Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1171837 IC50 0.11 nM
Nc1ncnc2c1c(-c1ccc(Cl)c(O)c1)nn2C1CCCC1 CHEMBL1241676 IC50 0.18 nM
CC(C)N1CCN([C@H]2CC[C@H](n3cc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1 CHEMBL4075002 pIC50 0.257 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL5416410 pKi 0.3162 nM
CN1CCN([C@H]2CC[C@H](n3cc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1 CHEMBL45177 IC50 0.4 nM
C=CC(=O)N[C@H]1CC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 CHEMBL3647967 IC50 1.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@H](N[C@@H](CO)C(=O)O)CC1 CHEMBL4208645 IC50 1.8 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 1.9 nM
Cc1cc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)nc(C)n1 CHEMBL364623 IC50 2.0 nM
CC(C)n1nc(-c2ccc(Cl)c(O)c2)c2c(N)ncnc21 CHEMBL1241484 IC50 2.0 nM
COc1cc(-c2nn(C3CCCC3)c3ncnc(N)c23)ccc1N CHEMBL1241581 IC50 2.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)n(C)c34)c3ccccc23)cc1 CHEMBL1090979 IC50 2.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 2.8 nM
CNS(=O)(=O)Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)cc1 CHEMBL3695574 IC50 3.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)s1 CHEMBL3695593 IC50 3.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(-c2ccccc2)n1 CHEMBL1214131 IC50 3.0 nM
COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(C)cc3)c3ccccc23)ccn1 CHEMBL3695569 IC50 3.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(-c2ccc(S(C)(=O)=O)cc2)n1 CHEMBL3695579 IC50 3.0 nM
COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)n(C)c34)c3ccccc23)cc1 CHEMBL3695583 IC50 3.0 nM
Cc1nc2c(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccccc4)c4ccccc34)ccnc2[nH]c1=O CHEMBL1214132 IC50 3.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(-c2ccc(CO)nc2)n1 CHEMBL3695592 IC50 3.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)cc1 CHEMBL1214134 IC50 3.0 nM
C=CC(=O)Nc1ccccc1Nc1nc(Nc2ccc(N3CCN(C)CC3)cc2)ncc1C(=O)Nc1c(C)cccc1Cl CHEMBL4515441 IC50 3.0 nM
Cc1ccc(NC(=O)c2ccc(C)c(C(F)(F)F)c2)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12 CHEMBL4798527 IC50 3.0 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 IC50 3.2 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 3.3 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@H](N2CCN(CCO)CC2)CC1 CHEMBL4095434 pIC50 3.467 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL1873475 IC50 3.7 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@H](NCC(=O)O)CC1 CHEMBL4066401 IC50 3.7 nM
CC(C)n1nc(-c2ccc(Br)c(O)c2)c2c(N)ncnc21 CHEMBL1241578 IC50 4.0 nM
Cc1ccc(-n2nc(C(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)cc1 CHEMBL3695578 IC50 4.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c(Cl)c2Cl)n(-c2ccc(CO)cc2)n1 CHEMBL3695591 IC50 4.0 nM
COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)n(C)c34)c(Cl)c2Cl)cc1 CHEMBL3695586 IC50 4.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(-c2ccc(Cl)c(Cl)c2)n1 CHEMBL3695580 IC50 4.0 nM
CSc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)cc1 CHEMBL3695581 IC50 4.0 nM
Cc1ccc(-n2nc(C3(C)CC3)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)cc1 CHEMBL3695577 IC50 4.0 nM
Nc1ncnc2c1c(-c1cc(O)cc(F)c1)nn2C1CCCC1 CHEMBL1242199 IC50 4.4 nM
Oc1cccc(Nc2ccnc3cc(-c4cccc(CN5CCOCC5)c4)sc23)c1 CHEMBL2336005 IC50 4.4 nM
CC(C)C[C@H](N[C@H]1CC[C@H](n2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1)C(=O)O CHEMBL4093003 IC50 4.4 nM
Nc1ncnc2c1c(-c1ccc(F)c(O)c1)nn2C1CCCC1 CHEMBL1242568 IC50 4.5 nM
CC(C)(C)n1nc(-c2ccc(Cl)cc2)c2c(N)ncnc21 CHEMBL406845 IC50 5.0 nM
Nc1ncnc2c1c(-c1ccc3cc[nH]c3c1)nn2C1CCCC1 CHEMBL1242664 IC50 5.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)c(C)nc34)c3ccccc23)cc1 CHEMBL1214135 IC50 5.0 nM
COc1cc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)ccc1CO CHEMBL3695590 IC50 5.0 nM
CCn1c(=O)[nH]c2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccc(OC)cc4)c4ccccc34)c21 CHEMBL3695584 IC50 5.0 nM
COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)n(C)c34)c3ccccc23)cn1 CHEMBL3695572 IC50 5.0 nM
COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)cc1 CHEMBL3695573 IC50 5.0 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 5.012 nM
Cc1ccc(-c2nn(C(C)C)c3ncnc(N)c23)cc1O CHEMBL1242026 IC50 5.1 nM
Nc1ncnc2c1c(-c1ccc3[nH]ccc3c1)nn2C1CCCC1 CHEMBL1242295 IC50 5.4 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@@H](N[C@H]2CCOC2=O)CC1 CHEMBL4207885 IC50 5.4 nM
CC1CCC(n2nc(-c3ccc(F)c(O)c3)c3c(N)ncnc32)C1 CHEMBL1242656 IC50 5.7 nM
Nc1ncnc2c1c(-c1ccc(Cl)c(O)c1)nn2C1CCC1 CHEMBL1241580 IC50 5.8 nM
C=CC(=O)N1CCC[C@H](n2c(=O)n(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL3991931 Kd apparent 6.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@H](N[C@H](CO)C(=O)O)CC1 CHEMBL4215201 IC50 6.3 nM
C[C@H](N[C@H]1CC[C@H](n2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1)C(=O)O CHEMBL4206460 IC50 6.9 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)c3ncccc23)n(-c2ccccc2)n1 CHEMBL3695570 IC50 7.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@H](N[C@@H](Cc2ccc(O)cc2)C(=O)O)CC1 CHEMBL4209781 IC50 7.4 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@H](N[C@@H](Cc2ccccc2)C(=O)O)CC1 CHEMBL4216163 IC50 7.5 nM
NC(=O)CN[C@H]1CC[C@H](n2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 CHEMBL4087733 pIC50 7.586 nM
CN1CCN(c2ccc(-c3cnn4c(N)c(-c5cccc(O)c5)cnc34)cc2)CC1 CHEMBL1083023 IC50 8.0 nM
Nc1ncnc2c1c(-c1cnc3[nH]ccc3c1)nn2C1CCCC1 CHEMBL1081312 IC50 8.0 nM
Nc1ncnc2c1c(-c1ccc(Cl)c(O)c1)nn2[C@@H]1CCOC1 CHEMBL1241768 IC50 8.0 nM
COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)n(C(C)C)c34)c3ccccc23)cc1 CHEMBL3695585 IC50 8.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Nc4ccccc4)n3)c3ccccc23)cc1 CHEMBL3701217 Kd 8.0 nM
Nc1ncnc2c1c(-c1ccc(Cl)c(O)c1)nn2[C@H]1CCOC1 CHEMBL1241678 IC50 8.8 nM
Nc1ncnc2c1c(-c1ccc(Br)c(O)c1)nn2C1CCC1 CHEMBL1242287 IC50 8.9 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@H](NCc2ccncc2)CC1 CHEMBL4071932 pIC50 8.913 nM
CCN1CCN(Cc2ccc(C(=O)Nc3ccc(C)c(Nc4nc5ccccc5n4-c4cc(N)ncn4)c3)cc2Cl)CC1 CHEMBL1076433 IC50 9.0 nM
CC(C)n1nc(-c2ccc3c(ccn3C(=O)OC(C)(C)C)c2)c2c(N)ncnc21 CHEMBL1242852 IC50 9.0 nM
Cc1ccc(-n2nc(C3CC3)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)cc1 CHEMBL3695576 IC50 9.0 nM
Cc1ccc(C(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1C#Cc1cc(-c2cnn(C)c2)cnc1N CHEMBL4862806 IC50 9.0 nM
CC(C)n1nc(-c2ccc(F)c(O)c2)c2c(N)ncnc21 CHEMBL1242377 IC50 9.2 nM
CC(C)n1nc(-c2cc(O)cc(Br)c2)c2c(N)ncnc21 CHEMBL1242285 IC50 10.0 nM
COc1ccc(-c2nn(C3CCC(C)C3)c3ncnc(N)c23)cc1O CHEMBL1242202 IC50 10.0 nM
CC(C)n1nc(-c2cnc3[nH]ccc3c2)c2c(N)ncnc21 CHEMBL1242293 IC50 10.0 nM
COc1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=N\OCC(O)CO)C(=O)N2 CHEMBL4065365 IC50 10.7 nM
Cc1ccc(NC(=O)c2cc(CN3CCN(C)CC3)n(C(C)(C)C)n2)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 CHEMBL1075628 IC50 11.0 nM
Nc1ncnc2c1c(-c1ccc(F)c(O)c1)nn2C1CCC1 CHEMBL1242566 IC50 11.0 nM
CCOc1cc(N2CCN(C)CC2)ccc1Nc1ncc2cc(-c3cccc(NC(=O)c4cccc(C(F)(F)F)c4)c3)c(=O)n(C[C@H]3CCCO3)c2n1 CHEMBL5415503 Kd 11.0 nM
Nc1ncnc2c1c(-c1ccc(Br)c(O)c1)nn2C1CCCC1 CHEMBL1242376 IC50 12.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@@H](NCC(=O)O)CC1 CHEMBL4202763 IC50 12.0 nM
Nc1ccc(-c2nn(C3CCCC3)c3ncnc(N)c23)cc1O CHEMBL1241487 IC50 13.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@@H](N[C@H](Cc2ccc(O)cc2)C(=O)O)CC1 CHEMBL4218162 IC50 13.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@H](N[C@H]2CCNC2=O)CC1 CHEMBL4061078 pIC50 13.49 nM
CN1CCN(c2ccc(-c3cnn4c(N)c(-c5ccc(NC(=O)CCC6CCCC6)cc5)cnc34)cc2)CC1 CHEMBL1083001 IC50 14.0 nM
CC(C)n1nc(-c2ccc3[nH]ccc3c2)c2c(N)ncnc21 CHEMBL1242294 IC50 15.0 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 15.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@H](NCCC(=O)O)CC1 CHEMBL4203665 IC50 15.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@H](N[C@H](Cc2ccc(O)cc2)C(=O)O)CC1 CHEMBL4213227 IC50 15.0 nM
CC1(C)CC(NC(=O)c2cccc(-c3cc4nccc(Nc5cccc(O)c5)n4n3)c2)CC(C)(C)N1[O] CHEMBL1163016 IC50 16.0 nM
CCN1CCN(c2cc(C(=O)Nc3ccc(C)c(Nc4nc5ccccc5n4-c4cc(N)ncn4)c3)cc(C(F)(F)F)c2)CC1 CHEMBL1076437 IC50 16.0 nM
COc1ccc(-c2nn(C(C)C)c3ncnc(N)c23)cc1O CHEMBL1242114 IC50 18.0 nM
COc1ccc(-c2nn(C3CCCC3)c3ncnc(N)c23)cc1O CHEMBL1242201 IC50 18.0 nM
CC(C)n1nc(-c2ccc3cc[nH]c3c2)c2c(N)ncnc21 CHEMBL1242574 IC50 18.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(-c2ccc(O)cc2)n1 CHEMBL3695588 IC50 18.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@@H](N[C@H](Cc2ccccc2)C(=O)O)CC1 CHEMBL4210294 IC50 18.0 nM
CCC(C)n1nc(-c2ccc(C)c(O)c2)c2c(N)ncnc21 CHEMBL1242109 IC50 19.0 nM
Cc1ccc(NC(=O)c2cc(N3CCN(C)CC3)cc(C(F)(F)F)c2)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 CHEMBL1076436 IC50 20.0 nM
Nc1ncnc2c1c(-c1ccc(Cl)c(O)c1)nn2[C@@H]1CCNC1 CHEMBL1241677 IC50 20.0 nM
CC(C)n1nc(-c2ccc3cc(O)ccc3c2)c2c(N)ncnc21 CHEMBL1242662 IC50 20.0 nM
CN1CCN(c2ccc(-c3cnn4c(N)c(-c5ccc(NC(=O)NCC6CCCCC6)cc5)cnc34)cc2)CC1 CHEMBL1084234 IC50 21.0 nM
Nc1ncnc2c1c(-c1ccc(F)c(O)c1)nn2[C@H]1CCOC1 CHEMBL1242748 IC50 21.0 nM
COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCc3ccnc4[nH]c(=O)cnc34)c3ccccc23)cc1 CHEMBL3695594 IC50 22.0 nM
COC(=O)c1cc2cc(NCc3cc(NC(=O)c4cc(-n5cnc(C)c5)cc(C(F)(F)F)c4)ccc3C)cnc2[nH]1 CHEMBL3808884 IC50 22.0 nM
CC(C)n1nc(-c2cccc(O)c2)c2c(N)ncnc21 CHEMBL1230790 IC50 23.0 nM
Cc1cc(O)ccc1-c1nn(C(C)C)c2ncnc(N)c12 CHEMBL1242024 IC50 23.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@@H](N[C@H](CO)C(=O)O)CC1 CHEMBL4203527 IC50 23.0 nM
Cn1nc(-c2ccc(Br)c(O)c2)c2c(N)ncnc21 CHEMBL1241299 IC50 24.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(-c2ccc(CO)cc2)n1 CHEMBL3695589 IC50 24.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@H](N[C@H](Cc2ccccc2)C(=O)O)CC1 CHEMBL4205400 IC50 24.0 nM
Nc1ncnc2c1c(-c1ccc(F)c(O)c1)nn2[C@H]1CCNC1 CHEMBL1242657 IC50 25.0 nM
Cc1c(Nc2c(C#N)cnc3sc(/C=C/C(=O)N4CCCC4)cc23)ccc2[nH]ccc12 CHEMBL477817 IC50 26.0 nM
CC(C)n1nc(-c2ccc(O)c(F)c2)c2c(N)ncnc21 CHEMBL1241945 IC50 26.0 nM
COC(=O)Nc1cc(CCOc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(C)cc3)c3ccccc23)ccn1 CHEMBL3781532 IC50 26.0 nM
CNC(=O)Nc1cc(CCOc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(C)cc3)c3ccccc23)ccn1 CHEMBL3781687 IC50 26.0 nM
Cc1ccc(NC(=O)c2cc(OC3CCN(C)CC3)cc(C(F)(F)F)c2)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 CHEMBL1076432 IC50 27.0 nM
CC(C)C[C@@H](N[C@H]1CC[C@H](n2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1)C(=O)O CHEMBL4209498 IC50 27.0 nM
Nc1ncnc2c1c(-c1cccc(O)c1F)nn2C1CCCC1 CHEMBL1242111 IC50 28.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@H](N[C@H]2CCOC2=O)CC1 CHEMBL4202997 IC50 28.0 nM
C=CC(=O)N1CCC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3C)c3c(N)ncnc32)C1 CHEMBL5271284 IC50 29.5 nM
Nc1ncnc2c1c(-c1ccc(F)c(O)c1)nn2C1CCCCCC1 CHEMBL1242750 IC50 30.0 nM
CC(C)n1nc(-c2ccc3cn[nH]c3c2)c2c(N)ncnc21 CHEMBL1242477 IC50 30.0 nM
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 CHEMBL4569508 IC50 30.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1nc2ccccc2n1-c1cc(NCCCN2CCN(C)CC2)ncn1 CHEMBL1076478 IC50 31.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2C1CCOCC1 CHEMBL296103 IC50 31.0 nM
C[C@H](CN)n1nc(-c2ccc(Cl)c(O)c2)c2c(N)ncnc21 CHEMBL1241579 IC50 33.0 nM
Nc1ncnc2c1c(-c1ccc3[nH]ncc3c1)nn2C1CCCC1 CHEMBL1242475 IC50 33.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2C[C@H]1CCCN1C[C@@H]1CO1 CHEMBL4525187 IC50 33.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1 CHEMBL4550702 IC50 33.0 nM
COCOc1cc(-c2nn(C(C)C)c3ncnc(N)c23)ccc1Br CHEMBL1242286 IC50 34.0 nM
CC(C)n1nc(-c2ccc3c(N)n[nH]c3c2)c2c(N)ncnc21 CHEMBL1242476 IC50 35.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ncnc4[nH]c(=O)[nH]c34)c3ccccc23)cc1 CHEMBL3695587 IC50 36.0 nM
C[C@@H](N[C@H]1CC[C@H](n2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1)C(=O)O CHEMBL4212500 IC50 36.0 nM
C[C@@H](N[C@H]1CC[C@@H](n2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1)C(=O)O CHEMBL4205815 IC50 36.0 nM
CN1CCN(c2cccc(-c3cnn4c(N)c(-c5ccc(NC(=O)CCC6CCCC6)cc5)cnc34)c2)CC1 CHEMBL1085316 IC50 37.0 nM
COc1cc(-c2nn(C(C)C)c3ncnc(N)c23)ccc1F CHEMBL1241483 IC50 37.0 nM
COc1cc(-c2nn(C(C)C)c3ncnc(N)c23)ccc1N CHEMBL1241485 IC50 37.0 nM
Nc1ncnc2c1c(-c1ccc3cn[nH]c3c1)nn2C1CCCC1 CHEMBL1242572 IC50 37.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@@H](N[C@@H](Cc2ccc(O)cc2)C(=O)O)CC1 CHEMBL4214689 IC50 39.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@@H](N[C@@H](CO)C(=O)O)CC1 CHEMBL4203767 IC50 40.0 nM
Nc1ncnc2c1c(-c1ccc(F)c(O)c1)nn2C1CNC1 CHEMBL1242567 IC50 42.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 CHEMBL1079945 IC50 43.0 nM
CCN(CC)CCNc1cc(Nc2cc(O)ccc2C)nc(-n2cnc3ccccc32)n1 CHEMBL434369 IC50 46.0 nM
Cc1ccc(NC(=O)c2ccncc2C(C)(C)C)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 CHEMBL1080475 IC50 46.0 nM
CC(C)n1nc(-c2ccc(N)c(O)c2)c2c(N)ncnc21 CHEMBL1242848 IC50 46.0 nM
CC(C)n1nc(-c2ccc(O)cc2)c2c(N)ncnc21 CHEMBL1241241 IC50 47.0 nM
CC(C)n1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc21 CHEMBL1242198 IC50 47.0 nM
COCC(=O)Nc1cc(COc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(C)cc3)c3ccccc23)ccn1 CHEMBL3695568 IC50 47.0 nM
CCN(CC)CCOc1ccc(Nc2ncc3c(n2)N2CCC(=O)N2C(c2c(Cl)cccc2Cl)=C3)cc1 CHEMBL379517 IC50 48.0 nM
CC(C)(C)OC(=O)n1ccc2cc(-c3nn(C4CCCC4)c4ncnc(N)c34)ccc21 CHEMBL1242853 IC50 48.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1nc2ccccc2n1-c1cc(NCCCC2COCCN2)ncn1 CHEMBL1076471 IC50 49.0 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 50.12 nM
Nc1ncnc2c1c(-c1ccc(F)c(O)c1)nn2[C@@H]1CCOC1 CHEMBL1242749 IC50 51.0 nM
CC(=O)Nc1cc(COc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(C)cc3)c3ccccc23)ccn1 CHEMBL3781102 IC50 51.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@H](N2CCC[C@H]2C(=O)O)CC1 CHEMBL4207351 IC50 52.0 nM
CC(C)n1nc(-c2ccc3[nH]ncc3c2)c2c(N)ncnc21 CHEMBL1242386 IC50 53.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc2ccccc2n1-c1ncnc(NCCCN2CCN(C)CC2)n1 CHEMBL1076203 IC50 54.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc2ccccc2n1-c1cc(NCCCCN(C)C)ncn1 CHEMBL1076198 IC50 56.0 nM
Nc1ncnc2c1c(-c1ccc3occc3c1)nn2C1CCCC1 CHEMBL1241491 IC50 56.0 nM
Nc1ncnc2c1c(-c1cccc3[nH]ccc13)nn2C1CCCC1 CHEMBL1242758 IC50 57.0 nM
Cc1ccc(C(=O)Nc2ccc(Cl)cc2Cl)cc1C#Cc1cc(-c2cnn(C)c2)cnc1N CHEMBL4467948 IC50 57.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1nc2ccccc2n1-c1cc(NCCCCN(C)C)ncn1 CHEMBL1076469 IC50 65.0 nM
Cc1ccc(-c2nn(C)c3ncnc(N)c23)cc1O CHEMBL1241271 IC50 65.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@@H](N2CCC[C@@H]2C(=O)O)CC1 CHEMBL4216680 IC50 65.0 nM
Nc1ncnc2c1c(-c1ccc(Cl)c(O)c1)nn2CC1CCNC1 CHEMBL1241770 IC50 67.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1nc2ccccc2n1-c1cc(NCCN2CCN(C)CC2)ncn1 CHEMBL1076477 IC50 69.0 nM
CN1CCN(c2cccc(-c3cnn4c(N)c(-c5ccc(NC(=O)NCC6CCCCC6)cc5)cnc34)c2)CC1 CHEMBL1084028 IC50 70.0 nM
N#CCCCCn1nc(-c2ccc(F)c(O)c2)c2c(N)ncnc21 CHEMBL1242470 IC50 71.0 nM
C[C@H](N[C@H]1CC[C@@H](n2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1)C(=O)O CHEMBL4209614 IC50 73.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@@H](N[C@@H](Cc2ccccc2)C(=O)O)CC1 CHEMBL4204499 IC50 74.0 nM
CC(C)n1nc(-c2cccc(O)c2F)c2c(N)ncnc21 CHEMBL1242110 IC50 76.0 nM
CC(C)n1nc(-c2cc(F)c(O)cc2F)c2c(N)ncnc21 CHEMBL1242028 IC50 76.0 nM
CC(C)n1nc(-c2cc(F)c3cn[nH]c3c2)c2c(N)ncnc21 CHEMBL1242573 IC50 76.0 nM
Cc1ccc(-c2n[nH]c3ncnc(N)c23)cc1O CHEMBL1241270 IC50 78.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@@H](N2CCC[C@H]2C(=O)O)CC1 CHEMBL4212241 IC50 79.0 nM
CCOc1ccc(-c2nn(C3CCCC3)c3ncnc(N)c23)cc1O CHEMBL1242289 IC50 82.0 nM
CC(=O)Nc1cc(CCOc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(C)cc3)c3ccccc23)ccn1 CHEMBL3781430 IC50 82.0 nM
Cc1ccc(NC(=O)c2ccc(C(C)(C)C)s2)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 CHEMBL1086731 IC50 84.0 nM
CN1CCN(c2ccc(-c3cnn4c(N)c(-c5ccc(O)cc5)cnc34)cc2)CC1 CHEMBL1083092 IC50 85.0 nM
Nc1ncnc2c1c(-c1ccc(F)c(O)c1)nn2[C@@H]1CCNC1 CHEMBL1242658 IC50 86.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCCN4)cc2)no1 CHEMBL4793380 IC50 87.0 nM
CN1CCN(c2ccc(-c3cnn4c(N)c(-c5ccc(NC(=O)Oc6ccccc6)cc5)cnc34)cc2)CC1 CHEMBL1085512 IC50 88.0 nM
CC(C)n1nc(-c2ccc3ncccc3c2)c2c(N)ncnc21 CHEMBL1233882 IC50 88.0 nM
Cc1nnc2n1CCN([C@H]1CC[C@H](n3cc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC1)C2 CHEMBL4063307 pIC50 89.13 nM
CC(C)n1nc(-c2ccc3occc3c2)c2c(N)ncnc21 CHEMBL1241490 IC50 91.0 nM
COc1cc(-c2nn(C(C)C)c3ncnc(N)c23)cc(OC)c1OC CHEMBL1242660 IC50 96.0 nM
Cc1cc2cn[nH]c2cc1-c1cccc2c(N)c(C(N)=O)nnc12 CHEMBL3586447 IC50 99.0 nM
COc1cc(-c2nn(C(C)C)c3ncnc(N)c23)ccc1O CHEMBL1242112 IC50 100.0 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 pKi 100.0 nM
CN1CCN(CCOc2cc(OC3CCOCC3)c3c(Nc4c(Cl)ccc5c4OCO5)ncnc3c2)CC1 CHEMBL217092 Kd apparent 100.0 nM
NC(=O)Nc1cc(-c2cccc(F)c2)sc1C(=O)N[C@H]1CCCNC1 CHEMBL2041933 Kd apparent 103.0 nM
CC(C)C[C@H](N[C@H]1CC[C@@H](n2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1)C(=O)O CHEMBL4208669 IC50 105.0 nM
CN1CCN(c2cccc(-c3cnn4c(N)c(-c5ccc(NC(=O)N(C)C6CCCCC6)cc5)cnc34)c2)CC1 CHEMBL1084302 IC50 110.0 nM
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 CHEMBL939 IC50 110.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCc3ccnc(NC(=O)CS(C)(=O)=O)c3)c3ccccc23)cc1 CHEMBL3780832 IC50 110.0 nM
CNC(=O)[C@H](CC(C)C)N[C@H]1CC[C@H](n2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 CHEMBL4085262 IC50 111.0 nM
COc1cc(F)c(-c2nn(C(C)C)c3ncnc(N)c23)cc1F CHEMBL1242027 IC50 113.0 nM
CCn1nc(-c2ccc(OC)c(O)c2)c2c(N)ncnc21 CHEMBL1242113 IC50 115.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 116.0 nM
COc1ccc(-c2nn(C3CCCC3)c3ncnc(N)c23)cc1OC CHEMBL1240553 IC50 117.0 nM
CC(C)CCN[C@H]1CC[C@@H](n2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 CHEMBL4213372 IC50 119.0 nM
Cc1ccc(NC(=O)c2cc(Cl)cc(Cl)c2)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 CHEMBL1079946 IC50 121.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc2ccccc2n1-c1cc(NCCN2CCN(C)CC2)ncn1 CHEMBL1076200 IC50 130.0 nM
COc1ccc(-c2nn(C3CCC3)c3ncnc(N)c23)cc1OC CHEMBL1233881 IC50 130.0 nM
CC(C)n1nc(-c2cc(C3CC3)on2)c2c(N)ncnc21 CHEMBL3753341 IC50 137.0 nM
CO[C@@H](C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 CHEMBL402548 Kd apparent 137.0 nM
CC(C)C[C@@H](N[C@H]1CC[C@@H](n2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1)C(=O)O CHEMBL4212432 IC50 137.0 nM
Cc1ccc(C(=O)Nc2cccc(C(C)(C)C)c2)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 CHEMBL1087128 IC50 139.0 nM
CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 CHEMBL4281823 IC50 142.0 nM
CCS(=O)(=O)c1cccc(-c2cc(C(=O)NC3CCN(C)CC3)c(C)c3[nH]c4ncc(C)cc4c23)c1 CHEMBL3544932 Kd apparent 143.0 nM
Cn1ccc2cc(-c3nn(C4CCCC4)c4ncnc(N)c34)ccc21 CHEMBL1242385 IC50 148.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 150.0 nM
Cc1ccc(C(=O)Nc2cccc(C(C)C)c2)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 CHEMBL1087127 IC50 151.0 nM
CC(C)n1nc(-c2ccc3c(ccn3C)c2)c2c(N)ncnc21 CHEMBL1242384 IC50 153.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 pKi 158.49 nM
O=C1CCN2c3nc(Nc4ccc(N5CCOCC5)cc4)ncc3C=C(c3c(Cl)cccc3Cl)N12 CHEMBL213745 IC50 160.0 nM
C[C@H](CN)n1nc(-c2ccc(F)c(O)c2)c2c(N)ncnc21 CHEMBL1242378 IC50 161.0 nM
COCC(=O)Nc1cc(CCOc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(C)cc3)c3ccccc23)ccn1 CHEMBL3780154 IC50 164.0 nM
CN1CCN(c2cccc(-c3cnn4c(N)c(-c5ccc(NC(=O)Nc6ccccc6Cl)cc5)cnc34)c2)CC1 CHEMBL1085061 IC50 172.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc4ncccc4c3)c(F)c2)ccn1 CHEMBL1738757 Kd apparent 176.0 nM
CN1CCN(c2ccc(-c3cnn4c(N)c(-c5ccc(NC(=O)N(C)C6CCCCC6)cc5)cnc34)cc2)CC1 CHEMBL1082693 IC50 178.0 nM
COc1cccc(-c2nn(C(C)C)c3ncnc(N)c23)c1 CHEMBL1242029 IC50 180.0 nM
CC(C)COC(=O)Nc1ccc(-c2cnc3c(-c4ccc(N5CCN(C)CC5)cc4)cnn3c2N)cc1 CHEMBL1085511 IC50 181.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCc3ccnc(NC(=O)CN4CCOCC4)c3)c3ccccc23)cc1 CHEMBL3780667 IC50 187.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 IC50 190.0 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 190.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1nc2ccccc2n1-c1cc(NCCO)ncn1 CHEMBL1087638 IC50 192.0 nM
CN1CCN(c2cccc(-c3cnn4c(N)c(-c5ccc(NC(=O)Oc6ccccc6)cc5)cnc34)c2)CC1 CHEMBL1085564 IC50 193.0 nM
C[C@@H](CN)n1nc(-c2ccc(Cl)c(O)c2)c2c(N)ncnc21 CHEMBL1240544 IC50 194.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCc3ccnc(NC(=O)CN(C)C)c3)c3ccccc23)cc1 CHEMBL3781244 IC50 197.0 nM
C=CS(=O)(=O)N1CCC[C@@H]1Cn1cc(-c2ccc3c(c2)OCO3)c2c(N)ncnc21 CHEMBL4095253 IC50 199.4 nM
Cc1cccc(Nc2nc(NC3CCCCC3N)cnc2C(N)=O)c1 CHEMBL1974328 pKi 199.53 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc32)c1C CHEMBL1990885 pKi 199.53 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2[C@H]1CC[C@H](N2CCC[C@@H]2C(=O)O)CC1 CHEMBL4211710 IC50 200.0 nM
CSCC(=O)Nc1cc(COc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(C)cc3)c3ccccc23)ccn1 CHEMBL3781245 IC50 208.0 nM
CC(C)C[C@H](N[C@H]1CC[C@H](n2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1)C(N)=O CHEMBL4065334 pIC50 208.93 nM
CN1CCN(c2ccc(-c3cnn4c(N)c(-c5ccc(NC(=O)Nc6ccccc6Cl)cc5)cnc34)cc2)CC1 CHEMBL1084233 IC50 215.0 nM
Cn1nc(-c2ccc3cc[nH]c3c2)c2c(N)ncnc21 CHEMBL1240566 IC50 220.0 nM
CC(C)CCN[C@H]1CC[C@H](n2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 CHEMBL4207785 IC50 226.0 nM
Nc1ncnc2c1c(-c1ccc(Cl)c(O)c1)nn2CCC1CCCNC1 CHEMBL1241943 IC50 244.0 nM
Cc1cccc(C(=O)Nc2ccc(C)c(Nc3nc4ccccc4n3-c3cc(N)ncn3)c2)c1 CHEMBL1080299 IC50 245.0 nM
CC(C)n1nc(-c2ccc3nc[nH]c(=O)c3c2)c2c(N)ncnc21 CHEMBL1241776 IC50 248.0 nM
Cc1c2cc(cc1C(=O)Nc1cc(CN3CCN(C)CC3)cc(C3CC3)c1)OCCCCCCCNC(=O)c1ccc3ncc(n3n1)C#C2 CHEMBL5423601 IC50 252.8 nM
CN1CCN(c2ccc(-c3cnn4c(N)c(-c5ccc(NC(=O)c6ccc(C(F)(F)F)cc6)cc5)cnc34)cc2)CC1 CHEMBL1085733 IC50 256.0 nM
N#CCCCn1nc(-c2ccc(F)c(O)c2)c2c(N)ncnc21 CHEMBL1242469 IC50 258.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc2ccccc2n1-c1cc(NCCCN2CCN(C)CC2)ncn1 CHEMBL1076201 IC50 260.0 nM
Cn1nc(-c2ccc3ccccc3c2)c2c(N)ncnc21 CHEMBL1234815 IC50 260.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 263.0 nM
CC(C)COC(=O)Nc1ccc(-c2cnc3c(-c4cccc(N5CCN(C(=O)CN)CC5)c4)cnn3c2N)cc1 CHEMBL1082404 IC50 270.0 nM
CC(C)n1nc(-c2ccc3c(C=O)c[nH]c3c2)c2c(N)ncnc21 CHEMBL1242666 IC50 270.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 270.0 nM
CCc1cc(Nc2nccc(-c3c(-c4ccc(OC)c(C(=O)Nc5c(F)cccc5F)c4)nc4ccccn34)n2)c(OC)cc1N1CCC(N2CCN(S(C)(=O)=O)CC2)CC1 CHEMBL466397 IC50 275.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 280.0 nM
COCCNCc1ccc(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccc(F)cc5)cc4F)c3s2)nc1 CHEMBL3989914 Kd apparent 283.0 nM
CCOc1ccc(-c2nn(C3CCCC3)c3ncnc(N)c23)cc1OC CHEMBL1240554 IC50 285.0 nM
CN1CCN(c2cccc(-c3cnn4c(N)c(-c5ccc(NC(=O)c6ccc(C(F)(F)F)cc6)cc5)cnc34)c2)CC1 CHEMBL1085240 IC50 295.0 nM
Cc1cccc(Cl)c1NC(=O)c1cnc(NC(=O)C2CC2)s1 CHEMBL131577 IC50 310.0 nM
CC(C)COC(=O)Nc1ccc(-c2cnc3c(-c4cccc(N5CCNCC5)c4)cnn3c2N)cc1 CHEMBL1083644 IC50 310.0 nM
COc1ccc(-c2nn([C@@H]3CCNC3)c3ncnc(N)c23)cc1O CHEMBL1242288 IC50 311.0 nM
Nc1ncnc2c1c(-c1cnc3ccccc3c1)nn2C1CCCC1 CHEMBL1242755 IC50 326.0 nM
Nc1ncnc2c1c(-c1ccc(Cl)c(O)c1)nn2CC1CCCN1 CHEMBL1241769 IC50 328.0 nM
CN1CCN(c2cccc(-c3cnn4c(N)c(-c5ccc(O)cc5)cnc34)c2)CC1 CHEMBL1083091 IC50 342.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1nc2ccccc2n1-c1cc(NCCCCN)ncn1 CHEMBL1076466 IC50 345.0 nM
COCCN1CCN(c2ccc(-c3cnn4c(N)c(-c5ccc(NC(=O)OCC(C)C)cc5)cnc34)cc2)CC1 CHEMBL1082958 IC50 349.0 nM
COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 CHEMBL24828 Kd 360.0 nM
CCN(CC)CCNc1cc(-n2c(Nc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)nc3ccccc32)ncn1 CHEMBL1076468 IC50 378.0 nM
COc1ccc(-c2nn(C(C)C)c3ncnc(N)c23)cc1 CHEMBL1242847 IC50 380.0 nM
Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1 CHEMBL255863 Kd 390.0 nM
Oc1cc(O)cc(C=Cc2ccc(O)c(O)c2)c1 CHEMBL1972346 pKi 398.11 nM
COCCNc1cc(-n2c(Nc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)nc3ccccc32)ncn1 CHEMBL1076480 IC50 405.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 410.0 nM
Cn1nc(-c2cnc3[nH]ccc3c2)c2c(N)ncnc21 CHEMBL1240565 IC50 420.0 nM
CC(C)n1nc(-c2cnc3ccccc3c2)c2c(N)ncnc21 CHEMBL1242754 IC50 422.0 nM
CCN(CC)CCCCNc1cc(-n2c(Nc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)nc3ccccc32)ncn1 CHEMBL1076470 IC50 430.0 nM
COc1cc(Br)cc(-c2nn(C(C)C)c3ncnc(N)c23)c1 CHEMBL1242200 IC50 436.0 nM
Cn1cc(C2=Nc3cc(NC(=O)C(N)C4CCCCC4)cc4c3C2=CNNC4=O)cn1 CHEMBL3545137 Kd apparent 436.0 nM
COc1ccc(-c2nn(C(C)(C)C)c3ncnc(N)c23)cc1OC CHEMBL1242379 IC50 440.0 nM
COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1 CHEMBL1908396 Kd 440.0 nM
Cc1ccc(NC(=O)c2cc(C3CC3)n[nH]2)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 CHEMBL1086860 IC50 446.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1nc2ccccc2n1-c1cc(N[C@H]2CC[C@H](N)CC2)ncn1 CHEMBL1076473 IC50 450.0 nM
CN1CCN(c2ccc(Nc3ncc4c(n3)N3CCC(=O)N3C(c3cc(O)ccc3Cl)=C4)cc2)CC1 CHEMBL213356 IC50 456.0 nM
Cc1cc(NC(=O)OCC(C)C)ccc1-c1cnc2c(-c3cccc(N4CCN(C)CC4)c3)cnn2c1N CHEMBL1085996 IC50 456.0 nM
COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ncnc4[nH]c(=O)cnc34)c3ccccc23)cc1 CHEMBL3695595 IC50 458.0 nM
Cc1ccc(NC(=O)c2cccc(Cl)c2)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 CHEMBL1079422 IC50 475.0 nM
CCN(CC)CCCCNc1cc(-n2c(Nc3cc(C(=O)Nc4cccc(C(F)(F)F)c4)ccc3C)nc3ccccc32)ncn1 CHEMBL1076199 IC50 475.0 nM
CC(=O)Nc1cnccc1CCOc1ccc(NC(=O)Nc2cc(C(C)(C)C)nn2-c2ccc(C)cc2)c2ccccc12 CHEMBL3780488 IC50 482.0 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL180022 Kd 490.0 nM
Nc1ncnc2c1c(-c1ccc(Cl)cc1)nn2-c1cccc(-c2cnnn2CCCCCC(=O)NO)c1 CHEMBL2408778 Ki 504.0 nM
CC(C)n1nc(-c2ccc(CC#N)cc2)c2c(N)ncnc21 CHEMBL1240545 IC50 510.0 nM
CC(C)n1nc(-c2cc(F)c(C=O)c(F)c2)c2c(N)ncnc21 CHEMBL1241861 IC50 516.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1336 IC50 530.0 nM
CCOc1ccc2cc(-c3nn(C)c4ncnc(N)c34)ccc2c1 CHEMBL1242661 IC50 540.0 nM
Nc1ncnc2c1c(-c1ccc3ncccc3c1)nn2C1CCCC1 CHEMBL1241681 IC50 540.0 nM
CN(C)c1ccc(Nc2ncc3c(n2)N2CCC(=O)N2C(c2cc(O)ccc2Cl)=C3)cc1 CHEMBL211852 IC50 546.0 nM
Cc1c(Nc2c(C#N)cncc2/C=C/c2cccc(S(=O)(=O)N3CCN(C)CC3)c2)ccc2[nH]ccc12 CHEMBL1080994 IC50 550.0 nM
CCOc1ccc(-c2nn(C(C)C)c3ncnc(N)c23)cc1OC CHEMBL1242472 IC50 551.0 nM
COc1cc(-c2nn(C(C)C)c3ncnc(N)c23)ccc1NC(C)CO CHEMBL1241486 IC50 567.0 nM
COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1 CHEMBL491473 Kd 590.0 nM
CC(C)COC(=O)Nc1ccc(-c2cnc3c(-c4cccc(N5CCN(C)CC5)c4)cnn3c2N)cc1 CHEMBL1085317 IC50 594.0 nM
Cc1nn(-c2ccccc2)nc1Cn1nc(-c2ccc(F)c(O)c2)c2c(N)ncnc21 CHEMBL1242845 IC50 596.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL574737 Kd apparent 621.0 nM
Nc1ncnc2c1c(-c1cccc(OCc3ccccc3)c1)cn2[C@H]1C[C@H](N2CCC2)C1 CHEMBL551064 Kd apparent 623.0 nM
COc1ccc(-c2n[nH]c3ncnc(N)c23)cc1O CHEMBL1241300 IC50 624.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCc3ccncc3N)c3ccccc23)cc1 CHEMBL3780111 IC50 625.0 nM
O=C(O)c1ccc(Nc2ncc3c(n2)-c2ccc(Cl)cc2C(c2c(F)cccc2F)=NC3)cc1 CHEMBL259084 pKi 630.96 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 664.0 nM
CC(C)COC(=O)Nc1ccc(-c2cnc3c(-c4cccc(N5CCN(S(C)(=O)=O)CC5)c4)cnn3c2N)cc1 CHEMBL1082403 IC50 676.0 nM
CC(C)C[C@H](N[C@H]1CC[C@H](n2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1)C(=O)N(C)C CHEMBL4103186 IC50 686.0 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nc(-c2cccnc2)cs1 CHEMBL1908391 Kd 690.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCc3ccnc(NC(=O)Cc4ccccc4)c3)c3ccccc23)cc1 CHEMBL3781473 IC50 692.0 nM
CC(C)n1nc(-c2ccc(C#N)c(O)c2)c2c(N)ncnc21 CHEMBL1241944 IC50 708.0 nM
COc1cccc(Nc2ncnn3ccc(CN4CC[C@@H](N)[C@H](O)C4)c23)c1 CHEMBL3545396 Kd apparent 712.0 nM
Nc1ncnc2c1c(-c1ccc(F)c(O)c1)nn2Cc1ocnc1-c1ccccc1 CHEMBL1241482 IC50 714.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 720.0 nM
O=C(CCCCCC(=O)N1CCC[C@@H]1c1ccco1)Nc1cccc(Nc2nccc(Nc3cc(C4CC4)[nH]n3)n2)c1 CHEMBL3617738 Ki 730.0 nM
COc1cccc(-c2nn(C(C)C)c3ncnc(N)c23)c1OC CHEMBL1242751 IC50 733.0 nM
COc1ccc(-c2nn(C)c3ncnc(N)c23)cc1O CHEMBL1241301 IC50 794.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1nc2ccccc2n1-c1cc(NCCC2CCCN2)ncn1 CHEMBL1076472 IC50 805.0 nM
COCC(=O)Nc1cc(C(C)Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(C)cc3)c3ccccc23)ccn1 CHEMBL3781982 IC50 807.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCc3ccnc(N)c3)c3ccccc23)cc1 CHEMBL3781587 IC50 829.0 nM
Cc1ccc(NC(=O)c2cc(C(C)(C)C)nn2C)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 CHEMBL1088153 IC50 844.0 nM
CC(C)n1nc(-c2ccc(C=O)c(F)c2)c2c(N)ncnc21 CHEMBL1241860 IC50 855.0 nM
CCOc1ccc(-c2nn(C3CCCCC3)c3ncnc(N)c23)cc1OC CHEMBL1242659 IC50 861.0 nM
Nc1ncnc2c1c(-c1ccc(Cl)c(O)c1)nn2CC1CCNCC1 CHEMBL1241859 IC50 862.0 nM
CC(C)n1nc(-c2ccc3nc(Cl)ccc3c2)c2c(N)ncnc21 CHEMBL1241683 IC50 878.0 nM
CN(C)CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL3745919 GI50 880.0 nM
CC(C)n1nc(-c2ccc3c(c2)CCO3)c2c(N)ncnc21 CHEMBL1241587 IC50 889.0 nM
CCNC(=O)C#Cc1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN(C)C)cc1)c1ccccc1 CHEMBL3699142 Kd apparent 900.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCc3ccncc3)c3ccccc23)cc1 CHEMBL143134 IC50 901.0 nM
Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nc5ccccc5n4-c4cc(N)ncn4)c3)cc(C(F)(F)F)c2)cn1 CHEMBL1076193 IC50 904.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1nc2ccccc2n1-c1cc(NCCc2ccccn2)ncn1 CHEMBL1076475 IC50 917.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(-c2ccc(Cl)cc2)n1 CHEMBL3695575 IC50 918.0 nM
COc1ccc(-c2nn(C[C@H](C)CO)c3ncnc(N)c23)cc1OC CHEMBL1242380 IC50 920.0 nM
CC(C)n1nc(-c2ccc3nccnc3c2)c2c(N)ncnc21 CHEMBL1241774 IC50 946.0 nM
O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1ccccc1 CHEMBL2380845 IC50 958.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL1240703 Kd 960.0 nM
CCCC(=O)Nc1cccc(Nc2nccc(Nc3cc(C4CC4)[nH]n3)n2)c1 CHEMBL3617732 Ki 980.0 nM
CNc1nc(Nc2ccc(C)c(N)c2)ncc1C(=O)Nc1cc(NC(=O)c2cccc(C(F)(F)F)c2)ccc1C CHEMBL3780219 GI50 980.0 nM
CC(C)n1nc(-c2ccc(F)c(C#N)c2)c2c(N)ncnc21 CHEMBL1241680 IC50 1000.0 nM
CC(C)n1nc(-c2ccc3c(c2)OCCO3)c2c(N)ncnc21 CHEMBL1241588 IC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM