CO[C@H](C)C(=O)N1CCc2nc(NCC(F)F)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2C1 CHEMBL4112875 IC50 0.0066 nM
CO[C@@H](C)C(=O)N1CCc2nc(NCC(F)F)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2C1 CHEMBL3912899 IC50 0.0083 nM
CC(=O)N1CCc2nc(NC(C)C)c(N3CCC(C(F)c4ccc(F)cc4F)CC3)nc2C1 CHEMBL3945884 IC50 0.0085 nM
CC(C)Nc1nc2c(nc1N1CCC(C(=O)c3cc(Cl)ccc3F)CC1)CN(C)CC2 CHEMBL3956687 IC50 0.0088 nM
CN(C)C(=O)N1CCc2nc(NCC(F)F)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2C1 CHEMBL3945220 IC50 0.0091 nM
CN1CCc2nc(NC3CC3)c(N3CCC(C(F)c4ccc(F)cc4F)CC3)nc2C1 CHEMBL3969026 IC50 0.0094 nM
CC(=O)N1CCc2nc(NC(C)C)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2C1 CHEMBL3938087 IC50 0.0095 nM
CC(=O)N1CCc2nc(NC(C)C)c(N3CCC(C(=O)c4cc(Cl)ccc4F)CC3)nc2C1 CHEMBL3920225 IC50 0.0098 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CCN(C(=O)N(C)C)C2 CHEMBL3909497 IC50 0.0104 nM
CC1Cc2nc(NCC(F)F)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2CN1S(C)(=O)=O CHEMBL3892898 IC50 0.0104 nM
CC(C)Nc1nc2c(nc1N1CCC([C@H](F)c3ccc(F)cc3F)CC1)CCN(C=O)C2 CHEMBL3890613 IC50 0.0114 nM
CC(=O)N1CCc2nc(NCC(F)F)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2C1 CHEMBL3931736 IC50 0.0115 nM
COc1ccc(OC2CCN(c3nc4c(nc3NC3CCC3)CCN(C(C)=O)C4)CC2)c(F)c1 CHEMBL3905204 IC50 0.012 nM
CC(=O)N1CCc2nc(N3CCC(C(F)c4ccc(F)cc4F)CC3)c(NC(C)C)nc2C1 CHEMBL3962092 IC50 0.0134 nM
CC(C)Nc1nc2c(nc1N1CCC(C(=O)c3cc(Cl)ccc3F)CC1)CCN(C)C2 CHEMBL3982858 IC50 0.0137 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CN(C(=O)N(C)C)CC2C CHEMBL3971468 IC50 0.0138 nM
CC(=O)N1CCc2nc(N3CCC(C(=O)c4cc(Cl)ccc4F)CC3)c(NC(C)C)nc2C1 CHEMBL3955078 IC50 0.0138 nM
COc1ccc(OC2CCN(c3nc4c(nc3NC3CCC3)CCN(C(=O)N(C)C)C4)CC2)c(F)c1 CHEMBL3915516 IC50 0.0138 nM
COCCNC(=O)N1CCc2nc(NC(C)C)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2C1 CHEMBL3957710 IC50 0.0149 nM
CN1CCc2nc(NC3CC3)c(N3CCC([C@H](F)c4ccc(F)cc4F)CC3)nc2C1 CHEMBL3935897 IC50 0.0152 nM
COc1ccc(OC2CCN(c3nc4c(nc3NC(C)C)CCN(C(=O)N(C)C)C4)CC2)c(F)c1 CHEMBL3976386 IC50 0.0166 nM
COC(C)C(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NC(C)C)nc2C1 CHEMBL3943282 IC50 0.0168 nM
CC(C)Nc1nc2c(nc1N1CCC(C(F)c3ccc(F)cc3F)CC1)CN(C)CC2 CHEMBL3930473 IC50 0.0171 nM
COCC(=O)N1CCc2nc(NC(C)C)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2C1 CHEMBL3967591 IC50 0.0173 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CCN(C(=O)C1CCCO1)C2 CHEMBL3908467 IC50 0.0179 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CN(C(=O)CC#N)CC2 CHEMBL3963072 IC50 0.018 nM
CO[C@H](C)C(=O)N1Cc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NCC(F)F)nc2CC1C CHEMBL4113017 IC50 0.0185 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CN(C(=O)C1CCCO1)CC2 CHEMBL3986433 IC50 0.0195 nM
CC(C)Nc1nc2c(nc1N1CCC(C(F)c3ccc(F)cc3F)CC1)CCN(C(=O)N(C)C)C2 CHEMBL3925720 IC50 0.0197 nM
COc1ccc(OC2CCN(c3nc4c(nc3NC3CCC3)CN(C(C)=O)CC4)CC2)c(F)c1 CHEMBL3943478 IC50 0.0199 nM
CO[C@@H](C)C(=O)N1Cc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NCC(F)F)nc2CC1C CHEMBL3949818 IC50 0.0209 nM
CC1Cc2nc(NCC(F)F)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2CN1C(=O)C(F)F CHEMBL3905140 IC50 0.0221 nM
COCC(=O)N1Cc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NCC(F)F)nc2CC1C CHEMBL3923125 IC50 0.023 nM
CC1Cc2nc(NCC(F)F)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2CN1C CHEMBL3985327 IC50 0.0232 nM
CC(C)Nc1nc2c(nc1N1CCC([C@@H](F)c3ccc(F)cc3F)CC1)CCN(C=O)C2 CHEMBL4113420 IC50 0.0236 nM
CC(C)Nc1nc2c(nc1N1CCC(C(F)c3ccc(F)cc3F)CC1)CN(C(=O)N(C)C)CC2 CHEMBL3921525 IC50 0.0237 nM
CC1Cc2nc(NCC(F)F)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2CN1C(=O)C1CC1 CHEMBL3967336 IC50 0.0239 nM
CC(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NC(C)C)nc2C1 CHEMBL3973483 IC50 0.0246 nM
CC(C)Nc1nc2c(nc1N1CCC(C(=O)c3cc(Cl)ccc3F)CC1)CN(C(=O)N(C)C)CC2 CHEMBL3948026 IC50 0.0249 nM
CC(=O)N1Cc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NCC(F)F)nc2CC1C CHEMBL3945233 IC50 0.0249 nM
CN1CCc2nc(NC3CC3)c(N3CCC([C@@H](F)c4ccc(F)cc4F)CC3)nc2C1 CHEMBL4111582 IC50 0.0265 nM
COc1ccc(OC2CCN(c3nc4c(nc3NC(C)C)CCN(C)C4)CC2)c(F)c1 CHEMBL3911615 IC50 0.0266 nM
CN(C)C(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NCC(F)F)nc2C1 CHEMBL3924362 IC50 0.0269 nM
CC(=O)N1CCc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(NC(C)C)nc2C1 CHEMBL3937342 IC50 0.027 nM
CC(=O)N1CCc2nc(N3CCC([C@H](F)c4ccc(F)cc4F)CC3)c(NC(C)C)nc2C1 CHEMBL3965180 IC50 0.0274 nM
CCC(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NC(C)C)nc2C1 CHEMBL3965158 IC50 0.0276 nM
CC(C)Nc1nc2c(nc1N1CCN(Cc3ccc(F)cc3F)CC1)CCN(S(C)(=O)=O)C2 CHEMBL3946230 IC50 0.0279 nM
CC(C)Nc1nc2c(nc1N1CCN(Cc3ccc(F)cc3F)CC1)CCN(C(=O)C(C)C)C2 CHEMBL3892902 IC50 0.029 nM
COCCNC(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NC(C)C)nc2C1 CHEMBL3945303 IC50 0.0298 nM
CC(C)Nc1nc2c(nc1N1CCC(C(F)c3ccc(F)cc3F)CC1)CCN(C)C2 CHEMBL3934607 IC50 0.0303 nM
CCC(=O)N1CCc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(NC(C)C)nc2C1 CHEMBL3975542 IC50 0.0309 nM
CC1Cc2nc(NCC(F)F)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2CN1C(=O)N(C)C CHEMBL3975976 IC50 0.0314 nM
COc1ccc(OC2CCN(c3nc4c(nc3NC3CCC3)CN(C(=O)N(C)C)CC4)CC2)c(F)c1 CHEMBL3951645 IC50 0.0325 nM
CC(C)Nc1nc2c(nc1N1CCC(C(=O)c3cc(Cl)ccc3F)CC1)CCN(C(=O)N(C)C)C2 CHEMBL3927473 IC50 0.0327 nM
COc1ccc(OC2CCN(c3nc4c(nc3NC(C)C)CN(C(=O)N(C)C)CC4)CC2)c(F)c1 CHEMBL3935030 IC50 0.035 nM
CC(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NC3CC(F)(F)C3)nc2C1 CHEMBL3954223 IC50 0.0359 nM
CC(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)[C@H](F)C3)c(NC(C)C)nc2C1 CHEMBL4107203 IC50 0.0378 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CCN(C(=O)c1ccno1)C2 CHEMBL3902681 IC50 0.0387 nM
CCC(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(N[C@H]3CCOC3)nc2C1 CHEMBL3979765 IC50 0.0392 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CN(C=O)CC2 CHEMBL3899720 IC50 0.0432 nM
CC(=O)N1CCc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(NC3CCC3)nc2C1 CHEMBL3970413 IC50 0.0437 nM
CS(=O)(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NC3CCC3)nc2C1 CHEMBL3972078 IC50 0.0493 nM
CC(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NCC(F)F)nc2C1 CHEMBL3954423 IC50 0.0497 nM
CC1c2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NCC(F)F)nc2CCN1S(C)(=O)=O CHEMBL3909048 IC50 0.052 nM
CC(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NC3CCC3)nc2C1 CHEMBL3961603 IC50 0.055 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CCN(C(=O)CC#N)C2 CHEMBL3939970 IC50 0.0552 nM
CS(=O)(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NCC(F)F)nc2C1 CHEMBL3987027 IC50 0.0572 nM
CC(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(N[C@H]3CCOC3)nc2C1 CHEMBL3962956 IC50 0.0587 nM
CCC(=O)N1CCc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(N[C@H]3CCOC3)nc2C1 CHEMBL3944212 IC50 0.0591 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CCN(S(C)(=O)=O)C2C CHEMBL3965246 IC50 0.0593 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CN(C)CC2 CHEMBL3913587 IC50 0.0595 nM
CC(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(N[C@H]3C[C@@H](O)C3)nc2C1 CHEMBL3908448 IC50 0.0615 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CCN(S(C)(=O)=O)C2 CHEMBL3917421 IC50 0.0618 nM
CC[C@H](C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CCN(C(C)=O)C2 CHEMBL3890744 IC50 0.062 nM
COc1ccc(OC2CCN(c3nc4c(nc3NC(C)C)CCN(C(C)=O)C4)CC2)c(F)c1 CHEMBL3964924 IC50 0.0625 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CCN(CN1CCOCC1)C2 CHEMBL3912262 IC50 0.0626 nM
CC(=O)N1CCc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(N[C@@H]3CCOC3)nc2C1 CHEMBL4109901 IC50 0.0632 nM
CO[C@H](C)C(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NCC(F)F)nc2C1 CHEMBL4113797 IC50 0.064 nM
COCC(=O)N1CCc2nc(NCC(F)F)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2C1C CHEMBL3980074 IC50 0.068 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CN(CCF)CC2 CHEMBL3982275 IC50 0.0692 nM
COCC(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NC(C)C)nc2C1 CHEMBL3954037 IC50 0.0715 nM
CC(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NC(C)C)nc2C1C CHEMBL3903382 IC50 0.0732 nM
COc1ccc(OC2CCN(c3nc4c(nc3NC(C)C)CN(C(C)=O)CC4)CC2)c(F)c1 CHEMBL3965555 IC50 0.0741 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CCN(CCF)C2 CHEMBL3959353 IC50 0.0748 nM
CC(=O)N1CCc2nc(NCC(F)F)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2C1C CHEMBL3961475 IC50 0.076 nM
CC(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(N[C@H]3C[C@H](O)C3)nc2C1 CHEMBL3894008 IC50 0.078 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CCN(C(=O)[C@@H]1CCCN1C)C2 CHEMBL3966731 IC50 0.0781 nM
O=C(C(F)F)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NCC(F)F)nc2C1 CHEMBL3923277 IC50 0.0788 nM
COCC(=O)N1CCc2nc(NCC(F)F)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2C1 CHEMBL3940900 IC50 0.0795 nM
CC1c2nc(NCC(F)F)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2CCN1C(=O)C1CC1 CHEMBL3965124 IC50 0.085 nM
CC(=O)N1CCc2nc(N3CCC(Oc4ccc(C#N)cc4F)CC3)c(NC(C)C)nc2C1 CHEMBL3902976 IC50 0.0866 nM
CC1c2nc(NCC(F)F)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2CCN1S(C)(=O)=O CHEMBL3980789 IC50 0.087 nM
CC(=O)N1CCc2nc(NC(C)C)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2C1C CHEMBL3940326 IC50 0.088 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CCN(C)C2 CHEMBL3941883 IC50 0.0901 nM
COCC(=O)N1CCc2nc(NC(C)C)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2C1C CHEMBL3927786 IC50 0.091 nM
CC1c2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NCC(F)F)nc2CCN1C(=O)N(C)C CHEMBL3934813 IC50 0.0935 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CCN(C(=O)C(F)F)C2C CHEMBL3931355 IC50 0.095 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CN(S(C)(=O)=O)CC2 CHEMBL3927098 IC50 0.0956 nM
CC(=O)N1CCc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(N[C@H]3CCOC3)nc2C1 CHEMBL3916279 IC50 0.0978 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)C(C)N(S(C)(=O)=O)CC2 CHEMBL3950785 IC50 0.098 nM
CC(=O)N1CCc2nc(NC(C)C)c(N3CCC(Oc4ccc(C#N)cc4F)CC3)nc2C1 CHEMBL3985718 IC50 0.105 nM
CC(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(N[C@@H](C)CCO)nc2C1 CHEMBL3913321 IC50 0.1071 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CCN(C(=O)N(C)C)C2C CHEMBL3940392 IC50 0.1096 nM
O=C(C(F)F)N1CCc2nc(NCC(F)F)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2C1 CHEMBL3929061 IC50 0.1106 nM
CO[C@@H](C)C(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NCC(F)F)nc2C1 CHEMBL3930895 IC50 0.111 nM
CC(=O)O[C@H]1C[C@@H](Nc2nc3c(nc2N2CCC(Oc4ccc(F)cc4F)CC2)CCN(C(C)=O)C3)C1 CHEMBL3917400 IC50 0.1135 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)C(C)N(C(=O)C(F)F)CC2 CHEMBL3957130 IC50 0.1155 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(C#N)cc3F)CC1)CN(C(=O)C1CC1)CC2 CHEMBL3950698 IC50 0.122 nM
CC(=O)N1CCc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(N[C@H]3C[C@@H](O)C3)nc2C1 CHEMBL3924124 IC50 0.122 nM
CC1c2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NCC(F)F)nc2CCN1C(=O)C1CC1 CHEMBL3911121 IC50 0.126 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CCN(C(=O)C(F)F)C2 CHEMBL3919622 IC50 0.1292 nM
COC(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NC(C)C)nc2C1 CHEMBL3931864 IC50 0.1295 nM
COC(=O)N1CCc2nc(NC(C)C)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2C1 CHEMBL3966672 IC50 0.1317 nM
COc1ccc(OC2CCN(c3nc4c(nc3NC(C)C)CN(C)CC4)CC2)c(F)c1 CHEMBL3902181 IC50 0.1402 nM
COc1ccc(OC2CCN(c3nc4c(nc3NC3CC3)CCN(C)C4)CC2)c(F)c1 CHEMBL3944841 IC50 0.145 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CCN(S(=O)(=O)C(C)C)C2 CHEMBL3946202 IC50 0.149 nM
CS(=O)(=O)N1CCc2nc(NCC(F)F)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2C1 CHEMBL3901094 IC50 0.163 nM
CC(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NCC(F)F)nc2C1C CHEMBL3940225 IC50 0.178 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)C(C)N(C(=O)N(C)C)CC2 CHEMBL3917829 IC50 0.1794 nM
CC(=O)N1CCc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(N[C@H]3C[C@H](F)C3)nc2C1 CHEMBL3978840 IC50 0.1859 nM
CC(=O)N1CCc2nc(NC(C)C)c(N3CCC(S(=O)(=O)c4ccc(F)cc4)CC3)nc2C1 CHEMBL3927734 IC50 0.1877 nM
CC1c2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NCC(F)F)nc2CCN1C(=O)C(F)F CHEMBL3952280 IC50 0.1933 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CN(CC(F)F)CC2 CHEMBL3896084 IC50 0.1997 nM
COc1ccc(S(=O)(=O)C2CCN(c3nc4c(nc3NC(C)C)CCN(C(C)=O)C4)CC2)c(F)c1 CHEMBL3908642 IC50 0.2002 nM
COCC(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NCC(F)F)nc2C1C CHEMBL3946805 IC50 0.208 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CN(C(=O)C1CC1)CC2 CHEMBL3894029 IC50 0.2106 nM
CC1c2nc(NCC(F)F)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2CCN1C(=O)C(F)F CHEMBL3977786 IC50 0.2122 nM
CC(=O)O[C@H]1C[C@@H](Nc2nc3c(nc2N2CCN(Cc4ccc(F)cc4F)CC2)CCN(C(C)=O)C3)C1 CHEMBL3983522 IC50 0.2198 nM
CC(=O)N1CCc2nc(NC(C)C)c(N3CCC(S(=O)(=O)c4ccccc4F)CC3)nc2C1 CHEMBL3912855 IC50 0.247 nM
CC(=O)N1CCc2nc(NC(C)C)c(N3CCC(S(=O)(=O)c4cccc(F)c4)CC3)nc2C1 CHEMBL3979906 IC50 0.2498 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)C(C)N(C(=O)C1CC1)CC2 CHEMBL3942541 IC50 0.259 nM
CC[C@@H](C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CCN(C(C)=O)C2 CHEMBL4108798 IC50 0.3193 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CCN(C(=O)C1CC1)C2 CHEMBL3936862 IC50 0.3402 nM
COc1cccc(S(=O)(=O)C2CCN(c3nc4c(nc3NC(C)C)CCN(C(C)=O)C4)CC2)c1 CHEMBL3986113 IC50 0.3415 nM
CC(=O)N1CCc2nc(N3CCN(Cc4ccc(C#N)cc4F)CC3)c(NC(C)C)nc2C1 CHEMBL3902954 IC50 0.3629 nM
CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CCN(C(=O)N1CCCC1)C2 CHEMBL3892470 IC50 0.391 nM
CC(=O)O[C@H]1C[C@H](Nc2nc3c(nc2N2CCC(Oc4ccc(F)cc4F)CC2)CCN(C(C)=O)C3)C1 CHEMBL3970568 IC50 0.6039 nM
Cc1nccc2nc(NC3CC3)c(N3CCC(Cc4ccc(F)cc4F)CC3)nc12 CHEMBL3716698 IC50 2.0 nM
CC(C)Nc1nc2cnncc2nc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL3716409 IC50 4.0 nM
CN(C)C(=O)c1cc2nc(NC3CC3)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2cn1 CHEMBL3716065 IC50 5.0 nM
CC(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(N[C@@H]3CCOC3)nc2C1 CHEMBL4778540 Ki 5.5 nM
O=C(c1nccc2nc(NC3CC3)c(N3CCC([C@H](F)c4ccc(F)cc4F)CC3)nc12)N1CCOCC1 CHEMBL3715455 IC50 6.0 nM
COc1ccc(OC2CCN(c3nc4cnncc4nc3NC(C)C)CC2)c(F)c1 CHEMBL3719293 IC50 6.0 nM
CC(C)Nc1nc2cnncc2nc1N1CCC(C(F)c2ccc(F)cc2F)CC1 CHEMBL3719381 IC50 6.0 nM
Cc1cc2nc(NC3CC3)c(N3CCC([C@@H](F)c4ccc(F)cc4F)CC3)nc2cn1 CHEMBL3717215 IC50 6.0 nM
CC(C)Nc1nc2cc(C(=O)N(C)C)ncc2nc1N1CCC(Oc2ccc(Cl)cc2F)CC1 CHEMBL3718034 IC50 6.0 nM
O=C(c1nccc2nc(NC3CC3)c(N3CCC([C@@H](F)c4ccc(F)cc4F)CC3)nc12)N1CCOCC1 CHEMBL3717662 IC50 7.0 nM
Cc1cc2nc(NC3CC3)c(N3CCC(C(F)c4ccc(F)cc4F)CC3)nc2cn1 CHEMBL3716497 IC50 7.0 nM
CC(C)Nc1nc2cnncc2nc1N1CCC(Oc2ccc(Cl)cc2F)CC1 CHEMBL3718978 IC50 7.0 nM
Fc1ccc(CN2CCN(c3nc4cnccc4nc3NC3CC3)CC2)c(F)c1 CHEMBL4598390 Ki 7.0 nM
CN(C)C(=O)c1cc2nc(NC3CC3)c(N3CCC([C@@H](F)c4ccc(F)cc4F)CC3)nc2cn1 CHEMBL3715399 IC50 8.0 nM
CC(C)Nc1nc2cnncc2nc1N1CCC(Oc2ccc(OCF)cc2F)CC1 CHEMBL3718447 IC50 8.0 nM
Cc1nccc2nc(NC3CC3)c(N3CCC(C(F)c4ccc(F)cc4F)CC3)nc12 CHEMBL3716923 IC50 9.0 nM
CN(C)C(=O)c1cc2nc(NC3CC3)c(N3CCC([C@H](F)c4ccc(F)cc4F)CC3)nc2cn1 CHEMBL3717210 IC50 10.0 nM
Cc1cc2nc(NC3CC3)c(N3CCC([C@H](F)c4cc(F)ccc4F)CC3)nc2cn1 CHEMBL3716076 IC50 11.0 nM
N#Cc1cc2nc(NC3CC3)c(N3CCC([C@H](F)c4ccc(F)cc4F)CC3)nc2cn1 CHEMBL3718241 IC50 11.0 nM
COc1ccc(OC2CCN(c3nc4ccncc4nc3NC(C)C)CC2)c(F)c1 CHEMBL3716496 IC50 12.0 nM
CC(C)Oc1cc(Cl)ccc1CNc1cc(-c2ccccc2OCCCCCCNC(=O)c2ccc(-c3c4ccc(N(C)C)cc4[o+]c4cc(N(C)C)ccc34)c(C(=O)[O-])c2)nc2ncnn12 CHEMBL5410506 pKi 13.18 nM
CC(C)Nc1nc2cnncc2nc1N1CCC([C@@H](F)c2ccc(F)cc2F)CC1 CHEMBL3718141 IC50 14.0 nM
Fc1ccc(OC2CCN(c3nc4ccncc4nc3NC3CCC3)CC2)c(F)c1 CHEMBL3719010 IC50 14.0 nM
CSc1ccc(OC2CCN(c3nc4cnncc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3714886 IC50 14.0 nM
N#Cc1cc2nc(NC3CC3)c(N3CCC(Cc4ccc(F)cc4F)CC3)nc2cn1 CHEMBL3718016 IC50 15.0 nM
COc1ccc(CC2CCN(c3nc4cnncc4nc3NC(C)C)CC2)c(F)c1 CHEMBL3718107 IC50 15.0 nM
Fc1ccc([C@H](F)C2CCN(c3nc4cnc(Cl)cc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3719239 IC50 15.0 nM
Fc1ccc(C(F)(F)C2CCN(c3nc4cnccc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3718567 IC50 16.0 nM
CC(C)Nc1nc2cc(C(=O)N(C)C)ncc2nc1N1CCC(C(=O)c2cc(F)cc(F)c2)CC1 CHEMBL3717950 IC50 16.0 nM
CC(=O)N1C=Cc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NC(C)C)nc2C1 CHEMBL5093828 Ki 16.0 nM
Cc1cc2nc(N[C@H]3CCOC3)c(N3CCN(Cc4ccc(F)cc4F)CC3)nc2cn1 CHEMBL4755280 EC50 16.5 nM
N#Cc1cc2nc(NC3CC3)c(N3CCC([C@@H](F)c4ccc(F)cc4F)CC3)nc2cn1 CHEMBL3717730 IC50 17.0 nM
N#Cc1cc2nc(NC3CC3)c(N3CCC([C@@H](F)c4ccc(F)cc4F)CC3)nc2cn1 CHEMBL3719402 IC50 17.0 nM
Fc1ccc(OC2CCN(c3nc4cnncc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3718314 IC50 18.0 nM
Cc1nccc2nc(NC3CC3)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc12 CHEMBL3715878 IC50 18.0 nM
COc1ccc(OC2CCN(c3nc4cnc(C)cc4nc3NC3CC3)CC2)c(F)c1 CHEMBL4776419 EC50 18.5 nM
Fc1ccc(CC2CCN(c3nc4ccccc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3716101 IC50 19.0 nM
Fc1ccc(CC2CCN(c3nc4cnccc4nc3NC3CC3)CC2)c(F)c1 CHEMBL4554913 IC50 19.0 nM
COc1ccc(OC2CCN(c3nc4cnncc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3717381 IC50 20.0 nM
Cc1cc2nc(NC3CC3)c(N3CCC(Cc4ccc(F)cc4F)CC3)nc2cn1 CHEMBL3716681 IC50 20.0 nM
Fc1ccc(F)c(C(F)C2CCN(c3nc4cnccc4nc3NC3CC3)CC2)c1 CHEMBL3718147 IC50 20.0 nM
CC(C)Nc1nc2cnccc2nc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL3718119 IC50 20.0 nM
CC(C)Nc1nc2cnccc2nc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL3715254 IC50 21.0 nM
CC[C@H](C)Nc1nc2cnncc2nc1N1CCC(Oc2ccc(OC)cc2F)CC1 CHEMBL3719318 IC50 21.0 nM
COc1ccc(C(=O)C2CCN(c3nc4cnccc4nc3NC3CC3)CC2)c(F)c1 CHEMBL4545689 IC50 21.0 nM
Fc1ccc(CN2CCN(c3nc4cnccc4nc3NC3CC3)CC2)c(F)c1 CHEMBL4474256 IC50 21.0 nM
Cc1cc2nc(NC3COC3)c(N3CCN(Cc4ccc(F)cc4F)CC3)nc2cn1 CHEMBL4744148 EC50 21.9 nM
O=C(c1cc2nc(NC3CC3)c(N3CCC([C@@H](F)c4ccc(F)cc4F)CC3)nc2cn1)N1CCC1 CHEMBL3716246 IC50 22.0 nM
Fc1ccc([C@H](F)C2CCN(c3nc4cnncc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3716656 IC50 22.0 nM
O=C(c1cc2nc(NC3CC3)c(N3CCC([C@@H](F)c4ccc(F)cc4F)CC3)nc2cn1)N1CCC1 CHEMBL3719408 IC50 22.0 nM
O=C(c1cc2nc(NC3CC3)c(N3CCC([C@H](F)c4ccc(F)cc4F)CC3)nc2cn1)N1CCC1 CHEMBL3717693 IC50 23.0 nM
O=C(c1cc2nc(NC3CC3)c(N3CCC([C@H](F)c4ccc(F)cc4F)CC3)nc2cn1)N1CCC1 CHEMBL3719518 IC50 23.0 nM
N#Cc1cc2nc(N3CCC([C@@H](F)c4ccc(F)cc4F)CC3)c(NC3CC3)nc2cn1 CHEMBL3716020 IC50 24.0 nM
N#Cc1ccc2nc(NC3CC3)c(N3CCC(C(F)c4ccc(F)cc4F)CC3)nc2c1 CHEMBL3719236 IC50 24.0 nM
Fc1ccc([C@@H](F)C2CCN(c3nc4cnccc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3717872 IC50 24.0 nM
COc1ccc(CC2CCN(c3nc4cnc(C#N)cc4nc3NC(C)C)CC2)c(F)c1 CHEMBL3716056 IC50 26.0 nM
O=C(c1cc2nc(NC3CC3)c(N3CCC([C@@H](F)c4ccc(F)cc4F)CC3)nc2cn1)N1CCC1F CHEMBL3716960 IC50 26.0 nM
Fc1ccc([C@@H](F)C2CCN(c3nc4cnncc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3719076 IC50 26.0 nM
Fc1ccc(CC2CCN(c3nc4ccncc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3719347 IC50 27.0 nM
CC(C)Nc1nc2cc(C#N)ncc2nc1N1CCC(C(=O)c2cc(F)cc(F)c2)CC1 CHEMBL3717745 IC50 28.0 nM
Fc1ccc(Cl)cc1CN1CCN(c2nc3cnccc3nc2NC2CC2)CC1 CHEMBL3715393 IC50 29.0 nM
Fc1ccc(C(F)C2CCN(c3nc4cnc(Br)cc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3718399 IC50 29.0 nM
CC(C)Nc1nc2cnccc2nc1N1CCC(C(F)c2ccc(F)cc2F)CC1 CHEMBL3716757 IC50 29.0 nM
COc1cc2nc(NC3CC3)c(N3CCC(Cc4ccc(F)cc4F)CC3)nc2cn1 CHEMBL3718570 IC50 29.0 nM
N#Cc1ccc2nc(N3CCC(C(F)c4ccc(F)cc4F)CC3)c(NC3CC3)nc2c1 CHEMBL3715914 IC50 29.0 nM
Fc1ccc([C@@H](F)C2CCN(c3nc4cnc(Cl)cc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3716097 IC50 29.0 nM
Fc1cc(Cl)ccc1OC1CCN(c2nc3cnncc3nc2NC2CC2)CC1 CHEMBL3715787 IC50 30.0 nM
CC[C@@H](C)Nc1nc2cnncc2nc1N1CCC(Oc2ccc(OC)cc2F)CC1 CHEMBL3718714 IC50 30.0 nM
COCCNc1nc2ccncc2nc1N1CCC(Cc2ccc(F)cc2F)CC1 CHEMBL3718235 IC50 30.0 nM
Cc1cc2nc(N[C@@H]3CCOC3)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2cn1 CHEMBL4798089 EC50 30.1 nM
Fc1ccc(CC2CCN(c3nc4cnc(Cl)cc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3716946 IC50 31.0 nM
Cc1nncc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NC(C)C)nc12 CHEMBL4437192 IC50 31.0 nM
Cn1cccc(C(=O)Nc2cc(S(C)(=O)=O)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)c1=O CHEMBL4548470 pEC50 31.62 nM
Clc1ccc(Cl)c(CN2CCN(c3nc4cnccc4nc3NC3CC3)CC2)c1 CHEMBL3715202 IC50 32.0 nM
O=C(c1cc(Cl)ccc1F)C1CCN(c2nc3cnccc3nc2NC2CC2)CC1 CHEMBL3718030 IC50 35.0 nM
COc1ccc(OC2CCN(c3nc4cnncc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3719439 IC50 36.0 nM
COc1ccc(CN2CCN(c3nc4cnc(C)cc4nc3NC(C)C)CC2)c(F)c1 CHEMBL4752730 EC50 37.3 nM
CCNc1nc2cnccc2nc1N1CCC(Oc2ccc(OC)cc2F)CC1 CHEMBL3715573 IC50 39.0 nM
COc1nc(C)ncc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4472869 pEC50 39.81 nM
COc1ncccc1C(=O)Nc1cc(C(=O)N(C)C)c(C#N)cc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4561989 pEC50 39.81 nM
CCn1ncc(C(=O)Nc2cc(C#N)cnc2N2CCC(Oc3ccc(F)cc3F)CC2)c1OC CHEMBL4580819 pEC50 39.81 nM
Cn1cccc(C(=O)Nc2cc(C#N)cnc2N2CCC(Oc3ccc(F)cc3F)CC2)c1=O CHEMBL4588217 pEC50 39.81 nM
Cc1cccc(C(=O)Nc2cc(C#N)cnc2N2CCC(Oc3ccc(F)cc3F)CC2)n1 CHEMBL4582708 pEC50 39.81 nM
COc1ccncc1C(=O)Nc1cc(C)cnc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4438666 pEC50 39.81 nM
N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cccc3c2OCC3)c1 CHEMBL4473134 pEC50 39.81 nM
COc1cc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cnccc2OC)cn1 CHEMBL4447161 pEC50 39.81 nM
COc1ccncc1C(=O)Nc1cc(S(C)(=O)=O)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4438448 pEC50 39.81 nM
COc1ncccc1C(=O)Nc1cc(S(C)(=O)=O)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4581699 pEC50 39.81 nM
Cc1cc2nc(NC(C)C)c(N3CCC(Oc4ccc(OC(F)F)cc4F)CC3)nc2cn1 CHEMBL4762968 EC50 39.9 nM
CC(C)Nc1nc2cc(C(=O)N(C)C)ncc2nc1N1CCN(Cc2ccc(F)cc2F)CC1 CHEMBL3716707 IC50 40.0 nM
COc1ccc(C(=O)C2CCN(c3nc4c(C#N)nccc4nc3NC3CC3)CC2)c(F)c1 CHEMBL4457599 IC50 43.0 nM
COc1ccc(OC2CCN(c3nc4ccncc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3714945 IC50 44.0 nM
COc1cccc(CN2CCN(c3nc4cnncc4nc3NC(C)C)CC2)c1 CHEMBL3717678 IC50 44.0 nM
N#Cc1cc2nc(N3CCC([C@H](F)c4ccc(F)cc4F)CC3)c(NC3CC3)nc2cn1 CHEMBL3718951 IC50 45.0 nM
Cc1nccc2nc(NC3CC3)c(N3CCC(C(F)(F)c4cc(F)ccc4F)CC3)nc12 CHEMBL3717583 IC50 45.0 nM
Fc1ccc(Cl)cc1C(F)(F)C1CCN(c2nc3cnccc3nc2NC2CC2)CC1 CHEMBL3716755 IC50 46.0 nM
Cc1cc2nc(N[C@@H]3CCOC3)c(N3CCN(Cc4ccc(F)cc4F)CC3)nc2cn1 CHEMBL4758785 EC50 47.9 nM
Cc1cc2nc(N[C@H]3C[C@H](O)C3)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2cn1 CHEMBL4795011 EC50 48.2 nM
CC(C)Nc1nc2ccc(C#N)cc2nc1N1CCC([C@@H](F)c2ccc(F)cc2F)CC1 CHEMBL3715703 IC50 49.0 nM
Cc1cc2nc(N[C@H]3C[C@H](F)C3)c(N3CCN(Cc4ccc(F)cc4F)CC3)nc2cn1 CHEMBL4758376 EC50 49.4 nM
Cc1cc2nc(N[C@H]3CCOC3)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2cn1 CHEMBL4743248 EC50 49.6 nM
Fc1cc(F)c(CN2CCN(c3nc4cnccc4nc3NC3CC3)CC2)cc1F CHEMBL3716683 IC50 50.0 nM
N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cccnc2OC(F)F)c1 CHEMBL4456504 pEC50 50.12 nM
COc1ncccc1C(=O)Nc1cc(C#N)c(C(=O)N(C)C)cc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4521996 pEC50 50.12 nM
COc1ccncc1C(=O)Nc1cc(C(=O)N(C)C)ncc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4440154 pEC50 50.12 nM
COc1ncc(F)cc1C(=O)Nc1ccc(C#N)nc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4582346 pEC50 50.12 nM
COc1cc(F)c(F)cc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4441926 pEC50 50.12 nM
COc1ncc(F)cc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4517012 pEC50 50.12 nM
COc1ccc(F)cc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4449474 pEC50 50.12 nM
COc1ccncc1C(=O)Nc1ccc(C#N)cc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4540531 pEC50 50.12 nM
COc1ncccc1C(=O)Nc1cc(C#N)cnc1N1CCN(Cc2ccc(F)cc2)CC1 CHEMBL4585412 pEC50 50.12 nM
N#Cc1cnc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2ccccn2)c1 CHEMBL4441615 pEC50 50.12 nM
COCc1cnc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cccnc2OC)c1 CHEMBL4470030 pEC50 50.12 nM
COc1ccncc1C(=O)Nc1ccc(C)nc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4451957 pEC50 50.12 nM
COc1nn(C)cc1C(=O)Nc1cc(C#N)cnc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4570767 pEC50 50.12 nM
Cc1cccnc1C(=O)Nc1cc(C#N)cnc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4515296 pEC50 50.12 nM
Cc1ccc(F)c(C(=O)Nc2cc(C#N)cnc2N2CCC(Oc3ccc(F)cc3F)CC2)n1 CHEMBL4551756 pEC50 50.12 nM
N#Cc1cnc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cc(Cl)ccn2)c1 CHEMBL4529737 pEC50 50.12 nM
COc1nc(C)ccc1C(=O)Nc1cc(C#N)c(F)cc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4439508 pEC50 50.12 nM
COc1ccc(OC2CCN(c3ccc(C#N)cc3NC(=O)c3cccn(C)c3=O)CC2)c(F)c1 CHEMBL4591254 pEC50 50.12 nM
COc1ccccc1C(=O)Nc1cc(S(C)(=O)=O)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4469715 pEC50 50.12 nM
CC(C)Nc1nc2ccccc2nc1N1CCC(Oc2ccc(Cl)cc2F)CC1 CHEMBL4467913 IC50 51.0 nM
Cc1cc2nc(N[C@H]3C[C@@H](O)C3)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2cn1 CHEMBL4744002 EC50 52.3 nM
Clc1ccc(Cl)c(CN2CCN(c3nc4cnccc4nc3NC3CC3)CC2)c1 CHEMBL3719486 EC50 53.0 nM
Oc1ccc(OC2CCN(c3nc4ccncc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3715941 IC50 54.0 nM
COc1ccc(C(=O)C2CCN(c3nc4cnncc4nc3NC(C)C)CC2)c(F)c1 CHEMBL3715744 IC50 54.0 nM
COc1ccc(OC2CCN(c3nc4c(C(=O)N(C)C)nccc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3717815 IC50 54.0 nM
CN1CCN(C(=O)c2cc3nc(NC4CC4)c(N4CCC(C(=O)c5cc(C#N)ccc5F)CC4)nc3cn2)CC1 CHEMBL4572651 IC50 54.0 nM
Clc1ccc(Cl)c(CN2CCN(c3nc4ccncc4nc3NC3CC3)CC2)c1 CHEMBL3719411 EC50 55.0 nM
Clc1ccc(Cl)c(CN2CCN(c3nc4ccncc4nc3NC3CC3)CC2)c1 CHEMBL3718052 IC50 56.0 nM
Cc1cc2nc(NC(C)C)c(N3CCN(Cc4ccc(F)cc4F)CC3)nc2cn1 CHEMBL4763822 EC50 59.4 nM
Cc1nnc(C)c2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NC(C)C)nc12 CHEMBL4439869 IC50 60.0 nM
Cc1cc2nc(N[C@H]3C[C@H](F)C3)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2cn1 CHEMBL4800661 EC50 61.4 nM
O=C(c1cc(F)ccc1Cl)C1CCN(c2nc3cnccc3nc2NC2CC2)CC1 CHEMBL3715955 IC50 62.0 nM
Clc1ccc(Cl)c(CN2CCN(c3nc4cncc(Cl)c4nc3NC3CC3)CC2)c1 CHEMBL3715595 IC50 62.0 nM
Fc1ccc(F)c(CN2CCN(c3nc4cncc(Cl)c4nc3NC3CC3)CC2)c1 CHEMBL4470460 IC50 62.0 nM
Cc1cc2nc(NC3CC3)c(N3CCC(Oc4ccc(OC(F)F)cc4F)CC3)nc2cn1 CHEMBL4760143 EC50 62.6 nM
COc1ncccc1C(=O)Nc1cc(C#N)ncc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4467554 pEC50 63.1 nM
CCCNC(=O)c1cc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cccnc2OC)cn1 CHEMBL4594079 pEC50 63.1 nM
COc1cc(Cl)ccc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4548635 pEC50 63.1 nM
COc1ncccc1C(=O)Nc1cc(C(=O)N(C)C)cnc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4441720 pEC50 63.1 nM
Cc1nccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)n1 CHEMBL4566638 pEC50 63.1 nM
COc1cncc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)n1 CHEMBL4593064 pEC50 63.1 nM
COc1ccc(CC2CCN(c3ccc(C#N)cc3NC(=O)c3cccn(C)c3=O)CC2)c(F)c1 CHEMBL4532889 pEC50 63.1 nM
Cn1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC(C(F)c3cc(F)ccc3F)CC2)c1=O CHEMBL4470569 pEC50 63.1 nM
Cn1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC([C@@H](F)c3ccc(F)cc3F)CC2)c1=O CHEMBL4534382 pEC50 63.1 nM
COc1cc(F)ccc1C(=O)Nc1cc(C#N)cnc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4450678 pEC50 63.1 nM
COc1cscc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4539191 pEC50 63.1 nM
COc1ccsc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4592881 pEC50 63.1 nM
COCc1cnc(N2CCN(Cc3ccc(F)cc3F)CC2)c(NC(=O)c2cccnc2OC)c1 CHEMBL4566121 pEC50 63.1 nM
Cn1cccc(C(=O)Nc2ccc(S(C)(=O)=O)cc2N2CCC(Oc3ccc(F)cc3F)CC2)c1=O CHEMBL4445602 pEC50 63.1 nM
Cn1cccc(C(=O)Nc2cnc(Cl)cc2N2CCC(Oc3ccc(F)cc3F)CC2)c1=O CHEMBL4587568 pEC50 63.1 nM
COc1ccc(OC2CCN(c3ccc(S(C)(=O)=O)cc3NC(=O)c3cn(CCF)nc3OC)CC2)c(F)c1 CHEMBL4436539 pEC50 63.1 nM
COc1ncccc1C(=O)Nc1cc(C#N)nnc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4435872 pEC50 63.1 nM
N#Cc1ccc2nc(NC3CC3)c(N3CCC(Cc4ccc(F)cc4F)CC3)nc2c1 CHEMBL3716625 IC50 64.0 nM
CN(C)C(=O)c1cc2nc(NCC(F)F)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2cn1 CHEMBL3718684 IC50 65.0 nM
N#Cc1nccc2nc(NC3CC3)c(N3CCN(Cc4ccc(F)cc4F)CC3)nc12 CHEMBL3717742 IC50 66.0 nM
Cc1cc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NC(C)C)nc2cn1 CHEMBL4789388 EC50 66.4 nM
O=C(c1ccccc1Cl)C1CCN(c2nc3cnccc3nc2NC2CC2)CC1 CHEMBL3715087 IC50 67.0 nM
N#Cc1ccc(F)c(C(=O)C2CCN(c3nc4cnccc4nc3NC3CC3)CC2)c1 CHEMBL3715605 IC50 69.0 nM
Cc1cc2nc(N[C@H]3C[C@@H](O)C3)c(N3CCN(Cc4ccc(F)cc4F)CC3)nc2cn1 CHEMBL4787484 EC50 69.3 nM
N#Cc1ccc2nc(NCC(F)F)c(N3CCC(Cc4ccc(F)cc4F)CC3)nc2c1 CHEMBL3718731 IC50 71.0 nM
Fc1ccc(CC2CCN(c3nc4cc(F)ccc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3715672 IC50 72.0 nM
CC(C)Nc1nc2cnncc2nc1N1CCC(Oc2ccc(C#N)cc2F)CC1 CHEMBL3718345 IC50 72.0 nM
N#Cc1ccc2nc(NC3CC3)c(N3CCC(C(F)c4cc(F)ccc4F)CC3)nc2c1 CHEMBL3718098 IC50 75.0 nM
Cc1cc2nc(N[C@H]3C[C@H](O)C3)c(N3CCN(Cc4ccc(F)cc4F)CC3)nc2cn1 CHEMBL4793353 EC50 75.2 nM
Cc1cc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(N[C@@H]3CCOC3)nc2cn1 CHEMBL4751107 EC50 76.3 nM
Fc1ccc(CC2CCN(c3nc4ccncc4nc3NCC(F)F)CC2)c(F)c1 CHEMBL3717670 IC50 78.0 nM
O=C(c1ccccc1Br)C1CCN(c2nc3cnccc3nc2NC2CC2)CC1 CHEMBL3718968 IC50 78.0 nM
COc1ncccc1C(=O)Nc1cc(C#N)c(C#N)cc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4456797 pEC50 79.43 nM
COc1ccncc1C(=O)Nc1cnc(C)cc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4462972 pEC50 79.43 nM
COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(Cc2ccc(F)c(F)c2)CC1 CHEMBL4461568 pEC50 79.43 nM
COc1cc(C)ccc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4463971 pEC50 79.43 nM
COc1ccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)c(OC)c1 CHEMBL4581158 pEC50 79.43 nM
COc1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)c1OC CHEMBL4437610 pEC50 79.43 nM
COc1nn(C)cc1C(=O)Nc1cc(C#N)cnc1N1CCN(Cc2c(F)cc(Cl)cc2F)CC1 CHEMBL4439159 pEC50 79.43 nM
COc1nn(C)cc1C(=O)Nc1cc(C#N)cnc1N1CCN(Cc2ccc(Cl)cc2F)CC1 CHEMBL4464492 pEC50 79.43 nM
COc1ccc(CN2CCN(c3ncc(C#N)cc3NC(=O)c3cn(C)nc3OC)CC2)c(F)c1 CHEMBL4590947 pEC50 79.43 nM
Cc1nc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)ccc1F CHEMBL4526029 pEC50 79.43 nM
COc1ccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)nc1 CHEMBL4563491 pEC50 79.43 nM
Cc1cncc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)n1 CHEMBL4587884 pEC50 79.43 nM
COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(Cc2ccc(F)cc2)CC1 CHEMBL4581259 pEC50 79.43 nM
COc1nc(C)ccc1C(=O)Nc1cnc(C)nc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4514061 pEC50 79.43 nM
COc1ncccc1C(=O)Nc1cc(C#N)cnc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4533351 pEC50 79.43 nM
COc1ncncc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4548974 pEC50 79.43 nM
COc1ncccc1C(=O)Nc1cnc(C(=O)N(C)C)cc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4442295 pEC50 79.43 nM
[2H]C([2H])([2H])N(C(=O)c1cc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cccnc2OC)cn1)C([2H])([2H])[2H] CHEMBL4456977 pEC50 79.43 nM
Cn1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3cc(F)ccc3F)CC2)c1=O CHEMBL4437908 pEC50 79.43 nM
COc1nc(C)ccc1C(=O)Nc1cnc(C#N)nc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4591516 pEC50 79.43 nM
Cc1cc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(NC(C)C)nc2cn1 CHEMBL4746978 EC50 80.1 nM
Cc1cc2nc(N[C@@H]3CCOC3)c(N3CCC(Oc4ccc(OC(F)F)cc4F)CC3)nc2cn1 CHEMBL4752926 EC50 81.4 nM
CC(C)Nc1nc2ccc(C#N)cc2nc1N1CCC([C@H](F)c2ccc(F)cc2F)CC1 CHEMBL3715833 IC50 82.0 nM
CC(C)Nc1nc2ccc(C#N)cc2nc1N1CCC([C@H](F)c2cc(F)ccc2F)CC1 CHEMBL4547891 IC50 82.0 nM
COc1ccc(CN2CCN(c3nc4c(C#N)nccc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3716751 IC50 88.0 nM
Cc1cc2nc(NC(C)C)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2cn1 CHEMBL4762823 EC50 88.2 nM
N#Cc1ccc(Cl)c(C(=O)C2CCN(c3nc4cnc(Cl)cc4nc3NC3CC3)CC2)c1 CHEMBL3714860 IC50 89.0 nM
N#Cc1ccc2nc(NC3CC3)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2c1 CHEMBL3719014 IC50 90.0 nM
N#Cc1ccc(OC2CCN(c3nc4cnncc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3718211 IC50 90.0 nM
CN(C)C(=O)c1ccc2nc(NC3CC3)c(N3CCN(Cc4cc(Cl)ccc4Cl)CC3)nc2c1 CHEMBL5077335 EC50 90.0 nM
COc1ccc(CN2CCN(c3nc4cnc(N5CCOCC5)cc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3715574 IC50 92.0 nM
COc1ccc(CN2CCN(c3nc4cnc(N5CCOCC5)cc4nc3NC3CC3)CC2)c(F)c1 CHEMBL4453567 IC50 92.0 nM
Cc1cc2nc(NC3CC3)c(N3CCC(S(=O)(=O)c4ccc(F)cc4)CC3)nc2cn1 CHEMBL3718817 IC50 93.0 nM
Cc1cc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NC3CC3)nc2cn1 CHEMBL4781329 EC50 94.9 nM
N#Cc1ccc2nc(NC3CC(=O)C3)c(N3CCN(Cc4cc(Cl)ccc4Cl)CC3)nc2c1 CHEMBL3717134 IC50 97.0 nM
CC(C)Nc1nc2ccc(C#N)cc2nc1N1CCC(C(F)c2cc(F)ccc2F)CC1 CHEMBL3717943 IC50 98.0 nM
O=C(/N=C1\SSC2=NCCN21)c1cccs1 CHEMBL3717663 IC50 100.0 nM
O=C(/N=C1\SSC2=NCCN21)c1ccccc1F CHEMBL3714791 IC50 100.0 nM
O=C(/N=C1\SSC2=NCCN21)c1ccno1 CHEMBL3717093 IC50 100.0 nM
Cn1cccc(C(=O)Nc2cc(S(=O)(=O)N3CCOCC3)cnc2N2CCC(Oc3ccc(F)cc3F)CC2)c1=O CHEMBL4540377 pEC50 100.0 nM
N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2ccc[nH]c2=O)c1 CHEMBL4437187 pEC50 100.0 nM
Cn1cccc(C(=O)Nc2ccccc2N2CCC(Oc3ccc(F)cc3F)CC2)c1=O CHEMBL4461704 pEC50 100.0 nM
CCNC(=O)c1cc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cccnc2OC)cn1 CHEMBL4562967 pEC50 100.0 nM
COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(Cc2ccccc2C#N)CC1 CHEMBL4461245 pEC50 100.0 nM
COc1cc(Br)ccc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4459171 pEC50 100.0 nM
COc1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)n1 CHEMBL4586098 pEC50 100.0 nM
Cc1onc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)c1C CHEMBL4463278 pEC50 100.0 nM
N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2ncccc2F)c1 CHEMBL4517992 pEC50 100.0 nM
Cc1nc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)cs1 CHEMBL4463584 pEC50 100.0 nM
Cn1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC(C(=O)c3cc(F)ccc3F)CC2)c1=O CHEMBL4448613 pEC50 100.0 nM
N#Cc1cnc(N2CCC(Oc3ccccc3)CC2)c(NC(=O)c2ccccn2)c1 CHEMBL4466414 pEC50 100.0 nM
COc1ncccc1C(=O)Nc1cc(CNC(C)=O)cnc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4563440 pEC50 100.0 nM
COc1nn(C)cc1C(=O)Nc1cc(C)cnc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4582790 pEC50 100.0 nM
COc1ncccc1C(=O)Nc1cc(CO)cnc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4469138 pEC50 100.0 nM
COc1ncc(F)cc1C(=O)Nc1cnc(C(=O)N(C)C)cc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4458016 pEC50 100.0 nM
COc1cnccc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4483436 pEC50 100.0 nM
COc1ccc(OC2CCN(c3ccc(S(C)(=O)=O)cc3NC(=O)c3cn(CF)nc3OC)CC2)c(F)c1 CHEMBL4472092 pEC50 100.0 nM
Cc1cc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(N[C@@H]3CCOC3)nc2cn1 CHEMBL4764749 EC50 101.7 nM
O=C(NC(=S)N1CCNC1=S)c1ccc(F)cc1F CHEMBL3717450 IC50 110.0 nM
O=C(/N=C1\SSC2=NCCN21)c1ccco1 CHEMBL3718261 IC50 110.0 nM
COc1ccc(OC2CCN(c3nc4c(N5CCOCC5)nccc4nc3NC3CC3)CC2)c(F)c1 CHEMBL4456991 IC50 114.0 nM
Fc1ccc(F)c(CN2CCN(c3nc4cnccc4nc3NC3CC3)CC2)c1 CHEMBL3716373 IC50 120.0 nM
COc1ncccc1C(=O)Nc1cnc(C#N)cc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4558548 pEC50 125.89 nM
COc1ncccc1C(=O)Nc1cnc(C(N)=O)cc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4459325 pEC50 125.89 nM
COCc1cc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cccnc2OC)cn1 CHEMBL4448053 pEC50 125.89 nM
COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(Cc2cccc(C#N)c2)CC1 CHEMBL4440020 pEC50 125.89 nM
COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(Cc2ccccc2F)CC1 CHEMBL4459010 pEC50 125.89 nM
COc1ccc(C(F)(F)F)cc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4569037 pEC50 125.89 nM
N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cnc3sccn3c2=O)c1 CHEMBL4453376 pEC50 125.89 nM
COc1ncc(C)cc1C(=O)Nc1cc(C(=O)N(C)C)cnc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4591540 pEC50 125.89 nM
COc1nccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)n1 CHEMBL4537146 pEC50 125.89 nM
Cc1ccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)nc1 CHEMBL4453274 pEC50 125.89 nM
Cc1cc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)nn1C CHEMBL4572823 pEC50 125.89 nM
Cn1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC(C(=O)c3cc(Cl)ccc3F)CC2)c1=O CHEMBL4524681 pEC50 125.89 nM
COc1ccc(C(=O)C2CCN(c3ccc(C#N)cc3NC(=O)c3cccn(C)c3=O)CC2)c(F)c1 CHEMBL4522800 pEC50 125.89 nM
COc1ccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)c(OC)n1 CHEMBL4590752 pEC50 125.89 nM
Cn1ccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)n1 CHEMBL4447854 pEC50 125.89 nM
COc1cc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cccnc2OC)cn1 CHEMBL4534642 pEC50 125.89 nM
COc1c(F)cccc1C(=O)Nc1cc(S(C)(=O)=O)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4552177 pEC50 125.89 nM
Cn1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccccc3F)CC2)c1=O CHEMBL4533769 pEC50 125.89 nM
COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(C(=O)c2ccc(Cl)cc2)CC1 CHEMBL4446654 pEC50 125.89 nM
COc1ncccc1C(=O)Nc1cnc(C(F)(F)F)cc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4580036 pEC50 125.89 nM
COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(Cc2ccc(F)cc2C#N)CC1 CHEMBL4524891 pEC50 125.89 nM
Cc1cc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(N[C@H]3CCOC3)nc2cn1 CHEMBL4756654 EC50 128.0 nM
O=C(/N=C1\SSC2=NCCN21)c1cc2ccccc2s1 CHEMBL3715886 IC50 130.0 nM
O=C(/N=C1\SSC2=NCCN21)c1cccc2ccccc12 CHEMBL3716276 IC50 130.0 nM
O=C(/N=C1\SSC2=NCCN21)c1cccnc1 CHEMBL3716809 IC50 133.0 nM
Cc1cccc(C(=O)/N=C2\SSC3=NCCN32)c1 CHEMBL3719216 IC50 140.0 nM
Fc1ccc(CC2CCN(c3nc4cc(F)c(F)cc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3717737 IC50 140.0 nM
Fc1ccc(F)c(CN2CCN(c3nc4ccncc4nc3NC3CC3)CC2)c1 CHEMBL3717716 IC50 140.0 nM
C[C@@H]1C[C@H]1Nc1nc2cnncc2nc1N1CCC([C@@H](F)c2ccc(F)cc2F)CC1 CHEMBL3715332 IC50 145.0 nM
CC1CC1Nc1nc2cnncc2nc1N1CCC([C@@H](F)c2ccc(F)cc2F)CC1 CHEMBL4462716 IC50 145.0 nM
CSc1ccc(OC2CCN(c3nc4cnccc4nc3NC3CC3)CC2)cc1 CHEMBL3719166 IC50 146.0 nM
COc1ccc(CN2CCN(c3nc4cnc(C)cc4nc3NC3CC3)CC2)c(F)c1 CHEMBL4760027 EC50 158.1 nM
COc1nn(C)cc1C(=O)Nc1cc(C#N)ncc1N1CCN(Cc2ccc(F)c(F)c2F)CC1 CHEMBL4472418 pEC50 158.49 nM
COc1ncccc1C(=O)Nc1cnccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4573664 pEC50 158.49 nM
COc1ncccc1C(=O)Nc1cnc(C(=O)NC(C)C)cc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4438700 pEC50 158.49 nM
COc1ncccc1C(=O)Nc1cnc(C(=O)N[C@@H]2CCOC2)cc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4467741 pEC50 158.49 nM
COc1ccc(F)c(CN2CCN(c3ccc(C#N)cc3NC(=O)c3cccnc3OC)CC2)c1 CHEMBL4571240 pEC50 158.49 nM
COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(Cc2cccc(F)c2)CC1 CHEMBL4465649 pEC50 158.49 nM
Cc1csc2ncc(C(=O)Nc3cc(C#N)ccc3N3CCC(Oc4ccc(F)cc4F)CC3)c(=O)n12 CHEMBL4548020 pEC50 158.49 nM
COc1nc(C(F)(F)F)ccc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4444435 pEC50 158.49 nM
COc1c(F)cc(F)cc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4539747 pEC50 158.49 nM
Cc1ccc2ncc(C(=O)Nc3cc(C#N)ccc3N3CCC(Oc4ccc(F)cc4F)CC3)c(=O)n2c1 CHEMBL4440533 pEC50 158.49 nM
COc1nc(Cl)ccc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4566640 pEC50 158.49 nM
Cc1cc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)c(=O)n(C)c1C CHEMBL4456317 pEC50 158.49 nM
N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cnc3ccccn3c2=O)c1 CHEMBL4542974 pEC50 158.49 nM
COc1nn(C)cc1C(=O)Nc1cc(C#N)cnc1N1CCN(Cc2c(F)cc(F)cc2F)CC1 CHEMBL4584701 pEC50 158.49 nM
CCn1nc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)cc1C CHEMBL4442531 pEC50 158.49 nM
COc1ccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)nn1 CHEMBL4528618 pEC50 158.49 nM
Cc1cc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)nc(C)n1 CHEMBL4450514 pEC50 158.49 nM
COc1ncc(F)cc1C(=O)Nc1ccc(C)nc1N1CCN(Cc2ccc(F)cc2)CC1 CHEMBL4589311 pEC50 158.49 nM
Cn1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC(C(F)(F)c3ccc(F)cc3F)CC2)c1=O CHEMBL4576358 pEC50 158.49 nM
Cc1ccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)c(=O)n1C CHEMBL4465417 pEC50 158.49 nM
Cc1csc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)n1 CHEMBL4472804 pEC50 158.49 nM
N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cc3cccn3cn2)c1 CHEMBL4471617 pEC50 158.49 nM
CS(=O)(=O)c1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cnn3c2OCCCC3)c1 CHEMBL4543560 pEC50 158.49 nM
COc1ncccc1C(=O)Nc1cnc(C)nc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4514969 pEC50 158.49 nM
COc1nc(C)ccc1C(=O)Nc1cnc(C(=O)N(C)C)cc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4466976 pEC50 158.49 nM
N#Cc1ccc2nc(NCCC(F)(F)F)c(N3CCC(Oc4ccc(F)cc4F)CC3)nc2c1 CHEMBL3715587 IC50 160.0 nM
Cc1cc2nc(N[C@H]3CCOC3)c(N3CCC(Oc4ccc(OC(F)F)cc4F)CC3)nc2cn1 CHEMBL4795661 EC50 162.2 nM
Cc1cc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(NC3COC3)nc2cn1 CHEMBL4760952 EC50 163.7 nM
O=C(/N=C1\SSC2=NCCN21)c1ccc2ccccc2c1 CHEMBL3718681 IC50 170.0 nM
O=C(/N=C1\SSC2=NCCN21)c1ccccc1 CHEMBL3719346 IC50 170.0 nM
O=C(/N=C1\SSC2=NCCN21)c1ccc(C(F)(F)F)cc1 CHEMBL3716631 IC50 170.0 nM
Fc1cc(F)c(OC2CCN(c3nc4cnccc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3715352 IC50 170.0 nM
N#Cc1ccc2nc(N3CCN(Cc4cc(Cl)ccc4Cl)CC3)c(NC3CC3)nc2c1 CHEMBL5094307 EC50 174.0 nM
Cc1cc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(NC3CC3)nc2cn1 CHEMBL4788555 EC50 188.0 nM
O=C(/N=C1\SSC2=NCCN21)c1cnn(-c2ccc(Cl)cc2)c1C(F)(F)F CHEMBL3716172 IC50 189.7 nM
O=C(/N=C1\SSC2=NCCN21)c1ccc(F)cc1F CHEMBL3719079 IC50 190.0 nM
COc1ccc(OC2CCN(c3nc4cnccc4nc3NC3CC3)CC2)cc1 CHEMBL3716306 IC50 190.0 nM
COc1ncccc1C(=O)Nc1cc(C(=O)N(C)C)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4583395 pEC50 199.53 nM
COc1c(C(=O)Nc2ccc(C#N)nc2N2CCC(Oc3ccc(F)cc3F)CC2)cnn1C CHEMBL4559451 pEC50 199.53 nM
COc1ccc(C)cc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4448809 pEC50 199.53 nM
COc1c(Cl)cccc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4464396 pEC50 199.53 nM
Cc1cn2c(=O)c(C(=O)Nc3cc(C#N)ccc3N3CCC(Oc4ccc(F)cc4F)CC3)cnc2s1 CHEMBL4450498 pEC50 199.53 nM
COc1ccc(Cl)cc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4447944 pEC50 199.53 nM
Cc1cccn2c(=O)c(C(=O)Nc3cc(C#N)ccc3N3CCC(Oc4ccc(F)cc4F)CC3)cnc12 CHEMBL4584951 pEC50 199.53 nM
COc1nc2c(cc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc3ccc(F)cc3F)CC1)CCC2 CHEMBL4474249 pEC50 199.53 nM
COc1nn(C)cc1C(=O)Nc1cc(C#N)cnc1N1CCN(Cc2cccc(OC(F)(F)F)c2)CC1 CHEMBL4536457 pEC50 199.53 nM
COc1nn(C)cc1C(=O)Nc1cc(C#N)cnc1N1CCN(Cc2ccccc2OC(F)F)CC1 CHEMBL4577031 pEC50 199.53 nM
COc1ccc(CN2CCN(c3ncc(C#N)cc3NC(=O)c3cn(C)nc3OC)CC2)cc1 CHEMBL4588701 pEC50 199.53 nM
N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cc(C3CC3)on2)c1 CHEMBL4441453 pEC50 199.53 nM
CCOc1c(C(=O)Nc2cc(C#N)cnc2N2CCC(Oc3ccc(F)cc3F)CC2)cnn1C CHEMBL4551046 pEC50 199.53 nM
COc1ccnc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)c1 CHEMBL4469082 pEC50 199.53 nM
Cc1ccc(SC2CCN(c3ncc(C#N)cc3NC(=O)c3ccccn3)CC2)cc1 CHEMBL4475574 pEC50 199.53 nM
CNC(=O)c1cc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cccnc2OC)cn1 CHEMBL4458506 pEC50 199.53 nM
COc1cccc(F)c1C(=O)Nc1cc(S(C)(=O)=O)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4586597 pEC50 199.53 nM
Cn1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3)CC2)c1=O CHEMBL4448961 pEC50 199.53 nM
COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(C(=O)c2ccc(F)cc2)CC1 CHEMBL4534886 pEC50 199.53 nM
O=C(/N=C1\SSC2=NCCN21)c1ccc(F)cc1 CHEMBL3716284 IC50 200.0 nM
O=C(c1c(F)cc(Cl)cc1F)C1CCN(c2nc3cnccc3nc2NC2CC2)CC1 CHEMBL3716288 IC50 200.0 nM
COc1ccc(C(=O)/N=C2\SSC3=NCCN32)cc1 CHEMBL3715031 IC50 210.0 nM
O=C(/N=C1\SSC2=NCCN21)c1cccc(F)c1 CHEMBL3716570 IC50 220.0 nM
Fc1ccc(CN2CCN(c3nc4ccncc4nc3NCC(F)F)CC2)c(F)c1 CHEMBL3716577 IC50 230.0 nM
N#Cc1ccc2nc(NC3CC3)c(N3CCN(Cc4cc(Cl)ccc4Cl)CC3)nc2c1 CHEMBL3717781 IC50 250.0 nM
COCCNc1nc2ccc(C#N)cc2nc1N1CCC(Cc2ccc(F)cc2F)CC1 CHEMBL3718445 IC50 250.0 nM
Cc1cccc2ncc(C(=O)Nc3cc(C#N)ccc3N3CCC(Oc4ccc(F)cc4F)CC3)c(=O)n12 CHEMBL4453398 pEC50 251.19 nM
COc1nn(C)cc1C(=O)Nc1cc(C#N)cnc1N1CCN(Cc2c(F)cc(F)c(OC)c2F)CC1 CHEMBL4457711 pEC50 251.19 nM
COc1nn(C)cc1C(=O)Nc1cc(C#N)cnc1N1CCN(Cc2ccc(OC(F)F)cc2)CC1 CHEMBL4437230 pEC50 251.19 nM
Cc1ccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)nn1 CHEMBL4566081 pEC50 251.19 nM
Cn1cc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)nn1 CHEMBL4475585 pEC50 251.19 nM
N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2ccsn2)c1 CHEMBL4569679 pEC50 251.19 nM
Cc1nccnc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4452371 pEC50 251.19 nM
N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cc3n(n2)CCC3)c1 CHEMBL4455649 pEC50 251.19 nM
Cn1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC([C@H](F)c3ccc(F)cc3F)CC2)c1=O CHEMBL4435590 pEC50 251.19 nM
COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(Cc2cccs2)CC1 CHEMBL4528596 pEC50 251.19 nM
Cc1ccc(Cl)c(OC2CCN(c3ncc(C#N)cc3NC(=O)c3ccccn3)CC2)c1 CHEMBL4460044 pEC50 251.19 nM
Cn1cnc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)c1 CHEMBL4452862 pEC50 251.19 nM
CCOc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4466778 pEC50 251.19 nM
Cn1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)c(F)c3)CC2)c1=O CHEMBL4444492 pEC50 251.19 nM
COc1ccc(C(=O)N2CCN(c3ccc(C#N)cc3NC(=O)c3cccnc3OC)CC2)c(F)c1 CHEMBL4578251 pEC50 251.19 nM
Cn1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3cc(F)cnc3F)CC2)c1=O CHEMBL4590260 pEC50 251.19 nM
Cn1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ncc(F)cc3F)CC2)c1=O CHEMBL4450608 pEC50 251.19 nM
O=C(NC(=S)N1CCNC1=S)c1cc2ccccc2s1 CHEMBL3717282 IC50 260.0 nM
Fc1ccc(CN2CCN(c3nc4cnncc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3717615 IC50 260.0 nM
O=C(/N=C1\SSC2=NCCN21)c1ccc(Cl)cc1 CHEMBL3716432 IC50 270.0 nM
FC(F)Oc1ccc(Cl)cc1CN1CCN(c2nc3cnccc3nc2NC2CC2)CC1 CHEMBL3718558 IC50 270.0 nM
COc1ccc(CN2CCN(c3nc4cc(C)ncc4nc3NC(C)C)CC2)c(F)c1 CHEMBL4778768 EC50 275.6 nM
CC(C)Nc1cc(Cl)cc(C(=O)C2CCN(c3nc4ccc(C#N)cc4nc3NC(C)C)CC2)c1 CHEMBL3716695 IC50 276.0 nM
COc1ccc(CN2CCN(c3nc4cnc(C)cc4nc3N[C@H]3CCOC3)CC2)c(F)c1 CHEMBL4798837 EC50 277.8 nM
N#Cc1ccc2nc(NC3CCC3)c(N3CCN(C(=O)c4ccc(Cl)cc4)CC3)nc2c1 CHEMBL3715157 IC50 300.0 nM
Cc1cc2nc(N3CCC(Oc4ccc(OC(F)F)cc4F)CC3)c(NC(C)C)nc2cn1 CHEMBL4796050 EC50 309.0 nM
COc1cccc(C(=O)/N=C2\SSC3=NCCN32)c1 CHEMBL3716937 IC50 310.0 nM
Clc1ccc(OC2CCN(c3nc4cnccc4nc3NC3CC3)CC2)cc1 CHEMBL3716289 IC50 310.0 nM
CC(C)Nc1nc2ccc(C#N)cc2nc1N1CCN(Cc2cc(F)ccc2F)CC1 CHEMBL3717038 IC50 310.0 nM
CC(C)Nc1nc2ccc(C#N)cc2nc1N1CCN(Cc2cc(Cl)ccc2Cl)CC1 CHEMBL4562806 IC50 310.0 nM
COc1ccc(CN2CCN(c3nc4cnc(C)cc4nc3N[C@@H]3CCOC3)CC2)c(F)c1 CHEMBL4779367 EC50 311.2 nM
N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cccn(C(F)F)c2=O)c1 CHEMBL4524783 pEC50 316.23 nM
N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2ccccc2O)c1 CHEMBL4572032 pEC50 316.23 nM
COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(Cc2cccc(F)c2F)CC1 CHEMBL4535266 pEC50 316.23 nM
COc1cc(Cl)c(Cl)cc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4536088 pEC50 316.23 nM
Cc1cc(C)n(C)c(=O)c1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4452334 pEC50 316.23 nM
COc1cc(F)c(F)cc1CN1CCN(c2ncc(C#N)cc2NC(=O)c2cn(C)nc2OC)CC1 CHEMBL4575405 pEC50 316.23 nM
COc1nn(C)cc1C(=O)Nc1cc(C#N)cnc1N1CCN(Cc2ccccc2OC(F)(F)F)CC1 CHEMBL4465687 pEC50 316.23 nM
COc1nn(C)cc1C(=O)Nc1cc(C#N)cnc1N1CCN(Cc2cccc(OC(F)F)c2)CC1 CHEMBL4446936 pEC50 316.23 nM
COc1ccc(F)cc1CN1CCN(c2ncc(C#N)cc2NC(=O)c2cn(C)nc2OC)CC1 CHEMBL4542790 pEC50 316.23 nM
COc1nn(C)cc1C(=O)Nc1cc(C#N)cnc1N1CCN(Cc2cccc(F)c2OC)CC1 CHEMBL4474630 pEC50 316.23 nM
COc1nn(C)cc1C(=O)Nc1cc(C#N)cnc1N1CCN(Cc2ccc(F)c(C#N)c2)CC1 CHEMBL4576699 pEC50 316.23 nM
Cc1cnc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)cn1 CHEMBL4574512 pEC50 316.23 nM
N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2ccc(F)cn2)c1 CHEMBL4469694 pEC50 316.23 nM
COc1c(C(=O)Nc2ccc(C)nc2N2CCN(Cc3ccc(F)cc3)CC2)cnn1C CHEMBL4466902 pEC50 316.23 nM
COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCC(C(OC)c2ccc(F)cc2)CC1 CHEMBL4593136 pEC50 316.23 nM
COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(Cc2ccsc2)CC1 CHEMBL4444254 pEC50 316.23 nM
COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(Cc2c(F)cccc2Cl)CC1 CHEMBL4453400 pEC50 316.23 nM
N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2ncc(F)cc2F)c1 CHEMBL4436944 pEC50 316.23 nM
COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(Cc2ncc(F)cc2F)CC1 CHEMBL4578942 pEC50 316.23 nM
Cc1cc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(N[C@H]3CCOC3)nc2cn1 CHEMBL4787130 EC50 326.0 nM
N#Cc1ccc2nc(N3CCN(C(=O)c4ccc(Cl)cc4)CC3)c(NC3CC3)nc2c1 CHEMBL3717270 IC50 340.0 nM
COCCNc1nc2ccc(C#N)cc2nc1N1CCC(C(F)c2ccc(F)cc2F)CC1 CHEMBL3717101 IC50 340.0 nM
Cc1noc(C)c1C(=O)/N=C1\SSC2=NCCN21 CHEMBL3715342 IC50 350.0 nM
CC(C)(C)c1ccc(C(=O)/N=C2\SSC3=NCCN32)cc1 CHEMBL3715193 IC50 370.0 nM
Cc1ccc(C)c(CN2CCN(c3nc4cnccc4nc3NC3CC3)CC2)c1 CHEMBL3716802 IC50 380.0 nM
N#Cc1ccc2nc(NC3CC3)c(N3CCN(Cc4cc(F)ccc4F)CC3)nc2c1 CHEMBL3717221 IC50 380.0 nM
Cc1nccc2nc(NC3CC3)c(N3CCC(Cn4ccc(F)cc4=O)CC3)nc12 CHEMBL3715463 IC50 380.0 nM
Cc1nccc2nc(NC3CC3)c(N3CCC(Cn4ccc(F)cc4=O)CC3)nc12 CHEMBL4593290 IC50 380.0 nM
N#Cc1ccc2nc(NCCC(F)(F)F)c(N3CCN(Cc4ccc(F)cc4F)CC3)nc2c1 CHEMBL3718568 IC50 390.0 nM
N#Cc1ccc2nc(Nc3cccnc3)c(N3CCC(Cc4ccc(F)cc4F)CC3)nc2c1 CHEMBL3716107 IC50 390.0 nM
COc1nn(C)cc1C(=O)Nc1cc(C#N)ncc1N1CCN(Cc2cc(F)c(F)c(F)c2)CC1 CHEMBL4527677 pEC50 398.11 nM
COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(Cc2c(F)cccc2F)CC1 CHEMBL4530385 pEC50 398.11 nM
COc1c(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)ccc(F)c1F CHEMBL4434982 pEC50 398.11 nM
COc1c(C)cccc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4549409 pEC50 398.11 nM
COc1ccc(Br)cc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4556641 pEC50 398.11 nM
COc1cc(C(C)(C)C)ccc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4590552 pEC50 398.11 nM
Cc1sc2ncc(C(=O)Nc3cc(C#N)ccc3N3CCC(Oc4ccc(F)cc4F)CC3)c(=O)n2c1C CHEMBL4476744 pEC50 398.11 nM
COc1cc(N(C)C)ccc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4588321 pEC50 398.11 nM
CC(C)c1ccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)c(=O)n1C CHEMBL4526142 pEC50 398.11 nM
Cn1c2c(cc(C(=O)Nc3cc(C#N)ccc3N3CCC(Oc4ccc(F)cc4F)CC3)c1=O)CCCC2 CHEMBL4592263 pEC50 398.11 nM
CC(C)n1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)c1=O CHEMBL4469561 pEC50 398.11 nM
COc1nn(C)cc1C(=O)Nc1cc(C#N)cnc1N1CCN(Cc2cc(F)cc(F)c2)CC1 CHEMBL4514274 pEC50 398.11 nM
COc1ccc(CN2CCN(c3ncc(C#N)cc3NC(=O)c3cn(C)nc3OC)CC2)cc1F CHEMBL4554272 pEC50 398.11 nM
COc1cccc(CN2CCN(c3ncc(C#N)cc3NC(=O)c3cn(C)nc3OC)CC2)c1 CHEMBL4461050 pEC50 398.11 nM
COc1nn(C)cc1C(=O)Nc1cc(C#N)cnc1N1CCN(Cc2ccc(C#N)cc2)CC1 CHEMBL4533773 pEC50 398.11 nM
CCc1cc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)no1 CHEMBL4472427 pEC50 398.11 nM
N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cscn2)c1 CHEMBL4476148 pEC50 398.11 nM
COc1cccc(S(=O)(=O)C2CCN(c3ccc(C#N)cc3NC(=O)c3cn(C)nc3OC)CC2)c1 CHEMBL4468257 pEC50 398.11 nM
COc1nn(C)cc1C(=O)Nc1cc(C#N)ccc1N1CCC(S(=O)(=O)c2cccc(F)c2)CC1 CHEMBL4528260 pEC50 398.11 nM
Cn1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC(C(F)(F)c3cc(F)ccc3F)CC2)c1=O CHEMBL4472339 pEC50 398.11 nM
COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCC(C(=O)c2ccccc2)CC1 CHEMBL4582710 pEC50 398.11 nM
N#Cc1cnc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cnccc2O)c1 CHEMBL4570463 pEC50 398.11 nM
Cc1cc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)no1 CHEMBL4471697 pEC50 398.11 nM
COc1cccnc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4452273 pEC50 398.11 nM
Cn1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3cccc(F)c3)CC2)c1=O CHEMBL4526570 pEC50 398.11 nM
COc1ncccc1C(=O)Nc1cnc(C(=O)N(C)C)nc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4446569 pEC50 398.11 nM
Fc1cc(F)c(CN2CCN(c3nc4ccncc4nc3Nc3cccnc3)CC2)cc1F CHEMBL3719149 IC50 400.0 nM
N#Cc1ccc2nc(NC3CC3)c(N3CCN(S(=O)(=O)c4ccc(Br)s4)CC3)nc2c1 CHEMBL3717828 IC50 420.0 nM
N#Cc1ccc2nc(N3CCN(Cc4cc(Cl)ccc4Cl)CC3)c(Nc3cccnc3)nc2c1 CHEMBL3716941 IC50 440.0 nM
Cc1cc2nc(NC3CC3)c(N3CCN(Cc4ccc(OC(F)F)cc4F)CC3)nc2cn1 CHEMBL4796941 EC50 446.3 nM
O=C(NC(=S)N1CCNC1=S)c1ccc(Cl)cc1 CHEMBL3718421 IC50 450.0 nM
Cc1cc(S(=O)(=O)N2CCN(c3nc4cc(C#N)ccc4nc3NC3CC3)CC2)c(C)cc1Cl CHEMBL3717775 IC50 450.0 nM
Cc1cc2nc(NC(C)C)c(N3CCN(Cc4ccc(OC(F)F)cc4F)CC3)nc2cn1 CHEMBL4764448 EC50 466.2 nM
CSc1ccc(F)c(C(=O)C2CCN(c3nc4cnccc4nc3NC3CC3)CC2)c1 CHEMBL3717660 IC50 478.0 nM
O=C(NC(=S)N1CCNC1=S)c1ccc(F)cc1 CHEMBL3716955 IC50 480.0 nM
COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(Cc2ccc(F)cn2)CC1 CHEMBL4543637 pEC50 501.19 nM
COc1ccc(OC(F)(F)F)cc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4450234 pEC50 501.19 nM
COc1cn(-c2ccccc2)nc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4583665 pEC50 501.19 nM
CCn1c(C)cc(C)c(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)c1=O CHEMBL4474503 pEC50 501.19 nM
COc1cc(C(F)(F)F)ccc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4464196 pEC50 501.19 nM
COc1ccc(F)c(F)c1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4517745 pEC50 501.19 nM
CC(C)n1cc(Br)cc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)c1=O CHEMBL4438716 pEC50 501.19 nM
COc1cc(CN2CCN(c3ncc(C#N)cc3NC(=O)c3cn(C)nc3OC)CC2)ccc1F CHEMBL4459007 pEC50 501.19 nM
COc1cc(F)ccc1CN1CCN(c2ncc(C#N)cc2NC(=O)c2cn(C)nc2OC)CC1 CHEMBL4557859 pEC50 501.19 nM
COc1nn(C)cc1C(=O)Nc1cc(C#N)cnc1N1CCN(Cc2cc(C#N)ccc2F)CC1 CHEMBL4464100 pEC50 501.19 nM
N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cccnn2)c1 CHEMBL4548561 pEC50 501.19 nM
N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2ccon2)c1 CHEMBL4518709 pEC50 501.19 nM
Cc1nc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)c(C)o1 CHEMBL4539765 pEC50 501.19 nM
COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(C(=O)c2ccc(F)cc2F)CC1 CHEMBL4448934 pEC50 501.19 nM
Cn1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC(C(F)(F)c3cc(Cl)ccc3F)CC2)c1=O CHEMBL4515672 pEC50 501.19 nM
COc1nc(C)cc(C)c1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4461646 pEC50 501.19 nM
N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cnn3c2OCCC3)c1 CHEMBL4444745 pEC50 501.19 nM
COc1ncc(NC(=O)c2ccc(C)nc2OC)c(N2CCC(Oc3ccc(F)cc3F)CC2)n1 CHEMBL4534917 pEC50 501.19 nM
Cn1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3c(F)cccc3F)CC2)c1=O CHEMBL4539539 pEC50 501.19 nM
CS(=O)(=O)c1ccc(C(=O)N2CCN(c3nc4ccccc4nc3NC3CC3)CC2)cc1 CHEMBL3716133 IC50 530.0 nM
CC(C)(C)Nc1nc2cc(C#N)ncc2nc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL3718095 IC50 538.0 nM
N#Cc1ccc2nc(NC3CC3)c(N3CCN(S(=O)(=O)c4ccc(Cl)cc4)CC3)nc2c1 CHEMBL3717213 IC50 570.0 nM
CCCCn1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)c1=O CHEMBL4469078 pEC50 630.96 nM
COc1cnc(C(=O)Nc2cnc(C)cc2N2CCC(Oc3ccc(F)cc3F)CC2)cn1 CHEMBL4550472 pEC50 630.96 nM
COc1ncccc1C(=O)Nc1cc(S(C)(=O)=O)ccc1N1CCN(C(=O)c2ccc(F)cc2C)CC1 CHEMBL4449743 pEC50 630.96 nM
N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2ccc(O)nn2)c1 CHEMBL4455418 pEC50 630.96 nM
Cn1ccnc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4463816 pEC50 630.96 nM
N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cnccn2)c1 CHEMBL4464154 pEC50 630.96 nM
COc1ncccc1C(=O)Nc1cnc(C)cc1N1CCC(Oc2ccc(C#N)cc2F)CC1 CHEMBL4451592 pEC50 630.96 nM
Cc1cc(=O)c(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)cn1C CHEMBL4461586 pEC50 630.96 nM
COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(S(=O)(=O)c2ccc(F)cc2)CC1 CHEMBL4549386 pEC50 630.96 nM
N#Cc1cccc2nc(NC3CC3)c(N3CCN(Cc4cc(Cl)ccc4Cl)CC3)nc12 CHEMBL3717284 IC50 650.0 nM
COCCNc1nc2ccncc2nc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL3717374 IC50 670.0 nM
O=C(NC(=S)N1CCNC1=S)c1ccc2ccccc2c1 CHEMBL3718566 IC50 710.0 nM
COc1ccc(C(=O)C2CCN(c3nc4c(N5CCOCC5)nccc4nc3NC3CC3)CC2)c(F)c1 CHEMBL4440979 IC50 717.0 nM
Cc1cc(C(=O)N2CCN(c3nc4ccccc4nc3NC3CC3)CC2)ccc1Cl CHEMBL3717634 IC50 720.0 nM
Cc1cc2nc(NC3CC3)c(N3CCC(Cn4cc(Cl)ccc4=O)CC3)nc2cn1 CHEMBL3715860 IC50 770.0 nM
Cc1cc2nc(NC3CC3)c(N3CCC(Cn4cc(Cl)ccc4=O)CC3)nc2cn1 CHEMBL4455795 IC50 770.0 nM
COc1ccc(C(C)(C)C)cc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4556332 pEC50 794.33 nM
COc1nn(C)cc1C(=O)Nc1cc(C#N)cnc1N1CCN(Cc2ccc(OC(F)(F)F)cc2)CC1 CHEMBL4472961 pEC50 794.33 nM
Cc1ocnc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 CHEMBL4443168 pEC50 794.33 nM
N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cocn2)c1 CHEMBL4552378 pEC50 794.33 nM
Cc1cnc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)c(C)n1 CHEMBL4461647 pEC50 794.33 nM
COc1nn(C)cc1C(=O)Nc1cc(C)cnc1N1CCN(Cc2ccc(C#N)c(F)c2)CC1 CHEMBL4437808 pEC50 794.33 nM
COc1nn(C)cc1C(=O)Nc1cnc(C)cc1N1CCC(S(=O)(=O)c2ccc(F)cc2F)CC1 CHEMBL4454615 pEC50 794.33 nM
Cc1nc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)co1 CHEMBL4563101 pEC50 794.33 nM
Cn1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3cccc(F)c3F)CC2)c1=O CHEMBL4476723 pEC50 794.33 nM
Fc1cc2nc(NC3CC3)c(N3CCN(Cc4cc(Cl)ccc4Cl)CC3)nc2cc1F CHEMBL3717824 IC50 800.0 nM
Cc1cccc(CN2CCN(c3nc4ncccc4nc3NC3CC3)CC2)c1 CHEMBL3715318 IC50 840.0 nM
O=C(NC(=S)N1CCNC1=S)c1cccnc1 CHEMBL3718287 IC50 850.0 nM
N#Cc1ccc2nc(NC3CC3)c(N3CCC(Cn4cc(Cl)ccc4=O)CC3)nc2c1 CHEMBL3718559 IC50 930.0 nM
COc1ccc(CN2CCN(c3nc4cnc(C(=O)N(C)C)cc4nc3NC3CC3)CC2)c(F)c1 CHEMBL3719320 IC50 939.0 nM
N#Cc1ccc2nc(NCCF)c(N3CCN(C(=O)c4ccc(Cl)cc4)CC3)nc2c1 CHEMBL3715152 IC50 960.0 nM
Cc1c(Cl)cc(F)cc1S(=O)(=O)N1CCN(c2nc3cc(C#N)ccc3nc2NC2CC2)CC1 CHEMBL3715022 IC50 960.0 nM