O=S1(=O)NCN(C2CC2)c2cc(CCc3ccc4c(c3)N(C3CC3)CNS4(=O)=O)ccc21 CHEMBL4218628 pEC50 1.259 nM
COc1cccc(Oc2ccc3c(c2)S(=O)(=O)NCN3C2CC2)c1 CHEMBL4091984 pEC50 1.995 nM
O=C(O)[C@@H]1C[C@H]2C[C@@H](Oc3cc(-c4ccc(Cl)cc4)ccc3-c3nnn[nH]3)CC[C@H]2CN1 CHEMBL3088070 Ki 3.0 nM
Cn1nnc(-c2onc(O)c2C[C@H](N)C(=O)O)n1 CHEMBL370038 Ki 3.89 nM
CN1CNS(=O)(=O)c2ccc(CCc3ccc4c(c3)N(C)CNS4(=O)=O)cc21 CHEMBL4202524 EC50 13.4 nM
N[C@@H](Cn1nc(Cl)c(=O)[nH]c1=O)C(=O)O CHEMBL331696 Ki 16.7 nM
Cc1onc(O)c1C[C@H](N)C(=O)O CHEMBL276815 Ki 16.8 nM
Cc1onc(O)c1CC(N)C(=O)O CHEMBL13378 Ki 17.0 nM
N[C@@H](Cn1nc(Br)c(=O)[nH]c1=O)C(=O)O CHEMBL331644 Ki 19.3 nM
N[C@@H](Cn1cc(F)c(=O)[nH]c1=O)C(=O)O CHEMBL123132 Ki 25.1 nM
CCc1c(C#N)c(-c2ccc(-c3ccccc3SC)cc2)c(C(=O)O)n1C CHEMBL215090 EC50 32.0 nM
CCOc1ccccc1-c1ccc(-c2c(C#N)c(CC)n(C)c2C(=O)O)cc1 CHEMBL384271 EC50 36.0 nM
CCc1c(C#N)c(-c2ccc(-c3ccccc3Cl)cc2)c(C(=O)O)n1C CHEMBL384402 EC50 42.0 nM
Cc1cccc(Oc2ccc3c(c2)S(=O)(=O)NCN3C2CC2)c1 CHEMBL4062524 pEC50 46.13 nM
CCc1sc(C(=O)O)c(-c2ccc(C(C)(C)C)cc2)c1C#N CHEMBL214833 EC50 47.0 nM
Cc1sc2nc(Cn3nc(C(F)(F)F)cc3Cl)cc(=O)n2c1[C@@H]1C[C@H]1CO CHEMBL3800556 EC50 48.0 nM
N[C@@H](Cn1cc(Cl)c(=O)[nH]c1=O)C(=O)O CHEMBL121388 Ki 53.1 nM
CCc1c(C#N)c(-c2ccc(-c3ccccc3C#N)cc2)c(C(=O)O)n1C CHEMBL384847 EC50 73.0 nM
Cc1sc2nc(Cn3nc(C(F)(F)F)cc3Cl)cc(=O)n2c1[C@@H]1C[C@H]1C#N CHEMBL3799878 EC50 73.0 nM
CC(C)(C)c1ccc(-c2c(C(=O)O)sc(C(F)(F)F)c2C#N)cc1 CHEMBL214834 EC50 78.0 nM
CCn1nnc(-c2onc(O)c2CC(N)C(=O)O)n1 CHEMBL370941 Ki 80.2 nM
CSc1sc(C(=O)O)c(-c2ccc(C(C)(C)C)cc2)c1C#N CHEMBL213197 EC50 97.0 nM
CC(=O)c1cccc(-c2ccc([C@H]3COC[C@H]3NS(=O)(=O)C(C)C)cc2)c1 CHEMBL1289293 EC50 100.0 nM
CC(C)S(=O)(=O)N[C@H]1Cc2ccc(Cn3nc(C(F)(F)F)cc3C(F)(F)F)cc2C1 CHEMBL1642155 pEC50 100.0 nM
CC(C)S(=O)(=O)NC1CCc2cc(Cn3cc(CO)c(C(F)(F)F)n3)ccc21 CHEMBL1642168 pEC50 100.0 nM
N[C@@H](Cn1nc(I)c(=O)[nH]c1=O)C(=O)O CHEMBL121553 Ki 101.0 nM
N[C@@H](Cn1cc(Br)c(=O)[nH]c1=O)C(=O)O CHEMBL333964 Ki 101.0 nM
CCc1c(C#N)c(-c2ccc(-c3ccccc3)cc2)c(C(=O)O)n1C CHEMBL385608 EC50 103.0 nM
O=C(O)C1NCCc2c(O)noc21 CHEMBL154535 Ki 108.0 nM
CCc1c(C#N)c(-c2ccc(-c3ccccc3F)cc2)c(C(=O)O)n1C CHEMBL215575 EC50 111.0 nM
N[C@@H](Cn1cc([N+](=O)[O-])c(=O)[nH]c1=O)C(=O)O CHEMBL121191 Ki 115.0 nM
CCc1c(C#N)c(-c2ccc(-c3ccc(Cl)cc3)cc2)c(C(=O)O)n1C CHEMBL385652 EC50 142.0 nM
CC(CNS(=O)(=O)C(C)C)C1CCC(c2ccc(C#N)cc2)CC1 CHEMBL1097939 EC50 150.0 nM
CC(CNS(=O)(=O)C(C)C)c1ccc(-c2ccc(C#N)cc2)cc1 CHEMBL435582 EC50 150.0 nM
O=S(=O)(NC1CCc2cc(Cn3cc(CO)c(C(F)(F)F)n3)ccc21)C1CC1 CHEMBL1642169 pEC50 158.49 nM
CSc1c(C#N)c(-c2ccc(-c3ccccc3)cc2)c(C(=O)O)n1C CHEMBL385220 EC50 174.0 nM
N[C@@H](Cn1cc(I)c(=O)[nH]c1=O)C(=O)O CHEMBL121915 Ki 176.0 nM
CN(C)c1sc(C(=O)O)c(-c2ccc(C(C)(C)C)cc2)c1C#N CHEMBL218347 EC50 176.0 nM
CCc1c(C#N)c(-c2ccc(-c3cccc(Cl)c3)cc2)c(C(=O)O)n1C CHEMBL217074 EC50 186.0 nM
CCN(Cc1cc(=O)n2c([C@@H]3C[C@H]3CO)c(C)sc2n1)c1ccc(F)cc1 CHEMBL3799657 EC50 204.0 nM
NS(=O)(=O)c1cccc2c1c([N+](=O)[O-])cc1nc(O)c(O)nc12 CHEMBL222519 Ki 210.0 nM
Cc1cc([C@@H]2C[C@H]2C#N)n2c(=O)cc(Cn3nc(C(F)(F)F)cc3Cl)nc2c1 CHEMBL3976578 EC50 210.0 nM
N[C@H](Cc1nsnc1O)C(=O)O CHEMBL402444 Ki 234.0 nM
CCN(Cc1cc(=O)n2cc(C)sc2n1)c1ccc(F)cc1 CHEMBL3799732 EC50 245.0 nM
NC(Cc1onc(O)c1Br)C(=O)O CHEMBL73698 Ki 250.0 nM
CCc1c(C#N)c(-c2ccc(-c3ccccc3C)cc2)c(C(=O)O)n1C CHEMBL214903 EC50 270.0 nM
N[C@@H](Cc1nsnc1O)C(=O)O CHEMBL429594 Ki 273.0 nM
CCc1c(C#N)c(-c2ccc(-c3ccccc3OC)cc2)c(C(=O)O)n1C CHEMBL215013 EC50 280.0 nM
CC(C)S(=O)(=O)N[C@H]1CN(C)C[C@@H]1c1ccc(-c2cccc(NS(C)(=O)=O)c2)cc1 CHEMBL1289960 EC50 300.0 nM
CC(C)S(=O)(=O)N[C@@H]1COC[C@@H]1c1ccc(-c2ccc(F)nc2)cc1 CHEMBL1289294 EC50 300.0 nM
CC(C)S(=O)(=O)N[C@@H]1COC[C@@H]1c1ccc(-c2cncc(F)c2)cc1 CHEMBL1289408 EC50 300.0 nM
CC(C)S(=O)(=O)N[C@@H]1COC[C@@H]1c1ccc(-c2ccc(F)cn2)cc1 CHEMBL1289409 EC50 300.0 nM
CC(C)S(=O)(=O)N[C@@H]1COC[C@@H]1c1ccc(-c2cccs2)cc1 CHEMBL1289410 EC50 300.0 nM
Cc1c(C#N)c(-c2ccc(-c3ccccc3)cc2)c(C(=O)O)n1C CHEMBL215272 EC50 308.0 nM
CC(C)(C)c1ccc(-c2c(C(=O)O)sc(S(C)(=O)=O)c2C#N)cc1 CHEMBL217111 EC50 333.0 nM
CCc1c(C#N)c(-c2ccc(-c3ccc(F)cc3)cc2)c(C(=O)O)n1C CHEMBL214599 EC50 345.0 nM
O=S1(=O)NCN(C2CC2)c2ccc(F)cc21 CHEMBL2441067 Kd 350.0 nM
Cc1sc2nc(Cc3cccc(C(F)(F)F)c3F)cc(=O)n2c1C1CC1CO CHEMBL3800605 EC50 359.0 nM
NC(Cc1onc(O)c1Cl)C(=O)O CHEMBL72366 Ki 370.0 nM
CCc1c(C#N)c(-c2ccc(-c3ccc(C#N)cc3)cc2)c(C(=O)O)n1C CHEMBL384953 EC50 370.0 nM
CCc1c(C#N)c(-c2ccc(-c3ccc(OC)cc3)cc2)c(C(=O)O)n1C CHEMBL385384 EC50 370.0 nM
COc1cccc(Oc2ccc3c(c2)S(=O)(=O)NCN3C)c1 CHEMBL4060993 EC50 370.0 nM
Cc1nn(C[C@H](N)C(=O)O)c(=O)[nH]c1=O CHEMBL120808 Ki 372.0 nM
N#C[C@H]1C[C@H]1c1c(Cl)ccc2nc(Cn3nc(C(F)(F)F)cc3Cl)cc(=O)n12 CHEMBL5180445 IC50 380.0 nM
Cc1cccc(Oc2ccc3c(c2)S(=O)(=O)NCN3C)c1 CHEMBL4070694 EC50 390.0 nM
CCc1c(C#N)c(-c2ccc(-c3cccc(OC)c3)cc2)c(C(=O)O)n1C CHEMBL215255 EC50 391.0 nM
CCc1c(C#N)c(-c2ccc(-c3cccc(C#N)c3)cc2)c(C(=O)O)n1C CHEMBL214804 EC50 395.0 nM
CC(C)S(=O)(=O)NC1Cc2ccc(-c3cccc(CN4CCCS4(=O)=O)c3)cc2C1 CHEMBL1214335 pEC50 398.11 nM
CC(C)S(=O)(=O)NC[C@H](C)c1ccc(NC(=O)c2cc(F)cc(F)c2)cc1 CHEMBL1214201 pEC50 398.11 nM
NC(=O)c1c(NC(=O)Cn2cc(CO)c(C(F)(F)F)n2)sc2c1CCCC2 CHEMBL1642150 pEC50 398.11 nM
CC(C)S(=O)(=O)N[C@@H]1Cc2ccc(Cn3cc(CO)c(C(F)(F)F)n3)cc2C1 CHEMBL1642161 pEC50 398.11 nM
CCS(=O)(=O)N[C@H]1Cc2ccc(Cn3cc(CO)c(C(F)(F)F)n3)cc2C1 CHEMBL1642166 pEC50 398.11 nM
CC(C)S(=O)(=O)N[C@@H]1COC[C@@H]1c1ccc(-c2ccsc2)cc1 CHEMBL1289523 EC50 400.0 nM
O=C(O)[C@@H]1C[C@H]2C[C@@H](Oc3ccc(Cl)cc3-c3nnn[nH]3)CC[C@H]2CN1 CHEMBL3088060 Ki 400.0 nM
N#C[C@@H]1C[C@H]1c1cccc2nc(Cn3nc(C(F)(F)F)cc3Cl)cc(=O)n12 CHEMBL3891918 EC50 410.0 nM
CCc1c(C#N)c(-c2ccc(-c3ccc(C)cc3)cc2)c(C(=O)O)n1C CHEMBL214844 EC50 412.0 nM
CCc1c(C#N)c(-c2ccc(-c3cccc(F)c3)cc2)c(C(=O)O)n1C CHEMBL215574 EC50 426.0 nM
N#Cc1cccc(Oc2ccc3c(c2)S(=O)(=O)NCN3C2CC2)c1 CHEMBL4066717 EC50 450.0 nM
N#C[C@@H]1C[C@H]1c1c(F)ccc2nc(Cn3nc(C(F)(F)F)cc3Cl)cc(=O)n12 CHEMBL3970291 EC50 460.0 nM
N[C@@H](Cn1ncc(=O)[nH]c1=O)C(=O)O CHEMBL122656 Ki 461.0 nM
O=C(O)C1Cc2c(O)noc2CN1 CHEMBL2092841 Ki 494.0 nM
CC(C)S(=O)(=O)N[C@@H]1COC[C@@H]1c1ccc(-c2ccc(C#N)cc2)cc1 CHEMBL1289181 EC50 500.0 nM
CC(C)S(=O)(=O)N[C@H]1Cc2ccc(Cn3cc(CO)c(C(F)(F)F)n3)cc2C1 CHEMBL1232932 pEC50 501.19 nM
CS(=O)(=O)NC1CCc2cc(Cn3cc(CO)c(C(F)(F)F)n3)ccc21 CHEMBL1642170 pEC50 501.19 nM
CC(CNS(=O)(=O)C(C)C)c1ccc(NC(=O)c2ccccc2)cc1 CHEMBL105076 EC50 520.0 nM
CC(C)S(=O)(=O)N[C@@H]1CCC[C@@H]1c1ccc(Br)cc1 CHEMBL63417 EC50 520.0 nM
CCN(Cc1cc(=O)n2c(CCO)c(C)sc2n1)c1ccc(F)cc1 CHEMBL3797925 EC50 572.0 nM
CCN(Cc1cc2c(=O)n(CCC#N)ccc2s1)c1ccc(F)cc1 CHEMBL5197314 IC50 610.0 nM
CCN(Cc1cc2cc(C)n(CCC#N)c(=O)c2s1)c1ccc(F)cc1 CHEMBL5199303 IC50 610.0 nM
CSc1c(C#N)c(-c2ccc(C(C)(C)C)cc2)c(C(=O)O)n1C CHEMBL384010 EC50 663.0 nM
O=C(O)[C@@H]1C[C@H]2C[C@@H](CCc3nn[nH]n3)CC[C@H]2CN1 CHEMBL14935 Kb 700.0 nM
O=S1(=O)NCN(C2CC2)c2ccc(Oc3ccccc3)cc21 CHEMBL4100668 EC50 710.0 nM
CCN(Cc1ccn(CC2CC2)c(=O)c1)c1ccc(F)cc1 CHEMBL5270224 IC50 750.0 nM
CC(C)S(=O)(=O)NC1Cc2ccc(-c3cccc(NS(C)(=O)=O)c3)cc2C1 CHEMBL1214202 pEC50 794.33 nM
CCNCc1cn(CC(=O)Nc2sc3c(c2C(N)=O)CCCC3)nc1C(F)(F)F CHEMBL1234887 pEC50 794.33 nM
CC(C)S(=O)(=O)N[C@H]1Cc2ccc(Cn3cc(CO)c(C(F)(F)F)c3)cc2C1 CHEMBL1642160 pEC50 794.33 nM
CCN(Cc1cc(=O)n2nc(C)sc2n1)c1ccc(F)cc1 CHEMBL3800532 EC50 830.0 nM
N#C[C@H]1C[C@H]1c1c(C(F)(F)F)sc2nc(Cn3nc(C(F)(F)F)cc3Cl)cc(=O)n12 CHEMBL5171984 IC50 880.0 nM
N[C@@H](Cn1ccc(=O)[nH]c1=O)C(=O)O CHEMBL122005 Ki 898.0 nM
N[C@@H](CCC(=O)O)C(=O)O CHEMBL575060 Ki 940.0 nM
Cc1ccc(Oc2ccc3c(c2)S(=O)(=O)NCN3C)cc1 CHEMBL4083809 EC50 950.0 nM
CCc1c(C#N)c(-c2ccc(-c3cccc(C)c3)cc2)c(C(=O)O)n1C CHEMBL215877 EC50 965.0 nM
CCN(Cc1cc(=O)n2c(-c3cncnc3)c(C)sc2n1)c1ccc(F)cc1 CHEMBL3800085 EC50 972.0 nM
[N-]=[N+]=Nc1cc2[nH]c(=O)c(=O)[nH]c2cc1[N+](=O)[O-] CHEMBL506543 IC50 1000.0 nM
CC(C)S(=O)(=O)N[C@H]1Cc2ccc(Cc3ccc(C(F)(F)F)o3)cc2C1 CHEMBL1230591 pEC50 1000.0 nM
CN(C)S(=O)(=O)N[C@@H]1Cc2ccc(Cn3cc(CO)c(C(F)(F)F)n3)cc2C1 CHEMBL1642165 pEC50 1000.0 nM
O=C1CCCN1Cc1ccc(-n2nc(C(F)(F)F)c3c2CCCC3)cc1F CHEMBL1649674 pEC50 1000.0 nM
O=C1CCCN1Cc1ccc(-n2nc(C(F)(F)F)c3c2CCCC3)cc1 CHEMBL1649670 pEC50 1000.0 nM