CCC1CCC2(C1)N=C(Nc1nc3ccccc3o1)NC1=C2C(=O)CCC1 CHEMBL1393992 IC50 0.0 nM
O=C1CCCC2=C1C(c1n[nH]cc1Br)N=C(Nc1nc3ccccc3o1)N2 CHEMBL3899970 IC50 0.0 nM
CC1=C(C(=O)Nc2nc3ccccc3o2)C2(CCCC2)N=C(Nc2nc3ccccc3o2)N1 CHEMBL5089592 IC50 0.0 nM
CC1=C(C(=O)Nc2noc3ccccc23)C(c2nn(C)cc2Cl)N=C(Nc2nc3ccccc3o2)N1 CHEMBL5084931 IC50 0.0 nM
O=C1CCCC2=C1C1(CCCC1)N=C(Nc1nc3ccccc3n1Cc1ccccc1)N2 CHEMBL1705947 IC50 0.0 nM
CC1=C(C(=O)NCc2cnn(C)c2)C(c2ccc(C)cc2Cl)N=C(Nc2nc3ccc(F)c(N)c3o2)N1 CHEMBL5088290 IC50 48.0 nM
CCn1cc(CNC(=O)C2=C(C)NC(Nc3nc4ccc(F)c(N)c4o3)=NC2c2ccc(C)cc2Cl)cn1 CHEMBL5073602 IC50 48.0 nM
CCn1cc(C(C)NC(=O)C2=C(C)NC(Nc3nc4cccc(N)c4o3)=NC2c2ccc(C)cc2Cl)cn1 CHEMBL5092879 IC50 50.0 nM
CCn1cc(CNC(=O)C2=C(C)NC(Nc3nc4ccc(F)c(N)c4o3)=N[C@H]2c2ccc(C)cc2Cl)cn1 CHEMBL5087686 IC50 68.0 nM
CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)[C@H](c2ccccc2Cl)N=C(Nc2nc3cccc(N)c3o2)N1 CHEMBL5078070 IC50 86.0 nM
CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)[C@H](c2ccc(C)cc2Cl)N=C(Nc2nc3cccc(N)c3o2)N1 CHEMBL5078166 IC50 90.0 nM
CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)C(c2ccc(-c3cnc(C)nc3)cc2Cl)N=C(Nc2nc3ccc(F)cc3o2)N1 CHEMBL5089409 IC50 110.0 nM
CCn1ncc(CNC(=O)C2=C(C)NC(Nc3nc4ccc(F)c(N)c4o3)=NC2c2ccc(C)cc2Cl)c1F CHEMBL5092268 IC50 110.0 nM
CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)C(c2ccc(-n3ccnc3)cc2Cl)N=C(Nc2nc3ccc(F)cc3o2)N1 CHEMBL5072646 pIC50 117.49 nM
CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)C(c2ccc(C)cc2Cl)N=C(Nc2nc3cccc(N)c3o2)N1 CHEMBL5092901 IC50 120.0 nM
CC1=C(C(=O)NCc2cnn(C)c2)[C@H](c2ccc(C)cc2Cl)N=C(Nc2nc3cccc(N)c3o2)N1 CHEMBL5075869 pIC50 120.23 nM
COc1ccc(C2N=C(Nc3nc4cccc(N)c4o3)NC(C)=C2C(=O)Nc2cc(C(=O)O)ccn2)c(Cl)c1 CHEMBL5086925 IC50 140.0 nM
CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)[C@H](c2ccc(C)cc2Cl)N=C(Nc2nc3ccc(F)cc3o2)N1 CHEMBL5082388 IC50 150.0 nM
COc1ccc([C@@H]2N=C(Nc3nc4cccc(N)c4o3)NC(C)=C2C(=O)Nc2cc(C(=O)O)ccn2)c(Cl)c1 CHEMBL5078058 IC50 150.0 nM
CCn1cc(CNC(=O)C2=C(C)NC(Nc3nc4cccc(N)c4o3)=NC2c2ccc(C)cc2Cl)cn1 CHEMBL5077147 IC50 170.0 nM
CC1=C(C(=O)NCc2cnn(CC(F)(F)F)c2)C(c2ccc(C)cc2Cl)N=C(Nc2nc3ccc(F)c(N)c3o2)N1 CHEMBL5094940 IC50 190.0 nM
CCn1cc(CNC(=O)C2=C(C)NC(Nc3nc4ccc(F)c(N)c4o3)=NC2c2ccccc2Cl)cn1 CHEMBL5086508 IC50 190.0 nM
CC1=C(C(=O)NCc2cnn(C)c2)C(c2ccc(C)cc2Cl)N=C(Nc2nc3cccc(N)c3o2)N1 CHEMBL5087173 pIC50 208.93 nM
CCn1nc(-c2cccs2)nc2c(=O)n(C)c(=O)nc1-2 CHEMBL555689 Potency 211.1 nM
CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)C(c2ccccc2Cl)N=C(Nc2nc3cccc(N)c3o2)N1 CHEMBL5094206 IC50 220.0 nM
CC1=C(C(=O)NCc2cnn(C)c2)C(c2ccc(Cl)cc2Cl)N=C(Nc2nc3ccc(F)c(N)c3o2)N1 CHEMBL5080517 IC50 220.0 nM
CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)[C@H](c2ccccc2Cl)N=C(Nc2nc3ccc(F)cc3o2)N1 CHEMBL5092284 IC50 240.0 nM
COc1ccc([C@@H]2N=C(Nc3nc4ccc(F)cc4o3)NC(C)=C2C(=O)Nc2cc(C(=O)O)ccn2)c(Cl)c1 CHEMBL5077548 IC50 250.0 nM
CCn1cc(CNC(=O)C2=C(C)NC(Nc3nc4ccc(F)c(N)c4o3)=NC2c2ccc(Cl)cc2Cl)cn1 CHEMBL5080286 IC50 270.0 nM
CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)C(c2ccc(-c3ccc(C)nc3)cc2Cl)N=C(Nc2nc3ccc(F)cc3o2)N1 CHEMBL5081118 IC50 340.0 nM
CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)C(c2ccc(C)cc2Cl)N=C(Nc2nc3ccc(F)cc3o2)N1 CHEMBL5090335 pIC50 389.05 nM
CC1=C(C(=O)NCc2cnn(C)c2)C(c2ccccc2Cl)N=C(Nc2nc3cccc(N)c3o2)N1 CHEMBL5091242 IC50 390.0 nM
CC1=C(C(=O)NCc2cnn(Cc3ccccc3)c2)C(c2ccc(C)cc2Cl)N=C(Nc2nc3cccc(N)c3o2)N1 CHEMBL5080865 IC50 390.0 nM
COc1ccc(C2N=C(Nc3nc4ccc(F)cc4o3)NC(C)=C2C(=O)Nc2cc(C(=O)O)ccn2)c(Cl)c1 CHEMBL5088230 IC50 430.0 nM
CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)C(c2ccc(N3CCOCC3)cc2Cl)N=C(Nc2nc3ccc(F)cc3o2)N1 CHEMBL5085360 IC50 430.0 nM
CCn1nc(C)c(CNC(=O)C2=C(C)NC(Nc3nc4ccc(F)c(N)c4o3)=NC2c2ccc(C)cc2Cl)c1F CHEMBL5080203 IC50 430.0 nM
CCn1cc(CNC(=O)C2=C(C)NC(Nc3nc4cccc(N)c4o3)=NC2c2ccc(Cl)cc2Cl)cn1 CHEMBL5079108 IC50 480.0 nM
CC1=C(C(=O)NCc2cnn(C)c2C)C(c2ccc(C)cc2Cl)N=C(Nc2nc3ccc(F)cc3o2)N1 CHEMBL5082061 IC50 490.0 nM
CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)C(c2ccccc2Br)N=C(Nc2nc3ccc(F)cc3o2)N1 CHEMBL5091860 IC50 540.0 nM
CCn1cc(C(C)NC(=O)C2=C(C)NC(Nc3nc4cccc(N)c4o3)=NC2c2ccc(Cl)cc2Cl)cn1 CHEMBL5089695 IC50 540.0 nM
CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)[C@H](c2ccccc2Cl)N=C(Nc2nc3ccccc3o2)N1 CHEMBL5094774 IC50 540.0 nM
CCn1nc(-c2ccccc2)nc2c(=O)n(C)c(=O)nc1-2 CHEMBL1488035 Potency 595.1 nM
O=C1CCCC2=C1C(c1ccccc1Cl)N=C(Nc1nc3ccccc3o1)N2 CHEMBL1550982 Potency 595.1 nM
CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)C(c2ccc(C#N)cc2Cl)N=C(Nc2nc3ccc(F)cc3o2)N1 CHEMBL5081986 IC50 610.0 nM
CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)C(c2ccccc2Cl)N=C(Nc2nc3ccc(F)cc3o2)N1 CHEMBL5079293 pIC50 630.96 nM
O=C1CCCC2=C1C(c1ncccc1Br)N=C(Nc1nc3ccccc3o1)N2 CHEMBL3982313 IC50 650.6 nM
CC1=C(C(=O)Nc2ccc(C(=O)O)cn2)C(c2ccccc2Cl)N=C(Nc2nc3ccc(F)cc3o2)N1 CHEMBL5085878 IC50 680.0 nM
CC1=C(C(=O)NCc2cnn(C)c2)C(c2ccc(F)cc2Cl)N=C(Nc2nc3cccc(N)c3o2)N1 CHEMBL5080696 IC50 680.0 nM
CCOc1ccc(C2N=C(Nc3nc4ccc(F)cc4o3)NC(C)=C2C(=O)Nc2cc(C(=O)O)ccn2)c(Cl)c1 CHEMBL5081849 IC50 690.0 nM
N#CC1=C(SCc2ccccc2)SC(c2cc(O)ccc2O)NC1=O CHEMBL2017798 IC50 700.0 nM
O=C1CCCC2=C1C(c1ccccc1Br)N=C(Nc1nc3ccccc3o1)N2 CHEMBL3923544 IC50 749.2 nM
CCn1cc(CNC(=O)C2=C(C)NC(Nc3nc4cccc(N)c4o3)=NC2c2ccc(F)cc2Cl)cn1 CHEMBL5081912 IC50 760.0 nM
CC1=C(C(=O)Nc2cc(-c3nn[nH]n3)ccn2)C(c2ccccc2Cl)N=C(Nc2nc3ccc(F)cc3o2)N1 CHEMBL5088626 IC50 770.0 nM
CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)C(c2ccc(-n3cccn3)cc2Cl)N=C(Nc2nc3ccc(F)cc3o2)N1 CHEMBL5084901 IC50 770.0 nM
CC1=C(C(=O)NCc2cnn(C(C)(C)C)c2)C(c2ccc(C)cc2Cl)N=C(Nc2nc3ccc(F)c(N)c3o2)N1 CHEMBL5083535 IC50 770.0 nM
CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)C(c2ccc(F)cc2Cl)N=C(Nc2nc3ccc(F)cc3o2)N1 CHEMBL5081119 IC50 860.0 nM
CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)C(c2ccc(C)cc2Cl)N=C(Nc2nc3cnccc3o2)N1 CHEMBL5083925 IC50 860.0 nM
N#CC1=C(SCc2cccc(N3CCOCC3)c2)SC(c2cc(O)ccc2O)NC1=O CHEMBL2017800 IC50 900.0 nM
CC1=C(C(=O)Nc2cc(C(=O)O)ccn2)C(c2ccccc2Cl)N=C(Nc2nc3cccc(C)c3o2)N1 CHEMBL5094727 pIC50 933.25 nM
CCCc1nc2c(=O)n(C)c(=O)nc-2n(C)n1 CHEMBL1325945 Potency 943.1 nM