CN1C(=O)COc2ccc(-c3nn(Cc4ccccc4)c(=O)c4ccccc34)cc21 CHEMBL5418358 IC50 -10.6 nM
COc1ccc(OCC(=O)Nc2cccc(-c3nc4ccccc4c(=O)o3)c2)cc1 CHEMBL5417193 IC50 -10.6 nM
O=C(C1=C(O)C(=O)N(CCc2c[nH]c3ccccc23)C1c1cccnc1)c1ccc(Cl)cc1 CHEMBL5408917 IC50 -10.4 nM
NC(=O)CN1C(=O)C(O)(CC(=O)c2ccc3ccccc3c2)c2ccccc21 CHEMBL5430630 IC50 -10.3 nM
CN1CCN(S(=O)(=O)c2ccc(-c3cnc(N)c(C(=O)Nc4cccnc4)n3)cc2)CC1 CHEMBL2177161 IC50 0.004 nM
O=C1NC(=O)C(c2cn3c4c(cc(F)cc24)CN(C(=O)N2CCOCC2)CC3)=C1c1coc2ccccc12 CHEMBL2386094 IC50 0.013 nM
CC(C)Oc1ccc(F)c(-c2cnc(N)c(C(=O)Nc3cnccc3N3CCC[C@@H](C(=O)O)C3)n2)c1 CHEMBL4647659 Kd 0.046 nM
Cn1cc(C2=C(c3cccc(NC[C@H](O)CO)c3)C(=O)NC2=O)c2cc(F)ccc21 CHEMBL1232189 Kd 0.05 nM
Cn1cc(C2=C(c3cccc(NCC(O)CO)c3)C(=O)NC2=O)c2cc(F)ccc21 CHEMBL1082152 Kd 0.053 nM
C[C@H]1COCCN1c1ccncc1NC(=O)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5290966 IC50 0.06 nM
Nc1nc(NCCNc2ncc(-c3ncc[nH]3)c(-c3ccc(Cl)cc3Cl)n2)ccc1[N+](=O)[O-] CHEMBL1080901 IC50 0.06 nM
N#Cc1ccc(Nc2nccc(C(=O)Nc3cnccc3OCC(F)(F)F)n2)cc1 CHEMBL5409061 IC50 0.07 nM
O=[N+]([O-])c1ccc(NCCNc2ncc(-c3ncc[nH]3)c(-c3ccc(Cl)cc3Cl)n2)nc1 CHEMBL461262 Ki 0.09 nM
Nc1ncc(-c2ccccc2F)nc1C(=O)Nc1cnccc1N1CCC(N)CC1 CHEMBL3895998 IC50 0.1 nM
COc1ccc(N2CCN(c3nc(-c4ccncn4)cc(=O)n3C)[C@H](C)C2)cc1 CHEMBL4084855 IC50 0.1 nM
CC(C)(O)c1ccncc1NC(=O)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5268011 IC50 0.1 nM
COc1cc(C2=C(c3cn(CCN4CCN(C)CC4)c4ccccc34)C(=O)NC2=O)c2occc2c1 CHEMBL564450 IC50 0.14 nM
CC1(C)COCCN1c1ccncc1NC(=O)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5278104 IC50 0.15 nM
N#Cc1ccc(Nc2nccc(C(=O)Nc3cnccc3-c3ccccc3)n2)cc1 CHEMBL5404581 IC50 0.15 nM
O=C(Nc1cnccc1N1CCC(F)(F)CC1)c1ccnc(NC(=O)[C@H]2C[C@@H](Cl)C2)c1 CHEMBL5284020 IC50 0.16 nM
COc1ccc(Nc2nccc(C(=O)Nc3cnccc3-c3ccccc3)n2)cc1F CHEMBL5418606 IC50 0.18 nM
O=C(Nc1cnccc1N1CCC(F)(F)CC1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5282887 IC50 0.19 nM
O=C1NC(=O)C(c2cn3c4c(cccc24)CN(C(=O)c2cnccn2)CC3)=C1c1coc2ccccc12 CHEMBL2386090 IC50 0.2 nM
Nc1ncc(-c2ccccc2)nc1C(=O)Nc1cnccc1N1CCC(N)CC1 CHEMBL3963605 IC50 0.2 nM
COc1ccc(-c2cnc(N)c(C(=O)Nc3cnccc3N3CCC(N)CC3)n2)cc1 CHEMBL3942619 IC50 0.2 nM
Nc1ncc(-c2ccccc2F)nc1C(=O)Nc1cnccc1N1CCNCC1 CHEMBL3957649 IC50 0.2 nM
C[C@@H]1CN(c2ccccc2F)CCN1c1nc(-c2ccncn2)cc(=O)n1C CHEMBL4077376 IC50 0.2 nM
COc1cccc(N2CCN(c3nc(-c4ccncn4)cc(=O)n3C)[C@H](C)C2)c1 CHEMBL4063206 IC50 0.2 nM
CC1CN(c2ccncc2NC(=O)c2ccnn3cc(-c4ccccc4)nc23)CCO1 CHEMBL5270781 IC50 0.2 nM
O=C(Nc1cnccc1N1CCC(F)(F)CC1)c1ccnc(Nc2ccccc2)n1 CHEMBL5437994 IC50 0.2 nM
O=C(Nc1cnccc1OCC(F)(F)F)c1ccnc(Nc2ccccc2)n1 CHEMBL5416472 IC50 0.2 nM
CN1CCN(S(=O)(=O)c2ccc(-c3cnc(N)c(C(=O)Nc4cnccc4CN4CCCC4)n3)cc2)CC1 CHEMBL2177173 Ki 0.22 nM
COCc1cccc2c(C3=C(c4coc5ccccc45)C(=O)NC3=O)cn(C)c12 CHEMBL491647 IC50 0.23 nM
COc1cccc(OC)c1[C@H]1CN(c2nc(-c3ccncn3)cc(=O)n2C)CCO1 CHEMBL3091542 IC50 0.23 nM
N#Cc1ccc(Nc2nccc(C(=O)Nc3cnccc3-c3ccccc3)n2)cc1Cl CHEMBL5440672 IC50 0.24 nM
COc1cc(F)ccc1C1CN(c2nc(-c3ccncn3)cc(=O)n2C)CCN1 CHEMBL4076186 IC50 0.25 nM
CC(O)c1ccncc1NC(=O)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5283410 IC50 0.25 nM
O=C(Nc1cnccc1-c1ccc(F)cc1)c1ccnc(Nc2ccccc2)n1 CHEMBL5414726 IC50 0.25 nM
CS(=O)(=O)c1ccc(Nc2nccc(C(=O)Nc3cnccc3-c3ccccc3)n2)cc1 CHEMBL5407971 IC50 0.25 nM
COc1ccc(-c2ocnc2C(=O)NCCCc2ccc(NC(=O)/C=C/c3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)cc2)cc1Cl CHEMBL5421040 IC50 0.25 nM
COc1ccc(-c2ocnc2C(=O)NCCCn2cc(CNC(=O)CCc3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)nn2)cc1Cl CHEMBL5419215 IC50 0.27 nM
O=C(Nc1cnccc1OCC(F)(F)F)c1ccnc(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL5422776 IC50 0.28 nM
NC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCC1CC1 CHEMBL3410091 IC50 0.29 nM
O=C1NC(=O)C(c2cnc3cccnn23)=C1c1cn2c3c(cccc13)CN(C(=O)N1CCCCC1)CC2 CHEMBL181031 IC50 0.3 nM
Cc1ccc(Nc2nccc(C(=O)Nc3cnccc3-c3ccccc3)n2)cc1 CHEMBL5436595 IC50 0.31 nM
COc1ccc(-c2ocnc2C(=O)NCCCn2cc(CNC(=O)c3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)nn2)cc1I CHEMBL5410665 IC50 0.31 nM
COc1ccc(-c2ocnc2C(=O)NCCCn2cc(CNC(=O)/C=C/c3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)nn2)cc1I CHEMBL5434153 IC50 0.33 nM
Cn1cc(C2=C(c3coc4cc(CO)ccc34)C(=O)NC2=O)c2cc(F)ccc21 CHEMBL477038 IC50 0.35 nM
N#Cc1ccc(Nc2nccc(C(=O)Nc3cnccc3-c3ccc(F)cc3)n2)cc1 CHEMBL5419652 IC50 0.35 nM
NC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OC1CCC1 CHEMBL3410092 IC50 0.37 nM
O=C(Nc1cnccc1N1CCC(F)(F)CC1)c1ccnc(NC(=O)[C@H]2C[C@H](Cl)C2)c1 CHEMBL5291181 IC50 0.37 nM
COc1ccc(C2=NNC(=O)/C2=N\Nc2cccc(Cl)c2)cc1OC CHEMBL1088011 Ki 0.4 nM
COc1cccc(N/N=C2\C(=O)NN=C2c2ccc(OC)c(OC)c2)c1 CHEMBL1088145 Ki 0.4 nM
Cn1cc(C2=C(c3cccc(NCC(O)CO)c3)C(=O)NC2=O)c2cc(Cl)ccc21 CHEMBL1082153 IC50 0.4 nM
Nc1ncc(-c2ccc(S(=O)(=O)N3CCCCC3)cc2)nc1C(=O)Nc1cccnc1 CHEMBL2177163 Ki 0.4 nM
C[C@@H]1CN(c2ccc(F)cc2)CCN1c1nc(-c2ccncn2)cc(=O)n1C CHEMBL4076060 IC50 0.4 nM
COc1cc(F)ccc1C1CN(c2nc(-c3ccncc3)cc(=O)n2C)CCN1 CHEMBL4087402 IC50 0.4 nM
Cn1cc(C2=C(c3coc4ccccc34)C(=O)NC2=O)c2cc(F)ccc21 CHEMBL5175996 IC50 0.4 nM
COc1ccc(-c2ocnc2C(=O)NCCCNC(=O)/C=C/c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cc1Cl CHEMBL5407410 IC50 0.41 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(Nc2ccccc2)n1 CHEMBL5424348 IC50 0.43 nM
Cc1cc(C#N)ccc1Nc1nccc(C(=O)Nc2cnccc2-c2ccccc2)n1 CHEMBL5404070 IC50 0.43 nM
CC(C)Oc1nc(-c2ccnc(NC(=O)C3CC3)c2)sc1C(N)=O CHEMBL3410090 IC50 0.45 nM
COc1ccc(Nc2nccc(C(=O)Nc3cnccc3-c3ccccc3)n2)cc1 CHEMBL5438689 IC50 0.45 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(Nc2ccc(OC(F)F)cc2)n1 CHEMBL5435368 IC50 0.45 nM
O=C(Nc1cnccc1-c1ccc(F)cc1)c1ccnc(Nc2ccc(OC(F)F)cc2)n1 CHEMBL5422112 IC50 0.45 nM
Cc1cc(S(=O)(=O)N2CCN(C)CC2)ccc1-c1cnc(N)c(C(=O)Nc2cccnc2)n1 CHEMBL2182002 Ki 0.46 nM
O=C(Nc1cnccc1-c1ccc(Cl)cc1)c1ccnc(NC(=O)C2CCC(F)(F)C2)c1 CHEMBL5286043 IC50 0.46 nM
COc1cc(F)ccc1[C@H]1CN(c2nc(-c3ccncn3)cc(=O)n2C)CCO1 CHEMBL3091541 IC50 0.47 nM
CN(C)Cc1ccncc1NC(=O)c1nc(-c2ccc(S(=O)(=O)N3CCCC3)cc2)cnc1N CHEMBL2177174 Ki 0.48 nM
COc1ccc(-c2ocnc2C(=O)NCCCNC(=O)c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cc1I CHEMBL5394929 IC50 0.48 nM
C[C@@H]1COCCN1c1ccncc1NC(=O)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5282113 IC50 0.49 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(Nc2ccc(Cl)cc2)n1 CHEMBL5414551 IC50 0.49 nM
C[C@@H]1CN(c2cccc(F)c2)CCN1c1nc(-c2ccncn2)cc(=O)n1C CHEMBL4095848 IC50 0.5 nM
COc1ccc(-c2c[nH]c3ncc(/C=C/C(=O)NCc4ccncc4)cc23)cc1 CHEMBL4468662 IC50 0.508 nM
Cn1cc(C2=C(c3coc4cc(CO)ccc34)C(=O)NC2=O)c2cc(Br)ccc21 CHEMBL489833 IC50 0.51 nM
O=C1NC(=O)C(c2cn3c4c(cc(F)cc24)CN(C(=O)N2CCC(N4CCCCC4)CC2)CC3)=C1c1coc2ccccc12 CHEMBL2386093 IC50 0.53 nM
O=C(Nc1cnccc1-c1ccc(F)cc1)c1ccnc(Nc2ccc(F)cc2)n1 CHEMBL5402829 IC50 0.56 nM
C[C@H]1COc2c(NCCNc3ccccn3)c(F)c(N)c3c(=O)c(C#N)cn1c23 CHEMBL1940976 IC50 0.57 nM
O=C1NC(=O)C(c2cn3c4c(cccc24)CN(C(=O)Cc2ccncc2)CC3)=C1c1coc2ccccc12 CHEMBL2386091 IC50 0.59 nM
C[C@H]1COc2c(NCCCc3ccccn3)c(F)c(N)c3c(=O)c(C#N)cn1c23 CHEMBL1940990 IC50 0.6 nM
Nc1nc(NCCNc2ncc(-n3ccnc3)c(-c3ccc(Cl)cc3Cl)n2)ccc1[N+](=O)[O-] CHEMBL3185148 IC50 0.6 nM
CCOc1ccncc1NC(=O)c1ccnc(NC(=O)C2CCCC2)c1 CHEMBL5276076 IC50 0.62 nM
COc1ccc(-c2ocnc2C(=O)NCCCCNC(=O)c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cc1F CHEMBL5417641 IC50 0.62 nM
Cn1c(N2CCO[C@@H](c3c(F)cccc3Cl)C2)nc(-c2ccncn2)cc1=O CHEMBL3091544 IC50 0.64 nM
Nc1ncc(-c2ccc(S(=O)(=O)N3CCOCC3)cc2)nc1C(=O)Nc1cccnc1 CHEMBL2177165 Ki 0.67 nM
O=C1NC(=O)C(c2cnc3ccccn23)=C1c1cn2c3c(cc(F)cc13)CN(C(=O)N1CCCCC1)CC2 CHEMBL362558 IC50 0.7 nM
CCCC1=C(c2nnc(C)o2)C(c2cccc(C#N)c2Br)c2c[nH]nc2N1 CHEMBL270265 IC50 0.7 nM
CC(C)C(=O)Nc1cc(C(=O)Nc2cnccc2OCC(F)(F)F)ccn1 CHEMBL5271077 IC50 0.72 nM
COCc1cccc2c(C3=C(c4coc5cc(CO)ccc45)C(=O)NC3=O)cn(C)c12 CHEMBL490636 IC50 0.73 nM
O=C1NC(=O)C(c2cn(CCC3N=CC=N3)c3ccccc23)=C1c1noc2ccccc12 CHEMBL4084151 IC50 0.73 nM
CCCn1cnc(C2C=C(C3=C(c4noc5ccccc45)C(=O)NC3=O)c3ccccc32)c1 CHEMBL4802108 IC50 0.73 nM
N#Cc1ccc(Nc2nccc(C(=O)Nc3cncnc3OCC(F)(F)F)n2)cc1 CHEMBL5428013 IC50 0.74 nM
COc1ccc(-c2ocnc2C(=O)NCCCn2cc(CNC(=O)/C=C/c3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)nn2)cc1Cl CHEMBL5399975 IC50 0.76 nM
COc1ccc(CC(=O)Nc2cc([C@H]3CC[C@@H](OC(=O)N4C[C@@H](C#N)[C@@H]4C)C3)[nH]n2)cn1 CHEMBL4758595 Ki 0.78 nM
COc1ccc(-c2ocnc2C(=O)NCCCCNC(=O)CCc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cc1F CHEMBL5409743 IC50 0.78 nM
CC1(C)CN(c2ccncc2NC(=O)c2ccnc(NC(=O)C3CC3)c2)CCO1 CHEMBL5272041 IC50 0.79 nM
O=C1NC(=O)C(c2cncc3ccoc23)=C1c1cn2c3c(cccc13)CN(C(=O)N1CCOCC1)CC2 CHEMBL178766 pIC50 0.7943 nM
N#CCCc1ccc2c(c1)-c1[nH]c3ccc([N+](=O)[O-])cc3c1CC(=O)N2 CHEMBL260138 IC50 0.8 nM
O=C(Nc1n[nH]c2nc(-c3ccc(O)cc3)c(Br)cc12)C1CC1 CHEMBL260417 IC50 0.8 nM
COc1ccc(C2=NNC(=O)/C2=N\Nc2cccc(OC)c2)cc1 CHEMBL1080902 Ki 0.8 nM
COc1ccccc1N1CCN(c2nc(-c3ccncn3)cc(=O)n2C)[C@H](C)C1 CHEMBL4065818 IC50 0.8 nM
CC(C)c1c2cc(-c3ccnc(Nc4ccc5c(N6CCN(C)CC6)ccnc5c4)n3)ccc2nn1C CHEMBL4856177 IC50 0.8 nM
COc1ccc(-c2ocnc2C(=O)NCCCCNC(=O)c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cc1Cl CHEMBL5424793 IC50 0.81 nM
COc1ccc(-c2ocnc2C(=O)NCCCn2cc(CNC(=O)CCc3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)nn2)cc1I CHEMBL5402499 IC50 0.81 nM
CC(C)Oc1nc(-c2ccnc(NC(=O)C3CC3)c2)ncc1C(N)=O CHEMBL3410111 IC50 0.83 nM
COc1ccc(-c2ocnc2C(=O)NCCCCNC(=O)CCc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cc1Cl CHEMBL5422975 IC50 0.84 nM
CC(=O)c1ccncc1NC(=O)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5290181 IC50 0.85 nM
C[C@H]1COc2c(NCCCn3cccn3)c(F)c(N)c3c(=O)c(C#N)cn1c23 CHEMBL1940981 IC50 0.86 nM
Cn1cc(C2=C(c3cnc4ccccn34)C(=O)NC2=O)c2cc(Br)ccc21 CHEMBL2386272 IC50 0.87 nM
COc1ccccc1[C@H]1CN(c2nc(-c3ccncn3)cc(=O)n2C)CCO1 CHEMBL3091540 IC50 0.87 nM
O=C(Nc1cnccc1-c1ccc(F)cc1C(F)(F)F)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5268185 IC50 0.87 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(Nc2ccc(C(F)(F)F)cn2)c1 CHEMBL5413819 IC50 0.89 nM
O=C1NC(=O)C(c2cn3c4c(cc(F)cc24)CN(C(=O)N2CCCCC2)CC3)=C1c1cn2ccccc2n1 CHEMBL5178166 IC50 0.9 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(Nc2ccc(Cl)cn2)c1 CHEMBL5415012 IC50 0.9 nM
COc1ccc(-c2ocnc2C(=O)NCCCc2ccc(NC(=O)c3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)cc2)cc1Cl CHEMBL5409378 IC50 0.92 nM
Cn1cc(C2=C(c3coc4cc(CO)ccc34)C(=O)NC2=O)c2cc(F)c(Cl)cc21 CHEMBL522590 IC50 0.95 nM
COc1ccc(CC(=O)Nc2cc([C@@H]3CC[C@H](OC(=O)N4CCC4(C)C)C3)[nH]n2)cn1 CHEMBL4764153 Ki 0.95 nM
O=C(Nc1cnccc1C(=O)C(F)(F)F)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5273034 IC50 0.95 nM
COc1c(F)cc(-c2ocnc2C(=O)NCCCc2ccc(NC(=O)/C=C/c3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)cc2)cc1F CHEMBL5438491 IC50 0.95 nM
COc1c(F)cc(-c2ocnc2C(=O)NCCCNC(=O)c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cc1F CHEMBL5394559 IC50 0.96 nM
CN1CCN(S(=O)(=O)c2ccc(-c3cnc(N)c(C(=O)Nc4ncns4)n3)cc2)CC1 CHEMBL2177177 Ki 0.99 nM
O=C(Nc1cnccc1N1CCCCC1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5288950 IC50 0.99 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccnc(NC(=O)C3CC3)c2)CCO1 CHEMBL5281590 IC50 0.99 nM
CN1CCC(C(=O)Nc2n[nH]c3nc(-c4ccc(O)cc4)c(Br)cc23)CC1 CHEMBL261129 IC50 1.0 nM
O=C(Nc1n[nH]c2nc(-c3ccc(O)cc3)c(Cl)cc12)C1CC1 CHEMBL260664 IC50 1.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 IC50 1.0 nM
Cn1cc(C2=C(c3cccc(NCCCO)c3)C(=O)NC2=O)c2ccccc21 CHEMBL1082151 IC50 1.0 nM
C[C@H]1COc2c(NCCCn3ccnc3)c(F)c(N)c3c(=O)c(C#N)cn1c23 CHEMBL1940986 IC50 1.0 nM
CS(=O)(=O)Nc1ccc(CCNC(=O)c2ccc(O)c3[nH]c(-c4ccc(F)cc4)nc23)cc1 CHEMBL1957949 IC50 1.0 nM
CCS(=O)(=O)Nc1ccc(CCNC(=O)c2ccnc3[nH]c(-c4ccoc4)nc23)cc1 CHEMBL2048663 IC50 1.0 nM
Nc1ncc(-c2ccccc2)nc1C(=O)Nc1ccccc1N1CCC(N)CC1 CHEMBL3943813 IC50 1.0 nM
Cc1cc(C)cc(Nc2nccc(-c3cnn4ncccc34)n2)c1 CHEMBL186101 pIC50 1.0 nM
c1cnn2ncc(-c3ccnc(Nc4ccc5c(c4)OCCO5)n3)c2c1 CHEMBL361894 pIC50 1.0 nM
O=C(Nc1cnccc1N1CCOCC1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5289779 IC50 1.0 nM
O=C(Nc1cncc(C2CCC2)c1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5273531 IC50 1.0 nM
CC(C)(C)COc1ccncc1NC(=O)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5270885 IC50 1.0 nM
CN1CCN(S(=O)(=O)c2ccc(-c3cnc(N)c(C(=O)Nc4cccnc4)n3)c(C(F)(F)F)c2)CC1 CHEMBL2177155 Ki 1.1 nM
COc1nc(-c2ccnc(NC(=O)C3CC3)c2)sc1C(N)=O CHEMBL3410089 IC50 1.1 nM
Cn1c(N2CCNC(c3cccc(Cl)c3)C2)nc(-c2ccncn2)cc1=O CHEMBL4067532 IC50 1.1 nM
O=CN1Cc2cc(F)cc3c(C4=C(c5cnc6ccccn56)C(=O)NC4=O)cn(c23)CC1N1CCCCC1 CHEMBL4165510 IC50 1.1 nM
O=C(Nc1cncnc1OCC(F)(F)F)c1ccnc(Nc2ccccc2)n1 CHEMBL5417065 IC50 1.1 nM
O=C(Nc1cnccc1-c1ccc(F)cc1)c1ccnc(Nc2ccc(Cl)cc2)n1 CHEMBL5432510 IC50 1.1 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(Nc2ccncc2)n1 CHEMBL5401931 IC50 1.1 nM
Cn1cc(C2=C(c3coc4ccccc34)C(=O)NC2=O)c2cccc(CCC(=O)O)c21 CHEMBL490842 IC50 1.2 nM
C[C@@H]1CN(c2ccc(Cl)cc2)CCN1c1nc(-c2ccncn2)cc(=O)n1C CHEMBL4077048 IC50 1.2 nM
Cn1c(N2CCN[C@@H](c3ccc(Cl)cc3)C2)nc(-c2ccncn2)cc1=O CHEMBL4105346 IC50 1.2 nM
O=C(Nc1cncc(-c2ccccc2)c1)c1ccnc(NC(=O)C2CCCC2)c1 CHEMBL5286581 IC50 1.2 nM
N#CCc1ccc(Nc2nccc(Nc3cc(C4CC4)[nH]n3)n2)cc1 CHEMBL1235645 IC50 1.2 nM
O=C(Nc1cnccc1-c1ccc(F)cc1Cl)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5290300 IC50 1.2 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(Nc2cccnc2)n1 CHEMBL5410129 IC50 1.2 nM
COc1ccc(CC(=O)Nc2cc([C@H]3CC[C@@H](OC(=O)N4CCC4(C)C)C3)[nH]n2)cn1 CHEMBL4744945 Ki 1.26 nM
CC(C)OC(=O)N1CCn2cc(C3=C(c4cnc5ccccn45)C(=O)NC3=O)c3cccc(c32)C1 CHEMBL363058 IC50 1.3 nM
O=C1NC(=O)C(c2cnc3ccccn23)=C1c1cn2c3c(cccc13)CN(C(=O)N1CCOCC1)CC2 CHEMBL178737 IC50 1.3 nM
CN1CCN(S(=O)(=O)c2ccc(-c3cnc(N)c(C(=O)Nc4cccnc4)n3)c(F)c2)CC1 CHEMBL2182001 Ki 1.3 nM
O=CN1Cc2cccc3c(C4=C(c5cnc6ccccn56)C(=O)NC4=O)cn(c23)CC1N1CCOCC1 CHEMBL4162850 IC50 1.3 nM
CC(C)OC1Cn2cc(C3=C(c4cnc5ccccn45)C(=O)NC3=O)c3cccc(c32)CN1C=O CHEMBL4164416 IC50 1.3 nM
CC(=O)c1ccc(-c2c[nH]c3ncc(/C=C/C(=O)NCCc4ccccn4)cc23)cc1 CHEMBL4521500 IC50 1.37 nM
C[C@H]1COc2c(NCCCc3ccccc3)c(F)c(N)c3c(=O)c(C#N)cn1c23 CHEMBL1940979 IC50 1.4 nM
C[C@@H]1CN(c2ccccc2)CCN1c1nc(-c2ccncn2)cc(=O)n1C CHEMBL3719193 IC50 1.4 nM
CC(C)C(=O)Nc1cc(C(=O)Nc2cnccc2-c2ccccc2)ccn1 CHEMBL5289493 IC50 1.4 nM
CC(C)C(=O)Nc1cc(C(=O)Nc2cnccc2OCC(C)(F)F)ccn1 CHEMBL5272115 IC50 1.4 nM
O=C(Nc1cncc(-c2ccccc2F)c1)c1ccnc(NC(=O)C2CCC(F)(F)C2)c1 CHEMBL5271607 IC50 1.4 nM
CCC(CO)CNC(=O)O[C@@H]1CC[C@H](c2cc(NC(=O)Cc3ccc(OC)nc3)n[nH]2)C1 CHEMBL4763408 Ki 1.41 nM
CC(=O)c1ccc(-c2c[nH]c3ncc(/C=C/C(=O)NCc4ccncc4)cc23)cc1 CHEMBL4579826 IC50 1.42 nM
COc1cnc(-c2cnc3ccccc3c2)nc1-c1cc2c([nH]1)CCNC2=O CHEMBL2203552 IC50 1.491 nM
Cc1cc(-c2cc(-c3nc4ccc(CN5CCN(C)CC5)cc4[nH]3)c(=O)[nH]n2)cc(C)c1O CHEMBL270473 IC50 1.5 nM
CCOc1ccncc1NC(=O)c1ccnc2[nH]c(-c3ccc(F)cc3)nc12 CHEMBL2048678 EC50 1.5 nM
Cc1cc(S(=O)(=O)N2CCN(C)CC2)c(C)cc1-c1cnc(N)c(C(=O)Nc2cccnc2)n1 CHEMBL2177156 Ki 1.5 nM
CN(C)CCNC(=O)c1ccc(/C=N/Nc2ncnc3c2cnn3-c2cccc3[nH]cnc23)cc1 CHEMBL304533 pIC50 1.585 nM
O=C1NC(=O)C(c2cnc3ccccn23)=C1c1cn2c3c(cccc13)CN(C(=O)N1CCCCC1)CC2 CHEMBL362588 IC50 1.6 nM
CN(C)C(=O)N1CCn2cc(C3=C(c4cnc5ccccn45)C(=O)NC3=O)c3cccc(c32)C1 CHEMBL362814 IC50 1.6 nM
CN(C)C1Cn2cc(C3=C(c4cnc5ccccn45)C(=O)NC3=O)c3cccc(c32)CN1C=O CHEMBL4169204 IC50 1.6 nM
Cn1c(N2CCNC(c3ccc(Cl)cc3)C2)nc(-c2ccncn2)cc1=O CHEMBL4104714 IC50 1.7 nM
COc1cc(F)cc(F)c1C1CN(c2nc(-c3ccncn3)cc(=O)n2C)CCN1 CHEMBL4071429 IC50 1.7 nM
CC1(C)CC(C(=O)Nc2cc(C(=O)Nc3cnccc3-c3ccccc3)ccn2)C1 CHEMBL5272651 IC50 1.7 nM
O=C(Nc1cnccc1-c1ccc(Cl)cc1)c1ccnc(NC(=O)[C@H]2C[C@H](F)C2)c1 CHEMBL5290846 IC50 1.7 nM
Cc1ncc(CC(=O)Nc2cc([C@H]3CC[C@@H](OC(=O)N4C[C@@H](C#N)[C@@H]4C)C3)[nH]n2)s1 CHEMBL4758192 Ki 1.72 nM
Cn1cc(C2=C(c3cccc(CC(O)CO)c3)C(=O)NC2=O)c2cc(F)ccc21 CHEMBL1081973 IC50 1.8 nM
Cn1cc(C2=C(c3cccc(N)c3)C(=O)NC2=O)c2ccccc21 CHEMBL54547 IC50 1.8 nM
COc1ccccc1C1CN(c2nc(-c3ccncc3)cc(=O)n2C)CCN1 CHEMBL4085821 IC50 1.8 nM
COc1ccccc1C1CN(c2nc(-c3ccncn3)cc(=O)n2C)CCN1 CHEMBL4065624 IC50 1.8 nM
CC(C)C(=O)Nc1cc(C(=O)Nc2cnccc2OCC(F)F)ccn1 CHEMBL5266570 IC50 1.8 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(Nc2ccc(OC(F)(F)F)cc2)n1 CHEMBL5433893 IC50 1.8 nM
COc1ccc(CC(=O)Nc2cc([C@@H]3CC[C@H](OC(=O)N[C@H]4CC[C@H](O)CC4)C3)[nH]n2)cn1 CHEMBL4744114 Ki 1.85 nM
COc1ccc(C2=NNC(=O)/C2=N\Nc2cccc(Cl)c2)cc1 CHEMBL1076701 Ki 1.9 nM
O=C1NC(=O)C(c2cn3c4c(cc(F)cc24)CN(C(=O)N2CCCCC2)CC3)=C1c1coc2ccccc12 CHEMBL2386092 IC50 1.9 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(NC(=O)C2CC(F)(F)C2)c1 CHEMBL5282635 IC50 1.9 nM
CC(C)Oc1ccncc1NC(=O)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5283654 IC50 1.9 nM
O=C(Nc1cnccc1-c1ccc(F)cc1F)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5273872 IC50 1.9 nM
c1ccc(CNc2nc(Nc3cc(C4CC4)[nH]n3)c3sccc3n2)cc1 CHEMBL1997924 Kd 1.952 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cc(F)ccc1F CHEMBL1995811 pKi 1.995 nM
C#Cc1ccc2c(c1)[nH]c1ncnc(N3CCC4CCN(CCC#N)CC43)c12 CHEMBL5077814 pIC50 1.995 nM
N=C1NC(=O)/C(=C/c2ccc(-c3ccc(S(N)(=O)=O)c(C(F)(F)F)c3)o2)S1 CHEMBL233970 IC50 2.0 nM
O=[N+]([O-])c1cccc(Nc2nccc(-c3cnn4ncccc34)n2)c1 CHEMBL526110 IC50 2.0 nM
CCS(=O)(=O)Nc1ccc(CCNC(=O)c2ccc(O)c3[nH]c(-c4ccc(F)cc4Cl)nc23)cc1 CHEMBL549953 IC50 2.0 nM
COc1ccc(N/N=C2\C(=O)NN=C2c2ccc(OC)cc2)cc1 CHEMBL1081633 Ki 2.0 nM
COc1ccc(N/N=C2\C(=O)NN=C2c2cnccc2OC)cc1 CHEMBL1079966 Ki 2.0 nM
COc1ccc(C2=NNC(=O)/C2=N\Nc2ccc(Cl)cc2)cc1 CHEMBL1080849 Ki 2.0 nM
COc1ccc(C2=NNC(=O)/C2=N\Nc2cccnc2)cc1 CHEMBL1076721 Ki 2.0 nM
CCN(CC)c1ccc(N/N=C2\C(=O)NN=C2c2ccc(OC)c(OC)c2)cc1 CHEMBL1086602 Ki 2.0 nM
CCS(=O)(=O)Nc1ccc(CCNC(=O)c2ccnc3[nH]c(-c4ccc(F)cc4F)nc23)cc1 CHEMBL2048660 IC50 2.0 nM
COc1ccc(-c2nc3c(C(=O)Nc4cnccc4C)ccnc3[nH]2)cc1 CHEMBL2048680 IC50 2.0 nM
COc1ccncc1NC(=O)c1ccnc2[nH]c(-c3cccc(Cl)c3)nc12 CHEMBL2048684 IC50 2.0 nM
COc1ccncc1NC(=O)c1ccnc2[nH]c(-c3ccncc3)nc12 CHEMBL2048685 IC50 2.0 nM
COCCNS(=O)(=O)c1ccc(-c2cnc(N)c(C(=O)Nc3cccnc3)n2)cc1 CHEMBL2177159 Ki 2.0 nM
CCN(Cc1cn2ccccc2n1)Cc1nc2ccccc2c(=O)[nH]1 CHEMBL2297160 IC 2.0 nM
COc1ccc2c(c1)[n-]c1c3ccccc3[s+]cc21 CHEMBL2297159 IC 2.0 nM
Cc1cc2[n-]c3c4ccccc4[s+]cc3c2cc1C CHEMBL2297172 IC 2.0 nM
COc1cc(C2=C(c3cn(CCCO)c4ccccc34)C(=O)NC2=O)cc(OC)c1OC CHEMBL3699446 IC50 2.0 nM
Cn1c(N2CCNC(c3cccc(Br)c3)C2)nc(-c2ccncn2)cc1=O CHEMBL4088777 IC50 2.0 nM
COc1cc(F)cc(F)c1C1CN(c2nc(-c3ccncc3)cc(=O)n2C)CCN1 CHEMBL4098458 IC50 2.0 nM
O=CN1Cc2cccc3c(C4=C(c5cnc6ccccn56)C(=O)NC4=O)cn(c23)CC1N1CCCCC1 CHEMBL4172295 IC50 2.0 nM
Cc1cc(Nc2cc(Cl)nc(Oc3ccc([N+](=O)[O-])cc3)n2)n[nH]1 CHEMBL4639853 IC50 2.0 nM
CC(C)OCCCC(=O)c1n[nH]cc1NC(=O)c1ccccc1 CHEMBL5291119 IC50 2.0 nM
O=C(Nc1cnccc1-c1ccccc1C(F)(F)F)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5265990 IC50 2.0 nM
Cc1ccc(C(=O)Nc2c[nH]nc2C(=O)NCCCOC(C)C)cn1 CHEMBL5284549 IC50 2.0 nM
Cc1ccc(C(=O)Nc2c[nH]nc2C(=O)CCCOC(C)C)cn1 CHEMBL5429353 IC50 2.0 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL5420646 IC50 2.0 nM
COc1ccc(CNC(=O)Nc2ncc([N+](=O)[O-])s2)cc1 CHEMBL259850 IC50 2.07 nM
COc1ccc(/C=C2\S/C(=N\Cc3ccccc3)NC2=O)cc1[N+](=O)[O-] CHEMBL3949218 IC50 2.1 nM
COc1ccc(-c2ocnc2C(=O)NCCCn2cncn2)cc1Cl CHEMBL5173945 IC50 2.1 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(NC(=O)C2CCCC2)c1 CHEMBL5280118 IC50 2.1 nM
COc1ccc(-c2ccncc2NC(=O)c2ccnc(NC(=O)C3CC3)c2)cc1 CHEMBL5269649 IC50 2.1 nM
O=C(Nc1cnccc1-c1ccc(F)cc1)c1ccnc(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL5431425 IC50 2.1 nM
C[C@@H]1CN(c2cccc(C#N)c2)CCN1c1nc(-c2ccncn2)cc(=O)n1C CHEMBL4074586 IC50 2.2 nM
CCOc1ccncc1NC(=O)c1ccnc(NC(=O)C2CCC2)c1 CHEMBL5276749 IC50 2.2 nM
O=C(Nc1cnccc1-c1ccc(Cl)cc1Cl)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5280368 IC50 2.2 nM
Cc1n[nH]c2ccc(-c3nnc4n3[C@H](c3ccc(Cl)cc3)CC4)cc12 CHEMBL5434183 Kd 2.2 nM
COc1ccc(-n2cnc3ccc(-c4nnc(SCc5cccc(C#N)c5)o4)cc32)cc1 CHEMBL516640 IC50 2.3 nM
Cn1c(N2CCNC(c3ccc(Cl)c(Cl)c3)C2)nc(-c2ccncn2)cc1=O CHEMBL4072455 IC50 2.3 nM
COc1ccc(-n2cnc3ccc(-c4n[nH]c(=S)o4)cc32)cc1 CHEMBL1230134 IC50 2.3 nM
CC(C)C(=O)Nc1cc(C(=O)Nc2cnccc2OCCN2CCOCC2)ccn1 CHEMBL5287772 IC50 2.3 nM
COc1ccc(C2=C(c3cn(C)c4ccccc34)C(=O)NC2=O)c(OC)c1 CHEMBL1088149 IC50 2.4 nM
C[C@H]1COc2c(NCCCc3ccccn3)c(F)c(N)c3c(=O)c(-c4nnn[nH]4)cn1c23 CHEMBL1940989 IC50 2.4 nM
O=C1NCCCc2cc(-c3ccnc(NC(=O)C4CC4)c3)ccc21 CHEMBL3410096 IC50 2.4 nM
O=C1NCCc2cc(-c3ccnc(NC(=O)C4CC4)c3)ccc21 CHEMBL3410094 IC50 2.4 nM
O=C(Nc1cnccc1OCC1CC1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5271618 IC50 2.4 nM
CN1CCC(C2=C(C#N)[C@H](c3cccc4nonc34)c3c[nH]nc3N2)CC1 CHEMBL3085387 IC50 2.5 nM
COc1ccc(-n2cnc3ccc(-c4nnc(SCc5cccc(C(F)(F)F)c5)o4)cc32)cc1 CHEMBL513570 IC50 2.5 nM
Cc1ccc(-c2cncc(NC(=O)c3ccnc(NC(=O)C4CC4)c3)c2)cn1 CHEMBL5276314 IC50 2.5 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(NC(=O)[C@@H]2CC[C@@H](O)C2)c1 CHEMBL5270059 IC50 2.5 nM
O=C(Nc1cncc(-c2cccc(F)c2F)c1)c1ccnc(NC(=O)C2CCC(F)(F)C2)c1 CHEMBL5269369 IC50 2.5 nM
O=C(Nc1cnccc1OCC(F)(F)F)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5276348 IC50 2.5 nM
COc1cccc(-n2ncc3c(N/N=C/c4ccc(S(C)(=O)=O)cc4)ncnc32)c1 CHEMBL66292 pIC50 2.512 nM
COc1cccc(-n2ncc3c(N/N=C/c4ccc(N)cc4)ncnc32)c1 CHEMBL303630 pIC50 2.512 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1977223 pKi 2.512 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccc[nH]2)C(=O)N3)c1)Cc1ccccc1 CHEMBL1980407 pKi 2.512 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3cccc(F)c3F)cc12 CHEMBL1985406 pKi 2.512 nM
O=C(NCc1ccccc1)c1c[nH]n2c(=O)cc(-c3ccncc3)nc12 CHEMBL1974250 pKi 2.512 nM
Cn1c(N2CCNC(c3ccccc3Cl)C2)nc(-c2ccncn2)cc1=O CHEMBL4073837 IC50 2.6 nM
O=C(Nc1cncc(-c2cccc(F)c2F)c1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5285048 IC50 2.6 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 2.62 nM
C[C@@H]1CN(c2ccc(C#N)cc2)CCN1c1nc(-c2ccncn2)cc(=O)n1C CHEMBL4093559 IC50 2.7 nM
COc1ccc(Cn2ncc(NC(=O)c3cc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)ccc3C)c2N)cc1 CHEMBL1684800 IC50 2.73 nM
O=C(/C=C/c1cnc2[nH]cc(-c3ccncc3)c2c1)NCc1ccncc1 CHEMBL4449746 IC50 2.75 nM
Cn1cc(C2=C(c3cn(CCCSC(=N)N)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL6291 IC50 2.8 nM
CC(C)C(=O)Nc1cc(C(=O)Nc2cnccc2OCCC(C)(C)O)ccn1 CHEMBL5268820 IC50 2.8 nM
O=C(Nc1cnccc1-c1ccc(Cl)cc1F)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5281592 IC50 2.8 nM
COc1ccc([C@H]2CN(c3nc(-c4ccncn4)cc(=O)n3C)CCO2)cc1 CHEMBL3091538 IC50 2.9 nM
CN(C)c1nc2ccc1CCCn1cc(c3ccccc31)C1=C(C(=O)NC1=O)c1cn(c3ccccc13)CC2 CHEMBL1162963 IC50 3.0 nM
O=C(O)c1ccc(Nc2ncc([N+](=O)[O-])c(NC34CC5CC(CC(O)(C5)C3)C4)n2)cc1 CHEMBL402902 IC50 3.0 nM
COc1ccc(C2=NNC(=O)/C2=N\Nc2ccc(N3CCOCC3)cc2)cc1OC CHEMBL1086735 Ki 3.0 nM
COc1ccncc1C1=NNC(=O)/C1=N\Nc1ccc(Cl)cc1 CHEMBL1088021 Ki 3.0 nM
CC(C)(O)C(=O)N1CCN(c2ccc(C(F)(F)F)c(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c2)CC1 CHEMBL1650951 IC50 3.0 nM
O=C(NCCCn1ccnc1)c1ccc(O)c2[nH]c(-c3ccc(F)c(Cl)c3)nc12 CHEMBL1957956 IC50 3.0 nM
CCS(=O)(=O)Nc1ccc(CCNC(=O)c2ccnc3[nH]c(-c4ccsc4)nc23)cc1 CHEMBL2048662 IC50 3.0 nM
CS(=O)(=O)Nc1ccc(CCNC(=O)c2ccnc3[nH]c(-c4ccoc4)nc23)cc1 CHEMBL2048670 IC50 3.0 nM
CCN(CC)c1ccc(-c2nc3c(C(=O)Nc4cnccc4C)ccnc3[nH]2)cc1 CHEMBL2048676 IC50 3.0 nM
COc1ccncc1NC(=O)c1ccnc2[nH]c(-c3ccc(F)cc3)nc12 CHEMBL2048677 IC50 3.0 nM
COc1cccc(-c2nc3c(C(=O)Nc4cnccc4C)ccnc3[nH]2)c1 CHEMBL2048681 IC50 3.0 nM
CCOc1ccncc1NC(=O)c1ccnc2[nH]c(-c3cccnc3)nc12 CHEMBL2048682 IC50 3.0 nM
N#Cc1sc(NC2CCCN(c3nc(-c4ccc(Cl)cc4Cl)cn4nc(C(=O)O)cc34)C2)nc1N CHEMBL3647955 IC50 3.0 nM
COc1cc(C2=C(c3cn(CCO)c4ccccc34)C(=O)NC2=O)cc(OC)c1OC CHEMBL3969156 IC50 3.0 nM
CN(C)c1nc2ccc1CCCCn1cc(c3ccccc31)C1=C(C(=O)NC1=O)c1cn(c3ccccc13)CCC2 CHEMBL1231352 IC50 3.0 nM
NC(=O)c1nc(C2CC2)c(-c2ccnc(NC(=O)C3CC3)c2)[nH]1 CHEMBL4483032 IC50 3.0 nM
NC(=O)c1nc(C2CCCCC2)c(-c2ccnc(NC(=O)C3CC3)c2)[nH]1 CHEMBL4526183 IC50 3.0 nM
NC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCCC1CCN(Cc2ccc(F)cc2)CC1 CHEMBL4747992 IC50 3.0 nM
Nc1nccc(CNC(=O)c2ccc3c(c2)/C(=C/Cc2cccc(C(=O)O)c2)C(=O)N3)n1 CHEMBL5186457 IC50 3.0 nM
O=C(Nc1cncc(-c2ccccc2F)c1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5266186 IC50 3.0 nM
Cc1cnc(-c2cnc(NCCNc3ccc(C#N)cn3)nc2-c2ccc(Cl)cc2Cl)[nH]1 CHEMBL412142 IC50 3.0 nM
COc1ccc(CSc2nnc(-c3ccc4ncsc4c3)o2)cc1C(F)(F)F CHEMBL499006 IC50 3.1 nM
CN1CCN(C(=O)c2ccc(-c3cnc(N)c(C(=O)Nc4cccnc4)n3)cc2)CC1 CHEMBL2177168 Ki 3.1 nM
Cn1c(N2CCO[C@@H]3COC[C@H]32)nc(-c2ccncc2F)cc1=O CHEMBL3401132 IC50 3.1 nM
C(=N/Nc1ncnc2c1cnn2-c1ccncc1)\c1ccncc1 CHEMBL308454 pIC50 3.162 nM
Cc1ccc(Nc2nccc(Nc3ccccc3C(=O)O)n2)cc1F CHEMBL243518 pKi 3.162 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL2005936 pKi 3.162 nM
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1973540 pKi 3.162 nM
Nc1nnc(-c2cc3c(Oc4ccc(Cl)cc4)cncc3s2)o1 CHEMBL1994830 pKi 3.162 nM
Cn1cc(C2=C(c3cccc(C[C@@H](O)CO)c3)C(=O)NC2=O)c2ccccc21 CHEMBL1081294 IC50 3.2 nM
Cn1c(N2CCO[C@@H](c3ccccc3F)C2)nc(-c2ccncn2)cc1=O CHEMBL3091539 IC50 3.2 nM
COc1ccncc1NC(=O)c1ccnc(NC(=O)C2CC2)c1 CHEMBL4213175 IC50 3.4 nM
Cn1cc(C2=C(c3coc4cc(O)ccc34)C(=O)NC2=O)c2cc(F)ccc21 CHEMBL489210 IC50 3.5 nM
COc1ccc(-c2coc3ccc(-c4nnc(SCc5cccc(C#N)c5)o4)cc23)cc1 CHEMBL471833 IC50 3.5 nM
COc1ccc(C2CN(c3nc(-c4ccncn4)cc(=O)n3C)CCN2)cc1 CHEMBL4096472 IC50 3.5 nM
O=C(/C=C/c1cnc2[nH]cc(-c3ccccc3)c2c1)NCc1ccncc1 CHEMBL4463440 IC50 3.59 nM
Cn1cc(C2=C(c3ccccc3Cl)C(=O)NC2=O)c2ccccc21 CHEMBL431933 IC50 3.6 nM
O=C(Nc1cnccc1C(O)C(F)(F)F)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5277764 IC50 3.6 nM
COc1cccc(N/N=C2\C(=O)NN=C2c2cnccc2OC)c1 CHEMBL1076755 Ki 3.7 nM
O=C1NC(=O)C(c2cn3c4c(cc(F)cc24)CNCC3)=C1c1coc2ccccc12 CHEMBL2386088 IC50 3.7 nM
Cn1c(N2CCO[C@@H]3CCCC[C@H]32)nc(-c2ccncc2F)cc1=O CHEMBL3401131 IC50 3.7 nM
O=C(Nc1cncc(-c2cc(F)ccc2F)c1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5291257 IC50 3.7 nM
O=C(Nc1cnccc1-c1ccccc1Cl)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5280241 IC50 3.7 nM
Cn1cc(-c2ccc3cnc(NC(=O)C4CCN(S(C)(=O)=O)CC4)cc3c2)cn1 CHEMBL5285332 Kd 3.745 nM
C[C@@H]1CN(c2ccncc2)CCN1c1nc(-c2ccncn2)cc(=O)n1C CHEMBL4065956 IC50 3.8 nM
N#Cc1ccc(Nc2nccc(C(=O)Nc3cnccc3-c3ccccc3)n2)c(Cl)c1 CHEMBL5428489 IC50 3.8 nM
Cc1n[nH]c2ncc(-c3nnc4n3[C@H](c3ccc(Cl)cc3)CC4)cc12 CHEMBL5425043 Kd 3.8 nM
C[C@@H]1CN(c2cccnc2)CCN1c1nc(-c2ccncn2)cc(=O)n1C CHEMBL4067170 IC50 3.9 nM
O=C(Nc1cncc(-c2cncc(Cl)c2)c1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5276201 IC50 3.9 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(Nc2c(F)cc(Cl)cc2F)n1 CHEMBL5434336 IC50 3.9 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnc2ccc(Br)cn12 CHEMBL393525 Kd 3.934 nM
CCNCc1ccc(/C=N/Nc2ncnc3c2cnn3-c2cccc(OC)c2)cc1 CHEMBL66791 pIC50 3.981 nM
COc1cccc(-n2ncc3c(N/N=C/c4cccc(S(C)(=O)=O)c4)ncnc32)c1 CHEMBL66453 pIC50 3.981 nM
N#Cc1ccc(NC(=O)Nc2ccnc3cc(C(F)(F)F)ccc23)nc1 CHEMBL1999718 pKi 3.981 nM
O=C(Nc1cnccn1)Nc1ccnc2ccc(C(F)(F)F)cc12 CHEMBL1976455 pKi 3.981 nM
N#Cc1cccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)c1 CHEMBL1977128 pKi 3.981 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(Cl)c1 CHEMBL1983595 pKi 3.981 nM
Cc1nnc(-c2cc3c(Oc4ccc(C(F)(F)F)cc4)cncc3s2)o1 CHEMBL1988153 pKi 3.981 nM
CN1CCN(c2cnc(NCCNc3ccc([N+](=O)[O-])c(N)n3)nc2-c2ccc(Cl)cc2Cl)C(=O)C1 CHEMBL427882 pIC50 3.981 nM
O=C1Cc2c([nH]c3ccc([N+](=O)[O-])cc23)-c2ccccc2N1 CHEMBL50894 pIC50 3.981 nM
CC(=O)O/N=C1C(=C2/C(=O)Nc3cc(Cl)c(Cl)cc32)/Nc2ccccc2/1 CHEMBL253769 pIC50 3.981 nM
COc1ccccc1C1=C(c2cn(CCCO)c3ncccc23)C(=O)NC1=O CHEMBL111298 IC50 4.0 nM
CCN1CCOCCOCCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CC1 CHEMBL103506 IC50 4.0 nM
CN1CCCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCOCCOCC1 CHEMBL321315 IC50 4.0 nM
CCN1CCN(CCCC(=O)Nc2n[nH]c3nc(-c4ccc(O)cc4)c(Br)cc23)CC1 CHEMBL407981 IC50 4.0 nM
COc1cccc(C2=NNC(=O)/C2=N\Nc2ccc(C#N)cc2)c1 CHEMBL1082009 Ki 4.0 nM
CCS(=O)(=O)Nc1ccc(CCNC(=O)c2ccnc3[nH]c(-c4ccc(F)cc4)nc23)cc1 CHEMBL2048659 IC50 4.0 nM
O=C1Nc2ccccc2/C1=C1/Nc2cc(Br)ccc2C1=O CHEMBL1830063 IC50 4.0 nM
O=C1Nc2ccccc2/C1=C1/Nc2ccccc2C1=O CHEMBL1276127 IC50 4.0 nM
O=C1Cc2c([nH]c3ccccc23)-c2ccccc2N1 CHEMBL430574 IC50 4.0 nM
CC(C)Oc1cncc(-c2ccc3[nH]nc(C(=O)NCC4CCOCC4)c3c2)c1 CHEMBL4632807 IC50 4.0 nM
O=C(NCC1CCOCC1)c1n[nH]c2ccc(-c3cncc(CO)c3)cc12 CHEMBL4640019 IC50 4.0 nM
O=C1NCCC12CCN(c1c(Cl)cncc1-c1cc3ccccc3s1)CC2 CHEMBL4791586 Ki 4.0 nM
CC(C)Oc1cccc(-c2ccc3[nH]nc(C(=O)NCC4CCOCC4)c3c2)c1 CHEMBL5203304 IC50 4.0 nM
CCOc1ccncc1NC(=O)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5286900 IC50 4.0 nM
C[C@@H]1CN(c2ccccn2)CCN1c1nc(-c2ccncn2)cc(=O)n1C CHEMBL4093930 IC50 4.1 nM
O=C(Nc1cncc(-c2ccccc2)c1)c1ccnc(NC(=O)C2CC(F)(F)C2)c1 CHEMBL5271312 IC50 4.1 nM
O=C(Nc1cncc(-c2ccccc2Cl)c1)c1ccnc(NC(=O)C2CCC(F)(F)C2)c1 CHEMBL5272462 IC50 4.1 nM
O=C1Nc2ccccc2/C1=C/c1ccccn1 CHEMBL2094331 IC50 4.19 nM
O=C1NC(=O)C(c2cn3c4c(cccc24)CNCC3)=C1c1coc2ccccc12 CHEMBL368248 IC50 4.2 nM
Cn1c(N2CCO[C@@H]3CCC[C@H]32)nc(-c2ccncc2F)cc1=O CHEMBL3401129 IC50 4.2 nM
C[C@@H]1CN(c2ccccc2C#N)CCN1c1nc(-c2ccncn2)cc(=O)n1C CHEMBL4101293 IC50 4.2 nM
CC(C)(C)C(=O)Nc1cc(C(=O)Nc2cnccc2N2CCC(F)(F)CC2)ccn1 CHEMBL5276840 IC50 4.2 nM
O=C(Nc1cnccc1Oc1ccccc1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5284458 IC50 4.2 nM
O=C(Nc1cnccc1OCCO)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5273478 IC50 4.2 nM
O=C1Nc2ccccc2C1Cc1cccnc1 CHEMBL5284455 IC50 4.2 nM
Cn1c(N2CCNC(c3ccccc3Br)C2)nc(-c2ccncn2)cc1=O CHEMBL4089702 IC50 4.3 nM
Cn1c(N2CCNC(c3ccc(Cl)c(Cl)c3)C2)nc(-c2ccncc2)cc1=O CHEMBL4100923 IC50 4.3 nM
Nc1ncc(-c2ccc(S(=O)(=O)N3CCCC3)cc2)nc1C(=O)Nc1cccnc1 CHEMBL2177162 Ki 4.4 nM
CC(C)Oc1cc(-c2ccnc(NC(=O)C3CC3)c2)ncc1C(N)=O CHEMBL3410107 IC50 4.4 nM
C=C(C)c1ccncc1NC(=O)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5265899 IC50 4.4 nM
NC(=O)c1ccc(-c2c[nH]c3ncc(/C=C/C(=O)NCc4ccncc4)cc23)cc1 CHEMBL4543687 IC50 4.43 nM
COc1ccncc1C1=NNC(=O)/C1=N\Nc1ccccc1 CHEMBL1086736 Ki 4.5 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(NC(=O)C2CCOCC2)c1 CHEMBL5283804 IC50 4.5 nM
COc1cccc([C@H]2CN(c3nc(-c4ccncn4)cc(=O)n3C)CCO2)c1 CHEMBL3091464 IC50 4.6 nM
CC(C)C(=O)Nc1cc(C(=O)Nc2cncc(-c3cc(F)ccc3F)c2)ccn1 CHEMBL5273399 IC50 4.6 nM
O=C1NCCOc2cc(-c3ccnc(NC(=O)C4CC4)c3)ccc21 CHEMBL3410097 IC50 4.7 nM
COc1ccc(C2CN(c3nc(-c4ccncc4)cc(=O)n3C)CCN2)cc1 CHEMBL4078436 IC50 4.7 nM
N#Cc1ccc(-c2ccncc2NC(=O)c2ccnc(NC(=O)C3CC3)c2)cc1 CHEMBL5272425 IC50 4.7 nM
Cc1ccc(-c2ccncc2NC(=O)c2ccnc(NC(=O)C3CC3)c2)cc1 CHEMBL5287898 IC50 4.7 nM
O=C1NC(=O)C(c2cn(CCO)c3ccc(F)cc23)=C1c1coc2ccccc12 CHEMBL2386096 IC50 4.8 nM
O=C(Nc1cncc(-c2ccncc2)c1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5285396 IC50 4.8 nM
COc1ccc(CSc2nnc(-c3ccc4occc4c3)o2)cc1C(F)(F)F CHEMBL471430 IC50 4.9 nM
C[C@@H]1[C@@H](C)OCCN1c1nc(-c2ccncc2F)cc(=O)n1C CHEMBL3401127 IC50 4.9 nM
CC(C)C(=O)N1CCn2cc(C3=C(c4cnc5ccccn45)C(=O)NC3=O)c3cccc(c32)C1 CHEMBL368246 IC50 5.0 nM
O=C(Nc1ncnc2oc(-c3cccnc3)cc12)C1CC1 CHEMBL361196 IC50 5.0 nM
O=C(Nc1ncnc2oc(-c3cccnc3)cc12)C1CCCC1 CHEMBL182419 IC50 5.0 nM
O=C1NC(=O)C(c2cn(CCCO)c3ncccc23)=C1c1cnccn1 CHEMBL272629 IC50 5.0 nM
O=C(Nc1n[nH]c2ncc(-c3ccccc3)cc12)C1CCCC1 CHEMBL258483 IC50 5.0 nM
O=C(Nc1n[nH]c2nc(-c3ccc(O)c(Br)c3)ccc12)C1CC1 CHEMBL260416 IC50 5.0 nM
CCN1CCN(CCCCC(=O)Nc2n[nH]c3nnc(-c4ccccc4)cc23)CC1 CHEMBL259271 IC50 5.0 nM
O=C(CCCN1CCOCC1)Nc1n[nH]c2nnc(-c3ccccc3)cc12 CHEMBL261518 IC50 5.0 nM
O=[N+]([O-])c1ccc(Nc2nccc(-c3cnn4ncccc34)n2)cc1 CHEMBL188938 IC50 5.0 nM
N#Cc1ccc(Nc2nccc(-c3cnn4ncccc34)n2)cc1 CHEMBL359794 IC50 5.0 nM
CCCC(=O)Nc1n[nH]c2cc(-c3ccc(O)cc3)c(Br)cc12 CHEMBL1093747 IC50 5.0 nM
COc1cccc(N/N=C2\C(=O)NN=C2c2cccc(OC)c2)c1 CHEMBL1081833 Ki 5.0 nM
Cn1cc(C2=C(C(=O)CBr)C(=O)NC2=O)c2ccccc21 CHEMBL1801637 IC50 5.0 nM
O=C1Nc2cc(Br)ccc2/C1=c1/[nH]c2ccccc2/c1=C\O CHEMBL3125370 IC50 5.0 nM
N#Cc1sc(NCCNc2nc(-c3ccc(Cl)cc3Cl)cn3nc(C(=O)NCC(=O)O)cc23)nc1N CHEMBL3647956 IC50 5.0 nM
CN1CCN(CCO/N=C2C(=C3/C(=O)Nc4cc(Br)ccc43)/Nc3ccccc3/2)CC1 CHEMBL492244 IC50 5.0 nM
O=C1Cc2cc(Br)ccc2/C1=c1/[nH]c2ccccc2/c1=C\O CHEMBL4077172 IC50 5.0 nM
NC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCC1CCN(Cc2c(F)cccc2F)CC1 CHEMBL4755445 IC50 5.0 nM
CNC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCC1CCN(Cc2cccc([N+](=O)[O-])c2)CC1 CHEMBL4792678 IC50 5.0 nM
O=c1sn(-c2cccc3ccccc23)c(=O)n1Cc1ccccc1 CHEMBL3545157 IC50 5.0 nM
O=C1Nc2cc(Br)ccc2/C1=C1\Nc2ccccc2\C1=N/O CHEMBL5410800 IC50 5.0 nM
CC1(C)CC(=O)C2=C(C1)Nc1n[nH]c(C3CC3)c1[C@]2(C)c1ccccc1 CHEMBL5426906 IC50 5.0 nM
COc1cccc(-n2ncc3c(N/N=C/c4ccc(CN(C)C)cc4)ncnc32)c1 CHEMBL63915 pIC50 5.012 nM
COc1cccc(-n2ncc3c(N/N=C/c4ccc(NC(=O)CCN(C)C)cc4)ncnc32)c1 CHEMBL309152 pIC50 5.012 nM
N#Cc1ccc(F)c(-c2c[nH]c(=O)c3cc(-c4ccncc4)sc23)c1 CHEMBL1809113 pIC50 5.012 nM
COc1ccc(-c2ocnc2C(=O)NCc2ccn3ccnc3c2)cc1Cl CHEMBL1957231 pIC50 5.012 nM
O=C(Nc1cnccn1)Nc1ccnc2c(F)cccc12 CHEMBL1975647 pKi 5.012 nM
COc1ccccc1C(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1997643 pKi 5.012 nM
Cn1cc(Nc2ncc(Br)c(Nc3ccccc3C(N)=O)n2)cn1 CHEMBL1994669 pKi 5.012 nM
O=C1Nc2ccc(Br)cc2/C1=C1/Nc2ccccc2/C1=N\O CHEMBL253770 pIC50 5.012 nM
Cn1cc(C2=C(c3coc4cc(CO)ccc34)C(=O)NC2=O)c2cccc(CO)c21 CHEMBL491447 IC50 5.1 nM
Cc1cc2c3c(c1)c(C1=C(c4cnc5ccccn45)C(=O)NC1=O)cn3CCN(C(=O)N1CCCCC1)C2 CHEMBL186290 IC50 5.2 nM
COc1ccc(C2CN(c3nc(-c4ccncc4)cc(=O)n3C)CCN2)cc1OC CHEMBL4062791 IC50 5.2 nM
Cc1ccc2ncc(C3=C(c4cn5c6c(cccc46)CN(C=O)C(N4CCCCC4)C5)C(=O)NC3=O)n2c1 CHEMBL4161007 IC50 5.2 nM
O=C(Nc1cnccc1-c1ccc(F)cc1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5288565 IC50 5.2 nM
Cn1cc(C2=C(c3cnc4ccccn34)C(=O)NC2=O)c2cc3c(cc21)OCO3 CHEMBL2386112 IC50 5.3 nM
Cn1cc(C2=C(c3coc4ccccc34)C(=O)NC2=O)c2cc(Br)cnc21 CHEMBL2386106 IC50 5.3 nM
CN1CCN(c2ccc(Nc3nccc(-c4cnn5ncccc45)n3)cc2C(F)(F)F)CC1 CHEMBL468963 Kd 5.3 nM
Cn1cc(C2=C(c3coc4ccccc34)C(=O)NC2=O)c2cccc(CO)c21 CHEMBL522464 IC50 5.4 nM
Cn1c(N2CCNC(c3cccc(Cl)c3)C2)nc(-c2ccncc2)cc1=O CHEMBL4080891 IC50 5.4 nM
NCCO/N=C1C(=C2/C(=O)Nc3ccc([N+](=O)[O-])cc32)/Nc2ccc(O)cc2/1 CHEMBL4763626 IC50 5.46 nM
O=C1N[C@H]2C[C@@H](C2)OCc2cccc(n2)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)O1 CHEMBL5267053 IC50 5.5 nM
CC(C)C(=O)Nc1cc(C(=O)Nc2cncc(-c3ccccc3F)c2)ccn1 CHEMBL5280453 IC50 5.6 nM
COc1ccc(CSc2nnc(-c3ccc4c(c3)CCO4)o2)cc1C(F)(F)F CHEMBL512144 IC50 5.7 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(NC(=O)C2CCC2)c1 CHEMBL5267564 IC50 5.7 nM
Cn1cc(/C=C2\Oc3cccc(O)c3C2=O)c2c(-c3ccc(C(=O)NCCO)cc3)ccnc21 CHEMBL1092754 IC50 5.9 nM
COc1nc(-c2ccnc(NC(=O)C3CC3)c2)ncc1C(N)=O CHEMBL3410110 IC50 5.9 nM
O=C(Nc1cnccc1-c1ccc(Cl)cc1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5278465 IC50 5.9 nM
O=C(Nc1cnccc1-c1ccc(OC(F)F)cc1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5289893 IC50 5.9 nM
O=C1NC(=O)C(c2cn(CCCO)c3ncccc23)=C1c1ccc(F)cc1Cl CHEMBL111005 IC50 6.0 nM
CN1CCOCCN(C)CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CC1 CHEMBL105477 IC50 6.0 nM
Cc1cc2c(NC(=O)C3CC3)n[nH]c2nc1-c1ccc(O)cc1 CHEMBL260662 IC50 6.0 nM
CCCC(=O)Nc1n[nH]c2c(F)c(Cl)c(-c3ccccc3)cc12 CHEMBL1086427 IC50 6.0 nM
O=C(NCCCn1cnc(Cl)c1Cl)c1ccc(O)c2[nH]c(-c3ccc(Cl)cc3Cl)nc12 CHEMBL1957955 IC50 6.0 nM
Cc1cc(Nc2n[nH]c3ncc(F)cc23)nc(C2CCCCC2)n1 CHEMBL3652545 IC50 6.0 nM
O=C(O)c1coc(CN2CCC(CNC(=O)c3n[nH]c4ccc(-c5cccc(F)c5F)cc34)CC2)n1 CHEMBL3735986 IC50 6.0 nM
COCc1cncc(-c2ccc3[nH]nc(C(=O)NCC4CCOCC4)c3c2)c1 CHEMBL4643920 IC50 6.0 nM
C#Cc1ccc2c(c1)[nH]c1ncnc(N(C)[C@H]3CCCN(CCC#N)C3)c12 CHEMBL5089934 IC50 6.0 nM
CNC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCF CHEMBL5287270 IC50 6.0 nM
COc1ccccc1[C@H]1CN(c2cc(-c3ccncn3)cc(=O)n2C)CCO1 CHEMBL1682851 IC50 6.1 nM
COc1ccc2c(c1C(C)N1CCNCC1)O/C(=C\c1n[nH]c3ncccc13)C2=O CHEMBL3735890 IC50 6.1 nM
CC(C)CN1CCC(C(=O)Nc2cc3cc(-c4cnn(C)c4)ccc3cn2)CC1 CHEMBL5289681 Kd 6.214 nM
Cc1cc(-c2cnc(N)c(C(=O)Nc3cccnc3)n2)ccc1S(=O)(=O)N1CCN(C)CC1 CHEMBL2177158 Ki 6.3 nM
COc1cccc(-n2ncc3c(N/N=C/c4ccncc4)ncnc32)c1 CHEMBL306865 pIC50 6.31 nM
COc1cccc(-n2ncc3c(N/N=C/c4ccc(OCCN(C)C)cc4)ncnc32)c1 CHEMBL303321 pIC50 6.31 nM
O=c1[nH]cc(-c2ccc3c(c2)OCCO3)c2sc(-c3ccncc3)cc12 CHEMBL1809114 pIC50 6.31 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1Cl CHEMBL1965660 pKi 6.31 nM
CCCc1ccc2nccc(NC(=O)Nc3cccc(C(F)(F)F)n3)c2c1 CHEMBL1987430 pKi 6.31 nM
NC(=O)c1cc2c(-c3ccc(Br)c(F)c3F)cncc2s1 CHEMBL1999918 pKi 6.31 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 6.31 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2c(C(F)(F)F)cccc12 CHEMBL1980142 pKi 6.31 nM
CN(C)CC(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1965631 pKi 6.31 nM
COc1cccc(C2=C(c3cn(C)c4ccc(Cl)cc34)C(=O)NC2=O)c1 CHEMBL1081617 IC50 6.4 nM
O=C(Nc1cncc(-c2ccc(F)cc2)c1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5272358 IC50 6.4 nM
COc1ccc(CSc2nnc(C3=CC=C4NC=CN4C3)o2)cc1C(F)(F)F CHEMBL513878 IC50 6.5 nM
COc1cccc(C2=NNC(=O)/C2=N\Nc2ccc(C(=O)O)cc2)c1 CHEMBL1082188 Ki 6.5 nM
Cn1c(N2CCO[C@@H](c3ccc(C#N)cc3F)C2)nc(-c2ccncn2)cc1=O CHEMBL3091543 IC50 6.5 nM
NC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCc1cn(-c2c3c(nc4ccccc24)CCCC3)nn1 CHEMBL4747410 IC50 6.5 nM
COc1ccc(C2=C(c3cn(C)c4ccccc34)C(=O)NC2=O)cc1OC CHEMBL1087242 IC50 6.6 nM
Cn1c(N2CCNC(c3ccc(Cl)cc3)C2)nc(-c2ccncc2)cc1=O CHEMBL4080483 IC50 6.6 nM
COc1cccc(C2CN(c3nc(-c4ccncn4)cc(=O)n3C)CCN2)c1 CHEMBL4097431 IC50 6.7 nM
NC(=O)c1cnc(-c2ccnc(NC(=O)C3CC3)c2)cc1OCC(F)(F)F CHEMBL3410106 IC50 6.8 nM
O=C(Nc1cnccc1-c1ccc(Cl)cc1)c1ccnc(NC(=O)[C@H]2C[C@@H](F)C2)c1 CHEMBL5281994 IC50 6.9 nM
COc1ccccc1C1=C(c2cn(CCCNC(=O)OC(C)(C)C)c3ncccc23)C(=O)NC1=O CHEMBL109981 IC50 7.0 nM
Cn1cc(C2=C(c3ccc(Cl)cc3Cl)C(=O)NC2=O)c2ccccc21 CHEMBL102714 IC50 7.0 nM
CN(C)c1cc2cc(n1)CCCn1cc(c3ccccc31)C1=C(C(=O)NC1=O)c1cn(c3ccccc13)CCC2 CHEMBL247067 IC50 7.0 nM
O=C(Nc1n[nH]c2nc(-c3ccco3)c(Br)cc12)C1CC1 CHEMBL408564 IC50 7.0 nM
CCCC(=O)Nc1n[nH]c2ncc(-c3cccc(F)c3F)cc12 CHEMBL264161 IC50 7.0 nM
O=C(Nc1n[nH]c2nc(-c3cccs3)c(Br)cc12)C1CCCC1 CHEMBL407980 IC50 7.0 nM
O=C(Nc1n[nH]c2nc(-c3ccc(O)c(Cl)c3)ccc12)C1CC1 CHEMBL259838 IC50 7.0 nM
CCN1CCN(CCCC(=O)Nc2n[nH]c3nnc(-c4ccccc4)cc23)CC1 CHEMBL409738 IC50 7.0 nM
CCCC(=O)Nc1n[nH]c2cnc(-c3ccccc3)cc12 CHEMBL261549 IC50 7.0 nM
O=C(O)/C=C\c1ccc(Nc2ncc3nnn(-c4ccccc4)c3n2)cc1 CHEMBL255735 IC50 7.0 nM
Cn1cc(C2=C(c3coc4ccccc34)C(=O)NC2=O)c2cc(Br)ccc21 CHEMBL489422 IC50 7.0 nM
Cn1cc(C2=C(c3cc(Cl)ccc3Cl)C(=O)NC2=O)c2ccccc21 CHEMBL562023 IC50 7.0 nM
CCCC(=O)Nc1n[nH]c2cc(Cl)c(-c3ccccc3)cc12 CHEMBL1095040 IC50 7.0 nM
CN(C)c1nc2ccc1CCCN1C=C(C3=C(C(=O)NC3=O)c3cn(c4ccccc34)CCC2)N2C=CC=CC12 CHEMBL1087499 IC50 7.0 nM
COc1ccc(Nc2nnc(-c3ccc([N+](=O)[O-])cc3)o2)cc1 CHEMBL1630488 IC50 7.0 nM
CS(=O)(=O)Nc1ccc(CCNC(=O)c2ccc(O)c3[nH]c(-c4ccc(Cl)cc4)nc23)cc1 CHEMBL1957947 IC50 7.0 nM
CCOc1ccncc1NC(=O)c1ccnc2[nH]c(-c3cccc(OC)c3)nc12 CHEMBL2048683 IC50 7.0 nM
C[C@@H]1COCCN1c1nc(-c2ccncc2F)cc(=O)n1C CHEMBL3401118 IC50 7.0 nM
COc1cc(-c2ccnc(NC(=O)C3CC3)c2)cnc1C(N)=O CHEMBL3410104 IC50 7.0 nM
CNC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OC1CCN(Cc2ccccc2)CC1 CHEMBL4752296 IC50 7.0 nM
Cn1c(N2CCO[C@@H](c3ccc(F)cc3)C2)nc(-c2ccncc2F)cc1=O CHEMBL3091531 IC50 7.4 nM
Cn1c(N2CCNC(c3ccc(C#N)cc3)C2)nc(-c2ccncn2)cc1=O CHEMBL4089283 IC50 7.4 nM
COc1cccc2c(C3=C(c4cn(C)c5ccc(Br)cc45)C(=O)NC3=O)coc12 CHEMBL505673 IC50 7.5 nM
O=C(Nc1cc(-c2ccc3ncccc3c2)ccn1)C1CC1 CHEMBL3410101 IC50 7.5 nM
O=C(Nc1cnccc1C1CCC1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5268992 IC50 7.5 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1 CHEMBL3301610 Kd 7.673 nM
O=C1NC(=O)C(c2cnc3ccccn23)=C1c1cn2c3c(cccc13)CN(C(=O)C1CCOCC1)CC2 CHEMBL181339 IC50 7.7 nM
COc1ccncc1C1=NNC(=O)/C1=N\Nc1ccc(C(=O)O)cc1 CHEMBL1081446 Ki 7.7 nM
O=C(NCc1cccc(O)c1)Nc1nc(-c2ccncc2)cs1 CHEMBL3218297 IC50 7.77 nM
COc1ccc(C2CN(c3nc(-c4ccncn4)cc(=O)n3C)CCN2)cc1OC CHEMBL4082944 IC50 7.8 nM
COc1cccc(-n2ncc3c(N/N=C/c4cccc(F)c4)ncnc32)c1 CHEMBL69757 pIC50 7.943 nM
COc1cccc(-n2ncc3c(N/N=C/c4ccc(F)cc4)ncnc32)c1 CHEMBL65884 pIC50 7.943 nM
COc1cccc(-n2ncc3c(N/N=C/c4ccc(C(=O)NCCS(C)(=O)=O)cc4)ncnc32)c1 CHEMBL65987 pIC50 7.943 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2c(F)ccc(F)c12 CHEMBL2001987 pKi 7.943 nM
Cc1cccc(CNc2cc(-c3c[nH]c4ncccc34)ncn2)c1 CHEMBL1995932 pKi 7.943 nM
O=C(Nc1cnccn1)Nc1ccnc2ccccc12 CHEMBL1981720 pKi 7.943 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12 CHEMBL2004631 pKi 7.943 nM
Cn1cc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cn1 CHEMBL1984548 pKi 7.943 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2cc(C(F)(F)F)ccc12 CHEMBL1973483 pKi 7.943 nM
c1ccc(CNc2cc(-c3c[nH]c4ncccc34)ncn2)cc1 CHEMBL2002346 pKi 7.943 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2cc(Cl)ccc12 CHEMBL1981744 pKi 7.943 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 7.943 nM
O=C(Nc1cnccn1)Nc1ccnc2ccc(N3CC4COCC4C3)cc12 CHEMBL2002599 pKi 7.943 nM
COc1ccccc1C1=C(c2cn(CCCNC=O)c3ncccc23)C(=O)NC1=O CHEMBL109977 IC50 8.0 nM
CN1CCOCCOCCN(C)CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CC1 CHEMBL105620 IC50 8.0 nM
O=C(Nc1n[nH]c2nc(-c3ccc(O)c(O)c3)ccc12)C1CC1 CHEMBL260345 IC50 8.0 nM
O=C(Nc1n[nH]c2nc(-c3ccc(O)cc3)ccc12)C1CC1 CHEMBL405145 IC50 8.0 nM
c1cc(Nc2nccc(-c3cnn4ncccc34)n2)cc(-c2cocn2)c1 CHEMBL497564 IC50 8.0 nM
O=C(Nc1n[nH]c2nc(-c3cccc(O)c3)ccc12)C1CC1 CHEMBL408019 IC50 8.0 nM
Cc1cc(Nc2nc(Sc3ccc(Cl)cc3Cl)nc3ccccc23)n[nH]1 CHEMBL551633 Ki 8.0 nM
CCCC(=O)Nc1n[nH]c2cc(Cl)c(-c3ccc(N)cc3)cc12 CHEMBL1095041 IC50 8.0 nM
COc1cccc(C2=NNC(=O)/C2=N\Nc2cccc(Cl)c2)c1 CHEMBL1079968 Ki 8.0 nM
COc1cccc(C2=NNC(=O)/C2=N\Nc2ccccn2)c1 CHEMBL1082010 Ki 8.0 nM
COc1ccc(C2=NNC(=O)/C2=N\Nc2ccc(N3CCOCC3)cc2)cc1 CHEMBL1088725 Ki 8.0 nM
O=C(NCCCn1cnc(Cl)c1Cl)c1ccc(O)c2[nH]c(-c3cccs3)nc12 CHEMBL1957959 IC50 8.0 nM
O=C(Nc1cccnc1)c1ccnc2[nH]c(-c3ccc(F)cc3)nc12 CHEMBL2048665 IC50 8.0 nM
Cc1ccc(NC(=O)c2ccnc3[nH]c(-c4ccc(F)cc4)nc23)cn1 CHEMBL2048679 IC50 8.0 nM
CCOC(=O)c1cc2c(N3CCCC(Nc4nc(N)c(C(C)=O)s4)C3)nc(-c3ccc(Cl)cc3Cl)cn2n1 CHEMBL3647954 IC50 8.0 nM
COCCN1CCN(Cc2ccc(-c3n[nH]c4c3C(=O)c3c(NC(=O)NN5CCOCC5)cccc3-4)cc2)CC1 CHEMBL3545083 Kd apparent 8.0 nM
NC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCCC1CCN(Cc2ccccc2)CC1 CHEMBL4794823 IC50 8.0 nM
CN1CCN(c2ccc(NCCNc3ccc([N+](=O)[O-])c(N)n3)nc2-c2ccc(Cl)cc2Cl)C(=O)C1 CHEMBL1242830 IC50 8.0 nM
Cn1c(N2CCNC(c3ccc(Br)cc3)C2)nc(-c2ccncn2)cc1=O CHEMBL4081408 IC50 8.1 nM
Cn1cc(C2=C(c3cccc(C[C@H](O)CO)c3)C(=O)NC2=O)c2ccccc21 CHEMBL1081972 IC50 8.2 nM
Cn1c(N2CCNC(c3ccccc3F)C2)nc(-c2ccncn2)cc1=O CHEMBL4080416 IC50 8.2 nM
COc1ccncc1C1=NNC(=O)/C1=N\Nc1ccc(C#N)cc1 CHEMBL1081102 Ki 8.3 nM
Cn1cc(C2=C(c3cn(C4CCN(Cc5ccccn5)CC4)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL300138 Kd 8.3 nM
C[C@@H]1CN(Cc2ccccc2)CCN1c1nc(-c2ccncn2)cc(=O)n1C CHEMBL4082198 IC50 8.3 nM
COc1ccc(-c2coc3ccc(-c4nnc(SCc5cccc(C(F)(F)F)c5)o4)cc23)cc1 CHEMBL471832 IC50 8.4 nM
CCN(CCN(C)C)S(=O)(=O)c1ccc(-c2cnc(N)c(C(=O)Nc3cccnc3)n2)cc1 CHEMBL2177167 Ki 8.4 nM
Cn1c(N2CCC(O)(c3ccccc3)CC2)cc(-c2ccncn2)cc1=O CHEMBL1682850 IC50 8.5 nM
COc1ccc(-n2cnc3ccc(-c4nnc(SCc5ccc(OC)c(C(F)(F)F)c5)o4)cc32)cc1 CHEMBL472043 IC50 8.6 nM
Cn1c(N2CCNC(c3ccc(F)cc3)C2)nc(-c2ccncn2)cc1=O CHEMBL4096984 IC50 8.6 nM
O=C1NC(=O)C(c2cnc3cnccn23)=C1c1cn2c3c(cccc13)CN(C(=O)N1CCCCC1)CC2 CHEMBL178851 IC50 8.7 nM
C[C@@H]1CN(c2ccncc2NC(=O)c2ccnc(NC(=O)C3CC3)c2)CCO1 CHEMBL5272013 IC50 8.8 nM
Cn1c(NCC(=O)c2ccccc2)nc(-c2ccncc2)cc1=O CHEMBL3091545 IC50 8.9 nM
O=Nc1c(-c2c(O)[nH]c3ccc(I)cc23)[nH]c2ccccc12 CHEMBL337300 IC50 9.0 nM
CN1CCC(C(=O)Nc2n[nH]c3nnc(-c4ccccc4)cc23)CC1 CHEMBL406125 IC50 9.0 nM
COc1ccc(N/N=C2\C(=O)NN=C2c2cc(OC)c(OC)c(OC)c2)cc1 CHEMBL1082157 Ki 9.0 nM
COc1cccc(C2=NNC(=O)/C2=N\Nc2ccc(Cl)cc2)c1 CHEMBL1076695 Ki 9.0 nM
COc1cccc(C2=NNC(=O)/C2=N\Nc2ccc(N(C)C)cc2)c1 CHEMBL1080847 Ki 9.0 nM
CN(C)S(=O)(=O)Nc1ccc(CCNC(=O)c2ccnc3[nH]c(-c4ccsc4)nc23)cc1 CHEMBL2048672 IC50 9.0 nM
O=C(NCCc1cccnc1Cl)c1ccnc2[nH]c(-c3ccoc3)nc12 CHEMBL2048673 IC50 9.0 nM
CN1CCN(S(=O)(=O)c2ccc(-c3cnc(N)c(C(=O)Nc4cccnc4)n3)cc2F)CC1 CHEMBL2177157 Ki 9.0 nM
COc1cc(C2=C(c3c[nH]c4cnccc34)C(=O)NC2=O)cc(OC)c1OC CHEMBL2180882 IC50 9.0 nM
N#Cc1cccc(-c2nc(Nc3cc(C4CC4)[nH]n3)c3ccccc3n2)c1 CHEMBL4174082 Ki 9.0 nM
NC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCCC1CCN(Cc2cccc(F)c2)CC1 CHEMBL4776811 IC50 9.0 nM
O=C(Nc1cncc(-c2ccccc2)c1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5284249 IC50 9.0 nM
COCCN1CCC(CNC(=O)c2ncc3ccc(-c4cncc(OC(C)C)c4)cn23)CC1 CHEMBL5438428 IC50 9.0 nM
Cn1cnc2ccc(-c3nnc(SCc4cccc(C(F)(F)F)c4)o3)cc21 CHEMBL461261 IC50 9.4 nM
Cc1cncc(NC(=O)c2ccnc(NC(=O)C3CC3)c2)c1 CHEMBL5282618 IC50 9.5 nM
COc1ccncc1-c1ccc2[nH]nc(C(=O)NCC3CCN(Cc4ccc(C(=O)O)o4)CC3)c2c1 CHEMBL3735176 IC50 9.6 nM
Cn1c(N2CCNC(c3ccccc3Cl)C2)nc(-c2ccncc2)cc1=O CHEMBL4104642 IC50 9.6 nM
CC1N(c2nc(-c3ccncc3F)cc(=O)n2C)CCOC1(C)C CHEMBL3401128 IC50 9.7 nM
O=C(Nc1cnccc1-c1ccccc1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL5270581 IC50 9.8 nM