CO[C@H]1CC[C@@H](C(=O)c2ccc3nc4c(cc3c2)CCCO4)CC1 CHEMBL174588 Ki 0.34 nM
O=c1c2sc3ncc4cc[nH]c4c3c2ncn1-c1ccc(Cl)cc1 CHEMBL238077 IC50 0.4 nM
CCCN1Cc2cc(-c3nnn(-c4cccnc4[18F])c3C)ccc2C1=O CHEMBL1645349 Ki 0.4 nM
CN(C)c1ccnc2sc3c(=O)n(-c4ccc(Cl)cc4)ccc3c12 CHEMBL1951661 IC50 0.4 nM
CO[C@H]1CC[C@@H](C(=O)c2ccc3nc4c(cc3c2)CCC4)CC1 CHEMBL178690 IC50 0.56 nM
Cc1ccc(-n2cnc3c(sc4ncc5cc[nH]c5c43)c2=O)cc1 CHEMBL393705 IC50 0.7 nM
CNc1ccnc2sc3c(=O)n(-c4ccc(Br)cc4)ccc3c12 CHEMBL1951872 IC50 0.8 nM
CCc1cc2cc(C(=O)[C@H]3CC[C@@H](OC)CC3)ccc2nc1[11CH3] CHEMBL1645348 Ki 0.87 nM
C#CCNc1ccnc2sc3c(=O)n(-c4ccc(Cl)cc4)cnc3c12 CHEMBL1783874 IC50 0.9 nM
CCc1cc2cc(C(=O)[C@H]3CC[C@@H](OC)CC3)ccc2nc1N CHEMBL2112967 IC50 1.0 nM
CN(C)c1ccnc2sc3c(=O)n(C4CCCCCC4)cnc3c12 CHEMBL225032 IC50 1.0 nM
CN(C)c1ncnc2sc3c(=O)n(-c4ccc(Br)cc4)cnc3c12 CHEMBL2205923 IC50 1.0 nM
CN(C)c1ncnc2sc3c(=O)n(-c4ccc(Cl)cc4)cnc3c12 CHEMBL2205922 IC50 1.0 nM
Cc1ccc(-n2cnc3c(sc4ncnc(N(C)C)c43)c2=O)cc1 CHEMBL2205921 IC50 1.0 nM
C=CCN(C)c1ccnc2sc3c(=O)n(-c4ccc(Cl)cc4)cnc3c12 CHEMBL1783864 IC50 1.1 nM
C[C@@H]1CNc2c(cnc3sc4c(=O)n(-c5ccc(Cl)cc5)cnc4c23)O1 CHEMBL241327 IC50 1.4 nM
C#CCNc1ccnc2sc3c(=O)n(-c4ccc(C)cc4)cnc3c12 CHEMBL1783875 IC50 1.5 nM
CNc1cc(-c2csc(N(C)C(=O)c3ccc(F)cc3)n2)ncn1 CHEMBL569270 IC50 1.8 nM
C#CCNc1ccnc2sc3c(=O)n(-c4ccc(Br)cc4)cnc3c12 CHEMBL1784049 IC50 1.8 nM
C#CCN(C)c1ccnc2sc3c(=O)n(-c4ccc(Br)cc4)cnc3c12 CHEMBL1784053 IC50 1.9 nM
CO[C@H]1CC[C@@H](C(=O)c2ccc3nc4c(cc3c2)CCS4)CC1 CHEMBL175463 IC50 2.0 nM
Cc1c(C2=CCN(C(=O)N(C)C(C)C)CC2)nnn1-c1cccnc1[18F] CHEMBL1645350 Ki 2.0 nM
C=CCNc1ccnc2sc3c(=O)n(-c4ccc(OC)cc4)cnc3c12 CHEMBL1783858 IC50 2.0 nM
CNc1ccnc2sc3c(=O)n(-c4ccc(Cl)cc4)ccc3c12 CHEMBL1951690 IC50 2.0 nM
CCNc1ccnc2sc3c(=O)n(-c4ccc(Br)cc4)ccc3c12 CHEMBL1951881 IC50 2.0 nM
COc1ccc(-n2cnc3c(sc4ncnc(N(C)C)c43)c2=O)cc1 CHEMBL2205920 IC50 2.0 nM
Cc1ccc(-n2cnc3c(sc4nc(N)nc(N)c43)c2=O)cc1 CHEMBL1093560 IC50 2.1 nM
C#CCNc1ccnc2sc3c(=O)n(-c4ccc(OC)cc4)cnc3c12 CHEMBL1783876 IC50 2.1 nM
C[C@H]1CNc2c(cnc3sc4c(=O)n(-c5ccc(Cl)cc5)cnc4c23)O1 CHEMBL236180 IC50 2.2 nM
Cc1ccc(-n2cnc3c(sc4ncc5c(c43)NCCO5)c2=O)cc1 CHEMBL235975 IC50 2.2 nM
O=c1c2sc3nccc(NC4CC4)c3c2ccn1-c1ccc(Br)cc1 CHEMBL1951882 IC50 2.3 nM
COc1ccc(-n2cnc3c(sc4ncc5c(c43)NC[C@@H](C)O5)c2=O)cc1 CHEMBL236177 IC50 2.4 nM
CN(C(=O)c1ccc(F)cc1)c1nc(-c2cc(N)ncn2)cs1 CHEMBL577729 IC50 2.4 nM
COc1ccc(-n2cnc3c(sc4ncc5c(c43)NCCO5)c2=O)cc1 CHEMBL393922 IC50 2.5 nM
CC(C)(C)OC(=O)N1CC=C(c2cn(-c3ncccc3F)nn2)CC1 CHEMBL452618 IC50 2.6 nM
Cc1c(-c2ccc3c(c2)CC(C2CC2)C3=O)nnn1-c1cccnc1 CHEMBL565943 IC50 2.6 nM
O=c1c2sc3ncc4c(c3c2ncn1-c1ccc(Cl)cc1)NCCO4 CHEMBL236994 IC50 2.9 nM
CCCc1ccc2cc(C(=O)[C@H]3CC[C@@H](OC)CC3)ccc2n1 CHEMBL176279 IC50 3.0 nM
CCc1ccc(-n2cnc3c(sc4nccc(N(C)C)c43)c2=O)cc1 CHEMBL385336 IC50 3.0 nM
OCCOCCNc1cc2c(NC3Cc4ccccc4C3)ncnc2cn1 CHEMBL469382 IC50 3.0 nM
C#CCNc1ncnc2sc3c(=O)n(-c4ccc(Cl)cc4)cnc3c12 CHEMBL1784067 IC50 3.0 nM
CCNc1ccnc2sc3c(=O)n(-c4ccc(Cl)cc4)ccc3c12 CHEMBL1951879 IC50 3.0 nM
O=c1c2sc3ncnc(NC4CC4)c3c2ncn1-c1ccc(Cl)cc1 CHEMBL2205371 IC50 3.0 nM
CCN(C)c1ncnc2sc3c(=O)n(-c4ccc(OC)cc4)cnc3c12 CHEMBL2205909 IC50 3.0 nM
Cc1ccc(-n2cnc3c(sc4nc(S)nc(N)c43)c2=O)cc1 CHEMBL1093869 IC50 3.1 nM
CN(C)c1ccnc2sc3c(=O)n(-c4ccc5ncsc5c4)ccc3c12 CHEMBL1951669 IC50 3.1 nM
CCN1Cc2cc(-c3nnn(-c4cccnc4F)c3C)ccc2C1=O CHEMBL577833 IC50 3.3 nM
CNc1ccnc2sc3c(=O)n(-c4ccc(C)cc4)ccc3c12 CHEMBL1951688 IC50 3.4 nM
Cc1c(-c2ccc3c(c2)CN(C2CC2)C3=O)nnn1-c1cccnc1F CHEMBL578995 IC50 3.5 nM
CCCN1Cc2cc(-c3nnn(-c4cccnc4F)c3C)ccc2C1=O CHEMBL568443 IC50 3.6 nM
Cc1c(-c2ccc3ncccc3c2)nnn1-c1cccnc1F CHEMBL1645352 IC50 3.6 nM
CCNc1cc(-c2csc(N(C)C(=O)c3ccc(F)cc3)n2)ncn1 CHEMBL566374 IC50 3.7 nM
C#CCN(C)c1ccnc2sc3c(=O)n(-c4ccc(Cl)cc4)cnc3c12 CHEMBL1784051 IC50 3.8 nM
C#CCNc1ncnc2sc3c(=O)n(-c4ccc(C)cc4)cnc3c12 CHEMBL1784068 IC50 3.9 nM
COc1ccc(-n2ccc3c(sc4nccc(N(C)C)c43)c2=O)cc1F CHEMBL1951666 IC50 3.9 nM
CCCOC(=O)c1[nH]cc(C(=O)O[C@@H](C)C(C)(C)C)c1C CHEMBL234972 Log IC50 3.981 nM
CCc1cc2cc(C(=O)C3CCC(OC)CC3)ccc2nc1Cl CHEMBL178592 IC50 4.0 nM
CN(C)c1ccnc2sc3c(=O)n(-c4ccc(Br)cc4)cnc3c12 CHEMBL225590 IC50 4.0 nM
CN(C)c1ncnc2sc3c(=O)n(-c4ccc(F)cc4)cnc3c12 CHEMBL2205924 IC50 4.0 nM
C=CCNc1ccnc2sc3c(=O)n(-c4ccc(F)cc4)cnc3c12 CHEMBL1783863 IC50 4.4 nM
O=c1c2sc3nccc(NC4CC4)c3c2ccn1-c1ccc(Cl)cc1 CHEMBL1951880 IC50 4.4 nM
C=C(C)CNc1ncnc2sc3c(=O)n(-c4ccccc4)cnc3c12 CHEMBL1784059 IC50 4.6 nM
Cc1ccc(-n2ccc3c(sc4nccc(N(C)C)c43)c2=O)cc1 CHEMBL1951659 IC50 4.7 nM
COCCN([11CH3])Cc1ccc2nc3sc(C(=O)N(C)C4CCCCC4)cn3c2c1 CHEMBL1645351 Ki 4.8 nM
COCCN(C)Cc1ccc2nc3sc(C(=O)N([11CH3])C4CCCCC4)cn3c2c1 CHEMBL1771388 Ki 4.8 nM
COc1ccc(-n2cnc3c(sc4ncc5cc[nH]c5c43)c2=O)cc1 CHEMBL238079 IC50 4.9 nM
Cc1c(-c2ccc3ncccc3c2)nnn1-c1cccnc1 CHEMBL583590 IC50 4.9 nM
Cc1ccc(-n2cnc3c(sc4nccc(N(C)C)c43)c2=O)cc1 CHEMBL223496 IC50 5.0 nM
CN(C)c1ccnc2sc3c(=O)n(C4CCCC4)cnc3c12 CHEMBL224617 IC50 5.0 nM
CN(C)c1ccnc2sc3c(=O)n(-c4ccc5scnc5c4)ccc3c12 CHEMBL1951668 IC50 5.0 nM
COc1ccc(-n2cnc3c(sc4ncnc(N(C)C5CC5)c43)c2=O)cc1 CHEMBL2205917 IC50 5.0 nM
CNc1ncnc2sc3c(=O)n(-c4ccc(OC)cc4)cnc3c12 CHEMBL2205378 IC50 5.0 nM
COc1ccc(-n2cnc3c(sc4ncnc(N(C)C)c43)c2=O)cc1F CHEMBL2203308 IC50 5.0 nM
CC(C)Nc1cc(-c2csc(N(C)C(=O)c3ccc(F)cc3)n2)ncn1 CHEMBL566581 IC50 5.1 nM
CN(C)c1ccnc2sc3c(=O)n(-c4ccc(F)cc4)ccc3c12 CHEMBL1951660 IC50 5.2 nM
Cc1ccc(-n2cnc3c(sc4ncc5c(c43)NC[C@@H](C)O5)c2=O)cc1 CHEMBL235977 IC50 5.3 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(Cl)cc3C2=O)cc1F CHEMBL3759901 pEC50 5.37 nM
COc1ccnc2sc3c(=O)n(C4CCCCC4)ccc3c12 CHEMBL1951677 IC50 5.4 nM
Cc1c(-c2ccc3c(c2)CN(C(C)C)C3=O)nnn1-c1cccnc1F CHEMBL584478 IC50 5.5 nM
Cc1c(C2=CCN(C(=O)N(C)C(C)C)CC2)nnn1-c1cccnc1F CHEMBL502882 IC50 5.6 nM
CN(C)c1ccnc2sc3c(=O)n(-c4ccc(Br)cc4)ccc3c12 CHEMBL1951662 IC50 5.7 nM
CNc1c(Br)cnc2sc3c(=O)n(-c4ccc(Cl)cc4)cnc3c12 CHEMBL241547 IC50 5.9 nM
CCCc1cc2cc(C(=O)[C@H]3CC[C@@H](OC)CC3)ccc2nc1C CHEMBL360728 IC50 6.0 nM
O=c1c2sc3ncc4nc[nH]c4c3c2ncn1-c1ccc(Cl)cc1 CHEMBL394914 IC50 6.0 nM
Cc1c(C2=CCC(C(=O)N(C)C(C)C)CC2)nnn1-c1cccnc1F CHEMBL254573 IC50 6.0 nM
CN(C(=O)c1ccc(F)cc1)c1nc(-c2ccccn2)cs1 CHEMBL572135 IC50 6.0 nM
COc1ccc(-n2cnc3c(sc4ncnc(NC5CC5)c43)c2=O)cc1 CHEMBL2205915 IC50 6.0 nM
CC(C)(C)OC(=O)N1CC=C(c2cn(-c3ccccc3F)nn2)CC1 CHEMBL461673 IC50 6.3 nM
COc1ccc(-n2ccc3c(sc4nccc(N(C)C)c43)c2=O)cc1 CHEMBL1951658 IC50 6.3 nM
COc1ccc(-n2ccc3c(sc4nccc(OC)c43)c2=O)cc1 CHEMBL1951670 IC50 6.3 nM
COc1ccc(-n2ccc3c(sc4ncnc(N(C)C)c43)c2=O)cc1 CHEMBL1951883 IC50 6.4 nM
CN1CC(=O)N=C1NC(=O)Nc1cccc(Cl)c1 CHEMBL239800 Ki 6.7 nM
Cc1ccc(-n2ccc3c(sc4ncnc(N(C)C)c43)c2=O)cc1 CHEMBL1951887 IC50 6.7 nM
C#CCNc1ncnc2sc3c(=O)n(-c4ccc(Br)cc4)cnc3c12 CHEMBL1784070 IC50 6.8 nM
C=CCNc1ccnc2sc3c(=O)n(-c4ccc(F)c(OC)c4)cnc3c12 CHEMBL1783862 IC50 6.8 nM
C=CCN(C)c1ccnc2sc3c(=O)n(-c4ccc(OC)cc4)cnc3c12 CHEMBL1783865 IC50 6.9 nM
CCc1cc2cc(C(=O)C3COc4ccccc4O3)ccc2nc1C CHEMBL177519 IC50 7.0 nM
Cc1c(C2=CCN(C(=O)OC(C)(C)C)CC2)nnn1-c1ncccc1F CHEMBL456823 IC50 7.0 nM
COc1ccc(-c2nsc(NC(=O)[C@@H]3C[C@H]3C)c2C)cc1F CHEMBL2011874 IC50 7.0 nM
Cc1c(-c2ccc(Br)cc2)nsc1NC(=O)[C@@H]1C[C@H]1C CHEMBL2011877 IC50 7.0 nM
CCNc1ncnc2sc3c(=O)n(-c4ccc(OC)cc4)cnc3c12 CHEMBL2205908 IC50 7.0 nM
COc1ccc(-n2cnc3c(sc4ncnc(N(C)C)c43)c2=O)c(F)c1 CHEMBL2205377 IC50 7.0 nM
CN(C)c1ncnc2sc3c(=O)n(C4CCCCC4)cnc3c12 CHEMBL2205928 IC50 7.0 nM
Cc1c(C2=CCN(C(=O)OC(C)C)CC2)nnn1-c1cccnc1F CHEMBL456196 IC50 7.2 nM
C=C(C)CNc1ncnc2sc3c(=O)n(-c4ccc(Cl)cc4)cnc3c12 CHEMBL1784054 IC50 7.7 nM
CCNc1ccnc2sc3c(=O)n(-c4ccc(C)cc4)ccc3c12 CHEMBL1951877 IC50 7.7 nM
CCc1cc2cc(C(=O)C3CCC(OC)CC3)ccc2nc1CC CHEMBL175377 IC50 8.0 nM
CSc1ccc(-n2cnc3c(sc4ncnc(N(C)C)c43)c2=O)cc1 CHEMBL2205927 IC50 8.0 nM
O=C1CN=C(c2cccs2)C=C2c3cccc(Br)c3CCN12 CHEMBL3702381 IC50 8.0 nM
CN(C)c1ccnc2sc3c(=O)n(C4CCCCC4)ccc3c12 CHEMBL1951665 IC50 8.1 nM
C#CCNc1ncnc2sc3c(=O)n(-c4ccc(F)cc4)cnc3c12 CHEMBL1784072 IC50 8.2 nM
CCc1ccc(-n2ccc3c(sc4nccc(N(C)C)c43)c2=O)cc1 CHEMBL1951664 IC50 8.2 nM
C=C(C)CNc1ncnc2sc3c(=O)n(-c4ccc5sccc5c4)cnc3c12 CHEMBL1784065 IC50 8.9 nM
CCc1cc2cc(C(=O)[C@H]3CC[C@@H](OC)CC3)ccc2nc1F CHEMBL2112964 IC50 9.0 nM
CCc1cccc(-n2cnc3c(sc4nccc(N(C)C)c43)c2=O)c1 CHEMBL224084 IC50 9.0 nM
COc1ccc(-c2nsc(NC(=O)[C@@H]3C[C@H]3C)c2C)cc1 CHEMBL2011870 IC50 9.0 nM
Cc1c(-c2ccc(Cl)cc2)nsc1NC(=O)[C@@H]1C[C@H]1C CHEMBL2011876 IC50 9.0 nM
Cc1ccc(-n2cnc3c(sc4ncnc(NC5CC5)c43)c2=O)cc1 CHEMBL2205370 IC50 9.0 nM
COc1ccc(-n2cnc3c(sc4ncnc(NCCCCO)c43)c2=O)cc1 CHEMBL2205914 IC50 9.0 nM
COc1ccc(-n2cnc3c(sc4nccc(N(C)C)c43)c2=O)cc1 CHEMBL428909 IC50 9.5 nM
C=C(C)CNc1ncnc2sc3c(=O)n(-c4ccc(OC)cc4)cnc3c12 CHEMBL1784056 IC50 9.6 nM
Cn1cnc2cnc3sc4c(=O)n(-c5ccc(Cl)cc5)cnc4c3c21 CHEMBL238090 IC50 9.8 nM
CC(C)(C)OC(=O)N1CC=C(c2cn(-c3ccccc3)nn2)CC1 CHEMBL511355 IC50 9.8 nM
Cc1ccc(-n2ccc3c(sc4nccc(NC5CC5)c43)c2=O)cc1 CHEMBL1951878 IC50 9.8 nM
CN(C)c1ccnc2sc3c(=O)n(N4CCCCCC4)cnc3c12 CHEMBL386565 IC50 10.0 nM
CN(C(=O)c1ccc(F)cc1)c1nc(-c2ccncn2)cs1 CHEMBL568991 IC50 10.0 nM
CN(C)c1ccnc2sc3c(=O)n(-c4ccc(C#N)cc4)ccc3c12 CHEMBL1951663 IC50 10.0 nM
C=C(C)CNc1ccnc2sc3c(=O)n(-c4ccc(OC)cc4)cnc3c12 CHEMBL1783869 IC50 10.4 nM
C=C(C)CNc1ccnc2sc3c(=O)n(-c4ccc(Cl)cc4)cnc3c12 CHEMBL1783867 IC50 10.6 nM
C=C(C)CNc1ncnc2sc3c(=O)n(-c4ccc(F)cc4)cnc3c12 CHEMBL1784061 IC50 10.7 nM
C#CCN(C)c1ccnc2sc3c(=O)n(-c4ccc(OC)cc4)cnc3c12 CHEMBL1784052 IC50 10.8 nM
Cc1ccccc1-n1cc(C2=CCN(C(=O)OC(C)(C)C)CC2)nn1 CHEMBL511352 IC50 11.0 nM
Cc1c(-c2ccc3c(c2)CC(C)(C)C3=O)nnn1-c1cccnc1 CHEMBL568451 IC50 11.0 nM
Cc1nc(N)c2c(n1)sc1c(=O)n(-c3ccc(Cl)cc3)cnc12 CHEMBL1092277 IC50 11.0 nM
NCCCNCCCCNCCCNC(=O)[C@H](CC1CCCCC1)NC(=O)C1CC1 CHEMBL1270718 IC50 11.0 nM
C=CCNc1ccnc2sc3c(=O)n(-c4ccc(C)cc4)cnc3c12 CHEMBL1783859 IC50 11.0 nM
Cc1ccc2c(c1)C(=O)N(c1ccc(NC(=O)c3occc3C)c(F)c1)C2=O CHEMBL3758746 pEC50 11.48 nM
C[C@H]1COc2cnc3sc4c(=O)n(-c5ccc(Cl)cc5)cnc4c3c2N1 CHEMBL393923 IC50 12.0 nM
COc1ccc(-n2ccc3c(sc4nccc(NC5CC5)c43)c2=O)cc1 CHEMBL1951683 IC50 12.0 nM
Cc1ccc(-n2ccc3c(sc4ncnc(NC5CC5)c43)c2=O)cc1 CHEMBL1951890 IC50 12.0 nM
COc1ccc(-n2cnc3c(sc4ncnc(NCCCO)c43)c2=O)cc1 CHEMBL2205913 IC50 12.0 nM
C=C(C)CNc1ncnc2sc3c(=O)n(-c4ccc(C)cc4)cnc3c12 CHEMBL1784055 IC50 12.4 nM
C#CCNc1ccnc2sc3c(=O)n(-c4ccc(OC)c(F)c4)cnc3c12 CHEMBL1784050 IC50 12.5 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)cc1F CHEMBL3634445 pIC50 12.59 nM
C=CCNc1ccnc2sc3c(=O)n(-c4ccc(Br)cc4)cnc3c12 CHEMBL1783861 IC50 12.6 nM
CN(C)c1ccnc2sc3c(=O)n(C4CCCCCCC4)cnc3c12 CHEMBL223399 IC50 13.0 nM
C#CCNc1ncnc2sc3c(=O)n(-c4ccc(OC)cc4)cnc3c12 CHEMBL1784069 IC50 13.0 nM
O=C(Cc1ccccc1)c1ccc2nc3c(cc2c1)CCCO3 CHEMBL369459 IC50 14.0 nM
COc1ccc(-n2ccc3c(sc4nccc(N(C)C)c43)c2=O)c(F)c1 CHEMBL1951667 IC50 14.0 nM
CN(C)c1ncnc2sc3c(=O)n(-c4ccc(OC(F)(F)F)cc4)cnc3c12 CHEMBL2205925 IC50 14.0 nM
C=C(C)CNc1ncnc2sc3c(=O)n(-c4ccc(Br)cc4)cnc3c12 CHEMBL1784057 IC50 14.5 nM
CCNc1ccnc2sc3c(=O)n(-c4ccc(OC)cc4)ccc3c12 CHEMBL1951681 IC50 15.0 nM
COc1ccc(-n2ccc3c(sc4ncnc(NC5CC5)c43)c2=O)cc1 CHEMBL1951886 IC50 15.0 nM
CCNc1ncnc2sc3c(=O)n(-c4ccc(C)cc4)ccc3c12 CHEMBL1951889 IC50 15.0 nM
COc1ccc(-n2cnc3c(sc4ncnc(N(C)C)c43)c2=O)c(C)c1 CHEMBL2205376 IC50 15.0 nM
Cc1cc(N2C(=O)c3ccccc3C2=O)ccc1NC(=O)c1occc1C CHEMBL3634447 EC50 15.0 nM
COc1cccc2c1CCN1C(=O)CN=C(c3cccs3)C=C21 CHEMBL3702360 IC50 15.0 nM
CC(C)n1cc(C2=NCC(=O)N3CCc4c(I)cccc4C3=C2)cn1 CHEMBL3702386 IC50 15.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)c2ccccc12 CHEMBL3634442 pIC50 15.85 nM
C[C@H]1CC[C@@H](C(=O)c2ccc3nc4c(cc3c2)CCCCC4)CC1 CHEMBL2112048 IC50 16.0 nM
CN(C)c1ccnc2sc3c(=O)n(-c4ccc(Cl)cc4)cnc3c12 CHEMBL225589 IC50 16.0 nM
Cc1c(C(=O)NC2CCCCC2)sc2nc3ccc(N)cc3n12 CHEMBL254777 IC50 16.0 nM
CC(C)(C)OC(=O)N1CC=C(c2cn(-c3ccc(F)cc3)nn2)CC1 CHEMBL460827 IC50 16.0 nM
Cc1nc(N)c2c(n1)sc1c(=O)n(-c3ccccc3)cnc12 CHEMBL1090247 IC50 16.0 nM
C=C(C)CNc1ncnc2sc3c(=O)n(-c4ccc5scnc5c4)cnc3c12 CHEMBL1784063 IC50 16.0 nM
CN(C)c1ncnc2sc3c(=O)n(-c4ccc(C(F)(F)F)cc4)cnc3c12 CHEMBL2205926 IC50 16.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)cc1 CHEMBL3634415 EC50 16.0 nM
C=C(C)CNc1ccnc2sc3c(=O)n(-c4ccc(C)cc4)cnc3c12 CHEMBL1783868 IC50 16.4 nM
Cc1ccc(-n2cnc3c(sc4ncc5cn[nH]c5c43)c2=O)cc1 CHEMBL238262 IC50 16.8 nM
Cc1ccc(-n2cnc3c(sc4nccc(N(C)C)c43)c2=O)c(C)c1 CHEMBL224356 IC50 17.0 nM
C=C(C)CNc1ncnc2sc3c(=O)n(-c4ccc5ncsc5c4)cnc3c12 CHEMBL1784064 IC50 17.0 nM
COc1ccc(-n2ccc3c(sc4nccc(N(C)CCO)c43)c2=O)cc1 CHEMBL1951687 IC50 17.0 nM
CO[C@H]1CC[C@@H](C(=O)c2ccc3nc4c(cc3c2)CCCCC4)CC1 CHEMBL178741 IC50 18.0 nM
CC(C)(C)OC(=O)N1CC=C(c2cn(-c3cccc(F)c3)nn2)CC1 CHEMBL460391 IC50 18.0 nM
CCN(C(=O)c1ccc(F)cc1)c1nc(-c2ccccn2)cs1 CHEMBL567668 IC50 18.0 nM
COc1cc(NC(=O)c2occc2C)ccc1N1C(=O)c2cccc(Cl)c2C1=O CHEMBL3632642 EC50 18.0 nM
CN(C)c1ccnc2sc3c(=O)n(C4CCCCCC4)nnc3c12 CHEMBL374180 IC50 19.0 nM
COc1ccc(-n2cnc3c(sc4ncnc(NC5CC5)c43)c2=O)cc1F CHEMBL2205374 IC50 19.0 nM
CCCNc1ncnc2sc3c(=O)n(-c4ccc(OC)cc4)cnc3c12 CHEMBL2205910 IC50 19.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c2ccccc12 CHEMBL3634444 pIC50 19.5 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(F)cc3C2=O)cc1F CHEMBL3758435 pEC50 19.5 nM
CCOC(=O)c1[nH]cc(C(=O)OC2CC3CCC2C3)c1C CHEMBL396593 Log IC50 19.95 nM
CCc1cc2cc(C(=O)C3CCC(OC)CC3)ccc2nc1OC CHEMBL175643 IC50 20.0 nM
CN(C)c1ccnc2sc3c(=O)n(-c4ccccc4)cnc3c12 CHEMBL224615 IC50 20.0 nM
COc1ccc(-n2cnc3c(sc4ncnc(N(C)C)c43)c2=O)cn1 CHEMBL2205930 IC50 20.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c2ccccc12 CHEMBL3634441 EC50 20.0 nM
NCCCNCCCCNCCCNC(=O)[C@H](CC1CCCCC1)NC(=O)C1CCCCC1 CHEMBL1270719 IC50 21.0 nM
C#CCNc1ncnc2sc3c(=O)n(-c4ccc5occc5c4)cnc3c12 CHEMBL1784077 IC50 21.0 nM
Cc1cc(NC(=O)c2occc2C)ccc1N1C(=O)c2cccc(C)c2C1=O CHEMBL3634423 EC50 21.0 nM
Cc1ccc2c(c1)C(=O)N(c1ccc(NC(=O)c3ncsc3C)cc1Cl)C2=O CHEMBL3759038 pEC50 21.88 nM
Cc1c(-c2ccc(C(=O)C3CC3)cc2)nnn1-c1cccnc1 CHEMBL568648 IC50 22.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(F)c1 CHEMBL3634418 EC50 22.0 nM
C#Cc1cccc2c1CCN1C(=O)CN=C(c3cccs3)C=C21 CHEMBL3702389 IC50 22.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)c2ccccc12 CHEMBL3634443 pIC50 22.39 nM
Cc1cn[nH]c1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1 CHEMBL3759028 pEC50 22.39 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)cc1F CHEMBL3758465 pEC50 22.39 nM
CN(C)c1ccnc2sc3c(=O)n(-c4ccc(F)cc4)cnc3c12 CHEMBL225124 IC50 23.0 nM
CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCNCCCCNCCCN CHEMBL16117 IC50 23.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(F)cc3C2=O)c(Cl)c1 CHEMBL3628114 pEC50 23.99 nM
COc1ccc(-n2cnc3c(sc4ncnc(NCC(F)(F)F)c43)c2=O)cc1 CHEMBL2205911 IC50 24.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)c(Cl)c1 CHEMBL3628109 EC50 24.3 nM
C[C@@H]1COc2cnc3sc4c(=O)n(-c5ccc(Cl)cc5)cnc4c3c2N1 CHEMBL236178 IC50 24.4 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)cc1F CHEMBL3758305 pEC50 25.7 nM
CN(C)c1ccnc2sc3c(=O)n(CC4CCCC4)cnc3c12 CHEMBL386935 IC50 26.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)c(F)c1 CHEMBL3634419 EC50 26.0 nM
Cc1ccc(-n2cnc3c(sc4nc(C)nc(N)c43)c2=O)cc1 CHEMBL1093901 IC50 27.0 nM
CNc1ccnc2sc3c(=O)n(-c4ccc(OC)cc4)ccc3c12 CHEMBL1951680 IC50 27.0 nM
O=C1CN=C(c2cccs2)C=C2c3cccc(Cl)c3CCN12 CHEMBL3702357 IC50 27.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)c(F)c1 CHEMBL3634420 pIC50 27.54 nM
OCCSc1nc2c(c(NC3Cc4ccccc4C3)n1)CCCC2 CHEMBL3786530 IC50 28.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)cc1 CHEMBL3634416 pIC50 28.84 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)cc1Cl CHEMBL3634446 pIC50 28.84 nM
CO[C@H]1CC[C@@H](C(=O)c2ccc3nc4c(cc3c2)CCCN4C)CC1 CHEMBL174216 IC50 29.0 nM
COc1ccc(-n2cnc3c(sc4ncnc(NC5CC5)c43)c2=O)c(F)c1 CHEMBL2205375 IC50 30.0 nM
O=c1c2scc(-c3ccccc3F)c2ncn1-c1ccc(Cl)cc1 CHEMBL3955218 IC50 30.0 nM
CNc1ncnc2sc3c(=O)n(-c4ccc(C)cc4)ccc3c12 CHEMBL1951888 IC50 31.0 nM
COCCNC(=O)c1[nH]cc(C(=O)O[C@@H](C)C(C)(C)C)c1C CHEMBL233708 Log IC50 31.62 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1 CHEMBL3628113 EC50 31.8 nM
CN(C)c1ccnc2sc3c(=O)n(-c4ccc(C(F)(F)F)cc4)cnc3c12 CHEMBL224375 IC50 32.0 nM
CCCC(=O)N[C@@H](CC1CCCCC1)C(=O)NCCCNCCCCNCCCN CHEMBL1270621 IC50 32.0 nM
Cc1c(-c2ccc(C(=O)OC(C)C)cc2)nnn1-c1cccnc1 CHEMBL568449 IC50 33.0 nM
C=C(C)CNc1ncnc2sc3c(=O)n(-c4ccc5c(c4)OCCO5)cnc3c12 CHEMBL1784066 IC50 33.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)c(Cl)c1 CHEMBL3628111 EC50 33.0 nM
CCNc1ncnc2sc3c(=O)n(-c4ccc(OC)cc4)ccc3c12 CHEMBL1951885 IC50 34.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(F)c1 CHEMBL3634421 pIC50 34.67 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)nc1 CHEMBL3634435 pIC50 34.67 nM
CCc1ccc(-n2ccc3c(sc4nccc(OC)c43)c2=O)cc1 CHEMBL1951675 IC50 35.0 nM
Cn1ccc(C2=NCC(=O)N3CCc4c(I)cccc4C3=C2)n1 CHEMBL3702383 IC50 35.0 nM
Cc1cccc(C#Cc2ccccc2)n1 CHEMBL66654 Ki 36.0 nM
CCc1ccc(-n2cnc3c(sc4nccc(N(C)CC)c43)c2=O)cc1 CHEMBL223543 IC50 37.0 nM
O=c1c2sc3ncc4cn[nH]c4c3c2ncn1-c1ccc(Cl)cc1 CHEMBL238263 IC50 37.6 nM
COc1ccc(-n2cnc3c(sc4nccc(N(C)C)c43)c2=O)cn1 CHEMBL389870 IC50 39.0 nM
CC(C)OC(=O)N1CC=C(c2cn(-c3cccnc3F)nn2)CC1 CHEMBL457026 IC50 39.0 nM
Cc1c(-c2ccc(Cl)c(Cl)c2)nsc1NC(=O)[C@@H]1C[C@H]1C CHEMBL2011878 IC50 39.0 nM
CCc1ccc(-n2cnc3c(sc4nccc(NC5CC5)c43)c2=O)cc1 CHEMBL224088 IC50 41.0 nM
NCCCNCCCCNCCCNC(=O)[C@H](CC1CCCCC1)NC(=O)Cc1cccc2ccccc12 CHEMBL1269126 IC50 41.0 nM
Cc1ccc2c(c1)C(=O)N(c1ccc(NC(=O)c3ncoc3C)cc1Cl)C2=O CHEMBL3758587 EC50 41.0 nM
O=C1CN=C(n2cnc(CCO)c2)C=C2c3cccc(C4CC4)c3CCN12 CHEMBL3644406 IC50 41.0 nM
Cc1ccoc1C(=O)Nc1c(F)cc(N2C(=O)c3ccccc3C2=O)c(F)c1F CHEMBL4799902 EC50 42.0 nM
Cc1ccc(-n2cnc3c(sc4cncc(N(C)C)c43)c2=O)cc1 CHEMBL223869 IC50 43.0 nM
C=C(C)CNc1ccnc2sc3c(=O)n(-c4ccc(Br)cc4)cnc3c12 CHEMBL1783870 IC50 43.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)cc1 CHEMBL3634417 pIC50 43.65 nM
CCc1ccc(-n2c(C)nc3c(sc4nccc(N(C)C)c43)c2=O)cc1 CHEMBL224673 IC50 44.0 nM
CN(C)c1ccnc2sc3c(=O)n(-c4ccc(Cl)cc4Cl)cnc3c12 CHEMBL224898 IC50 45.0 nM
C#CCNc1ncnc2sc3c(=O)n(-c4ccc5scnc5c4)cnc3c12 CHEMBL1784075 IC50 45.0 nM
COc1ccc(-n2cnc3c(-c4ccccc4C)csc3c2=O)cc1 CHEMBL3330823 IC50 45.0 nM
COc1cc(NC(=O)c2occc2C)ccc1N1C(=O)c2ccccc2C1=O CHEMBL3634430 EC50 46.0 nM
CNc1ccnc2sc3c(=O)n(-c4ccc5scnc5c4)ccc3c12 CHEMBL1951876 IC50 47.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)cc1 CHEMBL3634414 pIC50 47.86 nM
Cc1cc(NC(=O)c2occc2C)ccc1N1C(=O)c2cccc(Cl)c2C1=O CHEMBL3634424 pIC50 48.98 nM
Cc1cc(NC(=O)c2occc2C)ccc1N1C(=O)c2cccc(F)c2C1=O CHEMBL3634425 pIC50 48.98 nM
COc1cc(NC(=O)c2occc2C)ccc1N1C(=O)c2cccc(C)c2C1=O CHEMBL3634431 pIC50 48.98 nM
CCc1ccc(-n2cnc3c(sc4nccc(NCC#N)c43)c2=O)cc1 CHEMBL426190 IC50 49.0 nM
CC(C)(C)OC(=O)N1CC=C(c2cn(-c3ccccn3)nn2)CC1 CHEMBL457872 IC50 49.0 nM
CN(C(=O)c1ccc(F)cc1)c1nc(-c2ccncc2)cs1 CHEMBL578580 IC50 49.0 nM
CN(C(=O)c1ccc(F)cc1)c1nc(-c2cnccn2)cs1 CHEMBL568317 IC50 49.0 nM
CN(C)c1ccnc2sc3c(=O)n(-c4ccccc4O)cnc3c12 CHEMBL389897 IC50 50.0 nM
CN(C)c1ccnc2sc3c(=O)n(C4CCCCC4)cnc3c12 CHEMBL389655 IC50 50.0 nM
COc1ccc(-n2cnc3c(-c4ccccc4)csc3c2=O)cc1 CHEMBL3330811 IC50 50.0 nM
Cc1scnc1C(=O)Nc1ccc(N2C(=O)c3ccc(Cl)cc3C2=O)c(Cl)c1 CHEMBL3758216 pEC50 50.12 nM
CCc1cc2cc(C(=O)Cc3ccccc3)ccc2nc1C CHEMBL177586 IC50 51.0 nM
C=C(C)CNc1ncnc2sc3c(=O)n(-c4cccc(Cl)c4)cnc3c12 CHEMBL1784062 IC50 53.0 nM
COc1ccc(-n2ccc3c(sc4nccc(OC)c43)c2=O)c(C)c1 CHEMBL1951674 IC50 54.0 nM
Cc1ocnc1C(=O)Nc1ccc(N2C(=O)c3ccc(Cl)cc3C2=O)c(Cl)c1 CHEMBL3759289 EC50 54.0 nM
Cc1ccc2c(c1)C(=O)N(c1ccc(NC(=O)c3occc3C)cc1Cl)C2=O CHEMBL3628110 EC50 54.4 nM
CC(C)(C)OC(=O)N1CC=C(c2cn(-c3cccnc3)nn2)CC1 CHEMBL453249 IC50 55.0 nM
CCCNc1ccnc2sc3c(=O)n(-c4ccc(OC)cc4)ccc3c12 CHEMBL1951682 IC50 55.0 nM
Cc1scnc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(Cl)c1 CHEMBL3758683 EC50 56.0 nM
Cc1ccoc1C(=O)Nc1cc(F)c(N2C(=O)c3cccc(Cl)c3C2=O)c(F)c1F CHEMBL4787053 EC50 56.0 nM
CC(C)(C)NC(=O)N1CC=C(c2cn(-c3ccccc3F)nn2)CC1 CHEMBL461034 IC50 57.0 nM
COc1ccc(-n2cnc3c(-c4ccccc4F)csc3c2=O)cc1 CHEMBL3330817 IC50 57.0 nM
O=c1c2scc(-c3ccccc3)c2ncn1-c1cccc(F)c1 CHEMBL3330801 IC50 58.0 nM
O=c1c2scc(-c3ccccc3)c2ncn1-c1cccc(Cl)c1 CHEMBL3330804 IC50 58.0 nM
Cc1cc(N2C(=O)c3cccc(Cl)c3C2=O)c(F)cc1NC(=O)c1occc1C CHEMBL4798021 EC50 58.0 nM
Cc1cc(N2C(=O)C3=C(CCCC3)C2=O)c(F)cc1NC(=O)c1occc1C CHEMBL4792152 EC50 58.0 nM
C=CCNc1ccnc2sc3c(=O)n(-c4ccc(Cl)cc4)cnc3c12 CHEMBL1783860 IC50 60.0 nM
COc1ccc(-n2cnc3c(sc4ncnc(NC5CCC5)c43)c2=O)cc1 CHEMBL2205918 IC50 60.0 nM
CCc1cc2cc(C(=O)C3CCC(OC)CC3)ccc2nc1I CHEMBL177043 IC50 62.0 nM
CN(C(=O)c1ccc(Cl)cc1)c1nc(-c2ccncc2)cs1 CHEMBL577035 IC50 62.0 nM
Cc1scnc1C(=O)Nc1ccc(N2C(=O)c3ccc(F)cc3C2=O)c(Cl)c1 CHEMBL3758967 EC50 63.0 nM
Cc1ccoc1C(=O)Nc1cc(F)c(N2C(=O)c3cccc(F)c3C2=O)c(F)c1F CHEMBL4746530 EC50 63.0 nM
Cc1c(-c2ccccc2)nsc1NC(=O)[C@@H]1C[C@H]1C CHEMBL2011872 IC50 65.0 nM
C=CCN(C)c1ccnc2sc3c(=O)n(-c4ccc(Br)cc4)cnc3c12 CHEMBL1783866 IC50 66.0 nM
O=c1c2scc(-c3ccccc3)c2ncn1-c1ccc(F)cc1 CHEMBL3330802 IC50 66.0 nM
O=c1c2scc(-c3ccccc3)c2ncn1-c1ccc(Cl)cc1 CHEMBL3330805 IC50 66.0 nM
Cc1c(-c2ccc(C(C)(F)F)cc2)nsc1NC(=O)[C@@H]1C[C@H]1C CHEMBL2011879 IC50 67.0 nM
Cc1nc(N)c2c(n1)sc1c(=O)n(-c3ccc(F)cc3)cnc12 CHEMBL1092276 IC50 68.0 nM
CNc1ccnc2sc3c(=O)n(-c4ccc(F)cc4)ccc3c12 CHEMBL1951689 IC50 68.0 nM
Cc1c(-c2ccc3c(c2)CCC3=O)nnn1-c1cccnc1 CHEMBL577943 IC50 69.0 nM
O=c1c2sc3ncnc(NC4CC4)c3c2ncn1C1CCCCC1 CHEMBL2205373 IC50 70.0 nM
CCc1ccc(-n2cnc3c(sc4nccc(N(C)CCOC)c43)c2=O)cc1 CHEMBL225125 IC50 71.0 nM
C=C(C)CNc1ncnc2sc3c(=O)n(-c4ccc(OC)c(F)c4)cnc3c12 CHEMBL1784058 IC50 72.0 nM
O=C(Cc1ccsc1)c1ccc2nc3c(cc2c1)CCCO3 CHEMBL178742 IC50 74.0 nM
C=Cc1cccc(-n2cnc3c(-c4ccccc4)csc3c2=O)c1 CHEMBL3330812 IC50 74.0 nM
Cc1cc(NC(=O)c2occc2C)c(F)cc1N1C(=O)c2ccccc2C1=O CHEMBL4745982 EC50 74.0 nM
CNc1ccnc2sc3c(=O)n(-c4ccc(OC)c(F)c4)ccc3c12 CHEMBL1951874 IC50 75.0 nM
CN(C)c1ccnc2sc3c(=O)n(C45CC6CC(CC(C6)C4)C5)cnc3c12 CHEMBL224322 IC50 76.0 nM
CC(C)N(C)c1cc(-c2csc(N(C)C(=O)c3ccc(F)cc3)n2)ncn1 CHEMBL584066 IC50 77.0 nM
Cc1cc(N2C(=O)c3cccc(F)c3C2=O)c(F)cc1NC(=O)c1occc1C CHEMBL4764083 EC50 77.0 nM
Cc1nc2c(cnn2-c2ccccc2)c(=O)n1-c1ccc(Br)cc1 CHEMBL248208 IC50 78.0 nM
Cc1ccoc1C(=O)Nc1cc(F)c(N2C(=O)c3ccccc3C2=O)cc1F CHEMBL4796783 EC50 78.0 nM
COc1ccnc2sc3c(=O)n(-c4ccc(C5CC5)cc4)ccc3c12 CHEMBL1951676 IC50 79.0 nM
CCc1cc2cc(C(=O)C3CCC(O)CC3)ccc2nc1C CHEMBL177585 IC50 80.0 nM
CN(C(=O)c1ccccc1)c1nc(-c2ccncc2)cs1 CHEMBL576121 IC50 80.0 nM
Cc1ccc(-c2csc3c(=O)n(-c4ccc(Cl)cc4)cnc23)cc1 CHEMBL3954190 IC50 80.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(Cl)cc3C2=O)c(Cl)c1 CHEMBL3628112 EC50 80.9 nM
CCCN(C(=O)c1ccc(F)cc1)c1nc(-c2ccccn2)cs1 CHEMBL567673 IC50 81.0 nM
CC1CCC(n2cnc3c(oc4nccc(N(C)C)c43)c2=O)CC1 CHEMBL224200 IC50 82.0 nM
O=c1c2sc3ncnc(NC4CC4)c3c2ncn1-c1ccc(F)cc1 CHEMBL2205372 IC50 82.0 nM
Cc1ccc(C(=O)N(C)c2nc(-c3ccncc3)cs2)cc1 CHEMBL579225 IC50 83.0 nM
CCc1ccc(-n2c(CC)nc3c(sc4nccc(N(C)C)c43)c2=O)cc1 CHEMBL225201 IC50 84.0 nM
CCc1cc2cc(C(=O)C3CCC(OC)CC3)ccc2nc1O CHEMBL441844 IC50 85.0 nM
CCc1cc2cc(C(=O)C[C@H]3CC[C@@H](OC)CC3)ccc2nc1C CHEMBL175699 IC50 85.0 nM
C#CCNc1ncnc2sc3c(=O)n(-c4ccc(OC)cc4F)cnc3c12 CHEMBL1784073 IC50 85.0 nM
COc1ccnc2sc3c(=O)n(-c4ccccc4C)ccc3c12 CHEMBL1951673 IC50 85.0 nM
O=C(N1C[C@@H]2CN(c3ccccn3)C[C@@H]2C1)C12CC3CC(CC(C3)C1)C2 CHEMBL2418364 IC50 85.0 nM
COc1ccc(-n2cnc3c(sc4ncnc(NCCO)c43)c2=O)cc1 CHEMBL2205912 IC50 86.0 nM
CN(C)c1ccnc2sc3c(=O)n(-c4ccc(C5CC5)cc4)cnc3c12 CHEMBL387687 IC50 87.0 nM
NCCCNCCCCNCCCNC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccc(-c2ccccc2)cc1 CHEMBL1269125 IC50 87.0 nM
CNc1ccnc2sc3c(=O)n(-c4ccc(OC)cc4F)ccc3c12 CHEMBL1951875 IC50 88.0 nM
CNc1ncnc2sc3c(=O)n(-c4ccc(OC)cc4)ccc3c12 CHEMBL1951884 IC50 88.0 nM
Cc1cc(NC(=O)c2occc2C)ccc1N1C(=O)c2ccccc2C1=O CHEMBL3634422 EC50 89.0 nM
Cc1nc2c(cnn2-c2ccccc2)c(=O)n1N1CCCCC1 CHEMBL248052 IC50 91.0 nM
CCOc1ccc(-c2nsc(NC(=O)[C@@H]3C[C@H]3C)c2C)cc1 CHEMBL2011873 IC50 92.0 nM
O=C(N1C[C@@H]2CN(c3cccc(F)n3)C[C@@H]2C1)C12CC3CC(CC(C3)C1)C2 CHEMBL2418380 IC50 93.0 nM
O=C1CN=C(c2ccoc2)C=C2c3cccc(I)c3CCN12 CHEMBL3702385 IC50 93.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)nc1 CHEMBL3634434 EC50 95.0 nM
COc1ccc(Nc2ncnc3ccc(OC)cc23)cc1 CHEMBL254575 IC50 96.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(Cl)c1 CHEMBL3628104 EC50 97.0 nM
C[C@@H]1CN(c2cccnc2C#N)CCN1C(=O)C12CC3CC(CC(C3)C1)C2 CHEMBL2397347 pIC50 97.72 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccncc3C2=O)c(Cl)c1 CHEMBL3628115 pEC50 97.72 nM
CCc1ccc(-n2cnc3c(sc4nccc(NC)c43)c2=O)cc1 CHEMBL374815 IC50 98.0 nM
CCc1ccc(-n2cnc3c(sc4nccc(NCC(F)(F)F)c43)c2=O)cc1 CHEMBL376372 IC50 99.0 nM
Cc1ccoc1C(=O)Nc1cc(F)c(N2C(=O)c3ccc(Cl)cc3C2=O)c(F)c1F CHEMBL4782646 EC50 99.0 nM
CCOC(=O)c1[nH]c(C)c(C(=O)OC2CC3CCC2C3)c1C CHEMBL396594 Log IC50 100.0 nM
CN(C(=O)c1cccc(F)c1)c1nc(-c2ccncc2)cs1 CHEMBL579213 IC50 100.0 nM
Cc1c(-c2ccc(F)cc2)nsc1NC(=O)[C@@H]1C[C@H]1C CHEMBL2011875 IC50 100.0 nM
CCCCc1nc2c(sc3nccc(N(C)C)c32)c(=O)n1-c1ccc(CC)cc1 CHEMBL387976 IC50 101.0 nM
C=C(C)CNc1ccnc2sc3c(=O)n(-c4ccc(OC)c(F)c4)cnc3c12 CHEMBL1783871 IC50 103.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)c(C(F)(F)F)c1 CHEMBL3634428 pIC50 104.71 nM
CCc1cc2cc(C(=O)C3CCC(OC)CC3)ccc2nc1NCCOC CHEMBL367227 IC50 105.0 nM
NCCCNCCCCNCCCNC(=O)[C@H](CC1CCCCC1)NC(=O)CC12CC3CC(CC(C3)C1)C2 CHEMBL1269127 IC50 105.0 nM
C#CCNc1ncnc2sc3c(=O)n(-c4ccc5c(c4)OCCO5)cnc3c12 CHEMBL1784048 IC50 106.0 nM
O=C(C1CC1c1ccc(N2CCOCC2)nc1)C12CC3CC(CC(C3)C1)C2 CHEMBL556070 Ki 110.0 nM
COc1ccc(-c2nsc(NC(=O)[C@H]3C[C@@H]3C)c2C)cc1 CHEMBL2011871 IC50 110.0 nM
Cc1ccc(-n2cnc3c(-c4ccccc4)csc3c2=O)cc1 CHEMBL3330808 IC50 112.0 nM
CCc1ccc(-n2cnc3c(sc4nccc(N5CCC5)c43)c2=O)cc1 CHEMBL225126 IC50 113.0 nM
COc1cccc(-n2ccc3c(sc4nccc(OC)c43)c2=O)c1 CHEMBL1951671 IC50 118.0 nM
CC(C)(C)CC(=O)N1CC=C(c2cn(-c3ccccc3F)nn2)CC1 CHEMBL461035 IC50 120.0 nM
CN(C)c1ccnc2sc3c(=O)n(-c4ccc5cn[nH]c5c4)cnc3c12 CHEMBL225438 IC50 122.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(C(F)(F)F)c1 CHEMBL3634426 EC50 123.0 nM
COc1ccc(-n2ccc3c(sc4nccc(NCCO)c43)c2=O)cc1 CHEMBL1951684 IC50 124.0 nM
CNCc1cn(CC(=O)Nc2sc3c(c2C(N)=O)CCCC3)nc1C(F)(F)F CHEMBL1258681 pEC50 125.89 nM
Cc1nc2c(cnn2-c2cccc(S(N)(=O)=O)c2)c(=O)n1-c1ccc(Cl)cc1 CHEMBL248233 IC50 127.0 nM
C=Cc1ccc(-n2cnc3c(-c4ccccc4)csc3c2=O)cc1 CHEMBL3330813 IC50 128.0 nM
CC1CCCCC1n1cnc2c(sc3nccc(N(C)C)c32)c1=O CHEMBL224672 IC50 130.0 nM
CN(C(=O)c1ccccc1F)c1nc(-c2ccncc2)cs1 CHEMBL567667 IC50 130.0 nM
Cc1ccc2c(c1)C(=O)N(c1cc(C)c(NC(=O)c3occc3C)cc1F)C2=O CHEMBL4777502 EC50 132.0 nM
COc1ccc(-n2ccc3c(sc4nccc(NC[C@@H](C)O)c43)c2=O)cc1 CHEMBL1951686 IC50 133.0 nM
O=c1c2scc(-c3ccccc3)c2ncn1-c1ccccc1 CHEMBL3330800 IC50 136.0 nM
C#CCNc1ncnc2sc3c(=O)n(-c4ccc5c(c4)OCO5)cnc3c12 CHEMBL1784074 IC50 137.0 nM
Cc1c(-c2ccc(O)cc2)nsc1NC(=O)[C@@H]1C[C@H]1C CHEMBL2011880 IC50 138.0 nM
CN(C)c1ccnc2sc3c(=O)n(CC4CCCCC4)cnc3c12 CHEMBL223868 IC50 139.0 nM
CC1CCC(n2cnc3c(sc4nccc(N(C)C)c43)c2=O)CC1 CHEMBL224315 IC50 140.0 nM
CC1(C)C2C(=O)N(c3ccc(NC(=O)c4ccccn4)cc3Cl)C(=O)C21 CHEMBL3628281 IC50 140.0 nM
Cc1ocnc1C(=O)Nc1ccc(N2C(=O)c3ccc(F)cc3C2=O)c(Cl)c1 CHEMBL3759381 EC50 141.0 nM
O=C(Nc1nc(C(F)(F)F)co1)C1c2ccccc2Oc2ccccc21 CHEMBL521982 pEC50 141.25 nM
COc1cc(NC(=O)c2occc2C)ccc1N1C(=O)c2cccc(F)c2C1=O CHEMBL3634432 EC50 144.0 nM
C=C(C[C@H](N)C(=O)O)C(=O)O CHEMBL38499 Ki 150.0 nM
O=C1CN=C(c2cccs2)C=C2c3cccc(C(F)(F)F)c3CCN12 CHEMBL3702359 IC50 150.0 nM
COc1ccc(-n2cnc3c(sc4ncnc(NCC5CC5)c43)c2=O)cc1 CHEMBL2205916 IC50 154.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(C(F)(F)F)c1 CHEMBL3634429 pIC50 154.88 nM
COCCNC(=O)c1[nH]cc(C(=O)OC2CC3CCC2C3)c1C CHEMBL233710 Log IC50 158.49 nM
O=C(CCc1ccccc1)c1ccc2nc3c(cc2c1)CCCO3 CHEMBL353547 IC50 160.0 nM
C=C1C[C@@H]2COC(=O)[C@]2(Cc2ccc3ccccc3c2)C1 CHEMBL254372 IC50 160.0 nM
C[C@@H]1CN(c2ccccn2)CCN1C(=O)C12CC3CC(CC(C3)C1)C2 CHEMBL2397349 IC50 161.0 nM
C[C@@H]1CN(C(=O)C23CC4CC(CC(C4)C2)C3)CCN1c1ccccn1 CHEMBL2397351 pIC50 165.96 nM
C[C@@H]1CN(c2ccccn2)CCN1C(=O)C1CC2CCCC(C2)C1 CHEMBL2397366 pIC50 165.96 nM
CN(C)c1ccnc2sc3c(=O)n(C4CCC4)cnc3c12 CHEMBL385776 IC50 167.0 nM
C[N+](C)([O-])c1ccnc2sc3c(=O)n(N4CCCCCC4)cnc3c12 CHEMBL386408 IC50 167.0 nM
CCC(=O)c1ccc(-c2nnn(-c3cccnc3)c2C)cc1 CHEMBL578565 IC50 170.0 nM
CCc1cn(C2=NCC(=O)N3CCc4c(cccc4-c4ccco4)C3=C2)cn1 CHEMBL3702423 IC50 170.0 nM
C#CC(C)(C)Nc1ccnc2sc3c(=O)n(-c4ccc(C)cc4)cnc3c12 CHEMBL1784080 IC50 171.0 nM
CCc1cc2cc(C(=O)[C@H]3CC[C@@H](OC)CC3)ccc2nc1C#N CHEMBL2112963 IC50 174.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2Cc3c(Cl)cccc3C2=O)c(Cl)c1 CHEMBL3785321 pEC50 177.83 nM
CCCc1ccc(-n2cnc3c(sc4nccc(N(C)C)c43)c2=O)cc1 CHEMBL426018 IC50 180.0 nM
Cc1cccc(-n2ncc3c(=O)n(-c4ccc(Cl)cc4)c(C)nc32)c1 CHEMBL400307 IC50 180.0 nM
N#Cc1csc(NC(=O)C2c3ccccc3Oc3ccccc32)n1 CHEMBL3797793 EC50 180.6 nM
CCc1ccc(-n2cnc3c(sc4cncc(N(C)C)c43)c2=O)cc1 CHEMBL224798 IC50 183.0 nM
Cc1cccc(-n2cnc3c(-c4ccccc4)csc3c2=O)c1 CHEMBL3330807 IC50 184.0 nM
N#Cc1ccccc1N1C[C@H]2CN(C(=O)C34CC5CC(CC(C5)C3)C4)C[C@H]2C1 CHEMBL2418383 IC50 185.0 nM
Cc1scnc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1 CHEMBL3759171 pEC50 186.21 nM
COc1ccc(-n2cnc3c(sc4nc(C)nc(N)c43)c2=O)cc1 CHEMBL1092275 IC50 188.0 nM
COc1cccc(-c2c(-c3ccc4nn(C)cc4c3)nsc2NC(=O)[C@@H]2C[C@H]2C)n1 CHEMBL2334977 IC50 190.0 nM
Cc1scnc1C(=O)Nc1ccc(N2C(=O)c3cccnc3C2=O)c(Cl)c1 CHEMBL3759573 pEC50 190.55 nM
CCc1cc2cc(C(=O)[C@H]3CC[C@@H](OC)CC3)ccc2nc1-c1ccsc1 CHEMBL2112965 IC50 191.0 nM
COCCNc1ccnc2sc3c(=O)n(-c4ccc(OC)cc4)ccc3c12 CHEMBL1951685 IC50 192.0 nM
COc1ccc(-n2cnc3c(sc4ncnc(Nc5cccc(F)c5)c43)c2=O)cc1 CHEMBL2205368 IC50 192.0 nM
C=C(C)CNc1ccnc2sc3c(=O)n(-c4ccc5c(c4)OCCO5)cnc3c12 CHEMBL1783872 IC50 196.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)nc1 CHEMBL3634436 EC50 198.0 nM
CC(=O)NCCCCNC(=O)c1[nH]cc(C(=O)OC2CC3CCC2C3)c1C CHEMBL233709 Log IC50 199.53 nM
N[C@@H](Cn1oc(=O)[nH]c1=O)C(=O)O CHEMBL279956 EC50 200.0 nM
CNc1ccnc2sc3c(=O)n(-c4ccc(C#N)cc4)ccc3c12 CHEMBL1951873 IC50 203.0 nM
CN(C)c1ncnc2sc3c(=O)n(-c4cccnc4)cnc3c12 CHEMBL2205929 IC50 204.0 nM
Cc1ccoc1C(=O)Nc1cnc(N2C(=O)c3cccc(Cl)c3C2=O)nc1 CHEMBL3634439 EC50 208.0 nM
C#CCNc1ncnc2sc3c(=O)n(-c4ccc5ncsc5c4)cnc3c12 CHEMBL1784076 IC50 209.0 nM
CN(C(=O)c1ccc(Br)cc1)c1nc(-c2ccncc2)cs1 CHEMBL565934 IC50 210.0 nM
Cc1c(-c2ccc(C(=O)NC(C)C)cc2)nnn1-c1cccnc1 CHEMBL565948 IC50 210.0 nM
COc1cccc2c1CCN1C(=O)CN=C(c3ccc(C)o3)C=C21 CHEMBL3702362 IC50 210.0 nM
C#CCNc1ncnc2sc3c(=O)n(-c4ccc(OC)c(F)c4)cnc3c12 CHEMBL1784071 IC50 212.0 nM
Cc1cc(N2C(=O)c3ccc(Cl)cc3C2=O)c(F)cc1NC(=O)c1occc1C CHEMBL4788523 EC50 217.0 nM
C#CCNc1ncnc2sc3c(=O)n(-c4ccc5sccc5c4)cnc3c12 CHEMBL1784078 IC50 219.0 nM
CC(C)c1csc(NC(=O)C2c3ccccc3Oc3ccccc32)n1 CHEMBL3799685 pEC50 219.28 nM
Cc1nc2c(cnn2-c2cccc(Cl)c2)c(=O)n1-c1ccc(Cl)cc1 CHEMBL399309 IC50 220.0 nM
CC(C)(C)OC(=O)N1CC=C(c2cn(-c3ccncc3)nn2)CC1 CHEMBL457873 IC50 220.0 nM
COCc1cn(C2=NCC(=O)N3CCc4c(cccc4C4CCC4)C3=C2)cn1 CHEMBL3702450 IC50 220.0 nM
CC1(C)C2C(=O)N(c3ccc(NC(=O)c4ccccn4)cc3)C(=O)C21 CHEMBL4787147 EC50 220.0 nM
COc1ccc(-n2cnc3c(-c4cccc(C)c4)csc3c2=O)cc1 CHEMBL3330824 IC50 221.0 nM
COc1ccc(-n2cnc3c(-c4ccccc4Cl)csc3c2=O)cc1 CHEMBL3330820 IC50 221.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)Cc3ccccc3C2=O)c(Cl)c1 CHEMBL3785245 pEC50 223.87 nM
O=C1CN=C(n2cnc(C3CC3)n2)C=C2c3cccc(C4CC4)c3CCN12 CHEMBL3644400 IC50 226.0 nM
Cc1cccc2c1C(=O)N(c1ccc(NC(=O)c3ncsc3C)cc1Cl)C2=O CHEMBL3760018 pEC50 229.09 nM
Cc1nc2c(cnn2-c2cccnc2)c(=O)n1-c1ccc(Cl)cc1 CHEMBL399128 IC50 230.0 nM
CN(C(=O)c1ccc(F)cc1)c1nc(-c2cccnc2)cs1 CHEMBL571687 IC50 230.0 nM
C[C@@H]1C[C@H]1C(=O)Nc1snc(-c2ccc3nn(C)cc3c2)c1-c1ccccn1 CHEMBL2334972 IC50 238.0 nM
Cc1nc2c(cnn2-c2ccccc2)c(=O)n1N1CCCCCC1 CHEMBL246609 IC50 240.0 nM
C=C(C)CNc1ccnc2sc3c(=O)n(-c4ccc5c(c4)OCO5)cnc3c12 CHEMBL1783873 IC50 241.0 nM
Cc1ocnc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1 CHEMBL3759878 EC50 241.0 nM
Cc1nc2c(cnn2-c2ccccc2)c(=O)n1-c1ccc(Cl)cc1 CHEMBL247438 IC50 242.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2Cc3c(Cl)cccc3C2=O)cc1 CHEMBL3786739 EC50 245.0 nM
N[C@@H](CCC(=O)O)C(=O)O CHEMBL575060 Ki 250.0 nM
Cc1c(-c2ccc3[nH]ccc3c2)nnn1-c1cccnc1 CHEMBL576637 IC50 250.0 nM
CCc1ccccc1-n1cnc2c(sc3nccc(N(C)C)c32)c1=O CHEMBL375439 IC50 251.0 nM
O=C(Cn1nc(C(F)(F)F)c2c1CCCC2)Nc1sc2c(c1C(=O)N[C@@H]1CCNC1)CCCC2 CHEMBL1234889 pEC50 251.19 nM
O=C(Cn1nc(C(F)(F)F)c2c1CCCC2)Nc1sc2c(c1CO)CCCC2 CHEMBL1258570 pEC50 251.19 nM
Cc1ccc2c(c1)C(=O)N(c1ccc(NC(=O)c3nccn3C)cc1Cl)C2=O CHEMBL3759555 pEC50 251.19 nM
C[C@@H]1CN(c2cccc(F)n2)CCN1C(=O)C12CC3CC(CC(C3)C1)C2 CHEMBL2397341 IC50 255.0 nM
COc1ccc(-n2cnc3c(-c4cccc(OC)c4)csc3c2=O)cc1 CHEMBL3330827 IC50 257.0 nM
C[C@@H]1CN(c2ccccc2C#N)CCN1C(=O)C12CC3CC(CC(C3)C1)C2 CHEMBL2397378 pIC50 263.03 nM
Cn1ccnc1C(=O)Nc1ccc(N2C(=O)c3ccc(Cl)cc3C2=O)c(Cl)c1 CHEMBL3759647 pEC50 263.03 nM
COc1ccc(-n2cnc3c(sc4ncnc(Nc5ccccc5)c43)c2=O)cc1 CHEMBL2205919 IC50 277.0 nM
CCc1cccc(-c2c(-c3ccc4nn(C)cc4c3)nsc2NC(=O)[C@@H]2C[C@H]2C)n1 CHEMBL2334976 IC50 279.0 nM
CN(C)c1ccnc2sc3c(=O)n(Cc4ccccc4)cnc3c12 CHEMBL388087 IC50 281.0 nM
COCc1cn(C2=NCC(=O)N3CCc4c(ccc(F)c4C4CC4)C3=C2)cn1 CHEMBL3644421 IC50 289.0 nM
O=C(Nc1ccc(N2C(=O)[C@@H]3[C@H](C2=O)[C@H]2C=C[C@H]3C2)c(Cl)c1)c1ccccn1 CHEMBL3628280 EC50 291.0 nM
O=C(N1C[C@@H]2CN(c3ccccn3)C[C@@H]2C1)N1CCC2(CCCC2)C1 CHEMBL2418359 pIC50 295.12 nM
Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cn1 CHEMBL497917 IC50 300.0 nM
Cc1c(-c2ccc3ccccc3c2)nnn1-c1cccnc1 CHEMBL567584 IC50 300.0 nM
CCc1ccc(-n2cnc3c(sc4nccc([N+](C)(C)[O-])c43)c2=O)cc1 CHEMBL390391 IC50 306.0 nM
Cc1cc(N2C(=O)c3ccccc3C2=O)c(C)cc1NC(=O)c1occc1C CHEMBL4800540 EC50 306.0 nM
C#CC(C)Nc1ccnc2sc3c(=O)n(-c4ccc(C)cc4)cnc3c12 CHEMBL1784079 IC50 314.0 nM
COCCNC(=O)c1[nH]c(C)c(C(=O)OC2CC3CCC2C3)c1C CHEMBL428850 Log IC50 316.23 nM
CNCc1cn(CC(=O)Nc2sc3c(c2C(N)=O)CCCC3)nc1C(C)(C)C CHEMBL1234888 pEC50 316.23 nM
CN(C)Cc1cn(CC(=O)Nc2sc3c(c2C(N)=O)CCCC3)nc1C(C)(C)C CHEMBL1257298 pEC50 316.23 nM
Cc1ccc(-n2cnc3c(sc4nc(C5CC5)nc(N)c43)c2=O)cc1 CHEMBL1093987 IC50 326.0 nM
COc1cc(N2C(=O)c3ccccc3C2=O)ccc1NC(=O)c1occc1C CHEMBL3634449 EC50 330.0 nM
CCC(CC)n1cnc2c(sc3nccc(N(C)C)c32)c1=O CHEMBL223819 IC50 335.0 nM
C[C@@H]1CN(c2ncccc2C#N)CCN1C(=O)C12CC3CC(CC(C3)C1)C2 CHEMBL2397344 IC50 344.0 nM
N[C@](CC1c2ccccc2Sc2ccccc21)(C(=O)O)[C@H]1C[C@@H](C(=O)O)C1 CHEMBL92162 Ki 350.0 nM
Cc1ccccc1-n1ncc2c(=O)n(-c3ccc(Cl)cc3)c(C)nc21 CHEMBL246611 IC50 350.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2Cc3cccc(Cl)c3C2=O)cc1 CHEMBL3785400 EC50 353.0 nM
Cn1ccnc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(Cl)c1 CHEMBL3758364 pEC50 354.81 nM
C#CC(CC)(CC)Nc1ccnc2sc3c(=O)n(-c4ccc(C)cc4)cnc3c12 CHEMBL1784081 IC50 358.0 nM
O=C(N1CCC2(CCCCC2)CC1)N1C[C@@H]2CN(c3ccccn3)C[C@@H]2C1 CHEMBL2418361 pIC50 363.08 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)nc1 CHEMBL3634433 EC50 387.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2Cc3c(Br)cccc3C2=O)c(Cl)c1 CHEMBL3785382 pEC50 389.05 nM
O=C(Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)c(Cl)c1)c1ncccc1Cl CHEMBL3628116 EC50 390.0 nM
CC(C)c1cccc(-c2c(-c3ccc4nn(C)cc4c3)nsc2NC(=O)C2CC2)n1 CHEMBL2334989 IC50 397.0 nM
C[C@@H]1CN(c2ccncc2C#N)CCN1C(=O)C12CC3CC(CC(C3)C1)C2 CHEMBL2397346 IC50 398.0 nM
O=C1CN=C(n2cnc(C3CC3)c2)C=C2c3cccc(-c4cncc(F)n4)c3CCN12 CHEMBL3644415 IC50 402.0 nM
CC(C)c1ccc(-n2cnc3c(sc4nccc(N(C)C)c43)c2=O)cc1 CHEMBL374167 IC50 407.0 nM
O=c1c2scc(-c3ccccc3)c2ncn1-c1ccccc1Cl CHEMBL3330803 IC50 407.0 nM
O=c1c2scc(-c3ccccc3)c2ncn1-c1ccccc1F CHEMBL3329236 IC50 407.0 nM
CCCc1cccc(-c2c(-c3ccc4nn(C)cc4c3)nsc2NC(=O)[C@@H]2C[C@H]2C)n1 CHEMBL2334980 IC50 409.0 nM
C[C@@H]1CN(c2ccc(F)cn2)CCN1C(=O)C12CC3CC(CC(C3)C1)C2 CHEMBL2397342 IC50 414.0 nM
COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@]12C[C@H]1/C(=N\O)c1ccccc1O2 CHEMBL2111944 IC50 430.0 nM
Cc1ccc(-n2cnc3c(sc4ncc5sc(=O)[nH]c5c43)c2=O)cc1 CHEMBL392164 IC50 446.0 nM
O=c1c2scc(-c3ccc4c(c3)OCO4)c2ncn1-c1ccc(Cl)cc1 CHEMBL3942033 IC50 447.0 nM
CCc1cc2cc(C(=O)[C@H]3CC[C@@H](OC)CC3)ccc2n2nnnc12 CHEMBL176068 IC50 450.0 nM
Cc1cccc2c1C(=O)N(c1ccc(NC(=O)c3ncoc3C)cc1Cl)C2=O CHEMBL3759424 EC50 469.0 nM
CC(=O)c1ccc(-c2nnn(-c3cccnc3)c2C)cc1 CHEMBL565972 IC50 470.0 nM
O=C(N1C[C@@H]2CN(c3ccc(F)cn3)C[C@@H]2C1)C12CC3CC(CC(C3)C1)C2 CHEMBL2418381 IC50 478.0 nM
CC1CCCC(n2cnc3c(sc4nccc(N(C)C)c43)c2=O)C1 CHEMBL388827 IC50 482.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2Cc3cccc(Cl)c3C2=O)c(Cl)c1 CHEMBL3786400 EC50 484.0 nM
C=C(C)c1cccc2c1CCN1C(=O)CN=C(n3cnc(COC)c3)C=C21 CHEMBL3644395 IC50 490.0 nM
Cc1ccccc1-n1cnc2c(-c3ccccc3)csc2c1=O CHEMBL3330806 IC50 499.0 nM
CN(C)Cc1cn(CC(=O)Nc2sc3c(c2C(N)=O)CCCC3)nc1C(F)(F)F CHEMBL1258795 pEC50 501.19 nM
Cc1cc(N2C(=O)c3ccccc3C2=O)c(F)cc1NC(=O)c1occc1C CHEMBL4780280 EC50 508.0 nM
COc1ncn(C2=NCC(=O)N3CCc4c(cccc4C4CC4)C3=C2)n1 CHEMBL3644401 IC50 511.0 nM
Cc1nc2c(cnn2C2CCCCCC2)c(=O)n1-c1ccc(Cl)cc1 CHEMBL400110 IC50 520.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)c(C(F)(F)F)c1 CHEMBL3634427 EC50 530.0 nM
COc1cccc(C2=NCC(=O)N3CCc4c(ccc(Cl)c4OC)C3=C2)c1 CHEMBL3702367 IC50 530.0 nM
COCc1cn(C2=NCC(=O)N3CCc4c(cccc4C4CC4)C3=C2)cn1 CHEMBL3644420 IC50 540.0 nM
Cc1ccc(-n2cnc3c(sc4ncc5sc(=S)[nH]c5c43)c2=O)cc1 CHEMBL429635 IC50 541.0 nM
N#Cc1ncccc1N1C[C@H]2CN(C(=O)C34CC5CC(CC(C5)C3)C4)C[C@H]2C1 CHEMBL2418356 pIC50 549.54 nM
O=C(Nc1ccc(N2C(=O)c3ccccc3C2=O)c(Cl)c1)c1ccco1 CHEMBL3628081 pEC50 549.54 nM
Cc1ccc2c(c1)C(=O)N(c1ccc(NC(=O)c3[nH]ncc3C)cc1Cl)C2=O CHEMBL3759656 EC50 557.0 nM
O=C1CN=C(n2cnc(C3CC3)c2)C=C2c3cccc(-c4ccno4)c3CCN12 CHEMBL3644422 IC50 560.0 nM
COCc1cn(C2=NCC(=O)N3CCc4c(cc(F)cc4C4CC4)C3=C2)cn1 CHEMBL3702467 IC50 561.0 nM
COc1ccc(-n2c(C)nc3c(-c4ccccc4)csc3c2=O)cc1 CHEMBL3968177 IC50 564.0 nM
COc1cc(C2=NCC(=O)N3CCc4c(OC)cccc4C3=C2)ccn1 CHEMBL3702358 IC50 585.0 nM
COc1ccccc1-n1cc(C2=CCN(C(=O)OC(C)(C)C)CC2)nn1 CHEMBL461033 IC50 590.0 nM
Cc1ccoc1C(=O)Nc1cc(F)c(N2C(=O)c3ccccc3C2=O)c(F)c1F CHEMBL4742005 EC50 591.0 nM
C[C@@H]1CN(c2cccnc2)CCN1C(=O)C12CC3CC(CC(C3)C1)C2 CHEMBL2397368 IC50 596.0 nM
N#Cc1c(NCc2ccccc2)sc2c1CCN(C(=O)c1ccc(F)cc1)C2 CHEMBL3422882 IC50 600.0 nM
O=C(N1CCN(c2nccs2)CC1)C12CC3CC(CC(C3)C1)C2 CHEMBL1688377 IC50 630.0 nM
CCN(CC)Cc1cn(CC(=O)Nc2sc3c(c2C(N)=O)CCCC3)nc1C(F)(F)F CHEMBL1257181 pEC50 630.96 nM
NC(=O)c1c(NC(=O)Cn2cc(CNC3CC3)c(C(F)(F)F)n2)sc2c1CCCC2 CHEMBL1258914 pEC50 630.96 nM
Cc1cn[nH]c1C(=O)Nc1ccc(N2C(=O)c3ccc(F)cc3C2=O)c(Cl)c1 CHEMBL3759376 pEC50 630.96 nM
CN(C)c1ccnc2sc3c(=O)n(C4CC4)cnc3c12 CHEMBL224135 IC50 632.0 nM
CSc1nc2c(cnc3sc4c(=O)n(-c5ccc(C)cc5)cnc4c32)s1 CHEMBL235767 IC50 636.0 nM
Cc1ncn(C2=NCC(=O)N3CCc4c(cccc4C4CCC4)C3=C2)n1 CHEMBL3702451 IC50 636.0 nM
CC(C)c1cccc(-c2c(-c3ccc4nn(C)cc4c3)nsc2NC(=O)[C@@H]2C[C@H]2C)n1 CHEMBL2334981 IC50 644.0 nM
CCc1cccc2c1CCN1C(=O)CN=C(n3cnc(C(C)C)c3)C=C21 CHEMBL3702448 IC50 650.0 nM
CC(=O)c1cccc2c1CCN1C(=O)CN=C(n3cnc(C4CCC4)c3)C=C21 CHEMBL3644392 IC50 660.0 nM
COc1ccc(-n2cnc3c(-c4ccc(C)cc4)csc3c2=O)cc1 CHEMBL3330825 IC50 661.0 nM
O=C(N1C[C@@H]2CN(c3cnccn3)C[C@@H]2C1)C12CC3CC(CC(C3)C1)C2 CHEMBL2418379 IC50 669.0 nM
O=C1CN=C(n2cnc(CF)c2)C=C2c3cccc(C4CC4)c3CCN12 CHEMBL3639432 IC50 672.0 nM
Cn1ccnc1C(=O)Nc1ccc(N2C(=O)c3ccc(F)cc3C2=O)c(Cl)c1 CHEMBL3758986 EC50 673.0 nM
C[C@@H]1C[C@H]1C(=O)Nc1snc(-c2ccc3nn(C)cc3c2)c1-c1cccc(C2CCC2)n1 CHEMBL2334983 IC50 687.0 nM
COCc1cn(C2=NCC(=O)N3CCc4c(C5CC5)ccc(F)c4C3=C2)cn1 CHEMBL3702465 IC50 687.0 nM
COc1cccc2c1CCN1C(=O)CN=C(c3ccn(C)n3)C=C21 CHEMBL3702365 IC50 690.0 nM
O=C1CN=C(n2cnc(C(F)F)c2)C=C2c3cccc(C4CC4)c3CCN12 CHEMBL3644362 IC50 702.0 nM
C[C@@H]1CN(c2ncccn2)CCN1C(=O)C12CC3CC(CC(C3)C1)C2 CHEMBL2397372 pIC50 707.95 nM
C[C@@H]1CN(c2ncccc2F)CCN1C(=O)C12CC3CC(CC(C3)C1)C2 CHEMBL2397343 pIC50 707.95 nM
O=C1CN=C(n2cnc(CO)c2)C=C2c3cccc(C4CC4)c3CCN12 CHEMBL3644428 IC50 712.0 nM
C[C@@H]1C[C@H]1C(=O)Nc1snc(-c2ccc3nn(C)cc3c2)c1-c1cccc(C2CC2)n1 CHEMBL2334982 IC50 735.0 nM
COc1ccc(-n2cnc3c(-c4ccccc4OC)csc3c2=O)cc1 CHEMBL3330826 IC50 747.0 nM
Cc1ccoc1C(=O)Nc1cnc(N2C(=O)c3cccc(C)c3C2=O)nc1 CHEMBL3634438 EC50 751.0 nM
Cc1nc2c(cnn2-c2ccccc2)c(=O)n1C1CCCCCC1 CHEMBL246840 IC50 760.0 nM
O=C1CN=C(n2cnc(C3CC3)n2)C=C2c3cccc(-c4nccs4)c3CCN12 CHEMBL3702443 IC50 761.0 nM
O=C(N1CCC2(CCCC2)CC1)N1C[C@@H]2CN(c3ccccn3)C[C@@H]2C1 CHEMBL2418360 IC50 769.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2CCc3ccccc3C2=O)c(Cl)c1 CHEMBL3785252 pEC50 776.25 nM
NCc1cn(CC(=O)Nc2sc3c(c2C(N)=O)CCCC3)nc1C(F)(F)F CHEMBL1258571 pEC50 794.33 nM
CCNCc1cn(CC(=O)Nc2sc3c(c2C(N)=O)CCCC3)nc1C(F)(F)F CHEMBL1234887 pEC50 794.33 nM
CCNCc1cn(CC(=O)Nc2sc3c(c2C(N)=O)CCCC3)nc1C(C)(C)C CHEMBL1257415 pEC50 794.33 nM
Cc1nc2c(cnn2-c2ccccc2)c(=O)n1-c1ccc(Cl)c(F)c1 CHEMBL246839 IC50 800.0 nM
O=C1CN=C(c2cccs2)C=C2c3cccc(F)c3CCN12 CHEMBL3702372 IC50 800.0 nM
COCc1ncn(C2=NCC(=O)N3CCc4c(ccc(F)c4C4CC4)C3=C2)n1 CHEMBL3644365 IC50 814.0 nM
N#Cc1ccncc1N1C[C@H]2CN(C(=O)C34CC5CC(CC(C5)C3)C4)C[C@H]2C1 CHEMBL2418385 pIC50 831.76 nM
Cc1cn[nH]c1C(=O)Nc1ccc(N2C(=O)c3ccc(Cl)cc3C2=O)c(Cl)c1 CHEMBL3759211 pEC50 851.14 nM
Cc1ccoc1C(=O)Nc1ccc(N2Cc3c(F)cccc3C2=O)c(Cl)c1 CHEMBL3786160 EC50 878.0 nM
Cc1c(-c2ccc(C(=O)N(C)C(C)C)cc2)nnn1-c1cccnc1 CHEMBL576434 IC50 880.0 nM
COCc1cn(C2=NCC(=O)N3CCc4c(C5=CCCC5)cccc4C3=C2)cn1 CHEMBL3644394 IC50 890.0 nM
C[C@@H]1C[C@H]1C(=O)Nc1snc(-c2ccc3nn(C)cc3c2)c1-c1cccc(C2CCCC2)n1 CHEMBL2334984 IC50 891.0 nM
COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@]12C[C@@H]1/C(=N\O)c1ccccc1O2 CHEMBL2111943 IC50 930.0 nM
Cc1ccoc1C(=O)Nc1ccc(NC(=O)c2ccccc2C(=O)O)c(Cl)c1 CHEMBL3786597 EC50 930.0 nM
CCc1cc(C2=NCC(=O)N3CCc4c(OC)cccc4C3=C2)ccn1 CHEMBL3702364 IC50 940.0 nM
CCc1ccc(-n2cnc3c(sc4cccc(N(C)C)c43)c2=O)cc1 CHEMBL389918 IC50 949.0 nM
Cc1scnc1C(=O)Nc1ccc(N2Cc3c(Cl)cccc3C2=O)c(Cl)c1 CHEMBL3785499 EC50 954.0 nM
C=C(C)CNc1ncnc2sc3c(=O)n(-c4ccncc4)cnc3c12 CHEMBL1784060 IC50 955.0 nM
C[C@H]1CN(C(=O)C23CC4CC(CC(C4)C2)C3)CCN1c1ccccn1 CHEMBL2397350 pIC50 977.24 nM
O=C(Nc1nc(-c2ccccn2)cs1)c1ccc(F)cc1 CHEMBL572145 IC50 980.0 nM
CC(=O)NCCCCNC(=O)c1[nH]c(C)c(C(=O)OC2CC3CCC2C3)c1C CHEMBL233914 Log IC50 1000.0 nM
NC(C(=O)O)(C1CC(C(=O)O)C1)C1c2ccccc2Sc2ccccc21 CHEMBL401721 IC50 1000.0 nM
NC(=O)c1c(NC(=O)Cn2cc(CN3CCC3)c(C(F)(F)F)n2)sc2c1CCCC2 CHEMBL1257182 pEC50 1000.0 nM
NC(=O)c1c(NC(=O)Cn2nc(C(F)(F)F)c3c2CCNC3)sc2c1CCCC2 CHEMBL1258461 pEC50 1000.0 nM
O=C(N1C[C@@H]2CN(c3ncccc3F)C[C@@H]2C1)C12CC3CC(CC(C3)C1)C2 CHEMBL2418382 IC50 1000.0 nM