Cc1cc(S(=O)(=O)n2cc(NC(=O)c3ccccn3)cn2)cnc1Cl CHEMBL3951144 EC50 2.05e-07 nM
O=C(Nc1cnn(S(=O)(=O)c2ccc3c(c2)OCO3)c1)c1ccccn1 CHEMBL3908205 EC50 2.16e-07 nM
O=C(Nc1cnn(S(=O)(=O)c2cnc3ccccc3c2)c1)c1ccccn1 CHEMBL3976997 EC50 2.23e-07 nM
O=C(Nc1cnn(S(=O)(=O)c2ccc3c(c2)OCCCO3)c1)c1ccccn1 CHEMBL3920208 EC50 2.4e-07 nM
O=C(Nc1cnn(S(=O)(=O)c2ccc3occc3c2)c1)c1ccccn1 CHEMBL3968624 EC50 2.5e-07 nM
O=C(Nc1cnn(S(=O)(=O)c2ccc3c(c2)OCCO3)c1)c1ccccn1 CHEMBL3981140 EC50 3.35e-07 nM
O=C(Nc1cnn(S(=O)(=O)c2cccc(Cl)n2)c1)c1ccccn1 CHEMBL3957595 EC50 4.48e-07 nM
COc1ccc(S(=O)(=O)n2cc(NC(=O)c3ccccn3)cn2)cn1 CHEMBL3905207 EC50 6.4e-07 nM
O=C(Nc1cnn(S(=O)(=O)c2ccc(Cl)nc2)c1)c1ccccn1 CHEMBL3944196 EC50 1.01e-06 nM
O=C(Nc1cnn(S(=O)(=O)c2ccsc2)c1)c1ccccn1 CHEMBL3942167 EC50 1.06e-06 nM
Cc1ccc(S(=O)(=O)n2cc(NC(=O)c3ccccn3)cn2)o1 CHEMBL3919802 EC50 1.28e-06 nM
CC1(C)CCc2ccc(S(=O)(=O)n3cc(NC(=O)c4ccccn4)cn3)cc2O1 CHEMBL3937681 EC50 1.5e-06 nM
O=C(Nc1cnn(S(=O)(=O)c2ccc(N3CCOCC3)cc2)c1)c1ccccn1 CHEMBL3969428 EC50 1.82e-06 nM
O=C(Nc1cnn(S(=O)(=O)c2ccoc2)c1)c1ccccn1 CHEMBL3952345 EC50 2.31e-06 nM
O=C(Nc1cnn(S(=O)(=O)c2ccco2)c1)c1ccccn1 CHEMBL3892049 EC50 2.45e-06 nM
Cc1nc(C)c(S(=O)(=O)n2cc(NC(=O)c3ccccn3)cn2)s1 CHEMBL3935369 EC50 6.42e-06 nM
O=C(Nc1cnn(S(=O)(=O)c2cccnc2Cl)c1)c1ccccn1 CHEMBL3976007 EC50 7.37e-06 nM
CCc1cnc(Oc2ccc(NC(=O)c3ncccc3N)cc2Cl)nc1 CHEMBL3798517 EC50 0.065 nM
Nc1cccnc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(Cl)c1 CHEMBL3798234 EC50 0.095 nM
Nc1cccnc1C(=O)Nc1ccc(N2Cc3ccccc3C2=O)c(Cl)c1 CHEMBL3798197 EC50 0.236 nM
COc1ccc2c(c1)C(=O)N(c1ccc(NC(=O)c3ncccc3N)cc1Cl)C2 CHEMBL3797445 EC50 0.319 nM
Cc1cccc2c1C(=O)N(c1ccc(NC(=O)c3ncccc3N)cc1Cl)C2=O CHEMBL3799261 EC50 0.689 nM
Nc1cccnc1C(=O)Nc1ccc(N2CC(Cc3ccccc3)CC2=O)c(Cl)c1 CHEMBL3797923 EC50 0.758 nM
Nc1cccnc1C(=O)Nc1ccc(N2CCc3ccccc3C2=O)c(Cl)c1 CHEMBL3797463 EC50 0.921 nM
Nc1cccnc1C(=O)Nc1ccc(N2Cc3ncccc3C2=O)c(Cl)c1 CHEMBL3797390 EC50 1.25 nM
Nc1cccnc1C(=O)Nc1ccc(N2CC3(CCCCC3)CC2=O)c(Cl)c1 CHEMBL3798366 EC50 1.28 nM
Cc1ncc(Oc2ccc(NC(=O)c3ncccc3N)cc2Cl)cn1 CHEMBL3798239 EC50 1.35 nM
CC(C)CC1CC(=O)N(c2ccc(NC(=O)c3ncccc3N)cc2Cl)C1 CHEMBL3799708 EC50 1.61 nM
Nc1cccnc1C(=O)Nc1ccc(N2CC(c3c(F)cccc3Cl)CC2=O)c(Cl)c1 CHEMBL3797777 EC50 1.86 nM
Nc1cccnc1C(=O)Nc1ccc(N2Cc3ccccc3CC2=O)c(Cl)c1 CHEMBL3798945 EC50 2.19 nM
Nc1cccnc1C(=O)Nc1ccc(N2CC(c3cccnc3)CC2=O)c(Cl)c1 CHEMBL3799281 EC50 2.52 nM
CC1(C2CC2)CC(=O)N(c2ccc(NC(=O)c3ncccc3N)cc2Cl)C1 CHEMBL3799999 EC50 2.8 nM
O=C(Nc1ccc(Cl)c(OCF)c1)c1ccccn1 CHEMBL3609741 IC50 3.2 nM
[2H]C([2H])(F)Oc1cc(NC(=O)c2ccccn2)ccc1Cl CHEMBL3609742 IC50 3.2 nM
[2H]C([2H])(F)Oc1cccc(NC(=O)c2ccccn2)c1 CHEMBL3609743 IC50 3.7 nM
CC1c2ccccc2C(=O)N1c1ccc(NC(=O)c2ncccc2N)cc1Cl CHEMBL3798583 EC50 3.96 nM
Cc1ccnc(Nc2nc(-c3cn[nH]c3)c(C)s2)n1 CHEMBL3609729 EC50 4.0 nM
O/N=c1\cc(-c2cc3sccc3cn2)oc2ccc(OC3CN(c4cccnc4)C3)cc12 CHEMBL4097743 EC50 4.0 nM
Cc1ncccc1N1CCC(Cc2ccc3oc(-c4cc5sccc5cn4)c/c(=N\O)c3c2)CC1 CHEMBL4070594 EC50 4.0 nM
O=C(Nc1cccc(OC(F)F)c1)c1ccccn1 CHEMBL541754 pIC50 4.571 nM
CSc1cccc(NC(=O)c2ccccn2)c1 CHEMBL1300476 pIC50 4.898 nM
COc1cc(NC(=O)c2ccccn2)ccc1Cl CHEMBL562551 IC50 5.1 nM
N#Cc1cc(NC(=O)c2ccccn2)ccc1Cl CHEMBL3609738 pIC50 5.248 nM
CC(=O)N1CCC(COc2ccc3oc(-c4cc5sccc5cn4)c/c(=N\O)c3c2)CC1 CHEMBL4105462 EC50 6.0 nM
O=C(Nc1cccc(OC(F)F)c1)c1cccc(F)n1 CHEMBL3609734 pIC50 6.607 nM
c1cnc(Nc2nc3c(s2)CCCc2n[nH]cc2-3)nc1 CHEMBL1830711 EC50 7.0 nM
COc1cc(NC(=O)c2cccc(F)n2)ccc1Cl CHEMBL3608323 IC50 7.3 nM
N#Cc1cc(NC(=O)c2ccccn2)ccc1F CHEMBL3609737 IC50 7.4 nM
FC(F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12 CHEMBL4779331 EC50 8.0 nM
c1ccc(Nc2nc3c(s2)CCCc2n[nH]cc2-3)nc1 CHEMBL1830707 EC50 9.0 nM
CC(=O)N1CCC(Oc2ccc3oc(-c4cc5cccn5cn4)c/c(=N\O)c3c2)CC1 CHEMBL4082573 EC50 10.0 nM
N#Cc1cccc(NC(=O)c2ccccn2)c1 CHEMBL3609736 IC50 10.4 nM
Cc1cccc2c1C(=O)N(c1ccc(NC(=O)c3ccccn3)cc1Cl)C2=O CHEMBL3357575 IC50 11.0 nM
Cc1cccc2c1C(=O)N(c1ccc(NC(=O)c3ccccn3)cc1Br)C2=O CHEMBL3357578 IC50 12.0 nM
Cc1sc(Nc2ccccn2)nc1-c1cn[nH]c1 CHEMBL1830694 EC50 13.0 nM
COc1cccc(NC(=O)c2ccccn2)c1 CHEMBL3609733 IC50 13.7 nM
O/N=c1\cc(-c2cc3sccc3cn2)oc2ccc(O[C@@H]3CCN(c4ccncn4)C3)cc12 CHEMBL4090015 EC50 17.0 nM
FC(F)(F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12 CHEMBL4763355 EC50 18.0 nM
Cc1cc(CCCOc2ccc3oc(-c4cc5cccn5cn4)c/c(=N\O)c3c2)ccn1 CHEMBL4092850 EC50 19.0 nM
O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2Cl)c(Cl)c1)c1ccccn1 CHEMBL1223381 EC50 19.8 nM
Cn1nc(C2CC2)c2ccc(Nc3n[nH]c4nccnc34)cc21 CHEMBL4247943 EC50 19.8 nM
Cc1noc2c(F)cc(Nc3n[nH]c4nccnc34)cc12 CHEMBL4467229 EC50 22.9 nM
Cn1nc(C2(C)CC2)c2ccc(Nc3n[nH]c4nccnc34)cc21 CHEMBL4247139 EC50 24.9 nM
O/N=c1\cc(-c2cc3sccc3cn2)oc2ccc(CCCN3CCC(F)(F)C3)cc12 CHEMBL4100168 EC50 25.0 nM
O=C(NC1CC(F)(F)C1)c1nsc2cc(Nc3n[nH]c4nccnc34)ccc12 CHEMBL4514040 EC50 26.0 nM
O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2Cl)cc1)c1ccccn1 CHEMBL1223083 EC50 27.0 nM
COc1cc(NC(=O)c2ccccn2)ccc1F CHEMBL551635 IC50 31.6 nM
Fc1cc(Cl)cc(Nc2n[nH]c3cccnc23)c1 CHEMBL3907930 EC50 32.0 nM
Fc1ccc(Nc2n[nH]c3cccnc23)cc1Cl CHEMBL3798040 EC50 33.0 nM
O/N=c1\cc(-c2cc3sccc3cn2)oc2ccc(OCCN3CCOCC3)cc12 CHEMBL4063474 EC50 35.0 nM
CN(C)C(=O)N1CC(Oc2ccc3oc(-c4cc5cccn5cn4)c/c(=N\O)c3c2)C1 CHEMBL4100586 EC50 35.0 nM
O=C(Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1)c1ccccn1 CHEMBL3357574 IC50 36.0 nM
CC(c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12)C(F)(F)F CHEMBL4781616 EC50 36.0 nM
[2H]C([2H])([2H])Cn1nc(C2CC2)c2ccc(Nc3n[nH]c4cccnc34)cc21 CHEMBL4241223 EC50 36.2 nM
CCc1nn(C)c2cc(Nc3n[nH]c4cccnc34)ccc12 CHEMBL4238452 EC50 37.9 nM
CCc1nsc2cc(Nc3n[nH]c4cccnc34)ccc12 CHEMBL4540386 pEC50 39.81 nM
O=C(Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)c(Cl)c1)c1ccccn1 CHEMBL1698378 EC50 41.9 nM
Clc1cc(Cl)cc(Nc2n[nH]c3cccnc23)c1 CHEMBL3958804 EC50 43.0 nM
Cn1nc(C2CC2)c2ccc(Nc3n[nH]c4cccnc34)cc21 CHEMBL4239430 EC50 43.0 nM
Cn1nc(C2CC2)c2ccc(Nc3n[nH]c4ncccc34)cc21 CHEMBL4241489 EC50 43.2 nM
O=C(Nc1ncc(S(=O)(=O)Cc2ccc(Cl)cc2F)s1)c1ccccn1 CHEMBL3809990 EC50 44.1 nM
CCc1nccc2cc(Nc3n[nH]c4cccnc34)ccc12 CHEMBL4756046 EC50 45.0 nM
Cn1nccc1-c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12 CHEMBL4740237 EC50 45.0 nM
Cn1nc(OC2CCOCC2)c2ccc(Nc3n[nH]c4cccnc34)cc21 CHEMBL4248273 EC50 45.4 nM
O/N=c1\cc(-c2cc3cccn3cn2)oc2ccc(OCCN3CCOCC3)cc12 CHEMBL4067875 EC50 46.0 nM
N#Cc1cc(NC(=O)c2ccccn2)ccc1Br CHEMBL3609739 pIC50 46.77 nM
Cc1nn(CC2CCC2)c2ccc(Nc3n[nH]c4cccnc34)cc12 CHEMBL4241532 EC50 46.8 nM
O=C(Nc1ncc(S(=O)(=O)Cc2ccc(Cl)cc2Cl)s1)c1ccccn1 CHEMBL3939625 EC50 49.9 nM
O/N=c1\cc(-c2cc3cc[nH]c3cn2)oc2ccccc12 CHEMBL4067271 EC50 50.0 nM
O/N=c1\cc(-c2cc3cccn3cn2)oc2ccc(OCCCc3cccnc3)cc12 CHEMBL4072094 EC50 50.0 nM
O=C(NC1CC(F)(F)C1)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12 CHEMBL4588443 EC50 50.1 nM
Cc1ccnc(Nc2nc3c(s2)CCCc2n[nH]cc2-3)n1 CHEMBL1830914 EC50 51.0 nM
FC(F)(F)c1nccc2cc(Nc3n[nH]c4nccnc34)ccc12 CHEMBL4784310 EC50 51.0 nM
Cc1cccc(Nc2n[nH]c3cccnc23)c1 CHEMBL3970896 EC50 51.4 nM
O=C(c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12)N1CCC(F)(F)CC1 CHEMBL4520127 EC50 52.4 nM
O/N=c1\cc(-c2cc3sccc3cn2)oc2ccc(NC3CCN(c4ccncn4)CC3)cc12 CHEMBL4061970 EC50 53.0 nM
CC(=O)N1CC(Oc2ccc3oc(-c4cc5sccc5cn4)c/c(=N\O)c3c2)C1 CHEMBL4081211 EC50 53.0 nM
Cc1n[nH]cc1-c1csc(Nc2ccccn2)n1 CHEMBL1830695 EC50 56.0 nM
O=C(Nc1ccc(N2C(=O)c3ccccc3C2=O)c(Cl)c1)c1ccccn1 CHEMBL1727966 EC50 59.4 nM
CN1CCCC12CCN(CCOc1ccc3oc(-c4cc5sccc5cn4)c/c(=N\O)c3c1)CC2 CHEMBL4067872 EC50 60.0 nM
Cc1ccc(S(=O)(=O)n2ccc(NC(=O)c3ccccn3)c2)cc1C CHEMBL3808555 pEC50 61.66 nM
c1cnc2c(Nc3ccc4c(-n5cccn5)nccc4c3)n[nH]c2c1 CHEMBL4787268 EC50 63.0 nM
FC(F)(F)c1nccc2cc(Nc3n[nH]c4ncccc34)ccc12 CHEMBL4797139 pEC50 64.57 nM
c1cnc(Nc2nc3c(s2)CCc2n[nH]cc2-3)nc1 CHEMBL1830702 EC50 65.0 nM
Cc1cc(N2C(=O)c3cccc(Cl)c3C2=O)c(F)cc1NC(=O)c1occc1C CHEMBL4798021 EC50 65.0 nM
c1cnc2c(Nc3ccc4c(C5CC5)nsc4c3)n[nH]c2n1 CHEMBL4461258 pEC50 67.61 nM
CN(C(=O)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12)C1CC(F)(F)C1 CHEMBL4536224 pEC50 67.61 nM
Cn1nc(C2(C)CC2)c2ccc(Nc3n[nH]c4cccnc34)cc21 CHEMBL4237497 EC50 67.9 nM
Cc1cc(Nc2n[nH]c3cccnc23)ccc1F CHEMBL3929112 EC50 68.0 nM
c1cnc2c(Nc3ccc4c(C5CC5)nccc4c3)n[nH]c2c1 CHEMBL4753304 EC50 71.0 nM
CC(C)(C)Cc1nsc2cc(Nc3n[nH]c4cccnc34)cnc12 CHEMBL4556685 EC50 74.0 nM
Cc1noc2ccc(Nc3n[nH]c4cccnc34)cc12 CHEMBL4522695 pEC50 75.86 nM
c1cnc2c(Nc3ccc4cnccc4c3)n[nH]c2c1 CHEMBL4783372 EC50 76.0 nM
O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2Cl)cc1)c1nccs1 CHEMBL1223312 EC50 77.4 nM
Cc1nn(C)c2cc(Nc3n[nH]c4cccnc34)ccc12 CHEMBL4250214 EC50 78.1 nM
O/N=c1\cc(-c2cc3sccc3cn2)oc2ccc(CCCN3CCOCC3)cc12 CHEMBL4089083 EC50 79.0 nM
c1cnc2c(Nc3ccc4c(C5CC5)nsc4c3)n[nH]c2c1 CHEMBL4513386 EC50 81.0 nM
FC1(F)CCN(Cc2nsc3cc(Nc4n[nH]c5cccnc45)cnc23)CC1 CHEMBL4483525 EC50 81.0 nM
O=C(Nc1ccn(S(=O)(=O)Cc2ccc(F)cc2Cl)c1)c1ccccn1 CHEMBL3809447 EC50 84.0 nM
Cn1nc(OCC2CCCCO2)c2ccc(Nc3n[nH]c4cccnc34)cc21 CHEMBL4249099 EC50 85.6 nM
Clc1cccc(Oc2ccc(Nc3n[nH]c4cccnc34)cc2Cl)n1 CHEMBL3891609 EC50 88.0 nM
CCc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1c(Cl)cccc1Cl CHEMBL3920531 EC50 88.0 nM
Cc1cc(N2C(=O)C3=C(CCCC3)C2=O)c(F)cc1NC(=O)c1ccco1 CHEMBL4760570 EC50 89.0 nM
COc1cc(NC(=O)c2cccc(F)n2)ccc1F CHEMBL3609735 pIC50 89.13 nM
O/N=c1\cc(-c2cc3sccc3cn2)oc2ccc(OCCN3CCC(F)(F)CC3)cc12 CHEMBL4085101 EC50 90.0 nM
N#Cc1ccc(Nc2n[nH]c3cccnc23)cc1Cl CHEMBL3946663 EC50 93.0 nM
Cc1ccc2c(c1)C(=O)N(c1cc(C)c(NC(=O)c3occc3C)cc1F)C2=O CHEMBL4777502 EC50 93.0 nM
CCn1nc(C)c2cc(Nc3n[nH]c4cccnc34)ccc21 CHEMBL4242608 EC50 95.1 nM
Cn1nc(CC(F)(F)F)c2ccc(Nc3n[nH]c4cccnc34)cc21 CHEMBL4245306 EC50 95.5 nM
CCC(CC)c1noc2cc(Nc3n[nH]c4nccnc34)ccc12 CHEMBL4584387 pEC50 97.72 nM
COc1cc(NC(=O)c2ccccn2)ccc1NC(=O)c1ccccc1Cl CHEMBL1672234 EC50 99.5 nM
COc1ccnc(Nc2nc3c(s2)CCCc2n[nH]cc2-3)n1 CHEMBL1830915 EC50 100.0 nM
N[C@@H](CCP(=O)(O)O)C(=O)O CHEMBL33567 EC50 100.0 nM
Fc1cc(F)cc(Nc2n[nH]c3cccnc23)c1 CHEMBL3927518 EC50 101.0 nM
CCc1nsc2cc(Nc3n[nH]c4ncccc34)ccc12 CHEMBL4575642 EC50 102.0 nM
O=C(Nc1ccc(N2S(=O)(=O)c3ccccc3S2(=O)=O)cc1)c1cscn1 CHEMBL1921952 EC50 104.0 nM
Cc1cccc(S(=O)(=O)n2ccc(NC(=O)c3ccccn3)c2)c1 CHEMBL3808963 EC50 104.0 nM
Cc1cc(COc2nn(C)c3cc(Nc4n[nH]c5cccnc45)ccc23)on1 CHEMBL4242783 EC50 104.0 nM
CC(C)(C)Cc1nsc2cc(Nc3n[nH]c4nccnc34)cnc12 CHEMBL4568302 pEC50 104.71 nM
Fc1cccc(Nc2nc3c(s2)CCCc2n[nH]cc2-3)n1 CHEMBL1830903 EC50 105.0 nM
O/N=c1\cc(-c2cc3sccc3cn2)oc2ccc(CCCN3CCC(F)(F)CC3)cc12 CHEMBL4082167 EC50 106.0 nM
Clc1cc(Nc2n[nH]c3cccnc23)ccc1Oc1cnccn1 CHEMBL3922380 EC50 108.0 nM
O=C(Nc1ccc(Oc2ccc(Cl)cn2)c(Cl)c1)c1ccccn1 CHEMBL4162576 EC50 108.0 nM
O/N=c1\cc(-c2cc3cccn3cn2)oc2ccccc12 CHEMBL4098106 EC50 110.0 nM
N[C@@H](CCP(=O)(O)C(O)c1ccc(OCC(=O)O)cc1)C(=O)O CHEMBL3114673 EC50 110.0 nM
Clc1cc(Nc2n[nH]c3cccnc23)ccc1Oc1ccccn1 CHEMBL3950346 EC50 112.0 nM
Clc1ccc(Nc2n[nH]c3cccnc23)cc1Cl CHEMBL3955855 EC50 113.0 nM
Cc1cc(N2C(=O)c3cccc(F)c3C2=O)c(F)cc1NC(=O)c1occc1C CHEMBL4764083 EC50 113.0 nM
O=C(Nc1ccc(NC(=O)c2ccc(F)cc2Cl)c(Cl)c1)c1ccccn1 CHEMBL1672245 EC50 114.0 nM
Fc1ccc(Cl)cc1Nc1n[nH]c2cccnc12 CHEMBL3959843 EC50 116.0 nM
Clc1cc(Nc2n[nH]c3cccnc23)ccc1Oc1ncccn1 CHEMBL3933898 EC50 116.0 nM
Cn1nc(C(=O)NC2CC(F)(F)C2)c2ccc(Nc3n[nH]c4cccnc34)cc21 CHEMBL4240579 EC50 116.0 nM
Cc1nnc2ccc(C(=O)NC3CN(c4cc(Cl)ncc4Cl)C3)cc2c1C CHEMBL4437035 EC50 116.0 nM
Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1c(Cl)cccc1Cl CHEMBL3984173 EC50 117.0 nM
CCCC(C)c1noc2cc(Nc3n[nH]c4ncccc34)ccc12 CHEMBL4465813 EC50 117.0 nM
Cn1nc(C(F)(F)F)c2ccc(Nc3n[nH]c4cccnc34)cc21 CHEMBL4246041 EC50 119.0 nM
COCCNc1nccc2cc(Nc3n[nH]c4cccnc34)ccc12 CHEMBL4797966 EC50 121.0 nM
O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2Cl)cc1)c1cccc(F)n1 CHEMBL1223241 EC50 122.0 nM
Cc1ccc(S(=O)(=O)n2ccc(NC(=O)c3ccccn3)c2)cc1 CHEMBL3808424 EC50 122.0 nM
Cc1noc2c(F)cc(Nc3n[nH]c4ncccc34)cc12 CHEMBL4582128 EC50 122.0 nM
Cc1cc(S(=O)(=O)n2cc(NC(=O)c3ccccn3)cn2)ccc1F CHEMBL3986803 EC50 124.0 nM
O=C(Nc1ccc(N2C(=O)c3ccccc3C2=O)c(Cl)c1)c1ncccc1O CHEMBL3800579 EC50 125.0 nM
O=C(Nc1cnn(S(=O)(=O)c2ccc(Cl)cc2F)c1)c1ccccn1 CHEMBL3957303 EC50 128.0 nM
Cc1cc(NC(=O)c2occc2C)c(F)cc1N1C(=O)c2ccccc2C1=O CHEMBL4745982 EC50 128.0 nM
CCC(CC)c1noc2cc(Nc3n[nH]c4cccnc34)ccc12 CHEMBL4552309 pEC50 128.82 nM
Cn1nc(C2(C)CC2)c2ccc(Nc3n[nH]c4ncccc34)cc21 CHEMBL4251433 EC50 129.0 nM
O/N=c1\cc(-c2cc3ccsc3cn2)oc2ccccc12 CHEMBL4097178 EC50 130.0 nM
COc1ccccc1NS(=O)(=O)c1ccc(NC(=O)c2ccccn2)cc1OC CHEMBL1223316 EC50 132.0 nM
Cn1nc(C(F)(F)F)cc1-c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12 CHEMBL4786373 EC50 132.0 nM
O=C(Nc1ccc(N2S(=O)(=O)c3ccccc3S2(=O)=O)cc1)c1ccccn1 CHEMBL1921855 EC50 136.0 nM
Cc1ccc(S(=O)(=O)n2cc(NC(=O)c3ccccn3)cn2)cc1F CHEMBL3943144 EC50 137.0 nM
Cc1noc2ccc(Nc3n[nH]c4nccnc34)cc12 CHEMBL4451827 EC50 137.0 nM
Clc1cccc(Nc2n[nH]c3cccnc23)c1 CHEMBL3907429 EC50 138.0 nM
O=C(Nc1cnn(S(=O)(=O)c2ccc(F)c(Cl)c2)c1)c1ccccn1 CHEMBL3945496 EC50 138.0 nM
CCc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1c(F)cccc1F CHEMBL3808861 EC50 139.0 nM
Cc1cccc(Nc2nc3c(s2)CCCc2n[nH]cc2-3)n1 CHEMBL1830900 EC50 140.0 nM
CCc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1c(F)cccc1Cl CHEMBL3892535 EC50 141.0 nM
Cc1ccc(S(=O)(=O)n2cc(NC(=O)c3ccccn3)cn2)cc1C CHEMBL3808486 EC50 144.0 nM
COc1cc(NC(=O)c2ccccn2)ccc1I CHEMBL3609732 pIC50 144.54 nM
FC(F)(F)c1cccc(Nc2n[nH]c3cccnc23)c1 CHEMBL3894951 EC50 145.0 nM
Fc1cc(Nc2n[nH]c3cccnc23)cc(F)c1F CHEMBL3937590 EC50 146.0 nM
O/N=c1\cc(-c2cc3cccn3cn2)oc2ccc(OCCN3CCC(F)(F)CC3)cc12 CHEMBL4098128 EC50 150.0 nM
N[C@@H](CCP(=O)(O)C(O)c1ccc([N+](=O)[O-])o1)C(=O)O CHEMBL4067923 EC50 150.0 nM
Fc1cc(Nc2n[nH]c3cccnc23)ccc1Oc1ccc(Cl)cn1 CHEMBL3952349 EC50 151.0 nM
Cc1cc(S(=O)(=O)n2cc(NC(=O)c3ccccn3)cn2)ccc1Cl CHEMBL3899605 EC50 151.0 nM
Fc1ccc(Nc2n[nH]c3nccnc23)cc1Cl CHEMBL3975540 EC50 156.0 nM
O=C(Nc1ccc(N2C(=O)CC3(CCCCC3)C2=O)c(Cl)c1)c1ccccn1 CHEMBL1705230 EC50 158.0 nM
Cc1cc(C)c(NS(=O)(=O)c2ccc(NC(=O)c3ccccn3)cc2)c(C)c1 CHEMBL1223014 EC50 159.0 nM
COCCOc1ccc2oc(-c3cc4cccn4cn3)c/c(=N\O)c2c1 CHEMBL4062968 EC50 160.0 nM
N[C@@H](CCP(=O)(O)C(O)c1csc([N+](=O)[O-])c1)C(=O)O CHEMBL4061423 EC50 160.0 nM
[2H]C([2H])([2H])Cn1nc(C2CC2)c2ccc(Nc3n[nH]c4ncccc34)cc21 CHEMBL4241662 EC50 160.0 nM
Cc1cc(S(=O)(=O)n2ccc(NC(=O)c3ccccn3)c2)ccc1Cl CHEMBL3808648 pEC50 162.18 nM
Cc1cccc(S(=O)(=O)n2cc(NC(=O)c3ccccn3)cn2)c1 CHEMBL3974101 EC50 163.0 nM
Cc1cc(Nc2n[nH]c3cccnc23)ccc1Cl CHEMBL3961520 EC50 164.0 nM
CCN(CC)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12 CHEMBL4754632 EC50 164.0 nM
Cc1ccc(Nc2n[nH]c3cccnc23)cc1Cl CHEMBL3900600 EC50 165.0 nM
CN(C)C1CCN(CCOc2ccc3oc(-c4cc5cccn5cn4)c/c(=N\O)c3c2)CC1 CHEMBL4062426 EC50 165.0 nM
COc1cccc(Nc2n[nH]c3cccnc23)c1 CHEMBL3937846 EC50 169.0 nM
N#Cc1cc(NC(=O)c2ccccn2)ccc1I CHEMBL3609740 pIC50 169.82 nM
COc1ccc(S(=O)(=O)n2cc(NC(=O)c3ccccn3)cn2)cc1 CHEMBL3914060 EC50 170.0 nM
O=C(Nc1ncc(S(=O)(=O)Cc2c(F)cccc2F)s1)c1ccccn1 CHEMBL3934074 EC50 170.0 nM
O=C(Nc1ccn(S(=O)(=O)Cc2ccccc2Cl)c1)c1ccccn1 CHEMBL3808951 pEC50 173.78 nM
Cc1nc(C(=O)Nc2cc(F)c(N3C(=O)C4=C(CCCC4)C3=O)cc2C)cs1 CHEMBL4795139 EC50 175.0 nM
O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1)c1ccccn1 CHEMBL1223015 EC50 177.0 nM
Cc1cc(C)cc(Nc2n[nH]c3cccnc23)c1 CHEMBL3976080 EC50 177.0 nM
O=C(Nc1ccc(N2S(=O)(=O)c3ccccc3S2(=O)=O)cc1)c1ccncn1 CHEMBL1921950 EC50 179.0 nM
O=C(Nc1nc(C(F)(F)F)c(S(=O)(=O)Cc2ccc(Cl)cc2F)s1)c1ccccn1 CHEMBL3975694 EC50 181.0 nM
Cc1ccoc1C(=O)Nc1cc(F)c(N2C(=O)c3cccc(Cl)c3C2=O)c(F)c1F CHEMBL4787053 EC50 187.0 nM
O=C(Nc1ccn(S(=O)(=O)Cc2ccc(C(F)(F)F)cc2)c1)c1ccccn1 CHEMBL3809765 EC50 188.0 nM
O=C(Nc1ncc(S(=O)(=O)Cc2ccccc2Cl)s1)c1ccccn1 CHEMBL3809341 EC50 189.0 nM
O=C(Oc1ccc2c(-c3cnn(-c4ccccc4)c3)ccnc2c1)N1CCCCC1 CHEMBL2023624 EC50 190.0 nM
O=C(Nc1ccn(S(=O)(=O)Cc2ccc(F)cc2F)c1)c1ccccn1 CHEMBL3809468 EC50 190.0 nM
Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1c(F)cccc1Cl CHEMBL3890158 EC50 192.0 nM
O=C(Nc1cnn(S(=O)(=O)c2cc(Cl)ccc2Cl)c1)c1ccccn1 CHEMBL3964592 EC50 197.0 nM
Cc1ccc2c(c1)C(=O)N(c1ccc(NC(=O)c3ncoc3C)cc1Cl)C2=O CHEMBL3758587 EC50 198.0 nM
CC(=O)N1CCC(c2nsc3cc(Nc4n[nH]c5cccnc45)ccc23)CC1 CHEMBL4591132 pEC50 199.53 nM
Cc1cnc(N)nc1/C=C/c1ccccc1 CHEMBL1209514 EC50 200.0 nM
O/N=c1\cc(-c2cc3sccc3cn2)oc2ccccc12 CHEMBL4079161 EC50 200.0 nM
O=C(Nc1cnn(S(=O)(=O)c2ccc(Cl)c(Cl)c2)c1)c1ccccn1 CHEMBL3902298 EC50 204.0 nM
O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2F)cc1)c1ccccn1 CHEMBL1223084 EC50 206.0 nM
Cc1ccoc1C(=O)Nc1c(F)cc(N2C(=O)c3ccccc3C2=O)c(F)c1F CHEMBL4799902 EC50 212.0 nM
c1cnc2c(Nc3ccc4c(N5CCCCC5)nccc4c3)n[nH]c2c1 CHEMBL4794816 EC50 215.0 nM
CCc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(Cl)cc1F CHEMBL3810375 EC50 217.0 nM
Oc1ccc(Nc2n[nH]c3cccnc23)cc1Cl CHEMBL3901833 EC50 217.0 nM
Fc1cc(Nc2n[nH]c3cccnc23)cc(C(F)(F)F)c1 CHEMBL3959958 EC50 217.0 nM
Cc1noc2ccc(Nc3n[nH]c4ncc(F)cc34)cc12 CHEMBL4475973 pEC50 218.78 nM
c1ccc(Nc2nc3c(s2)CCc2n[nH]cc2-3)nc1 CHEMBL1830698 EC50 220.0 nM
c1ccc(-n2cc(-c3ccnc4ccccc34)cn2)cc1 CHEMBL2022867 EC50 220.0 nM
COc1ccc2c(-c3cnn(-c4ccccc4)c3)ccnc2c1 CHEMBL2023457 EC50 220.0 nM
O=C(Nc1ccc(N2S(=O)(=O)c3ccccc3S2(=O)=O)cc1)c1ccco1 CHEMBL1921852 EC50 226.0 nM
Cc1noc2ccc(Nc3n[nH]c4ncccc34)cc12 CHEMBL4473211 EC50 227.0 nM
Cc1cc(N2C(=O)C3=C(CCCC3)C2=O)c(F)cc1NC(=O)c1ccc(Cl)o1 CHEMBL4797971 EC50 229.0 nM
CC(C)COc1nn(C)c2cc(Nc3n[nH]c4cccnc34)ccc12 CHEMBL4238603 EC50 231.0 nM
Cc1cccc(S(=O)(=O)n2cc(NC(=O)c3nccs3)cn2)c1 CHEMBL3913761 EC50 234.0 nM
O=C(Nc1cnn(S(=O)(=O)c2cc(F)c(F)c(F)c2)c1)c1ccccn1 CHEMBL3900841 EC50 234.0 nM
O=C(Nc1ccc(S(=O)(=O)Cc2ccccc2Cl)cc1)c1ccccn1 CHEMBL1223384 EC50 237.0 nM
Cc1ccn(-c2nccc3cc(Nc4n[nH]c5cccnc45)ccc23)n1 CHEMBL4782314 EC50 237.0 nM
O=C(Nc1cnn(S(=O)(=O)c2ccc(C(F)(F)F)cc2)c1)c1ccccn1 CHEMBL3810136 pEC50 239.88 nM
O/N=c1\cc(-c2cc3ncccc3cn2)oc2ccccc12 CHEMBL4071024 EC50 240.0 nM
CCc1ccc(S(=O)(=O)n2cc(NC(=O)c3ccccn3)cn2)cc1 CHEMBL3974630 EC50 248.0 nM
O=C(Nc1nc(C2CC2)c(S(=O)(=O)Cc2ccccc2F)s1)c1ccccn1 CHEMBL3970768 EC50 249.0 nM
FC1(F)CCN(c2nccc3cc(Nc4n[nH]c5cccnc45)ccc23)C1 CHEMBL4754007 EC50 249.0 nM
COCCCOc1ccc2c(-c3cnn(-c4ccccc4)c3)ccnc2c1 CHEMBL2023462 EC50 250.0 nM
O=C(Nc1ccn(S(=O)(=O)Cc2ccccc2F)c1)c1ccccn1 CHEMBL3809364 EC50 251.0 nM
FC(F)Oc1cccc(Nc2n[nH]c3cccnc23)c1 CHEMBL3952838 EC50 254.0 nM
Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(Cl)cc1F CHEMBL3809402 EC50 255.0 nM
Cn1ncc2ccc(Nc3n[nH]c4cccnc34)cc21 CHEMBL4239399 EC50 257.0 nM
COc1ccc(S(=O)(=O)n2cc(NC(=O)c3ccccn3)cn2)cc1Cl CHEMBL3943225 EC50 260.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)c(F)c1 CHEMBL3634420 EC50 264.0 nM
O=c1[nH]ccc2cc(Nc3n[nH]c4cccnc34)ccc12 CHEMBL4784617 EC50 264.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(F)c1 CHEMBL3634418 EC50 265.0 nM
Cc1nn(C2CCCC2)c2ccc(Nc3n[nH]c4cccnc34)cc12 CHEMBL4249560 EC50 265.0 nM
Cc1cc(N2C(=O)C3=C(CCCC3)C2=O)c(F)cc1NC(=O)c1occc1C CHEMBL4792152 EC50 266.0 nM
Cc1ccoc1C(=O)Nc1cc(F)c(N2C(=O)c3cccc(F)c3C2=O)c(F)c1F CHEMBL4746530 EC50 267.0 nM
Cc1cc(S(=O)(=O)n2ccc(NC(=O)c3ccccn3)c2)ccc1F CHEMBL3809272 EC50 268.0 nM
O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2Cl)cc1)c1ccsc1 CHEMBL1223313 EC50 269.0 nM
CC(C)(C)Cc1nsc2cc(Nc3n[nH]c4cccnc34)ccc12 CHEMBL4456258 EC50 269.0 nM
O=C(Nc1nc(C(F)(F)F)c(S(=O)(=O)Cc2ccccc2Cl)s1)c1ccccn1 CHEMBL3986822 EC50 271.0 nM
Cc1noc2c(F)cc(Nc3n[nH]c4cccnc34)cc12 CHEMBL4459205 EC50 274.0 nM
O=C(c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12)N1CCOCC1 CHEMBL4445465 EC50 275.0 nM
O/N=c1\cc(-c2cn3cccc3cn2)oc2ccccc12 CHEMBL4089473 EC50 280.0 nM
COc1ccc(Nc2n[nH]c3cccnc23)cc1Cl CHEMBL3908181 EC50 282.0 nM
O=C(Nc1cnn(S(=O)(=O)c2ccc(F)c(F)c2F)c1)c1ccccn1 CHEMBL3963484 EC50 282.0 nM
Clc1ccnc(Nc2n[nH]c3cccnc23)c1 CHEMBL3969118 EC50 284.0 nM
O=C(Nc1ccc(N2C(=O)[C@@H]3[C@H](C2=O)[C@H]2C=C[C@@H]3CC2)c(Cl)c1)c1ccccn1 CHEMBL1921962 EC50 287.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)c(F)c1 CHEMBL3634419 EC50 287.0 nM
Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(Cl)cc1Cl CHEMBL3931820 EC50 289.0 nM
Cn1nc(C(=O)N2CCC(F)(F)C2)c2ccc(Nc3n[nH]c4cccnc34)cc21 CHEMBL4241027 EC50 289.0 nM
CCOc1cccc(Nc2nc3c(s2)CCCc2n[nH]cc2-3)n1 CHEMBL1830906 EC50 290.0 nM
O=C(Nc1ccc(N2C(=O)[C@@H]3[C@H](C2=O)[C@@H]2C=C[C@H]3C2)c(Cl)c1)c1ccccn1 CHEMBL1921961 EC50 291.0 nM
O=C(Nc1ccc(N2C(=O)C3C(C2=O)[C@H]2C=C[C@@H]3C2)c(Cl)c1)c1ccccn1 CHEMBL3609730 EC50 291.0 nM
Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1c(F)cccc1F CHEMBL3810148 EC50 295.0 nM
CCc1cnc(Oc2ccc(NC(=O)c3nccnc3N)cc2Cl)nc1 CHEMBL3799284 EC50 296.0 nM
Cc1nnc2ccc(C(=O)NC3CN(c4ncc(C#N)cc4Cl)C3)cc2c1C CHEMBL4561636 EC50 304.0 nM
Cc1scnc1C(=O)Nc1ccc(N2C(=O)c3ccc(F)cc3C2=O)c(Cl)c1 CHEMBL3758967 EC50 306.0 nM
FC(F)(F)C1CCCCN1c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12 CHEMBL4744787 EC50 306.0 nM
O/N=c1\cc(-c2cc3ccccc3cn2)oc2ccccc12 CHEMBL4081595 EC50 310.0 nM
O=C(c1ccccc1F)c1ccc(Nc2n[nH]c3cccnc23)cc1Cl CHEMBL3973565 EC50 311.0 nM
Fc1ccc2[nH]nc(Nc3ccc(F)c(Cl)c3)c2n1 CHEMBL3947471 EC50 312.0 nM
Cc1ccc(F)c(Nc2n[nH]c3cccnc23)c1 CHEMBL3930906 EC50 314.0 nM
CC(C)c1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1c(F)cccc1F CHEMBL3935314 EC50 316.0 nM
N[C@@H](CCP(=O)(O)[C@@H](O)c1cccc([N+](=O)[O-])c1)C(=O)O CHEMBL4085750 EC50 320.0 nM
COc1cc(NC(=O)c2ccccn2)ccc1Br CHEMBL3609731 IC50 322.0 nM
Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1cc(F)c(F)cc1F CHEMBL3927279 EC50 322.0 nM
Cc1ccc2c(c1)C(=O)N(c1ccc(NC(=O)c3occc3C)cc1Cl)C2=O CHEMBL3628110 EC50 323.0 nM
CC(C)(C)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12 CHEMBL4449390 pEC50 323.59 nM
CC1CN(C(=O)c2nsc3cc(Nc4n[nH]c5cccnc45)ccc23)CC(C)O1 CHEMBL4518186 pEC50 323.59 nM
Cc1ccc(S(=O)(=O)n2cc(NC(=O)c3nccs3)cn2)cc1 CHEMBL3930733 EC50 324.0 nM
O=C(Nc1ccc(S(=O)(=O)Nc2cc(F)ccc2F)cc1)c1ccccn1 CHEMBL1223085 EC50 325.0 nM
NC(CCP(=O)(O)O)C(=O)O CHEMBL285843 EC50 330.0 nM
O=C(c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12)N1CCC(F)(F)C1 CHEMBL4518731 EC50 331.0 nM
CN(C)c1cccc(Nc2nc3c(s2)CCCc2n[nH]cc2-3)n1 CHEMBL1830911 EC50 340.0 nM
Fc1cc(F)c(Nc2n[nH]c3cccnc23)cc1Cl CHEMBL3983978 EC50 342.0 nM
O=C(Nc1ccn(S(=O)(=O)c2ccc(Cl)cn2)c1)c1ccccn1 CHEMBL3808889 EC50 344.0 nM
Cc1nn(C)c2ccc(Nc3n[nH]c4cccnc34)cc12 CHEMBL4249753 EC50 345.0 nM
Oc1ccc(Nc2n[nH]c3cccnc23)cc1F CHEMBL3944839 EC50 349.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)cc1 CHEMBL3634415 EC50 350.0 nM
O=C(c1ccccc1)c1ccc(Nc2n[nH]c3cccnc23)cc1Cl CHEMBL3901929 EC50 351.0 nM
O=C(Nc1ccc(N2S(=O)(=O)c3ccccc3S2(=O)=O)cc1)c1nccs1 CHEMBL1921951 EC50 353.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c2ccccc12 CHEMBL3634441 EC50 353.0 nM
Clc1cncc(Nc2n[nH]c3cccnc23)c1 CHEMBL3968018 EC50 353.0 nM
CCc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1c(C)cc(C)cc1C CHEMBL3913983 EC50 354.0 nM
O=C(Nc1ccc(NC(=O)c2ccccn2)cc1Cl)c1ccccc1 CHEMBL1672244 EC50 361.0 nM
O=C(Nc1ccc(N2C(=O)[C@H]3CCCC[C@H]3C2=O)c(Cl)c1)c1ccccn1 CHEMBL1921959 EC50 370.0 nM
CC1CCN(S(=O)(=O)c2ccc(NC(=O)c3ccccn3)cc2)CC1 CHEMBL1223164 EC50 372.0 nM
COc1cc(N2CC(NC(=O)c3ccc4nnc(C)c(C)c4c3)C2)c(Cl)cn1 CHEMBL4583516 EC50 373.0 nM
O=C(Nc1ccccn1)[C@]12C[C@H]1/C(=N\O)c1ccccc1O2 CHEMBL2063423 EC50 380.0 nM
N[C@@H](CCP(=O)(O)C(O)c1ccc([N+](=O)[O-])cc1)C(=O)O CHEMBL4088782 EC50 380.0 nM
N[C@@H](CCP(=O)(O)C(O)c1ccc(C(F)(F)F)c([N+](=O)[O-])c1)C(=O)O CHEMBL4063142 EC50 380.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)cc1 CHEMBL3634417 EC50 382.0 nM
Fc1ccc(Nc2n[nH]c3cccnc23)cc1C(F)(F)F CHEMBL3984897 EC50 385.0 nM
O=C(C1CC1)N1CCC(c2nsc3cc(Nc4n[nH]c5cccnc45)ccc23)CC1 CHEMBL4569169 EC50 389.0 nM
COCCOc1cccc(Nc2nc3c(s2)CCCc2n[nH]cc2-3)n1 CHEMBL1830910 EC50 390.0 nM
COCCOc1ccc2c(-c3cnn(-c4ccccc4)c3)ccnc2c1 CHEMBL2023461 EC50 390.0 nM
CCN(CC)C(=O)Oc1ccc2c(-c3cnn(-c4ccccc4)c3)ccnc2c1 CHEMBL2023623 EC50 390.0 nM
O=C(Nc1ccn(S(=O)(=O)Cc2ccc(Cl)cc2)c1)c1ccccn1 CHEMBL3808534 EC50 398.0 nM
O=C(Nc1ncc(S(=O)(=O)Cc2ccccc2F)s1)c1ccccn1 CHEMBL3911644 EC50 398.0 nM
CC1CCN(C(=O)c2nsc3cc(Nc4n[nH]c5cccnc45)ccc23)CC1 CHEMBL4452606 EC50 398.0 nM
N[C@@H](CCP(=O)(O)C(O)c1ccc([N+](=O)[O-])c(C(F)(F)F)c1)C(=O)O CHEMBL4078629 EC50 400.0 nM
O=C(Nc1nc(C(F)(F)F)c(S(=O)(=O)Cc2ccccc2F)s1)c1ccccn1 CHEMBL3958116 EC50 401.0 nM
O=C(Nc1ccc(N2S(=O)(=O)c3ccccc3S2(=O)=O)cc1)c1ccccc1 CHEMBL1921853 EC50 402.0 nM
O=C(Nc1ccc(NC(=O)c2nccs2)c(Cl)c1)c1ccccn1 CHEMBL1909434 EC50 403.0 nM
c1ccc2cc(Nc3n[nH]c4cccnc34)ccc2c1 CHEMBL4763214 EC50 403.0 nM
Cc1ocnc1C(=O)Nc1ccc(N2C(=O)c3ccc(Cl)cc3C2=O)c(Cl)c1 CHEMBL3759289 EC50 405.0 nM
c1ccc(Nc2nc(-c3cn[nH]c3)cs2)nc1 CHEMBL1830693 EC50 410.0 nM
Fc1c(Cl)cc(Nc2n[nH]c3cccnc23)cc1Cl CHEMBL3977207 EC50 410.0 nM
Cc1ccc(Cl)cc1Nc1n[nH]c2cccnc12 CHEMBL3914154 EC50 410.0 nM
CC(C)Oc1nn(C)c2cc(Nc3n[nH]c4cccnc34)ccc12 CHEMBL4245763 EC50 413.0 nM
N[C@@H](CCP(=O)(O)Cc1cccc([N+](=O)[O-])c1)C(=O)O CHEMBL4064187 EC50 420.0 nM
Cc1cc(NC(=O)c2occc2C)ccc1N1C(=O)c2cccc(C)c2C1=O CHEMBL3634423 EC50 422.0 nM
O=C(Nc1ccc(NC(=O)C2CCCCC2)c(Cl)c1)c1ccccn1 CHEMBL1672243 EC50 426.0 nM
Clc1cc(Nc2n[nH]c3cccnc23)ccc1OCc1ccccc1 CHEMBL3935108 EC50 426.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)c2ccccc12 CHEMBL3634442 EC50 429.0 nM
CC1(C)[C@@H]2C(=O)N(c3ccc(NC(=O)c4ccccn4)cc3Cl)C(=O)[C@@H]21 CHEMBL1711049 EC50 435.0 nM
O=C(Nc1ccn(S(=O)(=O)c2ccc(Cl)nc2)c1)c1ccccn1 CHEMBL3809795 pEC50 436.52 nM
N[C@@H](CCP(=O)(O)C(O)c1ccc(F)c([N+](=O)[O-])c1)C(=O)O CHEMBL4091029 EC50 440.0 nM
Cc1ccc(CS(=O)(=O)c2sc(NC(=O)c3ccccn3)nc2C)cc1 CHEMBL3921043 EC50 445.0 nM
Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccccc1Cl CHEMBL3808634 pEC50 446.68 nM
CC1CC(C)CN(C(=O)c2nsc3cc(Nc4n[nH]c5cccnc45)ccc23)C1 CHEMBL4584171 pEC50 446.68 nM
CCc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(C)cc1 CHEMBL3941960 EC50 450.0 nM
c1cnc2c(Nc3ccc4c(C5CC5)n[nH]c4c3)n[nH]c2c1 CHEMBL4242079 EC50 452.0 nM
O=C(Nc1nc(CF)c(S(=O)(=O)Cc2c(F)cccc2F)s1)c1ccccn1 CHEMBL3956107 EC50 463.0 nM
Cc1nnc2ccc(C(=O)NC3CN(c4ncc(F)cc4Cl)C3)cc2c1C CHEMBL4445506 EC50 464.0 nM
Cn1nc(C2CC2)c2ncc(Nc3n[nH]c4cccnc34)cc21 CHEMBL4245399 EC50 468.0 nM
Cc1scnc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1 CHEMBL3759171 EC50 474.0 nM
O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2Cl)cc1)c1ccncn1 CHEMBL1223243 EC50 478.0 nM
Cc1nn(-c2ccccc2)cc1-c1ccnc2ccccc12 CHEMBL2023451 EC50 480.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)cc1 CHEMBL3634416 EC50 483.0 nM
Cc1ccc(S(=O)(=O)n2cc(NC(=O)c3ccccn3)cn2)c(C)c1 CHEMBL3915259 EC50 486.0 nM
Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(Cl)cc1 CHEMBL3910418 EC50 486.0 nM
CCc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1cccc(Cl)c1F CHEMBL3969803 EC50 488.0 nM
N[C@@H](CCP(=O)(O)C(O)c1ccc([N+](=O)[O-])s1)C(=O)O CHEMBL4090179 EC50 490.0 nM
Fc1cc(Nc2n[nH]c3cccnc23)ccc1Oc1cc(C(F)(F)F)ccn1 CHEMBL3942548 EC50 497.0 nM
O=C(Nc1nc(C(F)(F)F)c(S(=O)(=O)Cc2ccc(Cl)cc2Cl)s1)c1ccccn1 CHEMBL3961434 EC50 497.0 nM
Cn1nc(C(=O)N2CCC(F)(F)CC2)c2ccc(Nc3n[nH]c4cccnc34)cc21 CHEMBL4248576 EC50 498.0 nM
O=C(Oc1ccc2c(-c3cnn(-c4ccccc4)c3)ccnc2c1)N1CCCC1 CHEMBL2023625 EC50 500.0 nM
N[C@@H](CCP(=O)(O)[C@H](O)c1ccc(O)c([N+](=O)[O-])c1)C(=O)O CHEMBL4072316 EC50 500.0 nM
Cc1cccc2c1C(=O)N(c1ccc(NC(=O)c3nccn3C)cc1Cl)C2=O CHEMBL3758228 EC50 506.0 nM
c1cnc2c(Nc3ccc4c(C5CCCC5)noc4c3)n[nH]c2n1 CHEMBL4454698 pEC50 512.86 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)c2ccccc12 CHEMBL3634443 EC50 513.0 nM
O=C(Nc1ccc(NC(=O)c2ccccc2Cl)c(Cl)c1)c1ccccn1 CHEMBL1672238 EC50 517.0 nM
Cc1cccc2c1C(=O)N(c1ccc(NC(=O)c3ncoc3C)cc1Cl)C2=O CHEMBL3759424 EC50 519.0 nM
CCC(CC)c1noc2cc(Nc3n[nH]c4ncccc34)ccc12 CHEMBL4570505 pEC50 524.81 nM
Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1cccc(Cl)c1F CHEMBL3959217 EC50 535.0 nM
CCOc1ccc2c(-c3cnn(-c4ccccc4)c3)ccnc2c1 CHEMBL2023459 EC50 540.0 nM
N[C@@H](CCP(=O)(O)C(O)c1cccc([N+](=O)[O-])c1)C(=O)O CHEMBL4093492 EC50 540.0 nM
NC(c1cccc([N+](=O)[O-])c1)P(=O)(O)CC[C@H](N)C(=O)O CHEMBL4072409 EC50 540.0 nM
Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(F)cc1F CHEMBL3810046 EC50 547.0 nM
FC(F)(F)c1ccc2c(-c3cnn(-c4ccccc4)c3)ccnc2c1 CHEMBL2023455 EC50 550.0 nM
O=C(Nc1ccc(NC(=O)c2ccccc2Cl)c(F)c1)c1ccccn1 CHEMBL1672241 EC50 556.0 nM
COc1cc(NC(=O)c2ccccn2)ccc1C CHEMBL561835 EC50 560.0 nM
O=C(Nc1ccn(S(=O)(=O)Cc2cccc(F)c2)c1)c1ccccn1 CHEMBL3809562 EC50 572.0 nM
CC(C)c1noc2cc(Nc3n[nH]c4cccnc34)ccc12 CHEMBL4551081 EC50 575.0 nM
Nc1cccnc1C(=O)Nc1cccc(Cl)c1 CHEMBL3797449 pEC50 575.44 nM
N[C@]1(C(=O)O)C[C@@H]1CP(=O)(O)O CHEMBL34880 EC50 580.0 nM
NC1(C(=O)O)CC1CP(=O)(O)O CHEMBL440648 EC50 580.0 nM
Fc1cccc(Nc2n[nH]c3cccnc23)c1 CHEMBL3897174 EC50 584.0 nM
Clc1ccc2c(-c3cnn(-c4ccccc4)c3)ccnc2c1 CHEMBL2023456 EC50 590.0 nM
Fc1ncc(Cl)cc1Nc1n[nH]c2cccnc12 CHEMBL3977654 EC50 597.0 nM
Nc1nc(/C=C/c2ccccc2)cc(C(F)(F)F)n1 CHEMBL1209519 EC50 600.0 nM
CCNc1cccc(Nc2nc3c(s2)CCCc2n[nH]cc2-3)n1 CHEMBL1830912 EC50 600.0 nM
Cc1ccc2c(c1)C(=O)N(c1ccc(NC(=O)c3nccn3C)cc1Cl)C2=O CHEMBL3759555 EC50 602.0 nM
Cc1cc(N2C(=O)c3ccccc3C2=O)ccc1NC(=O)c1occc1C CHEMBL3634447 EC50 609.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)c(Cl)c1 CHEMBL3628109 pEC50 616.6 nM
Fc1c(Cl)cccc1Nc1n[nH]c2cccnc12 CHEMBL3932339 EC50 623.0 nM
COc1cc(NC(=O)c2nccs2)ccc1NC(=O)c1ccccc1Cl CHEMBL1672232 EC50 627.0 nM
c1ccc(COc2ccc3c(-c4cnn(-c5ccccc5)c4)ccnc3c2)cc1 CHEMBL2023460 EC50 640.0 nM
Cc1ocnc1C(=O)Nc1ccc(N2C(=O)c3ccc(F)cc3C2=O)c(Cl)c1 CHEMBL3759381 EC50 642.0 nM
Fc1ccc(Nc2n[nH]c3cccnc23)cc1F CHEMBL3919518 EC50 644.0 nM
COc1cc(NC(=O)c2occc2C)ccc1N1C(=O)c2cccc(Cl)c2C1=O CHEMBL3632642 EC50 647.0 nM
Cc1nnc2ccc(C(=O)NC3CN(c4ncc(Cl)cc4F)C3)cc2c1C CHEMBL4436022 EC50 648.0 nM
COc1cccc(Nc2nc3c(s2)CCCc2n[nH]cc2-3)n1 CHEMBL1830905 EC50 650.0 nM
Cc1ccc(S(=O)(=O)n2cc(NC(=O)c3nccs3)cn2)cc1C CHEMBL3914010 EC50 652.0 nM
Cn1nc(C(=O)NC2CCC2)c2ccc(Nc3n[nH]c4cccnc34)cc21 CHEMBL4249226 EC50 653.0 nM
O=c1c2ccc(Nc3n[nH]c4cccnc34)cc2ccn1CC1CCC1 CHEMBL4755785 EC50 653.0 nM
Cc1nnc2ccc(C(=O)NC3CN(c4cccc(F)n4)C3)cc2c1C CHEMBL4522845 EC50 668.0 nM
Cc1c(-c2ccnc3ccccc23)cnn1-c1ccccc1 CHEMBL2023452 EC50 670.0 nM
O=C(Nc1ccc(N2C(=O)CC(c3ccccc3)C2=O)c(Cl)c1)c1ccccn1 CHEMBL1698322 EC50 674.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(F)c1 CHEMBL3634421 EC50 674.0 nM
CC(F)(F)c1noc2cc(Nc3n[nH]c4cccnc34)ccc12 CHEMBL4468073 pEC50 676.08 nM
O=C(Nc1nc(C(F)F)c(S(=O)(=O)Cc2c(F)cccc2F)s1)c1ccccn1 CHEMBL3925341 EC50 683.0 nM
CC(C)Cn1ccc2cc(Nc3n[nH]c4cccnc34)ccc2c1=O CHEMBL4762098 EC50 685.0 nM
CN(c1ccccc1Cl)S(=O)(=O)c1ccc(NC(=O)c2nccs2)cc1 CHEMBL1223315 EC50 686.0 nM
CC(=O)N1CCN(CCOc2ccc3c(-c4cnn(-c5ccccc5)c4)ccnc3c2)CC1 CHEMBL2023471 EC50 690.0 nM
O/N=c1\cc(-c2cc3ccccc3cn2)oc2ccc(Br)cc12 CHEMBL4096136 EC50 690.0 nM
c1cnc2c(Nc3ccc4c(C5CCC5)noc4c3)n[nH]c2n1 CHEMBL4440167 pEC50 707.95 nM
Cc1ccccc1CS(=O)(=O)c1sc(NC(=O)c2ccccn2)nc1C CHEMBL3893029 EC50 709.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(F)cc3C2=O)c(Cl)c1 CHEMBL3628114 EC50 712.0 nM
N[C@@]1(C(=O)O)C[C@H]1CP(=O)(O)O CHEMBL229697 EC50 720.0 nM
COc1cc([C@@H](O)P(=O)(O)CC[C@H](N)C(=O)O)cc([N+](=O)[O-])c1O CHEMBL4081842 EC50 720.0 nM
Clc1cc(Nc2n[nH]c3cccnc23)cc(Cl)c1Cl CHEMBL3906552 EC50 721.0 nM
c1cnc2c(Nc3ccc4c(C5CCCC5)noc4c3)n[nH]c2c1 CHEMBL4437680 EC50 723.0 nM
Cc1cc(C)n(-c2nccc3cc(Nc4n[nH]c5cccnc45)ccc23)n1 CHEMBL4785728 EC50 726.0 nM
Fc1ccc2c(-c3cnn(-c4ccccc4)c3)ccnc2c1 CHEMBL2023454 EC50 730.0 nM
O=C(Nc1ccc(Cl)c(S(=O)(=O)Nc2ccccc2Cl)c1)c1ccccn1 CHEMBL1223383 EC50 731.0 nM
c1cnc2ccc(Nc3n[nH]c4cccnc34)cc2c1 CHEMBL4788007 EC50 732.0 nM
Cc1nnc2ccc(C(=O)NC3CN(c4ccc(F)c(F)c4)C3)cc2c1C CHEMBL4475472 EC50 737.0 nM
O=C(Nc1ccn(S(=O)(=O)c2ccc(C(F)(F)F)cc2)c1)c1ccccn1 CHEMBL3809183 EC50 739.0 nM
O=C(Nc1cc(Cl)cc(Cl)c1)[C@H]1CCCC[C@H]1C(=O)O CHEMBL578988 EC50 740.0 nM
O=C(Nc1ccn(S(=O)(=O)c2ccc(F)cc2)c1)c1ccccn1 CHEMBL3809928 EC50 740.0 nM
Fc1ccc(Nc2nc3c(s2)CCCc2n[nH]cc2-3)nc1 CHEMBL1830902 EC50 750.0 nM
COCCOc1ccc2oc(-c3cc4ccccc4cn3)c/c(=N\O)c2c1 CHEMBL4064041 EC50 750.0 nM
CN1C(=O)N(c2ccc(Nc3n[nH]c4cccnc34)cc2Cl)C(=O)C1C(C)(C)C CHEMBL3907055 EC50 753.0 nM
CC(C)(C)Cc1nsc2cc(Nc3n[nH]c4ncccc34)ccc12 CHEMBL4568745 pEC50 758.58 nM
Cn1nc(C(=O)N2CC[C@H](F)C2)c2ccc(Nc3n[nH]c4cccnc34)cc21 CHEMBL4237293 EC50 764.0 nM
O=C(Nc1ccc(N2S(=O)(=O)c3ccccc3S2(=O)=O)cc1)C1CCCCC1 CHEMBL1921854 EC50 765.0 nM
CC1(c2ccccc2)CC(=O)N(c2ccc(NC(=O)c3ccccn3)cc2Cl)C1=O CHEMBL1699345 EC50 771.0 nM
Fc1cc(F)c(F)c(Nc2n[nH]c3cccnc23)c1 CHEMBL3937959 EC50 782.0 nM
Cn1nc(C(=O)NC2CC(F)C2)c2ccc(Nc3n[nH]c4cccnc34)cc21 CHEMBL4240046 EC50 794.0 nM
FC(F)(F)c1nsc2cc(Nc3n[nH]c4ncccc34)ccc12 CHEMBL4582180 EC50 794.0 nM
Cc1cc(/C=C/c2ccccc2)nc(N)n1 CHEMBL1209438 EC50 800.0 nM
NC(c1csc([N+](=O)[O-])c1)P(=O)(O)CC[C@H](N)C(=O)O CHEMBL4075877 EC50 800.0 nM
Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c2ccccc12 CHEMBL3634444 EC50 809.0 nM
CC(C)Cc1noc2cc(Nc3n[nH]c4cccnc34)ccc12 CHEMBL4475516 pEC50 812.83 nM
CCn1nc(Cl)c2cc(Nc3n[nH]c4cccnc34)ccc21 CHEMBL4239644 EC50 815.0 nM
Cn1nc(C(=O)N2CCCC2)c2ccc(Nc3n[nH]c4cccnc34)cc21 CHEMBL4248724 EC50 827.0 nM
Cc1nn(-c2ccccc2)c(C)c1-c1ccnc2ccccc12 CHEMBL2023453 EC50 840.0 nM
COc1cc(NC(=O)c2cscn2)ccc1NC(=O)c1ccccc1Cl CHEMBL1672233 EC50 845.0 nM
c1cnc2c(Nc3ccc4c(C5CCC5)noc4c3)n[nH]c2c1 CHEMBL4442185 EC50 851.0 nM
CC(C)(C)Cc1noc2cc(Nc3n[nH]c4nccnc34)ccc12 CHEMBL4436346 pEC50 851.14 nM
Cn1ccc2cc(-c3c/c(=N\O)c4ccccc4o3)ncc21 CHEMBL4068295 EC50 860.0 nM
c1cnc2c(Nc3ccc4c(NC5CCC5)nccc4c3)n[nH]c2c1 CHEMBL4761011 EC50 869.0 nM
Cn1ncc2cc(Nc3n[nH]c4cccnc34)ccc21 CHEMBL4243630 EC50 870.0 nM
COc1cc(NC(=O)c2occc2C)ccc1N1C(=O)c2cccc(C)c2C1=O CHEMBL3634431 EC50 882.0 nM
Cc1cc(NC(=O)c2occc2C)ccc1N1C(=O)c2ccccc2C1=O CHEMBL3634422 EC50 885.0 nM
COc1ccc(Nc2n[nH]c3cccnc23)cc1OC(F)F CHEMBL3951739 EC50 885.0 nM
O=C(Oc1ccc2c(-c3cnn(-c4ccccc4)c3)ccnc2c1)N1CCOCC1 CHEMBL2023626 EC50 900.0 nM
N[C@@H](CCP(=O)(O)C(O)c1cc([N+](=O)[O-])ccc1O)C(=O)O CHEMBL4101745 EC50 900.0 nM
COc1cc(C(O)P(=O)(O)CC[C@H](N)C(=O)O)cc([N+](=O)[O-])c1O CHEMBL3114672 EC50 900.0 nM
Cn1nc(C(=O)N2CC[C@@H](F)C2)c2ccc(Nc3n[nH]c4cccnc34)cc21 CHEMBL4247308 EC50 907.0 nM
Cc1cccc(Nc2nc3c(s2)CCc2n[nH]cc2-3)n1 CHEMBL1830705 EC50 910.0 nM
Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(F)c(F)c1 CHEMBL3930344 EC50 937.0 nM
CCc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(Cl)cc1Cl CHEMBL3895941 EC50 939.0 nM
NC(=O)[C@@H]1CCCC[C@@H]1C(=O)Nc1cc(Cl)cc(Cl)c1 CHEMBL578358 EC50 950.0 nM
CN(C)C(=O)Oc1ccc2c(-c3cnn(-c4ccccc4)c3)ccnc2c1 CHEMBL2023622 EC50 950.0 nM
Cc1nnc2ccc(C(=O)NC3CN(c4ncccc4Cl)C3)cc2c1C CHEMBL4450773 EC50 952.0 nM
Cc1ccccc1C(=O)Nc1ccc(NC(=O)c2ccccn2)cc1Cl CHEMBL1672242 EC50 958.0 nM
c1ccc2ncc(Nc3n[nH]c4cccnc34)cc2c1 CHEMBL3915530 EC50 961.0 nM
COc1cc(NC(=O)c2ccco2)ccc1NC(=O)c1ccccc1Cl CHEMBL1385271 EC50 977.0 nM
Cc1ccc2oc(-c3cc4ccccc4cn3)c/c(=N\O)c2c1 CHEMBL4067152 EC50 980.0 nM
Cc1ocnc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)c(Cl)c1 CHEMBL3759867 EC50 983.0 nM
CN(c1ccccc1Cl)S(=O)(=O)c1ccc(NC(=O)c2ccncn2)cc1 CHEMBL1223314 EC50 990.0 nM