O=C1/C(=N/c2cccc(C(F)(F)F)c2)c2ccccc2N1c1cccc(OCCN2CCCC2)c1 CHEMBL209497 Ki 5.0 nM
CC(C)(C)c1ccc(CSc2cnn(C(C)(C)C)c(=O)c2Cl)cc1 CHEMBL225963 IC50 6.57 nM
O=C1/C(=N/c2cccc(C(F)(F)F)c2)c2ccccc2N1c1cccc(OCCN2CCCCC2)c1 CHEMBL209498 Ki 8.0 nM
CCN(CC)CC(O)COc1cccc(N2C(=O)/C(=N/c3cccc(C(F)(F)F)c3)c3ccccc32)c1 CHEMBL378991 Ki 15.0 nM
CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O CHEMBL503473 Kd 15.0 nM
COc1cc2c(cc1OC)[C@@H]1C(=O)c3ccc4c(c3O[C@@H]1CO2)C[C@H](C(C)C)O4 CHEMBL267630 IC50 15.41 nM
O=C1/C(=N/c2cccc(C(F)(F)F)c2)c2ccccc2N1c1ccccc1 CHEMBL210288 Ki 17.0 nM
CC[C@@H]1CCC[C@@H](O)[C@@H](C)C(=O)O[C@H](C)[C@@H](C)C/C=C(C)/C(OC)=C\C(=O)N(C)C([C@@H](C)CC)C(=O)N(C)[C@@H](C(C)C)C(=O)N(C)[C@@H](COC)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](C(C)C)C(=O)N2CCC[C@H]2C(=O)O1 CHEMBL1873644 IC50 17.14 nM
CCN(CC)CCCOc1cccc(N2C(=O)/C(=N/c3cccc(C(F)(F)F)c3)c3ccccc32)c1 CHEMBL378825 Ki 21.0 nM
CN(C)CCOc1cccc(N2C(=O)/C(=N/c3cccc(C(F)(F)F)c3)c3ccccc32)c1 CHEMBL211398 Ki 26.0 nM
CCN(CC)C[C@H](O)COc1cccc(N2C(=O)/C(=N/c3cccc(C(F)(F)F)c3)c3ccccc32)c1 CHEMBL209642 Ki 27.0 nM
CN(C)CCCOc1cccc(N2C(=O)/C(=N/c3cccc(C(F)(F)F)c3)c3ccccc32)c1 CHEMBL377468 Ki 29.0 nM
CCN(CC)CCCOc1ccc(N2C(=O)/C(=N/c3cccc(C(F)(F)F)c3)c3ccccc32)cc1 CHEMBL213893 Ki 34.0 nM
CCN(CC)COc1cccc(N2C(=O)/C(=N/c3cccc(C(F)(F)F)c3)c3ccccc32)c1 CHEMBL383941 Ki 38.0 nM
COc1cc2c(cc1OC)C1C(=O)c3ccc4c(c3OC1CO2)CC(C(C)C)O4 CHEMBL1721226 IC50 38.65 nM
CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(N)=O CHEMBL526003 Kd 40.0 nM
CCN(CC)CCCCOc1cccc(N2C(=O)/C(=N/c3cccc(C(F)(F)F)c3)c3ccccc32)c1 CHEMBL209476 Ki 45.0 nM
O=C1/C(=N/c2cccc(C(F)(F)F)c2)c2ccccc2N1c1cccc(OCCCN2CCCC2)c1 CHEMBL211031 Ki 49.0 nM
CCC(CC)N1C(=O)/C(=N/c2ccc(C(F)(F)F)cc2)c2ccccc21 CHEMBL211169 Ki 52.0 nM
CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(C)C)C(=O)N[C@H](C(=O)O)[C@@H](C)O CHEMBL499179 Kd 69.0 nM
CCN(CC)CCCCOc1ccc(N2C(=O)/C(=N/c3cccc(C(F)(F)F)c3)c3ccccc32)cc1 CHEMBL377328 Ki 70.0 nM
CCN(CC)CCOc1ccc(N2C(=O)/C(=N/c3cccc(C(F)(F)F)c3)c3ccccc32)cc1 CHEMBL211467 Ki 78.0 nM
O=C(CSc1nnnn1C1CC2CCC1C2)Nc1ccnc2ccccc12 CHEMBL1423004 IC50 86.87 nM
CCN(CC)CCOc1cccc(N2C(=O)/C(=N/c3cccc(C(F)(F)F)c3)c3ccccc32)c1 CHEMBL209481 Ki 87.0 nM
C#CCN1C(=O)/C(=N/c2cccc(C(F)(F)F)c2)c2ccccc21 CHEMBL387401 Ki 89.0 nM
CN(C)CCOc1ccc(N2C(=O)/C(=N/c3cccc(C(F)(F)F)c3)c3ccccc32)cc1 CHEMBL209730 Ki 89.0 nM
COc1ccc(CNC(=O)c2cccc3c(-c4cccnc4)coc23)cc1OC CHEMBL1878609 IC50 126.34 nM
COc1ccccc1N1C(C)=CC(=Cc2sc3ccccc3[n+]2C)C=C1C CHEMBL1323872 IC50 128.28 nM
CC(Nc1ncnc2ccccc12)c1ccccc1 CHEMBL1550278 IC50 128.42 nM
Cc1nc2ccccc2n1Cc1ccc(Br)cc1 CHEMBL1725453 IC50 140.16 nM
Fc1ccc(N=C(S)N2CCCN(c3ccc(C(F)(F)F)cn3)CC2)c(F)c1 CHEMBL1386344 IC50 142.05 nM
Cn1nccc1C(=O)NC1CCCc2c1cnn2-c1ccc(C(C)(C)C)cc1 CHEMBL1461631 IC50 143.0 nM
CCCCCn1c(=O)[nH]c2cc(C(=O)N3CCN(Cc4ccc5c(c4)OCO5)CC3)ccc2c1=O CHEMBL1319304 IC50 147.93 nM
C=CCN1C(=O)/C(=N/c2ccc(Cl)c(Cl)c2)c2ccccc21 CHEMBL212729 Ki 150.0 nM
Cc1nn(C)c(Nc2ccc(Br)cc2)c1Br CHEMBL1499354 IC50 154.72 nM
Cc1nn(C)c(C(=O)NCc2ccc(Cl)cc2)c1Cl CHEMBL1340112 IC50 157.61 nM
Cc1ccc(Oc2ccc(OCC(=O)Nc3ccncc3)cc2)cc1 CHEMBL1705098 IC50 158.36 nM
Cc1nc2ccccc2n1Cc1ccc(Cl)cc1 CHEMBL152649 IC50 203.24 nM
Cn1nccc1C(=O)NC1CCCc2c1cnn2-c1ccc(F)cc1F CHEMBL1492752 IC50 240.04 nM
COc1ccc(N2C(C)=CC(=Cc3sc4ccccc4[n+]3C)C=C2C)cc1 CHEMBL1422429 IC50 246.39 nM
CC1CC(=O)NN=C1c1ccc(N)c([N+](=O)[O-])c1 CHEMBL1546066 IC50 260.46 nM
CCN(CC)C[C@@H](O)COc1cccc(N2C(=O)/C(=N/c3cccc(C(F)(F)F)c3)c3ccccc32)c1 CHEMBL211522 Ki 290.0 nM
NC(=O)c1nnn(Cc2cc(Cl)c(C(=O)c3ccc(Cl)cc3)c(Cl)c2)c1N CHEMBL95431 IC50 303.14 nM
CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)O CHEMBL499980 Kd 315.0 nM
Cc1cc(CSc2ccccc2)ccc1NC(=O)c1ccc(CN2CCOCC2)cc1 CHEMBL1425552 IC50 322.09 nM
Cc1ccccc1Cn1c(C)nc2ccccc21 CHEMBL1604200 IC50 330.65 nM
OC[C@@H]1CN(Cc2ccc(-c3ccccc3)cc2)C[C@H](n2cnc3c(NC4CCCC4)ncnc32)O1 CHEMBL1903414 IC50 348.52 nM
COc1ccc(-c2coc3c(C(=O)NCc4ccc(OC)c(OC)c4)cccc23)c(C)c1 CHEMBL1981589 IC50 358.39 nM
Cc1cc(C)c(CN2CCN(C(=O)Cn3cnc4c(NCc5ccccc5)ncnc43)CC2)c(C)c1 CHEMBL1711360 IC50 362.58 nM
CC1CC(=O)NN=C1c1ccc(NCCO)c([N+](=O)[O-])c1 CHEMBL1569489 IC50 367.22 nM
COc1ccc(CCNc2ncnc3sccc23)cc1OC CHEMBL1423660 IC50 371.44 nM
COc1cccc2[nH]c3c(N4CCC(C)CC4)ncnc3c12 CHEMBL1400272 IC50 378.74 nM
C1=C(CCNc2[nH]cnc3c4ccccc4nc2-3)CCCC1 CHEMBL1428566 IC50 382.84 nM
Nc1nc2ccccc2cc1C(=O)NCc1ccc(-c2ccccc2)cc1 CHEMBL2136916 IC50 391.72 nM
O=C(COc1ccc(C(=O)c2ccccc2)cc1)Nc1cccnc1 CHEMBL1424583 IC50 399.11 nM
COc1cccc2[nH]c3c(N4CCCC(C)C4)ncnc3c12 CHEMBL1300327 IC50 399.9 nM
O=C(Nc1ccc(Oc2ccccc2)cc1)c1csc([C@H]2C[C@H](O)[C@@H](CO)O2)n1 CHEMBL2355112 IC50 400.33 nM
CC[n+]1c(/C=C2\SC(c3ccccc3C)=CN2C)sc2ccccc21 CHEMBL1462215 IC50 403.97 nM
CC(C)(C)c1ccc(-n2ncc3c2CCCC3NC(=O)C2(C(N)=O)CC2)cc1 CHEMBL1610300 IC50 407.86 nM
COc1ccc(CN(C)c2ccc(S(=O)(=O)N3CCN(C)CC3)cc2[N+](=O)[O-])cc1OC CHEMBL1437030 IC50 419.43 nM
COc1ccc(CCNc2ncnc3sc(C)cc23)cc1OC CHEMBL1603001 IC50 430.23 nM
O=C1Nc2ccccc2/C1=N\c1cccc(Cl)c1Cl CHEMBL378877 Ki 437.0 nM
CCOC(=O)CC1CCCCN1C(=O)c1cc(COc2cccc3cnccc23)on1 CHEMBL1405288 IC50 447.54 nM
CCN(CC)S(=O)(=O)c1cc(NC(=O)CNc2cccc(S(=O)(=O)N3CCOCC3)c2)ccc1C CHEMBL1493864 IC50 449.14 nM
O=c1cc(CSc2nnc(-c3cccs3)n2Cc2ccccc2)nc2sc3ccccc3n12 CHEMBL1413056 IC50 482.08 nM
CC(=O)OCC1OC(n2c(S)c(C#N)c(-c3ccccc3)c(C#N)c2=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O CHEMBL1884207 IC50 502.85 nM
NC(=O)c1c(-c2ccc(Cl)cc2Cl)csc1NC(=O)Cc1ccccc1 CHEMBL1446412 IC50 512.94 nM
COc1c(/C=C2\SC(Nc3ccccc3Cl)=NC2=O)cccc1[N+](=O)[O-] CHEMBL1494282 IC50 546.97 nM
CCOc1cc(S(=O)(=O)NCc2ccncc2)ccc1Cl CHEMBL1490503 IC50 580.9 nM
O=C1Nc2ccccc2/C1=N\c1cccc(C(F)(F)F)c1 CHEMBL209480 Ki 596.0 nM
CC(=O)OCC[N+](C)(C)C CHEMBL1736587 IC50 617.81 nM
Cc1ccc(CCNc2ncnc(Cl)c2N)cc1 CHEMBL1717339 IC50 626.1 nM
COc1ccc(-n2c(C)cc(C(=O)COC(=O)Cn3cnc4ccccc43)c2C)cc1 CHEMBL1376266 IC50 762.09 nM
O=C1/C(=N/c2cccc(C(F)(F)F)c2)c2ccccc2N1c1ccccc1OCCN1CCCC1 CHEMBL425250 Ki 790.0 nM
CC1(C)CC2CC(C)(CN2S(=O)(=O)c2ccc(C(=O)Nc3cccc(S(=O)(=O)N4CCOCC4)c3)cc2)C1 CHEMBL1380444 IC50 804.68 nM
O=C1Nc2ccccc2/C1=N\c1ccc(Cl)cc1 CHEMBL209737 Ki 850.0 nM
Cc1cc(C)nc(SCC(=O)Nc2ccnc3ccccc23)n1 CHEMBL1487720 IC50 873.62 nM
CCn1cc(C(=O)NC2CCCc3c2cnn3-c2cccc(C)c2C)cn1 CHEMBL1412747 IC50 874.17 nM
COc1ccc(C(=O)CSc2nnc(Cn3cnc4ccccc43)o2)cc1 CHEMBL1557584 IC50 890.66 nM
CC(NCCc1ccc(O)cc1)C(O)c1ccc(O)cc1 CHEMBL83063 IC50 932.0 nM
CC1(C)CC2CC(C)(CN2S(=O)(=O)c2ccc(C(=O)Nc3ccc(S(=O)(=O)N4CCOCC4)cc3)cc2)C1 CHEMBL1544054 IC50 960.0 nM
Cc1ccccc1-c1cc(C(=O)Nc2sc(C(=O)OC(C)C)c(C)c2C#N)c2ccccc2n1 CHEMBL1414465 IC50 967.0 nM
Cn1nc(C(C)(C)C)cc1C(=O)NCc1cc(F)cc2c1OCOC2 CHEMBL1533321 IC50 987.0 nM
CCCCc1ccc(NC(=O)c2ccc(N(C)S(C)(=O)=O)cc2)cc1 CHEMBL1399125 IC50 996.0 nM
CCN(CC)CCOc1ccccc1N1C(=O)/C(=N/c2cccc(C(F)(F)F)c2)c2ccccc21 CHEMBL212224 Ki 1000.0 nM