CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.488 nM
CN1C(=O)CCC1c1cc2[nH]c(-c3ccccn3)cc2cc1Oc1ccc(S(C)(=O)=O)nc1 CHEMBL4067028 EC50 0.8 nM
Cn1cc(-c2cc(C(O)(C(F)(F)F)C(F)(F)F)cnc2N2CCN(S(=O)(=O)c3ccc(N)nc3)CC2)cn1 CHEMBL3319533 IC50 1.0 nM
Cc1cnc(-c2cc3cc(Oc4ccc(S(C)(=O)=O)nc4)c(C4CCC(=O)N4C)cc3[nH]2)s1 CHEMBL4086771 EC50 1.0 nM
CCS(=O)(=O)c1ccc(Oc2cc3cc(-c4ccc(C(F)(F)F)cn4)[nH]c3cc2C2CCC(=O)N2C)cc1 CHEMBL4086782 EC50 1.4 nM
CCS(=O)(=O)c1ccc(Oc2cc3cc(-c4ccc(CCC(=O)OC)cn4)[nH]c3cc2C2CCC(=O)N2C)cc1 CHEMBL3918883 EC50 1.9 nM
CC(O)(c1ccc(N2CCN(S(=O)(=O)c3cccs3)C[C@@H]2CN2C3CCC2COC3)cc1)C(F)(F)F CHEMBL3113985 IC50 2.0 nM
COC(=O)CCc1ccc(Oc2cc3cc(-c4cnccn4)[nH]c3cc2C2CCC(=O)N2C)cc1 CHEMBL3893442 EC50 2.1 nM
CN1C(=O)CCC1c1cc2[nH]c(-c3ccc(C(C)(C)O)cn3)cc2cc1Oc1ccc(S(C)(=O)=O)nc1 CHEMBL4068048 EC50 2.1 nM
C[C@@H](CO)Oc1cc(Oc2ccc(C(=O)N3CCC3)cc2)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL3217925 Kd 2.16 nM
CN1C(=O)CCC1c1cc2[nH]c(-c3ccc(C(F)(F)F)cn3)cc2cc1Oc1ccc(S(C)(=O)=O)nc1 CHEMBL4083339 EC50 2.4 nM
Cc1ccc(NC(=O)c2cc(Oc3ccc(C(=O)N4CCC4)c(F)c3)c3c(c2)OC(C)(CO)C3)nc1 CHEMBL3580738 Kd 2.42 nM
CCS(=O)(=O)c1ccc(Oc2cc(O[C@@H](C)CO)cc(C(=O)Nc3ccn(C)n3)c2)cn1 CHEMBL3580737 Kd 2.93 nM
COC(=O)c1ccc(-c2cc3cc(Oc4ccc(S(C)(=O)=O)nc4)c(C4CCC(=O)N4C)cc3[nH]2)nc1 CHEMBL4104680 EC50 3.4 nM
COC(=O)CCc1ccc(-c2cc3cc(Oc4ccc(S(C)(=O)=O)cc4)c(C4CCC(=O)N4C)cc3[nH]2)nc1 CHEMBL3901777 EC50 3.8 nM
CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1 CHEMBL3114185 IC50 4.0 nM
CN1C(=O)CCC1c1cc2[nH]c(-c3cnccn3)cc2cc1Oc1ccc(S(C)(=O)=O)nc1 CHEMBL4078915 EC50 4.2 nM
COC(=O)CCc1ccc(Oc2cc3cc(-c4ccccn4)[nH]c3cc2C2CCC(=O)N2C)cc1 CHEMBL3969091 EC50 4.3 nM
CCOC(=O)c1ccc(Oc2cc3cc(-c4ccc(C(F)(F)F)cn4)[nH]c3cc2C2CCC(=O)N2C)cc1 CHEMBL4067037 EC50 4.8 nM
CCNC(=O)Cc1csc(NC(=O)c2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(-c3ncccc3C)c2)n1 CHEMBL3235148 EC50 5.0 nM
COCC#Cc1cc(C(O)(C(F)(F)F)C(F)(F)F)cnc1N1CCN(S(=O)(=O)c2ccc(N)nc2)CC1 CHEMBL3319529 IC50 5.0 nM
Nc1ccc(S(=O)(=O)N2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)cc3-c3cccnc3)CC2)cn1 CHEMBL3319549 IC50 5.0 nM
Cc1csc(-c2cc(C(O)(C(F)(F)F)C(F)(F)F)cnc2N2CCN(S(=O)(=O)c3ccc(N)nc3)CC2)c1 CHEMBL3319540 IC50 5.0 nM
CCn1cc(-c2cc(C(O)(C(F)(F)F)C(F)(F)F)cnc2N2CCN(S(=O)(=O)c3ccc(N)nc3)CC2)cn1 CHEMBL3319534 IC50 5.0 nM
COc1ccc(Sc2ccc(Sc3ccccn3)nc2C(=O)Nc2nc(CC(=O)O)c(Cl)s2)cc1 CHEMBL4092800 EC50 5.7 nM
CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc([C@](C)(O)C(F)(F)F)cc1 CHEMBL3114186 IC50 6.0 nM
CC#CC1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1 CHEMBL3114183 IC50 6.0 nM
Nc1ccc(S(=O)(=O)N2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)cc3-c3ccccc3O)CC2)cn1 CHEMBL3319544 IC50 6.0 nM
COC[C@H](C)Oc1cc(C#CCOC2CCCCO2)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL3577715 EC50 6.0 nM
COC[C@H](C)Oc1cc(C#Cc2cccc(NCCN(C)C)c2)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL3577727 EC50 6.0 nM
COC[C@H](C)Oc1cc(C#Cc2cccc(NCCN3CCCC3)c2)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL3577728 EC50 6.0 nM
COC[C@H](C)Oc1cc(C#Cc2cccc(NCCN3CCCCC3)c2)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL3577729 EC50 6.0 nM
COC[C@H](C)Oc1cc(C#Cc2cccc(OCCN3CCCC3)c2)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL3577735 EC50 6.0 nM
C[C@H]1COCCN1C[C@H]1CN(S(=O)(=O)c2cccs2)CCN1c1ccc(C(C)(O)C(F)(F)F)cc1 CHEMBL3113980 IC50 7.0 nM
Nc1ccc(S(=O)(=O)N2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)cc3-c3ccccc3F)CC2)cn1 CHEMBL3319542 IC50 7.0 nM
Nc1ccc(S(=O)(=O)N2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)cc3-c3ccccc3)CC2)cn1 CHEMBL3319541 IC50 7.0 nM
COC[C@H](C)Oc1cc(C#Cc2cccc(OCCN3CCCCC3)c2)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL3577736 EC50 7.0 nM
COCC(C)NCc1csc(NC(=O)c2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(-c3ncccc3C)c2)n1 CHEMBL3235155 EC50 8.0 nM
Nc1ccc(S(=O)(=O)N2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)cc3-c3cccc(F)c3)CC2)cn1 CHEMBL3319543 IC50 8.0 nM
COC(=O)CCc1cnc(-c2cc3cc(Oc4ccc(S(C)(=O)=O)cc4)c(C4CCC(=O)N4C)cc3[nH]2)s1 CHEMBL3895061 EC50 8.9 nM
CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc([C@@](C)(O)C(F)(F)F)cc1 CHEMBL3114187 IC50 9.0 nM
COC[C@H](C)Oc1cc(C#Cc2cccc(NCCn3ccnc3C)c2)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL3577732 EC50 9.0 nM
CC(=O)N1CCC(c2nsc(Nc3ncc(Sc4ccccn4)cc3Oc3cccc4ncccc34)n2)CC1 CHEMBL4643627 EC50 9.3 nM
CN1C(=O)CCC1c1cc2[nH]c(-c3ccc(C(F)(F)F)cn3)cc2cc1Oc1ccc(C(=O)O)cc1 CHEMBL4094511 EC50 9.6 nM
O=C(O)Cc1nc(NC(=O)c2nc(Sc3ccccn3)ccc2Sc2ccc(F)cc2)sc1Cl CHEMBL4065127 EC50 9.6 nM
Cc1cccc(C#N)c1Oc1ccc2ncnc(Nc3ccn(C)n3)c2c1 CHEMBL572840 EC50 10.0 nM
CCN1CCC(c2ncc(-c3cnc(N)c(OCc4ccncc4)c3)s2)CC1 CHEMBL4793665 IC50 10.2 nM
COC[C@H](C)Oc1cc(Oc2cnc(C(=O)N3CCC3)cn2)cc(C(=O)Nc2cnc(C)cn2)c1 CHEMBL3219124 Kd 10.8 nM
Nc1ccc(S(=O)(=O)N2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)cc3-c3cncc(F)c3)CC2)cn1 CHEMBL3319551 IC50 11.0 nM
Nc1ccc(S(=O)(=O)N2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)cc3-c3ccc(F)cc3)CC2)cn1 CHEMBL3317472 IC50 11.0 nM
COC(=O)CCc1ccc(Oc2cc3cc(-c4ccc(C(F)(F)F)cn4)[nH]c3cc2C2CCC(=O)N2C)cc1 CHEMBL3896295 EC50 11.4 nM
COC[C@H](C)Oc1cc(C#Cc2ccc3[nH]ccc3c2)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL3577720 EC50 12.0 nM
CS(=O)(=O)c1ccc(/C(=C/C2CCCC2)c2cc3cccnc3[nH]2)cc1Cl CHEMBL3764079 EC50 12.4 nM
COC(=O)CCc1ccc(-c2cc3cc(Oc4ccc(C(=O)N5CCC5)nc4)c(C4CCCN4C(C)=O)cc3[nH]2)nc1 CHEMBL3977813 EC50 13.9 nM
C[C@@](O)(c1ccc(N2CCN(S(=O)(=O)c3cccs3)C[C@@H]2CN2[C@H]3COC[C@@H]2[C@H](O)C3)cc1)C(F)(F)F CHEMBL3113988 IC50 14.0 nM
CCc1ncccc1Oc1cc(CC2CCCCC2)cnc1NC(=O)NC CHEMBL3358432 EC50 14.0 nM
Nc1ccc(S(=O)(=O)N2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)cc3C#CCO)CC2)cn1 CHEMBL3319528 IC50 14.0 nM
COc1ccc(Sc2ccc(Sc3ccccn3)nc2C(=O)Nc2ncc(SCC(=O)O)s2)cc1 CHEMBL4084078 EC50 14.0 nM
CCOc1ccc(-c2cnc(NC(=O)NC)cc2Oc2c(F)cccc2F)cn1 CHEMBL4528539 EC50 14.0 nM
Cc1nc2cc(-c3cc(C(O)(C(F)(F)F)C(F)(F)F)cnc3N3CCN(S(=O)(=O)c4ccc(N)nc4)CC3)ccc2o1 CHEMBL3319559 IC50 15.0 nM
CN1C(=O)CCC1c1cc2[nH]c(-c3ccccn3)cc2cc1Oc1ccc(CCC(=O)O)cc1 CHEMBL3908999 EC50 15.1 nM
C[C@](O)(c1ccc(N2CCN(S(=O)(=O)c3cccs3)C[C@@H]2CN2[C@H]3COC[C@@H]2[C@H](O)C3)cc1)C(F)(F)F CHEMBL3113989 IC50 16.0 nM
COc1ccc(-c2cc(C(O)(C(F)(F)F)C(F)(F)F)cnc2N2CCN(S(=O)(=O)c3ccc(N)nc3)CC2)cn1 CHEMBL3319554 IC50 16.0 nM
COC[C@H](C)Oc1cc(C#Cc2cccc(OCCN3CCOCC3)c2)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL3577737 EC50 16.0 nM
Nc1ccc(S(=O)(=O)N2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)cc3C#CCCO)CC2)cn1 CHEMBL3319531 IC50 17.0 nM
COc1cncc(-c2cc(C(O)(C(F)(F)F)C(F)(F)F)cnc2N2CCN(S(=O)(=O)c3ccc(N)nc3)CC2)c1 CHEMBL3319555 IC50 17.0 nM
Cc1cnc(NC(=O)c2cc(Oc3ccc(C(=O)N(C)C)nc3)c3c(c2)OC(C)(CO)C3)cn1 CHEMBL3580740 Kd 17.5 nM
Nc1ccc(S(=O)(=O)N2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)cc3-c3ccoc3)CC2)cn1 CHEMBL3319539 IC50 19.0 nM
CC(C)Oc1cc(O[C@@H](C)Cc2ccccc2)cc(C(=O)Nc2ccc(C(=O)O)cn2)c1 CHEMBL205816 EC50 20.0 nM
Cn1ccc(Nc2ncnc3ccc(Oc4ncccc4Br)cc23)n1 CHEMBL584378 EC50 20.0 nM
CCS(=O)(=O)c1ccc(Oc2cc3nc(-c4ccccn4)[nH]c3cc2CN2C(=O)COC2=O)cc1 CHEMBL596026 EC50 20.0 nM
CN1C(=O)Cc2cc(-c3cc(C(O)(C(F)(F)F)C(F)(F)F)cnc3N3CCN(S(=O)(=O)c4ccc(N)nc4)CC3)ccc21 CHEMBL3319560 IC50 20.0 nM
Nc1ccc(S(=O)(=O)N2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)cc3-c3ccc4ocnc4c3)CC2)cn1 CHEMBL3319558 IC50 20.0 nM
COC[C@H](C)Oc1cc(C#Cc2cccc(NCCN3CCOCC3)c2)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL3577730 EC50 20.0 nM
CN(C)CC(=O)N1CCC(c2nsc(Nc3ncc(Sc4ccccn4)cc3Oc3ccccc3)n2)CC1 CHEMBL4648642 EC50 20.0 nM
CCc1csc(Nc2ncc(Sc3ccncc3)cc2Oc2ccccc2)n1 CHEMBL4639271 EC50 20.0 nM
Nc1ccc(S(=O)(=O)N2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)cc3-c3ccncc3)CC2)cn1 CHEMBL3319548 IC50 21.0 nM
COC[C@H](C)Oc1cc(C#Cc2ccccc2OC)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL3577719 EC50 21.0 nM
COC(=O)Cc1ccc(Oc2cc3cc(-c4ccccn4)[nH]c3cc2C2CCC(=O)N2C)cc1 CHEMBL3979297 EC50 21.0 nM
CN(C)C(=O)N1CCC(c2nsc(Nc3ncc(Sc4ccccn4)cc3Oc3ccccc3)n2)CC1 CHEMBL4646748 EC50 21.0 nM
c1ccc(Oc2cc(Sc3ccccn3)cnc2Nc2nc(C3CCOC3)ns2)cc1 CHEMBL4646802 EC50 21.0 nM
CC(C)Oc1cc(Oc2cnc(C(=O)N3CCC3)cn2)cc(C(=O)Nc2cc[nH]n2)c1 CHEMBL3580742 Kd 21.4 nM
O=C(O)CCc1csc(Nc2ncc(Sc3ccncc3)cc2Oc2ccccc2)n1 CHEMBL4635545 EC50 22.0 nM
COc1ccc2nc(NC(=O)[C@H](CC3CCCC3)c3ccc(S(=O)(=O)N4CCN(C)CC4)cc3)sc2n1 CHEMBL575726 Activity 23.0 nM
CC(C)n1cc(-c2cc(C(O)(C(F)(F)F)C(F)(F)F)cnc2N2CCN(S(=O)(=O)c3ccc(N)nc3)CC2)cn1 CHEMBL3319535 IC50 23.0 nM
CCOP(=O)(Cc1cnc(-c2cc3cc(Oc4ccc(S(C)(=O)=O)nc4)c(C4CCC(=O)N4C)cc3[nH]2)s1)OCC CHEMBL3933975 EC50 23.5 nM
CN1C(=O)CCC1c1cc2[nH]c(-c3ccccn3)cc2cc1Oc1ccc(CC(=O)O)cc1 CHEMBL3907860 EC50 23.8 nM
Nc1ccc(S(=O)(=O)N2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)cc3-c3cnccc3F)CC2)cn1 CHEMBL3319550 IC50 24.0 nM
CCOP(=O)(Cn1ccc(NC(=O)c2cc(Oc3ccc(S(C)(=O)=O)nc3)cc(OC(C)C)c2)n1)OCC CHEMBL5084870 EC50 24.0 nM
C[C@@](O)(c1ccc(N2CCN(S(=O)(=O)c3cccs3)C[C@@H]2CN2[C@@H]3COC[C@H]2[C@@H](O)C3)cc1)C(F)(F)F CHEMBL3113990 IC50 25.0 nM
COC[C@H](C)Oc1cc(C#CCSC2CCCC2)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL3577718 EC50 25.0 nM
CCOP(=O)(Cn1ccc(NC(=O)c2cc(Oc3ccc(C(=O)N4CCC4)nc3)cc(OC(C)C)c2)n1)OCC CHEMBL5076377 EC50 25.0 nM
O=C(Nc1ncc(F)s1)[C@H](CC1CCOCC1)c1ccc(S(=O)(=O)C2CC2)cc1 CHEMBL499520 Kd 25.6 nM
CC(C)c1csc(NC(=O)[C@H](CC2CCOCC2)c2ccc(S(=O)(=O)C3CC3)cc2)n1 CHEMBL1165653 EC50 26.0 nM
CC(O)(c1ccc(N2CCN(S(=O)(=O)c3cccs3)C[C@@H]2CN2[C@H]3COC[C@H]2[C@@H](O)C3)cc1)C(F)(F)F CHEMBL3113987 IC50 26.0 nM
Cn1ccc(NC(=O)c2cc(Oc3ccc(C(=O)N4CCC4)c(F)c3)c3c(c2)OC(C)(C)C3)n1 CHEMBL3218477 EC50 26.0 nM
Nc1ccc(S(=O)(=O)N2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)cc3-c3cc4ccccc4[nH]3)CC2)cn1 CHEMBL3319564 IC50 27.0 nM
COC[C@H](C)Oc1cc(C#Cc2cccc(N)c2)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL3577723 EC50 27.0 nM
Cc1ccc(Sc2ccc(Sc3nnc[nH]3)nc2C(=O)Nc2ncns2)cn1 CHEMBL4079100 EC50 27.7 nM
CCOP(=O)(Cn1ccc(NC(=O)c2cc(Oc3ccc(S(=O)(=O)CC)cc3)cc(OC(C)C)c2)n1)OCC CHEMBL5076695 EC50 28.0 nM
CC(C)=CCOc1cc(Oc2ccc(S(=O)(=O)C3CC3)cc2)cc(C(=O)Nc2nccs2)c1 CHEMBL2022798 EC50 28.3 nM
Cc1cncc(-c2cc(C(O)(C(F)(F)F)C(F)(F)F)cnc2N2CCN(S(=O)(=O)c3ccc(N)nc3)CC2)c1 CHEMBL3319552 IC50 29.0 nM
CC(C)C(=O)N1CCC(c2nsc(Nc3ncc(Sc4ccccn4)cc3Oc3ccccc3)n2)CC1 CHEMBL4642717 EC50 29.0 nM
CCOP(=O)(Cn1ccc(NC(=O)c2cc(Oc3cnc(C(=O)N4CCC4)cn3)cc(OC(C)C)c2)n1)OCC CHEMBL5072532 EC50 29.0 nM
Cn1ccc(Nc2ncnc3ccc(Oc4c(F)cccc4F)cc23)n1 CHEMBL575087 EC50 30.0 nM
CCn1ccc(Nc2ncnc3ccc(Oc4c(F)cccc4S(C)(=O)=O)cc23)n1 CHEMBL578638 EC50 30.0 nM
COC[C@H](C)Oc1cc(O[C@@H](C)Cc2ccccc2)cc(C(=O)Nc2ccc(C(=O)O)cn2)c1 CHEMBL205627 EC50 30.0 nM
COC[C@H](C)Oc1cc(O[C@@H](C)Cc2ccc(Cl)o2)cc(C(=O)Nc2ccc(C(=O)O)cn2)c1 CHEMBL1778357 EC50 30.0 nM
COC[C@H](C)Oc1cc(OCC(F)(F)c2ccccc2)cc(C(=O)Nc2ccc(C(=O)O)cn2)c1 CHEMBL1778362 EC50 30.0 nM
COC[C@H](C)Oc1cc(C#Cc2ccc3c(c2)OCO3)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL3577721 EC50 30.0 nM
COCC(C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(C(=O)Nc2nc3c(s2)CCCC3)c1 CHEMBL4205489 EC50 30.0 nM
CCn1ccc(NC(=O)c2cc(Oc3ccc(C(=O)N4CCC4)cc3)cc(O[C@@H](C)CO)c2)n1 CHEMBL3219105 EC50 31.0 nM
O=C(Nc1ncc(Cl)s1)[C@H](CC1CCOCC1)n1ncc2c(S(=O)(=O)C3CC3)cccc21 CHEMBL4101417 EC50 31.0 nM
C[C@@H](CO)Oc1cc(Oc2ccc(C(=O)N3CCC3)cc2)cc(C(=O)Nc2nccs2)c1 CHEMBL3219108 EC50 32.0 nM
Cc1csc(Nc2ncc(Sc3ccncc3)cc2Oc2ccccc2)n1 CHEMBL4635059 EC50 32.0 nM
CCOP(=O)(Cn1ccc(NC(=O)c2cc(Oc3ccc(S(=O)(=O)C(C)C)cc3)cc(OC(C)C)c2)n1)OCC CHEMBL5092846 EC50 32.0 nM
COC(CNCc1csc(NC(=O)c2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(-c3ncccc3C)c2)n1)OC CHEMBL3235156 EC50 33.0 nM
Nc1ccc(S(=O)(=O)N2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)cc3C#CC3CC3)CC2)cn1 CHEMBL3319527 IC50 33.0 nM
Nc1ccc(S(=O)(=O)N2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)cc3-c3ccc4c(c3)CC(=O)N4)CC2)cn1 CHEMBL3319561 IC50 33.0 nM
Cc1ncccc1Oc1cc(Sc2ccccn2)cnc1Nc1nc(C2CCN(S(C)(=O)=O)CC2)ns1 CHEMBL4639192 EC50 33.0 nM
COC[C@H](C)Oc1cc(C#Cc2ccc(N)cc2)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL3577722 EC50 34.0 nM
O=C(O)c1ccc(Oc2cnc(NC(=O)[C@H](Oc3ccc(F)cc3F)c3ccc(S(=O)(=O)C4CC4)cc3)s2)cc1 CHEMBL5267943 EC50 34.0 nM
CCCN(CCC)S(=O)(=O)c1ccc(C(CC2CCCC2)C(=O)Nc2nc3ccc(OC)nc3s2)cc1 CHEMBL573292 Activity 35.0 nM
Cc1nsc(NC(=O)c2cc(Oc3ccc(C(=O)N4CCC4)cc3)cc(O[C@@H](C)CO)c2)n1 CHEMBL3219109 EC50 35.0 nM
Nc1ccc(S(=O)(=O)N2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)cc3-c3ccc4scnc4c3)CC2)cn1 CHEMBL3319557 IC50 35.0 nM
COC[C@H](C)Oc1cc(Oc2ccc(C(=O)N3CCC3)nc2)cc(C(=O)Nc2cnc(C)cn2)c1 CHEMBL3219121 EC50 36.0 nM
CNC(=O)Nc1cc(Oc2c(F)cccc2F)c(-c2ccc(OC)nc2)cn1 CHEMBL4518905 EC50 36.0 nM
O=C(CO)N1CCC(c2nsc(Nc3ncc(Sc4ccccn4)cc3Oc3ccccc3)n2)CC1 CHEMBL4643638 EC50 36.0 nM
CN1C(=O)CCC1c1cc2[nH]c(-c3ccc(C(F)(F)F)cn3)cc2cc1Oc1ccc(CCC(=O)O)cc1 CHEMBL3970863 EC50 36.4 nM
COC[C@H](C)Oc1cc(Oc2ccc(C(=O)N3CCC3)cc2)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL3219115 EC50 37.0 nM
COC[C@H](C)Oc1cc(C#Cc2cccc(N(C)C)c2)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL3577725 EC50 37.0 nM
CNC(=O)Nc1cc(Oc2cncc(C)c2)c(CCCCO)cn1 CHEMBL4529355 EC50 37.0 nM
C[C@H](O)C(=O)N1CCC(c2nsc(Nc3ncc(Sc4ccccn4)cc3Oc3ccccc3)n2)CC1 CHEMBL4635073 EC50 37.0 nM
O=C(Nc1nccs1)c1nc(Sc2nnc[nH]2)ccc1Sc1ccccc1 CHEMBL551648 EC50 38.0 nM
CNC(=O)Nc1cc(Oc2c(F)cccc2F)c(C2CC2)cn1 CHEMBL4561645 EC50 38.0 nM
CCOP(=O)(Cc1csc(NC(=O)c2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(O[C@@H](C)COC)c2)n1)OCC CHEMBL5091943 EC50 38.0 nM
COc1ccc2nc(NC(=O)C(CC3CCCC3)c3ccc(S(=O)(=O)N4CCN(C)CC4)cc3)sc2n1 CHEMBL573983 Activity 39.0 nM
COC[C@H](C)Oc1cc(C#Cc2cccc(O)c2)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL3577724 EC50 39.0 nM
COCCNc1cccc(C#Cc2cc(O[C@@H](C)COC)cc(C(=O)Nc3ccn(C)n3)c2)c1 CHEMBL3577731 EC50 39.0 nM
CN1C(=O)CCC1c1cc2[nH]c(-c3cnccn3)cc2cc1Oc1ccc(CCC(=O)O)cc1 CHEMBL3965916 EC50 39.1 nM
O=C(Nc1nccs1)c1nc(Sc2nnc[nH]2)ccc1Sc1cccc(F)c1 CHEMBL558885 EC50 40.0 nM
Cn1ccc(Nc2ncnc3ccc(Oc4c(F)cccc4S(C)(=O)=O)cc23)n1 CHEMBL575298 EC50 40.0 nM
Cn1ccc(Nc2ncnc3ccc(Oc4ncccc4F)cc23)n1 CHEMBL572842 EC50 40.0 nM
Cn1ccc(Nc2ncnc3ccc(Oc4ncccc4Cl)cc23)n1 CHEMBL573064 EC50 40.0 nM
CS(=O)(=O)c1cccc(F)c1Oc1ccc2ncnc(Nc3cc[nH]n3)c2c1 CHEMBL575088 EC50 40.0 nM
Cc1nsc(Nc2ncnc3ccc(Oc4c(F)cccc4S(C)(=O)=O)cc23)n1 CHEMBL575904 EC50 40.0 nM
Cc1cnc(Nc2ncnc3ccc(Oc4c(F)cccc4S(C)(=O)=O)cc23)cn1 CHEMBL575918 EC50 40.0 nM
CCS(=O)(=O)c1ccc(Oc2cc3nc(-c4ccccn4)[nH]c3cc2CN2C(=O)CCC2=O)cc1 CHEMBL595122 EC50 40.0 nM
COC[C@H](C)Oc1cc(O[C@@H](C)Cc2ccc(F)cc2)cc(C(=O)Nc2ccc(C(=O)O)cn2)c1 CHEMBL1778354 EC50 40.0 nM
COC[C@H](C)Oc1cc(Oc2cccc(OC)c2)cc(C(=O)Nc2ccc(C(=O)O)cn2)c1 CHEMBL1778366 EC50 40.0 nM
C[C@@H](CO)Oc1cc(Oc2ccc(C(=O)N(C)C)cc2)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL3217924 EC50 40.0 nM
Cc1ccc(-c2cc(C(O)(C(F)(F)F)C(F)(F)F)cnc2N2CCN(S(=O)(=O)c3ccc(N)nc3)CC2)cn1 CHEMBL3319553 IC50 40.0 nM
Cc1c(-c2cc(C(O)(C(F)(F)F)C(F)(F)F)cnc2N2CCN(S(=O)(=O)c3ccc(N)nc3)CC2)cnn1C CHEMBL3319537 IC50 40.0 nM
O=C(Nc1ncc(F)s1)[C@H](CC1CCOCC1)n1ncc2c(S(=O)(=O)C3CC3)cccc21 CHEMBL4083428 EC50 40.0 nM
CNC(=O)Nc1cc(Oc2cncc(C)c2)c([C@H]2C[C@@H](CO)C2)cn1 CHEMBL4529989 EC50 40.0 nM
CCc1cncc(Oc2cc(NC(=O)NC)ncc2-c2ccc(OCCO)nc2)c1 CHEMBL4573996 EC50 40.0 nM
O=C(Nc1ncc(Cl)s1)/C(=N/N1CCCC1)c1ccc(S(=O)(=O)C2CC2)cc1 CHEMBL4641678 EC50 41.0 nM
CCN(CC)S(=O)(=O)c1ccc(C(CC2CCCC2)C(=O)Nc2nc3ccc(OC)nc3s2)cc1 CHEMBL572590 Activity 42.0 nM
CS(=O)(=O)c1ccc(-c2cc(C(O)(C(F)(F)F)C(F)(F)F)cnc2N2CCN(S(=O)(=O)c3ccc(N)nc3)CC2)cc1 CHEMBL3319547 IC50 42.0 nM
CC(=O)N1CCC(c2nsc(Nc3ncc(Sc4ccccn4)cc3Oc3cccnc3C)n2)CC1 CHEMBL4644628 EC50 42.0 nM
CC(O)(c1ccc(N2CCN(S(=O)(=O)c3cccs3)C[C@@H]2CN2[C@H]3COC[C@H]2[C@H](O)C3)cc1)C(F)(F)F CHEMBL3113986 IC50 44.0 nM
CC(C)=CCOc1cc(Oc2ccc(S(=O)(=O)N3CC[C@H](F)C3)cc2)cc(C(=O)Nc2ncc(F)s2)c1 CHEMBL2023054 EC50 44.8 nM
CC(C)=CCOc1cc(Oc2ccc(S(=O)(=O)N3C[C@@H](C)O[C@@H](C)C3)cc2)cc(C(=O)Nc2cc(C)n(C)n2)c1 CHEMBL2023432 EC50 44.8 nM
CNC(=O)Nc1cc(Oc2cncc(C)c2)c(-c2ccc(OC[C@H](C)O)nc2)cn1 CHEMBL4531223 EC50 45.0 nM
CNC(=O)Nc1cc(Oc2c(F)cccc2F)c(-c2ccncc2)cn1 CHEMBL4551474 EC50 45.0 nM
COC[C@H](C)Oc1cc(C#Cc2cccc(OCC#N)c2)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL3577734 EC50 46.0 nM
Cn1ccc(NC(=O)c2cc(Oc3ccc(C(=O)N4CCC4)cc3)cc(OC(CF)CF)c2)n1 CHEMBL3219119 EC50 47.0 nM
Nc1ccc(S(=O)(=O)N2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)cc3-c3ccc4sccc4c3)CC2)cn1 CHEMBL3319556 IC50 47.0 nM
CNC(=O)Nc1cc(Oc2cncc(OC)c2)c(-c2ccc(OCCO)nc2)cn1 CHEMBL4469570 EC50 47.0 nM
c1ccc(CCc2csc(Nc3ncc(Sc4ccncc4)cc3Oc3ccccc3)n2)cc1 CHEMBL4645667 EC50 47.0 nM
CN1C(=O)CCC1c1cc2[nH]c(-c3nc(CC(=O)O)c(Cl)s3)cc2cc1Oc1ccc(S(C)(=O)=O)cc1 CHEMBL3983869 EC50 47.4 nM
CC(C)=CCOc1cc(Oc2ccc(S(=O)(=O)C3CC3)cc2)cc(C(=O)Nc2ncc(F)s2)c1 CHEMBL2022799 EC50 47.7 nM
CC(C)=CCOc1cc(Oc2ccc(S(=O)(=O)N3CCOCC3)cc2)cc(C(=O)Nc2nccs2)c1 CHEMBL2022800 EC50 48.0 nM
Nc1ccc(S(=O)(=O)N2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)cc3-c3cc4ccccc4s3)CC2)cn1 CHEMBL3319565 IC50 48.0 nM
CCOP(=O)(Cn1ccc(NC(=O)c2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(OC(C)C)c2)n1)OCC CHEMBL5093978 EC50 48.0 nM
O=C(Nc1ccc(F)cn1)[C@H](CN1CC(O)C1)Oc1ncnc2c1cnn2-c1c(Cl)cccc1Cl CHEMBL3221523 EC50 49.0 nM
CC(C)(O)C#Cc1cc(C(O)(C(F)(F)F)C(F)(F)F)cnc1N1CCN(S(=O)(=O)c2ccc(N)nc2)CC1 CHEMBL3319530 IC50 49.0 nM
COc1ccc(Sc2ccc(Sc3ccccn3)nc2C(=O)Nc2nc(CC(=O)O)cs2)cc1 CHEMBL4091838 EC50 49.0 nM
CC(=O)N1CCC(c2nsc(Nc3ncc(Sc4ccccn4)cc3Oc3ccccc3)n2)CC1 CHEMBL4638110 EC50 49.0 nM
CCOP(=O)(Cn1ncc(NC(=O)c2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(O[C@@H](C)COC)c2)n1)OCC CHEMBL5083525 EC50 49.0 nM
CN1C(=O)CCC1c1cc2[nH]c(-c3nc(CC(=O)O)c(Cl)s3)cc2cc1Oc1ccc(S(C)(=O)=O)nc1 CHEMBL3982875 EC50 49.1 nM
C[C@@H](CO)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(C(=O)Nc2nccs2)c1 CHEMBL561652 EC50 50.0 nM
CS(=O)(=O)c1ccc(Oc2cc(O[C@H]3CCOC3)cc(C(=O)Nc3nccs3)c2)cc1 CHEMBL564270 EC50 50.0 nM
Cc1csc(Nc2ncnc3ccc(Oc4ccccc4F)cc23)n1 CHEMBL573750 EC50 50.0 nM
COc1ccc2nc(NC(=O)C(CC3CCCC3)c3ccc(S(=O)(=O)N4CCNCC4)cc3)sc2n1 CHEMBL1204008 Activity 50.0 nM
COC[C@H](C)Oc1cc(O[C@@H](C)Cc2cc(F)cc(F)c2)cc(C(=O)Nc2ccc(C(=O)O)cn2)c1 CHEMBL1778356 EC50 50.0 nM
COC[C@H](C)Oc1cc(Oc2ccc(C(=O)N(C)C)cc2)cc(C(=O)Nc2cc[nH]n2)c1 CHEMBL3217758 EC50 50.0 nM
NC(=O)c1cccc(-c2cc(C(O)(C(F)(F)F)C(F)(F)F)cnc2N2CCN(S(=O)(=O)c3ccc(N)nc3)CC2)c1 CHEMBL3319546 IC50 50.0 nM
COC[C@H](C)Oc1cc(Oc2ccc(C(=O)N3CCC3)cc2)cc(C(=O)Nc2nc3c(s2)CN(C(=O)OC(C)(C)C)CC3)c1 CHEMBL4203455 EC50 50.0 nM
CNC(=O)Nc1cc(Oc2cncc(C)c2)c(-c2ccc(OCCO)nc2)cn1 CHEMBL4446305 EC50 50.0 nM
CNC(=O)Nc1cc(Oc2c(F)cccc2F)c(-c2ccccc2)cn1 CHEMBL4436344 EC50 50.0 nM
COCC[C@H](Oc1ncnc2c1cnn2-c1ccccc1Cl)C(=O)Nc1ccc(C)cn1 CHEMBL2206790 pEC50 50.12 nM
O=C(Nc1ccc(F)cn1)[C@H](CN1CC(O)C1)Oc1ncnc2c1cnn2-c1c(F)cccc1Cl CHEMBL3221529 pEC50 50.12 nM
CNC(=O)Nc1cc(Oc2cncc(C)c2)c([C@H]2C[C@@H](C(C)(C)O)C2)cn1 CHEMBL4592014 EC50 51.0 nM
CN1C(=O)CCC1c1cc2[nH]c(-c3ccc(CCC(=O)O)cn3)cc2cc1Oc1ccc(S(C)(=O)=O)cc1 CHEMBL3966487 EC50 51.5 nM
COc1ccc(Sc2ccc(Sc3nncn3C)nc2C(=O)Nc2ncc(SCC(=O)O)s2)cc1 CHEMBL4062363 EC50 51.5 nM
CC(C)=CCOc1cc(Oc2ccc(S(=O)(=O)N3CCOCC3)cc2)cc(C(=O)Nc2ncc(F)s2)c1 CHEMBL2022801 EC50 52.0 nM
CC(C)=CCOc1cc(Oc2ccc(S(=O)(=O)N3CC[C@H](F)C3)cc2)cc(C(=O)Nc2nccs2)c1 CHEMBL2023053 EC50 52.3 nM
C[C@@H](CO)Oc1cc(Oc2ccc(C(=O)N3CCC3)cc2)cc(C(=O)Nc2cc[nH]n2)c1 CHEMBL3219107 EC50 53.0 nM
COC[C@H](C)Oc1cc(C#Cc2cccc(OC(C)C)c2)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL3577733 EC50 53.0 nM
CCS(=O)(=O)c1ccc(Oc2cc3cc(-c4ccc(CCC(=O)O)cn4)[nH]c3cc2C2CCC(=O)N2C)cc1 CHEMBL3890812 EC50 53.4 nM
CCS(=O)(=O)c1ccc(Oc2cc3cc(-c4ccc(P(C)(=O)O)cn4)[nH]c3cc2C2CCC(=O)N2C)cc1 CHEMBL3972850 EC50 53.6 nM
COC[C@H](C)Oc1cc(/C=C/c2ccccc2F)cc(C(=O)Nc2ccc(C(=O)O)cn2)c1 CHEMBL2315021 EC50 56.0 nM
CCC#CC1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1 CHEMBL3114188 IC50 56.0 nM
C[C@](O)(c1ccc(N2CCN(S(=O)(=O)c3cccs3)C[C@@H]2CN2[C@@H]3COC[C@H]2[C@@H](O)C3)cc1)C(F)(F)F CHEMBL3113991 IC50 56.0 nM
O=C(Nc1nccs1)c1nc(Sc2nnc[nH]2)ccc1Sc1ccccc1F CHEMBL551558 EC50 57.0 nM
CC(C)c1csc(Nc2ncc(Sc3ccncc3)cc2Oc2ccccc2)n1 CHEMBL4643142 EC50 58.0 nM
CC[C@@H](COC)Oc1cc(Oc2ccc(S(=O)(=O)OC)cc2)cc(C(=O)Nc2nccs2)c1 CHEMBL2021545 EC50 60.0 nM
CC(CCO)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(C(=O)Nc2nccs2)c1 CHEMBL551977 EC50 60.0 nM
CCC(COC)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(C(=O)Nc2nccs2)c1 CHEMBL562878 EC50 60.0 nM
CC(C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(C(=O)Nc2nccs2)c1 CHEMBL550904 EC50 60.0 nM
Cn1ccc(Nc2ncnc3ccc(Oc4ccc(F)cc4F)cc23)n1 CHEMBL584807 EC50 60.0 nM
CCS(=O)(=O)c1ccc(Oc2cc3nc(-c4ccccn4)[nH]c3cc2CN2CCCC2=O)cc1 CHEMBL604065 EC50 60.0 nM
CCS(=O)(=O)c1ccc(Oc2cc3nc(-c4ccccn4)[nH]c3cc2CN2CCOC2=O)cc1 CHEMBL595362 EC50 60.0 nM
CCS(=O)(=O)c1ccc(Oc2cc3nc(-c4ccccn4)[nH]c3cc2CN2C(=O)CN(C)C2=O)cc1 CHEMBL596032 EC50 60.0 nM
COC[C@H](C)Oc1cc(Oc2ccc(OC)cc2)cc(C(=O)Nc2ccc(C(=O)O)cn2)c1 CHEMBL1778367 EC50 60.0 nM
COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(C(=O)Nc2ccc(C(=O)O)cn2)c1 CHEMBL1778372 EC50 60.0 nM
Cc1ccc(NC(=O)[C@H](CC2CCCC2)n2ccc(S(=O)(=O)C3CCC3)cc2=O)nc1 CHEMBL1783740 EC50 60.0 nM
COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(C(=O)Nc2nccs2)c1 CHEMBL3217922 EC50 60.0 nM
COC[C@H](C)Oc1cc(Oc2ncc(C(=O)N3CCC3)cc2Cl)cc(C(=O)Nc2cnc(C)cn2)c1 CHEMBL3219123 EC50 60.0 nM
Nc1ccc(S(=O)(=O)N2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)cc3-c3ccc4[nH]ncc4c3)CC2)cn1 CHEMBL3319562 IC50 60.0 nM
CNC(=O)Nc1cc(Oc2cncc(C)c2)c(-c2ccc(OCC(C)(C)O)nc2)cn1 CHEMBL4454070 EC50 60.0 nM
CNC(=O)Nc1cc(Oc2cncc(C)c2)c(-c2ccc(OC[C@@H](C)O)nc2)cn1 CHEMBL4581836 EC50 60.0 nM
COCCNS(=O)(=O)c1ccc(C(CC2CCCC2)C(=O)Nc2nc3ccc(OC)nc3s2)cc1 CHEMBL574131 Activity 61.0 nM
O=C(Nc1nc2c(s1)CCCC2)C(CC1CCOCC1)c1ccc(S(=O)(=O)C2CC2)cc1 CHEMBL1165284 EC50 61.0 nM
Cc1cnc(NC(=O)c2cc(Oc3ccc(C(=O)N4CCC4)cc3)cc(O[C@@H](C)CO)c2)cn1 CHEMBL3219110 EC50 61.0 nM
CCOP(=O)(Cn1ccc(NC(=O)c2cc(Oc3cnc(C(=O)N4CCC4)nc3)cc(OC(C)C)c2)n1)OCC CHEMBL5094606 EC50 61.0 nM
CC(C)=CCOc1cc(Oc2ccc(S(=O)(=O)N3C[C@@H](C)O[C@@H](C)C3)cc2)cc(C(=O)Nc2nccs2)c1 CHEMBL2022802 EC50 62.6 nM
O=C(Nc1nccs1)[C@H](CC1CCCCC1)N1CCN(S(=O)(=O)C2CCCC2)CC1=O CHEMBL2346882 EC50 63.0 nM
CC(C)=CCOc1cc(Oc2ccc(S(=O)(=O)N3CC[C@H](F)C3)cc2)cc(C(=O)Nc2cc(C)n(C)n2)c1 CHEMBL2023436 EC50 63.1 nM
COCC[C@H](Oc1ncnc2c1cnn2-c1ccccc1C(F)(F)F)C(=O)Nc1ccc(C)cn1 CHEMBL2206791 pEC50 63.1 nM
O=C(Nc1ccc(Cl)cn1)[C@H](CN1CC(O)C1)Oc1ncnc2c1cnn2-c1ccccc1Cl CHEMBL3221517 pEC50 63.1 nM
CN1C(=O)CCC1c1cc2[nH]c(-c3ccc(C(F)(F)F)cn3)cc2cc1Oc1ccc(CC(=O)O)cc1 CHEMBL3894527 EC50 63.9 nM
Cc1cnc(NC(=O)c2cc(Oc3cnc(C(=O)N4CCCC4)cn3)c3cc(C)oc3c2)cn1 CHEMBL3218488 EC50 64.0 nM
O=C(Nc1ncc(Oc2cccc(CO)c2)s1)C(OC1CCOCC1)c1ccc(S(=O)(=O)C2CC2)cc1 CHEMBL3890502 EC50 64.0 nM
COC1CCN(S(=O)(=O)c2ccc(Oc3cc(OCC=C(C)C)cc(C(=O)Nc4ncc(F)s4)c3)cc2)CC1 CHEMBL2023056 EC50 64.6 nM
COC(=O)Cc1csc(-c2cc3cc(Oc4ccc(S(C)(=O)=O)cc4)c(C4CCC(=O)N4C)cc3[nH]2)n1 CHEMBL3955232 EC50 65.1 nM
CC(C)=CCOc1cc(Oc2ccc(S(=O)(=O)N3C[C@@H](C)O[C@@H](C)C3)cc2)cc(C(=O)Nc2ncc(F)s2)c1 CHEMBL2023050 EC50 65.4 nM
COc1ccc2nc(NC(=O)C(CC3CCCC3)c3ccc(S(=O)(=O)N(C)Cc4nccn4C)cc3)sc2n1 CHEMBL575096 Activity 66.0 nM
COc1ccc2nc(NC(=O)C(CC3CCCC3)c3ccc(S(=O)(=O)N4CCCCC4)cc3)sc2n1 CHEMBL576925 Activity 66.0 nM
Cc1csc(NC(=O)c2cc(Sc3nccn3C)c(F)cc2N)n1 CHEMBL1783735 EC50 66.0 nM
CNC(=O)Nc1cc(Oc2cncc(OC)c2)c(C2=CCOCC2)cn1 CHEMBL4451652 EC50 66.0 nM
CNC(=O)Nc1cc(Oc2cncc(C)c2)c(CCCO)cn1 CHEMBL4516141 EC50 66.0 nM
CN1C(=O)CCC1c1cc2[nH]c(-c3ncc(CCC(=O)O)s3)cc2cc1Oc1ccc(S(C)(=O)=O)cc1 CHEMBL3905981 EC50 66.7 nM
CCOP(=O)(Cn1ccc(NC(=O)c2cc(Oc3ccc(S(=O)(=O)N4CCC4)cc3)cc(OC(C)C)c2)n1)OCC CHEMBL5072442 EC50 67.0 nM
Cn1ccnc1Sc1cc(C(=O)Nc2nccs2)c(N)cc1F CHEMBL608393 EC50 67.11 nM
CCn1nccc1Oc1cc(C[C@H]2CC[C@H](O)CC2)cnc1NC(=O)NC CHEMBL3358442 EC50 68.0 nM
COc1ccc(Sc2ccc(Sc3ccccn3)nc2C(=O)Nc2ncc(CCC(=O)O)s2)cc1 CHEMBL4070998 EC50 68.5 nM
CN1C(=O)CCC1c1cc2[nH]c(-c3ncc(CCC(=O)O)s3)cc2cc1Oc1ccc(S(C)(=O)=O)nc1 CHEMBL3911909 EC50 68.8 nM
C[C@@H](O)C(=O)N1CCC(c2nsc(Nc3ncc(Sc4ccccn4)cc3Oc3ccccc3)n2)CC1 CHEMBL4636593 EC50 69.0 nM
O=C(Nc1ncc(F)s1)[C@H](CC1CCOCC1)c1ccc(S(=O)(=O)C2CCCC2)cc1 CHEMBL480725 EC50 70.0 nM
CC(CO)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(C(=O)Nc2nccs2)c1 CHEMBL551183 EC50 70.0 nM
COCC(C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(C(=O)Nc2nccs2)c1 CHEMBL562311 EC50 70.0 nM
CS(=O)(=O)c1cccc(F)c1Oc1ccc2ncnc(Nc3cnccn3)c2c1 CHEMBL576936 EC50 70.0 nM
CCS(=O)(=O)c1ccc(Oc2cc3nc(-c4ccccn4)[nH]c3cc2CN(C)C(C)=O)cc1 CHEMBL596480 EC50 70.0 nM
CCS(=O)(=O)c1ccc(Oc2cc3nc(-c4ccccn4)[nH]c3cc2Cc2nnnn2C)cc1 CHEMBL595353 EC50 70.0 nM
COC[C@H](C)Oc1cc(O[C@@H](C)Cc2ccccc2OC)cc(C(=O)Nc2ccc(C(=O)O)cn2)c1 CHEMBL1778355 EC50 70.0 nM
COC[C@H](C)Oc1cc(OC[C@H](C)c2ccccc2)cc(C(=O)Nc2ccc(C(=O)O)cn2)c1 CHEMBL1778361 EC50 70.0 nM
Cc1ccc(NC(=O)[C@H](CC2CCCC2)n2ccc(S(=O)(=O)C(C)C)c(Cl)c2=O)nc1 CHEMBL1783745 EC50 70.0 nM
COC[C@H](C)Oc1cc(CCc2c(F)cccc2F)cc(C(=O)Nc2ccc(C(=O)O)cn2)c1 CHEMBL2311574 EC50 70.0 nM
CCc1cnc(-c2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(OC(C)C)c2)[nH]c1=O CHEMBL2408112 EC50 70.0 nM
COC[C@H](C)Oc1cc(Oc2cc(F)cc(F)c2)cc(C(=O)Nc2nccs2)c1 CHEMBL3217921 EC50 70.0 nM
Cn1ccc(NC(=O)c2cc(Oc3ccc(C(=O)N4CCC4)cc3)cc(O[C@H]3CCOC3)c2)n1 CHEMBL3219117 EC50 70.0 nM
CS(=O)(=O)N1CCC(c2nsc(Nc3ncc(Sc4ccccn4)cc3Oc3ccccc3)n2)CC1 CHEMBL4641920 EC50 70.0 nM
COCc1ccc(Oc2cc3cc(-c4ccc(CCC(=O)O)cn4)[nH]c3cc2C2CCC(=O)N2C)cn1 CHEMBL3971117 EC50 71.8 nM
CNC(=O)Nc1cc(Oc2cncc(C)c2)c([C@H]2CCC[C@H](O)C2)cn1 CHEMBL4554222 EC50 72.0 nM
CNC(=O)Nc1cc(Oc2cncc(C)c2)c([C@H]2C[C@H](O)C2)cn1 CHEMBL4469251 EC50 72.0 nM
Cc1csc(Nc2ncc(Sc3ccccn3)cc2Oc2ccccc2)n1 CHEMBL4642217 EC50 72.0 nM
COc1ccc2nc(NC(=O)C(CC3CCCC3)c3ccc(S(=O)(=O)N(C(C)C)C(C)C)cc3)sc2n1 CHEMBL577191 Activity 73.0 nM
CC(C)n1ccc(NC(=O)c2cc(Oc3ccc(C(=O)N4CCC4)cc3)cc(O[C@@H](C)CO)c2)n1 CHEMBL3219106 EC50 73.0 nM
COC[C@H](C)Oc1cc(Oc2ccc(C(=O)N3CCC3)cc2)cc(C(=O)Nc2cnc(C)cn2)c1 CHEMBL3219120 EC50 73.0 nM
CCOP(=O)(Cn1ccc(NC(=O)c2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(O[C@@H](C)COC)c2)n1)OCC CHEMBL5071861 EC50 75.0 nM
O=C(Nc1nccs1)c1nc(Sc2nnc[nH]2)ccc1Sc1ccc(F)cc1 CHEMBL563986 EC50 76.0 nM
CCOP(=O)(Cn1ccc(NC(=O)c2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(OC(CF)CF)c2)n1)OCC CHEMBL5081517 EC50 76.0 nM
Cc1csc(Nc2ncc(SCc3ccccn3)cc2OCc2ccccc2)n1 CHEMBL2430860 EC50 77.0 nM
CC(C)=CCOc1cc(Oc2ccc(S(=O)(=O)N3CC4CCC(C3)O4)cc2)cc(C(=O)Nc2ncc(F)s2)c1 CHEMBL2023052 EC50 78.0 nM
O=C(Nc1ccc(F)cn1)[C@H](CN1CC(O)C1)Oc1ncnc2c1cnn2-c1ccccc1Cl CHEMBL3221520 EC50 78.0 nM
Cc1cnc(NC(=O)[C@H](CO[C@H](C)CO)Oc2ncnc3c2cnn3-c2c(Cl)cccc2C#N)cn1 CHEMBL3221532 EC50 78.0 nM
Cc1nsc(Nc2ncc(Sc3ccccn3)cc2Oc2ccccc2)n1 CHEMBL4642812 EC50 78.0 nM
O=C(Nc1nc2c(s1)CCC2)C(CC1CCOCC1)c1ccc(S(=O)(=O)C2CC2)cc1 CHEMBL1164790 EC50 79.0 nM
Cc1cc(S(=O)(=O)C2CCCC2)cc(=O)n1[C@@H](CC1CCCCC1)C(=O)Nc1nccs1 CHEMBL2346761 EC50 79.0 nM
CNC(=O)c1ccc2c(=O)n([C@@H](CC3CCCCC3)C(=O)Nc3ncc(Cl)s3)cnc2c1 CHEMBL2346891 EC50 79.0 nM
CCOP(=O)(Cn1ccc(NC(=O)c2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(O[C@@H](C)CO)c2)n1)OCC CHEMBL5088988 EC50 79.0 nM
Cc1cnc(NC(=O)[C@H](COC2CCC2)Oc2ncnc3c2cnn3-c2ccccc2Cl)cn1 CHEMBL3221491 pEC50 79.43 nM
O=C(Nc1ccccn1)[C@H](CN1CC(O)C1)Oc1ncnc2c1cnn2-c1c(F)cccc1Cl CHEMBL3221528 pEC50 79.43 nM
Cc1csc(Nc2ncnc3ccc(Oc4ccccc4S(C)(=O)=O)cc23)n1 CHEMBL573749 EC50 80.0 nM
Cn1ccc(Nc2ncnc3ccc(Oc4ccccc4S(C)(=O)=O)cc23)n1 CHEMBL575067 EC50 80.0 nM
Cn1ccc(Nc2ncnc3ccc(Oc4c(Cl)cccc4S(C)(=O)=O)cc23)n1 CHEMBL574884 EC50 80.0 nM
CCS(=O)(=O)c1ccc(Oc2cc3nc(-c4ccccn4)[nH]c3cc2CN2CCN(C)C2=O)cc1 CHEMBL594633 EC50 80.0 nM
COC[C@H](C)Oc1cc(/C=C/c2ccccc2F)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL2314797 EC50 80.0 nM
O=C(Nc1ncc(F)s1)[C@H](CC1CCOCC1)n1ncc2c(S(=O)(=O)C3CC3)cncc21 CHEMBL4083023 EC50 80.0 nM
CN1C(=O)CCC1c1cc2[nH]c(-c3ccc(OCC(=O)O)cn3)cc2cc1Oc1ccc(S(C)(=O)=O)nc1 CHEMBL3903467 EC50 81.0 nM
COC[C@H](C)Oc1cc(/C=C/c2ccccc2OC)cc(C(=O)Nc2ccc(C(=O)O)cn2)c1 CHEMBL2315027 EC50 83.0 nM
CNC(=O)Nc1cc(Oc2cncc(C)c2)c([C@H]2C[C@@H]2C(C)(C)O)cn1 CHEMBL4592224 EC50 83.0 nM
CC(C)=CCOc1cc(Oc2ccc(S(=O)(=O)N3CC[C@H](F)C3)cc2)cc(C(=O)Nc2ccn(C)n2)c1 CHEMBL2023437 EC50 83.5 nM
Cc1cnc(NC(=O)c2cc(Oc3cnc(C(=O)N4CCC4)cn3)c3cc(C)oc3c2)cn1 CHEMBL3218487 EC50 85.0 nM
CN(C)C(=O)c1cnc(Oc2cc(C(=O)Nc3ccn(C)n3)cc3c2CC(C)(CO)O3)cn1 CHEMBL3580739 Kd 86.4 nM
Nc1ccc(S(=O)(=O)N2CCN(c3ccc(C(O)(C(F)(F)F)C(F)(F)F)cc3)CC2)cn1 CHEMBL3114000 IC50 87.0 nM
CC(C)(C)n1cc(-c2cc(C(O)(C(F)(F)F)C(F)(F)F)cnc2N2CCN(S(=O)(=O)c3ccc(N)nc3)CC2)cn1 CHEMBL3319536 IC50 87.0 nM
Cc1cc(Oc2cnc(NC(=O)C(OC3CCOCC3)c3ccc(S(=O)(=O)C4CC4)cc3)s2)ccc1C(=O)O CHEMBL3941597 EC50 87.0 nM
CCOP(=O)(Cn1ccc(NC(=O)c2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(O[C@@H](C)CF)c2)n1)OCC CHEMBL5083369 EC50 87.0 nM
COCc1ccc(Oc2cc3[nH]c(-c4ccccn4)nc3cc2[C@H]2CCCN2C(C)=O)cn1 CHEMBL3218478 EC50 88.0 nM
CCc1ncccc1Oc1cc(Sc2ccccn2)cnc1NC(=O)NC CHEMBL3338060 EC50 88.0 nM
CNC(=O)Nc1cc(Oc2c(F)cccc2F)c(-c2ccc(OCCO)nc2)cn1 CHEMBL4528120 EC50 88.0 nM
O=C(Nc1ncc(F)s1)C(CC1CCOCC1)c1ccc(S(=O)(=O)C2CC2)cc1 CHEMBL1164184 EC50 89.0 nM
O=C(O)c1ccc(NC(=O)c2cc(OCc3ccccc3F)cc(OCc3ccccc3F)c2)nc1 CHEMBL373364 EC50 90.0 nM
CC(C)Oc1cc(OCCc2ccsc2)cc(C(=O)Nc2ccc(C(=O)O)cn2)c1 CHEMBL373339 EC50 90.0 nM
CC(C)Oc1cc(O[C@H](C)Cc2ccccc2)cc(C(=O)Nc2ccc(C(=O)O)cn2)c1 CHEMBL439344 EC50 90.0 nM
Cc1csc(NC(=O)c2cc(Oc3cccc(S(C)(=O)=O)c3)cc(OC(C)C)c2)n1 CHEMBL484018 EC50 90.0 nM
CS(=O)(=O)c1ccc(Oc2cc(O[C@H]3CCC[C@@H]3O)cc(C(=O)Nc3nccs3)c2)cc1 CHEMBL564282 EC50 90.0 nM
CCS(=O)(=O)c1ccc(Oc2cc3nc(-c4ccccn4)[nH]c3cc2CN2CCCS2(=O)=O)cc1 CHEMBL596020 EC50 90.0 nM
COC[C@H](C)Oc1cc(O[C@@H](C)CC2CCCC2)cc(C(=O)Nc2ccc(C(=O)O)cn2)c1 CHEMBL1778358 EC50 90.0 nM
COC[C@H](C)Oc1cc(Oc2cc(F)cc(F)c2)cc(C(=O)Nc2ccc(C(=O)O)cn2)c1 CHEMBL1778373 EC50 90.0 nM
O=C(O)c1ccc(NC(=O)[C@H](CC2CCCC2)n2cnc(C(F)(F)F)c2)nc1 CHEMBL2165620 EC50 90.0 nM
COC[C@H](C)Oc1cc(/C=C/c2c(F)cccc2F)cc(C(=O)Nc2ccc(C(=O)O)cn2)c1 CHEMBL2315025 EC50 90.0 nM
Cc1cnc(-c2cc(Oc3ccc(S(=O)(=O)N(C)C)cc3)cc(O[C@@H](C)CO)c2)[nH]c1=O CHEMBL2408129 EC50 90.0 nM
CC1CS(=O)(=O)CCN1C[C@H]1CN(S(=O)(=O)c2cccs2)CCN1c1ccc(C(C)(O)C(F)(F)F)cc1 CHEMBL3113983 IC50 90.0 nM
COCC(C)Oc1cc(Oc2ccc(C(=O)N(C)C)cc2)cc(C(=O)Nc2nc3c(s2)CN(C(=O)OC(C)(C)C)CC3)c1 CHEMBL4206856 EC50 90.0 nM
CC(C)=CCOc1cc(Oc2ccc(S(=O)(=O)C3CC3)cc2)cc(C(=O)Nc2cc(C)n(C)n2)c1 CHEMBL2023060 EC50 90.1 nM
COC1CCN(S(=O)(=O)c2ccc(Oc3cc(OCC=C(C)C)cc(C(=O)Nc4nccs4)c3)cc2)CC1 CHEMBL2023055 EC50 90.4 nM
Cc1cnc(NC(=O)c2cc(Oc3ccc(C(=O)N(C)C)cc3)c3cc(C)oc3c2)cn1 CHEMBL3218482 EC50 92.0 nM
c1ccc(Oc2cc(Sc3ccncc3)cnc2Nc2nc(C3CCCCC3)cs2)cc1 CHEMBL4646132 EC50 92.0 nM
Cc1cc(Oc2cnc(NC(=O)C(Oc3ccc(F)cc3F)c3ccc(S(=O)(=O)C4CC4)cc3)s2)ccc1C(=O)O CHEMBL3908170 EC50 93.0 nM
CC(C)(C(=O)O)c1ccc(Oc2cnc(NC(=O)C(OC3CCOCC3)c3ccc(S(=O)(=O)C4CC4)cc3)s2)cc1 CHEMBL3953779 EC50 94.0 nM
COC[C@H](C)Oc1cc(/C=C/c2ccc(F)cc2F)cc(C(=O)Nc2ccc(C(=O)O)cn2)c1 CHEMBL2315023 EC50 95.0 nM
Cc1cccnc1-c1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(C(=O)Nc2nccs2)c1 CHEMBL3235145 EC50 95.0 nM
CC(C)=CCOc1cc(Oc2ccc(S(=O)(=O)N3CCOCC3)cc2)cc(C(=O)Nc2cc(C)n(C)n2)c1 CHEMBL2023063 EC50 95.1 nM
Cc1cnc(NC(=O)[C@H](CN2CC(O)C2)Oc2ncnc3c2cnn3-c2c(Cl)cccc2Cl)cn1 CHEMBL3221531 EC50 96.0 nM
CCn1nccc1Oc1cc(C[C@H]2CC[C@@](C)(O)CC2)cnc1NC(=O)NC CHEMBL3358445 EC50 97.0 nM
CNC(=O)Nc1cc(Oc2cncc(C)c2)c([C@@H]2CC[C@@H](O)C2)cn1 CHEMBL4471994 EC50 97.0 nM
CCOCCc1cnc(NC(=O)NC)cc1Oc1cncc(C)c1 CHEMBL4522622 EC50 98.0 nM
Cc1csc(Nc2ncc(Sc3ccccc3)cc2Oc2ccccc2)n1 CHEMBL4642648 EC50 98.0 nM
CCOP(=O)(Cn1ccc(NC(=O)c2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(O[C@@H](CC)CO)c2)n1)OCC CHEMBL5093208 EC50 98.0 nM