COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4)cc3)n2-c2ccc(F)cc2)cc1OC CHEMBL3793436 EC50 0.057 nM
O=C1COc2nccc(-c3ccccc3F)c2CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL2181247 EC50 0.23 nM
Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 CHEMBL3290717 EC50 0.28 nM
Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C(C)C CHEMBL2336232 EC50 0.3 nM
Cc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl CHEMBL2181229 EC50 0.31 nM
C[C@H](c1ccccc1)n1cncc1C(=O)N1CCN(C2CC2)c2ccccc21 CHEMBL4779837 EC50 0.33 nM
Cc1noc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 CHEMBL5270816 EC50 0.43 nM
Cc1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 CHEMBL3290716 EC50 0.45 nM
O=C(c1cnccc1Oc1cc(Cl)c(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 CHEMBL2181227 EC50 0.46 nM
Cc1cc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1C CHEMBL2181228 EC50 0.6 nM
CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl CHEMBL2181230 EC50 0.72 nM
Cc1ccc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 CHEMBL2181226 EC50 0.72 nM
COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 CHEMBL4779084 EC50 0.9 nM
COc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)c1 CHEMBL612138 pEC50 1.0 nM
N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCN(C5COC5)CC4)nc(C(F)(F)F)n3)C2)cc1 CHEMBL3234570 EC50 1.0 nM
Cc1cc(/C(C[C@H](c2ccc(C3C[C@@H]4C(C(=O)O)[C@@H]4C3)cc2)c2ccc(F)cc2F)=N\O)ccn1 CHEMBL5290871 EC50 1.0 nM
C[C@H](c1ccccc1)n1cncc1C(=O)N(C)c1ccc(F)cc1 CHEMBL4743463 EC50 1.05 nM
C[C@H](c1ccccc1)n1cncc1C(=O)N1CCN(c2ccccc2F)CC1 CHEMBL4790044 EC50 1.09 nM
Cc1ccc(CN(C(=O)c2c(C)nn(C)c2Oc2cccc(Cl)c2Cl)C(C)C)cn1 CHEMBL2336233 EC50 1.2 nM
CCN(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl CHEMBL2336231 EC50 1.2 nM
O=C(c1cnccc1Oc1cc2ccoc2cc1Cl)N1CCN(C2CC2)c2ccccc21 CHEMBL3290715 EC50 1.4 nM
Fc1cccc(F)c1-c1ccncc1CN1C(c2ccco2)=NO[C@@H]1c1cc(C(F)(F)F)cc(C(F)(F)F)c1Cl CHEMBL5284434 EC50 1.4 nM
COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4C)cc3)n2-c2ccc(F)cc2)cc1OC CHEMBL3794442 EC50 1.48 nM
O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 CHEMBL2181239 EC50 1.5 nM
Cc1noc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 CHEMBL3290713 EC50 1.5 nM
COc1ccccc1COC(=O)C1=C(C)N(C[C@H]2CCCO2)C(=O)C[C@H]1c1ccc(Cl)nc1 CHEMBL5434983 pEC50 1.585 nM
CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(SC(F)(F)F)cc1)CC2 CHEMBL2331649 EC50 1.6 nM
COc1ccc(C(C)(C)c2cnc(SCCOCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC CHEMBL4126062 EC50 1.6 nM
CCOC(=O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 CHEMBL3290720 EC50 1.7 nM
Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cncs1)C(C)C CHEMBL2331604 EC50 1.8 nM
COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(Cl)cc2)c1 CHEMBL3132966 EC50 1.9 nM
CCc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 CHEMBL2331653 EC50 2.0 nM
CN1CCN(c2cc(C(F)(F)F)nc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)n2)CC1 CHEMBL3234565 EC50 2.0 nM
COc1ccccc1COC(=O)C1=C(C)N(CC2CCCO2)C(=O)CC1c1ccc(Cl)nc1 CHEMBL5394911 EC50 2.0 nM
CCc1nnn(-c2cccc(OC)c2)c1C(=O)N(C)c1ccc(Cl)cc1 CHEMBL3132965 EC50 2.1 nM
CCCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 CHEMBL4776876 EC50 2.1 nM
CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 CHEMBL2331648 EC50 2.3 nM
CC(=O)c1cc(C(=O)N2CCN(C3CC3)c3ccccc32)ccc1O CHEMBL3286440 EC50 2.3 nM
COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(C#N)cc3)n2-c2ccc(F)cc2)cc1OC CHEMBL3793012 EC50 2.3 nM
COc1ccc(C(C)(C)c2cnc(SCCOCc3ccc(C#N)cc3)n2-c2ccc(F)cc2)cc1OC CHEMBL4127302 EC50 2.3 nM
CCC(C)N(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl CHEMBL2336234 EC50 2.4 nM
CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 CHEMBL2331646 EC50 2.5 nM
CC1C(=O)N(CC(=O)NCCOCCOCCOCCOCCOCCNC(=O)CCc2cc(Cl)c(Oc3ccsc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL5427760 EC50 2.5 nM
CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)cc1)CC2 CHEMBL2331651 EC50 2.7 nM
O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CCC2)c2ccccc21 CHEMBL2181240 EC50 2.8 nM
NC(=O)c1nc(C2CC2)nc2c1CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 CHEMBL2331655 EC50 2.8 nM
CCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 CHEMBL4791709 EC50 2.8 nM
CC1C(=O)N(CC(=O)NCCOCCOCCOCCOCCOCCOCCNC(=O)CCc2cc(Cl)c(Oc3ccsc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL5414305 EC50 2.8 nM
CC1C(=O)N(CC(=O)NCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCc2cc(Cl)c(Oc3ccsc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL5437749 EC50 2.8 nM
O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 CHEMBL2181256 EC50 2.9 nM
CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 CHEMBL3234568 EC50 3.0 nM
CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 CHEMBL2181235 EC50 3.1 nM
CC1C(=O)N(CC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCc2cc(Cl)c(Oc3ccsc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL5395284 EC50 3.2 nM
CCOc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 CHEMBL2331654 EC50 3.3 nM
CN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 CHEMBL3321845 EC50 3.5 nM
N[C@@H](CC(=O)N1CCCN(CC(=O)NCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCc2cc(Cl)c(Oc3ccsc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)C(=O)C1Cc1ccccc1)Cc1cc(F)c(F)cc1F CHEMBL5394421 EC50 3.6 nM
N[C@@H](CC(=O)N1CCCN(CC(=O)NCCOCCOCCOCCOCCOCCOCCNC(=O)CCc2cc(Cl)c(Oc3ccsc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)C(=O)C1Cc1ccccc1)Cc1cc(F)c(F)cc1F CHEMBL5415272 EC50 3.7 nM
N[C@@H](CC(=O)N1CCCN(CC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCc2cc(Cl)c(Oc3ccsc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)C(=O)C1Cc1ccccc1)Cc1cc(F)c(F)cc1F CHEMBL5422904 EC50 3.8 nM
CN1CCN(C(=O)c2cnc(O)nc2Oc2cc(Cl)ccc2Cl)c2ccccc21 CHEMBL3321846 EC50 3.9 nM
CCc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 CHEMBL603112 pEC50 3.981 nM
CN(C(=O)c1c(-c2ccccc2Cl)noc1C1CC1)c1ccc(Cl)cc1 CHEMBL601638 pEC50 3.981 nM
Cc1cc(/C(C[C@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 CHEMBL2407930 EC50 4.0 nM
CN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 CHEMBL3234577 EC50 4.0 nM
Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)nc(N2CCN(C)CC2)c1F CHEMBL3234566 EC50 4.0 nM
COc1ccc(N2CCN(C(=O)c3cncn3[C@H](C)c3ccccc3)CC2)cc1 CHEMBL4759282 EC50 4.39 nM
CC1C(=O)N(CC(=O)NCCOCCOCCOCCNC(=O)CCc2cc(Cl)c(Oc3ccsc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL5432337 EC50 4.5 nM
CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC(F)(F)F)cc1)CC2 CHEMBL2331650 EC50 4.7 nM
COCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 CHEMBL4794753 EC50 4.7 nM
N[C@@H](CC(=O)N1CCCN(CC(=O)NCCOCCOCCOCCOCCOCCNC(=O)CCc2cc(Cl)c(Oc3ccsc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)C(=O)C1Cc1ccccc1)Cc1cc(F)c(F)cc1F CHEMBL5439914 EC50 4.9 nM
C[C@H](O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 CHEMBL4873170 EC50 5.07 nM
CN1CCN(C(=O)C2(C(=O)Nc3cc(Cl)ccc3Cl)CC2)c2ccccc21 CHEMBL3321850 EC50 5.1 nM
CCOC(=O)Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 CHEMBL3290721 EC50 5.2 nM
COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 CHEMBL2336238 EC50 5.5 nM
CC(=O)c1cccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 CHEMBL3290739 EC50 5.5 nM
CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@]3(C)[C@@H]([C@H](C)CCc4nnc(C)o4)CC[C@H]3[C@H]12 CHEMBL4519596 EC50 5.59 nM
Fc1ccccc1-c1ccncc1CN1C(c2ccco2)=NOC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1Cl CHEMBL5268028 EC50 5.6 nM
COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4)cc3F)n2-c2ccc(F)cc2)cc1OC CHEMBL3793388 EC50 5.8 nM
CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 CHEMBL3234571 EC50 6.0 nM
Cc1ccccc1[C@H](C/C(=N/O)c1ccc(=O)n(C)n1)c1ccc(Br)cc1 CHEMBL5272181 EC50 6.0 nM
CN1CCN(C(=O)c2cccnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 CHEMBL3321841 EC50 6.1 nM
N[C@@H](CC(=O)N1CCCN(CC(=O)NCCOCCOCCOCCNC(=O)CCc2cc(Cl)c(Oc3ccsc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)C(=O)C1Cc1ccccc1)Cc1cc(F)c(F)cc1F CHEMBL5413666 EC50 6.1 nM
C=CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 CHEMBL2181238 EC50 6.2 nM
Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC[C@@H]1c1cccnc1 CHEMBL2336222 EC50 6.8 nM
O=C(c1cncn1Cc1ccc(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 CHEMBL4759025 EC50 6.8 nM
CSCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 CHEMBL4783037 EC50 7.0 nM
CS(=O)(=O)c1ccc(CC2CCC(c3c(C(=O)N4CCC(c5ccc(F)cc5)C4)cnn3-c3ccc(F)cc3)CC2)cc1 CHEMBL5283173 EC50 7.0 nM
O=C(c1ccncc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 CHEMBL5280567 EC50 7.0 nM
CCCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 CHEMBL2181236 EC50 7.1 nM
Cc1c(Br)oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 CHEMBL3290718 EC50 7.7 nM
COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4cccc4)cc3)n2-c2ccc(F)cc2)cc1OC CHEMBL3792957 EC50 7.8 nM
O=C(c1cnccc1Oc1cccc(Cl)c1)N1CCN(C2CC2)c2ccccc21 CHEMBL2181222 EC50 7.9 nM
Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CC1 CHEMBL2336236 EC50 7.9 nM
Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1cccnc1 CHEMBL2336211 EC50 7.9 nM
Cc1onc(-c2cccc(F)c2)c1C(=O)N(C)c1ccc(Cl)cc1 CHEMBL601440 pEC50 7.943 nM
Cc1ccccc1C(C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(Br)cc1 CHEMBL2407951 EC50 8.0 nM
CN1CCN(c2cc(N3CCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 CHEMBL3234575 EC50 8.0 nM
Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)ncc1F CHEMBL3234555 EC50 8.0 nM
COc1cccc(-c2noc(C3CC3)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 CHEMBL3132971 EC50 8.2 nM
CCOC(=O)CNC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C CHEMBL3290733 EC50 8.5 nM
COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4C)cc3F)n2-c2ccc(F)cc2)cc1OC CHEMBL3793168 EC50 8.6 nM
CCOC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C CHEMBL3290731 EC50 8.9 nM
COc1cc(F)ccc1-c1ccncc1N(C)C(=O)c1cc(C(F)(F)F)cc(S(=O)(=O)N2CC3(COC3)C2)c1 CHEMBL5286933 EC50 9.0 nM
CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC)cc1)CC2 CHEMBL2331645 EC50 9.2 nM
O=C(c1cncn1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 CHEMBL4744582 EC50 9.5 nM
CCCc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 CHEMBL601637 pEC50 10.0 nM
CCc1onc(-c2ccccc2Cl)c1C(=O)N(CC)c1ccc(Cl)cc1 CHEMBL605367 pEC50 10.0 nM
O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 CHEMBL2181246 EC50 10.0 nM
COc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 CHEMBL3132969 EC50 10.0 nM
CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 CHEMBL4847424 EC50 10.06 nM
CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@]3(C)[C@@H]([C@H](C)CCC(=O)N4CCCC4)CC[C@H]3[C@H]12 CHEMBL4519993 EC50 10.5 nM
O=C(c1cnccc1Oc1ccc2occc2c1)N1CCN(C2CC2)c2ccccc21 CHEMBL3290706 EC50 10.7 nM
Cc1cc(/C(C[C@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 CHEMBL2408107 EC50 11.0 nM
CCc1onc(-c2cccc(OC)c2)c1C(=O)N(C)c1ccc(C(F)(F)F)nc1 CHEMBL3132970 EC50 11.0 nM
COc1cc(C2CCN(c3cc(N4CC[C@H]4C(=O)NCCc4ccc(C#N)cc4)nc(C(F)(F)F)n3)CC2)ccc1C(=O)O CHEMBL3234869 EC50 11.0 nM
O=C(O)CCc1cc(Cl)c(Oc2ccsc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl CHEMBL5399395 EC50 11.2 nM
Cc1ccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1 CHEMBL2181225 EC50 12.0 nM
COc1ccc(OC)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 CHEMBL2181224 EC50 12.0 nM
COc1cccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 CHEMBL2181223 EC50 12.0 nM
Cc1nn(C)c(Oc2ccc(Cl)cc2Cl)c1C(=O)N1CCCCC1c1cccnc1 CHEMBL2336213 EC50 12.0 nM
Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(Br)cc1 CHEMBL2407949 EC50 12.0 nM
CC1(C(=O)O)CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 CHEMBL3234581 EC50 12.0 nM
CSc1ncc(C(=O)N2CCN(C)c3ccccc32)c(Oc2cc(Cl)ccc2Cl)n1 CHEMBL3321843 EC50 12.0 nM
Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1cc(Br)c(C)c(Br)c1 CHEMBL590495 pEC50 12.59 nM
Cc1onc(-c2cccc(Cl)c2)c1C(=O)N(C)c1ccc(Cl)cc1 CHEMBL601441 pEC50 12.59 nM
Cc1onc(-c2ccc(Cl)cc2)c1C(=O)N(C)c1ccc(Cl)cc1 CHEMBL600821 pEC50 12.59 nM
Cc1ccccc1-c1noc(C)c1C(=O)N(C)c1ccc(Cl)cc1 CHEMBL604537 pEC50 12.59 nM
CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 CHEMBL604131 pEC50 12.59 nM
Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)ncc1F CHEMBL3234561 EC50 13.0 nM
CCNC(=O)O[C@@H]1CC[C@]2(C)[C@H]3CC[C@@H]4[C@H]5[C@H](C(C)C)CC[C@]5(C(=O)O)CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C CHEMBL4856750 EC50 13.04 nM
CC(=O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 CHEMBL4869294 EC50 13.11 nM
Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(C)Cc1cccnc1 CHEMBL2336235 EC50 14.0 nM
N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(Oc5ccc(CC(=O)O)cc5)CC4)nc(C(F)(F)F)n3)C2)cc1 CHEMBL3234582 EC50 14.0 nM
N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cc1 CHEMBL3234569 EC50 14.0 nM
O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCN(C2COC2)c2ccccc21 CHEMBL5286949 EC50 14.0 nM
COc1ccccc1COC(=O)C1=C(C)N(C[C@H]2CCCO2)C(=O)C[C@H]1c1ccc(Cl)cc1 CHEMBL5417359 EC50 14.0 nM
COc1ccc(C(C)(C)c2cnc(SCCOCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC CHEMBL4126485 EC50 14.4 nM
CC1C(=O)N(CC(=O)NCCN(C)C(=O)CCc2cc(Cl)c(Oc3ccsc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL5483060 EC50 14.9 nM
Cc1nn(C)c(Oc2ccccc2C(F)(F)F)c1C(=O)N1CCCCC1c1cccnc1 CHEMBL2336216 EC50 15.0 nM
Cc1nn(C)c(Oc2ccccc2Cl)c1C(=O)N1CCCCC1c1cccnc1 CHEMBL2336210 EC50 15.0 nM
N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 CHEMBL3234871 EC50 15.0 nM
O=C(c1cnccc1Oc1ccc2ncsc2c1)N1CCN(C2CC2)c2ccccc21 CHEMBL3290712 EC50 15.0 nM
Fc1ccccc1-c1ccncc1CN1C(c2ccco2)=NOC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL5276894 EC50 15.0 nM
Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Br)cc1 CHEMBL600827 pEC50 15.85 nM
O=C(c1cnccc1Oc1ccc2sccc2c1)N1CCN(C2CC2)c2ccccc21 CHEMBL3290711 EC50 16.0 nM
CCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 CHEMBL4798091 EC50 16.4 nM
COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4cncn4)cc3)n2-c2ccc(F)cc2)cc1OC CHEMBL3794111 EC50 16.8 nM
N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3nccc(C(F)(F)F)n3)C2)cc1 CHEMBL3234562 EC50 17.0 nM
O=C(c1cnccc1Oc1cccc2ccccc12)N1CCN(C2CC2)c2ccccc21 CHEMBL3290700 EC50 17.0 nM
COc1ccc(C(C)(C)c2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC CHEMBL3794175 EC50 17.0 nM
COc1ccc(C(C)(C)c2cnc(SCCOCc3cccc(Cl)c3)n2-c2ccc(F)cc2)cc1OC CHEMBL4128655 EC50 17.2 nM
CNC(=O)O[C@@H]1CC[C@]2(C)[C@H]3CC[C@@H]4[C@H]5[C@H](C(C)C)CC[C@]5(C(=O)O)CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C CHEMBL4856752 EC50 17.81 nM
Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CCOC1 CHEMBL2336237 EC50 18.0 nM
N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(C(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 CHEMBL3234868 EC50 18.0 nM
CCOC(=O)CCc1oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C CHEMBL3290735 EC50 18.0 nM
CC1(C)[C@H](OC(=O)NC2CC2)CC[C@]2(C)[C@H]3CC[C@@H]4[C@H]5[C@H]([C@@]6(C)CO6)CC[C@]5(C(=O)O)CC[C@@]4(C)[C@]3(C)CC[C@@H]12 CHEMBL4877060 EC50 18.63 nM
CCN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)nc3)nc(C(F)(F)F)n2)CC1 CHEMBL3234579 EC50 19.0 nM
COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4cccn4)cc3)n2-c2ccc(F)cc2)cc1OC CHEMBL3793859 EC50 19.6 nM
Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1C CHEMBL598743 pEC50 19.95 nM
Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C(F)(F)F)cc1 CHEMBL599328 pEC50 19.95 nM
Cc1onc(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 CHEMBL601882 pEC50 19.95 nM
CC(C)c1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 CHEMBL603921 pEC50 19.95 nM
CCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 CHEMBL2181252 EC50 20.0 nM
Cc1cc(/C(CC(c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 CHEMBL2407954 EC50 20.0 nM
CN1CCN(c2cc(N3CCCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 CHEMBL3234574 EC50 20.0 nM
CN1CCN(C(=O)c2cnc(O)nc2Nc2cc(Cl)ccc2Cl)c2ccccc21 CHEMBL3321758 EC50 20.0 nM
COc1cc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)ccc1F CHEMBL4094487 EC50 20.0 nM
COc1ccc(C(C)(C)c2cnc(SCCOCc3cccc(C#N)c3)n2-c2ccc(F)cc2)cc1OC CHEMBL4130025 EC50 21.6 nM
O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CCC2)c2ccccc21 CHEMBL2181231 EC50 23.0 nM
Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl CHEMBL576138 EC50 23.0 nM
Cc1cc(/C(C[C@@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 CHEMBL2407931 EC50 23.0 nM
Cc1c(Cl)cccc1OCCCC(=O)N1CCCc2c(-c3cnn(Cc4c(F)cc(C(=O)NCCS(=O)(=O)O)cc4Cl)c3)cccc21 CHEMBL5270683 EC50 23.0 nM
O=C(OCC(F)(F)F)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 CHEMBL4784355 EC50 23.3 nM
CC[C@H]1[C@@H](O)[C@@H]2[C@H](CC[C@]3(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@@H]23)[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL566315 EC50 23.7 nM
COC(=O)CCc1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 CHEMBL3290722 EC50 24.0 nM
COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC CHEMBL4060410 EC50 24.0 nM
Cc1c(Cl)cccc1OCCCC(=O)N1CCC(Cc2cccc(C(=O)NCCS(=O)(=O)O)c2)c2ccccc21 CHEMBL5284578 EC50 24.0 nM
Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(N(C)C)cc1 CHEMBL2407944 EC50 25.0 nM
N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc(-c4ccc(C(=O)O)cc4)cc3)nc(C(F)(F)F)n2)cc1 CHEMBL3234870 EC50 25.0 nM
O=C(c1cnccc1Oc1ccc2ccoc2c1)N1CCN(C2CC2)c2ccccc21 CHEMBL3290707 EC50 25.0 nM
Cc1c(/C=C/C(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 CHEMBL3290732 EC50 25.0 nM
O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 CHEMBL4205214 pEC50 25.12 nM
O=C([C@@H]1CSCN1Cc1cc(Cl)c(CO)cc1Cl)N1CCN(C2CC2)c2ccccc21 CHEMBL4216682 pEC50 25.12 nM
CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl CHEMBL4204655 pEC50 25.12 nM
COCC(=O)O[C@@H]1CC[C@]2(C)[C@H]3CC[C@@H]4[C@H]5[C@H](C(C)C)CC[C@]5(C(=O)O)CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C CHEMBL4860100 EC50 25.25 nM
Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 CHEMBL2407934 EC50 26.0 nM
N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(C(=O)O)CC4)nc(C(F)(F)F)n3)C2)cc1 CHEMBL3234580 EC50 26.0 nM
Cc1cc(NC(=O)c2cc(Cl)c(Oc3ncccc3C(=O)N3CCCc4ccccc43)cc2Cl)sc1C(=O)O CHEMBL5289884 EC50 26.0 nM
CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CCC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 CHEMBL4873169 EC50 26.69 nM
CCCNC(=O)O[C@@H]1CC[C@]2(C)[C@H]3CC[C@@H]4[C@H]5[C@H](C(C)C)CC[C@]5(C(=O)O)CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C CHEMBL4874555 EC50 26.88 nM
CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)CO)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 CHEMBL4875868 EC50 26.96 nM
O=C(c1cnccc1Oc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 CHEMBL2181221 EC50 27.0 nM
Cc1cc(/C(CC(c2ccc(Br)cc2)c2ccccc2C)=N/O)ccn1 CHEMBL2407950 EC50 28.0 nM
Cc1ccccc1[C@H](C/C(=N/O)C1CCC(=O)N(C)C1)c1ccc(S(C)(=O)=O)cc1 CHEMBL5281639 EC50 29.0 nM
CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CCCC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 CHEMBL4867540 EC50 29.19 nM
C=CCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 CHEMBL2181255 EC50 30.0 nM
CCCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 CHEMBL2181253 EC50 30.0 nM
N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(CC(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 CHEMBL3234583 EC50 30.0 nM
CCOC(=O)CNC(=O)CCc1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C CHEMBL3290737 EC50 30.0 nM
COC(=O)CN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccccc2OC)=C1C CHEMBL5437561 EC50 30.0 nM
CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(N)=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 CHEMBL4852436 EC50 30.7 nM
O=C(c1ccccc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL2435932 EC50 31.0 nM
COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-c4nccs4)cc3)n2-c2ccc(F)cc2)cc1OC CHEMBL3794424 EC50 31.5 nM
Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 CHEMBL575966 pEC50 31.62 nM
Cc1onc(-c2ccccc2C(F)(F)F)c1C(=O)N(C)c1ccc(Cl)cc1 CHEMBL604543 pEC50 31.62 nM
CCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1ccc(Cl)cc1 CHEMBL600833 pEC50 31.62 nM
O=C(CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO CHEMBL4213844 pEC50 31.62 nM
O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO CHEMBL4217797 pEC50 31.62 nM
O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO CHEMBL4213913 pEC50 31.62 nM
COc1ccccc1COC(=O)C1=C(C)N(C[C@@H]2CCCO2)C(=O)C[C@H]1c1ccc(Cl)nc1 CHEMBL5395730 pEC50 31.62 nM
O=C(c1ccco1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL2435933 EC50 32.0 nM
Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Br)cc3)C2)n1 CHEMBL3234552 EC50 33.0 nM
CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@]3(C)[C@@H]([C@H](C)CCC(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)CC[C@H]3[C@H]12 CHEMBL4778769 EC50 33.3 nM
Cc1c(/C=C/C(=O)NCC(=O)O)oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 CHEMBL3290734 EC50 34.0 nM
N#CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL2435924 EC50 35.0 nM
Cc1c(CCC(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 CHEMBL3290736 EC50 35.0 nM
COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)c(Cl)c2)cc1OC CHEMBL4090147 EC50 35.0 nM
COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC CHEMBL4084668 EC50 35.0 nM
CC(C)(c1ccc(Cl)c(Cl)c1)c1cnc(SCCOCc2c(F)cccc2Cl)n1-c1ccc(F)cc1 CHEMBL4127444 EC50 35.7 nM
C[C@@H](O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 CHEMBL4861151 EC50 37.99 nM
CCN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4cnc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 CHEMBL3234573 EC50 38.0 nM
CCOC(=O)c1oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2c1C CHEMBL3290719 EC50 38.0 nM
COc1ccc(C(C)(C)c2cnc(SCCOc3ccccc3)n2-c2ccc(F)cc2)cc1OC CHEMBL3794293 EC50 38.0 nM
Cc1onc(-c2ccccc2Cl)c1C(=O)N(c1ccc(Cl)cc1)C(C)C CHEMBL600834 pEC50 39.81 nM
O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1C(F)(F)F)N1CCN(C2CC2)c2ccccc21 CHEMBL4215354 pEC50 39.81 nM
O=C(CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO CHEMBL4209927 pEC50 39.81 nM
O=C(c1cnccc1Oc1cccc2ncccc12)N1CCN(C2CC2)c2ccccc21 CHEMBL3290702 EC50 40.0 nM
O=C(c1cnccc1Oc1ccc2ccccc2c1)N1CCN(C2CC2)c2ccccc21 CHEMBL3290701 EC50 41.0 nM
CSc1ncc(C(=O)N2CCNc3ccccc32)c(Oc2cc(Cl)ccc2Cl)n1 CHEMBL3321844 EC50 41.0 nM
CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)nc1)CC2 CHEMBL2331652 EC50 43.0 nM
COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccncc3)nc2c1 CHEMBL1258758 IC50 44.0 nM
CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccc2)cc1 CHEMBL2407936 EC50 45.0 nM
CNS(=O)(=O)O[C@@H]1CC[C@]2(C)[C@H]3CC[C@@H]4[C@H]5[C@H](C(C)C)CC[C@]5(C(=O)O)CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C CHEMBL4865346 EC50 45.37 nM
O=C(c1cnccc1Oc1ccccc1)N1CCN(C2CC2)c2ccccc21 CHEMBL2181220 EC50 47.0 nM
COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2F)cc1OC CHEMBL4068227 EC50 47.0 nM
O=C(O)CCc1cc(Cl)c(Oc2ncccc2C(=O)N2CCCc3ccccc32)cc1Cl CHEMBL5286406 EC50 47.0 nM
O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 CHEMBL2181251 EC50 48.0 nM
CC1C(=O)N(CC(=O)N(CCOCCOCCOCCOCCOCCOCCOCCOCCN(CC(=O)O)C(=O)CCc2cc(Cl)c(Oc3ccsc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)CC(=O)O)CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F CHEMBL5398966 EC50 48.5 nM
O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 CHEMBL2181233 EC50 49.0 nM
COCCOCCNC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@H](OC)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL4759021 EC50 49.5 nM
O=C([C@@H]1C[C@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 CHEMBL4206153 pEC50 50.12 nM
O=C(O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl CHEMBL4207005 pEC50 50.12 nM
N#CC(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL2435926 EC50 51.0 nM
O=C(c1ccsc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL2435914 EC50 53.0 nM
Cc1cc(/C(C[C@@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 CHEMBL2407929 EC50 57.0 nM
O=C(c1cnccc1Oc1ccc2cccnc2c1)N1CCN(C2CC2)c2ccccc21 CHEMBL3290704 EC50 59.0 nM
Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 CHEMBL2407932 EC50 60.0 nM
Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 CHEMBL3234549 EC50 60.0 nM
N#CC(NCc1cnccc1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL2435925 EC50 61.0 nM
O=S(=O)(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL2435928 EC50 62.0 nM
CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@]3(C)[C@@H]([C@H](C)CCC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)CC[C@H]3[C@H]12 CHEMBL4789628 EC50 62.3 nM
O=S(=O)(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL2435927 EC50 63.0 nM
N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cn1 CHEMBL3234572 EC50 63.0 nM
Cc1c(C(=O)O)oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 CHEMBL3290723 EC50 63.0 nM
O=C(O)CNC(=O)CCc1cc(Cl)c(Oc2ncccc2C(=O)N2CCCc3ccccc32)cc1Cl CHEMBL5273781 EC50 63.0 nM
Cc1cc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)ccc1Cl CHEMBL600020 pEC50 63.1 nM
COc1ccccc1-c1noc(C)c1C(=O)N(C)c1ccc(Cl)cc1 CHEMBL603500 pEC50 63.1 nM
CCc1onc(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 CHEMBL601428 pEC50 63.1 nM
O=C([C@@H]1C[C@@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 CHEMBL4202908 pEC50 63.1 nM
CN(C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl CHEMBL4202603 pEC50 63.1 nM
CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl CHEMBL4218315 pEC50 63.1 nM
O=C(c1cnccc1Oc1ccc2ncccc2c1)N1CCN(C2CC2)c2ccccc21 CHEMBL3290703 EC50 64.0 nM
COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 CHEMBL1258423 IC50 65.0 nM
COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccnc3)nc2c1 CHEMBL1258759 IC50 65.0 nM
Cc1nn(C)c(Oc2cccc(F)c2F)c1C(=O)N1CCCCC1c1cccnc1 CHEMBL2336212 EC50 65.0 nM
CC(C)(c1ccc(Cl)c(Cl)c1)c1cnc(SCCOCc2ccc(C#N)cc2)n1-c1ccc(F)cc1 CHEMBL4128688 EC50 67.5 nM
O=C(NCCO)c1cc(Cl)c(Oc2ncccc2C(=O)N2CCCc3ccccc32)cc1Cl CHEMBL5275121 EC50 68.0 nM
CCNS(=O)(=O)O[C@@H]1CC[C@]2(C)[C@H]3CC[C@@H]4[C@H]5[C@H](C(C)C)CC[C@]5(C(=O)O)CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C CHEMBL4863256 EC50 68.59 nM
CC(C)N1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 CHEMBL2181237 EC50 69.0 nM
COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CCN(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC CHEMBL4104359 EC50 71.0 nM
COc1cc(F)ccc1-c1ccnnc1N(C)C(=O)c1cc(C(F)(F)F)cc(S(C)(=O)=O)c1 CHEMBL5267358 EC50 75.0 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccccc2OC)=C1C CHEMBL5409356 EC50 75.0 nM
CC1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@]3(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@H]3[C@H]12 CHEMBL270105 EC50 76.0 nM
Cc1cc(N2CCN(C)CC2)nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 CHEMBL3234564 EC50 76.0 nM
O=C(Nc1nnn[nH]1)c1cc(Cl)c(Oc2ncccc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl CHEMBL5281159 EC50 76.0 nM
CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@]3(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@H]3[C@H]12 CHEMBL4790399 EC50 76.8 nM
COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCN(CCS(=O)(=O)O)CCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC CHEMBL4087611 EC50 77.0 nM
CCCS(=O)(=O)O[C@@H]1CC[C@]2(C)[C@H]3CC[C@@H]4[C@H]5[C@H](C(C)C)CC[C@]5(C(=O)O)CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C CHEMBL4853647 EC50 77.63 nM
CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C)cc1)CC2 CHEMBL2331644 EC50 78.0 nM
CCOC(=O)CNC(=O)c1oc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2c1C CHEMBL3290727 EC50 78.0 nM
Cc1cccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)c1 CHEMBL2407945 EC50 79.0 nM
Fc1ccccc1-c1ccncc1CN1C(c2ccccc2)=NOC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL5274626 EC50 79.0 nM
Cc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)c1 CHEMBL602892 pEC50 79.43 nM
CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl CHEMBL4207801 pEC50 79.43 nM
Cn1c(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl CHEMBL4209669 pEC50 79.43 nM
O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO CHEMBL4206078 pEC50 79.43 nM
Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 CHEMBL2407935 EC50 80.0 nM
CCOC(=O)O[C@@H]1CC[C@]2(C)[C@H]3CC[C@@H]4[C@H]5[C@H](C(C)C)CC[C@]5(C(=O)O)CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C CHEMBL4866697 EC50 80.04 nM
COCCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 CHEMBL4793377 EC50 81.5 nM
Oc1ccc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2c1 CHEMBL1257612 IC50 82.0 nM
CCCC(=O)O[C@@H]1CC[C@]2(C)[C@H]3CC[C@@H]4[C@H]5[C@H](C(C)C)CC[C@]5(C(=O)O)CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C CHEMBL4873587 EC50 83.12 nM
O=C(OCCl)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 CHEMBL4778884 EC50 83.7 nM
C=CCN(c1ccc(OC)c(OC)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 CHEMBL4081050 EC50 86.0 nM
CN(C(=O)c1c(-c2ccc(F)cc2)nc2ncccn12)c1ccc(Cl)cc1 CHEMBL5272787 EC50 90.0 nM
COc1ccc(C(C)(C)c2cnc(S(=O)(=O)CCOCc3ccc(C#N)cc3)n2-c2ccc(F)cc2)cc1OC CHEMBL4128816 EC50 94.7 nM
CC[C@@H]1C2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@]3(C)[C@@H]([C@H](C)C[C@H](C)C(=O)O)CC[C@H]3[C@@H]2[C@@H]1O CHEMBL244785 EC50 95.0 nM
CC[C@H]1[C@@H](O)[C@@H]2[C@H](CC[C@]3(C)[C@@H]([C@H](C)C[C@H](O)C(=O)O)CC[C@@H]23)[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL566985 EC50 95.0 nM
O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncc(F)cn2)C1 CHEMBL3234554 EC50 95.0 nM
CC[C@H]1[C@@H](O)[C@@H]2[C@H](C[C@H](O)[C@]3(C)[C@@H]([C@H](C)C[C@H](C)C(=O)O)CC[C@@H]23)[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL567640 EC50 95.8 nM
COc1ccc2cc(CNCCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 CHEMBL1258311 IC50 97.0 nM
CO[C@@H]1CC[C@@]2(C)[C@@H](C1)C[C@@H](OC)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)CCC(=O)N3CCCC3)CC[C@@H]12 CHEMBL4084918 EC50 97.3 nM
Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)c(Cl)c1 CHEMBL590982 pEC50 100.0 nM
Cc1ccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)cc1 CHEMBL2407946 EC50 100.0 nM
O=C([C@@H]1CSCN1Cc1cc(Cl)c(O)cc1Cl)N1CCN(C2CC2)c2ccccc21 CHEMBL4203848 pEC50 100.0 nM
O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 CHEMBL4207707 pEC50 100.0 nM
O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 CHEMBL4216584 pEC50 100.0 nM
O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccn(Cc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)n1 CHEMBL4216361 pEC50 100.0 nM
Cn1nc(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cc1OCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl CHEMBL4208057 pEC50 100.0 nM
O=C(NCCCCOc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO CHEMBL4213391 pEC50 100.0 nM
O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO CHEMBL4208999 pEC50 100.0 nM
C=CC[C@@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL4642126 EC50 100.0 nM
CCC(C)Oc1cccc(OCc2ccc3ccccc3n2)c1 CHEMBL5192002 EC50 100.0 nM
COC(=O)CN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccccc2)=C1C CHEMBL5415202 EC50 100.0 nM
COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(Cl)cn2)c1 CHEMBL3132967 EC50 102.0 nM
COc1ccccc1COC(=O)C1=C(C)N(C[C@@H]2CCCO2)C(=O)C[C@H]1c1ccc(Cl)cc1 CHEMBL5421793 EC50 110.0 nM
Cc1ccc(Oc2c(C(=O)N3CCCCC3c3cccnc3)c(C)nn2C)c(Cl)c1 CHEMBL2336215 EC50 113.0 nM
CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)C[C@H](C)C(=O)O)[C@H]3[C@@H](O)C[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@H]12 CHEMBL4866257 EC50 116.6 nM
O=C(c1cncn1Cc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 CHEMBL4796107 EC50 118.0 nM
CCOC(=O)CNC(=O)CCc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 CHEMBL3290730 EC50 119.0 nM
C[C@H](CCCO)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL270287 EC50 120.0 nM
C=CC[C@]1(O)CC[C@]2(C)[C@H]3CC[C@@H]4[C@H]5[C@H](C(=C)C)CC[C@]5(C(=O)O)CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C CHEMBL585494 EC50 120.0 nM
Cc1nn(C)c(Oc2cccc(Cl)c2F)c1C(=O)N1CCCCC1c1cccnc1 CHEMBL2336239 EC50 120.0 nM
O=C(c1ccsc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 CHEMBL2435943 EC50 120.0 nM
CN1CCN(C(=O)C2(C(=O)Nc3cc(F)c(F)cc3F)CC2)c2ccccc21 CHEMBL3356914 EC50 122.0 nM
CC(C)NC(=O)O[C@@H]1CC[C@]2(C)[C@H]3CC[C@@H]4[C@H]5[C@H](C(C)C)CC[C@]5(C(=O)O)CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C CHEMBL4846090 EC50 123.9 nM
Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(I)cc1 CHEMBL600421 pEC50 125.89 nM
Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 CHEMBL600629 pEC50 125.89 nM
O=C([C@@H]1CC(F)(F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 CHEMBL4218210 pEC50 125.89 nM
CO[C@@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 CHEMBL4203445 pEC50 125.89 nM
O=C([C@@H]1CSCN1Cc1cc(I)ccc1Cl)N1CCN(C2CC2)c2ccccc21 CHEMBL4206320 pEC50 125.89 nM
O=C(CCc1cc(Cl)c(CN2CCC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO CHEMBL4203191 pEC50 125.89 nM
O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 CHEMBL4202981 pEC50 125.89 nM
O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCOc2ccccc21 CHEMBL2181234 EC50 127.0 nM
COc1ccc(N(C)c2cnc(SCc3ccccc3F)n2-c2ccc(F)cc2)cc1OC CHEMBL4075688 EC50 128.0 nM
CO/N=C(/C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 CHEMBL4846185 EC50 131.6 nM
COc1cccc(-c2nnn(C)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 CHEMBL3132972 EC50 135.0 nM
CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC)cc1)CC2 CHEMBL2331647 EC50 137.0 nM
CCOC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 CHEMBL4794523 EC50 137.0 nM
C[C@H](C[C@H](C)C(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)[C@H](C)C4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL244784 EC50 140.0 nM
CC[C@H]1[C@@H](O)[C@@H]2[C@H](CC[C@]3(C)[C@@H]([C@H](C)C[C@H](C)C(=O)O)CC[C@@H]23)[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL1258080 IC50 140.0 nM
N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ccnc(C(F)(F)F)n3)C2)cc1 CHEMBL3234563 EC50 140.0 nM
CC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 CHEMBL4782069 EC50 145.0 nM
O=C(c1cnccc1Oc1cccc2[nH]ccc12)N1CCN(C2CC2)c2ccccc21 CHEMBL3290709 EC50 148.0 nM
COc1ccc(N(C)c2cnc(SCc3ccccc3)n2-c2ccc(F)cc2)cc1OC CHEMBL4085664 EC50 156.0 nM
Cc1onc(-c2ccccc2F)c1C(=O)N(C)c1ccc(Cl)cc1 CHEMBL601233 pEC50 158.49 nM
O=C([C@@H]1C[C@@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 CHEMBL4211041 pEC50 158.49 nM
COc1ccccc1N(C)C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl CHEMBL2181244 EC50 160.0 nM
COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 CHEMBL3132968 EC50 160.0 nM
CC[C@H]1[C@@H](O)[C@@H]2[C@H](CC[C@]3(C)[C@@H]([C@H](C)CCNC(=O)N4CC[C@H](O)C4)CC[C@@H]23)[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL4170310 EC50 160.0 nM
O=C(c1cnccc1Oc1ccc2cc[nH]c2c1)N1CCN(C2CC2)c2ccccc21 CHEMBL3290710 EC50 162.0 nM
O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCSc2ccccc21 CHEMBL2181232 EC50 164.0 nM
CCC(C)COc1cccc(OCc2ccc3ccccc3n2)c1 CHEMBL5173976 EC50 170.0 nM
CC(C)[C@@H]1CC[C@]2(NC(=O)NCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 CHEMBL4847526 EC50 173.7 nM
CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)Nc6cc[nH]n6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 CHEMBL4846632 EC50 174.9 nM
COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC CHEMBL4086463 EC50 177.0 nM
O=C(c1cnccc1Oc1cccc2cccnc12)N1CCN(C2CC2)c2ccccc21 CHEMBL3290705 EC50 178.0 nM
O=C(Nc1cc(Cl)ccc1Cl)C1(C(=O)N2CCNc3ccccc32)CC1 CHEMBL3321849 EC50 178.0 nM
COCCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccccc2OC)=C1C CHEMBL5405469 EC50 190.0 nM
O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 CHEMBL4203777 pEC50 199.53 nM
CO[C@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 CHEMBL4215113 pEC50 199.53 nM
NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl CHEMBL4211892 pEC50 199.53 nM
O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 CHEMBL4206832 pEC50 199.53 nM
O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cn1 CHEMBL4202994 pEC50 199.53 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2cccc(F)c2)=C1C CHEMBL5412722 pEC50 199.53 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2cccc(Cl)c2)=C1C CHEMBL5408901 pEC50 199.53 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2cccc(C)c2)=C1C CHEMBL5400262 pEC50 199.53 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2c(C)cc(C)cc2C)=C1C CHEMBL5439826 pEC50 199.53 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccc(OC)cc2)=C1C CHEMBL5422305 pEC50 199.53 nM
COc1ccccc1COC(=O)C1=C(C)N(C[C@H]2CCCO2)C(=O)C[C@@H]1c1ccc(Cl)nc1 CHEMBL5394197 pEC50 199.53 nM
CC[C@H]1[C@@H](O)[C@@H]2[C@H](CC[C@]3(C)[C@@H]([C@H](C)CCCOS(=O)(=O)[O-])CC[C@@H]23)[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL3260994 EC50 200.0 nM
CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL2435921 EC50 204.0 nM
CC[C@H]1[C@@H](O)[C@@H]2[C@H](CC[C@]3(C)[C@@H]([C@H](C)CCC(=O)NCCS(=O)(=O)O)CC[C@@H]23)[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL4071018 EC50 205.0 nM
CCN(C)C(=O)O[C@@H]1CC[C@]2(C)[C@H]3CC[C@@H]4[C@H]5[C@H](C(C)C)CC[C@]5(C(=O)O)CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C CHEMBL4877942 EC50 211.2 nM
Cc1cccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 CHEMBL3234559 EC50 220.0 nM
C[C@H](C[C@H](C)C(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL3401351 EC50 220.0 nM
CC(C[C@H](C)C(=O)O)[C@H]1CCC2C3CC[C@@H]4C[C@H](O)CC[C@]4(C)C3CC[C@@]21C CHEMBL5268940 EC50 220.0 nM
Cc1nnc(CC[C@@H](C)[C@H]2CC[C@H]3[C@@H]4[C@H](O)C[C@@H]5C[C@H](O)CC[C@]5(C)[C@H]4CC[C@]23C)o1 CHEMBL4470072 EC50 223.0 nM
Fc1ccc(-n2c(COc3cccc4cnccc34)nc3ccccc32)c(Cl)c1 CHEMBL5286375 EC50 229.0 nM
COc1ccc(NC(=O)O[C@@H]2CC[C@]3(C)[C@H]4CC[C@@H]5[C@H]6[C@H](C(C)C)CC[C@]6(C(=O)O)CC[C@@]5(C)[C@]4(C)CC[C@H]3C2(C)C)cc1 CHEMBL4854339 EC50 229.9 nM
COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCC[N+]45CCN(CC4)CC5)cc3F)n2-c2ccc(F)cc2)cc1OC CHEMBL4078612 EC50 238.0 nM
Cc1noc2cc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)ccc12 CHEMBL3290714 EC50 240.0 nM
CC[C@H]1[C@@H](O)[C@@H]2[C@H](CC[C@]3(C)[C@@H]([C@H](C)CCNC(=O)C(=O)O)CC[C@@H]23)[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL4164682 EC50 240.0 nM
CC[C@H]1[C@@H](O)[C@@H]2[C@H](CC[C@]3(C)[C@@H]([C@H](C)CCNC(=O)O[C@H]4CCOC4)CC[C@@H]23)[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL4160849 EC50 240.0 nM
C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](F)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL273087 EC50 250.0 nM
C[C@]12C=CC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO CHEMBL131 IC50 251.0 nM
Cc1cc(Cl)ccc1N(C)C(=O)c1c(-c2ccccc2Cl)noc1C CHEMBL600021 pEC50 251.19 nM
O=C([C@@H]1COCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 CHEMBL4213036 pEC50 251.19 nM
CC1(C)SC[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N1Cc1cc(Cl)ccc1Cl CHEMBL4210686 pEC50 251.19 nM
O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)o1 CHEMBL4210547 pEC50 251.19 nM
O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1cccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)c1 CHEMBL4215045 pEC50 251.19 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccccc2F)=C1C CHEMBL5431493 pEC50 251.19 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccc(C(=O)OC)cc2)=C1C CHEMBL5424851 pEC50 251.19 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccccc2C)=C1C CHEMBL5440622 pEC50 251.19 nM
COc1ccccc1COC(=O)C1=C(C)N(Cc2ccco2)C(=O)CC1c1ccc(Cl)cc1 CHEMBL5394522 pEC50 251.19 nM
COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccccc2)cc1OC CHEMBL4104779 EC50 254.0 nM
CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccccc1)CC2 CHEMBL2331643 EC50 257.0 nM
Cc1cc(/C(CC(c2ccc(C(=O)O)cc2)c2ccccc2C)=N/O)ccn1 CHEMBL2407952 EC50 260.0 nM
O=C(c1cccs1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 CHEMBL2435942 EC50 260.0 nM
COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC CHEMBL4096633 EC50 260.0 nM
C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL410893 EC50 270.0 nM
CN(C)c1ccc(C(C/C(=N/O)c2ccncc2)c2ccccc2)cc1 CHEMBL2407938 EC50 270.0 nM
CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@H](C)CCCC(=O)NCCS(=O)(=O)[O-])[C@H]3[C@H](C)C[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL5403980 EC50 270.0 nM
CC(C)[C@@H]1CC[C@]2(NC(=O)OCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 CHEMBL4878597 EC50 270.8 nM
CN1CCN(c2cc(N3CCC[C@@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 CHEMBL3234576 EC50 274.0 nM
CCOC(=O)NCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@H](O)[C@H](CC)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL4172216 EC50 280.0 nM
CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL407717 EC50 290.0 nM
C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL408701 EC50 290.0 nM
Cc1cc(/C(CC(c2ccc(-c3cccc(C(=O)O)c3)cc2)c2ccccc2C)=N/O)ccn1 CHEMBL2407955 EC50 290.0 nM
COc1ccc(N(C)c2cnc(SCc3c(C)cccc3C)n2-c2ccc(F)cc2)cc1OC CHEMBL4081298 EC50 299.0 nM
CC[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL4647613 EC50 300.0 nM
CC1=C(C(=O)OCc2ccccc2)C(c2ccc(Cl)cc2)CC(=O)N1CC1CCC1 CHEMBL5429244 EC50 300.0 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccc(F)cc2)=C1C CHEMBL5398341 EC50 300.0 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccccc2Cl)=C1C CHEMBL5414847 EC50 300.0 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccc(C)cc2)=C1C CHEMBL5394284 EC50 300.0 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2cccc(OC)c2)=C1C CHEMBL5405338 EC50 300.0 nM
CC(C)[C@@H]1CC[C@]2(C(=O)OCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 CHEMBL4860380 EC50 306.4 nM
CC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cnccc1-c1ccccc1)C(=O)c1ccco1 CHEMBL2435945 EC50 310.0 nM
COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4F)n(-c4ccc(F)cc4)c32)cc1OC CHEMBL4060315 EC50 310.0 nM
CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@H](C)CCC(=O)NCCS(=O)(=O)[O-])[C@H]3[C@H](C)C[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL5402724 EC50 310.0 nM
CC[C@H]1[C@@H](O)[C@@H]2[C@H](CC[C@]3(C)[C@@H]([C@H](C)CCC(=O)NCC(=O)O)CC[C@@H]23)[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL4072790 EC50 315.0 nM
Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(OC(F)(F)F)cc1 CHEMBL599347 pEC50 316.23 nM
Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C#N)cc1 CHEMBL605356 pEC50 316.23 nM
Cc1onc(-c2cccc(C(F)(F)F)c2)c1C(=O)N(C)c1ccc(Cl)cc1 CHEMBL602691 pEC50 316.23 nM
CCCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1ccc(Cl)cc1 CHEMBL608867 pEC50 316.23 nM
O=C([C@@H]1CSCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 CHEMBL4217961 pEC50 316.23 nM
Cn1c(C(=O)O)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl CHEMBL4202656 pEC50 316.23 nM
COc1ccccc1COC(=O)C1=C(C)N(CCO)C(=O)CC1c1ccc(Cl)cc1 CHEMBL5425096 pEC50 316.23 nM
Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 CHEMBL2407933 EC50 320.0 nM
O=C(c1ccoc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 CHEMBL2435941 EC50 320.0 nM
Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(F)cc3)C2)n1 CHEMBL3234551 EC50 320.0 nM
COc1ccc(CN(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC CHEMBL4067717 EC50 326.0 nM
Cc1nn(C)c(Oc2ccccc2F)c1C(=O)N1CCCCC1c1cccnc1 CHEMBL2336208 EC50 337.0 nM
COc1ccc(N(C)c2c(C)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC CHEMBL4080290 EC50 337.0 nM
O=C(c1cncn1Cc1ccc(F)cc1F)N1CCN(C2CC2)c2ccccc21 CHEMBL4795121 EC50 338.0 nM
Cc1nn(C)c(Oc2cccc(Cl)c2)c1C(=O)N1CCCCC1c1cccnc1 CHEMBL2336209 EC50 349.0 nM
O=C(c1ccccc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 CHEMBL2435937 EC50 350.0 nM
O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncccn2)C1 CHEMBL3234547 EC50 350.0 nM
CCC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@]3(C)[C@@H]([C@H](C)CCC(=O)NCCS(=O)(=O)O)CC[C@H]3[C@H]12 CHEMBL260737 EC50 360.0 nM
CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccn2)cc1 CHEMBL2407947 EC50 380.0 nM
CC(C)[C@@H]1CC[C@]2(C(=O)NCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 CHEMBL4852971 EC50 380.1 nM
CCC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL2435922 EC50 384.0 nM
COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)cc1OC CHEMBL4079040 EC50 390.0 nM
Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC1c1cccnc1 CHEMBL2336227 EC50 393.0 nM
O=C(c1cccnc1Oc1cccc(C(F)(F)F)c1)N1CCCc2ccccc21 CHEMBL5279619 EC50 396.0 nM
Cc1ccccc1N(C)C(=O)c1c(-c2ccccc2Cl)noc1C CHEMBL605986 pEC50 398.11 nM
COc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 CHEMBL604751 pEC50 398.11 nM
O=C(O)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 CHEMBL4208726 pEC50 398.11 nM
O=C(CCc1cc(Cl)c(CN2C[C@@H](F)C[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO CHEMBL4214838 pEC50 398.11 nM
CC1=C(C(=O)OCc2ccccc2)C(c2ccc(Cl)cc2)CC(=O)N1CC1CC1 CHEMBL5408025 pEC50 398.11 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccc(Cl)cc2)=C1C CHEMBL5418039 pEC50 398.11 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2cccc(C(F)(F)F)c2)=C1C CHEMBL5410122 pEC50 398.11 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccccc2OC(F)(F)F)=C1C CHEMBL5396998 pEC50 398.11 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccc3ccccc3c2)=C1C CHEMBL5426387 pEC50 398.11 nM
COc1ccccc1COC(=O)C1=C(C)N(C[C@@H]2CCCO2)C(=O)C[C@@H]1c1ccc(Cl)nc1 CHEMBL5432845 pEC50 398.11 nM
CC[C@H]1[C@@H](O)[C@@H]2[C@H](CC[C@]3(C)[C@@H]([C@H](C)CCO)CC[C@@H]23)[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL3342086 EC50 400.0 nM
O=S(=O)(NCc1c(-c2ccccc2F)ccnc1Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL2435915 EC50 406.0 nM
C=C(C)C[C@]1(O)CC[C@]2(C)[C@H]3CC[C@@H]4[C@H]5[C@H](C(=C)C)CC[C@]5(C(=O)O)CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C CHEMBL571592 EC50 420.0 nM
CC[C@H]1[C@@H](O)[C@@H]2[C@H](CC[C@]3(C)[C@@H]([C@H](C)CCNC(=O)NC4CC4)CC[C@@H]23)[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL4165830 EC50 420.0 nM
COc1cc(Cl)cc(N(CC23CCC(c4ccc(OC)c(C#N)c4)(CC2)CC3)C(=O)c2ccncc2C)c1 CHEMBL5278743 EC50 420.0 nM
COc1cc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2cc1O CHEMBL1257732 IC50 430.0 nM
C[C@H](CCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL406923 EC50 440.0 nM
COC(=O)C(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL2435835 EC50 440.0 nM
Cc1nc(N2CCN(C)CC2)cc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 CHEMBL3234567 EC50 440.0 nM
COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC CHEMBL4061329 EC50 440.0 nM
CN(C(=O)c1cnccc1Oc1cc(Cl)ccc1Cl)c1ccccc1Cl CHEMBL2181219 EC50 451.0 nM
CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)N6CCOCC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 CHEMBL4850654 EC50 452.3 nM
Fc1ccccc1-c1ccncc1CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL2435919 EC50 458.0 nM
CCCN(Cc1cnccc1-c1ccccc1F)C(C#N)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL2435929 EC50 466.0 nM
O=C(c1ccco1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 CHEMBL2435940 EC50 470.0 nM
COc1ccc(Cc2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC CHEMBL4092629 EC50 470.0 nM
COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccccc3)nc2c1 CHEMBL1258646 IC50 490.0 nM
COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccco3)nc2c1 CHEMBL1258645 IC50 500.0 nM
O=C(c1ccco1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1F CHEMBL2435944 EC50 500.0 nM
CCCCOc1cccc(OCc2ccc3ccccc3n2)c1 CHEMBL18775 EC50 500.0 nM
CCCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccccc2)=C1C CHEMBL5439183 EC50 500.0 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccccc2)=C1C CHEMBL5394113 EC50 500.0 nM
CC1=C(C(=O)OCc2ccccc2)C(c2ccc(Cl)cc2)CC(=O)N1CC(C)C CHEMBL5435789 EC50 500.0 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccc(-c3ccccc3)cc2)=C1C CHEMBL5400104 EC50 500.0 nM
Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(F)cc1 CHEMBL601449 pEC50 501.19 nM
Cc1onc(-c2ccc(F)cc2)c1C(=O)N(C)c1ccc(Cl)cc1 CHEMBL591455 pEC50 501.19 nM
O=C([C@@H]1CSCN1Cc1cc(C2CC2)ccc1Cl)N1CCN(C2CC2)c2ccccc21 CHEMBL4211208 pEC50 501.19 nM
CCOC(=O)CNC(=O)Cc1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 CHEMBL3290729 EC50 520.0 nM
CC[C@H]1[C@@H](O)[C@@H]2[C@H](CC[C@]3(C)[C@@H]([C@H](C)CCc4cc(O)no4)CC[C@@H]23)[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL4175888 EC50 520.0 nM
Cc1ccccc1N(C)C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl CHEMBL2181242 EC50 535.0 nM
C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL258818 EC50 540.0 nM
C[C@H](CCC(N)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](OC=O)C[C@@H]4C[C@H](OC=O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL4449000 EC50 566.0 nM
CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@]3(C)[C@@H]([C@H](C)CCC(=O)N(CCCNC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)CCCNC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)CC[C@H]3[C@H]12 CHEMBL4791399 EC50 567.0 nM
O=C(c1cncn1Cc1ccc(F)cc1)N1CCN(C2CC2)c2ccccc21 CHEMBL4789395 EC50 568.0 nM
C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@@](C)(O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL4643368 EC50 570.0 nM
C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL1478 EC50 580.0 nM
COc1ccc2cc(CNCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 CHEMBL1258310 IC50 580.0 nM
COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccs3)nc2c1 CHEMBL1258530 IC50 580.0 nM
FC(F)(F)c1cc(CNCc2cnccc2-c2ccccc2)cc(C(F)(F)F)c1 CHEMBL2435918 EC50 580.0 nM
CC[C@H]1C[C@@H]2[C@H](CC[C@]3(C)[C@@H]([C@H](C)C[C@H](C)C(=O)O)CC[C@@H]23)[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL3401354 EC50 580.0 nM
COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL260735 EC50 590.0 nM
CCCCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 CHEMBL2181257 EC50 590.0 nM
CC1=C(C(=O)OCc2ccccc2)C(c2ccc(Cl)cc2)CC(=O)N1C CHEMBL5437459 EC50 600.0 nM
CCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccccc2)=C1C CHEMBL5425461 EC50 600.0 nM
CC[C@H]1[C@@H](O)[C@@H]2[C@H](CC[C@]3(C)[C@@H]([C@H](C)CCOS(=O)(=O)[O-])CC[C@@H]23)[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL5400252 EC50 630.0 nM
Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1cccc(F)c1 CHEMBL604752 pEC50 630.96 nM
Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1cccc(Cl)c1 CHEMBL590739 pEC50 630.96 nM
Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 CHEMBL591927 pEC50 630.96 nM
Cc1onc(-c2c(F)cccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 CHEMBL601670 pEC50 630.96 nM
CCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccccc2)=C1C CHEMBL5396796 pEC50 630.96 nM
CC[C@H]1[C@@H](O)[C@@H]2[C@H](CC[C@]3(C)[C@@H]([C@H](C)CCC(=O)[O-])[C@@H](O)C[C@@H]23)[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL2062554 EC50 650.0 nM
CC[C@@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL4646200 EC50 660.0 nM
O=C(O)CCc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 CHEMBL3290726 EC50 675.0 nM
C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C CHEMBL412272 EC50 680.0 nM
COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1F CHEMBL4075703 EC50 680.0 nM
Cc1cc(/C(CC(c2ccc(CC(=O)O)cc2)c2ccccc2C)=N/O)ccn1 CHEMBL2407953 EC50 700.0 nM
CC[C@H]1[C@@H](O)[C@@H]2[C@H](CC[C@]3(C)[C@@H]([C@H](C)CCC(=O)NS(C)(=O)=O)CC[C@@H]23)[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL4173597 EC50 700.0 nM
C#CCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccccc2)=C1C CHEMBL5394245 EC50 700.0 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccc(C(F)(F)F)cc2)=C1C CHEMBL5427795 EC50 700.0 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCC2CCCCC2)=C1C CHEMBL5439109 EC50 700.0 nM
COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccoc3)nc2c1 CHEMBL1258531 IC50 710.0 nM
CC(C)N1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 CHEMBL2181254 EC50 710.0 nM
CC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@]3(C)[C@@H]([C@H](C)CCC(=O)NCCS(=O)(=O)O)CC[C@H]3[C@H]12 CHEMBL408477 EC50 730.0 nM
CC[C@H]1[C@H](O)[C@@H]2[C@H](CC[C@]3(C)[C@@H]([C@H](C)C[C@H](C)C(=O)O)CC[C@@H]23)[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL3401356 EC50 730.0 nM
CC[C@H]1C[C@@H]2[C@H](CC[C@]3(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@@H]23)[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL3401353 EC50 750.0 nM
COc1ccc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)cc1OC CHEMBL4081476 EC50 750.0 nM
CN(c1ccc(Cl)c(Cl)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 CHEMBL4088938 EC50 750.0 nM
CC(CC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL160902 EC50 770.0 nM
COc1ccc(C2(C)CCCc3nc(SCc4c(F)cncc4F)n(-c4ccc(F)cc4)c32)cc1OC CHEMBL4059508 EC50 770.0 nM
CCC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@]3(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@H]3[C@H]12 CHEMBL405879 EC50 780.0 nM
C=CCCC[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL4637054 EC50 780.0 nM
CC(C)c1onc(-c2ccccc2Cl)c1C(=O)N(c1ccc(Cl)cc1)C(C)C CHEMBL592645 pEC50 794.33 nM
CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CCC1 CHEMBL4216520 pEC50 794.33 nM
O=C([C@@H]1C[C@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 CHEMBL4217450 pEC50 794.33 nM
O=C(CCc1ccc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)c1)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO CHEMBL4203321 pEC50 794.33 nM
C=CCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccccc2)=C1C CHEMBL5436242 pEC50 794.33 nM
C=C(C)CN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccccc2)=C1C CHEMBL5433643 pEC50 794.33 nM
CC1=C(C(=O)OCc2ccccc2)C(c2ccc(Cl)cc2)CC(=O)N1Cc1ccccc1 CHEMBL5410102 pEC50 794.33 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2cccc(C(=O)OC)c2)=C1C CHEMBL5424612 pEC50 794.33 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCCCc2ccccc2)=C1C CHEMBL5424150 pEC50 794.33 nM
CC[C@H]1[C@@H](O)[C@@H]2[C@H](C[C@H](O)[C@]3(C)[C@@H]([C@H](C)C[C@@H](C)C(=O)O)CC[C@@H]23)[C@@]2(C)CC[C@@H](O)C[C@@H]12 CHEMBL565278 EC50 820.0 nM
C[C@H](O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL269897 EC50 850.0 nM
CC(C)[C@@H]1CC[C@]2(N)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 CHEMBL4849469 EC50 867.1 nM
C[C@H](CCCO)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C CHEMBL270703 EC50 870.0 nM
COc1ccc2cc(CNCc3ccc(C)cc3)c(-c3ccsc3)nc2c1 CHEMBL1258195 IC50 880.0 nM
O=C(NCCc1ccc(Cl)cc1)C1CCCN(c2ncccn2)C1 CHEMBL3234546 EC50 880.0 nM
COc1cc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)ccc1Cl CHEMBL4073081 EC50 885.0 nM
N#CC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccco1)Cc1cnccc1-c1ccccc1F CHEMBL2435930 EC50 892.0 nM
COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(C(F)(F)F)cc2)cc1OC CHEMBL4060122 EC50 900.0 nM
CC(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 CHEMBL2435934 EC50 910.0 nM
Cc1nn(C)c(Oc2ccccc2)c1C(=O)N1CCCCC1c1cccnc1 CHEMBL2336220 EC50 920.0 nM
O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccccn2)C1 CHEMBL3234556 EC50 930.0 nM
Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)c1 CHEMBL3234560 EC50 930.0 nM
COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)NCCOCCOCCOCCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC CHEMBL4089352 EC50 930.0 nM
COc1cccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)c1 CHEMBL4063932 EC50 994.0 nM
C[C@H](CCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C CHEMBL408445 EC50 1000.0 nM
CCc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 CHEMBL599126 pEC50 1000.0 nM
Cc1ccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)cc1 CHEMBL603096 pEC50 1000.0 nM
CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CC1 CHEMBL4211549 pEC50 1000.0 nM
O=C([C@@H]1CCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 CHEMBL4210112 pEC50 1000.0 nM
C[C@@]1(C(=O)N2CCN(C3CC3)c3ccccc32)CCCN1Cc1cc(Cl)ccc1Cl CHEMBL4205745 pEC50 1000.0 nM
CCCOc1cccc(OCc2ccc3ccccc3n2)c1 CHEMBL5189181 EC50 1000.0 nM
COc1ccc(S(=O)(=O)N2CCCN(S(=O)(=O)c3ccc(OC)c(OC)c3)CC2)cc1OC CHEMBL4303545 pEC50 1000.0 nM
COCCN1C(=O)CC(c2ccc(Cl)cc2)C(C(=O)OCc2ccncc2)=C1C CHEMBL5400773 EC50 1000.0 nM