O=C(NC1CC1)c1ccc(OCCCC2CC2CCCC2CCN(c3ncc(Cl)cn3)CC2)cc1F CHEMBL1771104 EC50 0.2 nM
O=C(Cc1ccc(OCC[C@@H]2C[C@@H]2C2CCN(c3ncc(Cl)cn3)CC2)cc1F)N1CCC1 CHEMBL4104464 EC50 0.2 nM
COCc1cnc(N2CCC([C@H]3C[C@H]3CCOc3cc(F)c(CC(=O)N4CCC4)c(F)c3)CC2)nc1 CHEMBL4093284 EC50 0.2 nM
O=C(NC1CC1)c1ccc(OCCC2CC2C2CCN(c3ncc(Cl)cn3)CC2)cc1F CHEMBL1771098 EC50 0.3 nM
CCc1cnc(N2CCC([C@H]3C[C@H]3CCOc3ccc(CC(=O)N4CCC4)c(F)c3)CC2)nc1 CHEMBL4098051 EC50 0.4 nM
CC(C)(C)OC(=O)N1CCC(Sc2ncnc3c2cnn3-c2ccc(S(C)(=O)=O)cc2F)CC1 CHEMBL1773283 EC50 0.5 nM
CCOC(=O)[C@@]1(Cc2ccccc2)CCc2cnc3c(-c4ccc(C(F)(F)F)cc4)cnn3c21 CHEMBL3354778 EC50 0.5 nM
CC(C)(C)OC(=O)N1CCC(Oc2ncnc3c2[nH]c(=O)n3-c2ccc(S(C)(=O)=O)cc2F)CC1 CHEMBL1773292 EC50 0.6 nM
CC(C)OC(=O)N1[C@@H]2CC[C@@H]1CC(Oc1ncnc(Nc3ccc(S(C)(=O)=O)cc3F)c1[N+](=O)[O-])C2 CHEMBL3893596 EC50 0.6 nM
CC(C)c1noc(C2CCN(c3ncnc(Nc4ccc(S(C)(=O)=O)cc4F)c3[N+](=O)[O-])CC2)n1 CHEMBL461384 EC50 0.65 nM
CC(C)(C)OC(=O)N1CCC(Oc2ncnc3c(-c4ccc(S(C)(=O)=O)cc4)noc23)CC1 CHEMBL1773293 EC50 0.7 nM
COCc1cnc(N2CCC([C@H]3C[C@H]3CCOc3ccc(CC(=O)N4CCC4)c(F)c3)CC2)nc1 CHEMBL4077033 EC50 0.7 nM
CCS(=O)(=O)c1ccc(COC[C@@H]2C[C@@H]2C2CCN(c3nc(C(C)C)no3)CC2)c(F)c1 CHEMBL3622182 EC50 0.8 nM
O=C(Cc1ccc(OCC[C@@H]2C[C@@H]2C2CCN(c3ncc(Cl)cn3)CC2)cc1F)N1CC(O)C1 CHEMBL4080222 EC50 0.8 nM
O=C(Cc1ccc(OCC[C@@H]2C[C@@H]2C2CCN(c3ncc(Cl)cn3)CC2)cc1)N1CCC1 CHEMBL4060838 EC50 0.8 nM
CC(C)(C)OC(=O)N1CCC(Oc2ncnc3c2cnn3-c2ccc(S(C)(=O)=O)cc2F)CC1 CHEMBL1775178 EC50 0.9 nM
Cc1cc(N2CCC(C3CCN(C(=O)OC(C)(C)C)CC3)CC2)nc(C#N)n1 CHEMBL1771081 EC50 1.0 nM
CC(C)(C)OC(=O)N1C2CCC1CN(c1ncc(OCc3ccncc3C#N)cn1)C2 CHEMBL2382410 IC50 1.0 nM
C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1c1ncc(OCc2ccncc2C#N)cn1 CHEMBL2086684 IC50 1.0 nM
COCCN(C)C(=O)C(C)(Cc1ccccc1)c1ccnc2c(-c3ccc(C(F)(F)F)cc3)cnn12 CHEMBL3260536 EC50 1.0 nM
CCOC(=O)[C@](C)(Cc1ccccc1)c1c(C)cnc2c(-c3ccc(C(F)(F)F)cc3)cnn12 CHEMBL3354774 EC50 1.0 nM
CC(C)(C)OC(=O)N1CCC(Oc2ncnc3c2cnn3-c2ccc(S(C)(=O)=O)cc2)CC1 CHEMBL1775169 EC50 1.1 nM
COCc1cnc(N2CCC([C@H]3C[C@H]3COCc3ccc(-n4cnnn4)c(F)c3)CC2)nc1 CHEMBL3622179 EC50 1.1 nM
CS(=O)(=O)c1cnc(O[C@H]2CC[C@H](OC3CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC3)CC2)cn1 CHEMBL3598101 EC50 1.2 nM
CC(C)(C)OC(=O)N1C[C@@H]2CC[C@@H]1C[C@@H]2Oc1ncnc(Nc2ccc(S(C)(=O)=O)cc2F)c1[N+](=O)[O-] CHEMBL4098760 EC50 1.2 nM
CC(C)(C)OC(=O)N1[C@@H]2CC[C@@H]1CC(Nc1ncnc(Nc3ccc(C#N)cc3F)c1[N+](=O)[O-])C2 CHEMBL3912040 EC50 1.3 nM
CC(C)(C)OC(=O)N1[C@@H]2CC[C@H]1C[C@@H](Oc1ncnc(Nc3ccc(S(C)(=O)=O)cc3F)c1[N+](=O)[O-])C2 CHEMBL3084479 EC50 1.4 nM
CCOC(=O)N1[C@@H]2CC[C@@H]1CC(Oc1ncnc(Nc3ccc(S(C)(=O)=O)cc3F)c1[N+](=O)[O-])C2 CHEMBL3982536 EC50 1.4 nM
CC(C)(C)c1noc(C2CCN(c3ncnc(Nc4ccc(S(C)(=O)=O)cc4)c3[N+](=O)[O-])CC2)n1 CHEMBL518819 EC50 1.5 nM
CC(C)(C)OC(=O)N1[C@@H]2CC[C@H]1C[C@H](Nc1ncnc(Nc3ccc(S(C)(=O)=O)cc3F)c1[N+](=O)[O-])C2 CHEMBL3084483 EC50 1.5 nM
CCc1cnc(N2CCC([C@H]3C[C@H]3COCc3ccc(S(C)(=O)=O)cn3)CC2)nc1 CHEMBL3622166 EC50 1.5 nM
CC(C)(C)OC(=O)N1[C@@H]2CC[C@@H]1CC(Oc1ncnc(Nc3ccc(S(C)(=O)=O)cc3F)c1[N+](=O)[O-])C2 CHEMBL3951013 EC50 1.5 nM
CC(C)(C)OC(=O)N1[C@@H]2CC[C@@H]1CC(Nc1ncnc(Nc3ccc(S(C)(=O)=O)cc3F)c1[N+](=O)[O-])C2 CHEMBL3914281 EC50 1.5 nM
O=C(Cc1ccc(OCC[C@@H]2C[C@@H]2C2CCN(c3ncc(Cl)cn3)CC2)cc1F)N1CCCCC1 CHEMBL4070965 EC50 1.5 nM
CS(=O)(=O)c1ccc(Nc2ncnc(OC3C[C@H]4CC[C@H](C3)N4S(C)(=O)=O)c2[N+](=O)[O-])c(F)c1 CHEMBL3904015 EC50 1.6 nM
CCOc1cnc(N2CCC([C@H]3C[C@H]3COCc3ccc(S(C)(=O)=O)c(F)c3)CC2)nc1 CHEMBL3622171 EC50 1.7 nM
CC(C)c1noc(N2CCC([C@H]3C[C@H]3COCc3ccc(-n4cnnn4)cc3F)CC2)n1 CHEMBL3622168 EC50 1.7 nM
CCS(=O)(=O)c1ccc(OCC[C@@H]2C[C@@H]2C2CCN(c3nc(C(C)C)no3)CC2)c(F)c1 CHEMBL3622181 EC50 1.7 nM
Cc1cc(-c2ccc(N3CCC(c4nc(C(C)C)no4)CC3)nc2)c(C#N)cc1C#N CHEMBL4639701 EC50 1.7 nM
O=C(Cc1ccc(OCC[C@@H]2C[C@@H]2C2CCN(c3ncc(Cl)cn3)CC2)cc1)NC1CC1 CHEMBL4083676 EC50 1.8 nM
CC(C)(C)OC(=O)N1CC2CCC1CC2Nc1ncnc(Nc2ccc(S(C)(=O)=O)cc2F)c1[N+](=O)[O-] CHEMBL4078300 EC50 1.8 nM
N#Cc1cnccc1COc1cnc(N2CCN(c3noc(C(F)(F)F)n3)CC2)nc1 CHEMBL4224878 pEC50 1.995 nM
Cc1nc(C#N)cc(N2CCC(C3CCN(C(=O)OC(C)(C)C)CC3)CC2)n1 CHEMBL1771082 EC50 2.0 nM
Cc1cc(N2CCC(C3CCN(c4ncc(Cl)cn4)CC3)CC2)nc(C#N)n1 CHEMBL1771093 EC50 2.0 nM
Clc1cnc(N2CCC([C@H]3C[C@H]3CCOc3ccc(-n4ccnn4)cn3)CC2)nc1 CHEMBL1771102 EC50 2.0 nM
Cc1cnc(N2CCC([C@H]3C[C@H]3CCOc3nc(C)cc(C#N)n3)CC2)nc1 CHEMBL1771103 EC50 2.0 nM
C[C@@H]1CN(c2noc(C(F)(F)F)n2)CCN1c1ncc(OCc2ccncc2C#N)cn1 CHEMBL2086693 EC50 2.0 nM
CS(=O)(=O)N1CC=C(c2cc3c(cn2)O[C@@H](C2CCN(c4ncc(C(F)(F)F)cc4F)CC2)C3)CC1 CHEMBL2204979 EC50 2.0 nM
CCc1cnc(N2CCC(C3Cc4cc(C5CCN(S(C)(=O)=O)CC5)ncc4O3)CC2)nc1 CHEMBL2204975 EC50 2.0 nM
CCCc1cnc(N2CCC(C3Cc4c(F)c(C5=CCN(S(=O)(=O)CCC)CC5)cc(F)c4O3)CC2)nc1 CHEMBL3261136 EC50 2.0 nM
COC(=O)C1(Cc2ccccc2)CCc2cnc3c(-c4ccc(C(F)(F)F)cc4)cnn3c21 CHEMBL3354779 EC50 2.0 nM
COCCN(C)C(=O)[C@@]1(Cc2cccc(F)c2)NCc2cnc3c(-c4ccc(C(F)(F)F)cc4)cnn3c21 CHEMBL3354795 EC50 2.0 nM
[2H]C([2H])(O)c1nn2c3c(cnc2c1-c1ccc(C(F)(F)F)cc1)CN[C@]3(Cc1cccc(F)c1)C(=O)OC CHEMBL3354801 EC50 2.0 nM
OCc1nn2c3c(cnc2c1-c1ccc(C(F)(F)F)cc1)CN[C@]3(Cc1cccc(F)c1)C1CC1 CHEMBL3354804 EC50 2.0 nM
CC(C)(C)OC(=O)N1CC[C@H](N(C(=O)c2ccc(-c3cnco3)cc2)C2CC2)[C@H](F)C1 CHEMBL4113795 EC50 2.0 nM
CC(C)c1noc(N2CCC([C@H]3C[C@H]3CCOc3ccc(CC(=O)N4CCC4)c(F)c3)CC2)n1 CHEMBL4097638 EC50 2.0 nM
CCNC(=O)c1cc(F)c(-c2cc3nnn(C4CCN(c5ncc(CC)cn5)CC4)c3cn2)cc1F CHEMBL4079458 EC50 2.0 nM
COCc1cnc(N2CCC([C@H]3C[C@H]3COCc3ccc(S(C)(=O)=O)cc3F)CC2)nc1 CHEMBL3622175 EC50 2.1 nM
O=C(Cc1ccc(OCC[C@@H]2C[C@@H]2C2CCN(c3ncc(Cl)cn3)CC2)c(F)c1)N1CCC1 CHEMBL4099186 EC50 2.2 nM
CC(C)(C)OC(=O)N1[C@@H]2CC[C@H]1C[C@@H](Nc1ncnc3c(Nc4ccc(S(C)(=O)=O)cc4F)ncnc13)C2 CHEMBL4242974 EC50 2.2 nM
O=S(=O)(CCO)c1ccc(COC[C@@H]2C[C@@H]2C2CCN(c3ncc(Cl)cn3)CC2)c(F)c1 CHEMBL3622165 EC50 2.3 nM
CS(=O)(=O)c1ccc(COC[C@@H]2C[C@@H]2C2CCN(c3ncc(F)cn3)CC2)cc1F CHEMBL3622173 EC50 2.4 nM
CCc1cnc(N2CCC([C@H]3C[C@H]3COCc3ccc(S(C)(=O)=O)c(F)c3)CC2)nc1 CHEMBL3622174 EC50 2.5 nM
CC(C)(C)OC(=O)N1CCC(N(c2cc(N3CCc4cc(S(C)(=O)=O)ccc43)ncn2)C(F)(F)F)CC1 CHEMBL4875358 EC50 2.5 nM
CC(C)COC(=O)N1[C@H]2CC[C@H]1CC(Oc1ncnc(Nc3ccc(C#N)cc3Cl)c1F)C2 CHEMBL4177039 EC50 2.6 nM
CC(C)OC(=O)N1CCC(Oc2ncnc3c2cnn3-c2ccc(S(C)(=O)=O)cc2F)CC1 CHEMBL1775179 EC50 2.7 nM
CC(C)c1noc(N2CCC(N(c3cc(OC4CCN(S(C)(=O)=O)CC4)ncn3)C(F)(F)F)CC2)n1 CHEMBL4851479 EC50 2.7 nM
CCc1cnc(N2CCC(n3ncc(COc4ccc(C#N)cc4F)c3C#N)CC2)nc1 CHEMBL2204985 EC50 2.78 nM
O=S1(=O)Cc2nc(-c3cc(F)c(Cl)cc3F)nc(N3CCC(CCO)CC3)c2C1 CHEMBL2158454 EC 2.8 nM
O=c1[nH]ncn1-c1ccc(-c2ccc(N3CCNCC3)nc2)cc1 CHEMBL5266838 EC50 2.8 nM
CC(C)c1noc(N2CCC(N(c3cc(N4CCc5cc(S(C)(=O)=O)ccc54)ncn3)C(F)(F)F)CC2)n1 CHEMBL4869157 EC50 2.9 nM
Cc1c(Nc2ccc(C#N)cc2Cl)ncnc1O[C@H]1C[C@H]2CC[C@@H](C1)N2S(=O)(=O)C1CC1 CHEMBL3084389 EC50 3.0 nM
C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1c1ncc(OCc2ccc(S(C)(=O)=O)cc2F)cn1 CHEMBL2086672 EC50 3.0 nM
C[C@@]1(C2CCN(c3ncc(C(F)(F)F)cn3)CC2)Cc2cc(C3=CCN(S(C)(=O)=O)CC3)ncc2O1 CHEMBL2204978 EC50 3.0 nM
CS(=O)(=O)N1CC=C(c2cc3c(cn2)O[C@@H](C2CCN(c4ncc(C5CC5)cn4)CC2)C3)CC1 CHEMBL2204977 EC50 3.0 nM
CC(C)c1nc(N2CCN(c3ncc(OCc4ccncc4C#N)cn3)[C@H](C)C2)no1 CHEMBL2086690 IC50 3.0 nM
CC(C)(C)OC(=O)N1C2CCC1CN(c1ncc(OCc3ccc(S(C)(=O)=O)cc3)cn1)C2 CHEMBL2382409 IC50 3.0 nM
CCOC(=O)[C@](C)(Cc1ccccc1)c1c(Cl)cnc2c(-c3ccc(C(F)(F)F)cc3)cnn12 CHEMBL3354777 EC50 3.0 nM
COC(=O)[C@@]1(Cc2cccc(F)c2)CCc2cnc3c(-c4ccc(C(F)(F)F)cc4)cnn3c21 CHEMBL3354780 EC50 3.0 nM
CCOC(=O)[C@@]1(Cc2ccccc2)CCc2cnc3c(-c4ccc(Cl)cc4)cnn3c21 CHEMBL3354784 EC50 3.0 nM
COC(=O)[C@@]1(Cc2cccc(F)c2)NCc2cnc3c(-c4ccc(C(F)(F)F)cc4)cnn3c21 CHEMBL3354791 EC50 3.0 nM
CN(c1ncnc2c(-c3ccc(S(C)(=O)=O)cc3F)csc12)C1CCN(C(=O)OC(C)(C)C)CC1 CHEMBL3321835 EC50 3.0 nM
C[C@@H](OC(=O)N1CCC(O[C@H]2CC[C@H](Oc3cnc(S(C)(=O)=O)cn3)CC2)CC1)C(F)(F)F CHEMBL3598099 EC50 3.0 nM
COC(C)c1cnc(N2CCC([C@H]3C[C@H]3COCc3ccc(S(C)(=O)=O)cc3F)CC2)nc1 CHEMBL3622176 EC50 3.1 nM
CC(C)(C)OC(=O)N1CC2CCC1CC2Oc1ncnc(Nc2ccc(S(C)(=O)=O)cc2)c1[N+](=O)[O-] CHEMBL4063625 EC50 3.1 nM
CC(C)(C)OC(=O)N1CCN(C(=O)c2cn(-c3ccc(S(C)(=O)=O)cc3)nn2)CC1 CHEMBL4439483 EC50 3.12 nM
COCc1cnc(N2CCC([C@H]3C[C@H]3COCc3ccc(CC(=O)N4CCOCC4)cc3F)CC2)nc1 CHEMBL3622178 EC50 3.2 nM
CC(C)SC(=O)N1CCC(Oc2cc(N3CCc4cc(S(C)(=O)=O)ccc43)ncn2)CC1 CHEMBL4778132 EC50 3.2 nM
COCc1cnc(N2CCC([C@H]3C[C@H]3COCc3ccc(S(C)(=O)=O)c(F)c3)CC2)nc1 CHEMBL3622172 EC50 3.3 nM
CC1(OC(=O)N2CCC([C@H]3C[C@H]3CCOc3ccc(CC(=O)N4CCC4)c(F)c3)CC2)CC1 CHEMBL4062339 EC50 3.3 nM
CC(C)c1noc(C2CCN(c3ncnc(Nc4ccc(S(C)(=O)=O)c(F)c4)c3[N+](=O)[O-])CC2)n1 CHEMBL459682 EC50 3.4 nM
CCN(CC1CCN(C(=O)OC(C)C)CC1)c1ncnc2c1cnn2-c1ccc(S(C)(=O)=O)cc1F CHEMBL1773281 EC50 3.4 nM
CC(C)(C)OC(=O)N1CCC(Cc2ncnc3c2cnn3-c2ccc(S(C)(=O)=O)cc2F)CC1 CHEMBL1773287 EC50 3.4 nM
CC(C)c1noc(N2CCC(COc3ccc(-c4ccc(S(C)(=O)=O)cc4)nc3)CC2)n1 CHEMBL3187503 EC50 3.4 nM
CC(C)OC(=O)N1CCC(Oc2ncnc3c2cnn3-c2ccc(S(C)(=O)=O)cc2)CC1 CHEMBL1775171 EC50 3.5 nM
CS(=O)(=O)c1ccc(Nc2ncnc(OC3C[C@H]4CC[C@H](C3)N4S(=O)(=O)c3ccc(F)cc3)c2[N+](=O)[O-])c(F)c1 CHEMBL3946188 EC50 3.5 nM
CC1(OC(=O)N2[C@H]3CC[C@H]2CC(Oc2ncnc(Nc4ccc(C#N)cc4Cl)c2F)C3)CC1 CHEMBL4162958 EC50 3.5 nM
CC(C)(C)OC(=O)N1CCC(OC(=O)c2cn(-c3ccc(C#N)cc3F)nn2)CC1 CHEMBL4578862 EC50 3.59 nM
CC(C)(C)OC(=O)N1CCC(N(c2cc(OC3CCN(S(C)(=O)=O)CC3)ncn2)C(F)(F)F)CC1 CHEMBL4855738 EC50 3.6 nM
CC(C)(C)OC(=O)N1CCC(OC(=O)c2cn(-c3ccc(S(C)(=O)=O)cc3)nn2)CC1 CHEMBL4475130 EC50 3.67 nM
CCOC(=O)N1CCC(Oc2ncnc3c2cnn3-c2ccc(S(C)(=O)=O)cc2)CC1 CHEMBL1775170 EC50 3.8 nM
O=S1(=O)Cc2nc(-c3cc(F)c(Cl)cc3F)nc(N3CCC(CO)CC3)c2C1 CHEMBL2158452 EC 3.9 nM
CCc1cnc(N2CCC(C(C)COC(=O)N3CCc4cc(S(C)(=O)=O)cc(F)c43)CC2)nc1 CHEMBL3112602 EC50 3.9 nM
CCc1cnc(N2CCC(c3nc(COc4ccc(-n5cnnn5)cc4)cs3)CC2)nc1 CHEMBL3260505 EC50 3.9 nM
CCc1cnc(N2CCC(C(C)COC(=O)N3CCc4cc(S(C)(=O)=O)ccc43)CC2)nc1 CHEMBL5284750 EC50 3.9 nM
CS(=O)(=O)c1ccc(OCC[C@@H]2C[C@@H]2C2CCN(c3ncc(Cl)cn3)CC2)nc1 CHEMBL1771100 EC50 4.0 nM
Clc1cnc(N2CCC([C@H]3C[C@H]3CCOc3ccc(-n4ccnn4)cc3)CC2)nc1 CHEMBL1771101 EC50 4.0 nM
CN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)[C@@H]1CCN(Cc2ccc(C(F)(F)F)cc2)C[C@@H]1F CHEMBL2010851 EC50 4.0 nM
CC(C)c1nc(N2C3CCC2CN(c2ncc(OCc4ccncc4C#N)cn2)C3)no1 CHEMBL2382417 IC50 4.0 nM
COCCOC(=O)C(C)(Cc1ccccc1)c1ccnc2c(-c3ccc(Cl)cc3)cnn12 CHEMBL3260535 EC50 4.0 nM
C[C@@H]1CN(c2nnc(C(F)(F)F)o2)CCN1c1ncc(OCc2ccc(OS(C)(=O)=O)cc2F)cn1 CHEMBL3358002 EC50 4.0 nM
C[C@@H]1CN(C(=O)OC2(C(F)(F)F)COC2)CCN1c1ncc(OCc2ccc(OS(C)(=O)=O)cc2F)cn1 CHEMBL3358011 EC50 4.0 nM
C[C@@H]1CN(c2nc(C(F)(F)F)no2)CCN1c1ncc(OCc2ccc(S(C)(=O)=O)cc2F)cn1 CHEMBL3358005 EC50 4.0 nM
Cc1c(Nc2ccc(C#N)cc2Cl)ncnc1OC1C2COCC1CN(C(=O)OC1(C)CC1)C2 CHEMBL3629484 EC50 4.0 nM
CCc1cnc(N2CCC(n3ncc4cc(-c5ccc(S(C)(=O)=O)cc5F)ncc43)CC2)nc1 CHEMBL3823780 EC50 4.0 nM
CN(C)C(=O)c1ccc(OCCCCC[C@H]2CC[C@]3(CC2)COC(C)(C)C3)cc1 CHEMBL4205617 EC50 4.0 nM
CN(C)C(=O)c1ccc(OCCCCC[C@H]2CC[C@@]3(CC2)CC(C)(C)CO3)cc1 CHEMBL4203148 EC50 4.0 nM
CCc1cnc(N2CCC(n3ncc4ccc(-c5ccc(S(C)(=O)=O)cc5F)nc43)CC2)cn1 CHEMBL5179691 EC50 4.0 nM
CC(C)COC(=O)N1CCC(Oc2ncnc3c2cnn3-c2ccc(S(C)(=O)=O)cc2)CC1 CHEMBL1775173 EC50 4.2 nM
CC(C)c1noc(N2CCC([C@H]3C[C@H]3COCc3ccc(S(C)(=O)=O)cc3F)CC2)n1 CHEMBL3622167 EC50 4.2 nM
CC(C)(C)OC(=O)N1CCN(C(=O)c2cn(-c3ccc(C#N)cc3F)nn2)CC1 CHEMBL4435207 EC50 4.21 nM
COCc1cnc(N2CCC([C@H]3C[C@H]3COCc3cc(F)c(S(C)(=O)=O)c(F)c3)CC2)nc1 CHEMBL3622180 EC50 4.5 nM
COc1cnc(N2CCC([C@H]3C[C@H]3COCc3ccc(S(C)(=O)=O)cc3F)CC2)nc1 CHEMBL3622170 EC50 4.5 nM
CC(C)(F)c1noc(N2CCC(N(c3cc(OC4CCN(S(C)(=O)=O)CC4)ncn3)C(F)(F)F)CC2)n1 CHEMBL4870635 EC50 4.6 nM
CCCS(=O)(=O)c1ccc(Nc2ncnc(N3CCC(c4nc(C(C)C)no4)CC3)c2[N+](=O)[O-])cc1 CHEMBL461558 EC50 4.7 nM
CCc1cnc(C(=O)N2CCC(Oc3ncnc(Oc4ccc(S(C)(=O)=O)nc4C)c3F)CC2)nc1 CHEMBL3326688 EC50 4.7 nM
C[C@H](OC(=O)N1CCC(O[C@H]2CC[C@H](Oc3cnc(S(C)(=O)=O)cn3)CC2)CC1)C(F)(F)F CHEMBL3598100 EC50 4.8 nM
CC1(OC(=O)N2CCC([C@H]3C[C@H]3COCc3ccc(-n4cnnn4)cc3F)CC2)CC1 CHEMBL3622169 EC50 4.8 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)SC(C)(C)C)CC2)c1F CHEMBL3326673 EC50 4.83 nM
CC(C)(C)OC(=O)N1[C@@H]2CC[C@H]1C[C@@H](Oc1ncnc(Nc3ccc(S(C)(=O)=O)cc3)c1[N+](=O)[O-])C2 CHEMBL3084480 EC50 4.9 nM
CC(C)(C)OC(=O)N1CC2CC1CC2Nc1ncnc(Nc2ccc(S(C)(=O)=O)cc2F)c1[N+](=O)[O-] CHEMBL4065265 EC50 4.9 nM
CCc1cnc(N2CC=C(c3nc(COc4ccc(-n5cnnn5)cc4)cs3)CC2)nc1 CHEMBL4648870 EC50 4.9 nM
CS(=O)(=O)c1ccc(N2CCC(C3CCN(c4ncc(Cl)cn4)CC3)CC2)cc1 CHEMBL1770161 EC50 5.0 nM
C[C@@H]1CN(c2nc(C(F)(F)F)no2)CCN1c1ncc(OCc2ccncc2C#N)cn1 CHEMBL2087086 EC50 5.0 nM
CCCc1cnc(N2CCC(C3Cc4c(ccc(C5=CCN(S(=O)(=O)CCC)CC5)c4F)O3)CC2)nc1 CHEMBL3261134 EC50 5.0 nM
COC(=O)[C@@]1(Cc2cccc(F)c2)NCc2cnc3c(-c4ccc(C(F)(F)F)cc4)c(CO)nn3c21 CHEMBL3354798 EC50 5.0 nM
CCCc1cnc(N2CCC(Oc3cc(=O)n(-c4ccc(S(C)(=O)=O)cc4)cc3Cl)CC2)nc1 CHEMBL3338188 EC50 5.0 nM
COc1c(Nc2ccc(C#N)cc2F)ncnc1OC1C2COCC1CN(C(=O)OC1(C)CC1)C2 CHEMBL3629597 EC50 5.0 nM
CN(C)C(=O)c1ccc(OCCCCCC2CCN(C(=O)OC(C)(C)C)CC2)cc1 CHEMBL4208239 EC50 5.0 nM
CC1(C)C[C@]2(CC[C@H](Oc3ncnc4c3CCN4c3ccc(S(C)(=O)=O)cc3F)CC2)CO1 CHEMBL4582928 EC50 5.0 nM
C[C@@H](O[C@H]1CC[C@]2(CC1)COC(C)(C)C2)c1nc(-c2cc(F)c(CS(C)(=O)=O)c(F)c2)no1 CHEMBL4466171 EC50 5.0 nM
CC(C)(C)OC(=O)N1CCN(c2ncc(OCc3ccncc3C#N)cn2)CC1 CHEMBL2086680 EC50 5.0 nM
N#Cc1cnccc1COc1cnc(N2CCN(c3nc(C(F)(F)F)no3)CC2)nc1 CHEMBL4225726 pEC50 5.012 nM
CC(C)c1noc(C2CCN(c3ncnc(Nc4ccc(S(C)(=O)=O)cc4)c3[N+](=O)[O-])CC2)n1 CHEMBL462196 EC50 5.1 nM
CC1(OC(=O)N2[C@H]3CC[C@H]2CC(Oc2ncnc(Nc4ccc(C#N)cc4Cl)c2F)C3)CCC1 CHEMBL4173664 EC50 5.1 nM
CCC(F)(F)C(=O)N1CCC(O[C@H]2CC[C@H](Oc3cnc(S(C)(=O)=O)cn3)CC2)CC1 CHEMBL3598104 EC50 5.3 nM
CCc1cnc(N2CCC(n3ncc(COc4ccc(-n5cnnn5)cc4)c3C#N)CC2)nc1 CHEMBL2204984 EC50 5.32 nM
Cc1ccc(Oc2ncnc(OC3CCN(C(=O)OC(C)C)CC3)c2C)c(C)n1 CHEMBL1949674 EC50 5.4 nM
CS(=O)(=O)N1CCC(Oc2cc(N(C3CCN(c4nc(C5CC5)no4)CC3)C(F)(F)F)ncn2)CC1 CHEMBL4846307 EC50 5.4 nM
CC(C)(C)OC(=O)N1CCC(Sc2ncnc3c2cnn3-c2ccc(S(C)(=O)=O)cc2)CC1 CHEMBL1773282 EC50 5.6 nM
CC(C)(C)OC(=O)N1CC2CC1CC2Oc1ncnc(Nc2ccc(S(C)(=O)=O)cc2F)c1[N+](=O)[O-] CHEMBL4067982 EC50 5.6 nM
CC(C)(C)OC(=O)N1CC2CCC1CC2Nc1ncnc(Nc2ccc(S(C)(=O)=O)cc2)c1[N+](=O)[O-] CHEMBL4062726 EC50 5.6 nM
CC(C)(C)OC(=O)N1CCC(O[C@H]2CC[C@H](Oc3cnc(S(C)(=O)=O)cn3)CC2)CC1 CHEMBL3598090 EC50 5.9 nM
CC(C)(C)OC(=O)N1CCC(C2CCN(c3ccnc(C#N)n3)CC2)CC1 CHEMBL1771079 EC50 6.0 nM
CC(C)(C)OC(=O)N1CCC(C2CCN(c3cc(C#N)ncn3)CC2)CC1 CHEMBL1771080 EC50 6.0 nM
C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1c1ncc(OCc2ccc(-n3cnnn3)cc2)cn1 CHEMBL2086671 EC50 6.0 nM
C[C@@H]1CN(C(=O)OC2CC(F)(F)C2(F)F)CCN1c1ncc(OCc2ccncc2C#N)cn1 CHEMBL2382412 EC50 6.0 nM
OCc1nn2c3c(cnc2c1-c1ccc(C(F)(F)F)nc1)CN[C@]3(Cc1cccc(F)c1)C1CC1 CHEMBL3354805 EC50 6.0 nM
CC(C)c1noc(N2CCN(c3ncc(OCc4ccc(S(C)(=O)=O)cc4F)cn3)[C@H](C)C2)n1 CHEMBL3358014 EC50 6.0 nM
CC1(OC(=O)N2C[C@H]3COC[C@@H](C2)[C@@H]3Oc2ncnc(Nc3ccccc3F)c2F)CC1 CHEMBL4161243 EC50 6.0 nM
CCC1(OC(=O)N2CC3COCC(C2)C3Oc2ncnc(Nc3ccc(C#N)cc3F)c2F)CC1 CHEMBL4167676 EC50 6.0 nM
C[C@@H](O[C@H]1CC[C@]2(CCC(F)(F)CO2)CC1)c1nc(-c2cc(F)c(CS(C)(=O)=O)c(F)c2)no1 CHEMBL4548931 EC50 6.0 nM
CC(C)c1nc(N2CCN(c3ncc(OCc4ccncc4C#N)cn3)CC2)no1 CHEMBL2382416 EC50 6.0 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)c3ncc(Cl)cn3)CC2)c1F CHEMBL3326689 EC50 6.12 nM
CC(C)OC(=O)N1[C@@H]2CC[C@@H]1CC(Nc1ncnc(Nc3ccc(S(C)(=O)=O)cc3F)c1[N+](=O)[O-])C2 CHEMBL3930728 EC50 6.2 nM
CCN(CC1CCN(C(=O)OC(C)(C)C)CC1)c1ncnc2c1cnn2-c1ccc(S(C)(=O)=O)cc1 CHEMBL1773280 EC50 6.3 nM
CC(C)(C)OC(=O)N1CCC(CO[C@H]2CC[C@H](c3ccc(S(C)(=O)=O)cc3F)CC2)CC1 CHEMBL2323599 EC50 6.4 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)OC(C)(C)C(F)(F)F)CC2)c1F CHEMBL3325846 EC50 6.53 nM
CC(C)(C)OC(=O)N1[C@@H]2CC[C@H]1C[C@@H](CNc1ncnc(Nc3ccc(S(C)(=O)=O)cc3F)c1[N+](=O)[O-])C2 CHEMBL3084481 EC50 6.7 nM
CC(COC(=O)N1CCc2cc(S(C)(=O)=O)cc(F)c21)C1CCN(C(=O)OC(C)(C)C)CC1 CHEMBL3113837 EC50 6.8 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)SC(C)C)CC2)c1F CHEMBL3326672 EC50 6.8 nM
CCS(=O)(=O)c1ccc(Nc2ncnc(N3CCC(c4nc(C(C)C)no4)CC3)c2[N+](=O)[O-])c(F)c1 CHEMBL461385 EC50 7.0 nM
Cc1c(Oc2ccccc2C#N)ncnc1O[C@H]1C[C@H]2CC[C@@H](C1)N2S(=O)(=O)C1CC1 CHEMBL3084383 EC50 7.0 nM
CN(C(=O)Cc1ccc(-n2cnnn2)cc1)[C@@H]1CCN(Cc2ccc(C(F)(F)F)cc2)C[C@@H]1F CHEMBL2010845 EC50 7.0 nM
Cc1c(Oc2ccc(-n3cnnn3)cc2F)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C CHEMBL2312159 Ki 7.0 nM
N#Cc1cnccc1COc1cnc(N2CC3CCC(C2)N3C(=O)OC2CC(F)(F)C2(F)F)nc1 CHEMBL2382413 EC50 7.0 nM
COC(=O)C1(Cc2ccccc2)CCc2cnc3c(-c4ccc(C#N)cc4)cnn3c21 CHEMBL3354786 EC50 7.0 nM
C[C@@H]1CN(c2nnc(C(F)(F)F)o2)CCN1c1ncc(OCc2ccc(-n3cnnn3)cc2F)cn1 CHEMBL3358000 EC50 7.0 nM
Cc1c(Nc2ccc(C#N)cc2Cl)ncnc1OC1C2COCC1CN(C(=O)OC(C)(C)C)C2 CHEMBL3629481 EC50 7.0 nM
COc1c(Nc2ccc(C#N)cc2Cl)ncnc1OC1C2COCC1CN(C(=O)OC1(C)CC1)C2 CHEMBL3629485 EC50 7.0 nM
C[C@H]1CN(C(=O)OC(C)(C)C)CC[C@H]1N(C(=O)c1ccc(-c2cnco2)cc1)C1CC1 CHEMBL3909707 EC50 7.0 nM
CCc1cnc(N2CCC(n3nnc4cc(-c5ccc(S(C)(=O)=O)cc5F)ncc43)CC2)nc1 CHEMBL4095963 EC50 7.0 nM
CN(C)C(=O)c1ccc(OCCCCC[C@H]2CC[C@@]3(CC2)CC(C)(C)CCO3)cc1 CHEMBL4213027 EC50 7.0 nM
C[C@@H](O[C@H]1CC[C@@]2(CC1)CC(F)(F)CO2)c1nc(-c2cc(F)c(CS(C)(=O)=O)c(F)c2)no1 CHEMBL4450117 EC50 7.0 nM
CCS(=O)(=O)c1ccc(COC[C@@H]2C[C@@H]2C2CCN(c3ncc(COC)cn3)CC2)c(F)c1 CHEMBL3622177 EC50 7.1 nM
CC(C)(C)OC(=O)N1CCN(C(=O)c2cn(-c3nc4ccccc4s3)nn2)CC1 CHEMBL4457078 EC50 7.12 nM
CC(C)(C)OC(=O)N1CCC(Cc2ncnc3c2cnn3-c2ccc(S(C)(=O)=O)cc2)CC1 CHEMBL1773286 EC50 7.3 nM
Cc1ncccc1Oc1ncnc(OC2CCN(C(=O)OC(C)C)CC2)c1C CHEMBL1766081 EC50 7.3 nM
CC(C)(C)OC(=O)N1CCC(Oc2ncnc3c2nnn3-c2ccc(S(C)(=O)=O)cc2)CC1 CHEMBL1773291 EC50 7.4 nM
CCCCOC(=O)N1CCC(Oc2ncnc3c2cnn3-c2ccc(S(C)(=O)=O)cc2)CC1 CHEMBL1775172 EC50 7.5 nM
CC(C)c1noc(N2CCC(Oc3cc(N4CCc5cc(S(C)(=O)=O)ccc54)ncn3)CC2)n1 CHEMBL3113623 EC50 7.7 nM
CC(C)c1noc(C2CCN(c3ncnc(Nc4ccc(S(=O)(=O)C(C)C)cc4)c3[N+](=O)[O-])CC2)n1 CHEMBL461747 EC50 7.8 nM
CC(C)c1noc(C2CCN(c3ncnc(Nc4ccc(S(=O)(=O)C(C)C)cc4F)c3[N+](=O)[O-])CC2)n1 CHEMBL461560 EC50 7.9 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)OC(C)(C)C)CC2)c1F CHEMBL3325844 EC50 7.91 nM
Cc1cnc(N2CCC(C3CCN(c4cc(C#N)nc(C)n4)CC3)CC2)nc1 CHEMBL1771094 EC50 8.0 nM
N#Cc1cnccc1COc1cnc(N2CC3CCC(C2)N3C(=O)OCC(F)(F)F)nc1 CHEMBL2382415 IC50 8.0 nM
CCOC(=O)[C@@]1(Cc2ccccc2)CCCc2cnc3c(-c4ccc(C(F)(F)F)cc4)cnn3c21 CHEMBL3354781 EC50 8.0 nM
C[C@@H]1CN(c2nc(C(F)(F)F)no2)CCN1c1ncc(OCc2ccc(C[S+](C)[O-])cc2F)cn1 CHEMBL3358007 EC50 8.0 nM
CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3cnco3)c(F)c2)C2CC2)CC1 CHEMBL3969850 EC50 8.0 nM
CC(C)OC(=O)N1[C@H]2CC[C@H]1CC(Oc1ncnc(Nc3ccc(C#N)cc3Cl)c1F)C2 CHEMBL4164666 EC50 8.0 nM
CC(C)OC(=O)N1CCC2(CC1)CC(CCCOc1ccc(C(=O)NC3CC3)c(F)c1)C2 CHEMBL4228249 EC50 8.0 nM
CC(C)(C)COC(=O)N1CCC(Oc2ncnc3c2cnn3-c2ccc(S(C)(=O)=O)cc2)CC1 CHEMBL1775176 EC50 8.1 nM
CC(C)(C)OC(=O)N1[C@@H]2CC[C@H]1C[C@@H](Nc1ncnc3c(Nc4ccc(C#N)cc4F)ncnc13)C2 CHEMBL4248331 EC50 8.1 nM
CC(C)(C)OC(=O)N1CCC(OC(=O)c2cn(-c3nc4ccccc4s3)nn2)CC1 CHEMBL4521163 EC50 8.17 nM
NC(=O)CC1CCN(c2nc(-c3cc(F)c(Cl)cc3F)nc3c2CS(=O)(=O)C3)CC1 CHEMBL2158453 EC 8.3 nM
CC(C)(C)OC(=O)N1CCC(O[C@H]2CC[C@H](Oc3cnc(C#N)cn3)CC2)CC1 CHEMBL3598092 EC50 8.3 nM
CC(COC(=O)N1CCc2cc(S(C)(=O)=O)ccc21)C1CCN(C(=O)OC(C)(C)C)CC1 CHEMBL3113629 EC50 8.4 nM
CC(C)(C)OC(=O)N1CCC(O[C@H]2CC[C@H](Oc3ccc(S(C)(=O)=O)cc3F)CC2)CC1 CHEMBL3598083 EC50 8.5 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)SC3CCC3)CC2)c1F CHEMBL3326676 EC50 8.51 nM
CC(C)(C)OC(=O)N1CCC(O[C@H]2CC[C@H](Oc3ccc(C#N)cc3)CC2)CC1 CHEMBL3598085 EC50 8.6 nM
CS(=O)(=O)c1ccc(COC[C@@H]2C[C@@H]2C2CCN(c3ncc(Cl)cn3)CC2)nc1 CHEMBL3622164 EC50 8.7 nM
CC(C)(C)OC(=O)N1CCN(C(=O)c2cn(-c3ccc(C(F)(F)F)cc3Cl)nn2)CC1 CHEMBL4445174 EC50 8.78 nM
CCc1cnc(N2CC=C(c3nc(COc4ccc(-n5cnnn5)cc4F)cs3)CC2)nc1 CHEMBL4647675 EC50 8.8 nM
O=C(NC1CC1)c1ccc(OCC2CC2CC2CCN(c3ncc(Cl)cn3)CC2)cc1F CHEMBL1771099 EC50 9.0 nM
Cc1cc2c(c(Oc3ccc(C)c(NS(=O)(=O)c4ccc(Cl)cc4)c3)n1)C(=O)N(C(C)C)C2=O CHEMBL3104881 EC50 9.0 nM
CCCc1cnc(N2CCC(Oc3ccn(-c4ccc(S(C)(=O)=O)c(F)c4)c(=O)c3)CC2)nc1 CHEMBL3338182 EC50 9.0 nM
CC(C)(C)OC(=O)N1CCC(c2cc3cc(C4=CCN(S(C)(=O)=O)CC4)ncc3o2)CC1 CHEMBL3717448 EC50 9.0 nM
CC(C)(C)OC(=O)N1CCC(c2cc3cc(-c4ccc(S(C)(=O)=O)cc4F)ncc3o2)CC1 CHEMBL3719203 EC50 9.0 nM
CC(C)(C)OC(=O)N1CCC(N(C(=O)c2cc(F)c(-c3cnco3)c(F)c2)C2CC2)CC1 CHEMBL3970904 EC50 9.0 nM
CCc1cnc(N2CCC(n3nnc4cc(-c5ccc(S(C)(=O)=O)c(F)c5)ncc43)CC2)nc1 CHEMBL4068645 EC50 9.0 nM
CC(C)(C)OC(=O)N1CCC2(CC1)CC(CCCOc1ccc(S(C)(=O)=O)c(F)c1)C2 CHEMBL4225084 EC50 9.0 nM
CC(C)c1nc(CN2CCC(O[C@H]3CC[C@H](Oc4cnc(S(C)(=O)=O)cn4)CC3)CC2)no1 CHEMBL3598113 EC50 9.1 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)O[C@H](C)C(F)(F)F)CC2)c1F CHEMBL3325852 EC50 9.2 nM
O=C(Cc1ccc(OCC[C@@H]2C[C@@H]2C2CCN(c3ncc(Cl)cn3)CC2)nc1)N1CCC1 CHEMBL4081159 EC50 9.4 nM
CS(=O)(=O)c1cnc(O[C@H]2CC[C@H](OC3CCN(C(=O)Oc4ccccc4)CC3)CC2)cn1 CHEMBL3598103 EC50 9.6 nM
Cc1c(Oc2ccc(S(C)(=O)=O)cc2F)ncnc1OC1CCN(C(=O)OC(C)C)CC1 CHEMBL1951011 EC50 9.7 nM
CC(C)c1noc(N2CCC(Oc3cc(N4CCc5cc(N6CCCS6(=O)=O)ccc54)ncn3)CC2)n1 CHEMBL4760572 EC50 9.7 nM
CC(C)SC(=O)N1CCC(Oc2cc(N3CCc4cc([S+]([O-])CCO)ccc43)ncn2)CC1 CHEMBL4757058 EC50 9.7 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)O[C@@H](C)C(F)(F)F)CC2)c1F CHEMBL3326666 EC50 9.86 nM
CCc1noc(C2CCN(c3ncnc(Nc4ccc(S(C)(=O)=O)cc4)c3[N+](=O)[O-])CC2)n1 CHEMBL451793 EC50 10.0 nM
CC(C)c1noc(N2CCN(c3ncc(OCc4ccncc4C#N)cn3)[C@H](C)C2)n1 CHEMBL2087084 EC50 10.0 nM
CC(C)SC(=O)N1CCC(Oc2ncnc3c2CCN3c2ccc(S(C)(=O)=O)cc2F)CC1 CHEMBL2177762 pEC50 10.0 nM
CCOC(=O)[C@](C)(Cc1ccccc1)c1ccnc2c(-c3ccc(C(F)(F)F)cc3)cnn12 CHEMBL3260533 EC50 10.0 nM
C[C@@H]1CN(c2nnc(C(F)(F)F)o2)CCN1c1ncc(OCc2ccc(C#N)cc2C#N)cn1 CHEMBL3357996 EC50 10.0 nM
CC1(OC(=O)N2CCC(c3cc4cc(C5=CCN(S(C)(=O)=O)CC5)ncc4o3)CC2)CC1 CHEMBL3717304 EC50 10.0 nM
CC(C)(OC(=O)N1CCC(n2ncc3cc(-c4ccc(S(C)(=O)=O)cc4F)ncc32)CC1)C(F)F CHEMBL3823396 EC50 10.0 nM
CCNC(=O)c1cc(F)c(-c2cc3cnn(C4CCN(C(=O)OC(C)C)CC4)c3cn2)cc1F CHEMBL3824019 EC50 10.0 nM
CC(C)(OC(=O)N1CCC(N(C(=O)c2ccc(-c3cnco3)cc2)C2CC2)CC1)C(F)(F)F CHEMBL3903582 EC50 10.0 nM
CCNC(=O)c1ccc(-c2cc3nnn(C4CCN(c5ncc(CC)cn5)CC4)c3cn2)c(F)c1F CHEMBL4065926 EC50 10.0 nM
CC1(OC(=O)N2C[C@H]3COC[C@@H](C2)[C@@H]3Oc2ncnc(Nc3ccc(C#N)cc3Cl)c2F)CC1 CHEMBL4159767 EC50 10.0 nM
N#Cc1ccc(Nc2ncnc(OC3C4COCC3CN(C(=O)OC3CCC3)C4)c2F)c(Cl)c1 CHEMBL4163003 EC50 10.0 nM
CC1(OC(=O)N2CC3COCC(C2)C3Oc2ncnc(Nc3ccc(C#N)cc3Cl)c2F)CCC1 CHEMBL4173709 EC50 10.0 nM
CC(C)OC(=O)N1CCC(CCCCCOc2ccc(C(=O)N(C)C)cc2)CC1 CHEMBL4215560 EC50 10.0 nM
CCc1cnc(N2CC=C(c3nc(COc4ccc(-n5cnnn5)cc4Cl)cs3)CC2)nc1 CHEMBL4641634 EC50 10.2 nM
CC(C)(C)OC(=O)N1CCC(OC(=O)c2cn(-c3ccc(C(F)(F)F)cc3)nn2)CC1 CHEMBL4591642 EC50 10.43 nM
CC(F)Cc1noc(CN2CCC(O[C@H]3CC[C@H](Oc4cnc(S(C)(=O)=O)cn4)CC3)CC2)n1 CHEMBL3598114 EC50 10.7 nM
C[S+]([O-])c1ccc(N2CCC(C3CCN(C(=O)OC(C)(C)C)CC3)CC2)cc1 CHEMBL1771070 EC50 11.0 nM
Cc1cc2c(c(Oc3cccc(N(C)S(=O)(=O)c4ccc(Cl)cc4)c3)n1)C(=O)N(C(C)C)C2=O CHEMBL3104882 EC50 11.0 nM
CCN1C(=O)c2cc(C)nc(Oc3cccc(NS(=O)(=O)c4ccc(Cl)cc4)c3)c2C1=O CHEMBL3104892 EC50 11.0 nM
CCc1cnc(N2CCC(Oc3cc(N4CCc5cc(S(C)(=O)=O)ccc54)ncn3)CC2)nc1 CHEMBL3113622 EC50 11.0 nM
CCOC(=O)C(C)(Cc1ccccc1)c1ccnc2c(-c3ccc(C(F)(F)F)cc3)cnn12 CHEMBL3260532 EC50 11.0 nM
COC(=O)C1(Cc2ccccc2)COc2cnc3c(-c4ccc(C(F)(F)F)cc4)cnn3c21 CHEMBL3354788 EC50 11.0 nM
C[C@@H]1CN(c2nc(C(F)(F)F)no2)CCN1c1ncc(OCc2ccc(CS(C)(=O)=O)cc2F)cn1 CHEMBL3358006 EC50 11.0 nM
CCCc1cnc(N2CCC(Oc3ccn(-c4ccc(C#N)cc4)c(=O)c3)CC2)nc1 CHEMBL3338176 EC50 11.0 nM
Cc1nc(S(C)(=O)=O)ccc1O[C@H]1CC[C@H](OC2CCN(C(=O)OC(C)C)CC2)CC1 CHEMBL3598088 EC50 11.0 nM
CC(C)COC(=O)N1CCC(n2ncc3cc(-c4ccc(S(C)(=O)=O)cc4)ncc32)CC1 CHEMBL3822762 EC50 11.0 nM
CC(C)(C)OC(=O)N1CCC(OC(=O)c2cn(-c3ccc(C(F)(F)F)cc3Cl)nn2)CC1 CHEMBL4473081 EC50 11.12 nM
CC(C)(C)OC(=O)N1[C@@H]2CC[C@H]1C[C@H](Nc1ncnc(Nc3ccc(S(C)(=O)=O)cc3)c1[N+](=O)[O-])C2 CHEMBL3084484 EC50 11.5 nM
CN(CC1CCN(C(=O)OC(C)(C)C)CC1)c1ncnc2c1cnn2-c1ccc(S(C)(=O)=O)cc1 CHEMBL1773279 EC50 11.6 nM
CN(C(=O)Cc1ccc(-n2cnnn2)cc1)[C@@H]1CCN(Cc2nc3cc(F)ccc3s2)C[C@@H]1F CHEMBL2010850 EC50 12.0 nM
C[C@@H]1CN(C(=O)OC2(C(F)(F)F)COC2)CCN1c1ncc(OCc2ccc(S(C)(=O)=O)cc2F)cn1 CHEMBL3358012 EC50 12.0 nM
CCCc1cnc(N2CCC(Oc3cc(=O)n(-c4ccc(S(C)(=O)=O)cc4)cc3C#N)CC2)nc1 CHEMBL3338187 EC50 12.0 nM
CS(=O)(=O)c1ccc(-n2cc(Cl)c(OC3CCN(c4ncc(C(F)(F)F)cn4)CC3)cc2=O)c(F)c1 CHEMBL3338190 EC50 12.0 nM
CC(C)OC(=O)N1CCC(c2cc3cc(-c4ccc(S(C)(=O)=O)cc4F)ncc3o2)CC1 CHEMBL3717176 EC50 12.0 nM
COC(=O)C1CN(c2ccc(N3CC[C@@H](Oc4ccc(OCC(F)(F)F)nc4)C3=O)cn2)C1 CHEMBL4584670 EC50 12.0 nM
CC(C)(C)OC(=O)N1CCC(OC(=O)c2cn(-c3ccc(Cl)c(C(F)(F)F)c3)nn2)CC1 CHEMBL4461083 EC50 12.31 nM
CC(C)(C)OC(=O)N1CCN(C(=O)c2cn(-c3ccc(Cl)c(C(F)(F)F)c3)nn2)CC1 CHEMBL4456666 EC50 12.34 nM
CC(C)(C)OC(=O)N1CCN(C(=O)c2cn(-c3ccc(S(C)(=O)=O)cc3F)nn2)CC1 CHEMBL4461803 EC50 12.43 nM
CS(=O)(=O)c1ccc(N2CCc3c(OC4CCN(C(=S)Sc5ccccc5)CC4)ncnc32)c(F)c1 CHEMBL2177763 pEC50 12.59 nM
CC(CNC(=O)Cc1c(F)ccc(F)c1F)C1CCN(C(=O)OC(C)(C)C)CC1 CHEMBL1683944 EC50 13.0 nM
CS(=O)(=O)c1ccc(N2CCC(C3CCN(c4ccc(C(F)(F)F)cn4)CC3)CC2)cc1 CHEMBL1771092 EC50 13.0 nM
CCOC(=O)c1cc(C)nc(Oc2cccc(NS(=O)(=O)c3ccc(Cl)cc3)c2)c1C#N CHEMBL2391429 EC50 13.0 nM
Cc1cc2c(c(Oc3cccc(NS(=O)(=O)c4ccc(Cl)cc4)c3)n1)C(=O)N(C(C)C)C2=O CHEMBL3104893 EC50 13.0 nM
CS(=O)(=O)c1ccc(-n2cc(Cl)c(OC3CCN(c4ncc(C(F)(F)F)cn4)CC3)cc2=O)cc1 CHEMBL3338189 EC50 13.0 nM
CS(=O)(=O)c1ccc(-n2cc(Cl)c(OC3CCN(c4ncc(Cl)cn4)CC3)cc2=O)cc1F CHEMBL3338193 EC50 13.0 nM
CC(C)OC(=O)N1CCC(O[C@H]2CC[C@H](Oc3ccc(S(C)(=O)=O)nc3)CC2)CC1 CHEMBL3598087 EC50 13.0 nM
CC1(OC(=O)N2CCC(c3cc4cc(-c5ccc(S(C)(=O)=O)cc5F)ncc4o3)CC2)CC1 CHEMBL3716002 EC50 13.0 nM
CCc1cnc(N2CCC(n3ncc4cc(-c5ccc(S(C)(=O)=O)cc5)ncc43)CC2)nc1 CHEMBL3824187 EC50 13.0 nM
CCNC(=O)c1ccc(-c2cc3nnn(C4CCN(c5ncc(CC)cn5)CC4)c3cn2)c(Cl)c1 CHEMBL4099323 EC50 13.0 nM
CC1(OC(=O)N2C[C@H]3COC[C@@H](C2)[C@@H]3Oc2ncnc(Nc3c(F)cccc3F)c2F)CC1 CHEMBL4169168 EC50 13.0 nM
CC1(OC(=O)N2CCC3(CC2)CC(CCCOc2ccc(S(C)(=O)=O)c(F)c2)C3)CC1 CHEMBL4225663 EC50 13.0 nM
Cc1c(Nc2ccc(S(C)(=O)=O)cc2F)ncnc1O[C@H]1CC[C@]2(CC1)COC(C)(C)C2 CHEMBL4470443 EC50 13.0 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)SC3(C)CC3)CC2)c1F CHEMBL3326675 EC50 13.2 nM
CC(C)(C)OC(=O)N1CCN(C(=O)c2cn(-c3ccc(C(F)(F)F)cc3)nn2)CC1 CHEMBL4464713 EC50 13.56 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)OC3CCC3)CC2)c1F CHEMBL3325845 EC50 13.6 nM
CC(C)OC(=O)N1CCC(O[C@H]2CC[C@H](Oc3cnc(S(C)(=O)=O)cn3)CC2)CC1 CHEMBL3598094 EC50 13.7 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)OC3(C)CC3)CC2)c1F CHEMBL3326667 EC50 13.8 nM
CC(C)(C)OC(=O)N1CCC(OC(=O)c2cn(-c3ccc(S(C)(=O)=O)cc3F)nn2)CC1 CHEMBL4454792 EC50 13.98 nM
CC(C)OC(=O)N1CCC(Oc2ncnc3c(-c4ccc(S(C)(=O)=O)cc4)noc23)CC1 CHEMBL1773294 EC50 14.0 nM
C[C@@H]1CN(c2noc(C3CC3)n2)CCN1c1ncc(OCc2ccncc2C#N)cn1 CHEMBL2086691 EC50 14.0 nM
O=S1(=O)Cc2nc(-c3cc(F)c(Cl)cc3F)nc(N3CCC(O)CC3)c2C1 CHEMBL2158447 EC 14.0 nM
CCCS(=O)(=O)N1CC=C(c2ccc3c(c2)CC(C2CCN(c4ncc(C(F)(F)F)cn4)CC2)O3)CC1 CHEMBL3261127 EC50 14.0 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)c3noc(C(C)(C)F)n3)CC2)c1F CHEMBL3326686 EC50 14.0 nM
CS(=O)(=O)c1ccc(-n2cc(Cl)c(OC3CCN(c4ncc(Cl)cn4)CC3)cc2=O)c(F)c1 CHEMBL3338194 EC50 14.0 nM
CC(C)c1noc(CN2CCC(O[C@H]3CC[C@H](Oc4cnc(S(C)(=O)=O)cn4)CC3)CC2)n1 CHEMBL3598112 EC50 14.0 nM
CCc1cnc(N2CCC(C(C)CCNc3cc4c(cn3)C(=O)CO4)CC2)nc1 CHEMBL3809686 EC50 14.0 nM
CCCNC(=O)c1cc(F)c(-c2cc3cnn(C4CCN(C(=O)OC(C)C)CC4)c3cn2)cc1F CHEMBL3824111 EC50 14.0 nM
CCc1cnc(N2CCC(n3ncc4cc(-c5ccc(S(C)(=O)=O)cc5)ccc43)CC2)nc1 CHEMBL4086175 EC50 14.0 nM
CC(C)(C)OC(=O)N1CCC(CCCCCOc2ccc(S(C)(=O)=O)cc2)CC1 CHEMBL4217229 EC50 14.0 nM
CC(C)(C)OC(=O)N1CCC2(CC1)CC(CCCOc1ccc(S(C)(=O)=O)cc1)C2 CHEMBL4227018 EC50 14.0 nM
CCN(c1cc(N2CCc3cc(S(C)(=O)=O)ccc32)ncn1)C1CCN(C(=O)OC(C)(C)C)CC1 CHEMBL4861760 EC50 14.0 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)OC3(C(F)(F)F)CCC3)CC2)c1F CHEMBL3326670 EC50 14.3 nM
CS(=O)(=O)c1ccc(-n2ncc3c(OC4CCN(C(=O)OC5CCCC5)CC4)ncnc32)cc1 CHEMBL1775174 EC50 14.6 nM
Cc1nn(-c2ccc(S(C)(=O)=O)cc2)c2ncnc(OC3CCN(C(=O)OC(C)(C)C)CC3)c12 CHEMBL1773288 EC50 15.0 nM
Cc1ncccc1Oc1ncnc(O[C@H]2C[C@H]3CC[C@@H](C2)N3S(=O)(=O)CC(C)C)c1C CHEMBL3084377 EC50 15.0 nM
Cc1c(Nc2ccc(C#N)cc2F)ncnc1O[C@H]1C[C@H]2CC[C@@H](C1)N2S(=O)(=O)C1CC1 CHEMBL3084388 EC50 15.0 nM
CC1(OC(=O)N2CCC(n3ncc(COc4ccc(-n5cnnn5)cc4)c3C#N)CC2)CC1 CHEMBL2204983 EC50 15.0 nM
Cc1c(Oc2ccc(-n3cnnn3)cc2F)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC1(C)CC1 CHEMBL2312158 Ki 15.0 nM
CC(C)(F)c1noc(N2CCC(COC3CC=C(c4ccc(S(C)(=O)=O)cc4)CC3)CC2)n1 CHEMBL2323595 EC50 15.0 nM
Cc1cc2c(c(Oc3cccc(NS(=O)(=O)c4ccc(Cl)cc4)c3)n1)C(=O)N(C1CC1)C2=O CHEMBL3104889 EC50 15.0 nM
COC(=O)[C@@]1(Cc2cccc(F)c2)NCc2cnc3c(-c4ccc(C(F)(F)F)nc4)c(CO)nn3c21 CHEMBL3354799 EC50 15.0 nM
C[C@@H]1CN(c2nnc(C(F)(F)F)o2)CCN1c1ncc(OCc2ccc(C#N)cc2F)cn1 CHEMBL3357999 EC50 15.0 nM
CCc1cnc(N2CCC(n3ncc4cc(-c5cc(F)c(C(=O)NCCO)cc5F)ncc43)CC2)nc1 CHEMBL3823329 EC50 15.0 nM
COC1CN(C(=O)OC(C)(C)C)CCC1N(C(=O)c1ccc(-c2cnco2)cc1)C1CC1 CHEMBL3909522 EC50 15.0 nM
CC1CN(C(=O)OC(C)(C)C)CCC1N(C(=O)c1ccc(-c2cnco2)cc1)C1CC1 CHEMBL3950359 EC50 15.0 nM
CCNC(=O)c1ccc(-c2cc3nnn(C4CCN(c5ncc(CC)cn5)CC4)c3cn2)c(F)c1 CHEMBL4103709 EC50 15.0 nM
CC1(OC(=O)N2CC3COCC(C2)C3Oc2ncnc(Nc3ccc(F)cc3F)c2F)CC1 CHEMBL4176348 EC50 15.0 nM
CC1(C)C[C@]2(CC[C@H](Oc3cc(N4CCc5cc(S(C)(=O)=O)ccc54)ncn3)CC2)CO1 CHEMBL4460354 EC50 15.0 nM
CC(C)c1noc(N2CCC(Oc3cc(N4CCc5cc(N6CCOCC6=O)ccc54)ncn3)CC2)n1 CHEMBL4798241 EC50 15.0 nM
CO[C@@H](C)c1nc(N2CCN(c3ncc(OCc4ccncc4C#N)cn3)[C@H](C)C2)no1 CHEMBL3220034 pEC50 15.85 nM
CO[C@H](C)c1nc(N2CCN(c3ncc(OCc4ccncc4C#N)cn3)[C@H](C)C2)no1 CHEMBL3220033 pEC50 15.85 nM
C[C@@H]1CN(C(=O)OC2(C(F)(F)F)CCOC2)CCN1c1ncc(OCc2ccncc2C#N)cn1 CHEMBL3220236 pEC50 15.85 nM
C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1c1ncc(OCc2ccc(S(C)(=O)=O)cc2C#N)cn1 CHEMBL2086673 EC50 16.0 nM
CCc1c(Oc2cccnc2C)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C CHEMBL2312506 EC50 16.0 nM
CC(C)(C)OC(=O)N1CCC(CO[C@H]2CC[C@H](c3ccc(S(C)(=O)=O)cc3)CC2)CC1 CHEMBL2323590 EC50 16.0 nM
CCOC(=O)c1cc(Cl)nc(Oc2cccc(NS(=O)(=O)c3ccc(Cl)cc3)c2)c1 CHEMBL2391593 EC50 16.0 nM
Cc1cc2c(c(Oc3cc(NS(=O)(=O)c4ccc(Cl)cc4)ccc3F)n1)C(=O)N(C(C)C)C2=O CHEMBL3104879 EC50 16.0 nM
CC(C)(C)OC(=O)N1CCC(n2ccc3c(N4CCc5cc(S(C)(=O)=O)ccc54)ncnc32)CC1 CHEMBL3113843 EC50 16.0 nM
CCOC(=O)C(Cc1ccccc1)c1ccnc2c(-c3ccc(Cl)cc3)cnn12 CHEMBL3260512 EC50 16.0 nM
CCCc1cnc(N2CCC(C3Cc4c(F)c(C5=CCN(S(=O)(=O)CCCO)CC5)cc(F)c4O3)CC2)nc1 CHEMBL3261140 EC50 16.0 nM
CCCc1cnc(N2CCC(Oc3ccn(-c4ccc(S(C)(=O)=O)cc4)c(=O)c3)CC2)nc1 CHEMBL3338174 EC50 16.0 nM
CS(=O)(=O)c1ccc(-n2cc(Cl)c(OC3CCN(c4ncc(C(F)(F)F)cn4)CC3)cc2=O)cc1F CHEMBL3338191 EC50 16.0 nM
Cc1c(Oc2ccc(C#N)cc2Cl)ncnc1OC1C2COCC1CN(C(=O)OC1(C)CC1)C2 CHEMBL3629477 EC50 16.0 nM
CN(c1cc(N2CCc3cc(S(C)(=O)=O)ccc32)ncn1)[C@H]1CC[C@]2(CC1)COC(C)(C)C2 CHEMBL4545952 EC50 16.0 nM
CC(C)c1noc(N2CCC(Oc3cc(N4CCc5cc(N6CCC[C@H](O)C6=O)ccc54)ncn3)CC2)n1 CHEMBL4779950 EC50 16.0 nM
CC(C)(C)OC(=O)N1CCC(O[C@H]2CC[C@H](Oc3ccc(S(C)(=O)=O)cc3)CC2)CC1 CHEMBL3598081 EC50 16.1 nM
CCS(=O)(=O)c1ccc(Nc2ncnc(N3CCC(c4nc(C(C)C)no4)CC3)c2[N+](=O)[O-])cc1 CHEMBL459873 EC50 17.0 nM
Cc1c(Oc2ccc(-n3cnnn3)cc2)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C CHEMBL2312156 EC50 17.0 nM
C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1c1ncc(OCc2ccc(S(C)(=O)=O)cc2)cn1 CHEMBL2086660 IC50 17.0 nM
CC(C)OC(=O)N1CCC(Oc2cc(N3CCc4cc(S(C)(=O)=O)ccc43)ncn2)CC1 CHEMBL3113840 EC50 17.0 nM
CCOC(=O)[C@](C)(Cc1ccccc1)c1ccnc2c(-c3ccc(Cl)cc3)cnn12 CHEMBL3260518 EC50 17.0 nM
Cc1c(Nc2ccc(C#N)cc2Cl)ncnc1OC1CC2COCC(C1)N2C(=O)OC(C)(C)C CHEMBL3629478 EC50 17.0 nM
CC1(OC(=O)N2CC3COCC(C2)C3Oc2ncnc(Nc3cccnc3Cl)c2F)CC1 CHEMBL4165734 EC50 17.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCC2(CCc3cc(-c4ccc(CS(=O)(=O)Cc5ccccn5)cc4)ccc3O2)CC1 CHEMBL4284899 EC50 17.0 nM
CC(C)c1noc(N2CCC(Oc3cc(N4CCc5cc(N6CCCC(O)C6=O)ccc54)ncn3)CC2)n1 CHEMBL4759952 EC50 17.0 nM
CC(C)c1noc(N2CCC(Oc3cc(N4CCc5cc(N6CCCCC6=O)ccc54)ncn3)CC2)n1 CHEMBL4796498 EC50 17.0 nM
CC[S+]([O-])c1ccc(Nc2ncnc(N3CCC(c4nc(C(C)C)no4)CC3)c2[N+](=O)[O-])cc1 CHEMBL461933 EC50 17.1 nM
CCC(F)(F)C(=O)N1CCC(Oc2ncnc(Oc3ccc(S(C)(=O)=O)nc3C)c2F)CC1 CHEMBL3326681 EC50 17.4 nM
Cc1ccc(N2CCC(C3CCN(c4ccc(S(C)(=O)=O)cc4)CC3)CC2)nc1 CHEMBL1771090 EC50 18.0 nM
Cc1ncccc1Oc1ncnc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3C(=O)OC(C)(C)C)c1C CHEMBL3084363 EC50 18.0 nM
Cc1ncccc1Oc1ncnc(O[C@H]2C[C@H]3CC[C@@H](C2)N3C(=O)OC2(C)CC2)c1C CHEMBL3084365 EC50 18.0 nM
Cc1ncccc1Oc1ncnc(O[C@H]2C[C@H]3C=C[C@@H](C2)N3C(=O)OC(C)C)c1C CHEMBL3084390 EC50 18.0 nM
CN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)[C@@H]1CCN(Cc2nc3cc(F)ccc3s2)C[C@@H]1F CHEMBL2010853 EC50 18.0 nM
NC(=O)CCC1CCN(c2nc(-c3cc(F)c(Cl)cc3F)nc3c2CS(=O)(=O)C3)CC1 CHEMBL2158455 EC 18.0 nM
Cc1c(Oc2ccc(-n3cnnn3)cc2F)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)C CHEMBL2312157 Ki 18.0 nM
N#Cc1cnccc1COc1cnc(N2CCN(C(=O)OCC(F)(F)F)CC2)nc1 CHEMBL2382414 IC50 18.0 nM
CC(C)c1noc(N2CCN(c3ncc(OCc4ccc(CS(C)(=O)=O)cc4F)cn3)[C@H](C)C2)n1 CHEMBL3358013 EC50 18.0 nM
CCCc1cnc(N2CCC(Oc3ccn(-c4ccc(S(C)(=O)=O)cc4F)c(=O)c3)CC2)nc1 CHEMBL3338181 EC50 18.0 nM
CS(=O)(=O)c1ccc(-n2cc(Cl)c(OC3CCN(c4ncc(Cl)cn4)CC3)cc2=O)cc1 CHEMBL3338192 EC50 18.0 nM
CS(=O)(=O)N1CC=C(c2cc3cc(C4CCN(c5nnc(C(F)(F)F)s5)CC4)oc3cn2)CC1 CHEMBL3716724 EC50 18.0 nM
CCNC(=O)c1ccc(-c2cc3nnn(C4CCN(c5ncc(CC)cn5)CC4)c3cn2)cc1C CHEMBL4099540 EC50 18.0 nM
CCNC(=O)c1ccc(-c2cc3nnn(C4CCN(c5ncc(CC)cn5)CC4)c3cn2)cc1Cl CHEMBL4065009 EC50 18.0 nM
CCc1cnc(N2CCC(c3nc(COc4ccc(/C=C5\CC(=O)NC5=O)cc4C)cs3)CC2)nc1 CHEMBL4210640 EC50 18.0 nM
CC(C)OC(=O)N1CCC2(CC1)CC(CCCOc1ccc(S(C)(=O)=O)c(F)c1)C2 CHEMBL4224814 EC50 18.0 nM
CCCN(c1cc(N2CCc3cc(S(C)(=O)=O)ccc32)ncn1)C1CCN(C(=O)OC(C)(C)C)CC1 CHEMBL4877468 EC50 18.0 nM
CC(C)S(=O)(=O)c1cnc(O[C@H]2CC[C@H](OC3CCN(C(=O)OC(C)(C)C)CC3)CC2)cn1 CHEMBL3598091 EC50 18.5 nM
CS(=O)(=O)c1ccc(N2CCC(C3CCN(c4ccc(F)cn4)CC3)CC2)cc1 CHEMBL1771089 EC50 19.0 nM
Cc1cnc(N2CCC(C3CCN(c4cc(C)nc(C#N)n4)CC3)CC2)cn1 CHEMBL1771096 EC50 19.0 nM
Cc1cc2c(c(Sc3cccc(NS(=O)(=O)c4ccc(Cl)cc4)c3)n1)C(=O)N(C(C)C)C2=O CHEMBL3104896 EC50 19.0 nM
COc1cc2c(c(Oc3cccc(NS(=O)(=O)c4ccc(Cl)cc4)c3)n1)C(=O)N(C1CC1)C2=O CHEMBL3104888 EC50 19.0 nM
CC(C)OC(=O)N1CCC(c2cc3cc(C4=CCN(S(C)(=O)=O)CC4)ncc3o2)CC1 CHEMBL3718464 EC50 19.0 nM
CC1(OC(=O)N2CCC(N(C(=O)c3ccc(-c4ccncc4C#N)cc3)C3CC3)CC2)CC1 CHEMBL3946672 EC50 19.0 nM
CC(C)(C)OC(=O)N1CCC(n2nnc3c(Nc4ccc(S(C)(=O)=O)cc4F)ncnc32)CC1 CHEMBL4099566 EC50 19.0 nM
CCNC(=O)c1ccc(-c2cc3nnn(C4CCN(c5ncc(CC)cn5)CC4)c3cn2)c(C)c1 CHEMBL4087339 EC50 19.0 nM
CC1(OC(=O)N2CC3COCC(C2)C3Oc2ncnc(Nc3ccc(-n4cncn4)cc3F)c2F)CC1 CHEMBL4172962 EC50 19.0 nM
Cc1cc(/C=C2\CC(=O)NC2=O)ccc1OCc1csc(C2CCN(C(=O)OC(C)(C)C)CC2)n1 CHEMBL4206682 EC50 19.0 nM
CC1(C)C[C@]2(CC[C@H](Nc3cc(Nc4ccc(S(C)(=O)=O)cc4F)ncn3)CC2)CO1 CHEMBL4591100 EC50 19.0 nM
CC1(OC(=O)N2CCC(n3ncc(COc4ccc(C#N)cc4F)c3C#N)CC2)CC1 CHEMBL2204986 EC50 19.3 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)OC(C)(C)CF)CC2)c1F CHEMBL3325848 EC50 19.9 nM
CC(C)(C)OC(=O)N1CCC(Oc2ncnc3c2CCN3c2ccc(S(C)(=O)=O)cc2F)CC1 CHEMBL2177785 pEC50 19.95 nM
C[C@@H]1CN(C(=O)OC2(C(F)(F)F)COC2)CCN1c1ncc(OCc2ccncc2C#N)cn1 CHEMBL3220237 pEC50 19.95 nM
Cc1ncccc1Oc1ncnc(OC2C3COCC2CN(C(=O)OC(C)C)C3)c1C CHEMBL1766082 Ki 20.0 nM
O=C(NC1CC1)c1ccc(OCC2CC2C2CCN(c3ncc(Cl)cn3)CC2)cc1F CHEMBL1771097 EC50 20.0 nM
C[C@@H]1CN(C(=O)OCC(F)(F)F)CCN1c1ncc(OCc2ccncc2C#N)cn1 CHEMBL2086687 EC50 20.0 nM
Cc1ncccc1Oc1ncnc(O[C@H]2[C@@H]3COC[C@H]2CN(C(=O)OC(C)C)C3)c1C CHEMBL2171708 Ki 20.0 nM
N#Cc1cnccc1COc1cnc(N2CCN(C(=O)OC3CC(F)(F)C3(F)F)CC2)nc1 CHEMBL2382411 EC50 20.0 nM
CC(C)c1noc(-c2cc(Cl)nc(Oc3cccc(NS(=O)(=O)c4ccc(Cl)cc4)c3)c2)n1 CHEMBL2391601 EC50 20.0 nM
CCOC(=O)C(C)(Cc1ccccc1)c1ccnc2c(-c3ccc(Cl)cc3)cnn12 CHEMBL3260517 EC50 20.0 nM
CCOC(=O)[C@](C)(Cc1ccccc1)c1cnnc2c(-c3ccc(C(F)(F)F)cc3)cnn12 CHEMBL3260540 EC50 20.0 nM
CCOC(=O)C1(Cc2ccccc2)CCc2cnc3c(-c4ccc(Oc5ccccc5)cc4)cnn3c21 CHEMBL3354787 EC50 20.0 nM
COC(=O)[C@@]1(Cc2cccc(F)c2)NCc2cnc3c(-c4ccc(C(F)(F)F)cc4)c(C(N)=O)nn3c21 CHEMBL3354803 EC50 20.0 nM
C[C@@H]1CN(C(=O)OC2(C(F)(F)F)COC2)CCN1c1ncc(OCc2ccc(CS(C)(=O)=O)cc2F)cn1 CHEMBL3358010 EC50 20.0 nM
CC(C)(C)OC(=O)N1CCC(n2ncc3cc(-c4ccc(S(C)(=O)=O)cc4)ncc32)CC1 CHEMBL3822759 EC50 20.0 nM
C[C@@H]1CN(c2noc(C(F)F)n2)CCN1c1ncc(OCc2ccncc2C#N)cn1 CHEMBL2086694 EC50 21.0 nM
NC(=O)C1CCN(c2nc(-c3cc(F)c(Cl)cc3F)nc3c2CS(=O)(=O)C3)CC1 CHEMBL2158449 EC 21.0 nM
C[S+]([O-])c1cc(F)c(NC(=O)C2=NOC3(CCN(c4nc(-c5ccccc5)no4)CC3)C2)cc1F CHEMBL2181671 EC50 21.0 nM
CC(C)OC(=O)N1CCC(CO[C@H]2CC[C@H](c3ccc(S(C)(=O)=O)cc3F)CC2)CC1 CHEMBL2323591 EC50 21.0 nM
CC(C)(C)OC(=O)N1CCC(CCOC(=O)N2CCc3cc(S(C)(=O)=O)cc(Cl)c32)CC1 CHEMBL3113637 EC50 21.0 nM
Fc1cccc(CC2(C3CC3)NCc3cnc4c(-c5ccc(C(F)(F)F)cc5)cnn4c32)c1 CHEMBL3354797 EC50 21.0 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)OC(C)C)CC2)c1F CHEMBL3325843 EC50 21.0 nM
C[C@@H]1CN(c2nnc(C(F)(F)F)o2)CCN1c1ncc(OCc2ccc(S(C)(=O)=O)cc2F)cn1 CHEMBL3357994 EC50 21.0 nM
CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3ccncc3C#N)c(F)c2)C2CC2)CC1 CHEMBL3941335 EC50 21.0 nM
CCc1cnc(N2CCC(n3nnc4cc(-c5ccc(S(C)(=O)=O)cc5)ncc43)CC2)nc1 CHEMBL4059986 EC50 21.0 nM
CN(C)C(=O)c1ccc(OCCCCC[C@H]2CC[C@@]3(CCCCO3)CC2)cc1 CHEMBL4207878 EC50 21.0 nM
CN(c1cc(N2CCc3cc(S(C)(=O)=O)ccc32)ncn1)C1CCN(C(=O)OC(C)(C)C)CC1 CHEMBL4871114 EC50 21.0 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)c3noc(C(C)C)n3)CC2)c1F CHEMBL3326685 EC50 21.2 nM
CC(C)(C)OC(=O)N1CCC(C2CCN(c3ccc(S(C)(=O)=O)cc3)CC2)CC1 CHEMBL1771068 EC50 22.0 nM
CCC1(OC(=O)N2CCC(Oc3ncnc(Oc4ccc(S(C)(=O)=O)nc4C)c3F)CC2)CC1 CHEMBL3326668 EC50 22.0 nM
CC[C@@H]1CC(=O)NN=C1c1ccc2nc(-c3ccc(OCCN(C(C)C)C(C)C)cc3)oc2c1 CHEMBL4113048 EC50 22.0 nM
Cc1cc2c(c(Oc3cccc(NS(=O)(=O)c4ccc(Cl)cc4)c3)n1)C(=O)N(C)C2=O CHEMBL3104891 EC50 23.0 nM
CCOC(=O)[C@](C)(Cc1ccccc1)c1ccnc2c(-c3ccc(C(F)(F)F)cc3)c(C)nn12 CHEMBL3354776 EC50 23.0 nM
CS(=O)(=O)c1ccc(-n2ccc(OC3CCN(c4ncc(C5CC5)cn4)CC3)cc2=O)cc1 CHEMBL3338173 EC50 23.0 nM
CC(C)(OC(=O)N1CCC(n2ncc3cc(-c4ccc(S(C)(=O)=O)cc4)ncc32)CC1)C(F)F CHEMBL3822488 EC50 23.0 nM
CS(=O)(=O)c1ccc(OCCCC2CC3(CCN(C(=O)OC4CCCC4)CC3)C2)cc1F CHEMBL4229160 EC50 23.0 nM
CN(C)C(=O)c1ccc(Nc2ncnc(N3CCC(c4nc(C(C)(C)F)no4)CC3)c2F)c(F)c1 CHEMBL2204980 EC50 23.4 nM
CS(=O)(=O)c1ccc(Nc2ncnc(N3CCC(c4nc(-c5cccc(C(F)(F)F)c5)no4)CC3)c2[N+](=O)[O-])cc1 CHEMBL500750 EC50 24.0 nM
Cc1ncccc1Oc1ncnc(O[C@H]2C[C@H]3CC[C@@H](C2)N3C(=O)OC(C)C)c1C CHEMBL3084364 EC50 24.0 nM
Cc1ncccc1Oc1ncnc(O[C@H]2C[C@H]3CC[C@@H](C2)N3S(=O)(=O)C2CC2)c1C CHEMBL3084374 EC50 24.0 nM
CN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)[C@@H]1CCN(Cc2nc3ccccc3s2)C[C@@H]1F CHEMBL2010852 EC50 24.0 nM
CCC[C@H]1C(=O)NN=C(c2ccc3nc(-c4ccc(OC(C)C)cc4)oc3c2)[C@@H]1C CHEMBL4112510 EC50 24.0 nM
CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3ccc(C#N)s3)cc2)C2CC2)CC1 CHEMBL3892438 EC50 24.0 nM
CC(C)c1noc(N2CCC(Oc3cc(N4CCc5cc(N6CCCNS6(=O)=O)ccc54)ncn3)CC2)n1 CHEMBL4763323 EC50 24.0 nM
CSc1ccc(COc2ccc(-c3ncc(C)c(N4CCN(c5ncc(OCC=C(C)C)cn5)CC4)n3)cc2)cc1 CHEMBL5275303 EC50 24.0 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)C3(F)CCC3)CC2)c1F CHEMBL3326682 EC50 24.7 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)SC3CC3)CC2)c1F CHEMBL3326674 EC50 24.9 nM
CS(=O)(=O)c1ccc(Nc2ncnc(N3CCC(c4nc(C5CC5)no4)CC3)c2[N+](=O)[O-])cc1 CHEMBL451798 EC50 25.0 nM
CC(=O)c1ccc(N2CCC(C3CCN(C(=O)OC(C)(C)C)CC3)CC2)cc1 CHEMBL1771071 EC50 25.0 nM
Cc1ncccc1Oc1ncnc(O[C@H]2C[C@H]3CC[C@@H](C2)N3S(=O)(=O)c2ccc(Cl)s2)c1C CHEMBL3084378 EC50 25.0 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)OC(C)C)CC2)c1C CHEMBL1951021 EC50 25.0 nM
C[C@@H]1CN(c2nc(C3CC3)no2)CCN1c1ncc(OCc2ccncc2C#N)cn1 CHEMBL2087085 EC50 25.0 nM
CC(C)(C)OC(=O)N1CCC(CCOC(=O)N2CCc3cc(S(C)(=O)=O)cc(F)c32)CC1 CHEMBL3113636 EC50 25.0 nM
CC(C)(C)OC(=O)N1CCC(CCOC(=O)N2CCc3c2ccc(S(C)(=O)=O)c3F)CC1 CHEMBL3113631 EC50 25.0 nM
CCOC(=O)[C@@]1(Cc2ccccc2)CNc2cnc3c(-c4ccc(C(F)(F)F)cc4)cnn3c21 CHEMBL3354789 EC50 25.0 nM
CC1(OC(=O)N2CC3COCC(C2)C3Oc2cc(Nc3ccc(C#N)cc3Cl)ncn2)CC1 CHEMBL3629596 EC50 25.0 nM
CC(C)(C)OC(=O)N1CCC2(CC1)CC(CCCOc1ccc(S(C)(=O)=O)cc1F)C2 CHEMBL4226193 EC50 25.0 nM
CC(O[C@H]1CC[C@]2(CCC(C)(C)CO2)CC1)c1nc(-c2ccc(CS(C)(=O)=O)c(F)c2)no1 CHEMBL4458134 EC50 25.0 nM
CC(C)c1noc(N2CCC(Oc3cc(N4CCc5cc(N6CCC[C@@H](O)C6=O)ccc54)ncn3)CC2)n1 CHEMBL4739871 EC50 25.0 nM
CC(C)COC(=O)N1CCC(Oc2ncnc3c2CCN3c2ccc(S(C)(=O)=O)cc2F)CC1 CHEMBL2181694 pEC50 25.12 nM
C[C@@H]1CN(c2nnc(C(F)(F)F)o2)CCN1c1ncc(OCc2ccncc2C#N)cn1 CHEMBL3218816 pEC50 25.12 nM
N#Cc1cnccc1COc1cnc(N2CCN(c3nnc(C(F)(F)F)o3)CC2)nc1 CHEMBL4229220 pEC50 25.12 nM
CC1(OC(=O)N2CCC(O[C@H]3CC[C@H](Oc4cnc(S(C)(=O)=O)cn4)CC3)CC2)CC1 CHEMBL3598095 EC50 25.9 nM
CN(c1ncnc2c(-c3ccc(S(C)(=O)=O)cc3F)csc12)C1CCN(C(=O)OC2(C)CC2)CC1 CHEMBL3321837 EC50 26.0 nM
CC1(OC(=O)N2CC3COCC(C2)C3Oc2ncnc(Oc3ccccc3F)c2F)CC1 CHEMBL4162299 EC50 26.0 nM
CNC(=O)c1ccc(Nc2ncnc(N3CCC(c4nc(C(C)(C)F)no4)CC3)c2F)c(F)c1 CHEMBL2203304 EC50 27.0 nM
C[C@@H]1CN(c2nnc(C(F)(F)F)o2)CCN1c1ncc(OCc2ccc(CS(C)(=O)=O)cc2F)cn1 CHEMBL3358001 EC50 27.0 nM
CC(C)OC(=O)N1CCC(n2ncc3cc(-c4ccc(S(C)(=O)=O)cc4F)ncc32)CC1 CHEMBL3823669 EC50 27.0 nM
CC[C@H]1OC(=O)NN=C1N1CCc2nc(-c3ccccc3)oc2C1 CHEMBL4115113 EC50 27.0 nM
CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3ccncc3C#N)cc2)C2CC2)CC1 CHEMBL3984023 EC50 27.0 nM
CCNC(=O)c1c(C)cc(-c2cc3nnn(C4CCN(c5ncc(CC)cn5)CC4)c3cn2)cc1C CHEMBL4064583 EC50 27.0 nM
CN(C)C(=O)c1ccc(OCCCCCC2CCC3(CCCCC3)CC2)cc1 CHEMBL4205711 EC50 27.0 nM
C[C@@H](O[C@H]1CC[C@@]2(CC1)CC(F)(F)CCO2)c1nc(-c2cc(F)c(CS(C)(=O)=O)c(F)c2)no1 CHEMBL4525262 EC50 27.0 nM
C[C@@H](O[C@H]1CC[C@]2(CC1)COC(C)(C)C2)c1nc(-c2ccc(CS(C)(=O)=O)c(F)c2)no1 CHEMBL4515029 EC50 27.0 nM
O=S1(=O)Cc2nc(-c3cc(F)c(Cl)cc3F)nc(N3CCOCC3)c2C1 CHEMBL2158462 EC 28.0 nM
CCCc1cnc(N2CCC(C3(C)Cc4cc(C5=CCN(S(=O)(=O)CCCCO)CC5)ccc4O3)CC2)nc1 CHEMBL3261143 EC50 28.0 nM
CS(=O)(=O)N1CC=C(c2cc3cc(C4CCN(CC5(C(F)(F)F)CC5)CC4)oc3cn2)CC1 CHEMBL3715997 EC50 28.0 nM
CC(C)(F)c1noc(C2CCN(c3ncnc(Nc4ccc(C(N)=O)cc4F)c3F)CC2)n1 CHEMBL2204981 EC50 28.2 nM
CO[C@@H]1CN(Cc2ccc(C(F)(F)F)cc2)CC[C@@H]1N(C)C(=O)Cc1ccc(-n2cnnn2)cc1 CHEMBL2010846 EC50 29.0 nM
CN(C(=O)Cc1ccc(-n2cnnn2)cc1)[C@H]1CCN(Cc2ccc(C(F)(F)F)cc2)C[C@H]1F CHEMBL2010844 EC50 29.0 nM
C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1c1ncc(OCC2CCN(S(C)(=O)=O)CC2)cn1 CHEMBL2086668 EC50 29.0 nM
CN(C)C(=O)c1ccc(OCCCCCC2CCC3(CC2)OCCCO3)cc1 CHEMBL4203517 EC50 29.0 nM
CC(C)OC(=O)N1CCC2(CC1)CC(CCCOc1ccc(C(=O)N3CCCC3)c(F)c1)C2 CHEMBL4227731 EC50 29.0 nM
CC(O[C@H]1CC[C@@]2(CC1)CC(C)(C)CCO2)c1nc(-c2ccc(CS(C)(=O)=O)c(F)c2)no1 CHEMBL4441437 EC50 29.0 nM
COCCN(c1cc(N2CCc3cc(S(C)(=O)=O)ccc32)ncn1)C1CCN(C(=O)OC(C)(C)C)CC1 CHEMBL4873459 EC50 29.0 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)OC3(C(F)(F)F)COC3)CC2)c1F CHEMBL3326671 EC50 29.3 nM
Cc1cnc(N2CCC(C3CCN(c4cc(C#N)nc(C)n4)CC3)CC2)cn1 CHEMBL1771095 EC50 30.0 nM
Cc1ncccc1Oc1ncnc(O[C@H]2C[C@H]3CC[C@@H](C2)N3C(=O)OC2CCC2)c1C CHEMBL3084370 EC50 30.0 nM
CCCCS(=O)(=O)N1[C@@H]2CC[C@H]1C[C@@H](Oc1ncnc(Oc3cccnc3C)c1C)C2 CHEMBL3084362 EC50 30.0 nM
N#Cc1cc(F)c(NC(=O)C2=NOC3(CCN(c4nc(-c5ccccc5)no4)CC3)C2)cc1F CHEMBL2181672 EC50 30.0 nM
N#Cc1ccc(S(=O)(=O)N2CCCc3ccc(Oc4cc(-c5nc(C6CC6)no5)cc(Cl)n4)cc32)cc1 CHEMBL3113011 EC50 30.0 nM
COC(=O)c1cc(Cl)nc(Oc2ccc3c(c2)N(S(=O)(=O)c2ccc(Cl)cc2)CC3)c1 CHEMBL3112997 EC50 30.0 nM
Cc1ccc(N2CCC(n3ncc4cc(-c5ccc(S(C)(=O)=O)cc5)ncc43)CC2)nc1 CHEMBL3822863 EC50 30.0 nM
CC[C@@H]1CC(=O)NN=C1c1ccc2nc(-c3ccc(OC(C)C)cc3)oc2c1 CHEMBL4114940 EC50 30.0 nM
CC(C)(C)OC(=O)N1CC[C@@H](N(C(=O)c2ccc(-c3cnco3)cc2)C2CC2)[C@@H](F)C1 CHEMBL3894640 EC50 30.0 nM
CC(F)Cc1nc(CN2CCC(O[C@H]3CC[C@H](Oc4cnc(S(C)(=O)=O)cn4)CC3)CC2)no1 CHEMBL3598115 EC50 30.3 nM
CC(C)OC(=O)N1CCC(Oc2cc(Nc3ccc(S(C)(=O)=O)cc3F)ncn2)CC1 CHEMBL1951118 EC50 31.0 nM
N#Cc1c(C(=O)NC2CC2)cc(C2CC2)nc1Oc1cccc(NS(=O)(=O)c2ccc(Cl)cc2)c1 CHEMBL2391433 EC50 31.0 nM
CCCc1cnc(N2CCC(Oc3cc(=O)n(-c4ccc(S(C)(=O)=O)cc4)cc3C)CC2)nc1 CHEMBL3338185 EC50 31.0 nM
CC(C)(C)OC(=O)N1CCC(n2ncc3cc(-c4ccc(S(C)(=O)=O)cc4)ccc32)CC1 CHEMBL3823843 EC50 31.0 nM
CC1OC(=O)NN=C1c1ccc2nc(-c3ccccc3)oc2c1 CHEMBL3947320 EC50 31.0 nM
CCc1cnc(N2CCC(n3nnc4cc(-c5ccc(S(C)(=O)=O)cc5)ccc43)CC2)nc1 CHEMBL4088233 EC50 31.0 nM
CC(C)(C)COC(=O)N1CCC2(CC1)CC(CCCOc1ccc(S(C)(=O)=O)c(F)c1)C2 CHEMBL4225414 EC50 31.0 nM
CCc1cnc(N2CCC3(CC2)CC(CCCOc2ccc(S(C)(=O)=O)cc2)C3)nc1 CHEMBL4228905 EC50 31.0 nM
CC(O[C@H]1CC[C@@]2(CC1)CC(C)(C)CO2)c1nc(-c2ccc(CS(C)(=O)=O)c(F)c2)no1 CHEMBL4456673 EC50 31.0 nM
C[C@@H](CF)OC(=O)N1CCC(O[C@H]2CC[C@H](Oc3cnc(S(C)(=O)=O)cn3)CC2)CC1 CHEMBL3598097 EC50 31.1 nM
CCSC(=O)N1CCC(Oc2ncnc3c2CCN3c2ccc(S(C)(=O)=O)cc2F)CC1 CHEMBL2177761 pEC50 31.62 nM
CC(C)OC(=O)N1CCC(C(C)CNC(=O)Cc2c(F)ccc(F)c2F)CC1 CHEMBL1684037 EC50 32.0 nM
CCCS(=O)(=O)N1[C@@H]2CC[C@H]1C[C@@H](Oc1ncnc(Oc3cccnc3C)c1C)C2 CHEMBL3084375 EC50 32.0 nM
CCCc1cnc(N2CCC(Oc3ccn(-c4ccc(N5CCCC5=O)cc4)c(=O)c3)CC2)nc1 CHEMBL3338178 EC50 32.0 nM
CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3cncs3)cc2)C2CC2)CC1 CHEMBL3889992 EC50 32.0 nM
Cc1c(Oc2ccc(-n3cncn3)cc2F)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C CHEMBL2312161 Ki 33.0 nM
Cc1cc2c(c(Oc3cc(NS(=O)(=O)c4ccc(Cl)cc4)ccc3Cl)n1)C(=O)N(C(C)C)C2=O CHEMBL3104880 EC50 33.0 nM
CC(C)c1noc(N2CCC(CC(F)CNc3ccc4c(c3)C(=O)CC4)CC2)n1 CHEMBL3809973 EC50 33.0 nM
CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3cnco3)cc2)C2CC2)CC1 CHEMBL3928358 EC50 33.0 nM
CC(C)NC(=O)c1cc(F)c(-c2cc3nnn(C4CCN(C(=O)OC(C)C)CC4)c3cn2)cc1F CHEMBL4097347 EC50 33.0 nM
Cc1c(Nc2ccc(C(=O)N(C)C)cc2F)ncnc1O[C@H]1CC[C@]2(CC1)COC(C)(C)C2 CHEMBL4569726 EC50 33.0 nM
CC(C)c1noc(N2CCC(Oc3cc(N4CCc5cc(N6CCCC6=O)ccc54)ncn3)CC2)n1 CHEMBL4788517 EC50 33.0 nM
CC(C)(C)OC(=O)N1CCC(Oc2ncnc3c2ncn3-c2ccc(S(C)(=O)=O)cc2)CC1 CHEMBL1773290 EC50 33.4 nM
Cc1c(Nc2ccc(F)cc2C#N)ncnc1O[C@H]1C[C@H]2CC[C@@H](C1)N2S(=O)(=O)C1CC1 CHEMBL3084387 EC50 34.0 nM
Cc1c(Nc2ccc(S(C)(=O)=O)cc2F)ncnc1OC1CCN(C(=O)OC(C)C)CC1 CHEMBL1951012 EC50 34.0 nM
CCCS(=O)(=O)N1CC=C(c2ccc3c(c2)CC(C2CCN(c4ccc(C(F)(F)F)cn4)CC2)O3)CC1 CHEMBL3261129 EC50 34.0 nM
COC(=O)C1(Cc2ccccc2)OCc2cnc3c(-c4ccc(C(F)(F)F)cc4)cnn3c21 CHEMBL3354790 EC50 34.0 nM
CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3ccc(C#N)nc3)cc2)C2CC2)CC1 CHEMBL3915303 EC50 34.0 nM
O=C(OC1CCCC1)N1CCC(N(C(=O)c2ccc(-c3cnco3)cc2)C2CC2)CC1 CHEMBL3928136 EC50 34.0 nM
CC(C)OC(=O)N1CCC2(CC1)CC(CCCOc1ccc(C(=O)N3CCC3)c(F)c1)C2 CHEMBL4226885 EC50 34.0 nM
[2H]C([2H])(O)c1nn2c3c(cnc2c1-c1ccc(C(F)(F)F)nc1)CN[C@]3(Cc1cccc(F)c1)C(=O)OC CHEMBL3354802 EC50 35.0 nM
CC(C)c1noc(N2CCC3(CC2)CC(CCCOc2ccc(S(C)(=O)=O)cc2)C3)n1 CHEMBL4227707 EC50 35.0 nM
CN(C)C(=O)c1ccc(OCCCCC[C@H]2CC[C@]3(CCCCO3)CC2)cc1 CHEMBL4209951 EC50 36.0 nM
CC(C)(C)OC(=O)N1[C@@H]2CC[C@H]1C[C@@H](Oc1ncnc3c(Nc4ccc(C#N)cc4F)ncnc13)C2 CHEMBL4240810 EC50 36.0 nM
CC(C)c1noc(N2CCC(Oc3cc(N4CCc5cc(N6CCNCC6=O)ccc54)ncn3)CC2)n1 CHEMBL4746627 EC50 36.0 nM
C[C@H](CF)OC(=O)N1CCC(O[C@H]2CC[C@H](Oc3cnc(S(C)(=O)=O)cn3)CC2)CC1 CHEMBL3598096 EC50 36.8 nM
Cc1ncccc1Oc1ncnc(O[C@H]2C[C@H]3CC[C@@H](C2)N3C(=O)OCC2CC2)c1C CHEMBL3084368 EC50 37.0 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)C(C)(F)F)CC2)c1F CHEMBL3326680 EC50 37.0 nM
CCCc1cnc(N2CCC(Oc3ccn(-c4ccc(NC(=O)C(C)(C)C)cc4)c(=O)c3)CC2)nc1 CHEMBL3338177 EC50 37.0 nM
CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(OCCN(C(C)C)C(C)C)cc3)oc2c1 CHEMBL3917552 EC50 37.0 nM
CCC[C@@H]1C(=O)NN=C(c2ccc3nc(-c4ccc(OC(C)C)cc4)oc3c2)[C@H]1C CHEMBL3892950 EC50 37.0 nM
CCNC(=O)c1cc(F)c(-c2cc3nnn(C4CCN(C(=O)OC(C)C)CC4)c3cn2)cc1F CHEMBL4079321 EC50 37.0 nM
Cc1ncccc1Oc1ncnc(O[C@H]2C[C@H]3CC[C@@H](C2)N3C(=O)OC(C)C2CC2)c1C CHEMBL3084369 EC50 38.0 nM
Cc1ncccc1Oc1ncnc(O[C@H]2C[C@H]3C=C[C@@H](C2)N3S(=O)(=O)C2CC2)c1C CHEMBL3084392 EC50 38.0 nM
CC(C)(C)OC(=O)N1CCC(COC2CC=C(c3ccncc3C#N)CC2)CC1 CHEMBL2323601 EC50 38.0 nM
CC(C)c1noc(N2CCC(CO[C@H]3CC[C@H](c4ccc(S(C)(=O)=O)cc4F)CC3)CC2)n1 CHEMBL2323593 EC50 38.0 nM
CCOC(=O)[C@]1(Cc2ccccc2)CCc2cnc3c(-c4ccc(C(F)(F)F)cc4)cnn3c21 CHEMBL3352841 EC50 38.0 nM
CS(=O)(=O)c1cnc(O[C@H]2CC[C@H](OC3CCN(C(=O)C4(C(F)(F)F)CCCC4)CC3)CC2)cn1 CHEMBL3598105 EC50 38.4 nM
CS(=O)(=O)c1ccc(N2CCC(C3CCN(c4ccccn4)CC3)CC2)cc1 CHEMBL1771083 EC50 39.0 nM
C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1c1ncc(OCc2ccc(C#N)cc2)cn1 CHEMBL2086670 EC50 39.0 nM
C[C@@H]1CN(c2ncc(OCc3ccc(S(C)(=O)=O)cc3)cn2)[C@@H](C)CN1C(=O)OC(C)(C)C CHEMBL2086665 EC50 39.0 nM
Cc1c(Oc2ccc(-n3cnnn3)cc2)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC1(C)CC1 CHEMBL2312516 EC50 39.0 nM
CN(c1ncnc2c(-c3ccc(S(C)(=O)=O)cc3)csc12)C1CCN(C(=O)OC(C)(C)C)CC1 CHEMBL3321826 EC50 39.0 nM
CCC[C@H]1C(=O)NN=C(c2ccc3nc(-c4ccccc4)oc3c2)[C@@H]1C CHEMBL4107094 EC50 39.0 nM
CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3ccc(C(N)=O)cc3)cc2)C2CC2)CC1 CHEMBL3932795 EC50 39.0 nM
CCNC(=O)c1ccc(-c2cc3nnn(C4CCN(c5ncc(CC)cn5)CC4)c3cn2)cc1C(F)(F)F CHEMBL4073169 EC50 39.0 nM
CN(c1ncnc2c1CCN2c1ccc(S(C)(=O)=O)cc1F)[C@H]1CC[C@]2(CC1)COC(C)(C)C2 CHEMBL4592464 EC50 39.0 nM
CC(C)(C)COC(=O)N1CCC(Oc2ncnc3c2CCN3c2ccc(S(C)(=O)=O)cc2F)CC1 CHEMBL2181695 pEC50 39.81 nM
Cc1c(Oc2ccc(S(C)(=O)=O)cc2F)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C CHEMBL2312517 EC50 40.0 nM
Cc1ncccc1Oc1ncnc(N2C3CC4CC2CC(C3)N4C(=O)OC(C)(C)C)c1C CHEMBL2312524 EC50 40.0 nM
O=S(=O)(c1ccc(Cl)cc1)N1CCCc2cc(F)c(Oc3cc(-c4nc(C5CC5)no4)cc(Cl)n3)cc21 CHEMBL3112990 EC50 40.0 nM
CCOC(=O)C(C)(Cc1cccc(C)c1)c1ccnc2c(-c3ccc(Cl)cc3)cnn12 CHEMBL3260522 EC50 40.0 nM
CCOC(=O)C(C)(Cc1cscn1)c1ccnc2c(-c3ccc(Cl)cc3)cnn12 CHEMBL3260527 EC50 40.0 nM
CC(C)OC(=O)N1CCC2(CC1)CC(CCCOc1ccc(C(=O)N3CC(O)C3)c(F)c1)C2 CHEMBL4226586 EC50 40.0 nM
C[C@H]1CN(C(=O)OC(C)(C)C)CCN1c1ncc(OCc2ccc(S(C)(=O)=O)cc2)cn1 CHEMBL2086659 EC50 41.0 nM
CCCc1cnc(N2CCC(Oc3ccn(-c4ccc([S+](C)[O-])cc4)c(=O)c3)CC2)nc1 CHEMBL3338175 EC50 41.0 nM
CS(=O)(=O)N1CC=C(c2cc3cc(C4CCN(c5ncc(Cl)cn5)CC4)oc3cn2)CC1 CHEMBL3715366 EC50 41.0 nM
CC[C@H]1OC(=O)NN=C1c1ccc2nc(-c3ccccc3)oc2c1 CHEMBL4110815 EC50 41.0 nM
CC[C@@H]1CC(=O)NN=C1c1ccc2nc(-c3ccc(N(C)C)cc3)oc2c1 CHEMBL4112167 EC50 41.0 nM
CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3ccncc3)cc2)C2CC2)CC1 CHEMBL3909108 EC50 41.0 nM
CCc1cnc(N2CCC(c3coc4c(N5CCc6cc(S(C)(=O)=O)ccc65)ncnc34)CC2)nc1 CHEMBL4094202 EC50 41.0 nM
CC(C)c1noc(N2CCC(Oc3cc(N4CCc5cc(S(=O)(=O)CCO)ccc54)ncn3)CC2)n1 CHEMBL4752544 EC50 41.0 nM
CC(C)c1noc(C2CCN(c3ncnc4c3cnn4-c3ccc(S(C)(=O)=O)cc3)CC2)n1 CHEMBL1773295 EC50 42.0 nM
Cc1ncccc1Oc1ncnc(O[C@H]2C[C@H]3CC[C@@H](C2)N3S(=O)(=O)c2ccc(F)cc2)c1C CHEMBL3084379 EC50 42.0 nM
Cc1nc(S(C)(=O)=O)ccc1[C@H]1CC[C@H](OCC2CCN(c3ncc(C(F)(F)F)cn3)CC2)CC1 CHEMBL2323596 EC50 42.0 nM
CC(C)OC(=O)N1CCC(n2ncc3cc(-c4ccc(S(C)(=O)=O)cc4)ncc32)CC1 CHEMBL3822500 EC50 42.0 nM
CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(N(C)C)cc3)oc2c1 CHEMBL3987172 EC50 42.0 nM
CC(C)OC(=O)N1CC[C@H](N(C(=O)c2ccc(-n3cncn3)c(F)c2)C2CC2)[C@H](F)C1 CHEMBL4109770 EC50 42.0 nM
CS(=O)(=O)c1ccc2c(c1)CCN2c1ncnc2c(C3CCN(c4ncc(Cl)cn4)CC3)coc12 CHEMBL4101938 EC50 42.0 nM
CCc1c(Nc2ccc(S(C)(=O)=O)cc2F)ncnc1O[C@H]1CC[C@]2(CC1)COC(C)(C)C2 CHEMBL4467458 EC50 42.0 nM
Cc1c(Oc2cccc(/C=C3\SC(=O)NC3=O)c2)ncnc1OC1CCN(C(=O)OC(C)(C)C)CC1 CHEMBL4784457 EC50 43.0 nM
CC(C)(C)OC(=O)N1CCC(N(c2cc(NC3CCN(S(C)(=O)=O)CC3)ncn2)C(F)(F)F)CC1 CHEMBL4876465 EC50 43.0 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)c3nc(C(C)(C)F)no3)CC2)c1F CHEMBL3326687 EC50 43.4 nM
Cn1nnnc1-c1ccc(OCc2cnn(C3CCN(C(=O)OC4(C)CC4)CC3)c2C#N)c(F)c1 CHEMBL2204982 EC50 43.6 nM
C[C@H](CNC(=O)Cc1c(F)ccc(F)c1F)C1CCN(C(=O)OC2(C)CC2)CC1 CHEMBL2092727 EC50 44.0 nM
Cc1c(Oc2ccccc2Cl)ncnc1O[C@H]1C[C@H]2CC[C@@H](C1)N2S(=O)(=O)C1CC1 CHEMBL3084382 EC50 44.0 nM
CCOc1c(Nc2ccc(S(C)(=O)=O)nc2C)ncnc1OC1CCN(C(=O)OC(C)C)CC1 CHEMBL1951033 EC50 44.0 nM
NC(=O)CN1CCN(c2nc(-c3cc(F)c(Cl)cc3F)nc3c2CS(=O)(=O)C3)CC1 CHEMBL2158446 EC 44.0 nM
Cc1cc(S(C)(=O)=O)cc2c1N(C(=O)OCCC1CCN(C(=O)OC(C)(C)C)CC1)CC2 CHEMBL3113835 EC50 44.0 nM
Cc1c(Nc2ccc(S(C)(=O)=O)cc2Cl)ncnc1OC1CC2COCC(C1)N2C(=O)OC(C)(C)C CHEMBL3629479 EC50 44.0 nM
CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3ccc(S(C)(=O)=O)cc3F)cc2)C2CC2)CC1 CHEMBL3896881 EC50 44.0 nM
CC(C)(C)OC(=O)N1[C@@H]2CC[C@H]1C[C@@H](Nc1ncnc3c(Nc4ccc(S(C)(=O)=O)cc4)ncnc13)C2 CHEMBL4242383 EC50 44.0 nM
CC(O[C@H]1CC[C@]2(CC1)COC(C)(C)C2)c1nc(-c2ccc(CS(C)(=O)=O)c(F)c2)no1 CHEMBL4441091 EC50 44.0 nM
CC(C)(C)OC(=O)N1[C@@H]2CC[C@@H]1CC(Oc1ncnc(Oc3ccccc3Cl)c1[N+](=O)[O-])C2 CHEMBL3894993 EC50 44.2 nM
C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1c1ncc(OCc2ccc(S(C)(=O)=O)cn2)cn1 CHEMBL2086674 EC50 45.0 nM
O=C1c2cc(C3CC3)nc(Oc3cccc(NS(=O)(=O)c4ccc(Cl)cc4)c3)c2C(=O)N1C1CC1 CHEMBL3104887 EC50 45.0 nM
CCNC(=O)c1ccc(-c2cc3cc(C4CCN(C(=O)OC(C)(C)C)CC4)oc3cn2)cc1 CHEMBL3715068 EC50 45.0 nM
CC(C)(C)COC(=O)N1CCC(N(C(=O)c2ccc(-c3cnco3)cc2)C2CC2)CC1 CHEMBL3966876 EC50 45.0 nM
CC(C)COC(=O)N1CCC(N(C(=O)c2ccc(-c3cnco3)cc2)C2CC2)CC1 CHEMBL3950435 EC50 45.0 nM
CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3cnco3)cc2F)C2CC2)CC1 CHEMBL3956393 EC50 45.0 nM
Cc1c(Nc2ccc(S(C)(=O)=O)cc2F)ncnc1N(C)[C@H]1CC[C@]2(CC1)COC(C)(C)C2 CHEMBL4585818 EC50 45.0 nM
COc1c(Nc2ccc(S(C)(=O)=O)nc2C)ncnc1OC1CCN(C(=O)OC(C)C)CC1 CHEMBL1951032 EC50 46.0 nM
CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3c(c2)C(=O)CC3)CC1 CHEMBL2058403 EC50 46.0 nM
CC(C)OC(=O)N1CCC(n2ncc3cc(-c4cc(F)c(C(=O)N(C)C)cc4F)ncc32)CC1 CHEMBL3823379 EC50 46.0 nM
CCC[C@@H]1C(=O)NN=C(c2ccc3nc(-c4ccc(OCCN5C[C@@H](C)O[C@@H](C)C5)cc4)oc3c2)[C@H]1C CHEMBL3932982 EC50 46.0 nM
CC(C)(C)OC(=O)N1CCC2(CCc3cc(-c4ccc(CS(=O)(=O)Cc5ccccn5)cc4)ccc3O2)CC1 CHEMBL4294852 EC50 46.0 nM
Cc1nc(S(C)(=O)=O)ccc1Nc1ncnc(OC2CCN(C(=O)OC(C)C)CC2)c1C(F)F CHEMBL1951030 EC50 47.0 nM
CCc1cnc(OC(=O)N2CCC(n3cc(CNc4ccc(S(C)(=O)=O)cc4F)cn3)CC2)nc1 CHEMBL2313409 EC50 47.0 nM
CC(C)(C)OC(=O)N1CCC(O[C@H]2CC[C@H](Oc3ccc(S(C)(=O)=O)cn3)CC2)CC1 CHEMBL3598086 EC50 47.0 nM
CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(OC[C@@H]4CCCN4C(=O)OC(C)(C)C)cc3)oc2c1 CHEMBL3918355 EC50 47.0 nM
CC(C)OC(=O)N1CCC2(CC1)CC(CCCOc1ccc(C(=O)NC3CC3)nc1)C2 CHEMBL4227426 EC50 47.0 nM
CS(=O)(=O)c1ccc(N2CCC(C3CCN(c4ccc(Cl)cn4)CC3)CC2)cc1 CHEMBL1771088 EC50 48.0 nM
CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3cncc(C#N)c3)cc2)C2CC2)CC1 CHEMBL3904060 EC50 48.0 nM
CC(C)OC(=O)N1CCC2(CC1)CC(CCCOc1ccc(C(=O)NCC(N)=O)c(F)c1)C2 CHEMBL4227435 EC50 48.0 nM
CC(C)c1noc(N2CCC(Oc3cc(N4CCc5cc(C6CCCCC6=O)ccc54)ncn3)CC2)n1 CHEMBL4780567 EC50 48.0 nM
CC(C)c1noc(N2CCC(Oc3cc(N4CCc5cc([S+]([O-])CCO)ccc54)ncn3)CC2)n1 CHEMBL4790055 EC50 48.0 nM
CC(C)(C)OC(=O)N1CC2CC1CC2Nc1ncnc(Nc2ccc(S(C)(=O)=O)cc2)c1[N+](=O)[O-] CHEMBL4067384 EC50 48.2 nM
CS(=O)(=O)c1cnc(O[C@H]2CC[C@H](OC3CCN(CC4(C(F)(F)F)CCCC4)CC3)CC2)cn1 CHEMBL3598110 EC50 48.8 nM
CCc1c(Oc2cccnc2C)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC1(C)CC1 CHEMBL2312505 EC50 49.0 nM
CC(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3ccncc3C#N)cc2)C2CC2)CC1 CHEMBL3979128 EC50 49.0 nM
COCC1(OC(=O)N2CC3COCC(C2)C3Oc2ncnc(Nc3ccc(C#N)cc3F)c2F)CC1 CHEMBL4166451 EC50 49.0 nM
CCc1cnc(N2CCC(c3nc(COc4ccc(/C=C5\CC(=O)NC5=O)cc4F)cs3)CC2)nc1 CHEMBL4218430 EC50 49.0 nM
CC(C)(C)OC(=O)N1C[C@@H]2CC[C@H]1C[C@@H]2Nc1ncnc2c(Nc3ccc(C#N)cc3F)ncnc12 CHEMBL4239711 EC50 49.0 nM
CCOC(=O)C1CCN(c2ncnc(Oc3ccc(Br)cc3)c2[N+](=O)[O-])CC1 CHEMBL487639 IC50 50.0 nM
Cc1c(Oc2ccc(Cl)cc2C#N)ncnc1O[C@H]1C[C@H]2CC[C@@H](C1)N2S(=O)(=O)C1CC1 CHEMBL3084384 EC50 50.0 nM
CCc1c(Nc2ccc(S(C)(=O)=O)nc2C)ncnc1OC1CCN(C(=O)OC(C)C)CC1 CHEMBL1951028 EC50 50.0 nM
CCOC(=O)c1cc(C)nc(Oc2cccc(NS(=O)(=O)c3ccc(Cl)cc3)c2)c1 CHEMBL2391592 EC50 50.0 nM
O=S(=O)(c1ccc(Cl)cc1)N1CCCc2ccc(Oc3cc(-c4nc(C5CC5)no4)cc(Cl)n3)cc21 CHEMBL3113002 EC50 50.0 nM
CC(C)c1noc(-c2cc(Cl)nc(Oc3ccc4c(c3)N(S(=O)(=O)c3ccc(Cl)cc3)CCC4)c2)n1 CHEMBL3113001 EC50 50.0 nM
CC(C)(C)c1noc(-c2cc(Cl)nc(Oc3ccc4c(c3)N(S(=O)(=O)c3ccc(Cl)cc3)CCC4)c2)n1 CHEMBL3112985 EC50 50.0 nM
CCC1OC(=O)NN=C1N1CCc2nc(-c3ccccc3)oc2C1 CHEMBL3978218 EC50 50.0 nM
CC(C)OC(=O)N1CCC(Oc2ncnc3c2CCN3c2ccc([S@+](C)[O-])c(F)c2)CC1 CHEMBL2448136 pEC50 50.12 nM
CC(C)c1noc(N2CCC(O)CC2)n1 CHEMBL2177769 pEC50 50.12 nM
CCCCOC(=O)N1CCC(Oc2ncnc3c2CCN3c2ccc(S(C)(=O)=O)cc2F)CC1 CHEMBL2181693 pEC50 50.12 nM
CC(C)OC(=O)N1CCC(Oc2ncnc3c2CCN3c2ccc(S(C)(=O)=O)cc2F)CC1 CHEMBL2177777 pEC50 50.12 nM
CCc1cnc(N2CCC(CCCNc3ccc4c(c3)C(=O)CC4)CC2)nc1 CHEMBL2058673 EC50 51.0 nM
CNC(=O)C1CCN(c2nc(-c3cc(F)c(Cl)cc3F)nc3c2CS(=O)(=O)C3)CC1 CHEMBL2158450 EC 51.0 nM
CCCS(=O)(=O)N1CC=C(c2ccc3c(c2)CC(C2CCN(C(=O)OC4CCCCC4)CC2)O3)CC1 CHEMBL3261125 EC50 51.0 nM
Cc1c(Nc2ccc(C#N)cc2Cl)ncnc1OC1C2COCC1CN(S(=O)(=O)C1CC1)C2 CHEMBL3629480 EC50 51.0 nM
CS(=O)(=O)c1ccc(-c2cc3cc(C4CCN(CC5(C(F)(F)F)CC5)CC4)oc3cn2)c(F)c1 CHEMBL3719228 EC50 51.0 nM
CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(OCC4CCN(C(=O)OC(C)(C)C)CC4)cc3)oc2c1 CHEMBL3892506 EC50 51.0 nM
CC[C@@H]1CC(=O)NN=C1c1ccc2nc(-c3ccc(OC4CCOCC4)cc3)oc2c1 CHEMBL4106479 EC50 51.0 nM
CCNC(=O)c1ccc(-c2ccc(C(=O)N(C3CC3)C3CCN(C(=O)OC(C)(C)C)CC3)cc2)cc1 CHEMBL3948147 EC50 51.0 nM
CC(C)(C)OC(=O)N1CCC(N(CC2CC2)c2cc(N3CCc4cc(S(C)(=O)=O)ccc43)ncn2)CC1 CHEMBL4858330 EC50 51.0 nM
CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3c(c2)OCC3=O)CC1 CHEMBL2058400 EC50 52.0 nM
CC(C)(C)OC(=O)N1CCC(O[C@H]2CC[C@H](Oc3ccc(S(C)(=O)=O)c(F)c3)CC2)CC1 CHEMBL3598084 EC50 52.0 nM
CC(C)OC(=O)N1CCC(n2ncc3cc(-c4cc(F)c(C(N)=O)cc4F)ncc32)CC1 CHEMBL3823398 EC50 52.0 nM
CCC[C@@H]1C(=O)NN=C(c2ccc3nc(-c4ccc(OCc5ccccc5)cc4)oc3c2)[C@H]1C CHEMBL3895341 EC50 52.0 nM
CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(OC[C@H]4CCCN4C(=O)OC(C)(C)C)cc3)oc2c1 CHEMBL4115415 EC50 52.0 nM
CC1(OC(=O)N2CCC(N(C(=O)c3ccc(-c4cnco4)cc3)C3CC3)CC2)CC1 CHEMBL3933770 EC50 52.0 nM
CC(C)OC(=O)N1CCC2(CC1)CC(CCCOc1ccc(C(N)=O)c(F)c1)C2 CHEMBL4228188 EC50 52.0 nM
CN(C(=O)Cc1ccc(-n2cnnn2)cc1)C1CCN(Cc2ccc(C(F)(F)F)c(F)c2)CC1 CHEMBL2010840 EC50 53.0 nM
CCOC(=O)C(C)(Cc1ccccc1)c1csc2c(-c3ccc(Cl)cc3)cnn12 CHEMBL3260542 EC50 53.0 nM
CCC[C@@H]1C(=O)NN=C(c2ccc3nc(-c4ccc(OCCN(C(C)C)C(C)C)cc4)oc3c2)[C@H]1C CHEMBL3905505 EC50 53.0 nM
CCC[C@H]1C(=O)NN=C(c2ccc3nc(-c4ccc(C)s4)oc3c2)[C@@H]1C CHEMBL4108252 EC50 53.0 nM
CC(C)(C)OC(=O)N1CC2CC(Nc3ncnc(Nc4ccc(S(C)(=O)=O)cc4F)c3[N+](=O)[O-])C1C2 CHEMBL4078851 EC50 53.0 nM
CC(C)(C)OC(=O)N1CCC(c2coc3c(N4CCc5cc(S(C)(=O)=O)ccc54)ncnc23)CC1 CHEMBL4099307 EC50 53.0 nM
CON(C)C(=O)c1ccc(-c2csc3c(N(C)C4CCN(C(=O)OC(C)(C)C)CC4)ncnc23)cc1F CHEMBL4105014 EC50 53.0 nM
Cc1ncccc1Nc1ncnc(O[C@H]2C[C@H]3CC[C@@H](C2)N3S(=O)(=O)C2CC2)c1C CHEMBL3084385 EC50 54.0 nM
C[C@@H]1CN(C(=O)OC(C)(C)C#N)CCN1c1ncc(OCc2ccncc2C#N)cn1 CHEMBL2086686 EC50 54.0 nM
C[C@H]1CN(c2ncc(OCc3ccc(S(C)(=O)=O)cc3)cn2)CCN1C(=O)OC(C)(C)C CHEMBL2086662 EC50 54.0 nM
C[C@@H]1CN(c2ncc(OCc3ccc(S(C)(=O)=O)cc3)cn2)CCN1C(=O)OC(C)(C)C CHEMBL2086661 EC50 54.0 nM
C[C@@H](OC(=O)N1CCC2(CCc3cc(-c4ccc(CS(=O)(=O)Cc5ccccn5)cc4)ccc3O2)CC1)C(F)(F)F CHEMBL3809509 EC50 54.0 nM
CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(OCCN4C[C@@H](C)O[C@@H](C)C4)cc3)oc2c1 CHEMBL3971716 EC50 54.0 nM
CS(=O)(=O)c1cnc(O[C@H]2CC[C@H](OC3CCN(CC4(C(F)(F)F)CCC4)CC3)CC2)cn1 CHEMBL3598109 EC50 54.8 nM
C[C@@H]1CN(c2nnc(C(F)(F)F)o2)CCN1c1ncc(OCc2ccc(S(C)(=O)=O)cc2C#N)cn1 CHEMBL3357995 EC50 55.0 nM
COc1ncc(-c2ccc(C(=O)N(C3CC3)C3CCN(C(=O)OC(C)(C)C)CC3)cc2)cn1 CHEMBL3918525 EC50 55.0 nM
CC(C)(C)OC(=O)N1CCC2(CCC(CCOc3ccc(S(C)(=O)=O)cc3)CC2)CC1 CHEMBL4227805 EC50 55.0 nM
CCC[C@@H]1C(=O)NN=C(c2ccc3nc(-c4ccccc4)oc3c2)[C@H]1C CHEMBL3901814 EC50 56.0 nM
CC(C)(C)OC(=O)N1CCC2(CCc3cc(-c4ccc(CS(=O)(=O)Cc5ccccc5)cc4)ccc3O2)CC1 CHEMBL4283180 EC50 56.0 nM
Cc1cnc(N2CCC(C3CCN(c4ccc(S(C)(=O)=O)cc4)CC3)CC2)nc1 CHEMBL1771086 EC50 57.0 nM
Fc1cc(-c2nc3c(c(N4CCOCC4)n2)SCC3)c(F)cc1Cl CHEMBL2158461 EC 57.0 nM
CC(C)OC(=O)N1CCC(CO[C@H]2CC[C@H](c3ccc(S(C)(=O)=O)cc3)CC2)CC1 CHEMBL2323597 EC50 57.0 nM
CCc1cnc(N2CCC(Oc3ccn(-c4ccc(S(C)(=O)=O)cc4)c(=O)c3)CC2)nc1 CHEMBL3338169 EC50 57.0 nM
CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3ccc(CS(C)(=O)=O)cc3)cc2)C2CC2)CC1 CHEMBL3891199 EC50 57.0 nM
CON(C)C(=O)c1ccc(-c2csc3c(OC4CCN(C(=O)OC(C)(C)C)CC4)ncnc23)cc1F CHEMBL4099911 EC50 57.0 nM
N#Cc1cc(N2CC[C@@H](Oc3ccc(OCC4CC4)nc3)C2=O)cnc1N1CC(O)C1 CHEMBL4537090 EC50 57.0 nM
CC(C)c1noc(N2CCC(CCCNc3ccc4c(c3)C(=O)CC4)CC2)n1 CHEMBL2058674 EC50 58.0 nM
CCOC(=O)C(C)(Cc1ccccc1)c1ccnc2c(-c3ccc(Cl)nc3)cnn12 CHEMBL3260531 EC50 58.0 nM
C[C@@H]1CN(c2nnc(C(F)(F)F)o2)CCN1c1ncc(OCc2ccc(C[S+](C)[O-])cc2F)cn1 CHEMBL3358003 EC50 58.0 nM
CC(C)(C)OC(=O)N1CCC(c2cc3cc(-c4ccc(S(C)(=O)=O)cc4)ncc3o2)CC1 CHEMBL3716247 EC50 58.0 nM
CC1CC(=O)NN=C1c1ccc2nc(-c3ccc(OCc4ccccc4)cc3)oc2c1 CHEMBL3983527 EC50 58.0 nM
CCCN(CCOc1ccc(-c2nc3ccc(C4=NNC(=O)CC4CC)cc3o2)cc1)C(C)C CHEMBL3935285 EC50 58.0 nM
CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(OC(C)C)cc3)oc2c1 CHEMBL3962398 EC50 59.0 nM
O=C(OC1CCCCC1)N1CCC(N(C(=O)c2ccc(-c3cnco3)cc2)C2CC2)CC1 CHEMBL3937113 EC50 59.0 nM
Cc1c(Oc2ccc(S(C)(=O)=O)cc2F)ncnc1O[C@H]1CC[C@]2(CC1)COC(C)(C)C2 CHEMBL4463622 EC50 59.0 nM
Cc1cc(S(C)(=O)=O)ncc1Oc1ncnc(OC2CCN(C(=O)OC(C)C)CC2)c1C CHEMBL1951024 EC50 60.0 nM
Cc1nc(S(C)(=O)=O)ccc1Nc1ncnc(OC2CCN(C(=O)OC(C)C)CC2)c1C1CC1 CHEMBL1951029 EC50 60.0 nM
O=S(=O)(c1ccc(Cl)cc1)N1CCOc2cc(Cl)c(Oc3cc(-c4nc(C5CC5)no4)cc(Cl)n3)cc21 CHEMBL3112994 EC50 60.0 nM
O=S(=O)(c1ccc(Cl)cc1)N1CCCc2ccc(Oc3cc(-c4nc(CC5CC5)no4)cc(Cl)n3)cc21 CHEMBL3112984 EC50 60.0 nM
O=S(=O)(c1ccc(Cl)cc1)N1CCc2ccc(Oc3cc(-c4nc(C5CC5)no4)cc(Cl)n3)cc21 CHEMBL3113000 EC50 60.0 nM
CCCc1cnc(N2CCC(C3Cc4cc(C5=CCN(S(=O)(=O)CCCCO)CC5)cc(F)c4O3)CC2)nc1 CHEMBL3261139 EC50 60.0 nM
CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(OC4CCN(C(=O)OC(C)(C)C)CC4)cc3)oc2c1 CHEMBL3929405 EC50 60.0 nM
CCNC(=O)c1ccc(-c2cc3nnn(C4CCN(c5ncc(CC)cn5)CC4)c3cn2)c(C(F)(F)F)c1 CHEMBL4072376 EC50 60.0 nM
Cc1ncccc1Oc1ncnc(O[C@H]2C[C@H]3CC[C@@H](C2)N3C(=O)OCC(F)(F)F)c1C CHEMBL3084367 EC50 61.0 nM
CCC1OC(=O)NN=C1c1ccc2nc(-c3ccccc3)oc2c1 CHEMBL3901563 EC50 61.0 nM
CC(C)OC(=O)N1CCC(n2nnc3cc(-c4cc(F)c(C(=O)N5CCC5)cc4F)ncc32)CC1 CHEMBL4068495 EC50 61.0 nM
CS(=O)(=O)c1ccc(N2CCC(C3CCN(c4ccc(C#N)cn4)CC3)CC2)cc1 CHEMBL1771091 EC50 62.0 nM
Cc1ncccc1Oc1ncnc(O[C@H]2C[C@@H]3CC(F)(F)[C@@H](C2)N3S(=O)(=O)C2CC2)c1C CHEMBL1778255 EC50 62.0 nM
CCOC(=O)C(C)(Cc1ccccc1)c1ccnc2c(-c3ccc(Cl)cc3)ncn12 CHEMBL3260541 EC50 62.0 nM
CCCc1cnc(N2CCC(C3Cc4cc(C5=CCN(S(=O)(=O)CCC)CC5)cc(F)c4O3)CC2)nc1 CHEMBL3261135 EC50 62.0 nM
CC(C)(C)OC(=O)N1CCC(c2cc3cc(-c4ccc(S(C)(=O)=O)c(F)c4)ncc3o2)CC1 CHEMBL3716518 EC50 62.0 nM
CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(OCCN4CCSCC4)cc3)oc2c1 CHEMBL3964608 EC50 62.0 nM
CC(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3cnco3)cc2)C2CC2)CC1 CHEMBL3949822 EC50 62.0 nM
CS(=O)(=O)c1cnc(O[C@H]2CC[C@H](OC3CCN(CC4(C(F)(F)F)CC4)CC3)CC2)cn1 CHEMBL3598108 EC50 62.6 nM
C[C@@H]1CN(c2ncc(F)cn2)CCN1c1ncc(OCc2ccncc2C#N)cn1 CHEMBL2086689 EC50 63.0 nM
CC(C)(C)OC(=O)N1CCN(c2ncc(OCc3ccncc3F)cn2)CC1 CHEMBL2086679 EC50 63.0 nM
CC(C)(C)OC(=O)N1CCC(CO[C@H]2CC[C@H](c3ccncc3F)CC2)CC1 CHEMBL2323602 EC50 63.0 nM
CCOC(=O)C(C)(CC1CCOCC1)c1ccnc2c(-c3ccc(Cl)cc3)cnn12 CHEMBL3260525 EC50 63.0 nM
CCCc1cnc(N2CCC(Oc3ccn(-c4ccc(-n5cncn5)cc4)c(=O)c3)CC2)nc1 CHEMBL3338179 EC50 63.0 nM
CC(C)(C)OC(=O)N1CCC(n2nnc3cc(-c4ccc(S(C)(=O)=O)cc4)ccc32)CC1 CHEMBL3823123 EC50 63.0 nM
CC(C)OC(=O)N1CCC2(CC1)CC(CCCOc1ccc(C(=O)NC3CC3)cn1)C2 CHEMBL4228417 EC50 63.0 nM
CC(C)OC(=O)N1CCC(Oc2ncnc3c2CCN3c2ccc(C#N)cc2F)CC1 CHEMBL2177782 pEC50 63.1 nM
C[C@@H]1CN(c2noc(C3(C)COC3)n2)CCN1c1ncc(OCc2ccncc2C#N)cn1 CHEMBL3220032 pEC50 63.1 nM
C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H](C)N1c1ncc(OCc2ccc(S(C)(=O)=O)cc2)cn1 CHEMBL2086664 EC50 64.0 nM
CCc1cnc(N2CCC(c3cc4cc(-c5ccc(S(C)(=O)=O)cc5F)ncc4o3)CC2)nc1 CHEMBL3715162 EC50 64.0 nM
CON(C)C(=O)c1ccc(-c2csc3c(OC4CCN(C(=O)OC(C)(C)C)CC4)ncnc23)cc1 CHEMBL4087235 EC50 64.0 nM
C[C@@H](O[C@H]1CC[C@]2(CC1)COC(C)(C)C2)c1nc(-c2cc(F)c(CS(C)(=O)=O)cc2F)no1 CHEMBL4440715 EC50 64.0 nM
CC(C)(C)OC(=O)N1CCN(c2ncc(OCc3ccc(S(C)(=O)=O)cc3)cn2)CC1 CHEMBL2086650 EC50 65.0 nM
Cc1ncccc1Nc1ncnc(OC2C3COCC2CN(C(=O)OC(C)C)C3)c1C CHEMBL3629482 EC50 65.0 nM
CC(C)OC(=O)N1CCC(n2nnc3cc(-c4cc(F)c(C(=O)N5CCCC5)cc4F)ncc32)CC1 CHEMBL4089628 EC50 65.0 nM
CC(C)OC(=O)N1CCC(n2ncc3ccc(-c4cc(F)c(S(C)(=O)=O)cc4F)nc32)CC1 CHEMBL5188902 EC50 65.0 nM
CS(=O)(=O)c1cnc(O[C@H]2CC[C@H](OC3CCN(C(=O)OC(CF)CF)CC3)CC2)cn1 CHEMBL3598098 EC50 65.1 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)OC(C)F)CC2)c1F CHEMBL3325849 EC50 65.5 nM
CC[C@@H]1CC(=O)NN=C1c1ccc2nc(-c3ccccc3)oc2c1 CHEMBL4114216 EC50 66.0 nM
COC(=O)c1ccc(-c2ccc(C(=O)N(C3CC3)C3CCN(C(=O)OC(C)(C)C)CC3)cc2)cn1 CHEMBL3933838 EC50 66.0 nM
CCCS(=O)(=O)N1CC=C(c2ccc3c(c2)CC(C2CCN(c4ncc(C5CC5)cn4)CC2)O3)CC1 CHEMBL3261128 EC50 67.0 nM
CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(Oc4ccccc4)cc3)oc2c1 CHEMBL3913898 EC50 67.0 nM
NC(=O)Cc1ccc(OCC[C@@H]2C[C@@H]2C2CCN(c3ncc(Cl)cn3)CC2)cc1 CHEMBL4089040 EC50 67.0 nM
CON(C)C(=O)c1ccc(-c2csc3c(N(C)C4CCN(C(=O)OC(C)C)CC4)ncnc23)cc1F CHEMBL4097314 EC50 67.0 nM
CC(C)OC(=O)N1CCC2(CC1)CC(CCCOc1ccc(C(=O)N(C)C3CC3)c(F)c1)C2 CHEMBL4225589 EC50 67.0 nM
O=S(=O)(Nc1cccc(Oc2cc(-c3nccs3)cc(Cl)n2)c1)c1ccc(Cl)cc1 CHEMBL2391597 EC50 68.0 nM
CC(C)(C)OC(=O)N1CCC(CCOC(=O)N2CCc3cc(S(C)(=O)=O)ccc32)CC1 CHEMBL3113626 EC50 68.0 nM
CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3ccc(CO)cc3)cc2)C2CC2)CC1 CHEMBL3939845 EC50 68.0 nM
CC(C)(C)OC(=O)N1CCC2(CCc3cc(-c4ccc(CS(=O)(=O)Cc5cccnc5)cc4)ccc3O2)CC1 CHEMBL4287616 EC50 68.0 nM
Cc1cc2c(c(Oc3cccc(NS(=O)(=O)c4ccc(Cl)cc4)c3)n1)C(=O)N(C1CCCC1)C2=O CHEMBL3104894 EC50 69.0 nM
CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(OCC(C)(C)N4CCOCC4)cc3)oc2c1 CHEMBL3910893 EC50 69.0 nM
CC(O[C@H]1CC[C@]2(CC1)COC(C)(C)C2)c1nc(-c2ccc(CC(=O)N(C)C)c(F)c2)no1 CHEMBL4476507 EC50 69.0 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=S)OC(C)C)CC2)c1F CHEMBL3326677 EC50 69.9 nM
O=S(=O)(c1ccc(Cl)cc1)N1CCCc2cc(F)c(Oc3cc(-c4nnc(C5CC5)o4)cc(Cl)n3)cc21 CHEMBL3112992 EC50 70.0 nM
O=S(=O)(c1ccc(Cl)c(Cl)c1)N1CCCc2ccc(Oc3cc(-c4nc(C5CC5)no4)cc(Cl)n3)cc21 CHEMBL3113018 EC50 70.0 nM
CCCc1cnc(N2CCC(C3(C)Cc4cc(C5=CCN(S(=O)(=O)CCC)CC5)ccc4O3)CC2)nc1 CHEMBL3261137 EC50 70.0 nM
Cc1c(Nc2ccc(S(C)(=O)=O)cc2F)ncnc1OC1CC2COCC(C1)N2C(=O)OC1(C)CC1 CHEMBL3629483 EC50 70.0 nM
CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(OCc4ccccc4)cc3)oc2c1 CHEMBL3973628 EC50 70.0 nM
CCc1cnc(N2CCC(n3ncc4cc(-c5ccc(S(C)(=O)=O)cc5)c(C)cc43)CC2)nc1 CHEMBL4080747 EC50 70.0 nM
CCc1cnc(N2CC=C(c3nc(COc4ccc(S(C)(=O)=O)cc4)cs3)CC2)nc1 CHEMBL4639029 EC50 70.5 nM
Cc1nc(S(C)(=O)=O)ccc1Nc1ncnc(OC2CCN(C(=O)OC(C)C)CC2)c1OC(C)C CHEMBL1951034 EC50 71.0 nM
COc1ccc(OC(=O)N2CCC(N(C(=O)c3ccc(-c4cnco4)cc3)C3CC3)CC2)cc1 CHEMBL3959648 EC50 71.0 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)C3CCCC3)CC2)c1F CHEMBL3326683 EC50 72.8 nM
CC(C)c1noc(N2CCC(CCCNc3ccc4c(c3)OCC4=O)CC2)n1 CHEMBL2058669 EC50 73.0 nM
CCOC(=O)C(C)(Cc1cccnc1)c1ccnc2c(-c3ccc(Cl)cc3)cnn12 CHEMBL3260526 EC50 73.0 nM
COC(=O)[C@@]1(Cc2cccc(F)c2)N=Cc2cnc3c(-c4ccc(C(F)(F)F)cc4)cnn3c21 CHEMBL3354793 EC50 73.0 nM
CC(C)(C)OC(=O)N1CCC(C)(c2cc3cc(C4=CCN(S(C)(=O)=O)CC4)ncc3o2)CC1 CHEMBL3719377 EC50 73.0 nM
CC[C@@H]1CC(=O)NN=C1c1ccc2nc(-c3ccc(OCC(C)N4CCCCC4)cc3)oc2c1 CHEMBL4115122 EC50 73.0 nM
CON(C)C(=O)c1ccc(-c2ccc(OCC3CCN(C(=O)OC(C)(C)C)CC3)cn2)cc1F CHEMBL4061666 EC50 73.0 nM
CN(C(=O)Cc1ccc(-n2cnnn2)cc1)C1CCN(Cc2ccc(C(F)(F)F)cc2)CC1 CHEMBL2010836 EC50 74.0 nM
COC(=O)C1(Cc2ccccc2)CCCCc2cnc3c(-c4ccc(C(F)(F)F)cc4)cnn3c21 CHEMBL3354782 EC50 74.0 nM
CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3ccc(S(C)(=O)=O)cn3)cc2)C2CC2)CC1 CHEMBL3911326 EC50 74.0 nM
CC(CNC(=O)Cc1cccc(F)c1F)C1CCN(C(=O)OC(C)(C)C)CC1 CHEMBL1684031 EC50 75.0 nM
Cc1cnccc1COc1cnc(N2CCN(C(=O)OC(C)(C)C)CC2)nc1 CHEMBL2086677 EC50 75.0 nM
Cc1ncccc1Oc1ncnc(N2C3CC4CC2CC(C3)N4C(=O)OC2(C)CCC2)c1C CHEMBL2312528 EC50 75.0 nM
Cc1ncoc1-c1ccc(C(=O)N(C2CC2)C2CCN(C(=O)OC(C)(C)C)CC2)cc1 CHEMBL3933773 EC50 75.0 nM
CCOC(=O)c1cnn(-c2ccc(C(=O)N(C3CC3)C3CCN(C(=O)OC(C)(C)C)CC3)cc2)c1C CHEMBL3920834 EC50 75.0 nM
CC(=O)N(C)c1ccc2c(c1)CCN2c1cc(OC2CCN(c3nc(C(C)C)no3)CC2)ncn1 CHEMBL4755582 EC50 75.0 nM
Cc1c(Oc2ccc(/C=C3\SC(=O)NC3=O)cc2)ncnc1OC1CCN(C(=O)OCC(C)C)CC1 CHEMBL4748865 EC50 75.1 nM
CC(C)(C)OC(=O)N1CCC(C2CCN(c3ccc(C(N)=O)cc3)CC2)CC1 CHEMBL1771073 EC50 76.0 nM
CN(C(=O)Cc1ccc(-n2cnnn2)cc1)C1CCN(Cc2nc3cc(F)ccc3s2)CC1 CHEMBL2010842 EC50 76.0 nM
CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(OCCN4C(C)(C)CCCC4(C)C)cc3)oc2c1 CHEMBL3900433 EC50 76.0 nM
Cc1ccc(-c2ccc(C(=O)N(C3CC3)C3CCN(C(=O)OC(C)(C)C)CC3)cc2)nn1 CHEMBL3903985 EC50 76.0 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)C(C)(C)F)CC2)c1F CHEMBL3325461 EC50 76.3 nM
CCc1cnc(N2CCC(COc3ccc(-c4ccc(C(=O)N(C)OC)c(F)c4)nc3)CC2)nc1 CHEMBL4089778 EC50 77.0 nM
CC(C)(C)OC(=O)N1CC2CC(Oc3ncnc(Nc4ccc(S(C)(=O)=O)cc4F)c3[N+](=O)[O-])C1C2 CHEMBL4095373 EC50 77.7 nM
CC(CNC(=O)Cc1cc(F)ccc1F)C1CCN(C(=O)OC(C)(C)C)CC1 CHEMBL1684032 EC50 78.0 nM
CC(C)(C)OC(=O)N1CCN(c2ncc(-c3ccc(OCC#N)cc3)cn2)CC1 CHEMBL2086649 EC50 78.0 nM
CCCS(=O)(=O)N1CC=C(c2ccc3c(c2)CC(C2CCN(c4ncc(Cl)cn4)CC2)O3)CC1 CHEMBL3261126 EC50 78.0 nM
CCCc1cnc(N2CCC(C3(C)Cc4cc(C5=CCN(S(=O)(=O)CCCO)CC5)ccc4O3)CC2)nc1 CHEMBL3261142 EC50 78.0 nM
CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3ccc(C#N)c(F)c3)cc2)C2CC2)CC1 CHEMBL3911390 EC50 78.0 nM
CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3cnco3)c([N+](=O)[O-])c2)C2CC2)CC1 CHEMBL3967234 EC50 78.0 nM
CC(=O)c1cnc(N2CCC(c3coc4c(N5CCc6cc(S(C)(=O)=O)ccc65)ncnc34)CC2)nc1 CHEMBL4104336 EC50 78.0 nM
CC(C)(C)OC(=O)N1CCC(CCCCCCOc2ccc(S(C)(=O)=O)cc2)CC1 CHEMBL4205488 EC50 78.0 nM
CC(C)OC(=O)N1CCC2(CC1)CC(CCCOc1ccc(S(C)(=O)=O)cc1)C2 CHEMBL4225934 EC50 78.0 nM
C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1c1ncc(OCc2ccc(S(=O)(=O)N(C)C)cc2)cn1 CHEMBL2086669 EC50 79.0 nM
CC(C)(C)OC(=O)N1CC2CCC(C1)N2c1ncc(OCc2ccc(S(C)(=O)=O)cc2)cn1 CHEMBL2382408 EC50 79.0 nM
CC(C)(F)CN1CCC(c2cc3cc(-c4ccc(S(C)(=O)=O)cc4F)ncc3o2)CC1 CHEMBL3715018 EC50 79.0 nM
CC[C@H]1C(c2ccc3nc(-c4ccccc4)oc3c2)=NNC(=O)[C@@H]1C CHEMBL4111022 EC50 79.0 nM
CC[C@@H]1CC(=O)NN=C1c1ccc2nc(-c3ccc(OC)cc3)oc2c1 CHEMBL4113382 EC50 79.0 nM
CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3ccc(NS(C)(=O)=O)cc3)cc2)C2CC2)CC1 CHEMBL3923095 EC50 79.0 nM
CC(C)(C)OC(=O)N1CCC(c2csc3c(Nc4ccc(S(C)(=O)=O)cc4F)ncnc23)CC1 CHEMBL4100997 EC50 79.0 nM
CC(C)OC(=O)N1CCC(Sc2ncnc3c2CCN3c2ccc(S(C)(=O)=O)cc2F)CC1 CHEMBL2181678 pEC50 79.43 nM
CC(C)c1noc(N2CCC(Oc3ncnc4c3CCN4c3ccc(S(C)(=O)=O)cc3F)CC2)n1 CHEMBL2177770 pEC50 79.43 nM
CCCOC(=O)N1CCC(Oc2ncnc3c2CCN3c2ccc(S(C)(=O)=O)cc2F)CC1 CHEMBL2181692 pEC50 79.43 nM
CC(C)OC(=O)N1CCC(Oc2ncnc3c2CCN3c2ccc(-c3nccs3)cc2F)CC1 CHEMBL2177783 pEC50 79.43 nM
CC1(OC(=O)N2CCC([C@H](F)CNC(=O)Cc3c(F)ccc(F)c3F)CC2)CC1 CHEMBL1683943 EC50 80.0 nM
O=S(=O)(c1ccc(Cl)cc1)N1CCCc2cc(Cl)c(Oc3cc(-c4nnc(C5CC5)o4)cc(Cl)n3)cc21 CHEMBL3112993 EC50 80.0 nM
O=S(=O)(c1ccc(Cl)cc1)N1CCCc2cc(Cl)c(Oc3cc(-c4nc(C5CC5)no4)cc(Cl)n3)cc21 CHEMBL3112991 EC50 80.0 nM
O=S(=O)(c1ccc(Cl)cc1)N1CCCc2ccc(Oc3cc(-c4nnc(C5CC5)o4)cc(Cl)n3)cc21 CHEMBL3112987 EC50 80.0 nM
CCc1noc(-c2cc(Cl)nc(Oc3ccc4c(c3)N(S(=O)(=O)c3ccc(Cl)cc3)CCC4)c2)n1 CHEMBL3112982 EC50 80.0 nM
Cc1ccc(S(=O)(=O)N2CCCc3ccc(Oc4cc(-c5nc(C6CC6)no5)cc(Cl)n4)cc32)cc1 CHEMBL3113015 EC50 80.0 nM
CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(OC4CCOCC4)cc3)oc2c1 CHEMBL3907178 EC50 80.0 nM
CCCOC(=O)N1CCC(N(C(=O)c2ccc(-c3cnco3)cc2)C2CC2)CC1 CHEMBL3904656 EC50 80.0 nM
Cc1cc(C(=O)N(C2CC2)C2CCN(C(=O)OC(C)(C)C)CC2)ccc1-c1cnco1 CHEMBL3948064 EC50 81.0 nM
CC(C)OC(=O)N1CCC(Oc2cc(Oc3ccc(S(C)(=O)=O)cc3F)ncn2)CC1 CHEMBL1778140 EC50 82.0 nM
CCCc1cnc(N2CCC(C3Cc4cc(C5=CCN(S(=O)(=O)CCC)CC5)ccc4O3)CC2)nc1 CHEMBL3261130 EC50 82.0 nM
CC(C)OC(=O)N1CCC(N(C)c2ncnc3c(-c4ccc(S(C)(=O)=O)cc4)csc23)CC1 CHEMBL3321830 EC50 82.0 nM
CC(C)(C)OC(=O)N1CCC(c2cc3cc(N4CCN(S(C)(=O)=O)CC4)ncc3o2)CC1 CHEMBL3715273 EC50 82.0 nM
C[C@@H]1CC(=O)NN=C1c1ccc2nc(-c3ccccc3)oc2c1 CHEMBL4107942 EC50 82.0 nM
CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(OC4CCCC4)cc3)oc2c1 CHEMBL3941257 EC50 82.0 nM
CCCc1cnc(N2CCC(n3nnc4c(Nc5ccc(S(C)(=O)=O)cc5F)ncnc43)CC2)nc1 CHEMBL4080356 EC50 82.0 nM
CCc1cnc(N2CCC(c3nc(COc4ccc(/C=C5\CC(=O)N(c6ccccc6)C5=O)cc4F)cs3)CC2)nc1 CHEMBL4214024 EC50 82.0 nM
CC(C)N(C)C(=O)C1CN(c2ncc(N3CC[C@@H](Oc4ccc(OCC(F)(F)F)nc4)C3=O)cn2)C1 CHEMBL4592996 EC50 82.0 nM
CCc1cnc(N2CCC(N3Cc4cn(-c5ccc(S(C)(=O)=O)cc5F)nc4C3)CC2)nc1 CHEMBL2313412 EC50 83.0 nM
CCC[C@H]1C(=O)NN=C(c2ccc3nc(-c4ccco4)oc3c2)[C@@H]1C CHEMBL4109181 EC50 83.0 nM
CCNC(=O)c1cc(C)c(-c2cc3nnn(C4CCN(c5ncc(CC)cn5)CC4)c3cn2)c(C)c1 CHEMBL4100021 EC50 83.0 nM
CN(c1ncnc2c(-c3ccc(C(=O)NOCc4ccccc4)cc3)csc12)C1CCN(C(=O)OC(C)(C)C)CC1 CHEMBL4078440 EC50 83.0 nM
CCOC(=O)C1CCN(c2ncnc(Oc3cc(C(F)(F)F)nn3C)c2[N+](=O)[O-])CC1 CHEMBL461765 IC50 84.0 nM
CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(OCCN4CC(C)OC(C)C4)cc3)oc2c1 CHEMBL3935045 EC50 84.0 nM
CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3ccc(C#N)cc3)cc2)C2CC2)CC1 CHEMBL3908102 EC50 84.0 nM
Cc1noc(C)c1-c1ccc(C(=O)N(C2CC2)C2CCN(C(=O)OC(C)(C)C)CC2)cc1 CHEMBL3936640 EC50 85.0 nM
CC1(C)C[C@]2(CC[C@H](c3nc(COc4ccc(-n5cnnn5)cc4)cs3)CC2)CO1 CHEMBL4453416 EC50 85.0 nM
Cc1c(Nc2ccccc2C#N)ncnc1O[C@H]1C[C@H]2CC[C@@H](C1)N2S(=O)(=O)C1CC1 CHEMBL3084386 EC50 86.0 nM
CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3c(c2)CCC3=O)CC1 CHEMBL2058398 EC50 86.0 nM
CC(=O)NC(C)(Cc1ccccc1)c1ccnc2c(-c3ccc(C(F)(F)F)cc3)cnn12 CHEMBL3260537 EC50 86.0 nM
CS(=O)(=O)N1CC=C(c2cc3cc(C4CCN(c5ccc(C(F)(F)F)cn5)CC4)oc3cn2)CC1 CHEMBL3715651 EC50 86.0 nM
CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3ccc(CC#N)cc3)cc2)C2CC2)CC1 CHEMBL3963955 EC50 86.0 nM
CC(O[C@H]1CC[C@]2(CCCCO2)CC1)c1nc(-c2ccc(CS(C)(=O)=O)c(F)c2)no1 CHEMBL4454946 EC50 86.0 nM
CC(C)OC(=O)N1CCC(Oc2ccnc(N3CCc4cc(S(C)(=O)=O)ccc43)c2)CC1 CHEMBL3113839 EC50 87.0 nM
CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3c(c2)C(=O)CO3)CC1 CHEMBL2058404 EC50 88.0 nM
Cc1ncccc1Oc1ncnc(N2C3CC4CC2CC(C3)N4C(=O)OCC(C)C)c1C CHEMBL2312525 EC50 88.0 nM
CCC[C@H]1C(=O)NN=C(c2ccc3nc(-c4cc(C)cs4)oc3c2)[C@@H]1C CHEMBL4114273 EC50 88.0 nM
CC[C@H]1C(c2ccc3nc(-c4ccc(OC(C)C)cc4)oc3c2)=NNC(=O)[C@@H]1C CHEMBL4111982 EC50 88.0 nM
O=C(Oc1ccccc1)N1CCC(N(C(=O)c2ccc(-c3cnco3)cc2)C2CC2)CC1 CHEMBL3978636 EC50 88.0 nM
CN(C)C(=O)c1ccc(OCCCCCC2CCC3(CC2)OCCO3)cc1 CHEMBL4215188 EC50 88.0 nM
Cc1c(Oc2ccc(/C=C3\SC(=O)NC3=O)cc2)ncnc1OC1CCN(C(=O)OC(C)(C)C)CC1 CHEMBL4741006 EC50 88.0 nM
CCc1csc(-c2cc(Cl)nc(Oc3cccc(NS(=O)(=O)c4ccc(Cl)cc4)c3)c2)n1 CHEMBL2391598 EC50 89.0 nM
O=C(Oc1ccc(F)cc1)N1CCC(N(C(=O)c2ccc(-c3cnco3)cc2)C2CC2)CC1 CHEMBL3932134 EC50 89.0 nM
CC(O[C@H]1CC[C@]2(CC1)COC(C)(C)C2)c1nc(-c2ccc(S(C)(=O)=O)c(F)c2)no1 CHEMBL4467856 EC50 89.0 nM
CC(C)c1noc(N2CCC(Oc3cc(N4CCc5cc(N6CCC(O)CC6=O)ccc54)ncn3)CC2)n1 CHEMBL4780236 EC50 89.0 nM
CC(C)OC(=O)N1CCC(COc2ccc(N3CCN(S(=O)(=O)CC4CCCCC4)CC3)nc2)CC1 CHEMBL1089857 EC50 90.0 nM
O=S(=O)(c1ccc(F)c(F)c1)N1CCCc2ccc(Oc3cc(-c4nc(C5CC5)no4)cc(Cl)n3)cc21 CHEMBL3113017 EC50 90.0 nM
COc1ccc(S(=O)(=O)N2CCCc3ccc(Oc4cc(-c5nc(C6CC6)no5)cc(Cl)n4)cc32)cc1 CHEMBL3113013 EC50 90.0 nM
O=S(=O)(c1ccc(F)cc1)N1CCCc2ccc(Oc3cc(-c4nc(C5CC5)no4)cc(Cl)n3)cc21 CHEMBL3113012 EC50 90.0 nM
CC(C)c1noc(N2CCC(Oc3cc(N4CCc5cc(N6CC(O)CCC6=O)ccc54)ncn3)CC2)n1 CHEMBL4754973 EC50 90.0 nM
O=S(=O)(Nc1cccc(Oc2cc(-c3ncco3)cc(Cl)n2)c1)c1ccc(Cl)cc1 CHEMBL2391596 EC50 91.0 nM
C[C@@H]1CN(c2nc(C(F)(F)F)no2)CCN1c1ncc(OCc2ccc(CS(C)(=N)=O)cc2F)cn1 CHEMBL3358008 EC50 91.0 nM
Cc1ncccc1Nc1ncnc(OC2CCN(C(=O)OC(C)C)CC2)c1C CHEMBL1951015 EC50 92.0 nM
CC(C)OC(=O)N1CCC(n2ncc3cc(-c4cc(F)c(C(=O)NCCO)cc4F)ncc32)CC1 CHEMBL3823972 EC50 92.0 nM
CCC[C@@H]1C(=O)NN=C(c2ccc3nc(-c4ccc(OC)cc4)oc3c2)[C@H]1C CHEMBL3891099 EC50 92.0 nM
CON(C)C(=O)c1ccc(-c2ccc(OCC3CCN(C(=O)OC(C)C)CC3)cn2)cc1F CHEMBL4070332 EC50 92.0 nM
Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)OC(C)(C)C#N)CC2)c1F CHEMBL3325847 EC50 92.9 nM
CC(C)(C)OC(=O)N1CCC2(CC1)CC(C(=O)Nc1cc(F)c(C#N)cc1F)=NO2 CHEMBL2177150 EC50 93.0 nM
Cc1c(Oc2ccc(-n3cnnn3)cc2)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)C CHEMBL2312515 Ki 94.0 nM
COc1ccc(-c2nc3ccc(C4=NNC(=O)CC4C)cc3o2)cc1 CHEMBL3942032 EC50 94.0 nM
CCCc1cnc(N2CCC(Oc3ccn(-c4ccc(-n5ccnc5)cc4)c(=O)c3)CC2)nc1 CHEMBL3338180 EC50 95.0 nM
CN(C)C(=O)c1ccc(OCCCCC[C@H]2CC[C@]3(CCCO3)CC2)cc1 CHEMBL4202826 EC50 95.0 nM
Cc1nc(-c2ccccc2)cn1-c1ccc(C(=O)N(C2CC2)C2CCN(C(=O)OC(C)(C)C)CC2)cc1 CHEMBL3956696 EC50 96.0 nM
CC(C)OC(=O)N1CCC(n2ncc3cc(-c4ccc(C(N)=O)cc4F)ncc32)CC1 CHEMBL3822567 EC50 97.0 nM
CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(OCCN4CCC(C#N)CC4)cc3)oc2c1 CHEMBL3947531 EC50 97.0 nM
COc1c(Nc2ccc(S(C)(=O)=O)cc2F)ncnc1OC1C[C@@H]2COC[C@@H](C1)N2C(=O)OC1(C)CC1 CHEMBL4172551 EC50 97.0 nM
CS(=O)(=O)c1ccc(N2CCC(C3CCN(c4ncccn4)CC3)CC2)cc1 CHEMBL1771085 EC50 98.0 nM
CON(C)C(=O)c1ccc(-c2csc3c(N(C)C4CCN(C(=O)OC(C)(C)C)CC4)ncnc23)cc1 CHEMBL4067537 EC50 98.0 nM
CC(C)(C)OC(=O)N1CCC2(CCc3cc(-c4ccc(CS(=O)(=O)Cc5ccncc5)cc4)ccc3O2)CC1 CHEMBL4279705 EC50 98.0 nM
CC(C)c1c(Nc2ccc(S(C)(=O)=O)cc2F)ncnc1O[C@H]1CC[C@]2(CC1)COC(C)(C)C2 CHEMBL4442128 EC50 98.0 nM
CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3ccno3)cc2)C2CC2)CC1 CHEMBL3894142 EC50 99.0 nM