(cc23)OCCOCCOCCO4)c1 CHEMBL2087361 Kd apparent 725.0 nM
COc1ccc(-c2cnc3c(-c4ccccc4)snc3c2)cc1OC CHEMBL4576567 Kd 770.0 nM
CN(CC(F)(F)F)S(=O)(=O)NCc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 CHEMBL4561238 Ki 780.0 nM
COc1cc(-c2cnc3c(N4CCOC[C@H]4C)snc3c2)ccc1N CHEMBL4161901 Kd 800.0 nM
CC(C)C[C@](C)(N)COc1ccc(-c2ccnc(C(F)F)c2)nc1C(F)F CHEMBL5089410 IC50 800.0 nM
N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL1078178 Kd apparent 822.0 nM
Cc1cc(-c2cc(OC(=O)c3ccccc3)ccc2Cl)cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12 CHEMBL403989 Kd apparent 824.0 nM
COc1ccc(-c2cnc3c(-c4ccsc4)snc3c2)cc1OC CHEMBL4579614 Kd 860.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 870.0 nM
O=C(Nc1n[nH]c2cc(-c3cccc(NS(=O)(=O)CC4CC4)c3)ccc12)C1CC1 CHEMBL4534959 Ki 870.0 nM
COc1ccc(-c2cnc3c(N4CCCN(C)CC4)snc3c2)cc1OC CHEMBL3753857 Kd 900.0 nM
CCC(=O)NC1CCCN(c2snc3cc(-c4ccc(N)c(OC)c4)cnc23)C1 CHEMBL4798132 IC50 900.0 nM
COc1cc(-c2cnc3c(N4CCCCC4)snc3c2)ccc1N CHEMBL4166209 Kd 970.0 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL941 Kd 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM