CCOc1cc(Cl)c(-c2ccc(-c3nc4ccc(S(=O)(=O)C5CCN(C)CC5)cc4s3)c(=O)[nH]2)cc1N1CCOCC1 CHEMBL4642043 EC50 5.0 nM
CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(CN4CCN(C)CC4)cc3s2)cc1N1CCCC1 CHEMBL4632482 EC50 13.0 nM
Nc1nc2ccc(O)nc2n1-c1cccc2ccccc12 CHEMBL3717084 EC50 14.0 nM
Nc1nc2ccc(O)nc2n1-c1ccc(Cl)c2ccccc12 CHEMBL3717773 EC50 14.0 nM
Cc1ccc2ccccc2c1-n1c(N)nc2ccc(O)nc21 CHEMBL3718324 EC50 14.0 nM
Cc1ccc2ccccc2c1-n1c(C)nc2ccc(O)nc21 CHEMBL3715748 EC50 14.0 nM
Oc1ccc2ncn(C3CCC(O)CC3)c2n1 CHEMBL3716940 EC50 14.0 nM
O=C1CCCCC1n1cnc2ccc(O)nc21 CHEMBL3716494 EC50 14.0 nM
Oc1ccc2ncn(C3CCCCC3)c2n1 CHEMBL3718239 EC50 14.0 nM
Nc1nc2ccc(O)nc2n1C1CCCCCC1 CHEMBL3716479 EC50 14.0 nM
Oc1ccc2ncn(C3CCCCCCC3)c2n1 CHEMBL3715359 EC50 14.0 nM
Cc1nc2ccc(O)nc2n1C1CCCCCC1 CHEMBL3717920 EC50 14.0 nM
Oc1ccc2ncn(C3CCCCC3O)c2n1 CHEMBL3715599 EC50 14.0 nM
Oc1ccc2ncn(C3CCSCC3)c2n1 CHEMBL3715673 EC50 14.0 nM
Oc1ccc2ncn(C3CC4CCC3C4)c2n1 CHEMBL3716637 EC50 14.0 nM
Oc1ccc2ncn(-c3cccc4c3CCC4)c2n1 CHEMBL3718637 EC50 14.0 nM
Nc1nc2ccc(O)nc2n1-c1cccc2c1CCC2 CHEMBL3719308 EC50 14.0 nM
Oc1ccc2ncn(-c3cccc(Br)c3C(F)(F)F)c2n1 CHEMBL3718131 EC50 14.0 nM
Oc1ccc2nc(Cl)n(-c3ccccc3F)c2n1 CHEMBL3718227 EC50 14.0 nM
Oc1ccc2nc(Br)n(-c3ccccc3F)c2n1 CHEMBL3717420 EC50 14.0 nM
CC(C)(C)OC(=O)N1CCCC(n2cnc3ccc(O)nc32)CC1 CHEMBL3717482 EC50 14.0 nM
Oc1ccc2nc(Br)n(-c3ccccc3Cl)c2n1 CHEMBL3717636 EC50 14.0 nM
Oc1ccc2ncn(-c3ccccc3C3CC3)c2n1 CHEMBL3716302 EC50 14.0 nM
Oc1ccc2ncn(-c3ccccc3OC(F)(F)F)c2n1 CHEMBL3715478 EC50 14.0 nM
Cc1nc2ccc(O)nc2n1-c1ccccc1OC(F)(F)F CHEMBL3717852 EC50 14.0 nM
Nc1nc2ccc(O)nc2n1-c1ccccc1OC(F)(F)F CHEMBL3718085 EC50 14.0 nM
CSc1ccccc1-n1c(C)nc2ccc(O)nc21 CHEMBL3717252 EC50 14.0 nM
Cc1nc2ccc(O)nc2n1-c1ccccc1C(F)(F)F CHEMBL3717608 EC50 14.0 nM
Oc1ccc2ncn(-c3ccccc3-c3ccccc3)c2n1 CHEMBL3717582 EC50 14.0 nM
Oc1ccc2ncn(-c3ccncc3Cl)c2n1 CHEMBL3718240 EC50 14.0 nM
O=[N+]([O-])c1ccccc1-n1cnc2ccc(O)nc21 CHEMBL3715890 EC50 14.0 nM
Oc1ccc2ncn(-c3ccccc3Br)c2n1 CHEMBL3717797 EC50 14.0 nM
Oc1ccc2ncn(-c3c(Cl)cccc3Cl)c2n1 CHEMBL3717469 EC50 14.0 nM
Cc1cc(Br)c(Cl)cc1-n1cnc2ccc(O)nc21 CHEMBL3719226 EC50 14.0 nM
Cc1ccc(Cl)cc1-n1cnc2ccc(O)nc21 CHEMBL3719094 EC50 14.0 nM
Oc1ccc2ncn(C3CCCC3)c2n1 CHEMBL3718624 EC50 14.0 nM
Oc1ccc2ncn(C3CCCCCC3)c2n1 CHEMBL3717555 EC50 14.0 nM
Oc1ccc2ncn(-c3ccc(Cl)cc3Cl)c2n1 CHEMBL3719235 EC50 14.0 nM
Oc1ccc2ncn(-c3cccc(Cl)c3F)c2n1 CHEMBL3718861 EC50 14.0 nM
Oc1ccc2ncn(-c3cccc(C(F)(F)F)c3F)c2n1 CHEMBL3716500 EC50 14.0 nM
Oc1ccc2ncn(-c3cccc(Cl)c3Cl)c2n1 CHEMBL3717347 EC50 14.0 nM
Oc1ccc2ncn(-c3ccc(F)cc3C(F)(F)F)c2n1 CHEMBL3716263 EC50 14.0 nM
Oc1ccc2ncn(-c3ccc(Cl)c(Cl)c3Cl)c2n1 CHEMBL3718374 EC50 14.0 nM
Oc1ccc2ncn(-c3ccc(C(F)(F)F)cc3C(F)(F)F)c2n1 CHEMBL3714909 EC50 14.0 nM
Oc1ccc2ncn(-c3ccc(Br)cc3C(F)(F)F)c2n1 CHEMBL3717689 EC50 14.0 nM
Nc1nc2ccc(O)nc2n1-c1ccccc1F CHEMBL3715394 EC50 14.0 nM
Oc1ccc2ncn(-c3cccc(F)c3F)c2n1 CHEMBL3715218 EC50 14.0 nM
Cc1c(F)cccc1-n1cnc2ccc(O)nc21 CHEMBL3718175 EC50 14.0 nM
Cc1c(Cl)cccc1-n1cnc2ccc(O)nc21 CHEMBL3716993 EC50 14.0 nM
Oc1ccc2ncn(-c3cccc(F)c3Cl)c2n1 CHEMBL3716914 EC50 14.0 nM
Nc1nc2ccc(O)nc2n1-c1cccc(F)c1F CHEMBL3718610 EC50 14.0 nM
Cc1c(F)cccc1-n1c(N)nc2ccc(O)nc21 CHEMBL3717145 EC50 14.0 nM
Cc1c(Cl)cccc1-n1c(N)nc2ccc(O)nc21 CHEMBL3716036 EC50 14.0 nM
Nc1nc2ccc(O)nc2n1-c1cccc(F)c1Cl CHEMBL3715004 EC50 14.0 nM
Cc1cccc(-n2c(N)nc3ccc(O)nc32)c1F CHEMBL3717311 EC50 14.0 nM
Oc1ccc2ncn(C3CCOCC3)c2n1 CHEMBL3716273 EC50 14.0 nM
Oc1ccc2nc(Cl)n(-c3ccccc3Cl)c2n1 CHEMBL3716351 EC50 14.0 nM
O=C1CCCCCC1n1cnc2ccc(O)nc21 CHEMBL3716863 EC50 14.0 nM
Oc1ccc2ncn(C3CCCCCC3O)c2n1 CHEMBL3715611 EC50 14.0 nM
Nc1nc2ccc(O)nc2n1-c1cc(Cl)c(Cl)cc1Cl CHEMBL3715361 EC50 14.0 nM
Cc1nc2ccc(O)nc2n1-c1cc(Cl)c(Cl)cc1Cl CHEMBL3718623 EC50 14.0 nM
Oc1ccc2ncn(-c3cc(Cl)c(Cl)cc3Cl)c2n1 CHEMBL3717694 EC50 14.0 nM
Cc1nc2ccc(O)nc2n1-c1ccc(Cl)c2ccccc12 CHEMBL3717710 EC50 14.0 nM
Oc1ccc2ncn(-c3ccc(Cl)c4ccccc34)c2n1 CHEMBL3715778 EC50 14.0 nM
Cc1cccc(-n2c(C)nc3ccc(O)nc32)c1C CHEMBL3715536 EC50 14.0 nM
Cc1cccc(-n2cnc3ccc(O)nc32)c1C CHEMBL3717573 EC50 14.0 nM
Cc1cccc(-n2c(C)nc3ccc(O)nc32)c1Br CHEMBL3716083 EC50 14.0 nM
Cc1cccc(-n2cnc3ccc(O)nc32)c1Br CHEMBL3718790 EC50 14.0 nM
Cc1nc2ccc(O)nc2n1-c1cccc2ccccc12 CHEMBL3715558 EC50 14.0 nM
Cc1nc2ccc(O)nc2n1-c1ccc(Cl)c(Cl)c1Cl CHEMBL3716994 EC50 14.0 nM
Nc1nc2ccc(O)nc2n1-c1ccc(Cl)c(Cl)c1Cl CHEMBL3714817 EC50 14.0 nM
Cc1ccc2ccccc2c1-n1cnc2ccc(O)nc21 CHEMBL3718300 EC50 14.0 nM
Oc1ccc2ncn(-c3cccc4ccccc34)c2n1 CHEMBL3716441 EC50 14.0 nM
Nc1nc2ccc(O)nc2n1-c1ccccc1C(F)(F)F CHEMBL3717985 EC50 14.0 nM
Cc1cc(Br)ccc1-n1cnc2ccc(O)nc21 CHEMBL3717091 EC50 14.0 nM
CCc1ccccc1-n1cnc2ccc(O)nc21 CHEMBL3716041 EC50 14.0 nM
CC(C)c1ccccc1-n1cnc2ccc(O)nc21 CHEMBL3716287 EC50 14.0 nM
Cc1cccc(C)c1-n1cnc2ccc(O)nc21 CHEMBL3717421 EC50 14.0 nM
Cc1ccc(-n2cnc3ccc(O)nc32)c(C)c1 CHEMBL3717752 EC50 14.0 nM
Oc1ccc2ncn(C3CCC3)c2n1 CHEMBL3719026 EC50 14.0 nM
Oc1ccc2nc(Cl)n(-c3ccccc3)c2n1 CHEMBL3718549 EC50 14.0 nM
Cc1ccccc1-n1c(N)nc2ccc(O)nc21 CHEMBL3718177 EC50 14.0 nM
Oc1ccc2ncn(-c3ccccc3F)c2n1 CHEMBL3717503 EC50 14.0 nM
Oc1ccc2ncn(-c3ccccc3C(F)(F)F)c2n1 CHEMBL3718371 EC50 14.0 nM
Cc1cc(F)ccc1-n1cnc2ccc(O)nc21 CHEMBL3714970 EC50 14.0 nM
COc1ccccc1-n1cnc2ccc(O)nc21 CHEMBL3718354 EC50 14.0 nM
Oc1ccc2ncn(-c3ccccc3Cl)c2n1 CHEMBL3715577 EC50 14.0 nM
Oc1ccc2ncn(-c3ccsc3)c2n1 CHEMBL3718159 EC50 14.0 nM
Nc1nc2ccc(O)nc2n1-c1ccc(Br)cc1 CHEMBL3714885 EC50 14.0 nM
Cc1nc2ccc(O)nc2n1-c1ccc(Br)cc1 CHEMBL3718747 EC50 14.0 nM
Cc1ccc(C)c(-n2cnc3ccc(O)nc32)c1 CHEMBL3716281 EC50 14.0 nM
Cc1cc(C)cc(-n2cnc3ccc(O)nc32)c1 CHEMBL3715915 EC50 14.0 nM
Cc1ccc(-n2cnc3ccc(O)nc32)cc1C CHEMBL3716553 EC50 14.0 nM
Cc1ccccc1-n1cnc2ccc(O)nc21 CHEMBL3718416 EC50 14.0 nM
CSc1nc2ccc(O)nc2n1-c1ccccc1 CHEMBL3719363 EC50 14.0 nM
Cc1ccc(-n2c(C)nc3ccc(O)nc32)cc1 CHEMBL3715017 EC50 14.0 nM
CCc1ccc(-n2c(C)nc3ccc(O)nc32)cc1 CHEMBL3715837 EC50 14.0 nM
Cc1ccc(-n2c(N)nc3ccc(O)nc32)cc1 CHEMBL3718264 EC50 14.0 nM
CCc1ccc(-n2c(N)nc3ccc(O)nc32)cc1 CHEMBL3716501 EC50 14.0 nM
Cc1ccc(-n2cnc3ccc(O)nc32)cc1 CHEMBL3716686 EC50 14.0 nM
COc1ccc(-n2cnc3ccc(O)nc32)cc1 CHEMBL3716252 EC50 14.0 nM
Oc1ccc2ncn(-c3ccc(F)cc3)c2n1 CHEMBL3716628 EC50 14.0 nM
Nc1nc2ccc(O)nc2n1-c1ccccc1 CHEMBL3717589 EC50 14.0 nM
Oc1ccc2nc(-c3ccccc3)n(-c3ccccc3)c2n1 CHEMBL3716180 EC50 14.0 nM
CCCc1nc2ccc(O)nc2n1-c1ccccc1 CHEMBL3715077 EC50 14.0 nM
Cc1nc2ccc(O)nc2n1-c1ccccc1 CHEMBL3719178 EC50 14.0 nM
Oc1ccc2ncn(-c3ccc4c(c3)CCC4)c2n1 CHEMBL3715949 EC50 14.0 nM
Oc1ccc2ncn(-c3ccc(Cc4ccccc4)cc3)c2n1 CHEMBL3717820 EC50 14.0 nM
Oc1ccc2ncn(-c3ccc4c(c3)OCO4)c2n1 CHEMBL3715155 EC50 14.0 nM
Oc1ccc2ncn(-c3cccc(Cl)c3)c2n1 CHEMBL3717604 EC50 14.0 nM
Oc1ccc2ncn(-c3ccccc3)c2n1 CHEMBL3718619 EC50 14.0 nM
Oc1ccc2ncn(-c3cccc(F)c3C(F)(F)F)c2n1 CHEMBL3717464 EC50 14.0 nM
Cc1nc2ccc(O)nc2n1-c1ccccc1Cl CHEMBL3718342 EC50 14.0 nM
Nc1nc2ccc(O)nc2n1-c1ccccc1Cl CHEMBL3718998 EC50 14.0 nM
Cc1nc2ccc(O)nc2n1C12CC3CC(CC(C3)C1)C2 CHEMBL3718804 EC50 14.0 nM
Nc1nc2ccc(O)nc2n1C12CC3CC(CC(C3)C1)C2 CHEMBL3715572 EC50 14.0 nM
Cc1nc2ccc(O)nc2n1-c1ccccc1F CHEMBL3716997 EC50 14.0 nM
Oc1ccc2ncn(C3CCCCCC3(F)F)c2n1 CHEMBL3716370 EC50 14.0 nM
CC1CCCCC1n1cnc2ccc(O)nc21 CHEMBL3718877 EC50 14.0 nM
Oc1ccc2nc(C3CC3)n(-c3ccccc3Cl)c2n1 CHEMBL3714879 EC50 14.0 nM
Oc1ccc2ncn(-c3ccccc3SC(F)(F)F)c2n1 CHEMBL3719017 EC50 14.0 nM
Cc1nc2ccc(O)nc2n1-c1ccccc1SC(F)(F)F CHEMBL3715889 EC50 14.0 nM
Nc1nc2ccc(O)nc2n1-c1ccccc1SC(F)(F)F CHEMBL3717447 EC50 14.0 nM
Oc1ccc2nc(C3CC3)n(-c3ccccc3OC(F)(F)F)c2n1 CHEMBL3716607 EC50 14.0 nM
Oc1ccc2nc(Cl)n(-c3ccccc3OC(F)(F)F)c2n1 CHEMBL3715916 EC50 14.0 nM
Cc1nc2ccc(O)nc2n1C1CCCCC1 CHEMBL3716253 EC50 14.0 nM
Cc1nc2ccc(O)nc2n1-c1ccccc1Br CHEMBL3715174 EC50 14.0 nM
Oc1ccc2nc(Cl)n(-c3ccccc3Br)c2n1 CHEMBL3719152 EC50 14.0 nM
Oc1ccc2nc(Br)n(-c3ccccc3Br)c2n1 CHEMBL3714960 EC50 14.0 nM
Oc1ccc2nc(Cl)n(-c3ccccc3C(F)(F)F)c2n1 CHEMBL3717818 EC50 14.0 nM
Oc1ccc2nc(Cl)n(-c3ccccc3SC(F)(F)F)c2n1 CHEMBL3715927 EC50 14.0 nM
Cc1ccccc1-n1c(Cl)nc2ccc(O)nc21 CHEMBL3718055 EC50 14.0 nM
Cc1ccccc1-n1c(Br)nc2ccc(O)nc21 CHEMBL3719204 EC50 14.0 nM
Oc1ccc2nc(Cl)n(C3CC4CCC3C4)c2n1 CHEMBL3718632 EC50 14.0 nM
CC1(n2cnc3ccc(O)nc32)CCCCC1 CHEMBL3715620 EC50 14.0 nM
CC1CCCCC1n1c(Cl)nc2ccc(O)nc21 CHEMBL3715601 EC50 14.0 nM
CCC1(n2c(C)nc3ccc(O)nc32)CCCCC1 CHEMBL3716678 EC50 14.0 nM
Cc1nc2ccc(O)nc2n1C1(C)CCCCC1 CHEMBL3715818 EC50 14.0 nM
CS(=O)(=O)Oc1ccc2nc(O)n(C3CCCCC3)c2n1 CHEMBL3718427 EC50 14.0 nM
CS(=O)(=O)Oc1ccc2nc(O)n(-c3ccccc3Br)c2n1 CHEMBL3716136 EC50 14.0 nM
CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(CN4CCN(C)CC4)cc3s2)cc1-n1cccn1 CHEMBL4641219 EC50 19.0 nM
CCOc1cc(Cl)c(-c2ccc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1 CHEMBL4649089 EC50 21.0 nM
CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(CN4CCN(C)CC4)cc3s2)cc1-n1cccc1 CHEMBL4640189 EC50 22.0 nM
CCOc1cc(Cl)c(-c2ccc(-c3nc4c(s3)CN(C(=O)CO)CC4)c(=O)[nH]2)cc1N1CCOCC1 CHEMBL4635089 EC50 22.0 nM
CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)cc1-n1cccn1 CHEMBL4641579 EC50 23.0 nM
Oc1ccc2ncn(C34CC5CC(CC(C5)C3)C4)c2n1 CHEMBL3716171 EC50 30.34 nM
CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(CN4CCN(C)CC4)cc3s2)cc1N1CCO[C@H](C)C1 CHEMBL4649373 EC50 32.0 nM
CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@@H](C)O[C@@H](C)C1 CHEMBL4636832 EC50 54.0 nM
CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(CN4CCN(C)CC4)cc3s2)cc1N1CCOCC1 CHEMBL4632411 EC50 74.0 nM
CCOc1cc(Cl)c(-c2ccc(-c3nc4c(s3)CN(C(=O)COC)CC4)c(=O)[nH]2)cc1N1CCOCC1 CHEMBL4638263 EC50 75.0 nM
Oc1ccc2nc(Cl)n(C3CCCCC3)c2n1 CHEMBL3715375 EC50 75.34 nM
Oc1ccc2nc(Cl)n(-c3ccccc3C3CC3)c2n1 CHEMBL3719273 EC50 81.47 nM
CCOc1cc(Cl)c(C(=O)NC(=O)Nc2ncc(-c3ccccc3)s2)cc1N1CCOCC1 CHEMBL4639430 EC50 103.0 nM
CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(OC4CCN(C)CC4)cc3s2)cc1N1CCOCC1 CHEMBL4646005 EC50 110.0 nM
CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3c(s2)CCCC3)cc1N1CCOCC1 CHEMBL4239086 EC50 120.0 nM
CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1CCO[C@H](C)C1 CHEMBL4649741 EC50 160.0 nM
CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)cc1N1CCOCC1 CHEMBL4634029 EC50 166.0 nM
Oc1ccc2ncn(-c3ccc(Cl)cc3C(F)(F)F)c2n1 CHEMBL3718634 EC50 230.0 nM
CCOc1cc(Cl)c(-c2ncc(-c3nc4ccc(S(=O)(=O)C5CCN(C)CC5)cc4s3)c(=O)[nH]2)cc1N1CCOCC1 CHEMBL4645314 EC50 240.0 nM
CCOc1cc(Cl)c(C(=O)NC(=O)Nc2cc3ccccc3s2)cc1N1CCOCC1 CHEMBL4641428 EC50 260.0 nM
CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@@H](C)C1 CHEMBL4641503 EC50 270.0 nM
CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccccc3s2)cc1N1CCOCC1 CHEMBL4636565 EC50 299.0 nM
CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(CN4CCN(C)CC4)cc3s2)cc1-c1ccn[nH]1 CHEMBL4635725 EC50 360.0 nM
CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(CN4CCN(C)CC4)cc3s2)cc1N1CCOCC1 CHEMBL4642179 EC50 410.0 nM
CCOc1cc(Cl)c(-c2ncc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1 CHEMBL4644587 EC50 490.0 nM
CCOc1ccc(C(=O)NC(=O)Nc2nc3ccc(CN4CCN(C)CC4)cc3s2)c(Cl)c1 CHEMBL4636849 EC50 560.0 nM
CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1CCOCC1 CHEMBL4633635 EC50 600.0 nM
CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3c(s2)CN(C(C)=O)CC3)cc1N1CCOCC1 CHEMBL4638731 EC50 719.0 nM
CCOc1ccc(C(=O)NC(=O)Nc2nc3ccc(CN4CCN(C)CC4)cc3s2)cc1N1CCOCC1 CHEMBL4641372 EC50 740.0 nM
CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)cc1N1CCOCC1 CHEMBL4638676 EC50 740.0 nM
CCOc1cc(Cl)c(C(=O)NC(=O)Nc2ncc(C)s2)cc1N1CCOCC1 CHEMBL4633947 EC50 769.0 nM
CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3c(s2)CN(C(=O)CO)CC3)cc1N1CCOCC1 CHEMBL4643496 EC50 895.0 nM