N[C@@]1(C(=O)O)C[S+]([O-])[C@H]2[C@H](C(=O)O)[C@H]21 CHEMBL218710 EC50 0.089 nM
N[C@@]1(C(=O)O)CC(=O)[C@H]2[C@H](C(=O)O)[C@H]21 CHEMBL2381640 EC50 0.16 nM
COc1ccc(-c2cc(C(N)=O)nc3cc(CCc4cnc(C)nc4)ccc23)c(F)c1 CHEMBL3955188 Ki 0.19 nM
N#Cc1ncc(CCc2ccc3c(-c4ccc(F)cc4)cc(C(N)=O)nc3c2)cn1 CHEMBL5405921 Ki 0.32 nM
FC(F)(F)c1c(O[C@H]2CC[C@H](c3ccccc3)CC2)ccn2c(CC3CC3)nnc12 CHEMBL3884532 EC50 0.4 nM
Fc1ccc(C2CC(Oc3ccn4c(CC5CC5)nnc4c3C(F)(F)F)C2)cc1 CHEMBL3883435 EC50 0.4 nM
COc1ccc(-c2cc(C(N)=O)nc3cc(CCc4cnc(C)nc4)ccc23)cc1F CHEMBL3945590 Ki 0.46 nM
FC(F)(F)c1c(OC2CC(c3ccccc3)C2)ccn2c(CC3CC3)nnc12 CHEMBL3884187 EC50 0.5 nM
N[C@@]1(C(=O)O)C[C@@H](F)[C@H]2[C@H](C(=O)O)[C@H]21 CHEMBL2381652 EC50 0.56 nM
N[C@@]1(C(=O)O)CC(=O)[C@@H]2[C@H]1[C@@]2(F)C(=O)O CHEMBL121053 Activity 0.57 nM
N[C@@]1(C(=O)O)C[C@H](Sc2nnc(C(F)F)[nH]2)[C@H]2[C@H](C(=O)O)[C@H]21 CHEMBL3616857 EC50 0.58 nM
N[C@@]1(C(=O)O)C[C@H](Sc2nnc(C(F)(F)F)[nH]2)[C@H]2[C@H](C(=O)O)[C@H]21 CHEMBL3616856 EC50 0.65 nM
NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CCc3ccc(CF)nc3)cc2n1 CHEMBL5409898 Ki 0.7 nM
Cc1ccc(-c2cc(C(N)=O)nc3cc(CCc4cnc(C)nc4)ccc23)c(F)c1 CHEMBL5418895 Ki 0.74 nM
NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CCc3cnc(F)nc3)cc2n1 CHEMBL5429000 Ki 0.78 nM
Cc1ncc(CCc2ccc3c(-c4ccc(F)cc4)cc(C(N)=O)nc3c2)cn1 CHEMBL5394450 Ki 0.8 nM
O[C@]1(C2CC2)CC[C@H](Nc2ccc(-c3ccn4c(CC5CC5)nnc4c3C(F)(F)F)cc2Cl)CC1 CHEMBL4063313 pKi 0.8913 nM
NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CCc3ccc(F)nc3)cc2n1 CHEMBL5435246 Ki 0.96 nM
FC(F)(F)c1c(OC[C@H]2C[C@@H]2c2ccc(Cl)cc2)ccn2c(CC3CC3)nnc12 CHEMBL3885379 Ki(app) 1.0 nM
Cc1ccc(Oc2ccc(-c3ccn4c(CC5CC5)nnc4c3Cl)cc2Cl)c(C)n1 CHEMBL4074664 Kd 1.0 nM
N#Cc1ccc(CCc2ccc3c(-c4ccc(F)cc4)cc(C(N)=O)nc3c2)cn1 CHEMBL5429261 Ki 1.0 nM
CCOc1cc(-c2nc(-c3cc(C)nc(C)c3)c3n2C[C@@H](C)OCC3)ccc1C(F)(F)F CHEMBL4108184 IC50 1.1 nM
Fc1cc(-c2ccn3c(CC4CC4)nnc3c2C(F)(F)F)ccc1NC1CC1 CHEMBL4087196 Kd 1.1 nM
NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CCc3cccnc3)cc2n1 CHEMBL3979547 Ki 1.1 nM
Cc1ccc(CCc2ccc3c(-c4ccc(F)cc4)cc(C(N)=O)nc3c2)cn1 CHEMBL5436775 Ki 1.1 nM
FC(F)(F)c1c(-c2ccc(NC3CC3)c(Cl)c2)ccn2c(CC3CC3)nnc12 CHEMBL4073628 Kd 1.2 nM
C=C1C[C@@](N)(C(=O)O)[C@H]2[C@@H]1[C@@H]2C(=O)O CHEMBL2381641 EC50 1.3 nM
FC(F)(F)c1c(OCC2CC2c2ccc(Cl)cc2)ccn2c(CC3CC3)nnc12 CHEMBL3884636 EC50 1.3 nM
NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CCc3cncnc3)cc2n1 CHEMBL3950572 Ki 1.4 nM
NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CCc3cnc(CF)nc3)cc2n1 CHEMBL5405655 Ki 1.5 nM
Cc1ccc(Oc2ccc(-c3ccn4c(CC5CC5)nnc4c3C(F)(F)F)cc2Cl)c(C)n1 CHEMBL4101354 pKi 1.514 nM
Fc1ccc(C2CC2COc2ccn3c(CC4CC4)nnc3c2C(F)(F)F)cc1 CHEMBL3883634 EC50 1.7 nM
CCOc1cc(-c2nc(-c3ccnc(C)c3)c3n2C[C@@H](C)OCC3)ccc1C(F)(F)F CHEMBL4112479 IC50 1.7 nM
CCOc1ccc(-c2nc(-c3cc(C)nc(C)c3)c3n2C[C@@H](CF)OCC3)cc1C CHEMBL4109246 IC50 1.7 nM
Cc1ncc(CCc2ccc3c(-c4ccc(CF)cc4)cc(C(N)=O)nc3c2)cn1 CHEMBL5410262 Ki 1.7 nM
FC(F)(F)c1c(OCC2(c3ccccc3)CCCCC2)ccn2c(CC3CC3)nnc12 CHEMBL3884094 EC50 1.8 nM
Cc1cc(-c2nc(-c3ccc(OC4CC4)c(Cl)c3)n3c2CCO[C@H](CF)C3)cc(C)n1 CHEMBL4108743 IC50 1.8 nM
Cc1cc(-c2nc(-c3ccc(OC(C)C)c(C)c3)n3c2CCO[C@H](CF)C3)cc(C)n1 CHEMBL4110543 IC50 1.8 nM
NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CN3C(=O)CCC3=O)cc2n1 CHEMBL3892073 Ki 1.8 nM
Cc1cc(-c2nc(-c3ccc(OC(F)(F)F)c(C)c3)n3c2CCO[C@H](C)C3)ccn1 CHEMBL4109319 IC50 1.9 nM
Cc1cc(-c2nc(-c3ccc(OC(F)F)c(CF)c3)n3c2CCO[C@H](C)C3)cc(C)n1 CHEMBL4112624 IC50 1.9 nM
O[C@H]1CC[C@H](Oc2ccc(-c3ccn4c(CC5CC5)nnc4c3C(F)(F)F)cc2Cl)CC1 CHEMBL4077609 pKi 1.905 nM
Cc1ccc(Oc2ccc(-c3ccn4c(CC5CC5)nnc4c3Cl)cc2F)c(C)n1 CHEMBL4075258 pKi 1.95 nM
Cc1cc(-c2nc(-c3ccc(OC(F)F)c(Cl)c3)n3c2CCO[C@H](CF)C3)cc(C)n1 CHEMBL4107872 IC50 2.0 nM
COc1ccc(CNc2ccc(-c3ccn4c(CC5CC5)nnc4c3C(F)(F)F)cc2)cn1 CHEMBL4093657 Kd 2.0 nM
COc1ccc(CNc2ccc(-c3ccn4c(CC5CC5)nnc4c3C(F)(F)F)cc2F)cn1 CHEMBL4091370 pKi 2.042 nM
CCOCc1nnc2c(C(F)(F)F)c(-c3ccc(Oc4ccc(C)nc4C)c(F)c3)ccn12 CHEMBL4067298 Kd 2.1 nM
O[C@H]1CC[C@H](Nc2ccc(-c3ccn4c(CC5CC5)nnc4c3C(F)(F)F)cc2Cl)CC1 CHEMBL4104081 pKi 2.188 nM
N[C@]1(C(=O)O)[C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)c(Cl)c1)[C@]2(F)C(=O)O CHEMBL186453 Ki 2.2 nM
CC(C)Nc1ccc(-c2ccn3c(CC4CC4)nnc3c2C(F)(F)F)cc1F CHEMBL4088239 Kd 2.2 nM
COc1cc(-c2nc(-c3cc(C)nc(CF)c3)c3n2C[C@@H](CF)OCC3)ccc1C(F)(F)F CHEMBL4108163 IC50 2.4 nM
Cc1cc(-c2nc(-c3ccc(OC(F)(F)F)c(CF)c3)n3c2CCO[C@H](C)C3)cc(C)n1 CHEMBL4107913 IC50 2.4 nM
Cc1cc(-c2nc(-c3ccc(OC(C)C)c(C)c3)n3c2CCO[C@H](C)C3)cc(C)n1 CHEMBL4108918 IC50 2.4 nM
Cc1cc(-c2nc(-c3ccc(OC(F)(F)F)c(CF)c3)n3c2CCO[C@H](C)C3)ccn1 CHEMBL4111659 IC50 2.5 nM
Cc1ccc(Oc2ccc(-c3ccn4c(CC5CC5)nnc4c3C(F)(F)F)cc2F)c(C)n1 CHEMBL4080973 Kd 2.5 nM
CC1(c2ccccc2)CCCN(Cc2ccn3c(CC4CC4)nnc3c2C(F)(F)F)C1 CHEMBL3901998 EC50 2.6 nM
COc1ccc(-c2cc(C(N)=O)nc3cc(CCc4cnc(C)nc4)ccc23)cc1 CHEMBL3895570 Ki 2.6 nM
N[C@@]1(C(=O)O)CO[C@H]2[C@H](C(=O)O)[C@H]21 CHEMBL275079 EC50 2.69 nM
COc1cc(-c2nc(-c3cc(C)nc(C)c3)c3n2C[C@@H](CF)OCC3)ccc1OC(F)(F)F CHEMBL4113834 IC50 2.7 nM
Cc1cc(-c2nc(-c3ccc(OC(C)C)c(Cl)c3)n3c2CCO[C@H](C)C3)cc(C)n1 CHEMBL4113466 IC50 2.7 nM
Cc1cc(-c2nc(-c3ccc(OC(F)F)c(Cl)c3)n3c2CCO[C@H](C)C3)cc(C)n1 CHEMBL4112598 IC50 2.8 nM
CCOc1ccc(-c2nc(-c3cc(C)nc(C)c3)c3n2C[C@@H](C)OCC3)cc1Cl CHEMBL4112321 IC50 2.8 nM
N[C@](CC1c2ccccc2Oc2ccccc21)(C(=O)O)[C@H]1C[C@@H]1C(=O)O CHEMBL432038 IC50 2.9 nM
Cc1cc(-c2nc(-c3ccc(OC(F)F)c(CF)c3)n3c2CCO[C@H](C)C3)ccn1 CHEMBL4111276 IC50 2.9 nM
CCOc1ccc(-c2nc(-c3cc(C)nc(C)c3)c3n2C[C@@H](C)OCC3)cc1C CHEMBL4111924 IC50 2.9 nM
C[C@H]1CN(Cc2nc3ncccc3n2C)CC[C@H]1c1ccc(C(F)(F)F)cc1F CHEMBL1774233 EC50 3.0 nM
Cc1cc(-c2nc(-c3ccc(OC4CC4)c(Cl)c3)n3c2CCO[C@H](C)C3)cc(C)n1 CHEMBL4115420 IC50 3.0 nM
Cc1cc(-c2nc(-c3ccc(OC(F)(F)F)c(Cl)c3)n3c2CCO[C@H](C)C3)ccn1 CHEMBL4113300 IC50 3.0 nM
O[C@H]1CC[C@H](Nc2ccc(-c3ccn4c(CC5CC5)nnc4c3Cl)cc2Cl)CC1 CHEMBL4074421 pKi 3.02 nM
Cc1cc(-c2nc(-c3ccc(F)c(OCC4CCC4)c3)n3c2CCO[C@H](C)C3)cc(C)n1 CHEMBL4108816 IC50 3.1 nM
COc1cc(-c2nc(-c3cc(C)nc(C)c3)c3n2C[C@@H](C)OCC3)ccc1OC(F)(F)F CHEMBL4111755 IC50 3.2 nM
Cc1ccc(Oc2ccc(-c3ccn4c(CC(F)(F)F)nnc4c3Cl)cc2F)c(C)n1 CHEMBL4093792 Kd 3.3 nM
Cc1cc(-c2nc(-c3ccc(OC4CC4)c(C)c3)n3c2CCO[C@H](C)C3)cc(C)n1 CHEMBL4111744 IC50 3.4 nM
CC(C)Nc1ccc(-c2ccn3c(CC4CC4)nnc3c2C(F)(F)F)cc1Cl CHEMBL4067421 Kd 3.4 nM
N[C@](CC1c2ccccc2Oc2ccccc21)(C(=O)O)[C@H]1C[C@]1(F)C(=O)O CHEMBL409928 IC50 3.49 nM
Cc1cc(-c2nc(-c3ccc(OC(F)F)c(C)c3)n3c2CCO[C@H](CF)C3)cc(C)n1 CHEMBL4111773 IC50 3.5 nM
Fc1cc(-c2ccn3c(CC4CC4)nnc3c2C(F)(F)F)ccc1Oc1ccnc(C2CC2)c1 CHEMBL4072262 pKi 3.631 nM
Cc1cc(-c2nc(-c3ccc(OC(F)(F)F)c(C#N)c3)n3c2CCO[C@H](CF)C3)cc(C)n1 CHEMBL4115199 IC50 3.7 nM
N[C@@]1(C(=O)O)C[C@H](NC(=O)c2cccc(O)c2)[C@H]2[C@H](C(=O)O)[C@H]21 CHEMBL4091735 EC50 3.77 nM
COc1cc(-c2nc(-c3ccnc(C)c3)c3n2C[C@@H](CF)OCC3)ccc1OC(F)(F)F CHEMBL4110721 IC50 3.8 nM
COc1cc(-c2nc(-c3cc(C)nc(C)c3)c3n2C[C@@H](CF)OCC3)ccc1C(F)(F)F CHEMBL4115490 IC50 3.8 nM
CC[C@@H]1Cn2c(-c3ccc(Cl)c(OC)c3)nc(-c3ccnc(C)c3)c2CCO1 CHEMBL4108564 IC50 3.8 nM
Cc1cc(-c2nc(-c3ccc(OC(F)(F)F)c(C#N)c3)n3c2CCO[C@H](CF)C3)ccn1 CHEMBL4107975 IC50 3.8 nM
FC(F)(F)c1c(-c2ccc(NC3CCOCC3)c(Cl)c2)ccn2c(CC3CC3)nnc12 CHEMBL4064589 Kd 3.8 nM
N[C@@]1(C(=O)O)CSC2C1[C@H]2C(=O)O CHEMBL88999 Ki 3.9 nM
N[C@@]1(C(=O)O)CS[C@H]2[C@H](C(=O)O)[C@H]21 CHEMBL8839 EC50 3.9 nM
CCOc1cc(-c2nc(-c3cc(C)nc(C)c3)c3n2C[C@@H](C)OCC3)ccc1C CHEMBL4112442 IC50 3.9 nM
FC(F)(F)c1c(OC[C@@H]2C[C@H]2c2ccc(Cl)cc2)ccn2c(CC3CC3)nnc12 CHEMBL3884833 EC50 4.0 nM
Cc1cc(-c2nc(-c3ccc(OC(F)(F)F)c(C)c3)n3c2CCO[C@H](CF)C3)cc(C)n1 CHEMBL4113929 IC50 4.0 nM
Cc1cc(-c2nc(-c3ccc(OC(F)(F)F)c(C)c3)n3c2CCO[C@H](C)C3)cc(CF)n1 CHEMBL4111952 IC50 4.0 nM
COc1c(F)ccc(F)c1C1CCN(c2ccn3c(CC4CC4)nnc3c2C(F)(F)F)CC1 CHEMBL2206449 EC50 4.1 nM
Cc1cc(-c2nc(-c3ccc(OC4CC4)c(C)c3)n3c2CCO[C@H](CF)C3)cc(C)n1 CHEMBL4113962 IC50 4.1 nM
COc1cc(-c2nc(-c3ccnc(C)c3)c3n2C[C@@H](CF)OCC3)ccc1C(F)(F)F CHEMBL4107140 IC50 4.1 nM
N[C@]1(C(=O)O)[C@@H]2[C@@H](C(=O)O)[C@@H]2[C@H](O)[C@H]1CSc1ccc(F)c(F)c1 CHEMBL4751065 IC50 4.1 nM
O=C(NCc1ccc(-c2ccn3c(CC4CC4)nnc3c2C(F)(F)F)cc1)c1ccc(S(=O)(=O)F)cc1 CHEMBL4589377 pKi 4.169 nM
COc1cc(-c2nc(-c3cc(C)nc(C)c3)c3n2C[C@@H](C)OCC3)ccc1C(F)(F)F CHEMBL4110444 IC50 4.2 nM
CCc1ccc(-c2nc(-c3cc(C)nc(C)c3)c3n2C[C@@H](C)OCC3)cc1OC CHEMBL4113601 IC50 4.2 nM
Cc1cc(-c2nc(-c3ccc(OC(F)(F)F)c(C#N)c3)n3c2CCO[C@H](C)C3)cc(C)n1 CHEMBL4108541 IC50 4.2 nM
Cc1cc(-c2nc(-c3ccc(OC(F)(F)F)cc3)n3c2CCO[C@H](C)C3)cc(CF)n1 CHEMBL4112898 IC50 4.4 nM
Cc1cc(-c2nc(-c3ccc(OC(F)(F)F)c(Cl)c3)n3c2CCO[C@H](C)C3)cc(C)n1 CHEMBL4114150 IC50 4.4 nM
COc1cc(-c2nc(-c3cc(C)nc(CF)c3)c3n2C[C@@H](C)OCC3)ccc1C(F)(F)F CHEMBL4107565 IC50 4.4 nM
NC(CC1c2ccccc2Oc2ccccc21)(C(=O)O)C1CC1(F)C(=O)O CHEMBL259435 IC50 4.45 nM
Nc1nnc(S[C@@H]2C[C@@](N)(C(=O)O)[C@@H]3[C@@H](C(=O)O)[C@@H]32)[nH]1 CHEMBL3616851 EC50 4.5 nM
Cc1cc(-c2nc(-c3ccc(C(F)(F)F)c(C)c3)n3c2CCO[C@H](C)C3)cc(C)n1 CHEMBL4106709 IC50 4.5 nM
COc1ncc(CCc2ccc3c(-c4ccc(F)cc4)cc(C(N)=O)nc3c2)cn1 CHEMBL5429002 Ki 4.5 nM
Cc1cc(-c2nc(-c3ccc(OC(F)(F)F)c(C#N)c3)n3c2CCO[C@H](C)C3)ccn1 CHEMBL4108785 IC50 4.6 nM
Cc1cc(-c2nc(-c3ccc(OC(F)F)c(C)c3)n3c2CCO[C@H](CF)C3)ccn1 CHEMBL4115237 IC50 4.7 nM
Cc1cc(-c2nc(-c3ccc(OC(F)(F)F)c(C)c3)n3c2CCO[C@H](C)C3)cc(C)n1 CHEMBL4115390 IC50 4.7 nM
Cc1cc(-c2nc(-c3ccc(OC4CC4)c(C)c3)n3c2CCO[C@H](C)C3)cc(CF)n1 CHEMBL4112889 IC50 4.7 nM
COc1ccc(-c2nc(-c3cc(C)nc(CF)c3)c3n2C[C@@H](C)OCC3)cc1OC(F)(F)F CHEMBL4110332 IC50 4.7 nM
FC(F)(F)c1c(N2CCC(c3ccccc3)CC2)ccn2c(CC3CC3)nnc12 CHEMBL2179319 EC50 4.8 nM
COc1cc(-c2nc(-c3ccnc(C)c3)c3n2C[C@@H](C)OCC3)ccc1OC(F)(F)F CHEMBL4110153 IC50 4.8 nM
Cc1cc(-c2nc(-c3ccc(OC(F)(F)F)c(C#N)c3)n3c2CCO[C@H](C)C3)cc(CF)n1 CHEMBL4106969 IC50 4.9 nM
CC(Oc1ccc(CN2C[C@@H](C)OC2=O)cc1)C1CCCCC1 CHEMBL484340 EC50 5.0 nM
Cc1ccc(-c2cc(C(N)=O)nc3cc(CN4C(=O)CCC4=O)ccc23)cc1 CHEMBL3971388 IC50 5.0 nM
NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(C(O)Cc3cccnc3)cc2n1 CHEMBL3964644 IC50 5.0 nM
COc1ccc(-c2cc(C(N)=O)nc3cc(C(C)Cc4cccnc4)ccc23)cc1 CHEMBL3946016 IC50 5.0 nM
COc1cc(F)c(-c2cc(C(N)=O)nc3cc(CCc4cnc(C)nc4)ccc23)c(F)c1 CHEMBL3923126 IC50 5.0 nM
COc1ccc(-c2nc(-c3cc(C)nc(C)c3)c3n2C[C@@H](C)OCC3)cc1Cl CHEMBL4115497 IC50 5.0 nM
Cc1cc(-c2nc(-c3ccc(OC4CC4)c(Cl)c3)n3c2CCO[C@H](C)C3)ccn1 CHEMBL4112623 IC50 5.0 nM
Cc1cc(-c2nc(-c3ccc(OC(F)(F)F)c(C)c3)n3c2CCO[C@H](CF)C3)ccn1 CHEMBL4114409 IC50 5.0 nM
COc1cc(-c2nc(-c3cc(C)nc(C(F)F)c3)c3n2C[C@@H](C)OCC3)ccc1OC(F)F CHEMBL4108588 IC50 5.0 nM
N[C@@]1(C(=O)O)CC[C@H]2[C@H](C(=O)O)[C@H]21 CHEMBL8759 EC50 5.1 nM
COc1cc(-c2nc(-c3cc(C)nc(CF)c3)c3n2C[C@@H](CF)OCC3)ccc1OC(F)F CHEMBL4113756 IC50 5.1 nM
N[C@@]1(C(=O)O)C[C@H](Sc2c[nH]nn2)[C@H]2[C@H](C(=O)O)[C@H]21 CHEMBL3616860 EC50 5.2 nM
COc1cc(-c2nc(-c3cc(C)nc(CF)c3)c3n2C[C@@H](C)OCC3)ccc1OC(F)(F)F CHEMBL4107066 IC50 5.2 nM
Cc1cc(-c2nc(-c3ccc(OC(F)F)c(C)c3)n3c2CCO[C@H](C)C3)cc(CF)n1 CHEMBL4110839 IC50 5.2 nM
COc1ccc(-c2nc(-c3cc(C)nc(C)c3)c3n2C[C@@H](CF)OCC3)cc1C CHEMBL4110505 IC50 5.2 nM
COc1ccccc1C1CCN(c2ccn3c(CC4CC4)nnc3c2Cl)CC1 CHEMBL2206440 EC50 5.2 nM
Cc1cc(SC[C@@H]2[C@@H](Sc3nc[nH]n3)[C@H]3[C@H](C(=O)O)[C@H]3[C@]2(N)C(=O)O)ccc1F CHEMBL4759992 Ki 5.2 nM
FC(F)(F)c1c(-c2ccc(OC3CCOCC3)c(Cl)c2)ccn2c(CC3CC3)nnc12 CHEMBL4067290 pKi 5.248 nM
Cc1cc(-c2nc(-c3ccc(OC4CC4)c(Cl)c3)n3c2CCO[C@H](C)C3)cc(CF)n1 CHEMBL4107266 IC50 5.3 nM
Cc1cc(-c2nc(-c3ccc(OC(C)C)c(Cl)c3)n3c2CCO[C@H](CF)C3)cc(C)n1 CHEMBL4110578 IC50 5.4 nM
CC(C)(COc1ccn2c(CC3CC3)nnc2c1C(F)(F)F)c1ccc(Cl)cc1 CHEMBL3884936 EC50 5.5 nM
COc1cc(F)cc(F)c1C1CCN(c2ccn3c(CC4CC4)nnc3c2Cl)CC1 CHEMBL2206447 IC50 5.6 nM
N[C@@]1(C(=O)O)C[C@@H](Sc2nnc[nH]2)[C@H]2[C@H](C(=O)O)[C@H]21 CHEMBL3616847 EC50 5.6 nM
Cc1cc(-c2nc(-c3ccc(OC(F)F)c(C)c3)n3c2CCO[C@H](C)C3)cc(C)n1 CHEMBL4110486 IC50 5.6 nM
COc1cc(-c2nc(-c3cc(C)nc(CF)c3)c3n2C[C@@H](C)OCC3)ccc1Cl CHEMBL4109709 IC50 5.7 nM
Cc1cc(-c2nc(-c3ccc(Cl)c(C(F)(F)F)c3)n3c2CCO[C@H](C)C3)cc(C)n1 CHEMBL4108148 IC50 5.7 nM
CCOc1cc(-c2nc(-c3cc(C)nc(C)c3)c3n2C[C@@H](C)OCC3)ccc1CC CHEMBL4109004 IC50 5.9 nM
COc1cccc(F)c1C1CCN(c2ccn3c(CC4CC4)nnc3c2Cl)CC1 CHEMBL2206442 EC50 6.0 nM
CC(=O)c1ccc(OCc2cccc(Oc3cc(-c4nn[nH]n4)ccn3)c2)c(C(F)(F)F)c1O CHEMBL3965244 EC50 6.0 nM
Cn1cc(-c2cc(C(N)=O)nc3cc(Cc4ccnc(C(F)(F)F)c4)ccc23)cn1 CHEMBL3983863 IC50 6.0 nM
COc1ccc(-c2cc(C(N)=O)nc3cc(C(C)Cc4cnc(C)nc4)ccc23)c(F)c1 CHEMBL3973721 IC50 6.0 nM
COc1ccc(-c2cc(C(N)=O)nc3cc(C(O)Cc4ccc(Cl)nc4)ccc23)cc1 CHEMBL3966866 IC50 6.0 nM
COc1ccc(-c2cc(C(N)=O)nc3cc(CCc4cnc(C#N)nc4)ccc23)c(F)c1 CHEMBL3941863 IC50 6.0 nM
CCOc1ccc(-c2nc(-c3cc(C)nc(C)c3)c3n2C[C@@H](CF)OCC3)cc1Cl CHEMBL4107197 IC50 6.0 nM
Cc1cc(-c2nc(-c3ccc(OC(F)F)c(C)c3)n3c2CCO[C@H](CF)C3)cc(CF)n1 CHEMBL4115246 IC50 6.0 nM
Fc1cc(Cl)ccc1-c1ccc(Cn2nnc3c(Br)cccc32)cn1 CHEMBL4587631 EC50 6.0 nM
CC1(C)CCc2c(-c3ccc(F)cc3F)cc(C(N)=O)nc2O1 CHEMBL5076351 IC50 6.0 nM
O[C@H]1CC[C@H](Nc2ccc(-c3ccn4c(CC(F)(F)F)nnc4c3Cl)cc2Cl)CC1 CHEMBL4075762 pKi 6.026 nM
FC(F)(F)c1c(OCC(F)(F)c2ccccc2)ccn2c(CC3CC3)nnc12 CHEMBL3885115 EC50 6.1 nM
Clc1cc(-c2ccn3c(CC4CC4)nnc3c2Cl)ccc1NC1CC1 CHEMBL4060306 Kd 6.1 nM
O=C(Nc1ccc(-c2ccn3c(CC4CC4)nnc3c2C(F)(F)F)cc1)c1ccc(S(=O)(=O)F)cc1 CHEMBL4538850 pKi 6.166 nM
COc1cc(-c2nc(-c3cc(C)nc(C(F)F)c3)c3n2C[C@@H](C)OCC3)ccc1C CHEMBL4107211 IC50 6.3 nM
N[C@@]1(C(=O)O)C[C@H](NC(=O)c2ccc(O)cc2)[C@H]2[C@H](C(=O)O)[C@H]21 CHEMBL4070866 EC50 6.32 nM
Nc1nnc(S[C@H]2C[C@@](N)(C(=O)O)[C@@H]3[C@@H](C(=O)O)[C@@H]32)[nH]1 CHEMBL3616858 EC50 6.4 nM
CCOCc1nnc2c(Cl)c(-c3ccc(Oc4ccc(C)nc4C)c(F)c3)ccn12 CHEMBL4089612 pKi 6.457 nM
COc1ccc(-c2nc(-c3cc(C)nc(C)c3)c3n2C[C@@H](C)OCC3)cc1OC(F)(F)F CHEMBL4106932 IC50 6.7 nM
NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(Cc3cccnc3)cc2n1 CHEMBL3910265 Ki 6.7 nM
Clc1c(OCc2ccc(-c3ccccc3)cc2)ccn2c(CC3CC3)nnc12 CHEMBL3883801 EC50 6.8 nM
C[C@H]1CN(c2ccc(C(F)(F)F)c(Cl)c2)C(=O)c2c(-c3ccnc(C#N)c3)cnn21 CHEMBL3421840 pIC50 6.918 nM
N[C@@]1(C(=O)O)C[C@H](NC(=O)c2ccc(Cl)cc2)[C@H]2[C@H](C(=O)O)[C@H]21 CHEMBL4095567 EC50 6.97 nM
Cc1cc(-c2cccc(C3=Nc4cc(Cl)c(Cl)cc4NC(=O)C3)c2)ccn1 CHEMBL1629864 IC50 7.0 nM
CC1CC=C(c2cc(C(N)=O)nc3cc(CN4C(=O)CCC4=O)ccc23)CC1 CHEMBL3958138 IC50 7.0 nM
Cn1cc(-c2cc(C(N)=O)nc3cc(Cc4cc(Cl)nc(C(F)(F)F)c4)ccc23)cn1 CHEMBL3961599 IC50 7.0 nM
COc1ccc(-c2cc(C(N)=O)nc3cc(CCc4cnc(C#N)nc4)ccc23)cc1 CHEMBL3937970 IC50 7.0 nM
COc1ccc(-c2cc(C(N)=O)nc3cc(CCc4cncnc4N)ccc23)cc1 CHEMBL3925177 IC50 7.0 nM
NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(Cc3ccncc3)cc2n1 CHEMBL5425858 Ki 7.0 nM
Cc1cc(Oc2ccc(-c3ccn4c(CC5CC5)nnc4c3C(F)(F)F)cc2F)ccn1 CHEMBL4103808 pKi 7.079 nM
COc1cc(-c2nc(-c3cc(C)nc(C(F)F)c3)c3n2C[C@@H](CF)OCC3)ccc1C CHEMBL4114419 IC50 7.1 nM
COc1ccc(F)c(F)c1C1CCN(c2ccn3c(CC4CC4)nnc3c2Cl)CC1 CHEMBL2206446 IC50 7.3 nM
COc1cc(-c2nc(-c3cc(C)nc(CO)c3)c3n2C[C@@H](CF)OCC3)ccc1C(F)(F)F CHEMBL4114578 IC50 7.3 nM
O=C(c1cnc2c(cnn2CC2CC2)c1C(F)(F)F)N1CCN(c2ccc(F)cc2F)CC1 CHEMBL5202739 EC50 7.317 nM
Cc1cc(-c2nc(-c3ccc(OC(F)F)c(C)c3)n3c2CCO[C@H](C)C3)ccn1 CHEMBL4107040 IC50 7.4 nM
Cc1cc(-c2nc(-c3ccc(C)c(C(F)(F)F)c3)n3c2CCO[C@H](C)C3)cc(C)n1 CHEMBL4110709 IC50 7.4 nM
COc1ccc(CNc2ccc(-c3ccn4c(CC5CC5)nnc4c3Cl)cc2)cn1 CHEMBL4072134 pKi 7.413 nM
N[C@]1(C(=O)O)[C@@H]2[C@@H](C(=O)O)[C@@H]2[C@H](Sc2nc[nH]n2)[C@H]1OCc1ccc(Cl)c(Cl)c1 CHEMBL3969063 Ki 7.43 nM
N[C@@]1(C(=O)O)C[C@H](NC(=O)c2ccccc2O)[C@H]2[C@H](C(=O)O)[C@H]21 CHEMBL4068189 EC50 7.44 nM
COc1c(F)ccc(F)c1C1CCN(c2ccn3c(CC4CC4)nnc3c2Cl)CC1 CHEMBL2206445 EC50 7.5 nM
N[C@@]1(C(=O)O)C[C@H](O)[C@H]2[C@H](C(=O)O)[C@H]21 CHEMBL2381643 EC50 7.5 nM
Cc1cc(-c2nc(-c3ccc(OC(F)F)c(Cl)c3)n3c2CCO[C@H](C)C3)ccn1 CHEMBL4108597 IC50 7.5 nM
FC(F)(F)c1c(CN2CCC(c3ccccc3)CC2)ccn2c(CC3CC3)nnc12 CHEMBL3947764 pKi 7.586 nM
N[C@@]1(C(=O)O)C[C@@H](O)[C@H]2[C@H](C(=O)O)[C@H]21 CHEMBL2381642 EC50 7.6 nM
CCc1ccc(-c2nc(-c3ccnc(C)c3)c3n2C[C@@H](C)OCC3)cc1OC CHEMBL4113208 IC50 7.6 nM
Cc1cc(-c2nc(-c3ccc(OC(F)(F)F)cc3)n3c2CCO[C@H](C)C3)cc(C)n1 CHEMBL4113495 IC50 7.8 nM
CC1CN(Cc2ccc(OC(C)C3CCCCC3)cc2)C(=O)O1 CHEMBL484731 EC50 7.9 nM
COc1cc(-c2nc(-c3cc(C)nc(C(F)F)c3)c3n2C[C@@H](CF)OCC3)ccc1C(F)(F)F CHEMBL4110899 IC50 7.9 nM
CCOc1cc(-c2nc(-c3ccnc(C)c3)c3n2C[C@@H](C)OCC3)ccc1CC CHEMBL4115297 IC50 7.9 nM
COc1ccc(C2CCN(c3ccn4c(CC5CC5)nnc4c3Cl)CC2)cc1 CHEMBL4632373 EC50 7.9 nM
C[C@H]1[C@H](C(=O)O)[C@H]1[C@H](N)C(=O)O CHEMBL334160 Activity 8.0 nM
COc1ccc(-c2cc(C(N)=O)nc3cc(CN4C(=O)CCC4=O)ccc23)c(F)c1 CHEMBL3894283 IC50 8.0 nM
C[C@@H]1CO[C@@H](C(F)(F)F)CN1Cc1ccc2c(-c3cnn(C)c3)cc(C(N)=O)nc2c1 CHEMBL4110317 IC50 8.0 nM
C[C@H]1CO[C@@H](C(F)(F)F)CN1Cc1ccc2c(-c3cnn(C)c3)cc(C(N)=O)nc2c1 CHEMBL3912615 IC50 8.0 nM
Cn1cc(-c2cc(C(N)=O)nc3cc(CN4C[C@H](C(F)(F)F)OCC4(C)C)ccc23)cn1 CHEMBL4106729 IC50 8.0 nM
Cc1nn(C)cc1-c1cc(C(N)=O)nc2cc(CN3C[C@@H](C)O[C@@H](C(F)(F)F)C3)ccc12 CHEMBL4108673 IC50 8.0 nM
NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(Cc3ccnc(CO)c3)cc2n1 CHEMBL3937038 IC50 8.0 nM
CCC(O)(c1cn(Cc2ccc3c(-c4ccc(OC)cc4F)cc(C(N)=O)nc3c2F)cn1)C(F)(F)F CHEMBL3959134 IC50 8.0 nM
COc1ccc(-c2cc(C(N)=O)nc3cc(C(C)Cc4cnc(C#N)nc4)ccc23)cc1 CHEMBL3971450 IC50 8.0 nM
COc1ccc(-c2cc(C(N)=O)nc3cc(C(C)Cc4cccnc4)ccc23)c(F)c1 CHEMBL3939455 IC50 8.0 nM
COc1ccc(-c2cc(C(N)=O)nc3cc(C(C)Cc4ccc(CF)nc4)ccc23)cc1 CHEMBL3904730 IC50 8.0 nM
O[C@H]1CC[C@@H](Oc2ccc(-c3ccn4c(CC(F)(F)F)nnc4c3Cl)cc2Cl)CC1 CHEMBL4100691 Kd 8.1 nM
COc1ccc(F)cc1C1CCN(c2ccn3c(CC4CC4)nnc3c2Cl)CC1 CHEMBL2206441 EC50 8.2 nM
[N-]=[N+]=N[C@@H]1C[C@@](N)(C(=O)O)[C@@H]2[C@@H](C(=O)O)[C@@H]21 CHEMBL2381644 EC50 8.2 nM
N#Cc1cc(C2=Nc3ccc(Br)cc3NC(=O)C2)ccn1 CHEMBL5085417 IC50 8.3 nM
Fc1cc(Cl)ccc1N1CCN(Cc2ccn3c(CC4CC4)nnc3c2C(F)(F)F)CC1 CHEMBL5208947 EC50 8.3 nM
N[C@@]1(C(=O)O)C[C@H](NC(=O)c2cccc(Cl)c2)[C@H]2[C@H](C(=O)O)[C@H]21 CHEMBL4071962 EC50 8.37 nM
Cc1cc(-c2nc(-c3ccc(Cl)c(C(F)F)c3)n3c2CCOCC3)ccn1 CHEMBL3901364 IC50 8.4 nM
N[C@]1(C(=O)O)[C@@H]2[C@@H](C(=O)O)[C@@H]2[C@H](O)[C@H]1CSc1ccc(Cl)c(Cl)c1 CHEMBL4748699 Ki 8.4 nM
COc1ccc(COc2ccc(-c3ccn4c(CC5CC5)nnc4c3C(F)(F)F)cc2)cn1 CHEMBL4076786 Kd 8.7 nM
COCCOc1ccc(C2CCN(c3ccn4c(CC5CC5)nnc4c3Cl)CC2)cc1 CHEMBL4645305 EC50 8.7 nM
Cc1cc(SC[C@@H]2[C@@H](O)[C@H]3[C@H](C(=O)O)[C@H]3[C@]2(N)C(=O)O)ccc1F CHEMBL4780402 Ki 8.9 nM
Cc1cc(-c2cnn3c2C(=O)N(c2ccc(C(F)(F)F)cc2)C[C@@H]3C)ccn1 CHEMBL3421838 pIC50 8.913 nM
C[C@H]1CNC(C(F)(F)F)CN1Cc1ccc2c(-c3ccc(F)cc3)cc(C(N)=O)nc2c1 CHEMBL3903459 IC50 9.0 nM
Cc1ncc(-c2cc(C(N)=O)nc3cc(CN4CCOC(C(F)(F)F)C4)ccc23)s1 CHEMBL3985872 IC50 9.0 nM
NC(=O)c1cc(-c2cnn(CF)c2)c2ccc(CN3CCO[C@@H](C(F)(F)F)C3)cc2n1 CHEMBL4109555 IC50 9.0 nM
COc1ccc(-c2cc(C(N)=O)nc3cc(CCc4cccnc4N)ccc23)cc1 CHEMBL3983820 IC50 9.0 nM
COc1ccc(-c2cc(C(N)=O)nc3cc(CCc4cccnc4N)ccc23)c(F)c1 CHEMBL3954035 IC50 9.0 nM
COc1ccc(-c2cc(C(N)=O)nc3cc(C(C)Cc4ccc(CF)nc4)ccc23)c(F)c1 CHEMBL3936681 IC50 9.0 nM
COc1cc(-c2nc(-c3cc(C)nc(C(F)F)c3)c3n2C[C@@H](CF)OCC3)ccc1OC(F)F CHEMBL4110033 IC50 9.0 nM
COCCOc1ccccc1C1CCN(c2ccn3c(CC4CC4)nnc3c2Cl)CC1 CHEMBL4643961 EC50 9.0 nM
Cn1c(=O)n(CC(C)(C)C)c2ccc(C3=CC4CCC3CN4C(=O)c3ccon3)nc21 CHEMBL3939174 EC50 9.08 nM
Cc1cc(-c2nc(-c3ccc(C(F)(F)F)c(Cl)c3)n3c2CCOCC3)cc(C)n1 CHEMBL3951588 IC50 9.1 nM
COc1cc(-c2nc(-c3cc(C)nc(C)c3)c3n2C[C@@H](C)OCC3)ccc1C(F)F CHEMBL4111531 IC50 9.1 nM
CC(=O)N[C@H]1[C@H]2[C@H](C(=O)O)[C@H]2[C@](N)(C(=O)O)[C@@H]1CSc1ccc(F)c(C)c1 CHEMBL4746125 Ki 9.2 nM
O[C@H]1CC[C@@H](Nc2ccc(-c3ccn4c(CC5CC5)nnc4c3C(F)(F)F)cc2Cl)CC1 CHEMBL4076639 pKi 9.333 nM
Cc1cc(-c2nc(-c3ccc(OC(F)(F)F)c(F)c3)n3c2CCO[C@H](CF)C3)cc(C)n1 CHEMBL4115328 IC50 9.4 nM
COc1cc(-c2nc(-c3cc(C)nc(C)c3)c3n2C[C@@H](C)OCC3)ccc1OC(F)F CHEMBL4109036 IC50 9.6 nM
C[C@@H]1CN(Cc2ccc3c(-c4cnn(C)c4)cc(C(N)=O)nc3c2)C[C@H](C(F)(F)F)O1 CHEMBL4111091 IC50 9.6 nM
Fc1cccc(F)c1C1CCN(Cc2ccn3c(CC4CC4)nnc3c2C(F)(F)F)CC1 CHEMBL3910866 EC50 9.7 nM
Cc1cc(-c2nc(-c3ccc(OC4COC4)c(Cl)c3)n3c2CCO[C@H](C)C3)cc(C)n1 CHEMBL4113408 IC50 9.7 nM
COc1cccc(C2CCN(c3ccn4c(CC5CC5)nnc4c3Cl)CC2)c1 CHEMBL4646835 EC50 9.9 nM