N#Cc1ccc(Nc2nccc(C(=O)Nc3cnccc3OCC(F)(F)F)n2)cc1 CHEMBL5409061 IC50 0.07 nM
O=C(Nc1n[nH]c2nnc(-c3cccnc3)cc12)C1CC1 CHEMBL35785 cKi 0.08 nM
CC1CN(c2ccncc2NC(=O)c2ccnn3cc(-c4ccccc4)nc23)CCO1 CHEMBL5270781 IC50 0.09 nM
O=C(Nc1cnccc1OCC(F)(F)F)c1ccnn2cc(-c3ccccc3)nc12 CHEMBL5286391 IC50 0.09 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccnn3cc(-c4ccccc4)nc23)CCO1 CHEMBL5266553 IC50 0.1 nM
O=C(Nc1n[nH]c2nnc(-c3cccc(F)c3F)cc12)C1CCCC1 CHEMBL287092 cKi 0.11 nM
O=C(Nc1cnccc1N1CCC(F)(F)CC1)c1ccnc(Nc2ccccc2)n1 CHEMBL5437994 IC50 0.15 nM
N#Cc1ccc(Nc2nccc(C(=O)Nc3cncnc3OCC(F)(F)F)n2)cc1 CHEMBL5428013 IC50 0.15 nM
O=C(Nc1cnccc1OCC(F)(F)F)c1ccnc(Nc2ccccc2)n1 CHEMBL5416472 IC50 0.16 nM
N#Cc1ccc(Nc2nccc(C(=O)Nc3cnccc3-c3ccccc3)n2)cc1Cl CHEMBL5440672 IC50 0.16 nM
O=C(Nc1cnccc1-c1ccc(F)cc1C(F)(F)F)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5268185 IC50 0.17 nM
COc1ccc(Nc2nccc(C(=O)Nc3cnccc3-c3ccccc3)n2)cc1F CHEMBL5418606 IC50 0.17 nM
O=C(Nc1cnccc1N1CCC(F)(F)CC1)c1ccnn2cc(C3CC3)nc12 CHEMBL5282376 IC50 0.18 nM
O=C(Nc1cnccc1OCC(F)(F)F)c1ccnc(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL5422776 IC50 0.18 nM
CCN1CCC(CC(=O)Nc2n[nH]c3nnc(-c4cccc(F)c4F)cc23)CC1 CHEMBL38425 cKi 0.19 nM
O=C(Nc1cnccc1-c1ccc(F)cc1)c1ccnc(Nc2ccccc2)n1 CHEMBL5414726 IC50 0.19 nM
CS(=O)(=O)c1ccc(Nc2nccc(C(=O)Nc3cnccc3-c3ccccc3)n2)cc1 CHEMBL5407971 IC50 0.19 nM
O=C(Nc1cnccc1N1CCOCC1)c1ccnn2cc(-c3ccccc3)nc12 CHEMBL5282319 IC50 0.21 nM
O=C(Nc1cnccc1N1CCC(F)(F)CC1)c1ccnn2cc(-c3ccccc3)nc12 CHEMBL5270555 IC50 0.22 nM
Cc1ccc(Nc2nccc(C(=O)Nc3cnccc3-c3ccccc3)n2)cc1 CHEMBL5436595 IC50 0.22 nM
O=C(Nc1cnccc1N1CCOCC1)c1ccnn2cc(-c3ccc(C(F)(F)F)cc3)nc12 CHEMBL5283650 IC50 0.23 nM
O=C(Nc1cnccc1N1CCCCC1)c1ccnn2cc(-c3ccccc3)nc12 CHEMBL5282654 IC50 0.24 nM
N#Cc1ccc(Nc2nccc(C(=O)Nc3cnccc3-c3ccc(F)cc3)n2)cc1 CHEMBL5419652 IC50 0.25 nM
O=C(Nc1cnccc1-c1ccc(F)cc1)c1ccnc(Nc2ccc(OC(F)F)cc2)n1 CHEMBL5422112 IC50 0.26 nM
O=C(Nc1cnccc1-c1ccc(F)cc1Cl)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5290300 IC50 0.28 nM
Cc1cc(Nc2n[nH]c3ncc(F)cc23)nc(C2CCCCCC2)n1 CHEMBL3652543 IC50 0.3 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(Nc2ccc(Cl)cc2)n1 CHEMBL5414551 IC50 0.3 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(Nc2ccc(OC(F)F)cc2)n1 CHEMBL5435368 IC50 0.3 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(Nc2ccccc2)n1 CHEMBL5424348 IC50 0.31 nM
C[C@H]1COCCN1c1ccncc1NC(=O)c1ccnn2cc(-c3ccccc3)nc12 CHEMBL5288788 IC50 0.32 nM
C[C@@H]1CN(c2ccncc2NC(=O)c2ccnn3cc(-c4ccccc4)nc23)CCO1 CHEMBL5316226 IC50 0.34 nM
O=C(Nc1cnccc1-c1ccc(F)cc1F)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5273872 IC50 0.34 nM
N#Cc1ccc(Nc2nccc(C(=O)Nc3cnccc3-c3ccccc3)n2)cc1 CHEMBL5404581 IC50 0.35 nM
Cc1cc(C#N)ccc1Nc1nccc(C(=O)Nc2cnccc2-c2ccccc2)n1 CHEMBL5404070 IC50 0.35 nM
COc1ccccc1-c1cn2nccc(C(=O)Nc3cnccc3N3CCOC(C)C3)c2n1 CHEMBL5273327 IC50 0.38 nM
CC1(C)CC(=O)C2=C(C1)Nc1n[nH]c(C(F)(F)F)c1[C@]2(C)c1ccccc1 CHEMBL5200578 IC50 0.4 nM
CS(=O)(=O)c1ccncc1NC(=O)c1ccnn2cc(-c3ccccc3)nc12 CHEMBL5285386 IC50 0.4 nM
COc1ccc(Nc2nccc(C(=O)Nc3cnccc3-c3ccccc3)n2)cc1 CHEMBL5438689 IC50 0.4 nM
CC(C)Oc1ccncc1NC(=O)c1ccnn2cc(-c3ccccc3)nc12 CHEMBL5290040 IC50 0.41 nM
O=C(Nc1cnccc1-c1ccc(F)cc1)c1ccnn2cc(C3CC3)nc12 CHEMBL5274844 IC50 0.44 nM
COc1ccc(-c2ccncc2NC(=O)c2ccnc(NC(=O)C3CC3)c2)cc1 CHEMBL5269649 IC50 0.45 nM
O=C(Nc1cnccc1-c1ccc(F)cc1)c1ccnc(Nc2ccc(F)cc2)n1 CHEMBL5402829 IC50 0.45 nM
Cc1cc(Nc2n[nH]c3ncc(F)cc23)nc(C2CCCCC2)n1 CHEMBL3652545 IC50 0.5 nM
O=C(Nc1cncnc1OCC(F)(F)F)c1ccnc(Nc2ccccc2)n1 CHEMBL5417065 IC50 0.56 nM
CC1CN(c2ccncc2NC(=O)c2ccnn3cc(-c4ccc(C(F)(F)F)cc4)nc23)CCO1 CHEMBL5286737 IC50 0.57 nM
Cc1cc(Nc2n[nH]c3ncc(F)cc23)nc(-c2ccccc2)c1C CHEMBL3661033 IC50 0.6 nM
CC(C)c1c2cc(-c3ccnc(Nc4ccc5c(N6CCN(C)CC6)ccnc5c4)n3)ccc2nn1C CHEMBL4856177 IC50 0.6 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(Nc2ccncc2)n1 CHEMBL5401931 IC50 0.63 nM
Nc1nc(NCCNc2ncc(-c3ncc[nH]3)c(-c3ccc(Cl)cc3Cl)n2)ccc1[N+](=O)[O-] CHEMBL1080901 IC50 0.65 nM
O=C(Nc1cnccc1-c1ccccc1C(F)(F)F)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5265990 IC50 0.66 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(Nc2cccnc2)n1 CHEMBL5410129 IC50 0.69 nM
Cc1nc(C2CCCCC2)nc(Nc2n[nH]c3ncc(F)cc23)c1C CHEMBL3652540 IC50 0.7 nM
O=C(Nc1cnccc1-c1ccc(F)cc1)c1ccnc(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL5431425 IC50 0.7 nM
CC(C)(C)COc1ccncc1NC(=O)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5270885 IC50 0.74 nM
O=C(Nc1n[nH]c2nc(-c3ccc(O)cc3)c(Br)cc12)C1CC1 CHEMBL260417 IC50 0.8 nM
CC1CN(c2ccncc2NC(=O)c2ccnn3cc(C4CC4)nc23)CCO1 CHEMBL5274596 IC50 0.8 nM
Cc1ccncc1NC(=O)c1ccnn2cc(-c3ccccc3)nc12 CHEMBL5286819 IC50 0.8 nM
O=C(Nc1cnccc1-c1ccccc1Cl)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5280241 IC50 0.88 nM
O=C(Nc1cnccc1-c1ccc(F)cc1)c1ccnc(Nc2ccc(Cl)cc2)n1 CHEMBL5432510 IC50 0.88 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(Nc2ccc(OC(F)(F)F)cc2)n1 CHEMBL5433893 IC50 0.89 nM
CCN1CCC(C(=O)Nc2n[nH]c3nnc(-c4cccc(F)c4F)cc23)CC1 CHEMBL39300 cKi 0.95 nM
O=C(Nc1n[nH]c2nc(-c3ccc(O)cc3)c(Cl)cc12)C1CC1 CHEMBL260664 IC50 1.0 nM
CN1CCC(C(=O)Nc2n[nH]c3nc(-c4ccc(O)cc4)c(Br)cc23)CC1 CHEMBL261129 IC50 1.0 nM
Cc1cc(Nc2n[nH]c3ncc(F)cc23)nc([C@H]2CCCC[C@@H]2C)n1 CHEMBL3652548 IC50 1.0 nM
Cc1nc(Nc2n[nH]c3ncc(F)cc23)cc(C2CCC(F)(F)CC2)n1 CHEMBL3652541 IC50 1.0 nM
C[C@@H]1COCCN1c1ccncc1NC(=O)c1ccnn2cc(-c3ccccc3)nc12 CHEMBL5276944 IC50 1.0 nM
O=C1NC(=O)C(c2cnc3ccccn23)=C1c1cn2c3c(cc(F)cc13)CN(C(=O)N1CCCCC1)CC2 CHEMBL362558 IC50 1.02 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnn2cc(-c3ccccc3)nc12 CHEMBL5286669 IC50 1.1 nM
O=C(Nc1cnccc1-c1ccc(F)cc1)c1ccnn2cc(-c3ccccc3)nc12 CHEMBL5284042 IC50 1.1 nM
O=C(Nc1cnccc1Oc1ccccc1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5284458 IC50 1.1 nM
Cc1ccc(-c2ccncc2NC(=O)c2ccnc(NC(=O)C3CC3)c2)cc1 CHEMBL5287898 IC50 1.1 nM
O=C(Nc1cnccc1-c1ccc(Cl)cc1F)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5281592 IC50 1.2 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL5420646 IC50 1.2 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccc[nH]2)C(=O)N3)c1)Cc1ccccc1 CHEMBL1980407 pKi 1.259 nM
O=C(Nc1cnccc1N1CCOCC1)c1ccnn2c(NCC3CC3)cnc12 CHEMBL5271582 IC50 1.4 nM
O=C(Nc1cnccc1N1CCC(F)(F)CC1)c1ccnn2c(NCC3CC3)cnc12 CHEMBL5285422 IC50 1.4 nM
CC(C)Oc1ccncc1NC(=O)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5283654 IC50 1.4 nM
Cn1cc(C2=C(c3cccc(NCC(O)CO)c3)C(=O)NC2=O)c2cc(F)ccc21 CHEMBL1082152 Kd 1.5 nM
O=C1NC(=O)C(c2cn3c4c(cc(F)cc24)CN(C(=O)N2CCCCC2)CC3)=C1c1cn2ccccc2n1 CHEMBL5178166 IC50 1.5 nM
CC1CN(c2ccncc2NC(=O)c2ccnn3c(NCC4CC4)cnc23)CCO1 CHEMBL5279845 IC50 1.6 nM
N#Cc1ccc(Nc2nccc(C(=O)Nc3cnccc3-c3ccccc3)n2)c(Cl)c1 CHEMBL5428489 IC50 1.6 nM
O=C(Nc1cnccc1-c1ccc(F)cc1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5288565 IC50 1.7 nM
O=C(Nc1cnccc1OCC1CC1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5271618 IC50 1.8 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(Nc2c(F)cc(Cl)cc2F)n1 CHEMBL5434336 IC50 1.8 nM
N#Cc1ccc(-c2ccncc2NC(=O)c2ccnc(NC(=O)C3CC3)c2)cc1 CHEMBL5272425 IC50 1.9 nM
N#Cc1cc(F)ccc1-c1ccc(CSc2nnc(-c3ccc4c(c3)OCO4)o2)cc1 CHEMBL2064532 IC50 2.0 nM
N#Cc1cc(F)ccc1-c1ccc(CSc2nnc(-c3ccc4c(c3)OCCO4)o2)cc1 CHEMBL2064535 IC50 2.0 nM
CC(=O)Nc1cc(-c2nnc(SCc3ccc(-c4ccccc4C#N)cc3)o2)ccn1 CHEMBL2391102 IC50 2.0 nM
Cc1cc(Nc2c[nH]c3ncc(F)cc23)nc(C23CC4CC(CC(C4)C2)C3)n1 CHEMBL3652549 IC50 2.0 nM
Cc1cc(Nc2n[nH]c3ncc(F)cc23)nc(C2CCCC2)n1 CHEMBL3652544 IC50 2.0 nM
Cc1cc(Nc2n[nH]c3ncc(F)cc23)nc(-c2ccccc2Cl)c1 CHEMBL3661031 IC50 2.0 nM
Cc1cc(Nc2n[nH]c3ccc(F)cc23)nc(C2CCCCC2)n1 CHEMBL3652551 IC50 2.0 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnn2c(NCC3CC3)cnc12 CHEMBL5272860 IC50 2.0 nM
O=C(Nc1cnccc1-c1ccc(Cl)cc1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5278465 IC50 2.0 nM
O=C(Nc1cnccc1-c1ccc(Cl)cc1Cl)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5280368 IC50 2.1 nM
O=C(Nc1cnccc1OCC(F)(F)F)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5276348 IC50 2.2 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 2.4 nM
O=C(Nc1cnccc1N1CCC(F)(F)CC1)c1ccnn2ccnc12 CHEMBL5277960 IC50 2.4 nM
CN(C)CCCC(=O)Nc1n[nH]c2nnc(-c3ccccc3)cc12 CHEMBL259744 cKi 2.5 nM
CCOc1ccncc1NC(=O)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5286900 IC50 2.7 nM
O=C(Nc1cnc(Cl)cc1N1CCC(F)(F)CC1)c1ccnn2cc(-c3ccccc3)nc12 CHEMBL5278224 IC50 2.9 nM
O=[N+]([O-])c1ccccc1-c1ccc(CSc2nnc(-c3ccc4c(c3)OCO4)o2)cc1 CHEMBL2391122 IC50 3.0 nM
CC(C)(O)c1cc(Nc2n[nH]c3ncc(F)cc23)nc(C2CCCCC2)n1 CHEMBL3652550 IC50 3.0 nM
Fc1cnc2[nH]nc(Nc3cc(C(F)(F)F)cc(-c4ccccc4Cl)n3)c2c1 CHEMBL3661029 IC50 3.0 nM
Cc1cc(Nc2n[nH]c3ncc(F)cc23)nc(C2CCOCC2)n1 CHEMBL3652547 IC50 3.0 nM
O=C(Nc1cnccc1-c1ccc(OC(F)F)cc1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5289893 IC50 3.1 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 3.162 nM
CC1CN(c2ccncc2NC(=O)c2ccnn3ccnc23)CCO1 CHEMBL5271404 IC50 3.2 nM
O=C(Nc1cnccc1OCCO)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5273478 IC50 3.2 nM
O=C(Nc1cnccc1-c1ccccc1F)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5288364 IC50 3.3 nM
CC(C)Oc1ccncc1NC(=O)c1ccnn2c(NCC3CC3)cnc12 CHEMBL5286503 IC50 3.4 nM
O=C(Nc1cccnc1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5277187 IC50 3.9 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL2005936 pKi 3.981 nM
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1973540 pKi 3.981 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 3.981 nM
Nc1nnc(-c2cc3c(Oc4ccc(Cl)cc4)cncc3s2)o1 CHEMBL1994830 pKi 3.981 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cc(F)ccc1F CHEMBL1995811 pKi 3.981 nM
CCCC(=O)Nc1n[nH]c2nnc(-c3ccccc3)cc12 CHEMBL288143 IC50 4.0 nM
CCN1CCN(CCCC(=O)Nc2n[nH]c3nc(-c4ccc(O)cc4)c(Br)cc23)CC1 CHEMBL407981 IC50 4.0 nM
O=C1Cc2c([nH]c3ccc([N+](=O)[O-])cc23)-c2ccccc2N1 CHEMBL50894 IC50 4.0 nM
N#Cc1cccc(-c2ccc(CSc3nnc(-c4ccc5c(c4)OCO5)o3)cc2)c1 CHEMBL2391121 IC50 4.0 nM
O=[N+]([O-])c1ccccc1-c1ccc(CSc2nnc(-c3ccc4c(c3)OCCO4)o2)cc1 CHEMBL2391129 IC50 4.0 nM
CCCCC(=O)Nc1n[nH]c2nnc(-c3ccccc3)cc12 CHEMBL4172418 IC50 4.0 nM
N#CCc1ccc(Nc2nccc(Nc3cc(C4CC4)[nH]n3)n2)cc1 CHEMBL1235645 IC50 4.0 nM
Cc1n[nH]c2ccc(-c3nnc4n3[C@H](c3ccc(Cl)cc3)CC4)cc12 CHEMBL5434183 Kd 4.3 nM
O=C(O)c1ccc(Nc2ncc([N+](=O)[O-])c(NC34CC5CC(CC(O)(C5)C3)C4)n2)cc1 CHEMBL402902 IC50 4.5 nM
COc1ccncc1NC(=O)c1ccnc(NC(=O)C2CC2)c1 CHEMBL4213175 IC50 4.5 nM
O=C(Nc1cnccc1Cl)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5274152 IC50 4.5 nM
O=C(Nc1n[nH]c2nc(-c3ccc(O)c(Br)c3)ccc12)C1CC1 CHEMBL260416 IC50 5.0 nM
CN(C)CCCC(=O)Nc1n[nH]c2nnc(-c3cccc(F)c3F)cc12 CHEMBL41783 IC50 5.0 nM
O=C(Nc1n[nH]c2ncc(-c3ccccc3)cc12)C1CCCC1 CHEMBL258483 IC50 5.0 nM
CCN1CCN(CCCCC(=O)Nc2n[nH]c3nnc(-c4ccccc4)cc23)CC1 CHEMBL259271 IC50 5.0 nM
O=C(CCCN1CCOCC1)Nc1n[nH]c2nnc(-c3ccccc3)cc12 CHEMBL261518 IC50 5.0 nM
O=C1Nc2cc(Br)ccc2/C1=C1/Nc2ccccc2/C1=N\O CHEMBL409450 IC50 5.0 nM
COc1ccc(-c2ccc(CSc3nnc(-c4ccc5c(c4)OCO5)o3)cc2)c(C#N)c1 CHEMBL2391118 IC50 5.0 nM
COc1ccc(-c2ccc(CSc3nnc(-c4ccc5c(c4)OCCO5)o3)cc2)c(C#N)c1 CHEMBL2391125 IC50 5.0 nM
CCCc1ccc2nccc(NC(=O)Nc3cccc(C(F)(F)F)n3)c2c1 CHEMBL1987430 pKi 5.012 nM
O=C(Nc1cnccn1)Nc1ccnc2c(F)cccc12 CHEMBL1975647 pKi 5.012 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2cc(C(F)(F)F)ccc12 CHEMBL1973483 pKi 5.012 nM
O=C1Cc2c([nH]c3ccc(Br)cc23)-c2ncccc2N1 CHEMBL336961 pKi 5.012 nM
O=C(Nc1cccnc1)c1ccnn2cc(-c3ccccc3)nc12 CHEMBL5269379 IC50 5.3 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5270581 IC50 5.5 nM
Cc1cc2c(NC(=O)C3CC3)n[nH]c2nc1-c1ccc(O)cc1 CHEMBL260662 IC50 6.0 nM
N#Cc1ccc(-c2ccc(CSc3nnc(-c4ccc5c(c4)OCO5)o3)cc2)cc1 CHEMBL2064515 IC50 6.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 6.0 nM
Fc1ccc(/C=N/Nc2ncnc3c2cnn3-c2ccccc2)cc1 CHEMBL303926 IC50 6.2 nM
O=C(Nc1cnccc1C(F)(F)F)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5267631 IC50 6.3 nM
COc1cccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)c1 CHEMBL1980435 pKi 6.31 nM
CCOc1ccccc1C=NNC(=O)c1nnn(-c2nonc2N)c1N1CCCC1 CHEMBL1992732 pKi 6.31 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1Cl CHEMBL1965660 pKi 6.31 nM
O=C(Nc1cnccn1)Nc1ccnc2c(C(F)(F)F)cccc12 CHEMBL1994538 pKi 6.31 nM
N#Cc1ccc(NC(=O)Nc2ccnc3cc(C(F)(F)F)ccc23)nc1 CHEMBL1999718 pKi 6.31 nM
Cc1nnc(-c2cc3c(Oc4ccc(C(F)(F)F)cc4)cncc3s2)o1 CHEMBL1988153 pKi 6.31 nM
O=C(Nc1cnccc1-c1cccc(F)c1F)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5282961 IC50 6.4 nM
Cc1n[nH]c2ncc(-c3nnc4n3[C@H](c3ccc(Cl)cc3)CC4)cc12 CHEMBL5425043 Kd 6.5 nM
O=C(Nc1cnccc1-c1ccc(OC(F)(F)F)cc1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5278701 IC50 6.9 nM
O=C(Nc1n[nH]c2nc(-c3cccs3)c(Br)cc12)C1CCCC1 CHEMBL407980 IC50 7.0 nM
O=C(Nc1n[nH]c2nc(-c3ccco3)c(Br)cc12)C1CC1 CHEMBL408564 IC50 7.0 nM
O=C(Nc1n[nH]c2nc(-c3ccc(O)c(Cl)c3)ccc12)C1CC1 CHEMBL259838 IC50 7.0 nM
CCCC(=O)Nc1n[nH]c2ncc(-c3cccc(F)c3F)cc12 CHEMBL264161 IC50 7.0 nM
CCCC(=O)Nc1n[nH]c2cnc(-c3ccccc3)cc12 CHEMBL261549 IC50 7.0 nM
CCN1CCN(CCCC(=O)Nc2n[nH]c3nnc(-c4ccccc4)cc23)CC1 CHEMBL409738 IC50 7.0 nM
COc1ccc(-c2ccc(CSc3nnc(-c4ccc5c(c4)OCO5)o3)cc2)cc1 CHEMBL2391119 IC50 7.0 nM
COCCN1CCN(Cc2ccc(-c3n[nH]c4c3C(=O)c3c(NC(=O)NN5CCOCC5)cccc3-4)cc2)CC1 CHEMBL3545083 Kd apparent 7.0 nM
Nc1nc(NCCNc2ncc(-n3ccnc3)c(-c3ccc(Cl)cc3Cl)n2)ccc1[N+](=O)[O-] CHEMBL3185148 IC50 7.0 nM
COc1cc(F)ccc1-c1cc(Nc2cc(CS(C)(=O)=O)ccn2)ncc1F CHEMBL5087022 Kd 7.4 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1 CHEMBL2386747 IC50 7.44 nM
COc1cncc(NC(=O)c2ccnn3cc(-c4ccccc4)nc23)c1 CHEMBL5278638 IC50 7.5 nM
Cc1cnc(-c2cnc(NCCNc3ccc(C#N)cn3)nc2-c2ccc(Cl)cc2Cl)[nH]1 CHEMBL412142 IC50 7.8 nM
Cn1cc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cn1 CHEMBL1984548 pKi 7.943 nM
O=C1Cc2c([nH]c3ccc(Br)cc23)-c2ccccc2N1 CHEMBL296586 pKi 7.943 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(O)c2)n1 CHEMBL243088 pKi 7.943 nM
O=C(Nc1n[nH]c2nc(-c3ccc(O)cc3)ccc12)C1CC1 CHEMBL405145 IC50 8.0 nM
O=C(Nc1n[nH]c2nc(-c3ccc(O)c(O)c3)ccc12)C1CC1 CHEMBL260345 IC50 8.0 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(Nc2ccc(Cl)cc2)c1 CHEMBL5409415 IC50 8.6 nM
CN1CCC(C(=O)Nc2n[nH]c3nnc(-c4ccccc4)cc23)CC1 CHEMBL406125 IC50 9.0 nM
O=C(O)COc1ccc(Nc2ncc3nnn(-c4ccccc4)c3n2)cc1 CHEMBL402541 IC50 9.0 nM
c1ccc(-c2ccc(CSc3nnc(-c4ccc5c(c4)OCO5)o3)cc2)cc1 CHEMBL2064531 IC50 9.0 nM
N#Cc1cccc(-c2ccc(CSc3nnc(-c4ccc5c(c4)OCCO5)o3)cc2)c1 CHEMBL2391130 IC50 9.0 nM
[11CH3]n1cc(C2=C(c3ccc(Cl)cc3Cl)C(=O)NC2=O)c2ccccc21 CHEMBL3582401 Ki 9.0 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4F)c3c2s1 CHEMBL3894571 IC50 9.11 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccc(F)cc3)cc12 CHEMBL1986499 pKi 10.0 nM
O=C(Nc1cccc(N2CCOCC2)n1)Nc1ccnc2c(C(F)(F)F)cccc12 CHEMBL1972119 pKi 10.0 nM
O=C(Nc1cnccn1)Nc1ccnc2ccc(N3CC4COCC4C3)cc12 CHEMBL2002599 pKi 10.0 nM
Cc1cc(Nc2n[nH]c3ncc(F)cc23)nc(-c2ccccc2Cl)c1C CHEMBL3661030 IC50 10.0 nM
COc1ccc(-c2ocnc2C(=O)NCCCn2cncn2)cc1Cl CHEMBL5173945 IC50 10.0 nM
O=C(Nc1cnccc1OCC(F)(F)F)c1ccnc(Nc2ccc(C(F)(F)F)cc2)c1 CHEMBL5434002 IC50 10.0 nM
Cn1cc(/C=C2\Oc3cccc(O)c3C2=O)c2c(-c3ccc(C(=O)NCCO)cc3)ccnc21 CHEMBL1092754 IC50 10.6 nM
CCCC(=O)Nc1n[nH]c2ncc(-c3cccnc3)cc12 CHEMBL407002 IC50 11.0 nM
O=C(CCCN1CCCC1)Nc1n[nH]c2nnc(-c3ccccc3)cc12 CHEMBL261441 IC50 11.0 nM
O=C(Nc1n[nH]c2nc(-c3cccc(O)c3)ccc12)C1CC1 CHEMBL408019 IC50 12.0 nM
CN1CCC(C(=O)Nc2n[nH]c3nc(-c4ccc(O)cc4)ccc23)CC1 CHEMBL410926 IC50 12.0 nM
COC(=O)c1ccc(CSc2nnc(-c3ccc4c(c3)OCCO4)o2)cc1 CHEMBL2064520 IC50 12.0 nM
NC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCCC1CCN(Cc2ccc(F)cc2)CC1 CHEMBL4747992 IC50 12.0 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2c(F)ccc(F)c12 CHEMBL2001987 pKi 12.59 nM
Cn1cc(Nc2ncc(Br)c(Nc3ccccc3C(N)=O)n2)cn1 CHEMBL1994669 pKi 12.59 nM
COc1cc(OC)cc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)c1 CHEMBL2002613 pKi 12.59 nM
O=C(O)/C=C\c1ccc(Nc2ncc3nnn(-c4ccccc4)c3n2)cc1 CHEMBL255735 IC50 13.0 nM
COc1ccccc1C1C2=C(CC(C)(C)CC2=O)Nc2n[nH]c(C(F)(F)F)c21 CHEMBL3673985 IC50 13.0 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1 CHEMBL3301610 Kd apparent 13.0 nM
O=C1NCCC12CCN(c1c(Cl)cncc1-c1cc3ccccc3o1)CC2 CHEMBL4777349 Ki 13.0 nM
O=C(Nc1n[nH]c2nc(-c3ccco3)c(Br)cc12)C1CCN(Cc2ccccc2)C1 CHEMBL317657 IC50 14.0 nM
COc1ccccc1C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O CHEMBL156277 IC50 14.0 nM
O=C(Nc1n[nH]c2cc(-c3ccc(O)cc3)ccc12)C1CC1 CHEMBL260163 IC50 15.0 nM
N#Cc1cccc(CSc2nnc(-c3ccc4c(c3)OCO4)o2)c1 CHEMBL2064516 IC50 15.0 nM
N#Cc1ccc(CSc2nnc(-c3ccc4c(c3)OCO4)o2)cc1 CHEMBL2064517 IC50 15.0 nM
COC[C@H]1COc2ccc(-c3nnc(SCc4ccc(-c5ccccc5C#N)cc4)o3)cc2O1 CHEMBL2064539 IC50 15.0 nM
O=[N+]([O-])c1cccc(-c2ccc(CSc3nnc(-c4ccc5c(c4)OCO5)o3)cc2)c1 CHEMBL2391120 IC50 15.0 nM
O=[N+]([O-])c1cccc(-c2ccc(CSc3nnc(-c4ccc5c(c4)OCCO5)o3)cc2)c1 CHEMBL2391128 IC50 15.0 nM
O=C(Nc1cnccc1-c1cc(F)ccc1F)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5286049 IC50 15.0 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL1972158 pKi 15.85 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2cc(OC(F)F)ccc12 CHEMBL1981215 pKi 15.85 nM
Cc1n[nH]c2c1C(c1ccccc1F)C1=C(CC(C)(C)CC1=O)N2 CHEMBL1966703 pKi 15.85 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc([N+](=O)[O-])cc2)n1 CHEMBL242865 pKi 15.85 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 15.85 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2cc(Cl)ccc12 CHEMBL1981744 pKi 15.85 nM
CCS(=O)(=O)c1ccc(-c2cncc3sc(C(N)=O)cc23)cc1 CHEMBL2000104 pKi 15.85 nM
c1ccc(Cn2nnc(-c3ccc4[nH]ncc4c3)c2C2CC2)cc1 CHEMBL1975418 pKi 15.85 nM
O=C(Nc1n[nH]c2nc(-c3nccs3)c(Br)cc12)C1CCCC1 CHEMBL406644 IC50 16.0 nM
CC(=O)Nc1cc(-c2nnc(SCc3cccc(C#N)c3)o2)ccn1 CHEMBL2391101 IC50 17.0 nM
CCN1CCC(CC(=O)Nc2n[nH]c3nc(-c4cccs4)c(Br)cc23)CC1 CHEMBL101747 IC50 18.0 nM
CCCC(=O)Nc1n[nH]c2ncc(-c3ccccc3F)cc12 CHEMBL407373 IC50 18.0 nM
Nc1nccc(C(=O)Nc2cnccc2N2CCC(F)(F)CC2)n1 CHEMBL5430845 IC50 18.0 nM
CC(C)C(=O)Nc1n[nH]c2ncc(-c3ccccc3)cc12 CHEMBL261596 IC50 19.0 nM
N#Cc1ccccc1-c1ccc(CSc2nnc(-c3ccncc3)o2)cc1 CHEMBL2064536 IC50 19.0 nM
COc1ccc(-c2ccc(CSc3nnc(-c4ccc5c(c4)OCCO5)o3)cc2)cc1 CHEMBL2391126 IC50 19.0 nM
COc1ccccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O CHEMBL4875188 IC50 19.0 nM
CC(C)(C)c1ccc(-c2ccncc2NC(=O)c2ccnc(NC(=O)C3CC3)c2)cc1 CHEMBL5278847 IC50 19.0 nM
O=C(Nc1cnccn1)Nc1ccnc2c(F)cc(F)cc12 CHEMBL1967336 pKi 19.95 nM
CC(C)Nc1c(-c2ccc3[nH]ncc3c2)nc2ncccn12 CHEMBL1682553 pKi 19.95 nM
CCCC(=O)Nc1n[nH]c2nc3ccccc3cc12 CHEMBL1967564 pKi 19.95 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(F)c2)n1 CHEMBL243298 pKi 19.95 nM
COc1cccc(C(C)NC(=O)c2cc(C)c(-c3ccc4[nH]nc(C)c4c3)s2)c1 CHEMBL1997534 pKi 19.95 nM
O=c1nc(-c2ccc3[nH]ncc3c2)cc(-c2ccccc2)[nH]1 CHEMBL526133 pKi 19.95 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2c(C(F)(F)F)cccc12 CHEMBL1980142 pKi 19.95 nM
NC(=O)c1cc2c(-c3ccc(F)cc3F)cncc2s1 CHEMBL1975787 pKi 19.95 nM
CCCC(=O)Nc1n[nH]c2ncc(-c3cccc(F)c3)cc12 CHEMBL263907 IC50 20.0 nM
O=C(O)CCc1ccc(Nc2ncc3nnn(-c4ccccc4)c3n2)cc1 CHEMBL404565 IC50 20.0 nM
CC(=O)Nc1cc(-c2nnc(SCc3ccccc3)o2)ccn1 CHEMBL2391100 IC50 20.0 nM
CCN1CCN(CCCC(=O)Nc2n[nH]c3nc(-c4cccc(O)c4)ccc23)CC1 CHEMBL407730 IC50 21.0 nM
CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(-c4ccncc4)cc3)n2)c(=O)c1=O CHEMBL2205426 Ki 21.0 nM
CCOc1ccccc1/C=N/NC(=O)c1nnn(-c2nonc2N)c1CN1CCCCCC1 CHEMBL1970835 AC50_uM 21.9 nM
CN(C)CCC(=O)Nc1n[nH]c2nnc(-c3ccccc3)cc12 CHEMBL1242556 IC50 22.0 nM
O=C1OC(Nc2ncc3nnn(-c4ccccc4)c3n2)c2ccccc21 CHEMBL253956 IC50 23.0 nM
O=C(NC1CCNCC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl CHEMBL445813 Kd 23.0 nM
O=C(Nc1n[nH]c2nc(-c3ccc(O)cc3)c(-c3ccccc3)cc12)C1CC1 CHEMBL427909 IC50 24.0 nM
Cc1cccc(-c2[nH]c(-c3ccnc(N)n3)cc2C(N)=O)c1C CHEMBL1964290 pKi 25.12 nM
NC(=O)c1cccc2c1Nc1nnc(Cl)cc1C(=O)N2 CHEMBL1968070 pKi 25.12 nM
NC(=O)c1cc2c(-c3ccc(Br)c(F)c3F)cncc2s1 CHEMBL1999918 pKi 25.12 nM
O=c1nc(-c2cc3c(Oc4ccc(I)cc4)cncc3s2)[nH]o1 CHEMBL497151 pKi 25.12 nM
COc1ccc(CNC(=O)Nc2ncc([N+](=O)[O-])s2)cc1 CHEMBL259850 pKi 25.12 nM
O=C(Nc1cnccn1)Nc1ccnc2cc(C(F)(F)F)ccc12 CHEMBL2003817 pKi 25.12 nM
NC(COc1cncc(-c2cc3ccncc3s2)c1)Cc1c[nH]c2ccccc12 CHEMBL1966524 pKi 25.12 nM
O=C1NC(=O)C(c2cccc([N+](=O)[O-])c2)=C1Nc1ccc(Cl)c(C(=O)O)c1 CHEMBL156379 IC50 26.0 nM
CCCC(=O)Nc1n[nH]c2ncc(-c3ccccc3Cl)cc12 CHEMBL407003 IC50 27.0 nM
O=[N+]([O-])c1ccccc1-c1ccc(CSc2nnc(-c3ccncc3)o2)cc1 CHEMBL2391133 IC50 27.0 nM
Cc1nccc(-c2ccc(C(=O)N3CCOCC3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3701062 IC50 27.0 nM
O=C1NC(=O)C(c2ccccc2[N+](=O)[O-])=C1Nc1ccc(Cl)c(C(=O)O)c1 CHEMBL160586 IC50 28.0 nM
CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 CHEMBL296468 Kd 28.0 nM
O=C1NC(=O)C(c2cccc(Cl)c2)=C1Nc1ccc(O)c(Cl)c1 CHEMBL160333 IC50 28.0 nM
CC(C)CC(=O)Nc1n[nH]c2c1CN(C(=O)C1CCN(C)CC1)C2(C)C CHEMBL1230607 Kd apparent 29.0 nM
Cc1nc(C2CCOCC2)nc(Nc2n[nH]c3ncc(F)cc23)c1C CHEMBL3652542 IC50 30.0 nM
Cc1cc(Nc2n[nH]c3ccc(F)cc23)nc(C2CCOCC2)n1 CHEMBL3652546 IC50 30.0 nM
Cc1cc(-c2ccccc2Cl)nc(Nc2n[nH]c3ncc(F)cc23)c1C CHEMBL3661032 IC50 30.0 nM
Cc1ccncc1NC(=O)c1ccnn2c(NCC3CC3)cnc12 CHEMBL5284564 IC50 30.0 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3I)cc12 CHEMBL1975128 pKi 31.62 nM
CCCS(=O)(=O)Nc1ccc(-c2ccc3[nH]nc(NC(=O)CC)c3c2)cc1 CHEMBL1972221 pKi 31.62 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1F CHEMBL1981079 pKi 31.62 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(OC(F)(F)F)c4)c3)cc12 CHEMBL1965836 pKi 31.62 nM
Nc1n[nH]c2nnc(-c3ccccc3)c(-c3ccccc3)c12 CHEMBL260135 pKi 31.62 nM
OC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1991674 pKi 31.62 nM
O=C(O)c1ccc(Nc2ncc3nnn(-c4ccccc4)c3n2)cc1 CHEMBL402932 IC50 32.0 nM
C=CCOC(=O)c1cc(-c2ccc(/C=C3/NC(=S)NC3=O)o2)ccc1Cl CHEMBL4568120 IC50 33.0 nM
CNCc1ccc(-c2cc(-c3nc(-c4ccc(S(=O)(=O)C(C)C)cc4)cnc3N)on2)cc1 CHEMBL3989870 Ki 33.0 nM
O=C(O)c1ccc(Nc2ncc([N+](=O)[O-])c(NC34CC5CC(CC(C5)C3)C4)n2)cc1 CHEMBL253748 IC50 34.0 nM
Cn1cc(C2=C(c3ccc(Cl)cc3Cl)C(=O)NC2=O)c2ccccc21 CHEMBL102714 IC50 34.0 nM
O=C(Nc1cccnc1F)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5291070 IC50 34.0 nM
O=C(Nc1n[nH]c2cc(-c3ccoc3)ccc12)C1CC1 CHEMBL260243 IC50 35.0 nM
Fc1cc(F)cc(-c2ccc(CSc3nnc(-c4ccc5c(c4)OCCO5)o3)cc2)c1 CHEMBL2391124 IC50 35.0 nM
O=C(Nc1n[nH]c2nc(-c3ccccc3O)ccc12)C1CC1 CHEMBL260663 IC50 36.0 nM
COC(=O)C1=C(Nc2ccccc2Cl)O/C(=C\c2c[nH]c3ncccc23)C1=O CHEMBL4089159 IC50 37.0 nM
O=C(O)CCc1ccc(Nc2ncc([N+](=O)[O-])c(NC34CC5CC(CC(C5)C3)C4)n2)cc1 CHEMBL404175 IC50 38.0 nM
O=C(Nc1n[nH]c2nc(-c3cccs3)c(Br)cc12)C1CC1 CHEMBL260231 IC50 39.0 nM
CCOc1ccccc1/C=N/NC(=O)c1nnn(-c2nonc2N)c1CN1CCC(C)CC1 CHEMBL1904855 AC50 39.2 nM
O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c1nc(N2CCNCC2)nc2ccccc12 CHEMBL1996510 pKi 39.81 nM
CC(C)N(C)C(=O)c1c(-c2ccc3[nH]ncc3c2)nnn1Cc1ccccc1 CHEMBL1969561 pKi 39.81 nM
O=C(Nc1cnccn1)Nc1ccnc2ccccc12 CHEMBL1981720 pKi 39.81 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2cc(F)c(F)cc12 CHEMBL1981792 pKi 39.81 nM
COc1ccc(-c2cc3nccn3c(Nc3ncccc3C(N)=O)n2)cc1OC CHEMBL1190711 pKi 39.81 nM
CS(=O)(=O)c1ccc(-c2cncc3sc(C(N)=O)cc23)cc1 CHEMBL1972362 pKi 39.81 nM
NC(=O)c1cc2c(-c3cccc(F)c3)cncc2s1 CHEMBL1971017 pKi 39.81 nM
CC#Cc1ccc2nccc(NC(=O)Nc3cccc(C(F)(F)F)n3)c2c1 CHEMBL2007375 pKi 39.81 nM
N#Cc1cccc(NC(=O)Nc2ccnc3cc(C(F)(F)F)ccc23)n1 CHEMBL1968868 pKi 39.81 nM
COCCN1CCC(CNC(=O)c2n[nH]c3ccc(-c4cccc(F)c4F)cc23)CC1 CHEMBL3735506 IC50 40.0 nM
O=C(Nc1n[nH]c2cc(-c3ccc4[nH]ccc4c3)ccc12)C1CC1 CHEMBL261659 IC50 42.0 nM
NC(=O)c1cc(F)ccc1-c1ccc(CSc2nnc(-c3ccc4c(c3)OCCO4)o2)cc1 CHEMBL3632824 IC50 42.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 42.0 nM
CCC(=O)Nc1n[nH]c2ncc(-c3ccccc3)cc12 CHEMBL406701 IC50 43.0 nM
O=C1NCCC12CCN(c1c(Cl)cncc1-c1cc3ccccc3s1)CC2 CHEMBL4791586 Ki 43.0 nM
N#Cc1ncccc1NC(=O)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5269039 IC50 43.0 nM
N#Cc1ccc(CSc2nnc(-c3ccc4c(c3)OCCO4)o2)cc1 CHEMBL2064519 IC50 45.0 nM
COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(C)cc3)c3ccccc23)ccn1 CHEMBL3695569 IC50 45.0 nM
COc1cc(F)ccc1-c1ncnc(Nc2cccc(C[S@](C)(=N)=O)c2)n1 CHEMBL4439321 IC50 45.0 nM
N#Cc1cccc(-c2ccc(CSc3nnc(-c4ccncc4)o3)cc2)c1 CHEMBL2391132 IC50 46.0 nM
COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(S(C)(=O)=O)CC2)nc1N CHEMBL384304 IC50 46.0 nM
N=C1NC(=O)/C(=C\c2ccc(-c3cccc([N+](=O)[O-])c3)o2)S1 CHEMBL4455512 IC50 49.0 nM
O=C(Nc1n[nH]c2cc(-c3ccco3)ccc12)C1CC1 CHEMBL421207 IC50 50.0 nM
CCc1nc2c(c3cc(OC)c(OC)cc13)C(=O)NC2=O CHEMBL2003524 pKi 50.12 nM
NC(=O)c1cc2c(-c3ccc(Br)cc3)cncc2s1 CHEMBL1978195 pKi 50.12 nM
Cc1cc(Nc2nc(Cl)cc(NCc3ccccc3)n2)n[nH]1 CHEMBL2005449 pKi 50.12 nM
Nc1nonc1-n1nnc(C(=O)NN=Cc2cccs2)c1-c1cccs1 CHEMBL1975256 pKi 50.12 nM
CCn1c(-c2nonc2N)nc2cnc(Oc3cccc(NC(=O)c4ccc(OCCN5CCOCC5)cc4)c3)cc21 CHEMBL220241 pKi 50.12 nM
Nc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL2007574 pKi 50.12 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(C)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1984162 pKi 50.12 nM
CCCC(=O)Nc1nn(C(=O)CC)c2nc3ccccc3cc12 CHEMBL1970913 pKi 50.12 nM
NC(=O)Cn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL1985095 pKi 50.12 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 50.12 nM
CCc1ccc2c(NC(=O)Nc3cccc(C(F)(F)F)n3)ccnc2c1 CHEMBL1986756 pKi 50.12 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(Cl)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1987054 pKi 50.12 nM
COc1cc2c(cc1F)C(c1ccccc1Cl)=Nc1c(n[nH]c1C)N2 CHEMBL1980391 pKi 50.12 nM
Fc1cc(F)cc(-c2ccc(CSc3nnc(-c4ccc5c(c4)OCO5)o3)cc2)c1 CHEMBL2391117 IC50 51.0 nM
c1ccc(-c2ccc(CSc3nnc(-c4ccc5c(c4)OCCO5)o3)cc2)cc1 CHEMBL2391123 IC50 51.0 nM
c1ccc(-c2ccc(CSc3nnc(-c4ccncc4)o3)cc2)cc1 CHEMBL2391099 IC50 52.0 nM
COCC1COc2ccc(-c3nnc(SCc4ccc(-c5ccccc5C#N)cc4)o3)cc2O1 CHEMBL2064537 IC50 54.0 nM
Cc1ncc(-c2ccnc(Nc3ccc(S(C)(=O)=O)cc3)n2)n1C(C)C CHEMBL488436 Kd apparent 55.0 nM
CCCC(=O)Nc1n[nH]c2ncc(-c3ccccc3)cc12 CHEMBL258701 IC50 56.0 nM
OC12CC3CC(C1)CC(Nc1nc(N[C@H]4CC[C@H](O)CC4)ncc1C(F)(F)F)(C3)C2 CHEMBL255905 IC50 61.0 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 63.1 nM
O=C1NCCc2[nH]c(-c3ccncc3)cc21 CHEMBL225519 pKi 63.1 nM
NC(=O)c1cc2c(-c3ccc(F)cc3)cncc2s1 CHEMBL1974310 pKi 63.1 nM
O=c1[nH]c2sc3c(c2c2nc(-c4ccncc4)nn12)CCCC3 CHEMBL1966808 pKi 63.1 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2ccc(Cl)cc12 CHEMBL1967513 pKi 63.1 nM
COc1ccc(CNc2c(Nc3ccc4[nH]ncc4c3)c(=O)c2=O)cc1 CHEMBL1992536 pKi 63.1 nM
c1cnc2nc(-c3ccc4[nH]ncc4c3)c(NC3CCCCC3)n2c1 CHEMBL1682552 pKi 63.1 nM
Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCC#N)c4c21)CNC3=O CHEMBL302449 pKi 63.1 nM
O=C(O)c1ccc(Nc2ncc3nnn(C45CC6CC(CC(O)(C6)C4)C5)c3n2)cc1 CHEMBL257575 IC50 66.0 nM
CC[C@@]1(c2ccccc2)C2=C(CC(C)(C)CC2=O)Nc2n[nH]cc21 CHEMBL4438334 IC50 66.0 nM
CN1CC=C(c2c(O)cc(O)c3c(=O)cc(-c4ccc(Sc5nc6ccccc6n5C)cc4Cl)oc23)CC1 CHEMBL4788045 IC50 70.0 nM
O=C(O)COc1ccc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3)n2)cc1 CHEMBL402969 IC50 74.0 nM
Cc1n[nH]c2ccc(-c3nnc4n3[C@H](c3ccc(Cl)cc3)CC4)nc12 CHEMBL5416758 Kd 74.0 nM
O=C(Nc1n[nH]c2nc(-c3ccccc3)c(Br)cc12)C1CC1 CHEMBL259270 IC50 75.0 nM
O=C1NC(=O)C(c2cccc(Cl)c2)=C1Nc1ccc(Cl)c(C(=O)O)c1 CHEMBL156987 IC50 76.0 nM
N#Cc1ccc(-c2ccc(CSc3nnc(-c4ccncc4)o3)cc2)cc1 CHEMBL2390958 IC50 77.0 nM
O=C1NC(=O)C(c2ccccc2[N+](=O)[O-])=C1Nc1ccc(O)c(Cl)c1 CHEMBL322970 IC50 78.0 nM
O=C(NCc1ccccc1)Nc1ncc([N+](=O)[O-])s1 CHEMBL1964644 pKi 79.43 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(-c4ccccc4)c3n2)c1 CHEMBL1988163 pKi 79.43 nM
COc1cc2cnc3c(c2cc1OC)C(=O)NC3=O CHEMBL1982506 pKi 79.43 nM
NC(=O)c1cccc(-c2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982957 pKi 79.43 nM
CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL1084546 pKi 79.43 nM
O=C1Nc2ccccc2Nc2nnc(I)cc21 CHEMBL1977346 pKi 79.43 nM
N#Cc1ccc2c(c1)C(c1ccc3c(n1)CCCC3O)C(=O)N2 CHEMBL1985681 pKi 79.43 nM
O=C(O)c1ccc(Nc2ncc3nnn(C45CC6CC(CC(C6)C4)C5)c3n2)cc1 CHEMBL257577 IC50 80.0 nM
N#Cc1cc2c(NC(=O)C3CC3)n[nH]c2nc1-c1ccccc1 CHEMBL261881 IC50 87.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 87.0 nM
OC12CC3CC(C1)CC(Nc1nc(N[C@H]4CC[C@H](O)CC4)ncc1Br)(C3)C2 CHEMBL403385 IC50 91.0 nM
N#Cc1cccc(CSc2nnc(-c3ccc4c(c3)OCCO4)o2)c1 CHEMBL2064518 IC50 95.0 nM
O=C(O)COc1ccc(Nc2ncc3nnn(C45CC6CC(CC(O)(C6)C4)C5)c3n2)cc1 CHEMBL254350 IC50 96.0 nM
O=C(Nc1n[nH]c2nc(-c3nccs3)c(Br)cc12)C1CC1 CHEMBL261690 IC50 99.0 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3ccccc3)cc12 CHEMBL261366 IC50 99.0 nM
COc1cc(F)ccc1-c1ccnc(NC(=O)C2CCC(NC(C)=O)C2)c1 CHEMBL3673435 IC50 99.0 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 100.0 nM
c1ccc(Cn2cc(-c3ccc4[nH]ncc4c3)nn2)cc1 CHEMBL1682345 pKi 100.0 nM
COc1ccc2c(c1)C(=Cc1c[nH]cn1)C(=O)N2 CHEMBL2002649 pKi 100.0 nM
O=C(Cc1ccc(Cl)cc1)Nc1[nH]nc2c1CCC2 CHEMBL2003482 pKi 100.0 nM
NC(=O)c1cc2c(Oc3ccc(Br)cc3)cncc2s1 CHEMBL116070 pKi 100.0 nM
COCc1nnn(-c2nonc2N)c1C(=O)NN=C(C)c1ccc(O)cc1O CHEMBL1991180 pKi 100.0 nM
c1cnc2nc(-c3ccc4[nH]ncc4c3)cn2c1 CHEMBL1682540 pKi 100.0 nM
CCCCNc1nc(N)c(C(=O)c2ccccc2)s1 CHEMBL2007479 pKi 100.0 nM
O=C1Nc2ccccc2Nc2nnc(Cl)cc21 CHEMBL1968850 pKi 100.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccc(Cl)c(Cl)c4)c3)cc12 CHEMBL1991063 pKi 100.0 nM
N#Cc1c(O)[nH]c(=O)c2c(=N)oc3ccc(Cl)cc3c12 CHEMBL1973711 pKi 100.0 nM
COc1cccc(C(C)NC(=O)c2ccc(-c3ccncc3F)cc2OC)c1 CHEMBL1991188 pKi 100.0 nM
COc1cc(/C=N/Nc2ncnc3c2cnn3-c2ccccc2)ccc1O CHEMBL63803 IC50 100.0 nM
c1cc(-c2nnn[nH]2)ccc1CSc1nnc(-c2ccc3c(c2)OCO3)o1 CHEMBL2064522 IC50 107.0 nM
Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cc(Cl)cnc12 CHEMBL4552628 IC50 110.0 nM
COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)cc(NS(C)(=O)=O)c4OC)c4ccccc34)ccn2)ccc1C(=O)O CHEMBL3915286 IC50 115.0 nM
Cc1n[nH]c2ccc(-c3nnc(C)n3Cc3ccc(Cl)cc3)cc12 CHEMBL5414359 Kd 120.0 nM
O=C1Nc2ccc3ncsc3c2/C1=C/Nc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1276446 AC50_uM 121.0 nM
O=[N+]([O-])c1cnc(N[C@H]2CC[C@H](O)CC2)nc1NC12CC3CC(CC(O)(C3)C1)C2 CHEMBL404174 IC50 123.0 nM
O[C@H]1CC[C@H](Nc2ncc3nnn(-c4ccccc4)c3n2)CC1 CHEMBL255948 IC50 123.0 nM
COc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3n2)c1 CHEMBL406620 IC50 125.0 nM
CCCn1c(C2CCNCC2)nc(-c2ccc(Cl)c(Cl)c2)c1-c1ccnc(NC2CCCCC2)n1 CHEMBL437747 pKi 125.89 nM
COCCN(C)C(=O)c1c(-c2ccc3[nH]ncc3c2)nnn1Cc1ccccc1 CHEMBL1986970 pKi 125.89 nM
NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(-c3ccncc3)ccc2c1=O CHEMBL340384 pKi 125.89 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 125.89 nM
Cc1ccccc1-c1c(-c2ccc3[nH]nc(N)c3c2)nnn1Cc1ccccc1 CHEMBL2000029 pKi 125.89 nM
Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1682346 pKi 125.89 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL1970903 pKi 125.89 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1 CHEMBL4550702 IC50 130.0 nM
OC12CC3CC(C1)CC(Nc1nc(N[C@H]4CC[C@H](O)CC4)ncc1Cl)(C3)C2 CHEMBL257370 IC50 133.0 nM
O=C(Nc1n[nH]c2nc(-c3ccco3)ccc12)C1CC1 CHEMBL101804 IC50 141.0 nM
O=C1NC(=S)N/C1=C/c1ccc(-c2cccc(C(=O)O)c2)o1 CHEMBL4526685 IC50 145.0 nM
COc1ccc(C2=C(Nc3cccc(Cl)c3)C(=O)NC2=O)cc1 CHEMBL158208 IC50 156.0 nM
NC1CCC(Nc2nccc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1966628 pKi 158.49 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 158.49 nM
O=c1cc(-c2ccncc2)nc(NC2CCCCC2)[nH]1 CHEMBL1958401 pKi 158.49 nM
Cc1c(-c2ccc3[nH]nc(N)c3c2)nnn1Cc1ccccc1 CHEMBL1989646 pKi 158.49 nM
CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccccc3n2)CC1 CHEMBL565612 pKi 158.49 nM
COc1ccc(C=NNc2ncnc3c2[nH]c2ccccc23)cc1OC CHEMBL1974664 pKi 158.49 nM
Cc1cc(Cl)ccc1NC(=S)NNC(=O)C(O)(c1ccccc1)c1ccccc1 CHEMBL1988173 pKi 158.49 nM
NC(=O)c1cc2c(-c3cc(C(F)(F)F)cc(C(F)(F)F)c3)cncc2s1 CHEMBL2002322 pKi 158.49 nM
CCCS(=O)(=O)Nc1ccc(-c2ccc3[nH]nc(NC(C)=O)c3c2)cc1 CHEMBL1973893 pKi 158.49 nM
NCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL590109 pKi 158.49 nM
CSc1ccc2nc3c(c(Cl)c2c1)CCNC3=O CHEMBL1985074 pKi 158.49 nM
NC(=O)c1cc2c(-c3ccccc3)cncc2s1 CHEMBL1999556 pKi 158.49 nM
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=O)c1c(F)cccc1F CHEMBL191003 pKi 158.49 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 158.49 nM
CCCOC(=O)c1cc(-c2ccc(/C=C3/NC(=S)NC3=O)o2)ccc1Cl CHEMBL4452888 IC50 159.0 nM
COc1cc(F)ccc1-c1ccnc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)c1 CHEMBL3673434 IC50 160.0 nM
Cc1[nH]nc2c1[C@H](c1ccccc1)C1=C(CC(C)(C)CC1=O)N2 CHEMBL3673983 IC50 161.0 nM
Cc1ccc(-c2ccc(/C=C3/SC(=N)NC3=O)o2)c([N+](=O)[O-])c1 CHEMBL4561377 IC50 162.0 nM
Nc1nc(Nc2ccccc2)sc1C(=O)c1ccccc1 CHEMBL561114 AC50_uM 168.0 nM
CCCC(=O)Nc1n[nH]c2ncc(-c3ccc4ccccc4c3)cc12 CHEMBL406062 IC50 169.0 nM
O=[N+]([O-])c1cnc(N[C@H]2CC[C@H](O)CC2)nc1Nc1ccccc1 CHEMBL256517 IC50 172.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5c(c4)C(=O)NC5)n3)c3ccccc23)n(-c2ccc(OCCN3CCOCC3)cc2)n1 CHEMBL3890213 IC50 184.0 nM
COc1ccccc1C1=C(N2CCc3ccccc32)C(=O)NC1=O CHEMBL160585 IC50 187.0 nM
CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3cnn4c3CC(C)(C)C4)c(Cl)cn2)C1 CHEMBL4462530 IC50 187.0 nM
CCOC(=O)C1=C(NN2CCN(CC(F)(F)F)CC2)O/C(=C\c2c[nH]c3ncccc23)C1=O CHEMBL4868568 IC50 189.0 nM
COC[C@@H]1COc2ccc(-c3nnc(SCc4ccc(-c5ccccc5C#N)cc4)o3)cc2O1 CHEMBL2064538 IC50 195.0 nM
N#Cc1ccc(-c2ccc(CSc3nnc(-c4ccc5c(c4)OCCO5)o3)cc2)cc1 CHEMBL2391127 IC50 195.0 nM
O=C1CCCN1Cc1ccc2c(c1)[nH]c(=O)c1cccn12 CHEMBL539474 pKi 199.53 nM
O=c1c(NCc2ccc(Cl)c(Cl)c2)c(Nc2ccncc2)c1=O CHEMBL1975900 pKi 199.53 nM
CC(C)n1nnc2ccc(-c3c(-c4ccc(F)cc4F)nc4occn34)cc21 CHEMBL1969126 pKi 199.53 nM
NC(=O)c1cc2c(Oc3cccc(F)c3)cncc2s1 CHEMBL1964777 pKi 199.53 nM
Nc1ncnc2c1sc1ncnc(N)c12 CHEMBL1976090 pKi 199.53 nM
Cn1cc(-c2cc3nc(Br)cnc3[nH]2)c2cc(F)ccc21 CHEMBL1993335 pKi 199.53 nM
COc1cccc(C(C)NC(=O)N2CC=C(c3c[nH]c4ncccc34)CC2)c1 CHEMBL1965845 pKi 199.53 nM
O=C1Nc2ccccc2Nc2nnccc21 CHEMBL1971801 pKi 199.53 nM
COc1ccc(-n2nc(C(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]nc(OCCN6CCOCC6)c5c4)n3)c3ccccc23)cc1 CHEMBL3927937 IC50 203.0 nM
COC(=O)COc1ccc(Nc2ncc3nnn(-c4ccccc4)c3n2)cc1 CHEMBL404242 IC50 204.0 nM
N=C1NC(=O)/C(=C\c2ccc(-c3cccc(C(=O)O)c3)o2)S1 CHEMBL4572532 IC50 207.0 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL1802358 IC50 210.0 nM
C[C@@H](NC(=O)Nc1cc2[nH]ncc2c(CO)n1)c1ccccc1 CHEMBL4538174 IC50 210.0 nM
O=C(Nc1cccnc1O)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5274110 IC50 210.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 213.0 nM
O=C(Nc1n[nH]c2cc(-c3cccs3)ccc12)C1CC1 CHEMBL318522 IC50 215.0 nM
Cc1c(-c2ccc(/C=C3/SC(=N)NC3=O)o2)ccc([N+](=O)[O-])c1C CHEMBL4536515 IC50 227.0 nM
Cn1cc(-c2ccc(-c3cncc(Cl)c3N3CCC4(CCNC4=O)CC3)cc2)cn1 CHEMBL3408213 Ki 231.0 nM
O=C(Nc1n[nH]c2nc(-c3ccccc3)c(Cl)cc12)C1CC1 CHEMBL261883 IC50 234.0 nM
COc1ccc(-c2ccc(CSc3nnc(-c4ccncc4)o3)cc2)cc1 CHEMBL2391131 IC50 240.0 nM
Cc1n[nH]c2ccc(-c3nnc(C)n3Cc3ccc(C(F)(F)F)cc3)cc12 CHEMBL5396725 Kd 240.0 nM
CCCC(=O)Nc1n[nH]c2ncc(-c3cccc4ccccc34)cc12 CHEMBL260329 IC50 241.0 nM
N=C1NC(=O)/C(=C\c2ccc(-c3ccccc3Cl)o2)S1 CHEMBL4537545 IC50 242.0 nM
Cn1cc(C2=C(c3cn(C4CCN(Cc5ccccn5)CC4)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL300138 Kd apparent 246.0 nM
Cc1ccnc2[nH]c3cc(C(C)C)ccc3c(=O)c12 CHEMBL1989471 pKi 251.19 nM
COc1cccc(C(C)NC(=O)c2ccc(-c3ccncc3)c(C)c2)c1 CHEMBL1969049 pKi 251.19 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCc4cccc(F)c4)cc2NC3=O)ccc1O CHEMBL2000832 pKi 251.19 nM
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCCC4=O)c3)n2)c1 CHEMBL1991429 pKi 251.19 nM
NC(COc1cncc(-c2ccc3cnccc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL1981133 pKi 251.19 nM
NCC(NC(=O)c1ccc(-c2ccncc2)cc1)c1ccccc1 CHEMBL1990254 pKi 251.19 nM
CC(Nc1cncc(-n2cnc3ccc(C#N)cc32)n1)c1ccccc1F CHEMBL1977138 pKi 251.19 nM
CCCCOc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1996817 pKi 251.19 nM
CCN(CC)S(=O)(=O)c1cc(Nc2nccc(-c3ccnc(-c4ccc(NC(=O)NC)cc4)c3)n2)ccc1Cl CHEMBL2158866 IC50 260.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5c(c4)NC(=O)C5)n3)c3ccccc23)n(-c2ccc(OCCN3CCOCC3)nc2)n1 CHEMBL3986904 IC50 267.0 nM
O=C(O)c1ccc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3)n2)cc1 CHEMBL257188 IC50 270.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OC[C@H]3CCCNC3)c21 CHEMBL494089 Kd apparent 275.0 nM
COc1ccccc1Nc1nc(NCCO)nc(N)c1[N+](=O)[O-] CHEMBL1369106 AC50 276.0 nM
CC(C)c1cc(NC(=O)Nc2ccc(Oc3cc(Nc4ccc5[nH]ncc5c4)ncn3)c3ccccc23)n(-c2ccc(=O)n(CCO)c2)n1 CHEMBL3935126 IC50 278.0 nM
N=C1NC(=O)/C(=C\c2ccc(-c3cccc(Cl)c3)o2)S1 CHEMBL4558089 IC50 282.0 nM
COc1cccc(C(=O)c2sc(NC(C)C)nc2N)c1 CHEMBL1464354 AC50 288.0 nM
CC(=O)Nc1n[nH]c2ncc(-c3ccccc3)cc12 CHEMBL288448 IC50 291.0 nM
N=C1NC(=O)/C(=C\c2ccc(-c3ccc(Cl)c(Cl)c3)o2)S1 CHEMBL4592453 IC50 300.0 nM
CSc1nc(-c2ccc(F)cc2)c(-c2ccnc(NC(=O)C3CC3)c2)[nH]1 CHEMBL4474903 IC50 300.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]cnc5c4)n3)c3ccccc23)cc1 CHEMBL3919242 IC50 301.0 nM
Cc1ccc(-c2ccc(/C=C3/SC(=N)NC3=O)o2)cc1Cl CHEMBL4519366 IC50 301.0 nM
CCc1nc(-c2ccc(F)cc2)c(-c2ccnc(NC(=O)C3CC3)c2)[nH]1 CHEMBL4536012 IC50 301.0 nM
O=C1NC(=S)N/C1=C/c1ccc(-c2ccc(C(=O)O)cc2)o1 CHEMBL4452978 IC50 309.0 nM
Cc1nc2ccc(NS(=O)(=O)c3ccc(N)cc3)cc2nc1C CHEMBL2006263 pKi 316.23 nM
NC(COc1cncc(-c2cc3cnccc3s2)c1)Cc1c[nH]c2ccccc12 CHEMBL1972840 pKi 316.23 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCCNC(C)=O)cc2NC3=O)ccc1O CHEMBL1975500 pKi 316.23 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCOCC2)n1 CHEMBL1980253 pKi 316.23 nM
COc1ccccc1-c1ccnc(Nc2cccc(S(C)(=O)=O)c2)n1 CHEMBL1975903 pKi 316.23 nM
CCC(=O)Nc1ccc(C(=O)N2CCNCC2)c(O)c1 CHEMBL1988141 pKi 316.23 nM
O=C(NC(CO)c1ccccc1)c1ccc(-c2ccncc2)cc1 CHEMBL1974288 pKi 316.23 nM
O=C1NC(=S)SC1=C1C(=O)Nc2ccc(Br)cc21 CHEMBL2001920 pKi 316.23 nM
COc1cc(C=C(C#N)c2nc3ccccc3[nH]2)c(Br)cc1O CHEMBL1994241 pKi 316.23 nM
c1ccc(Cc2cn(-c3ccc4[nH]ncc4c3)nn2)cc1 CHEMBL1682341 pKi 316.23 nM
Cc1n[nH]c2ncc(C#N)c(-c3ccccc3)c12 CHEMBL1965495 pKi 316.23 nM
CN(C)C(=O)c1c(-c2ccc3[nH]ncc3c2)nnn1Cc1ccccc1 CHEMBL1996111 pKi 316.23 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccccc4)c3)cc12 CHEMBL2002726 pKi 316.23 nM
O=c1c(NCc2ccccc2F)c(Nc2ccncc2)c1=O CHEMBL1982361 pKi 316.23 nM
O=C(Nc1n[nH]c2cc(-c3ccc[nH]3)ccc12)C1CC1 CHEMBL260929 IC50 320.0 nM
N#Cc1cc(F)ccc1-c1ccc(CSc2nnc(-c3ccncc3)o2)cc1 CHEMBL2391098 IC50 324.0 nM
O=C(Nc1n[nH]c2cc(-c3ccsc3)ccc12)C1CC1 CHEMBL260928 IC50 329.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 329.0 nM
c1ccc(Nc2ncc3nnn(-c4ccccc4)c3n2)cc1 CHEMBL256518 IC50 330.0 nM
O=C(O)c1ccc(Nc2ncc3c(Cl)nn(-c4ccccc4)c3n2)cc1 CHEMBL253740 IC50 350.0 nM
CCCC(=O)Nc1n[nH]c2ncc(B3OC(C)(C)C(C)(C)O3)cc12 CHEMBL264162 IC50 356.0 nM
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 CHEMBL4569508 IC50 360.0 nM
Cc1cccc(C(=O)N[C@H]2C[C@@H](n3cnc(NC(=O)Cc4cccc5ccccc45)c3)C2)n1 CHEMBL583658 AC50_uM 361.0 nM
COc1cc(/C=N/Nc2ccc([N+](=O)[O-])cn2)cc(OC)c1O CHEMBL1884163 AC50 367.0 nM
O=C1NC(=S)N/C1=C/c1ccc(-c2ccc(Cl)c(Cl)c2)o1 CHEMBL4436862 IC50 370.0 nM
OC1(c2ccccc2)CSC(=S)N1Cc1ccncc1 CHEMBL4861930 IC50 370.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 380.0 nM
CN1CCC(C(=O)Nc2n[nH]c3nc(-c4ccccc4)c(Br)cc23)CC1 CHEMBL261882 IC50 383.0 nM
C=CCNc1nc(N)c([N+](=O)[O-])c(Nc2ccccc2OC)n1 CHEMBL1433424 AC50 388.0 nM
Ic1cccc(CSc2nnc(-c3ccncc3)o2)c1 CHEMBL288064 IC50 390.0 nM
Cc1ccnc(Nc2cc(C)nc(-c3ccccc3)n2)c1 CHEMBL1985367 pKi 398.11 nM
O=C(O)c1cc2c(-c3cccc(F)c3)cncc2s1 CHEMBL1974457 pKi 398.11 nM
OCC(CO)Nc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1992922 pKi 398.11 nM
Cc1cc(=O)n2ccc(CN(C)C)c(O)c2n1 CHEMBL1988581 pKi 398.11 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 398.11 nM
CSc1cnc2c(ccc3cnccc32)c1O CHEMBL2006933 pKi 398.11 nM
CCN(CC)C(=O)Nc1ccc2nc(-c3ccco3)c(-c3ccco3)nc2c1 CHEMBL1983195 pKi 398.11 nM
CCn1c(-c2nonc2N)nc2cncc(C(=O)N3CCC(N)C3)c21 CHEMBL1870106 pKi 398.11 nM
O=C(Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCCC4=O)c3)n2)c1)c1c(F)cccc1F CHEMBL2006715 pKi 398.11 nM
NC(COc1cncc(C=Cc2ccncc2)c1)Cc1c[nH]c2ccccc12 CHEMBL1974935 pKi 398.11 nM
NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1973720 pKi 398.11 nM
CC(NC(=O)c1ccc(-c2ccncc2)cc1)c1ccccc1 CHEMBL1999428 pKi 398.11 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 398.11 nM
COc1cc(-c2ccc3c(c2)Nc2ccc([N+](=O)[O-])cc2NC3=O)ccc1O CHEMBL1995740 pKi 398.11 nM
Cc1cnc(Nc2ccc(F)cc2Cl)nc1-c1c[nH]c(C(=O)N[C@H](CO)c2cccc(Cl)c2)c1 CHEMBL583042 Ki 400.0 nM
COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]nc(OCCN6CCOCC6)c5c4)n3)c3ccccc23)cc1 CHEMBL3950258 IC50 407.0 nM
C#Cc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)cc(NS(C)(=O)=O)c4OC)c4ccccc34)n2)cc(C(=O)NCCOCCOCCOC)c1 CHEMBL3681949 IC50 411.0 nM
O=C1NC(=S)N/C1=C/c1ccc(-c2ccc([N+](=O)[O-])cc2)o1 CHEMBL4566633 IC50 412.0 nM
CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCC[C@H]3CCO)nc12 CHEMBL2103840 IC50 414.0 nM
O=C(Nc1n[nH]c2nc(-c3ccccc3)c(-c3ccccc3)cc12)C1CC1 CHEMBL407958 IC50 415.0 nM
Nc1nonc1-n1nnc(C(=O)N/N=C/c2ccccc2F)c1-c1cccs1 CHEMBL1896181 AC50 422.0 nM
O=C(Nc1n[nH]c2nc(-c3ccccc3)ccc12)C1CC1 CHEMBL260344 IC50 425.0 nM
O=C(Nc1cc(-c2[nH]c(Cc3ccccc3)nc2-c2ccc(F)cc2)ccn1)C1CC1 CHEMBL4476724 IC50 428.0 nM
Nc1nc(NCCCN2CCOCC2)nc(Nc2cccc(Cl)c2)c1[N+](=O)[O-] CHEMBL1447858 AC50 429.0 nM
Nc1n[nH]c2ncc(-c3ccccc3)cc12 CHEMBL261439 IC50 430.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 430.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5c(c4)CS(=O)(=O)C5)n3)c3ccccc23)n(-c2ccc(OCCN3CCOCC3)cc2)n1 CHEMBL3914683 IC50 437.0 nM
Cc1ccc(-c2ccc(/C=C3/NC(=S)NC3=O)o2)c(Br)c1 CHEMBL4467604 IC50 440.0 nM
CCCC(=O)Nc1n[nH]c2ncc(-c3ccncc3)cc12 CHEMBL261264 IC50 443.0 nM
OC12CC3CC(C1)CC(n1nnc4cnc(N[C@H]5CC[C@H](O)CC5)nc41)(C3)C2 CHEMBL254155 IC50 444.0 nM
c1ccc(-c2noc(CSc3nnc(-c4ccncc4)o3)n2)cc1 CHEMBL4545000 IC50 451.0 nM
O=C(CN1C(=O)CCC1=O)Nc1cccc2c1C(=O)NC2=O CHEMBL1545694 AC50 459.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5ncsc5c4)n3)c3ccccc23)n(-c2ccc(OCCN3CCOCC3)cc2)n1 CHEMBL3979828 IC50 461.0 nM
O=C(Nc1cnccc1N1CCC(F)(F)CC1)c1ccncn1 CHEMBL5408273 IC50 470.0 nM
COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]nc(C(=O)N(C)C)c5c4)n3)c3ccccc23)cc1 CHEMBL3975188 IC50 472.0 nM
CCOc1cccc(-c2c(C(=O)N/N=C/c3sccc3C)nnn2-c2nonc2N)c1 CHEMBL1996263 AC50_uM 474.0 nM
NS(=O)(=O)c1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 CHEMBL407113 IC50 481.0 nM
COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5c(cnn5CCN5CCOCC5)c4)n3)c3ccccc23)cc1 CHEMBL3958953 IC50 485.0 nM
O=C(Nc1n[nH]c2cc(-c3ccccc3)ccc12)C1CC1 CHEMBL405021 IC50 498.0 nM
CCCCc1c(-c2ccc(O)cc2)[nH]c2nccnc12 CHEMBL75680 IC50 500.0 nM
COc1cccc(C(C)NC(=O)c2ccc(-c3ccncc3)c(F)c2)c1 CHEMBL2004934 pKi 501.19 nM
O=c1c(NCc2ccc(Cl)cc2)c(Nc2ccncc2)c1=O CHEMBL1980489 pKi 501.19 nM
NC(=O)c1cc2c(-c3ccc(Nc4nc5ccccc5o4)cc3)cnc(N)c2s1 CHEMBL1993904 pKi 501.19 nM
CCN1CCN(c2ccc(Nc3ncc(C#N)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1973516 pKi 501.19 nM
COc1ccc2c(c1)c(-c1cc3nc(Br)cnc3[nH]1)cn2C CHEMBL2005478 pKi 501.19 nM
CC(C)(C)Nc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1995211 pKi 501.19 nM
c1ccc(Nc2nc(-c3ccc4[nH]ncc4c3)cs2)cc1 CHEMBL1682545 pKi 501.19 nM
Cc1cccc(Nc2nccc(Nc3c(NC(C)C(C)(C)C)c(=O)c3=O)n2)c1 CHEMBL1969523 pKi 501.19 nM
COc1cccc(C(C)NC(=O)c2ccc(-c3ccncc3C)cc2)c1 CHEMBL1970217 pKi 501.19 nM
O=c1c(NCc2cccc(C(F)(F)F)c2)c(Nc2ccncc2)c1=O CHEMBL1979252 pKi 501.19 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 501.19 nM
O=c1c(NCc2ccc(Cl)cc2Cl)c(Nc2ccc3[nH]ncc3c2)c1=O CHEMBL1979554 pKi 501.19 nM
O=c1[nH]c2sccc2c2nc(-c3ccncc3)nn12 CHEMBL1968151 pKi 501.19 nM
CC(C)(C)NC(=O)c1ccc2nc3[nH]c4ccccc4c3nc2c1 CHEMBL1969264 pKi 501.19 nM
O=C(Nc1cccnc1)c1ccnn2c(NCC3CC3)cnc12 CHEMBL5266078 IC50 510.0 nM
O=C1c2ccccc2-c2onc3ccc(NCCCN4CCNC4)c1c23 CHEMBL1881885 AC50 520.0 nM
Nc1n[nH]c2nnc(-c3ccccc3)cc12 CHEMBL408634 IC50 530.0 nM
CC(=O)/N=C1/NC(=O)/C(=C\c2ccc(-c3ccc(C(=O)O)cc3)o2)S1 CHEMBL4442366 IC50 557.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5c(cnn5CCN5CCOCC5)c4)n3)c3ccccc23)n(-c2ccc(OCCN3CCOCC3)nc2)n1 CHEMBL3901628 IC50 569.0 nM
CN1C/C=C/CCOc2cccc(c2)-c2ccnc(n2)Nc2cccc(c2)C1 CHEMBL1944698 Kd apparent 579.0 nM
CSc1ccc(NC2=C(c3ccccc3Cl)C(=O)NC2=O)cc1 CHEMBL156563 Kd 580.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5c(cnn5CCN5CCOCC5)c4)n3)c3ccccc23)cc1 CHEMBL3962324 IC50 582.0 nM
Cc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(CN5CCCC5=O)c4)c4ccccc34)n2)cc2cn[nH]c12 CHEMBL3915981 IC50 589.0 nM
CN(C)Cc1c(C(=O)N/N=C/c2ccncc2)nnn1-c1nonc1N CHEMBL1903171 AC50 597.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5c(cnn5CCN5CCOCC5)c4)n3)c3ccccc23)n(-c2ccc(OCCN3CCOCC3)cc2)n1 CHEMBL3936603 IC50 597.0 nM
CC(C)(O)c1ccc(-c2cnc3[nH]c(=O)n(CC4CCCCC4)c3n2)cc1 CHEMBL1945950 IC50 600.0 nM
O=C1NC(=S)N/C1=C/c1ccc(-c2ccccc2Cl)o1 CHEMBL4456469 IC50 609.0 nM
O=C(OC[C@H]1O[C@@H](n2cnc3c(=O)[nH]cnc32)[C@H](O)[C@@H]1O)c1cc[nH]c1 CHEMBL4637966 IC50 610.0 nM
OC(COc1cncc(C=Cc2ccncc2)c1)Cc1c[nH]c2ccccc12 CHEMBL1993584 pKi 630.96 nM
CNC(=O)c1cc2c(-c3ccccc3F)n[nH]c2s1 CHEMBL1977681 pKi 630.96 nM
CCCCN(CCC#N)C(=O)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1983348 pKi 630.96 nM
Cc1ccc(CNc2c(Nc3ccncc3)c(=O)c2=O)cc1C CHEMBL1983449 pKi 630.96 nM
O=C1NCCc2[nH]c(-c3ccnc(C=Cc4ccccc4)c3)cc21 CHEMBL1997129 pKi 630.96 nM
COCOc1cccc(OCOC)c1-c1ccc(NS(C)(=O)=O)cc1C(=O)OC CHEMBL2004025 pKi 630.96 nM
CNC(=O)COc1ccc(Nc2nc(Nc3ccc(C)c(S(N)(=O)=O)c3)ncc2F)cc1 CHEMBL1978099 pKi 630.96 nM
N#Cc1ccc(-c2ccncc2)cc1NCc1ccccc1 CHEMBL1967992 pKi 630.96 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(Cc4ccccc4)c3n2)c1 CHEMBL1993424 pKi 630.96 nM
COc1cccc(C(C)NC(=O)c2ccc(-c3ccncc3)cc2)c1 CHEMBL1975121 pKi 630.96 nM
Cc1cc(-c2ccccc2)n(-c2cc(NN=Cc3ccco3)ncn2)n1 CHEMBL1999590 pKi 630.96 nM
NC(COc1cncc(-c2ccc3c(c2)CC(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL1967302 pKi 630.96 nM
COc1cccc(C(C)NC(=O)c2ccc(-c3ccncn3)cc2)c1 CHEMBL2004872 pKi 630.96 nM
O=C1Nc2cc(-c3ccc(O)cc3)ccc2C1=Cc1ccc[nH]1 CHEMBL1980329 pKi 630.96 nM
Cc1ccc(CNc2c(Nc3ccncc3)c(=O)c2=O)cc1 CHEMBL1994864 pKi 630.96 nM
NCC1CCC(CNc2nc(NCc3ccccc3Cl)ncc2[N+](=O)[O-])CC1 CHEMBL246970 pKi 630.96 nM
NC(=O)c1ccc(-c2c[nH]c3nccc(Cl)c23)cc1 CHEMBL1982711 pKi 630.96 nM
NC(COc1cncc(C=Cc2ccncc2)c1)Cc1ccccc1 CHEMBL1991846 pKi 630.96 nM
CC(=O)N1CCC(Nc2nccc(-c3c(-c4ccc(F)cc4)nc4occn34)n2)CC1 CHEMBL1986781 pKi 630.96 nM
O=C1NC(=O)c2c1c(-c1ccccc1Cl)cc1[nH]c3ccc(O)cc3c21 CHEMBL379975 pKi 630.96 nM
O=C(O)c1cc2c(-c3ccccc3)cncc2s1 CHEMBL1996390 pKi 630.96 nM
O=C(Nc1nc2ccccc2s1)c1cccc2c1CN(c1nc(C(=O)O)c(-c3ccc(CO)cc3)s1)CC2 CHEMBL1983980 pKi 630.96 nM
c1ccc2c(c1)nnn2Cc1cn(-c2ccc3[nH]ncc3c2)nn1 CHEMBL1966069 pKi 630.96 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]nnc5c4)n3)c3ccccc23)n(-c2ccc(OCCN3CCOCC3)cc2)n1 CHEMBL3899391 IC50 641.0 nM
Nc1nc2c(ncn2[C@@H]2O[C@H](COC(=O)c3cc[nH]c3)[C@@H](O)[C@H]2O)c(=O)[nH]1 CHEMBL4634615 IC50 670.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5c(c4)COC5)n3)c3ccccc23)n(-c2ccc(OCCN3CCOCC3)cc2)n1 CHEMBL3938312 IC50 686.0 nM
CCCC(=O)Nc1n[nH]c2nnc(-c3ccccc3)c(-c3ccccc3)c12 CHEMBL261127 IC50 691.0 nM
Cc1n[nH]c2ncc(C(=O)N3CCC[C@H]3c3ccc(Cl)cc3)cc12 CHEMBL3903492 IC50 691.0 nM
Nc1nc(NCCCN2CCOCC2)nc(Nc2cccc(F)c2)c1[N+](=O)[O-] CHEMBL1521195 AC50 698.0 nM
CCCCOC(=O)c1cc(-c2ccc(/C=C3/NC(=S)NC3=O)o2)ccc1Cl CHEMBL4444495 IC50 710.0 nM
Nc1nc2c(ncn2[C@@H]2O[C@H](COC(=O)c3ccc[nH]3)[C@@H](O)[C@H]2O)c(=O)[nH]1 CHEMBL4642516 IC50 710.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5scnc5c4)n3)c3ccccc23)n(-c2ccc(OCCN3CCOCC3)cc2)n1 CHEMBL3909641 IC50 730.0 nM
O=C(O)c1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccccc3)n2)cc1 CHEMBL256306 IC50 750.0 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1 CHEMBL428690 IC50 770.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5oc(=O)[nH]c5c4)n3)c3ccccc23)n(-c2ccc(OCCN3CCOCC3)cc2)n1 CHEMBL4110557 IC50 777.0 nM
Cc1cc(N2CCOCC2)cc2[nH]c(-c3c(NCC(O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL2005886 pKi 794.33 nM
Cn1cc(-c2cc3nc(Br)cnc3[nH]2)c2cc(C#N)ccc21 CHEMBL1978562 pKi 794.33 nM
CC(Nc1c(Nc2ccncc2)c(=O)c1=O)c1ccccc1 CHEMBL1966035 pKi 794.33 nM
O=C(NC(CO)c1cc(Cl)cc(Cl)c1)c1ccc(-c2ccncc2)cc1 CHEMBL2003341 pKi 794.33 nM
Cc1cc(O)ccc1-n1cc(C(=O)NN)c(=O)c2ccc(-c3ccncc3)cc21 CHEMBL2000894 pKi 794.33 nM
CN1CCC(c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)C(O)C1 CHEMBL422897 pKi 794.33 nM
c1ccc(Cc2cc(-c3ccc4[nH]ncc4c3)on2)cc1 CHEMBL1682357 pKi 794.33 nM
CN(C)C1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1969151 pKi 794.33 nM
COc1ccc(-c2cnc3c(Br)cnn3c2)cc1 CHEMBL443962 pKi 794.33 nM
CN1CCC(C(=O)n2nc(N)c3cc(-c4cn(Cc5ccccc5)nn4)ccc32)CC1 CHEMBL1978014 pKi 794.33 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCCCC2)n1 CHEMBL2006439 pKi 794.33 nM
COC(=O)c1cc2c(-c3cccc(F)c3)cncc2s1 CHEMBL2004072 pKi 794.33 nM
O=C(NN=Cc1cc(Br)c(O)c(Br)c1)Nc1ccccc1 CHEMBL1983575 pKi 794.33 nM
CN(C)c1ccc(-c2cc(-c3ccc([N+](=O)[O-])cc3)nc(NS(=O)(=O)c3ccc(N)cc3)n2)cc1 CHEMBL1980167 pKi 794.33 nM
O=C(Nc1cnc2[nH]cc(-c3ccccc3)c2c1)c1cccc(F)c1F CHEMBL1974416 pKi 794.33 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]ncc5c4)n3)c3ccccc23)n(-c2ccc(=O)n(CCO)c2)n1 CHEMBL3944099 IC50 827.0 nM
O=C(Nc1n[nH]c2cc(-c3cccc(F)c3)ccc12)C1CC1 CHEMBL261660 IC50 828.0 nM
O/N=C/c1cn(-c2ccccc2)nc1-c1cccnc1 CHEMBL1870845 AC50 828.0 nM
COc1ccc(-n2nc(C3CCOC3)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]ncc5c4)n3)c3ccccc23)cc1 CHEMBL3921479 IC50 837.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5c(c4)OCCO5)n3)c3ccccc23)n(-c2ccc(OCCN3CCOCC3)cc2)n1 CHEMBL3933807 IC50 848.0 nM
CCCC(=O)Nc1n[nH]c2ncc(-c3ccc(-c4ccccc4)cc3)cc12 CHEMBL261052 IC50 851.0 nM
O=C(Nc1cc(-c2[nH]c(SCc3ccccc3)nc2-c2ccc(F)cc2)ccn1)C1CC1 CHEMBL4546015 IC50 853.0 nM
O=C(Cc1ccc2ccccc2c1)Nc1cc(Cl)ccn1 CHEMBL4754904 IC50 860.0 nM
Cc1ccnc(NC(=O)Cc2ccc3ccccc3c2)c1 CHEMBL4781866 Kd 870.0 nM
COc1cc2c(cc1OC)CN(CC(=O)Nc1ccc3c(c1)/C(=C/c1cnc[nH]1)C(=O)N3)CC2 CHEMBL3091673 IC50 884.0 nM
Nc1ncnc2c1ncn2[C@@H]1O[C@H](COC(=O)c2ccc[nH]2)[C@@H](O)[C@H]1O CHEMBL4633057 IC50 890.0 nM
Nc1nccc(-c2c[nH]c3c(Br)ccc(O)c23)n1 CHEMBL296682 IC50 900.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5c(c4)CC(=O)N5C)n3)c3ccccc23)cc1 CHEMBL3975927 IC50 900.0 nM
Cc1ccc(-c2ccc(/C=C3/NC(=S)NC3=O)o2)cc1Cl CHEMBL4519757 IC50 904.0 nM
COc1ccc(-n2nc(C(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]nc(C(=O)N(C)C)c5c4)n3)c3ccccc23)cc1 CHEMBL3922538 IC50 908.0 nM
N#Cc1ncc2nc1OCCCCOc1cc(NCc3cncs3)c(Cl)cc1NC(=O)N2 CHEMBL248757 Ki 911.0 nM
Nc1nc(Nc2cccc(F)c2)nc(NCCO)c1[N+](=O)[O-] CHEMBL1405580 AC50 953.0 nM
O/N=C/c1cn(-c2ccccc2)nc1-c1ccc2c(c1)OCCO2 CHEMBL1896042 AC50 984.0 nM
CCCCOC(=O)C1C(C)=Nc2ncnn2C1c1cccc(OC)c1OC CHEMBL1905464 AC50 989.0 nM
O=c1[nH]c2ncc(-c3ccc4[nH]cnc4c3)nc2n1CC1CCCCC1 CHEMBL1946262 IC50 990.0 nM