O=C1N[C@H](c2cncc(C#Cc3ccccc3)c2)[C@@H](c2ccc(F)c(F)c2)O1 CHEMBL4550190 EC50 0.2 nM
Cc1ccc([N+](=O)[O-])c(N2CCC(=CC#Cc3ccc(C#N)cn3)CC2)n1 CHEMBL3597600 Ki 0.3 nM
Cc1cccc(C#CC=C2CCN(c3ncccc3[N+](=O)[O-])CC2)c1 CHEMBL3597597 Ki 0.3 nM
Cc1cccc(C#CC=C2CCN(c3ccccc3[N+](=O)[O-])CC2)n1 CHEMBL3597596 Ki 0.3 nM
O=[N+]([O-])c1cccnc1N1CCC(=CC#Cc2ccccn2)CC1 CHEMBL3597593 Ki 0.3 nM
Cc1cccc(C(=O)N[C@@]23CCC[C@@](NC(=O)c4ccccn4)(CC2)C3)n1 CHEMBL4111384 IC50 0.32 nM
Cc1nc(C#Cc2cccc(C#N)c2)cs1 CHEMBL201943 Ki 0.37 nM
Cc1cn2cc(C#N)cc2c(C#Cc2ccsc2)n1 CHEMBL403390 pIC50 0.3981 nM
Cc1cccc(C#Cc2nc(C)cn3cccc23)c1 CHEMBL271276 pIC50 0.3981 nM
N#Cc1cc(Cl)c(F)c(-c2cc(-c3ccc(F)cn3)ncn2)c1 CHEMBL3603926 pIC50 0.3981 nM
O=C(C#Cc1ccccc1)N1CCN(c2ccccc2[N+](=O)[O-])CC1 CHEMBL3597585 Ki 0.4 nM
O=[N+]([O-])c1cccnc1N1CCC(=CC#Cc2ccccc2)CC1 CHEMBL3597592 Ki 0.4 nM
O=C1N[C@H](c2cncc(C#Cc3ccccc3)c2)[C@@H](c2ccc(F)cc2)O1 CHEMBL4560002 EC50 0.4 nM
Cc1nc(C#Cc2ccc(-c3ccccc3)nc2)cs1 CHEMBL184995 IC50 0.5 nM
O=C(C#Cc1ccccc1)N1CCN(c2ncccc2[N+](=O)[O-])CC1 CHEMBL3597584 Ki 0.5 nM
Cc1cccc(C#CC=C2CCN(c3ncc(-c4ccccc4)cc3C#N)CC2)n1 CHEMBL3597602 Ki 0.5 nM
O=[N+]([O-])c1cccnc1N1CCC(=CC#Cc2cccc(Cl)c2)CC1 CHEMBL3597598 Ki 0.5 nM
Cc1cccc(C#CC=C2CCN(c3ncccc3[N+](=O)[O-])CC2)n1 CHEMBL3597594 Ki 0.5 nM
N#Cc1cc(Cl)c(F)c(-c2cc(-n3cccn3)ncn2)c1 CHEMBL3603915 pKi 0.5012 nM
N#Cc1cc(Cl)cc(-c2cc(-c3ccc(F)cn3)ncn2)c1 CHEMBL3603923 pKi 0.5012 nM
O=C1N[C@H](c2cncc(C#Cc3ccccc3)c2)[C@@H](c2ccc(Cl)cc2)O1 CHEMBL4588437 EC50 0.6 nM
O=C1N[C@H](c2cncc(C#Cc3ccccc3)c2)[C@@H](c2ccccc2Cl)O1 CHEMBL4571075 Ki 0.6 nM
N#Cc1ccc(-c2cc(-c3cc(Cl)cc(C#N)c3)ncn2)nc1 CHEMBL3603924 pKi 0.631 nM
Cc1cccc(C#CC=C2CCN(C(=O)c3cccc(Cl)c3)CC2)n1 CHEMBL4535926 Ki 0.7 nM
CCOC(=O)N1CCC(=CC#Cc2cccc(Cl)c2)CC1 CHEMBL4472693 Ki 0.7 nM
O=C1N[C@H](c2cncc(C#Cc3ccccc3)c2)[C@@H](c2ccccc2)O1 CHEMBL4580610 EC50 0.7 nM
O=C(Nc1ccnc(Cl)c1)c1nnn2c1CSc1c-2ccc(F)c1Cl CHEMBL3759766 IC50 0.79 nM
Cc1cn2cc(C#N)cc2c(C#Cc2cccc(F)c2)n1 CHEMBL257880 pIC50 0.7943 nM
O=C1N[C@H](c2cncc(C#Cc3ccccc3)c2)[C@@H](c2cccc(F)c2)O1 CHEMBL3805542 EC50 0.8 nM
Clc1cncc(OC2C=C(C#Cc3ccccn3)CCC2)c1 CHEMBL381192 IC50 0.9 nM
Cc1nc(C#Cc2cc(F)cc(C#N)c2)cs1 CHEMBL446543 Ki 0.9 nM
Cc1ccncc1-c1nn(C)c2nc(OCc3ccccn3)cnc12 CHEMBL3122212 Ki 0.9 nM
O=C1N[C@H](c2cncc(C#Cc3ccccc3)c2)[C@@H](c2cccc(Cl)c2)O1 CHEMBL4517787 EC50 0.9 nM
CCOC(=O)N1CCC(=CC#Cc2cccc(C#N)c2)CC1 CHEMBL4439229 Ki 0.98 nM
[3H]C([3H])([3H])Oc1cncc(C#Cc2ccccn2)c1 CHEMBL1169452 IC50 1.0 nM
Cc1cc(C#N)cc(OCc2cccc(Cl)c2)n1 CHEMBL207703 Ki 1.0 nM
O=C1CN=C(n2cnc(CCO)c2)C=C2c3cccc(C4CC4)c3CCN12 CHEMBL3644406 IC50 1.0 nM
O=C1CN=C(n2cnc(-c3ccno3)c2)C=C2c3cccc(C4CC4)c3CCN12 CHEMBL3644399 IC50 1.0 nM
O=c1cc(OCc2cccc(Cl)c2)nc2n1[C@H](Cc1ccccc1)COC2 CHEMBL4066731 Ki 1.0 nM
C=Cc1cncc(C#Cc2csc(C)n2)c1 CHEMBL202307 Ki 1.003 nM
COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2)c1 CHEMBL1080481 IC50 1.1 nM
Cc1cccc(NC(=O)c2nn(C)c(-c3ccc(F)cc3)c2C)n1 CHEMBL2349534 IC50 1.1 nM
O=C(NC12CCCC(C#Cc3cccc(F)c3)(CC1)C2)c1cnccn1 CHEMBL3960828 IC50 1.2 nM
O=C1N[C@H](c2cncc(C#Cc3ccccc3)c2)[C@@H](c2ccc(F)cc2F)O1 CHEMBL4574977 EC50 1.2 nM
Cc1cn2cc(C#N)cc2c(C#Cc2ccccc2)n1 CHEMBL404237 pIC50 1.259 nM
N#Cc1cc(Cl)c(F)c(-c2cc(-c3ccccn3)ncn2)c1 CHEMBL3603920 pKi 1.259 nM
Cc1c(Cl)cncc1-c1nn(C)c2nc(OCc3ccccn3)cnc12 CHEMBL3122215 Ki 1.3 nM
O=C1N[C@H](c2cncc(C#Cc3ccccc3)c2)[C@@H](c2cc(F)cc(F)c2)O1 CHEMBL4545607 Ki 1.4 nM
Cc1cccc(C#Cc2ccccc2)n1 CHEMBL66654 IC50 1.5 nM
CC(C)C[C@@H]1COCc2nc(OCc3cccc(C#N)c3)cc(=O)n21 CHEMBL4091620 Ki 1.5 nM
O=C1N[C@H](c2ccnc(C#Cc3ccccc3)c2)[C@@H](c2ccccc2)O1 CHEMBL4556501 EC50 1.5 nM
O=C1N[C@H](c2cncc(C#Cc3ccccc3)c2)[C@@H](c2ccccc2F)O1 CHEMBL4537236 EC50 1.5 nM
N#Cc1cc(C#N)cc(-c2cc(-c3ccc(F)cn3)ncn2)c1 CHEMBL3603922 pKi 1.585 nM
N#Cc1cc(Cl)cc(-c2cc(-c3ccc(Cl)cn3)ncn2)c1 CHEMBL3603925 pKi 1.585 nM
O=C1N[C@H](c2cncc(C#Cc3ccccc3)c2)[C@@H](c2cc(F)ccc2F)O1 CHEMBL3804846 Ki 1.6 nM
O=C(N[C@]12CCC[C@](C#Cc3ccccn3)(CC1)C2)c1ccccn1 CHEMBL3898494 IC50 1.6 nM
CO/N=C1/C=C(C#Cc2cccc(C)n2)CCC1 CHEMBL227853 Ki 1.7 nM
O=C1N[C@H](c2cncc(C#Cc3ccccc3)c2)[C@@H](c2cccc(F)c2F)O1 CHEMBL4554515 Ki 1.8 nM
Cc1nc(C#Cc2ccc(-c3cccnc3)nc2)cs1 CHEMBL369310 IC50 2.0 nM
Cc1cccc(C#Cc2csc(C)n2)c1 CHEMBL182950 IC50 2.0 nM
Cc1nc(C#Cc2cncc(-c3ccccc3)c2)cs1 CHEMBL185365 IC50 2.0 nM
Cc1cc(-c2cccc(Cl)c2)ncc1C1CCCN1C(=O)c1cncs1 CHEMBL1808873 IC50 2.0 nM
O=C1CN=C(n2cnc(C(F)F)c2)C=C2c3cccc(C4CC4)c3CCN12 CHEMBL3644362 IC50 2.0 nM
O=C1CN=C(n2cnc(CF)c2)C=C2c3cccc(C4CC4)c3CCN12 CHEMBL3639432 IC50 2.0 nM
COCc1ncn(C2=NCC(=O)N3CCc4c(ccc(F)c4C4CC4)C3=C2)n1 CHEMBL3644365 IC50 2.0 nM
CC(O)c1cn(C2=NCC(=O)N3CCc4c(cccc4C4CC4)C3=C2)cn1 CHEMBL3644429 IC50 2.0 nM
COCc1cn(C2=NCC(=O)N3CCc4c(ccc(F)c4C4CC4)C3=C2)cn1 CHEMBL3644421 IC50 2.0 nM
CCOC(=O)N1CCC(=CC#Cc2cccc(C)c2)CC1 CHEMBL4446275 Ki 2.0 nM
C(#Cc1ccccn1)C1=CC(Oc2cccnc2)CCC1 CHEMBL426467 IC50 2.2 nM
O=S(=O)(c1ccc(Br)cc1)N1CC=C(C#Cc2ccccn2)CC1 CHEMBL197724 IC50 2.2 nM
[3H]c1c(F)cc(-c2nc(-c3ccc(F)cn3)no2)cc1C#N CHEMBL2164550 Kd 2.25 nM
Cc1cccc(C#Cc2nncc(C)n2)c1 CHEMBL227200 IC50 2.3 nM
Cc1cccc(NC(=O)c2nn(C)c(-c3ccc(Cl)c(Cl)c3)c2C)n1 CHEMBL2349540 IC50 2.3 nM
Cn1nc(-c2cccnc2)c2ncc(OCc3ccccn3)nc21 CHEMBL3122210 Ki 2.3 nM
Fc1cccc(/C=N/N=C/c2cccc(F)c2)c1 CHEMBL371811 EC50 2.36 nM
C(#Cc1ccccn1)C1=CCCCC1 CHEMBL196643 IC50 2.4 nM
CCCn1c(-c2cnc(Nc3ccc(C)nc3)c(Cl)c2)nc2cccc(Cl)c21 CHEMBL1672539 Ki 2.4 nM
CN1CCc2nc(C#Cc3ccccc3)sc2C1=O CHEMBL2403659 EC50 2.4 nM
C=CC[C@@H](NC(=O)c1nccs1)c1cnc(Nc2ccc(C)nc2)c(Cl)c1 CHEMBL3601910 IC50 2.4 nM
O=C(C1CC(F)(F)C1)N1CCc2nc(C#Cc3cccc(F)c3)sc2C1 CHEMBL2403690 EC50 2.5 nM
O=C1c2sc(C#Cc3ccccc3)nc2CN1C1CCCC1 CHEMBL2403667 EC50 2.5 nM
Cc1cccc(C#CC=C2CCN(C(=O)OCCc3ccccc3)CC2)n1 CHEMBL4539036 Ki 2.5 nM
CCOC(=O)N1CCC(=CC#Cc2cccc(C)n2)CC1 CHEMBL4441707 Ki 2.5 nM
Cc1cn2cccc2c(C#Cc2ccccc2)n1 CHEMBL271477 pIC50 2.512 nM
Cc1ccc(-c2cc(-c3cc(Cl)cc(C#N)c3)ncn2)nc1 CHEMBL3603921 pKi 2.512 nM
N#Cc1cc(Cl)cc(-c2cc(-c3ccccn3)ncn2)c1 CHEMBL3603919 pIC50 2.512 nM
CC(C)(C)OC(=O)N1CC=C(C#Cc2ccccn2)CC1 CHEMBL196574 IC50 2.6 nM
CCOC(=O)N1CCC(=CC#Cc2ccccn2)CC1 CHEMBL4472416 Ki 2.6 nM
Cc1nc(C#Cc2cc(F)cc(-c3cccnc3)c2)cs1 CHEMBL511603 Ki 2.7 nM
Cc1ccc(S(=O)(=O)N2CCC(=CC#Cc3cccc(C)n3)CC2)cc1 CHEMBL4452522 Ki 2.7 nM
O=C1N[C@H](c2cncc(C#Cc3ccccc3)c2)[C@@H](c2c(F)cccc2F)O1 CHEMBL4572894 Ki 2.7 nM
Cn1nc(-c2cnccc2C(F)(F)F)c2ncc(OCc3ccccn3)nc21 CHEMBL3122213 Ki 2.8 nM
Cc1cccc(C#Cc2ccc3c(n2)CCN(C)C3=O)c1 CHEMBL1779849 IC50 2.9 nM
COc1ccc(S(=O)(=O)N2CCC(=CC#Cc3cccc(C)n3)CC2)cc1 CHEMBL4592284 Ki 2.9 nM
O=C(c1cccc(Cl)c1)N1CCC(=CC#Cc2cccc(Cl)n2)CC1 CHEMBL4455843 Ki 2.9 nM
CCN(C(=O)N1CCC(=CC#Cc2cccc(C)n2)CC1)C(C)C CHEMBL4451661 Ki 2.9 nM
Cc1cncc(C#Cc2csc(C)n2)c1 CHEMBL332396 IC50 3.0 nM
Cc1nc(C#Cc2cncc(-c3cccnc3)c2)cs1 CHEMBL183864 IC50 3.0 nM
Cc1cccc(C#Cc2cccc(Cl)c2)n1 CHEMBL245404 IC50 3.0 nM
Cc1cc(C(=O)N2CCCC2c2cnc(-c3cccc(Cl)c3)cc2C)no1 CHEMBL1808874 IC50 3.0 nM
COCc1ncn(C2=NCC(=O)N3CCc4c(cccc4C4CC4)C3=C2)n1 CHEMBL3702452 IC50 3.0 nM
CO[C@H](C)c1cn(C2=NCC(=O)N3CCc4c(cccc4C4CC4)C3=C2)cn1 CHEMBL3644397 IC50 3.0 nM
COCc1cn(C2=NCC(=O)N3CCc4c(cc(F)cc4C4CC4)C3=C2)cn1 CHEMBL3702467 IC50 3.0 nM
O=c1cc(OCc2cccc(Cl)c2)nc2n1[C@@H](Cc1ccccc1)COC2 CHEMBL4094256 Ki 3.0 nM
C(#Cc1ccccn1)C1=CCCC1 CHEMBL443487 IC50 3.1 nM
CCOC(=O)c1cc2c(C#Cc3cccc(C#N)c3)nc(C)cn2c1 CHEMBL402082 pIC50 3.162 nM
Cc1cn2cc(C#N)cc2c(C#Cc2ccccc2F)n1 CHEMBL257879 pIC50 3.162 nM
CC(C)(C)C[C@@H]1COCc2nc(OCc3cccc(C#N)c3)cc(=O)n21 CHEMBL4090712 Ki 3.3 nM
Cc1cccc(C#CC=C2CCN(S(=O)(=O)c3ccc(C#N)cc3)CC2)n1 CHEMBL4513498 Ki 3.3 nM
O=C1N[C@H](c2cncc(C#Cc3cccnc3)c2)[C@@H](c2ccc(F)cc2)O1 CHEMBL4528135 EC50 3.3 nM
CCOC(=O)N1CC/C(=C\C#Cc2cccc(C)n2)C1 CHEMBL4551786 Ki 3.5 nM
[3H]C([3H])([3H])OCc1cccc(C#Cc2cccc(C)n2)c1 CHEMBL2112677 IC50 3.6 nM
CCOC(=O)N1CC2(CC(=CC#Cc3cccc(C)n3)C2)C1 CHEMBL4551238 Ki 3.6 nM
Cc1cccc(NC(=O)c2nn(C)c(-c3ccc(F)cc3F)c2C)n1 CHEMBL2349538 IC50 3.7 nM
Cc1cccc(C(=O)NC23CCCC(NC(=O)c4cccc(Cl)c4)(CC2)C3)n1 CHEMBL3671833 IC50 3.7 nM
Cc1cccc(NC(=O)c2nn(C)c(-c3ccc(Cl)cc3)c2C)n1 CHEMBL2349535 IC50 3.8 nM
Cc1cncc(C(=O)NC23CC4CC(CC(C#Cc5cccnc5)(C4)C2)C3)n1 CHEMBL3950067 IC50 3.8 nM
N#Cc1cccc(COc2cc(=O)n3c(n2)COC[C@H]3Cc2ccccc2)c1 CHEMBL4064010 Ki 3.8 nM
N#Cc1cc(F)cc(-n2nnc(-c3ccccn3)n2)c1 CHEMBL187107 IC50 3.9 nM
O=C(C1CC12CCC2)N1CCc2nc(C#Cc3ccccc3)sc2C1 CHEMBL2403684 EC50 3.9 nM
Cc1cncc(C(=O)N[C@]23CCC[C@](NC(=O)c4cccc(F)c4)(CC2)C3)n1 CHEMBL3671838 IC50 3.9 nM
Cc1cccc(C#C/C=C2\CCN(C(=O)c3cccc(Cl)c3)C2)n1 CHEMBL4448788 Ki 3.9 nM
Cc1cc(C#N)cc(-c2cc(-n3cccn3)ncn2)c1 CHEMBL3603913 pKi 3.981 nM
N#Cc1cc(Cl)cc(-c2cc(-n3cccn3)ncn2)c1 CHEMBL3603914 pKi 3.981 nM
Cc1nc(C#Cc2ccc(-c3ccccn3)nc2)cs1 CHEMBL362217 IC50 4.0 nM
Cc1nc(C#Cc2ccccc2)cs1 CHEMBL63042 IC50 4.0 nM
Cc1csc(NC(=O)c2nc(C)cc3cc[nH]c23)n1 CHEMBL2153783 IC50 4.0 nM
O=c1cc(OCc2cccc(Cl)c2)nc2ccc(Oc3cccnc3)cn12 CHEMBL4078647 Ki 4.0 nM
CCOC(=O)N1CCC(=CC#Cc2cccc(F)c2)CC1 CHEMBL4475143 Ki 4.0 nM
COC(=O)N1CCC(=CC#Cc2cccc(C)n2)CC1 CHEMBL4544729 Ki 4.0 nM
Cc1cnnc(C#Cc2cccc(Cl)c2)n1 CHEMBL390802 IC50 4.2 nM
Cc1cccc(NC(=O)c2nn(C)c(-c3ccc(F)c(F)c3)c2C)n1 CHEMBL2349537 IC50 4.3 nM
Cc1cccc(C#CC=C2CCN(C(=O)N(C)C(C)c3ccccc3)CC2)n1 CHEMBL4548820 Ki 4.3 nM
Cc1cccc(NC(=O)c2nn(C)c(-c3ccccc3)c2C)n1 CHEMBL2349533 IC50 4.4 nM
Cc1cc(OCc2cccc(Cl)c2)cc(N2C(=O)c3ccccc3C2=O)c1 CHEMBL206422 Ki 4.7 nM
Cc1cccc(NC(=O)c2nn(C)c(-c3cccc(Cl)c3)c2C)n1 CHEMBL2349536 IC50 4.7 nM
Cc1cccc(NC(=O)C23CCCC(NC(=O)c4nc(C)cs4)(CC2)C3)n1 CHEMBL3671839 IC50 4.7 nM
O=C(NC12CC3CC(CC(C#Cc4ccccn4)(C3)C1)C2)c1cnccn1 CHEMBL3915624 Ki 4.7 nM
Cc1cccc(C#Cc2ccc3c(n2)CCN(C(C)C)C3=O)c1 CHEMBL1779860 IC50 4.8 nM
Cc1cccc(C#CC=C2CCN(C(=O)OCc3ccccc3)CC2)n1 CHEMBL4548205 Ki 4.8 nM
O=C1N[C@H](c2cncc(C#Cc3ccnc(F)c3)c2)[C@@H](c2ccc(F)cc2)O1 CHEMBL4575547 EC50 4.8 nM
CCN(CC)C(=O)c1nn(C)c2nc(OCc3ccccn3)ccc12 CHEMBL3122224 Ki 4.85 nM
N#Cc1cccc(S(=O)(=O)c2cnc3cc(F)ccc3c2-c2ccc(Cl)cc2)c1 CHEMBL3765114 Ki 4.9 nM
Cc1nc(C#Cc2cccnc2)cs1 CHEMBL292065 IC50 5.0 nM
Cc1cccc(NC(=O)c2nc(Cl)cnc2N)n1 CHEMBL361973 IC50 5.0 nM
N#Cc1cc(Cl)nc(OCc2cccc(Cl)c2)c1 CHEMBL202908 Ki 5.0 nM
Cc1cccc(C#CCCc2cccc(Cl)c2)n1 CHEMBL213001 IC50 5.0 nM
Cc1cccc(C#Cc2ccccc2Cl)n1 CHEMBL415083 IC50 5.0 nM
CCCCC1CCCCN1C(=O)c1cnc(Nc2ccc(C)nc2)c(Cl)c1 CHEMBL594767 IC50 5.0 nM
O=C(c1nccs1)N1CCCC1c1ccc(-c2cccc(Cl)c2)nc1 CHEMBL1808867 IC50 5.0 nM
Cn1nc(-c2ccccn2)c2ccc(OCc3ccccn3)nc21 CHEMBL3122208 Ki 5.0 nM
CO[C@@H](C)c1cn(C2=NCC(=O)N3CCc4c(cccc4C4CC4)C3=C2)cn1 CHEMBL3644396 IC50 5.0 nM
CCC(=O)c1cccc2c1CCN1C(=O)CN=C(n3cnc(C4CCC4)c3)C=C21 CHEMBL3644404 IC50 5.0 nM
CCCc1cccc2c1CCN1C(=O)CN=C(n3cnc(-c4ncco4)c3)C=C21 CHEMBL3702437 IC50 5.0 nM
N#Cc1cccc(-c2cc(-c3ccncn3)ncn2)c1 CHEMBL3603928 pKi 5.012 nM
CC(C)(C)n1nnc2c1CCC(c1noc(-c3ccc(F)cc3)n1)C2 CHEMBL3736161 pEC50 5.012 nM
CC(C)(C)n1nnc2c1CCC(c1nc(-c3ccc(F)cc3)no1)C2 CHEMBL3735684 pEC50 5.012 nM
Cc1cccc(-c2noc(C3CC(=O)N(c4ccc(F)cc4)C3)n2)c1 CHEMBL2069398 EC50 5.1 nM
Cc1ccc(-c2c(C)c(C(=O)Nc3cccc(C)n3)nn2C)cc1 CHEMBL2349541 IC50 5.3 nM
Cc1cccc(NC(=O)c2nn(C)c(-c3cc(F)cc(F)c3)c2C)n1 CHEMBL2349539 IC50 5.3 nM
Cc1cccc(C#C[C@]23CCC[C@](NC(=O)c4ccccn4)(CC2)C3)n1 CHEMBL4109702 IC50 5.3 nM
Cc1csc(COc2cc(=O)n3c(n2)COC[C@H]3Cc2ccccc2)n1 CHEMBL4085572 Ki 5.5 nM
COC(=O)N1CC[C@@H]2[C@H]1CCC[C@@]2(O)C#Cc1cccc(C)c1 CHEMBL3087515 Ki 5.6 nM
CC(C)N1CCc2nc(C#Cc3cccc(Cl)c3)ccc2C1=O CHEMBL1779863 IC50 5.7 nM
CN(C)S(=O)(=O)N1CCc2nc(C#Cc3ccccc3)sc2C1 CHEMBL2403651 IC50 5.7 nM
Cc1cccc(NC(=O)c2nc(C)n(-c3ccc(Cl)c(Cl)c3)c2C)n1 CHEMBL2346726 IC50 5.8 nM
CCN(C(=O)N1CC/C(=C\C#Cc2cccc(C)n2)C1)C(C)C CHEMBL4441964 Ki 5.8 nM
O=C1NC(=O)c2cc(C#Cc3ccccc3)ccc21 CHEMBL1682790 EC50 5.9 nM
O=C1c2ccc(C#Cc3ccccc3)nc2CCN1C1CCCC1 CHEMBL1779869 EC50 5.9 nM
O=C(N[C@@]12CCC[C@@](C#Cc3ccccn3)(CC1)C2)c1ccccn1 CHEMBL4111325 IC50 5.9 nM
Cc1cc(OCc2cccc(C#N)c2)cc(N2C(=O)c3ccccc3C2=O)c1 CHEMBL206579 Ki 6.0 nM
Cc1cnnc(C#Cc2cccc(Br)c2)n1 CHEMBL390803 IC50 6.0 nM
COCc1cn(C2=NCC(=O)N3CCc4c(cccc4C4CC4)C3=C2)cn1 CHEMBL3644420 IC50 6.0 nM
O=C1CN=C(n2cnc(CO)c2)C=C2c3cccc(C4CC4)c3CCN12 CHEMBL3644428 IC50 6.0 nM
CO[C@H](C)c1cn(C2=NCC(=O)N3CCc4c(ccc(F)c4C4CC4)C3=C2)cn1 CHEMBL3644363 IC50 6.0 nM
O=C1N[C@H](c2cncc(C#Cc3cncc(F)c3)c2)[C@@H](c2ccc(F)cc2)O1 CHEMBL3806078 EC50 6.0 nM
C[C@@H](Oc1nnc(-c2cn[nH]c(=O)c2)n1C)c1nnn(-c2cccc(Cl)c2)n1 CHEMBL3955421 IC50 6.0 nM
O=C(c1cnc(C#Cc2ccccc2)s1)N1CCCCC1 CHEMBL2403704 EC50 6.1 nM
CC(C)(C)C[C@@H]1COCc2nc(OCc3ccccn3)cc(=O)n21 CHEMBL4063837 Ki 6.1 nM
Cn1nc(-c2cccnc2)c2ccc(OCc3ccccn3)nc21 CHEMBL3122209 Ki 6.2 nM
Cc1csc(C(=O)N[C@]23CCC[C@](C#Cc4cnccn4)(CC2)C3)n1 CHEMBL3947392 Ki 6.2 nM
Cc1cn2cc(-c3nc(C)no3)cc2c(C#Cc2ccccc2)n1 CHEMBL271065 pIC50 6.31 nM
Cc1cccc(C#C/C=C2\CCN(C(=O)c3ccco3)C2)n1 CHEMBL4542890 IC50 6.4 nM
Cn1nc(-c2ncccc2OC(F)F)c2ncc(OCc3ccccn3)nc21 CHEMBL3122214 Ki 6.5 nM
O=C1N[C@H](c2cccc(C#Cc3ccccc3)c2)[C@@H](c2cccc(F)c2)O1 CHEMBL3805340 Ki 6.5 nM
C[C@@H]1CCCN1C(=O)c1nn(C)c2nc(OCc3ccccn3)ccc12 CHEMBL3122225 Ki 6.6 nM
O=C(N[C@]12CCC[C@](C#Cc3ccccn3)(CC1)C2)c1cnccn1 CHEMBL3923012 IC50 6.6 nM
Fc1cc(Oc2cccnc2)cc(-n2nnc(-c3ccccn3)n2)c1 CHEMBL186151 IC50 6.7 nM
CN1CC(=O)N=C1NC(=O)Nc1cccc(Cl)c1 CHEMBL239800 pKi 6.761 nM
Cc1csc(NC(=O)c2cc(F)cc(Oc3cncnc3)c2)n1 CHEMBL2440659 Ki 6.8 nM
[3H]C([3H])([3H])OCc1cncc(C#Cc2csc(C)n2)c1 CHEMBL1169453 IC50 7.0 nM
Cc1cccc(NC(=O)c2nc(C)ccc2O)n1 CHEMBL180964 IC50 7.0 nM
CCn1nc(-c2cnccc2C)c2ncc(OCc3ccccn3)nc21 CHEMBL3122218 Ki 7.0 nM
Cc1nc(C#Cc2ccnc(Cl)c2)c(C)n1-c1ccc(F)cc1 CHEMBL3301626 IC50 7.0 nM
CO[C@H](C)c1cn(C2=NCC(=O)N3CCc4c(C5CC5)ccc(F)c4C3=C2)cn1 CHEMBL3702466 IC50 7.0 nM
O=C1CN=C(n2cnc(C3CC3)c2)C=C2c3cccc(-c4ncco4)c3CCN12 CHEMBL3644372 IC50 7.0 nM
COCc1cn(C2=NCC(=O)N3CCc4c(C5=CCCC5)cccc4C3=C2)cn1 CHEMBL3644394 IC50 7.0 nM
COc1cc(C2=NCC(=O)N3CCc4c(cccc4-c4ccc(F)nc4)C3=C2)ccn1 CHEMBL3702403 IC50 7.0 nM
O=C1CN=C(n2cnc(C3(O)CC3)c2)C=C2c3cccc(C4CC4)c3CCN12 CHEMBL3644405 IC50 7.0 nM
Cc1cccc(-n2nnc([C@@H](C)Oc3nnc(-c4cn[nH]c(=O)c4)n3C)n2)c1 CHEMBL3759977 IC50 7.0 nM
CC1(C)CN(c2ccc(C#Cc3ccccc3)cn2)C(=O)O1 CHEMBL3974960 EC50 7.0 nM
CN1C(=O)N(c2ncc(C#Cc3cc(F)ccc3F)cn2)CC1(C)C CHEMBL3979539 EC50 7.0 nM
O=c1cc(OCc2cccc(Cl)c2)nc2ccccn12 CHEMBL4089073 Ki 7.0 nM
Cc1c(C(=O)Nc2ccnc(Cl)n2)nn(C)c1-c1ccc(F)cc1 CHEMBL2346721 IC50 7.1 nM
Cc1cccc(C#Cc2ccc3c(n2)CCN(C2CCCC2)C3=O)c1 CHEMBL1779871 EC50 7.5 nM
Cc1cccc(C#Cc2cncnc2)c1 CHEMBL508497 IC50 7.5 nM
Cc1ccc(Nc2ncc([C@H](NC(=O)c3nccs3)C(C)C)cc2Cl)cn1 CHEMBL3601902 IC50 7.5 nM
N#Cc1cc(F)cc(-c2nc(-c3ccc(F)cn3)no2)c1 CHEMBL2164551 IC50 7.6 nM
CCN(CC)C(=O)c1nn(C)c2nc(OCc3cccc(C)n3)ccc12 CHEMBL3122223 Ki 7.8 nM
Cc1ccc(S(=O)(=O)N2CC=C(C#Cc3ccccn3)CC2)cc1 CHEMBL194538 IC50 7.9 nM
CCOC(=O)c1cc2c(C#Cc3ccsc3)nc(C)cn2c1 CHEMBL438156 pIC50 7.943 nM
Cc1c(C(C)OC(=O)Nc2ccccc2)oc2nc(-c3cccs3)nn12 CHEMBL1630067 pIC50 7.943 nM
Cc1cccc(NC(=O)c2nc(C)cnc2N)n1 CHEMBL180713 IC50 8.0 nM
COc1cc(-c2cccc(Cl)c2)ncc1C1CCCN1C(=O)C1CCC1 CHEMBL1808885 IC50 8.0 nM
COc1cc(-c2cccc(Cl)c2)ncc1C1CCCN1C(=O)c1cncs1 CHEMBL1808884 IC50 8.0 nM
O=C(c1cccs1)N1CCCC1c1ccc(-c2cccc(Cl)c2)nc1 CHEMBL1808866 IC50 8.0 nM
O=C1CN=C(n2cnc(C3CC3)n2)C=C2c3cccc(C4CC4)c3CCN12 CHEMBL3644400 IC50 8.0 nM
O=C1N[C@H](c2cncc(C#CC3CCC3)c2)[C@@H](c2cccc(F)c2)O1 CHEMBL3949965 EC50 8.0 nM
C[C@@H](Oc1nnc(-c2cn[nH]c(=O)c2)n1C)c1cc(-c2cccc(Cl)c2)on1 CHEMBL3896304 IC50 8.0 nM
Cc1c(-c2nn(C)c3nc(OCc4ccccn4)cnc23)cnn1C CHEMBL3122217 Ki 8.1 nM
O=C(Nc1cccc(Cl)n1)c1cc(Cl)cc(Oc2cncnc2)c1 CHEMBL2440625 IC50 8.1 nM
Cc1cccc(S(=O)(=O)N2CC=C(C#Cc3ccccn3)CC2)c1 CHEMBL195944 IC50 8.2 nM
CCC[C@@H](NC(=O)c1nccs1)c1cnc(Nc2ccc(C)nc2)c(Cl)c1 CHEMBL3601900 IC50 8.2 nM
C(#Cc1ccccn1)C1=CC(Nc2cccnc2)CCC1 CHEMBL197212 IC50 8.6 nM
Cc1cccc(C#C/C=C2\CCN(C(=O)N(C)C(C)C)C2)n1 CHEMBL4464022 Ki 8.6 nM
O=C(c1cccc(Cl)c1)N1CCc2nc(C#Cc3ccccc3)sc2C1 CHEMBL2403589 EC50 8.7 nM
O=C1CC(c2nc(-c3cccc(Cl)c3)no2)CN1c1ccc(F)cc1 CHEMBL2069397 EC50 8.8 nM
C/C=C/C[C@@H](NC(=O)c1nccs1)c1cnc(Nc2ccc(C)nc2)c(Cl)c1 CHEMBL3601911 IC50 8.8 nM
O=C1N[C@H](c2cccc(C#Cc3ccccc3)c2)[C@@H](c2ccccc2)O1 CHEMBL4516570 Ki 8.9 nM
O=C(c1cncs1)N1CCCC1c1ccc(-c2cccc(Cl)c2)nc1 CHEMBL1808868 IC50 9.0 nM
Cc1cccc(NC(=O)c2nc(C)sc2Nc2cccnc2)n1 CHEMBL2171702 Ki 9.0 nM
Cc1cc(C#Cc2ncn3c2COc2ccccc2-3)ccn1 CHEMBL3410213 IC50 9.0 nM
COCc1cn(C2=NCC(=O)N3CCc4c(cccc4C4CCC4)C3=C2)cn1 CHEMBL3702450 IC50 9.0 nM
CCc1cn(C2=NCC(=O)N3CCc4c(cccc4-c4ccco4)C3=C2)cn1 CHEMBL3702423 IC50 9.0 nM
C[C@@H](Oc1nnc(-c2cc[nH]c(=O)c2)n1C)c1nnn(-c2cccc(Cl)c2)n1 CHEMBL3920519 IC50 9.0 nM
Cc1cncc(C(=O)NC23CCCC(NC(=O)c4cccc(F)c4)(CC2)C3)n1 CHEMBL3671834 IC50 9.0 nM
CC1(C)CN(c2ccc(C#Cc3cccc(F)c3)cn2)C(=O)O1 CHEMBL3945569 EC50 9.0 nM
Cc1ccc(Nc2ncc([C@H](NC(=O)c3nccs3)C3CCC3)cc2Cl)cn1 CHEMBL3601906 IC50 9.3 nM
O=C(Nc1cccc(F)n1)c1cc(Cl)cc(Oc2cncnc2)c1 CHEMBL2440624 IC50 9.3 nM
O=C(N[C@@]12CCC[C@@](C#Cc3ncccc3F)(CC1)C2)c1cnccn1 CHEMBL4108911 IC50 9.3 nM
CC1CC1C(=O)N1CCc2nc(C#Cc3ccccc3)sc2C1 CHEMBL2403683 EC50 9.4 nM
O=C1N[C@H](c2cccc(C#Cc3ccccc3)n2)[C@@H](c2ccccc2)O1 CHEMBL4552721 EC50 9.4 nM
Cc1ccc(Nc2ncc([C@H](NC(=O)c3nccs3)C3CC3)cc2Cl)cn1 CHEMBL3601905 IC50 9.7 nM
Cc1cccc(NC(=O)c2ccc(-c3ccccc3)c(C#N)c2)n1 CHEMBL466006 Ki 9.8 nM
O=C(N1CCCC1)N1CCc2nc(C#Cc3ccccc3)sc2C1 CHEMBL2403584 EC50 9.8 nM