CC(C)(O)C1Cc2cc3cc(-c4cc(O)cc(O)c4)oc3cc2O1 CHEMBL205924 IC50 0.14 nM
CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)CC(=O)[C@H](C)C=C(C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)C=CC=CC=C1C CHEMBL1328768 Potency 0.6 nM
CC1(C)Oc2cc3oc(-c4cc(O)cc(O)c4)cc3cc2C[C@H]1O CHEMBL561971 IC50 0.65 nM
CC1(C)Oc2cc3oc(-c4cc(O)cc(O)c4)cc3cc2CC1O CHEMBL380456 IC50 0.65 nM
CCCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)C(=O)C[C@@]21C CHEMBL577673 Potency 0.8 nM
C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COC(=O)C(C)(C)C CHEMBL1200877 Potency 0.8 nM
CCCC1O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1 CHEMBL1370 Potency 0.8 nM
CC(=O)OCC(=O)[C@@]12OC(C)(C)O[C@@H]1C[C@H]1[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]12C CHEMBL1501 Potency 1.0 nM
CC(C)(O)[C@H]1Cc2cc3cc(-c4ccc(O)cc4)oc3cc2O1 CHEMBL1795446 IC50 1.0 nM
COc1cc([C@@H]2c3cc4c(cc3[C@@H](Nc3ccc([N+](=O)[O-])cc3)[C@H]3COC(=O)[C@H]23)OCO4)cc(OC)c1O CHEMBL283631 IC50 1.0 nM
CC(=O)OCC(=O)[C@@]12OC3(CCCC3)O[C@@H]1C[C@H]1[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]12C CHEMBL1200732 Potency 1.3 nM
O=C(Nc1cccc(F)c1)N1CC2(CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)C1 CHEMBL1513684 Potency 1.3 nM
CCC[C@@H]1O[C@@H]2C[C@@H]3[C@H]4CCC5=CC(=O)C=C[C@@]5(C)[C@H]4[C@H](O)C[C@@]3(C)[C@@]2(C(=O)CO)O1 CHEMBL1355978 Potency 1.3 nM
C[C@@H]1C[C@H]2[C@H]3C[C@@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@@]2(C)[C@@H]1C(=O)COC(=O)C(C)(C)C CHEMBL1556023 Potency 1.3 nM
CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1 CHEMBL989 Potency 1.3 nM
CCC[C@@H]1O[C@@H]2C[C@@H]3[C@@H]4CCC5=CC(=O)C=C[C@@]5(C)[C@H]4[C@H](O)C[C@@]3(C)[C@@]2(C(=O)CO)O1 CHEMBL1433436 Potency 1.6 nM
CS(=O)(=O)N1CCC2(CC1)CN(c1ccccc1)C2 CHEMBL1473498 Potency 1.6 nM
CC(=O)OCC(=O)[C@@]1(O)CC[C@@H]2[C@H]3CCC4=CC(=O)C=C[C@]4(C)[C@]3(F)[C@@H](O)C[C@@]21C CHEMBL1434739 Potency 2.0 nM
C[C@H](N[C@@H](C)CCc1ccccc1)[C@H](O)c1ccc(O)cc1 CHEMBL1320485 Potency 2.0 nM
COc1cc([C@H]2c3cc4c(cc3[C@@H](O)[C@@H]3COC(=O)[C@H]23)OCO4)cc(OC)c1OC CHEMBL1330659 Potency 2.0 nM
CCOC(=O)O[C@]1(C(=O)COC(=O)CC)CC[C@@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4(C)[C@H]3[C@H](O)C[C@]21C CHEMBL1397466 Potency 2.5 nM
CC(C)(C)NC[C@@H](O)c1ccc(O)c(CO)n1 CHEMBL1589998 Potency 2.5 nM
CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@H](C)C[C@@H]2[C@H]3CCC4=CC(=O)C=C[C@]4(C)[C@]3(Cl)[C@@H](O)C[C@@]21C CHEMBL1356783 Potency 2.5 nM
C[C@]1(c2ccccc2)O[C@@H]2C[C@@H]3[C@@H]4CCC5=CC(=O)C=C[C@@]5(C)[C@]4(F)[C@H](O)C[C@]3(C)[C@@]2(C(=O)CO)O1 CHEMBL1335455 Potency 2.5 nM
Cc1ccc(Cn2nc(-c3nc4ccc(-c5ccc(Cl)cc5)cc4[nH]3)cc2C)cc1 CHEMBL2205734 IC50 3.0 nM
COc1ccc([C@@H](O)[C@@H](C)Oc2ccc([C@@H]3CC[C@H](c4ccc(O[C@H](C)[C@H](O)c5ccc(OC)c(OC)c5)c(OC)c4)C3)cc2OC)cc1OC CHEMBL4538400 IC50 3.0 nM
CC(C)(C)NC[C@H](O)c1ccc(O)c(CO)c1 CHEMBL1002 Potency 3.2 nM
CC(C)(C)NC[C@H](O)c1ccccc1Cl CHEMBL1607062 Potency 3.2 nM
CCCC(=O)O[C@]1(C(=O)COC(C)=O)CC[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C CHEMBL1201749 Potency 4.0 nM
CC(=O)OCC(=O)[C@@]1(OC(C)=O)[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@@]4(C)[C@]3(F)[C@H](O)C[C@@]21C CHEMBL1433593 Potency 4.0 nM
CC(C)(O)C1Cc2cc3cc(-c4ccc(O)cc4)oc3cc2O1 CHEMBL1795435 IC50 4.2 nM
CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](Cl)C[C@@]21C CHEMBL1385514 Potency 5.0 nM
C[C@@H](CCc1ccccc1)NC[C@H](O)c1ccc(O)c(C(N)=O)c1 CHEMBL28140 Potency 5.0 nM
CCCCC(=O)O[C@]1(C(=O)CO)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C CHEMBL1200562 Potency 5.0 nM
C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO CHEMBL1201392 Potency 5.0 nM
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO CHEMBL1766 Potency 5.0 nM
C[C@@H]1C[C@@H]2[C@H]3CCC4=CC(=O)C=C[C@]4(C)[C@]3(F)[C@@H](O)C[C@@]2(C)[C@@]1(O)C(=O)CO CHEMBL1354141 Potency 6.3 nM
CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)CC[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1 CHEMBL1201012 Potency 6.3 nM
CC(=O)OCC(=O)[C@@]12OC(C)(C)O[C@@H]1C[C@H]1[C@H]3C[C@H](F)C4=CC(=O)C=C[C@@]4(C)[C@]3(F)[C@H](O)C[C@@]12C CHEMBL1597239 Potency 6.3 nM
CC(C)(O)[C@H]1Cc2cc3cc(-c4cc(O)cc(O)c4)oc3cc2O1 CHEMBL1795432 IC50 6.76 nM
COc1cccc(-c2cc3cc4c(cc3o2)OC(C(C)(C)O)C4)c1 CHEMBL1795439 IC50 7.0 nM
CC(=O)OCC(=O)[C@@]1(O)[C@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C CHEMBL1530428 Potency 7.9 nM
COC(=O)NC/C=C\c1nc(CC/C=C\C(=O)O[C@H]2C[C@H]3CC(=O)O[C@@H](/C=C\CC(C)C)C[C@@H]4CC[C@H](C)[C@H](C[C@@H](OC)C[C@H](C2)O3)O4)co1 CHEMBL1553635 Potency 7.9 nM
CC(C)(C)NC[C@H](O)c1cc(O)cc(O)c1 CHEMBL356716 Potency 7.9 nM
CC(=O)[C@@]1(O)CC[C@H]2[C@H]3C[C@@H](C)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]21C CHEMBL1475698 Potency 7.9 nM
C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@@]4(C)[C@]3(F)[C@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO CHEMBL1414885 Potency 7.9 nM
CC(=O)OCC(=O)[C@@]1(OC(C)=O)[C@@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C CHEMBL1200545 Potency 10.0 nM
CC(NCCc1ccc(O)cc1)C(O)c1ccc(O)cc1 CHEMBL1367605 Potency 10.0 nM
CC(C)(C)NCC(O)c1cc(O)cc(O)c1 CHEMBL1160544 Potency 10.0 nM
CCCCC[C@H](O)/C=C\[C@@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O CHEMBL1318789 Potency 10.0 nM
CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@H]2C[C@@H]1C[C@H]1NCCc2c1[nH]c1ccc(O)cc21 CHEMBL1369261 Potency 10.0 nM
CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C CHEMBL1200600 Potency 10.0 nM
CCOc1ccc2nc(S(N)(=O)=O)sc2c1 CHEMBL18 Potency 10.0 nM
C[C@@H](Cc1ccc(OCC(=O)[O-])cc1)NC[C@H](O)c1cccc(Cl)c1 CHEMBL1357401 Potency 10.0 nM
COC(=O)c1sc(NC(=O)c2oc3ccccc3c2C)nc1C CHEMBL1304256 Potency 10.0 nM
CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1 CHEMBL1504 Potency 10.0 nM
CC(C)NCC[C@@H](O)c1cc2ccccc2o1 CHEMBL1493388 Potency 10.0 nM
COc1cc(OC)cc(-c2cc3cc4c(cc3o2)OC(C(C)(C)O)C4)c1 CHEMBL1795433 IC50 10.0 nM
CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3c(CN(C)C)c(O)ccc3nc2-1 CHEMBL84 EC50 12.0 nM
CC(C)NC[C@H](O)c1ccc(O)c(O)c1 CHEMBL1160723 Potency 12.6 nM
N[C@H](Cc1ccc2oc3cc(=O)c4ccccc4c-3nc2c1)C(=O)O CHEMBL1410627 Potency 12.6 nM
COc1ccccc1CCn1c(=O)cnc2cncnc21 CHEMBL1357157 Potency 12.6 nM
c1ccc2c(c1)Cc1c(Nc3ccc4c(c3)OCCO4)n[nH]c1-2 CHEMBL2323956 IC50 14.0 nM
CC(C)=NNc1ncnc2[nH]cnc12 CHEMBL1489044 Potency 15.8 nM
CC1(C)O[C@@H]2C[C@H]3[C@H]4C[C@H](F)C5=CC(=O)CC[C@]5(C)[C@@H]4[C@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1 CHEMBL1355879 Potency 15.8 nM
CC(C)NC[C@H](O)c1ccc2ccccc2c1 CHEMBL1160730 Potency 15.8 nM
Nc1ncnc2c([C@@H]3O[C@@H](CO)[C@H](O)[C@@H]3O)nsc12 CHEMBL1338950 Potency 15.8 nM
CNC[C@H](O)c1ccc(OC(=O)C(C)(C)C)c(OC(=O)C(C)(C)C)c1 CHEMBL1516080 Potency 15.8 nM
C[C@@H]1C[C@@H]2[C@H]3CCC4=CC(=O)C=C[C@]4(C)[C@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO CHEMBL1358636 Potency 15.8 nM
C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CCC2=O CHEMBL1405 Potency 15.8 nM
COc1ccc(C[C@@H]2C(=O)N[C@H](C)C(=O)N(C)[C@@H]3Cc4ccc(cc4)Oc4cc(ccc4O)C[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N2C)N(C)C3=O)cc1 CHEMBL1475206 Potency 15.8 nM
COc1cc([C@@H]2c3cc4c(cc3[C@H](O)[C@H]3COC(=O)[C@H]23)OCO4)cc(OC)c1OC CHEMBL61 Potency 15.8 nM
CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@H](C)C[C@@H]2[C@@H]3[C@H]([C@@H](O)C[C@@]21C)[C@]1(C)C=CC(=O)C=C1C[C@@H]3Cl CHEMBL1476383 Potency 20.0 nM
CC(=O)OCC(=O)[C@@]1(O)[C@H](C)C[C@@H]2[C@H]3CCC4=CC(=O)C=C[C@]4(C)[C@]3(F)[C@@H](O)C[C@@]21C CHEMBL1474523 Potency 20.0 nM
C[C@@]12CCC(=O)C=C1CC[C@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@H]1CC[C@@]2(O)C(=O)CO CHEMBL1472865 Potency 20.0 nM
C[C@]12C=CC(=O)C=C1CC[C@@H]1[C@H]3C[C@@H](O)[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@]12F CHEMBL1435692 Potency 20.0 nM
Cn1cc(-c2nc3cnc(Oc4ccccc4)nc3n(C)c2=O)c2ccccc21 CHEMBL1360151 Potency 20.0 nM
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)([O-])O CHEMBL1200637 Potency 20.0 nM
O=C(Nc1nc(NC(=O)c2ccco2)n(-c2ccccc2)n1)c1ccccc1 CHEMBL487356 Potency 20.0 nM
CC(C)(C)C(=O)[C@H]([C@@H](c1ccccc1)N1CCOCC1)N1CCOCC1 CHEMBL1570996 Potency 20.0 nM
COc1ccc([C@@H](O)[C@@H](C)Oc2ccc([C@H]3O[C@H](c4ccc(OC)c(OC)c4)[C@H](C)[C@H]3C)cc2OC)cc1OC CHEMBL3105545 IC50 20.0 nM
COc1ccc([C@@H](O)[C@@H](C)Oc2ccc([C@@H]3CCN(c4ccc(OC)c(OC)c4)C3)cc2OC)cc1OC CHEMBL4434875 IC50 22.8 nM
CN(C)c1ccc(NC(=O)c2noc3ccccc23)cc1 CHEMBL5205360 IC50 24.0 nM
CC(=O)c1ccc(NC(=O)c2noc3ccccc23)cc1 CHEMBL5184354 IC50 24.0 nM
CS(=O)(=O)N1CCC2(CC1)CN(c1ccncc1)C2 CHEMBL1355708 Potency 25.1 nM
CC(C)NC[C@H](O)c1cc(O)cc(O)c1 CHEMBL1160709 Potency 25.1 nM
COc1ccc(C(=O)N2CCC3(CC2)CN(CC(C)C)C3)cc1 CHEMBL1437213 Potency 25.1 nM
COc1ccc(Oc2ncc3nc(-c4ccc(F)cc4)c(=O)n(C4CC4)c3n2)cc1 CHEMBL1514416 Potency 25.1 nM
CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C CHEMBL1152 Potency 25.1 nM
Cc1noc(C)c1C(=O)N1CCC2(CCN(Cc3ccc(C#N)cc3)CC2)CC1 CHEMBL1608984 Potency 25.1 nM
COc1ccc(C(=O)N/N=C2/C(=O)c3c(C)cc(C)cc3CC2(C)C)cc1 CHEMBL1515131 Potency 25.1 nM
O=C1O[C@@H]([C@H](O)[C@H](O)[C@H](O)CO)[C@@H](O)[C@@H]1O CHEMBL1453641 Potency 25.1 nM
C[C@]12C=CC(=O)C=C1CC[C@H]1[C@@H]3C[C@@H](O)[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@]12F CHEMBL1451 Potency 31.6 nM
CCC(=O)[C@@]1(C)[C@H](C)C[C@@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4(C)[C@H]3[C@H](O)C[C@]21C CHEMBL1591581 Potency 31.6 nM
C[C@H]1C[C@@H]2[C@H]3CCC4=CC(=O)C=C[C@@]4(C)[C@]3(Cl)[C@@H](Cl)C[C@]2(C)[C@]1(O)C(=O)COP(=O)(O)O CHEMBL1474922 Potency 31.6 nM
O=C(O)CSCC(=O)O CHEMBL1570500 Potency 31.6 nM
O=C(c1ccncc1)N1CCC2(CC1)CN(c1cccc(-c3ccccc3)c1)C2 CHEMBL1399058 Potency 31.6 nM
C[C@@H]1C[C@@H]2[C@H]3CCC4=CC(=O)C=C[C@]4(C)[C@]3(Cl)[C@@H](O)C[C@@]2(C)[C@@]1(O)C(=O)CO CHEMBL1592340 Potency 31.6 nM
CC(C)c1ccc(C(O)(C(=O)O)c2ccc(C(C)C)cc2)cc1 CHEMBL1411808 Potency 31.6 nM
CC[C@]1(O)C[C@@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1 CHEMBL378544 Potency 31.6 nM
COc1cccc2c1Cc1c(Nc3ccc4c(c3)OCCO4)n[nH]c1-2 CHEMBL2323957 IC50 34.0 nM
CC1CC2C(C(O)CC3(C)C2CCC3(O)C(=O)CO)C2(C)C=CC(=O)C=C12 CHEMBL190259 Potency 39.8 nM
CCN(CC)CC[n+]1ccc2c(C)c3[nH]c4ccc(O)cc4c3c(C)c2c1 CHEMBL1790009 Potency 39.8 nM
Oc1cccnc1CN1CCCCC1 CHEMBL1437522 Potency 39.8 nM
CC(=O)[C@]1(O)CC[C@@H]2[C@H]3C[C@@H](C)C4=CC(=O)CC[C@@]4(C)[C@H]3[C@@H](O)C[C@]21C CHEMBL1407576 Potency 39.8 nM
COCC(=O)N1CCC2(CC1)CN(c1ccccn1)C2 CHEMBL1399394 Potency 39.8 nM
C[C@@H]1O[C@@H](O[C@H]2C[C@@H](O)[C@@]3(CO)C4[C@H](O)C[C@]5(C)[C@@H](C6=CC(=O)OC6)CC[C@]5(O)[C@H]4CC[C@@]3(O)C2)[C@@H](O)[C@H](O)[C@H]1O CHEMBL2069120 Potency 39.8 nM
CC(=O)OCC(=O)[C@@]1(O)CC[C@@H]2[C@H]3CCC4=CC(=O)CC[C@]4(C)[C@]3(F)[C@@H](O)C[C@@]21C CHEMBL1355220 Potency 39.8 nM
Oc1c(I)cc(Cl)c2cccnc12 CHEMBL497 Potency 39.8 nM
CN1C(=O)[C@@]23C[C@]4([C@]56C[C@@]78SS[C@@](CO)(C(=O)N7[C@H]5Nc5ccccc56)N(C)C8=O)c5ccccc5N[C@@H]4N2C(=O)[C@]1(CO)SS3 CHEMBL1089316 IC50 40.0 nM
COc1ccc(NC(=O)c2noc3ccccc23)cc1 CHEMBL5208153 IC50 40.0 nM
O=C(Nc1ccc(Cl)cc1)c1noc2ccccc12 CHEMBL5194403 IC50 41.0 nM
O=C(Nc1ccc2scnc2c1)c1noc2ccccc12 CHEMBL5197796 IC50 42.0 nM
O=[N+]([O-])c1ccc2c(c1)S(=O)(=O)C=C2 CHEMBL1337170 IC50 43.0 nM
CC(C)(O)C1Cc2cc3cc(-c4cccc(O)c4)oc3cc2O1 CHEMBL1795434 IC50 46.0 nM
CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@](C)(C(=O)OCCOc4cnc5ccccc5c4)CC[C@]3(C)CC[C@]12C CHEMBL4849804 IC50 50.0 nM
CC(COc1ccccc1)NC(C)C(O)c1ccc(O)cc1 CHEMBL1197051 Potency 50.1 nM
COc1cc(OC)c(/C=C2/C(=O)Nc3ccccc32)c(OC)c1 CHEMBL489156 Potency 50.1 nM
C[C@H](NCCc1ccc(O)cc1)[C@@H](O)c1ccc(O)cc1 CHEMBL1321005 Potency 50.1 nM
C[C@H]1C[C@@H]2[C@H]([C@@H](O)C[C@@]3(C)[C@H]2CC[C@]3(O)C(=O)CO)[C@@]2(C)C=CC(=O)C=C12 CHEMBL650 Potency 50.1 nM
C[C@H]1C[C@H]2[C@H]3CCC4=CC(=O)C=C[C@@]4(C)[C@]3(F)[C@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O CHEMBL1369009 Potency 50.1 nM
CC[C@@H]1CN2CCc3cc(OC)c(OC)cc3[C@H]2C[C@@H]1C[C@@H]1NCCc2cc(O)c(OC)cc21 CHEMBL1357014 Potency 50.1 nM
CN(C)c1ccc(-c2nc(N(C)C)c3ccccc3n2)cc1 CHEMBL1475562 Potency 50.1 nM
CC(=O)[C@@H]1CC[C@@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@@]4(C)[C@H]3[C@H](O)C[C@]21C CHEMBL1520025 Potency 50.1 nM
CC(C)(O)C1Cc2cc3cc(-c4ccccc4)oc3cc2O1 CHEMBL1795441 IC50 54.0 nM
CCOC(=O)COc1ccc(-c2cc3cc4c(cc3o2)OC(C(C)(C)O)C4)cc1 CHEMBL1795436 IC50 54.0 nM
CO[C@H]1/C=C\C=C(/C)C(=O)NC2=CC(=O)C(NCCN(C)C)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(\C)[C@@H]1OC(N)=O)C2=O CHEMBL383824 IC50 57.0 nM
C[C@@]12C[C@@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]43C)[C@H]1CC[C@H]2C(=O)CO CHEMBL1533938 Potency 63.1 nM
CC[C@]1(O)C[C@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C=O)[C@H]3[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1 CHEMBL501867 Potency 63.1 nM
C[C@@]12CCC(=O)C=C1CC[C@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@H]1CC[C@@]2(O)C(=O)COC(=O)C1CCCC1 CHEMBL1476274 Potency 63.1 nM
CC1CCc2cc(F)cc3c(O)c(C(=O)Nc4cnccn4)c(=O)n1c23 CHEMBL1483751 Potency 63.1 nM
CCNC[C@H](O)c1cccc(O)c1 CHEMBL1160706 Potency 63.1 nM
C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)CO CHEMBL110739 Potency 63.1 nM
C[C@H]1C[C@@H](C)C(=O)[C@@H]([C@H](O)CC2CC(=O)NC(=O)C2)C1 CHEMBL1358722 Potency 63.1 nM
CC[C@]1(OC(=O)CN)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1 CHEMBL1447579 Potency 63.1 nM
Cc1ccc(S(=O)(=O)N[C@H](C(=O)O)C(C)C)cc1 CHEMBL1410826 Potency 63.1 nM
CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@](C)(C(=O)OCC(=O)Nc4cc(C)on4)CC[C@]3(C)CC[C@]12C CHEMBL4849133 IC50 70.0 nM
O=C(Nc1ccc2ccccc2c1)c1noc2ccccc12 CHEMBL5192165 IC50 75.0 nM
C[C@@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@H](O)C[C@]2(C)[C@@H]1CC[C@]2(O)C(=O)CO CHEMBL1474522 Potency 79.4 nM
CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1 CHEMBL65 Potency 79.4 nM
C[C@@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@H]1C[C@@H](O)[C@H]2O CHEMBL1437142 Potency 79.4 nM
C[C@@H]1O[C@H](O[C@H]2C[C@@H](O)[C@@]3(CO)[C@H]4[C@@H](O)C[C@]5(C)[C@@H](C6=CC(=O)OC6)CC[C@]5(O)[C@H]4CC[C@]3(O)C2)[C@@H](O)[C@H](O)[C@@H]1O CHEMBL1326714 Potency 79.4 nM
Nc1c(Br)cc2oc(-c3ccccc3)nc2c1Br CHEMBL1430695 Potency 79.4 nM
Cc1ccc(/N=N\c2c(O)c(S(=O)(=O)O)cc3cc(S(=O)(=O)O)ccc23)c(C)c1 CHEMBL1356392 Potency 79.4 nM
O=C(c1ccco1)N1CCC2(CC1)CN(c1cccc(-c3ccccc3)c1)C2 CHEMBL1436059 Potency 79.4 nM
C=C(C)[C@H]1Cc2c(ccc3c2O[C@H]2COc4cc(OC)c(OC)cc4[C@@H]2C3=O)O1 CHEMBL1518927 Potency 79.4 nM
CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C CHEMBL1390 Potency 79.4 nM
CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@](C)(C(=O)OCCOc4ccc5ccc(=O)oc5c4)CC[C@]3(C)CC[C@]12C CHEMBL4852306 IC50 80.0 nM
CCOc1ccccc1-n1c(CN2CCNCC2)nc2ccccc2c1=O CHEMBL1836238 IC50 90.0 nM
CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@](C)(C(=O)OCC(=O)Nc4cnc5ccccc5c4)CC[C@]3(C)CC[C@]12C CHEMBL4860987 IC50 90.0 nM
O=C(CSc1ncnc2[nH]cnc12)c1ccccc1 CHEMBL1331587 Potency 100.0 nM
CCCCC[C@H](O)/C=C/C1=C(CCCCCCC(=O)O)C(=O)CC1 CHEMBL1561148 Potency 100.0 nM
CN1NC(=N)c2cn([C@H]3O[C@@H](CO)[C@@H](O)[C@@H]3O)c3ncnc1c23 CHEMBL1552708 Potency 100.0 nM
Cc1cnc(CNc2ncnc3ccc(-c4ccccc4C(F)(F)F)cc23)cn1 CHEMBL1591374 Potency 100.0 nM
OC(Cc1cccnc1)(c1ccccc1)c1ccccc1 CHEMBL1417375 Potency 100.0 nM
COc1ccccc1C(=O)Nc1cc(Cl)ccc1O CHEMBL442581 Potency 100.0 nM
CNC[C@H](O)c1cccc(O)c1 CHEMBL1200339 Potency 100.0 nM
N=C(Cc1ccccc1)NCC(=O)O CHEMBL1253215 Potency 100.0 nM
Cc1cc(OCc2nc(N)nc(N)c2-c2ccc(Cl)c(Cl)c2)ccc1[N+](=O)[O-] CHEMBL265177 Potency 100.0 nM
COc1ccc2c(c1)c(CC(=O)OCC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1 CHEMBL189171 Potency 100.0 nM
Nc1nc(SCCc2ccccc2)c2nc[nH]c2n1 CHEMBL1437990 Potency 100.0 nM
C[C@@H]1O[C@@H](O[C@H]2C[C@@H](O)[C@]3(CO)[C@@H]4[C@@H](O)C[C@]5(C)[C@H](C6=CC(=O)OC6)CC[C@@]5(O)[C@H]4CC[C@@]3(O)C2)[C@H](O)[C@H](O)[C@@H]1O CHEMBL1512393 Potency 100.0 nM
C[N+](C)(C)c1ncnc2c1ncn2[C@@H]1C[C@H](O)[C@@H](CO)O1 CHEMBL1551016 Potency 100.0 nM
CC(=O)OC[C@@H]1O[C@@H](O/N=C2/C[C@@H](O)[C@@H](O)[C@@H]3[C@@H]4C(=O)N(c5cccc(Oc6ccccc6)c5)C(=O)[C@H]4CC[C@@H]23)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]1OC(C)=O CHEMBL1590601 Potency 100.0 nM
COc1cccc(Cn2c(NCC(C)C)nc3c2c(=O)n(C)c(=O)n3C)c1 CHEMBL1526927 Potency 100.0 nM
CCOc1ccc(C2=Nn3c(nnc3-c3ccccc3OC)SC2)cc1 CHEMBL1342336 Potency 100.0 nM
CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C CHEMBL110691 Potency 100.0 nM
O=C1CC(c2ccccc2)n2nc(NS(=O)(=O)c3ccccc3)nc2N1 CHEMBL1422043 Potency 100.0 nM
CCNc1ncc2nc(-c3ccc(Cl)cc3)c(=O)n(Cc3ccc(F)cc3)c2n1 CHEMBL1434308 Potency 100.0 nM
COc1ccc(Cc2ccc3nc(O)cc(C)c3c2)cc1S(=O)(=O)O CHEMBL507159 Potency 100.0 nM
C=CCn1cnc2c(c1=O)c1nc3ccccc3nc1n2-c1ccc(Cl)cc1 CHEMBL1597390 Potency 100.0 nM
COc1ccc(NC(=O)N2CCC3(CC2)CCN(C(=O)c2ccco2)CC3)cc1 CHEMBL1436526 Potency 100.0 nM
N=C(N)NNC(=O)C(=O)O CHEMBL1486555 Potency 100.0 nM
N=c1ccn2c(n1)O[C@H]1[C@@H](OP(=O)(O)O)[C@H](CO)O[C@H]12 CHEMBL1442094 Potency 100.0 nM
COc1c(C(=O)Cc2ccccc2F)ccc2c1C=CC(C)(C)O2 CHEMBL4209785 IC50 100.0 nM
COc1ccc(-c2cc3cc4c(cc3o2)OC(C(C)(C)O)C4)cc1 CHEMBL1795440 IC50 110.0 nM
O=C(/C=C/Oc1ccc(C23CC4CC(CC(C4)C2)C3)cc1)Nc1cccc(C(=O)OCCN2CCOCC2)c1 CHEMBL2178399 IC50 120.0 nM
CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@](C)(C(=O)OCC(=O)NCc4cn(-c5ccc(Cl)c(Cl)c5)nn4)CC[C@]3(C)CC[C@]12C CHEMBL4861387 IC50 120.0 nM
CC(C)C[C@@H]1NC(=O)[C@H](CS)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)NC1=O CHEMBL4584063 Kd 124.0 nM
C[C@]12C=CC(=O)C=C1CC[C@@H]1[C@H]3C[C@@H](O)[C@](O)(C(=O)CO)[C@]3(C)C[C@H](O)[C@]12F CHEMBL1571851 Potency 125.9 nM
c1ccc2c3nc[nH]c(N4CCN(C5CCCCC5)CC4)c-3nc2c1 CHEMBL1325388 Potency 125.9 nM
O=c1c(-c2ccc(Cl)cc2)nc2cnc(Nc3ccccc3)nc2n1C[C@H]1CCCO1 CHEMBL1563501 Potency 125.9 nM
CN(C)c1ncc2nc(-c3cc(F)cc(F)c3)c(=O)n(Cc3cccs3)c2n1 CHEMBL1327772 Potency 125.9 nM
CC(C)CO/N=C1/C[C@@H](O)[C@@H](O)[C@@H]2[C@@H]3C(=O)N(C(C)(C)C)C(=O)[C@H]3CC[C@@H]12 CHEMBL1394456 Potency 125.9 nM
C[C@@H]1O[C@H](O[C@@H]2[C@H](C)O[C@H](O[C@@H]3[C@H](C)O[C@H](O[C@H]4CC[C@]5(C)[C@@H](CC[C@@H]6[C@H]5C[C@@H](O)[C@]5(C)[C@@H](C7=CC(=O)OC7)CC[C@]65O)C4)C[C@@H]3O)C[C@@H]2O)C[C@H](O)[C@@H]1O CHEMBL1477182 Potency 125.9 nM
COc1ccc(-c2nn3c(C4CCCCC4)nnc3s2)cc1OC CHEMBL1353133 Potency 125.9 nM
CN(C)c1ccc(C2C3C(=O)N(c4ccc(C(=O)O)cc4)C(=O)C3ON2c2ccccc2)cc1 CHEMBL1313103 Potency 125.9 nM
CC(COc1ccccc1)NC(C)C(O)c1ccc(O)cc1 CHEMBL559180 Potency 125.9 nM
COc1ccccc1-c1cc(NCc2ccccc2)ncn1 CHEMBL1396898 Potency 125.9 nM
CCNc1ncc2nc(-c3ccc(Cl)cc3)c(=O)n(Cc3cccs3)c2n1 CHEMBL1553766 Potency 125.9 nM
O=C(c1ccncc1)N1CCC[C@@]2(CCN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)C1 CHEMBL1531699 Potency 125.9 nM
CC(C)(C)c1cc(C=C(C#N)C#N)cc(C(C)(C)C)c1O CHEMBL78150 Potency 125.9 nM
CCNc1ncc2nc(-c3cccs3)c(=O)n(Cc3cccc(OC)c3)c2n1 CHEMBL1375046 Potency 125.9 nM
CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C CHEMBL1091 Potency 125.9 nM
CCOc1cc2nc(-c3ccc(OC)c(OC)c3)nc(N3CCOCC3)c2cc1OC CHEMBL1403102 Potency 125.9 nM
C[C@@]12C=C(c3c(O)cc(-c4cc5ccc(O)cc5o4)cc3O)C[C@@H](C1)c1ccc(O)cc1O2 CHEMBL563553 IC50 140.0 nM
CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@](C)(C(=O)OCCOc4cc(C)oc(=O)c4)CC[C@]3(C)CC[C@]12C CHEMBL4854524 IC50 150.0 nM
CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@](C)(C(=O)OCCOc4cc(=O)oc5ccccc45)CC[C@]3(C)CC[C@]12C CHEMBL4848196 IC50 150.0 nM
COc1cc2cc(c1Cl)N(C)C(=O)C[C@H](OC(=O)C(C)C)[C@]1(C)O[C@@H]1[C@@H](C)[C@H]1C[C@](O)(NC(=O)O1)[C@@H](OC)/C=C\C=C(\C)C2 CHEMBL1552403 Potency 158.5 nM
CC(CC(=O)O)(CC(=O)O)c1ccccc1 CHEMBL76143 Potency 158.5 nM
c1ccc(CN2CCN(c3nc(-c4ccccn4)nc4ccccc34)CC2)cc1 CHEMBL1386172 Potency 158.5 nM
CC(C)NC[C@H](O)c1ccc(O)c(O)c1 CHEMBL2062275 Potency 158.5 nM
N#Cc1c(NC(=O)C(F)(F)F)sc2c3c(=O)c4ccccc4c(=O)c=3oc3ccccc3c12 CHEMBL1372282 Potency 158.5 nM
COC[C@@H]1OC(=O)c2coc3c2[C@]1(C)C1=C(C3=O)[C@H]2CCC(=O)[C@]2(C)C[C@@H]1OC(C)=O CHEMBL1474372 Potency 158.5 nM
Fc1ccccc1-c1nc(N2CCCCC2)c2ccccc2n1 CHEMBL1349507 Potency 158.5 nM
Oc1c(C(O)(c2ccccc2)c2ccc3ccccc3c2O)ccc2ccccc12 CHEMBL1367656 Potency 158.5 nM
CC[C@H](NC(C)C)[C@H](O)c1ccc(O)c(O)c1 CHEMBL1472703 Potency 158.5 nM
COC(=O)C/C=C\[C@@H](C)[C@@H](/C=N\O[C@@H](C)c1cc(-c2c(C)cc(C)cc2C)no1)NS(=O)(=O)c1ccc(C)cc1 CHEMBL1356391 Potency 158.5 nM
Cc1noc(C)c1C(=O)N1CCC2(CCCN(c3ncccn3)C2)CC1 CHEMBL1314324 Potency 158.5 nM
NNc1c(C(N)=O)c2c(N)ncnc2n1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O CHEMBL1565228 Potency 158.5 nM
CN(C)c1ccc(-c2ccc3ncnc(-n4ccnc4)c3c2)cc1 CHEMBL1396595 Potency 158.5 nM
COc1ccc(-c2cnnc(CCCn3ccnc3-c3ccccc3)n2)cc1 CHEMBL1354913 Potency 158.5 nM
O=C1CCCC=C1[C@@H](O)C1CCCCC1 CHEMBL1400014 Potency 158.5 nM
c1ccc(CSc2nnc3c4ccccc4c4ccccc4c3n2)cc1 CHEMBL1358395 Potency 158.5 nM
O=C1/C(=N/CCc2cc(Br)c(O)c(Br)c2)C=C(O)c2cccnc21 CHEMBL336095 Potency 158.5 nM
c1ccc2c[n+](Cc3ccnc4ccccc34)ccc2c1 CHEMBL1527317 Potency 158.5 nM
CN1CCC2(CC1)CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2 CHEMBL1558456 Potency 158.5 nM
C[C@H]1CC[C@@H]2[C@@H](C)C(=O)O[C@H]3O[C@@]4(C)CC[C@H]1[C@@]32OO4 CHEMBL1401626 Potency 158.5 nM
CNC[C@H](O)c1ccc(O)cc1 CHEMBL443893 Potency 158.5 nM
C#C[C@]1(O)CC[C@@H]2[C@H]3CCC4=Cc5oncc5C[C@]4(C)[C@@H]3CC[C@@]21C CHEMBL1493294 Potency 158.5 nM
Cc1cc(C)c(/C=C2/C(=O)Nc3ccccc32)[nH]1 CHEMBL105739 Potency 158.5 nM
CCOc1ccccc1-n1c(CN2CCCNCC2)nc2ccccc2c1=O CHEMBL1836239 IC50 160.0 nM
CCOP(=O)(OCC)C(NC(=O)COC(=O)[C@]1(C)CC[C@]2(C)CC[C@]3(C)C4=CC=C5C(=CC(=O)C(O)=C5C)[C@]4(C)CC[C@@]3(C)[C@@H]2C1)c1ccc(OC)cc1 CHEMBL4854660 IC50 160.0 nM
CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@](C)(C(=O)OCC(=O)Nc4ccc(F)nc4)CC[C@]3(C)CC[C@]12C CHEMBL4875514 IC50 160.0 nM
CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@](C)(C(=O)OCCOc4ccc5cccnc5c4)CC[C@]3(C)CC[C@]12C CHEMBL4856721 IC50 170.0 nM
COc1cccc(NC(=O)c2noc3ccccc23)c1 CHEMBL5188937 IC50 170.0 nM
CC(=O)O/C(=C1/C[C@H]2[C@@H]3CC=C4C[C@@H](OC(C)=O)CC[C@]4(C)[C@@H]3CC[C@]2(C)C1=O)C(F)(F)F CHEMBL1442459 Potency 199.5 nM
NC(Cc1ccccc1)(C(=O)O)C(=O)O CHEMBL1371355 Potency 199.5 nM
CC(=O)/C(C#N)=C1\NC(=O)C(Cc2ccccc2Cl)S1 CHEMBL1306263 Potency 199.5 nM
CCN(CC)CCN1c2ccccc2Sc2ccc3ccccc3c21 CHEMBL1485000 Potency 199.5 nM
N#Cc1ccc(OC(=O)c2ccc(NC(=N)N)cc2)cc1 CHEMBL1408879 Potency 199.5 nM
O=S1(=O)OC(c2ccc(O)cc2)(c2ccc(O)cc2)c2ccccc21 CHEMBL258921 Potency 199.5 nM
CO[C@H]1COC(=O)C/C=C\[C@H](C)[C@@H](NS(=O)(=O)c2ccc(C)cc2)COC(=O)CCC[C@@H]1C CHEMBL1356463 Potency 199.5 nM
C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO CHEMBL389621 Potency 199.5 nM
O=C(O)[C@H]1OC(O)[C@H](O)[C@H](O)[C@@H]1O CHEMBL2068684 Potency 199.5 nM
N/C(CSS(=O)(=O)O)=N\[C@@H]1C[C@H]2CC[C@@H]1C2 CHEMBL1433939 Potency 199.5 nM
O=C1c2cccc(O)c2C(=O)c2c(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)cccc21 CHEMBL1399656 Potency 199.5 nM
Cc1ncc(CSc2ccccc2N)c(CO)c1O CHEMBL1604036 Potency 199.5 nM
CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)[C@H]1c1cccc(Cl)c1Cl CHEMBL254609 Potency 199.5 nM
CN1Cc2c(N3CCOCC3)nc(SCc3ccccc3)c(C#N)c2CC1(C)C CHEMBL1499275 Potency 199.5 nM
C[C@@]12C=CC(=O)C=C1CC[C@@H]1[C@@H]2[C@H](O)C[C@]2(C)[C@@H]1CC[C@]2(O)C(=O)CO CHEMBL1360778 Potency 199.5 nM
O=C(O)[C@H](Cc1c[nH]cn1)N1C(=O)c2ccccc2C1=O CHEMBL1355217 Potency 199.5 nM
CCOC(=O)CCN1C(=O)[C@H]2[C@@H]3[C@H](O)[C@H](O)CC(=O)[C@H]3CC[C@H]2C1=O CHEMBL1448712 Potency 199.5 nM
CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C CHEMBL1527439 Potency 199.5 nM
COc1cc2c(c(OC)c1OC)-c1ccc(OC)c(=O)cc1[C@H](NC(C)=O)CC2 CHEMBL330320 Potency 199.5 nM
Oc1c(I)cc(I)c2cccnc12 CHEMBL86754 Potency 199.5 nM
COC(=O)Nc1nc2cc(C(=O)c3cccs3)ccc2[nH]1 CHEMBL9514 Potency 199.5 nM
COc1ccc(C(F)(F)F)cc1-n1c(CN2CCNCC2)nc2ccccc2c1=O CHEMBL1836179 IC50 200.0 nM
COC(=O)c1cccc(NC(=O)c2noc3ccccc23)c1 CHEMBL5174696 IC50 200.0 nM
Nc1ccc(NC(=O)Nc2cccc3c2C(=O)c2c-3n[nH]c2-c2ccc3c(c2)OCO3)cc1 CHEMBL253429 IC50 214.0 nM
O=C(O)c1cc(/N=N/c2ccc(S(=O)(=O)Nc3ccccn3)cc2)ccc1O CHEMBL421 Potency 223.9 nM
CCOP(=O)(OCC)C(NC(=O)COC(=O)[C@]1(C)CC[C@]2(C)CC[C@]3(C)C4=CC=C5C(=CC(=O)C(O)=C5C)[C@]4(C)CC[C@@]3(C)[C@@H]2C1)c1ccccc1 CHEMBL4855426 IC50 240.0 nM
CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@](C)(C(=O)OCC(=O)Nc4ccc5ncccc5c4)CC[C@]3(C)CC[C@]12C CHEMBL4857949 IC50 240.0 nM
CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@](C)(C(=O)OCC(=O)Nc4ccc(F)cn4)CC[C@]3(C)CC[C@]12C CHEMBL4853725 IC50 250.0 nM
CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@](C)(C(=O)O)CC[C@]3(C)CC[C@]12C CHEMBL301982 IC50 250.0 nM
O=C(Nc1cccc(Cl)c1)c1noc2ccccc12 CHEMBL5202378 IC50 250.0 nM
Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O CHEMBL1554 Potency 251.2 nM
O=[N+]([O-])c1ccc(S(=O)(=O)Cc2ccccc2)c([N+](=O)[O-])c1 CHEMBL1489424 Potency 251.2 nM
Cc1ccccc1-c1ccc2ncnc(N3CCOCC3)c2c1 CHEMBL1434715 Potency 251.2 nM
CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3c(CN(C)C)c(O)ccc3nc2-1 CHEMBL1607 Potency 251.2 nM
CNC[C@H](O)c1cccc(O)c1 CHEMBL1215 Potency 251.2 nM
CCCC(=O)Nc1ccc(OC[C@@H](O)CNC(C)C)c(C(C)=O)c1 CHEMBL1455097 Potency 251.2 nM
C[C@@]12CC[C@H](O)C[C@@H]1CC[C@H]1[C@H]2CC[C@@]2(C)[C@@H](C3=CC(=O)OC3)CC[C@]12O CHEMBL1591205 Potency 251.2 nM
CC(C)CN1CC2(CCN(C(=O)c3ccco3)CC2)C1 CHEMBL1599748 Potency 251.2 nM
CC1=C/C(=C(/c2ccc(O)c(C)c2)c2ccccc2C(=O)O)C=CC1=O CHEMBL1437054 Potency 251.2 nM
O=C(O)c1cccc(CN2CCCCC2)c1 CHEMBL1496013 Potency 251.2 nM
COc1cccc(-c2cncnc2NCCc2c[nH]c3ccc(OC)cc23)c1 CHEMBL1484261 Potency 251.2 nM
O=C(Oc1ccccc1)N1CCC2(CCCN(c3ncccn3)C2)CC1 CHEMBL1437325 Potency 251.2 nM
[N-]=[N+]=N[C@@H]1[C@H](O)[C@H](CO)O[C@@H]1n1cnc2c(N)ncnc21 CHEMBL1318464 Potency 251.2 nM
O=C(O)[C@@H]1[C@@H](C(=O)O)[C@]23C[C@@]2(C(=O)O)[C@]2(C(=O)O)CCC3=C3CCC[C@@]312 CHEMBL2374026 Potency 251.2 nM
CO/N=C1/c2cc(OC)ccc2O[C@@H](c2cccc(OC)c2)[C@H]1O CHEMBL1594350 Potency 251.2 nM
Cc1c2ccccc2c(CSC(=N)N)c2ccccc12 CHEMBL1409073 Potency 251.2 nM
N#Cc1ccccc1-c1ccc2ncnc(NCc3cccs3)c2c1 CHEMBL1590123 Potency 251.2 nM
COc1cccc([C@@H]2Oc3ccc(Br)cc3C(=O)[C@H]2O)c1 CHEMBL1409720 Potency 251.2 nM
CCC1(C)Cc2c(sc3c2c(=O)n(C)c2nnc(SCc4ccccc4)n32)CO1 CHEMBL1300217 Potency 251.2 nM
CCCCc1nc(O)c2c3c(sc2n1)CCC3 CHEMBL1400198 Potency 251.2 nM
c1coc(-c2nnc3sc(-c4cccs4)nn23)c1 CHEMBL1421246 Potency 251.2 nM
C[C@]12Cc3cn4c(nc3C=C1CC[C@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@@]2(O)C#N)nc1ccccc14 CHEMBL1320743 Potency 251.2 nM
CO[C@@H]1COC(=O)C/C=C/[C@@H](C)[C@@H]2C=C[C@@H](O)[C@@H](COC(=O)C/C=C\[C@H]1C)O2 CHEMBL1592717 Potency 251.2 nM
CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1 CHEMBL38 Potency 251.2 nM
Nc1cc2c(nc3c4ccccc4c(N)cc3[n+]2-c2cccc3ccccc23)c2ccccc12 CHEMBL1526964 Potency 251.2 nM
CC(=O)OC(C)(C)/C=C/C(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@H](C[C@H](O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C CHEMBL507237 IC50 270.0 nM
c1ccc2c(c1)Cc1c(Nc3ccc4c(c3)OCO4)n[nH]c1-2 CHEMBL2323955 IC50 270.0 nM
Cc1ccc(-c2cc3cc4c(cc3o2)OC(C(C)(C)O)C4)cc1 CHEMBL1795442 IC50 310.0 nM
O=C(Nc1ccccc1)c1noc2ccccc12 CHEMBL5178011 IC50 310.0 nM
CCCCc1ccc2[nH]c(NC(=O)OC)nc2c1 CHEMBL528271 Potency 316.2 nM
COc1cccc(Cn2c(=O)c(-c3ccc(Cl)cc3)nc3cnc(N(C)C)nc32)c1 CHEMBL1476021 Potency 316.2 nM
O=[N+]([O-])c1ccc([C@@H](Nc2ccccc2)c2ccc3cccnc3c2O)cc1 CHEMBL1330020 Potency 316.2 nM
C[C@H]1CCC/C=C/C2C[C@H](O)CC2[C@H](O)/C=C/C(=O)O1 CHEMBL3192995 Potency 316.2 nM
N#C/C(=C\N1CCN(Cc2ccc3c(c2)OCO3)CC1)c1nc2ccccc2s1 CHEMBL1308455 Potency 316.2 nM
COc1ccc(Nc2cc(C)nc(-n3nc(C)cc3C)n2)cc1 CHEMBL1490339 Potency 316.2 nM
COC(=O)c1ccc(C2C(C(=O)c3ccc(OC)cc3)=C(O)C(=O)N2Cc2ccco2)cc1 CHEMBL1585547 Potency 316.2 nM
Cc1cc(C2CCCCC2)n(O)c(=O)c1 CHEMBL242580 Potency 316.2 nM
c1ccc(N2CCN(c3nc(-c4ccccn4)nc4ccccc34)CC2)cc1 CHEMBL1391287 Potency 316.2 nM
COC(=O)N1CCC2(CCCN(c3ccc(-c4ccccc4)cc3)C2)CC1 CHEMBL1551036 Potency 316.2 nM
Cc1ccc2[nH]c3c(N4CCN(Cc5ccccc5)CC4)ncnc3c2c1 CHEMBL1299470 Potency 316.2 nM
CN(C)c1ncnc2ccc(-c3ccc4c(c3)OCO4)cc12 CHEMBL1446523 Potency 316.2 nM
C[C@H]1CCC/C=C/[C@H]2C[C@H](OC(=O)CN(C)C)C[C@@H]2[C@@H](O)/C=C\C(=O)O1 CHEMBL2373582 Potency 316.2 nM
COc1ccccc1-c1nnc2n1N=C(c1ccc(O)c(O)c1)CS2 CHEMBL1393480 Potency 316.2 nM
CN(Cc1cc(C(C)(C)C)cc(Br)c1O)Cc1cc(C(C)(C)C)cc(Br)c1O CHEMBL1516622 Potency 316.2 nM
COc1ccccc1CNc1cc(-c2ccccc2OC)ncn1 CHEMBL1551557 Potency 316.2 nM
CC(C)=NO[C@@H](C)CN1CCCc2nc(C)c(C)cc21 CHEMBL1514604 Potency 316.2 nM
CCOC(=O)[N-]c1c[n+](N2CCOCC2)no1 CHEMBL1329455 Potency 316.2 nM
COc1cc([C@H]2c3cc4c(cc3[C@@H](O[C@H]3O[C@H]5CO[C@@H](C)O[C@H]5[C@@H](O)[C@@H]3O)[C@@H]3COC(=O)[C@H]23)OCO4)cc(OC)c1O CHEMBL1434216 Potency 316.2 nM
CCNc1ncc2nc(-c3ccc(Cl)cc3)c(=O)n(Cc3cccc(OC)c3)c2n1 CHEMBL1401031 Potency 316.2 nM
C[C@@H]1c2ccccc2Cn2cc3c(c21)C(=O)c1cccc(O[P@@](=O)([O-])OCc2ccccc2)c1C3=O CHEMBL2028181 Potency 316.2 nM
CC[C@]1(O)C[C@H]2CN(CCc3c([nH]c4ccccc34)[C@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@@H]3[C@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1 CHEMBL1315323 Potency 316.2 nM
COc1ccc(-n2c(C)c(C(C)=O)c3cc(O)ccc32)cc1 CHEMBL1502224 Potency 316.2 nM
C[C@H](N)[C@H](O)c1cccc(O)c1 CHEMBL2062343 Potency 316.2 nM
CC(C)OC(=O)c1c2nc3ccccc3nc2n2c1nc(O)c1ccccc12 CHEMBL1598413 Potency 316.2 nM
COc1ccccc1-c1ccc(C(=O)NCCc2ccccc2F)nc1 CHEMBL4447149 IC50 320.0 nM
O=C(COc1ccc(C23CC4CC(CC(C4)C2)C3)cc1)Nc1cccc(C(=O)O)c1 CHEMBL219673 IC50 350.0 nM
CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@](C)(C(=O)OCC(=O)Nc4cccc5cccnc45)CC[C@]3(C)CC[C@]12C CHEMBL4866598 IC50 350.0 nM
CC(C)(O)C1Cc2cc3cc(-c4cc(F)cc(F)c4)oc3cc2O1 CHEMBL1795443 IC50 360.0 nM
COc1c(C(=O)Cc2cccc(F)c2)ccc2c1C=CC(C)(C)O2 CHEMBL4214693 IC50 360.0 nM
CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@](C)(C(=O)OCC(=O)Nc4cccc5ncccc45)CC[C@]3(C)CC[C@]12C CHEMBL4878396 IC50 360.0 nM
O=C1c2ccccc2-c2cnn(-c3ccc(O)cc3)c21 CHEMBL4643958 IC50 390.0 nM
COc1cccc(Cn2c(=O)c(-c3cccs3)nc3cnc(OCc4ccccc4)nc32)c1 CHEMBL1357520 Potency 398.1 nM
CCOC(=O)CCN1C(=O)[C@@H]2[C@H]3C(=CC[C@H]2C1=O)C(=O)[C@H]1O[C@H]1[C@H]3O CHEMBL1515385 Potency 398.1 nM
CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 CHEMBL1385840 Potency 398.1 nM
CCNc1ncc2nc(-c3ccc(Cl)cc3)c(=O)n(C3CC3)c2n1 CHEMBL1376954 Potency 398.1 nM
O=c1c(-c2ccc(F)cc2)nc2cnc(N3CCOCC3)nc2n1Cc1ccc(F)cc1 CHEMBL1315965 Potency 398.1 nM
CCNc1ncc2nc(-c3ccc(F)cc3)c(=O)n(CCc3ccccc3)c2n1 CHEMBL1591600 Potency 398.1 nM
COc1cccc(Cn2c(=O)c(-c3cccs3)nc3cnc(Nc4cccc(OC)c4)nc32)c1 CHEMBL1476670 Potency 398.1 nM
c1ccc(-c2nc(NCC3CCCO3)c3ccccc3n2)nc1 CHEMBL1429863 Potency 398.1 nM
COc1cccc(-c2ccc3ncnc(NCc4cccnc4)c3c2)c1 CHEMBL566899 Potency 398.1 nM
CC1CCc2cc(F)cc3c(O)c(C(=O)NCc4ccco4)c(=O)n1c23 CHEMBL1311072 Potency 398.1 nM
COc1cccc(Cn2c(=O)c(-c3cc(F)cc(F)c3)nc3cnc(N(C)C)nc32)c1 CHEMBL1327752 Potency 398.1 nM
Nc1ncnc2c1ncn2[C@H]1O[C@@H](C(=O)O)[C@@H](O)[C@H]1O CHEMBL1569958 Potency 398.1 nM
Oc1c([C@H](Nc2ccccn2)c2ccccc2)ccc2cccnc12 CHEMBL1450821 Potency 398.1 nM
O=c1cc(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 CHEMBL151 Potency 398.1 nM
O=C1c2ccccc2C(=O)C1c1ccc2ccccc2n1 CHEMBL1486465 Potency 398.1 nM
CCC(=O)Nc1nc2ccccc2n1Cc1ccccc1C CHEMBL1438389 Potency 398.1 nM
CC[C@@H]1CN2CCc3cc(OC)c(OC)cc3[C@H]2C[C@@H]1C[C@@H]1NCCc2cc(OC)c(OC)cc21 CHEMBL1435868 Potency 398.1 nM
CCNc1ncc2nc(-c3cc(F)cc(F)c3)c(=O)n(-c3ccc(OC)cc3)c2n1 CHEMBL1605510 Potency 398.1 nM
Cc1cc(/C=N/n2cnnc2)c(C)n1-c1ccc2c(c1)OCO2 CHEMBL3211562 Potency 398.1 nM
O=C1C(O)=C(C(CCc2ccccc2)C2=C(O)C(=O)c3ccccc3C2=O)C(=O)c2ccccc21 CHEMBL311489 Potency 398.1 nM
O=c1c(-c2ccc(F)cc2)nc2cnc(Oc3cccc(Cl)c3)nc2n1C[C@H]1CCCO1 CHEMBL1320206 Potency 398.1 nM
CC(C)NC[C@@H](O)c1ccc(O)c2ncccc12 CHEMBL1517724 Potency 398.1 nM
O=S(=O)(O)c1cc(O)ccc1O CHEMBL1514715 Potency 398.1 nM
CC(C)c1nccn1Cc1ccc(Cl)cc1Cl CHEMBL1331778 Potency 398.1 nM
C/C(=N\NC(=O)c1ccncc1)c1ccc2ccccc2c1O CHEMBL1526658 Potency 398.1 nM
CC(Sc1nc(N2CCCCC2)c2c(c1C#N)CCCC2)C(=O)O CHEMBL1499884 Potency 398.1 nM
Cn1c(NCc2cccnc2)nc2c1c(=O)n(Cc1ccccc1F)c(=O)n2C CHEMBL1569549 Potency 398.1 nM
CN(/N=C\c1ccccc1O)c1ccc2ccccc2n1 CHEMBL1330183 Potency 398.1 nM
CN(Cc1cc(Cl)cc(Cl)c1O)Cc1c(O)ccc2ccccc12 CHEMBL1488167 Potency 398.1 nM
CN(C)c1ncc2nc(-c3ccc(Cl)cc3)c(=O)n(Cc3cccs3)c2n1 CHEMBL1519472 Potency 398.1 nM
CCCCc1c(C)nn(-c2nnc3c4ccccc4n(C)c3n2)c1C CHEMBL1531932 Potency 398.1 nM
CC(C)OC(=O)C(C#N)c1nc2ccccc2nc1N1CCCC1 CHEMBL1384200 Potency 398.1 nM
Fc1ccc2[nH]c3c(N4CCSCC4)ncnc3c2c1 CHEMBL1571157 Potency 398.1 nM
N#Cc1cccc(-c2nc3cnc(Oc4cccc(Cl)c4)nc3n(C3CC3)c2=O)c1 CHEMBL1357381 Potency 398.1 nM
CCOc1ccccc1-n1c(CN2CCN(C(=O)c3ccco3)CC2)nc2ccccc2c1=O CHEMBL1345685 IC50 430.0 nM
CCOc1ccccc1-n1c(CN2CCN(C(C)=O)CC2)nc2ccccc2c1=O CHEMBL1836233 IC50 470.0 nM
O=C(Nc1cccc([N+](=O)[O-])c1)c1noc2ccccc12 CHEMBL5177951 IC50 480.0 nM
CC(C)(O)C1Cc2cc3cc(-c4ccc(OCc5ccccc5)cc4)oc3cc2O1 CHEMBL1795437 IC50 490.0 nM
CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@](C)(C(=O)OCC(=O)Nc4ccnc5ccccc45)CC[C@]3(C)CC[C@]12C CHEMBL4858190 IC50 490.0 nM
c1ccc(-c2cccc(CNc3nc(-c4ccccn4)nnc3-c3ccccc3)c2)cc1 CHEMBL2135309 EC50 500.0 nM
COc1cc(O)c2c(O)c3c(c4c2c1[C@@]1(C4)C(C)=CCCC1(C)C)[C@H](O)[C@@]1(O)CC(O)=C(C(N)=O)C(=O)[C@]1(O)C3=O CHEMBL1336155 Potency 501.2 nM
FC(F)(F)c1cccc(-c2nc3nc(Cl)c(Cl)nc3[nH]2)c1 CHEMBL1324032 Potency 501.2 nM
O=C1C=CC(=O)c2c(O)c(N3CCN(c4ccccn4)CC3)cc(O)c21 CHEMBL1703229 Potency 501.2 nM
CC(C)c1ccc(O)c(=O)c(O)c1 CHEMBL1324842 Potency 501.2 nM
CC(=O)[C@@]1(O)Cc2c(O)c3c(c(O)c2[C@H](O[C@H]2C[C@H](N)[C@H](O)[C@H](C)O2)C1)C(=O)c1ccccc1C3=O CHEMBL1515691 Potency 501.2 nM
COCCn1c(=O)c(-c2ccc(OC)cc2)nc2cnc(Nc3ccccc3)nc21 CHEMBL1593374 Potency 501.2 nM
NNc1nncn1N CHEMBL1523390 Potency 501.2 nM
CCNc1ncc2nc(-c3ccc(Cl)cc3)c(=O)n(C[C@H]3CCCO3)c2n1 CHEMBL1552839 Potency 501.2 nM
C[C@@]12CC[C@H]3[C@@H](CC[C@]4(O)C[C@H](O)CC[C@@]34C=O)[C@]1(O)CC[C@@H]2C1=CC(=O)OC1 CHEMBL1437139 Potency 501.2 nM
C=C(C)C1Cc2c(C)nn(-c3nc(C)cc(C)n3)c2C1 CHEMBL1468929 Potency 501.2 nM
O=C(/C=N/O)NCCCN1CCOCC1 CHEMBL3198611 Potency 501.2 nM
CCN(CC)c1ccc(C2Nc3cccc4cccc(c34)N2)c(O)c1 CHEMBL1469355 Potency 501.2 nM
COC(=O)C1=C(C)N=C2SC(C)C(=O)N2C1c1ccc(C(=O)OC)cc1 CHEMBL1311586 Potency 501.2 nM
C[C@H](N)[C@H](O)c1ccc(O)c(O)c1 CHEMBL677 Potency 501.2 nM
COc1ccccc1CNc1cc(-c2ccccc2C(F)(F)F)ncn1 CHEMBL1476851 Potency 501.2 nM
CCNc1ncc2nc(-c3ccc(OC)cc3)c(=O)n(CCc3ccccc3)c2n1 CHEMBL1396310 Potency 501.2 nM
COCC(=O)N1CCC2(CCCN(C(=O)Nc3cccc(F)c3)C2)CC1 CHEMBL1433760 Potency 501.2 nM
COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-] CHEMBL193 Potency 501.2 nM
CCc1cccc(CC)c1NC(=O)CN(CC(=O)O)CC(=O)O CHEMBL1323453 Potency 501.2 nM
COc1cccc(N2CCN(c3[nH]cnc4c5cc(F)ccc5nc3-4)CC2C)c1 CHEMBL1575588 Potency 501.2 nM
CCCCc1nc(N2CCNCC2)c(C#N)c2c1CSC(C)(C)C2 CHEMBL1300089 Potency 501.2 nM
Oc1ccccc1CNCc1ccccc1O CHEMBL1358806 Potency 501.2 nM
O=c1c(-c2cccs2)nc2cnc(N3CCOCC3)nc2n1Cc1cccs1 CHEMBL1606369 Potency 501.2 nM
CC(=O)Oc1ccc(C(c2ccc(OC(C)=O)cc2)c2ccccn2)cc1 CHEMBL942 Potency 501.2 nM
O=C(Nc1cccc(F)c1)N1CCCC2(CCN(S(=O)(=O)c3ccccc3)CC2)C1 CHEMBL1320662 Potency 501.2 nM
O=c1c(-c2ccc(F)cc2)nc2cnc(N3CCOCC3)nc2n1CCc1ccccc1 CHEMBL1518182 Potency 501.2 nM
C[C@H](Oc1ccc(Oc2cnc3ccc(Cl)cc3n2)cc1)C(=O)[O-] CHEMBL1592257 Potency 501.2 nM
COc1ccc(C[C@@H]2C(=O)N[C@H](C)C(=O)N(C)[C@@H]3C(=O)N(C)[C@@H](Cc4ccc(O)c(c4)Oc4ccc(cc4)[C@H]3O)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N2C)cc1 CHEMBL1530314 Potency 501.2 nM
COC(=O)N1CCC2(CCCN(c3ccncc3)C2)CC1 CHEMBL1592812 Potency 501.2 nM
COc1ccc(/C=C(/C#N)c2cccnc2)cc1OC CHEMBL1423437 Potency 501.2 nM
CN(C)c1ncc2nc(-c3ccccc3)c(=O)n(Cc3ccc(F)cc3)c2n1 CHEMBL1475750 Potency 501.2 nM
C#C[C@@]1(O)CC[C@@H]2[C@@H]3CCC4=CC(=O)CC[C@@]4(C)[C@H]3CC[C@]21C CHEMBL1375243 Potency 501.2 nM
COC(=O)CN(c1nc(C)c(Cl)c(OC)n1)S(=O)(=O)c1ccc(C)cc1 CHEMBL1541618 Potency 501.2 nM
OC1CCN(CCOc2cccc(Cn3nc(-c4nc(-c5ccc(OC(F)(F)F)cc5)no4)c4ccccc43)c2)CC1 CHEMBL4463406 IC50 550.0 nM
COc1ccccc1-c1cc2cc3c(cc2o1)OC(C(C)(C)O)C3 CHEMBL1795438 IC50 580.0 nM
NC(=O)c1ccnc(NC(=O)COc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 CHEMBL249027 IC50 600.0 nM
CC(C)(C)c1ccc(CNc2nc(-c3ccccn3)nnc2-c2ccccc2)cc1 CHEMBL2138065 EC50 600.0 nM
CO/N=C(/C(=O)OC)c1ccccc1COc1cccc(OCc2ccc(Cl)cc2)c1 CHEMBL4090212 IC50 600.0 nM
COc1ccc(C(C)C(=O)c2ccc(NCc3ccc(C#N)cc3)cc2OC)cc1OC CHEMBL4215206 IC50 600.0 nM
CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@](C)(C(=O)OCC(=O)NCc4cn(-c5ccccc5)nn4)CC[C@]3(C)CC[C@]12C CHEMBL4875459 IC50 600.0 nM
COc1ccc(-n2ncc3c2C(=O)c2ccccc2-3)cc1 CHEMBL4645257 IC50 610.0 nM
CN1CCN(CCOc2cccc(Cn3nc(-c4nc(-c5ccc(OC(F)(F)F)cc5)no4)c4ccccc43)c2)CC1 CHEMBL4435719 IC50 620.0 nM
C=CCNc1nc(-c2cccc(OC)c2O)nc2ccccc12 CHEMBL1455614 Potency 631.0 nM
CC(C)(C)c1cc(/C=C(\C#N)C(N)=S)cc(C(C)(C)C)c1O CHEMBL539947 Potency 631.0 nM
COc1ccc(-n2c(=O)c(-c3ccc(Cl)cc3)nc3cnc(N4CCOCC4)nc32)cc1 CHEMBL1612410 Potency 631.0 nM
CCOC(=O)N1CCN(c2[nH]cnc3c4cc(OC)ccc4nc2-3)CC1 CHEMBL1377807 Potency 631.0 nM
Cc1cccc(CNc2ncnc3ccc(-c4cccnc4)cc23)c1 CHEMBL1332463 Potency 631.0 nM
C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)COC(=O)CCC(=O)[O-] CHEMBL1200495 Potency 631.0 nM
O=c1cnc2cnc(Nc3ccccc3)nc2n1Cc1ccc(F)cc1 CHEMBL1405744 Potency 631.0 nM
CCOC(=O)/C(C#N)=c1/s/c(=C\C(=O)OC)c(=O)n1-c1ccccc1 CHEMBL2004160 Potency 631.0 nM
COc1ccc2[nH]cc(C(=O)CN(C)CCc3ccc(OC)c(OC)c3)c2c1 CHEMBL1467629 Potency 631.0 nM
C[C@]12C=CC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)COC(=O)CCC(=O)[O-] CHEMBL1412530 Potency 631.0 nM
CS(=O)(=O)N1CCC2(CC1)CN(C(=O)Nc1cccc(C#N)c1)C2 CHEMBL1435404 Potency 631.0 nM
CN(C)c1ncc2nc(-c3ccccc3)c(=O)n(-c3ccccc3)c2n1 CHEMBL1316158 Potency 631.0 nM
COc1cc(NCC[C@@H]2CCCCN2)c2ncccc2c1 CHEMBL1436324 Potency 631.0 nM
Nc1c(S(=O)(=O)O)cc(Nc2cccc(S(N)(=O)=O)c2)c2c1C(=O)c1ccccc1C2=O CHEMBL471225 Potency 631.0 nM
Cc1nc(O)c2c3c(sc2n1)CCCC3 CHEMBL1569893 Potency 631.0 nM
O=C(CSc1nc2ccccc2c2ccccc12)c1ccccc1 CHEMBL1368286 Potency 631.0 nM
O=C(Nc1cccnc1)c1cccnc1 CHEMBL1358838 Potency 631.0 nM
O=C(c1cccc(F)c1)N1CCC2(CC1)CN(c1cccc(-c3ccccc3)c1)C2 CHEMBL1408854 Potency 631.0 nM
CCNc1ncc2nc(CCc3ccccc3)c(=O)n(CCC#N)c2n1 CHEMBL1590270 Potency 631.0 nM
CC(=O)C1=C(O)C(=O)N(c2cccc(C(=O)O)c2)C1c1ccc(F)cc1 CHEMBL1471643 Potency 631.0 nM
COc1cccc([C@@H]2Oc3ccc(OC)cc3C(=O)[C@H]2O)c1 CHEMBL1334327 Potency 631.0 nM
NNC1=NC(=O)NC(=O)C1 CHEMBL1437709 Potency 631.0 nM
CN(CC(=O)O)Cc1c(O)c(Cl)cc(Cl)c1Cl CHEMBL1408498 Potency 631.0 nM
CN(CCC(=O)O)S(=O)(=O)c1ccccc1 CHEMBL1329117 Potency 631.0 nM
COc1ccc2[nH]cc(CCNc3ncncc3-c3ccccc3C(F)(F)F)c2c1 CHEMBL1450521 Potency 631.0 nM
CC(=O)N1CCC2(CC1)CCN(C(=O)Nc1cccc(C#N)c1)CC2 CHEMBL1553863 Potency 631.0 nM
COCCn1c(=O)c(-c2cn(C)c3ccccc23)nc2cnc(OCc3ccccc3)nc21 CHEMBL1592580 Potency 631.0 nM
CCC(NC(=O)Nc1nnc(C(F)(F)F)s1)(C(F)(F)F)C(F)(F)F CHEMBL1607568 Potency 631.0 nM
COc1ccccc1CN1CCCC2(CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)C1 CHEMBL1590616 Potency 631.0 nM
C#CCSC1=C(C#N)C(c2cccs2)/C(=C(/O)OCC)C(C)=N1 CHEMBL3209312 Potency 631.0 nM
O=C(c1cnccn1)N1CCC2(CCCN(C(c3ccccc3)c3ccccc3)C2)CC1 CHEMBL1475620 Potency 631.0 nM
CCNc1ncc2nc(-c3ccc(F)cc3)c(=O)n(CCC#N)c2n1 CHEMBL1317306 Potency 631.0 nM
Nc1ccc(/N=N\c2ccccc2)c(N)n1 CHEMBL1355537 Potency 631.0 nM
COc1ccc(Oc2ncc3nc(-c4ccc(F)cc4)c(=O)n(CCC#N)c3n2)cc1 CHEMBL1515315 Potency 631.0 nM
O=C1CCCc2cc(NC(=O)c3noc4ccccc34)ccc21 CHEMBL5190853 IC50 640.0 nM
CC(=O)c1cccc(NC(=O)c2noc3ccccc23)c1 CHEMBL5209002 IC50 640.0 nM
COc1cc(O)cc2c1/C(=C\c1ccc(O)cc1)C(=O)O2 CHEMBL1164845 IC50 690.0 nM
COC(=O)c1cccc(NC(=O)COc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 CHEMBL373396 IC50 700.0 nM
O=C1C2=C3C4=[N+](CCc5c[nH]c1c54)[C@@H]1C(=O)C=C4S[C@@H](C[C@@]43[C@H]1O)N2 CHEMBL1194747 IC50 730.0 nM
COC(=O)c1cccc(NC(=O)/C=C/Oc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 CHEMBL2178407 IC50 740.0 nM
COc1c(C(=O)Cc2ccc(O)cc2)ccc2c1C=CC(C)(C)O2 CHEMBL4206967 IC50 790.0 nM
Cc1ccc(-n2ncc3c2C(=O)c2ccccc2-3)cc1 CHEMBL4635527 IC50 790.0 nM
CCOC(=O)C1/C(=N\O)CC(C)(O)C(C(=O)OCC)C1c1ccc(OC)c(OC)c1 CHEMBL3212790 Potency 794.3 nM
CN(C)c1cc2c(Nc3ccc4c(cnn4Cc4ccccc4)c3)ncnc2cn1 CHEMBL30432 Potency 794.3 nM
O=C(O)c1ccc(N[C@H](c2ccccc2)c2ccc3cccnc3c2O)cc1 CHEMBL1454730 Potency 794.3 nM
COC(=O)Nc1nc2cc(C(=O)c3ccccc3)ccc2[nH]1 CHEMBL685 Potency 794.3 nM
COc1cccc(-c2ccc3ncnc(NCc4ccccc4)c3c2)c1 CHEMBL516075 Potency 794.3 nM
COc1cccc2c1C(=N)c1c(O)c3c(c(O)c1C2=O)C[C@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 CHEMBL1417445 Potency 794.3 nM
COc1ccc(-c2nc3cnc(N(C)C)nc3n(CCc3ccccc3)c2=O)cc1 CHEMBL1395805 Potency 794.3 nM
O=C1C(Cl)=C(Sc2nnc3c4ccccc4c4ccccc4c3n2)C(=O)c2ccccc21 CHEMBL1317986 Potency 794.3 nM
CCN(CC)C(=O)C1CCN(c2ncnc3c2cnn3-c2ccc(C)cc2C)CC1 CHEMBL1466877 Potency 794.3 nM
O=S(=O)(c1ccccc1)N1CCC2(CCN(c3ccncc3)CC2)CC1 CHEMBL1593589 Potency 794.3 nM
FC(F)(F)c1ccccc1-c1ccc2ncnc(N3CCOCC3)c2c1 CHEMBL1552720 Potency 794.3 nM
COc1ccc(-c2cc(=O)c3c(O)cc(O)cc3o2)cc1 CHEMBL243664 Potency 794.3 nM
O=c1c(-c2ccc(Cl)cc2)nc2cnc(N3CCOCC3)nc2n1CCc1ccccc1 CHEMBL1496664 Potency 794.3 nM
COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 CHEMBL1535932 Potency 794.3 nM
CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3c(NC(=O)CN)cccc3nc2-1 CHEMBL1445386 Potency 794.3 nM
Cc1nc(SCC(=O)Nc2ccc3c(c2)OCO3)c(C#N)c2c1CCCC2 CHEMBL1418583 Potency 794.3 nM
O=c1c(CCc2ccccc2)nc2cncnc2n1Cc1ccc(F)cc1 CHEMBL1555118 Potency 794.3 nM
C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)COC(=O)CCC(=O)O CHEMBL977 Potency 794.3 nM
CN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3 CHEMBL1435422 Potency 794.3 nM
Cc1cccc(CNc2nc(-c3ccoc3)nc3ccccc23)c1 CHEMBL1433464 Potency 794.3 nM
CN(C)[C@@H]1C(O)=C(C(N)=O)C(=O)[C@]2(O)C(O)=C3C(=O)c4c(O)cccc4[C@@](C)(O)[C@H]3[C@H](O)[C@@H]12 CHEMBL1398237 Potency 794.3 nM
CCCCNc1cc(C(=O)O)cc(S(N)(=O)=O)c1Oc1ccccc1 CHEMBL1072 Potency 794.3 nM
COc1ccccc1CNc1ncnc2ccc(-c3ccoc3)cc12 CHEMBL1565927 Potency 794.3 nM
C=C1[C@@H](C)C2[C@H](Cc3ccccc3)NC(=O)[C@]23OC(=O)CC[C@H](O)CCC[C@H](C)C/C=C/[C@H]3[C@@H]1O CHEMBL3207906 Potency 794.3 nM
CCOc1ccc(-n2c(SCc3ccc(C#N)cc3)nnc2-c2cccnc2)cc1 CHEMBL1352377 Potency 794.3 nM
c1ccc2cc(NCNc3ccc4ccccc4c3)ccc2c1 CHEMBL1486304 Potency 794.3 nM
COC(=O)[C@@H]1[C@@H](O)[C@@]2(O)c3c(OC)cc(OC)cc3O[C@@]2(c2ccc(OC)cc2)[C@H]1c1ccccc1 CHEMBL1475040 Potency 794.3 nM
c1ccc(CN2CCN(c3[nH]cnc4c5ccccc5nc3-4)CC2)cc1 CHEMBL1458376 Potency 794.3 nM
CCNc1ncc2nc(-c3cc(F)cc(F)c3)c(=O)n(Cc3cccs3)c2n1 CHEMBL1319312 Potency 794.3 nM
c1ccc2c3nc[nH]c(N4CCSCC4)c-3nc2c1 CHEMBL1575892 Potency 794.3 nM
CCN(CC)C(=O)CSc1nc2ccccc2c(=O)n1CC1CCCCC1 CHEMBL1340201 Potency 794.3 nM
CN1CCN(c2ncnc3ccc(-c4ccoc4)cc23)CC1 CHEMBL1316709 Potency 794.3 nM
C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@@]3(C)[C@H](O)CCC(C)(C)[C@@H]3[C@H](O)[C@H](OC(C)=O)[C@]2(C)O1 CHEMBL1398667 Potency 794.3 nM
CN1CCc2c(sc3ncn4nc(-c5ccccc5O)nc4c23)C1 CHEMBL1499183 Potency 794.3 nM
N#Cc1cccc(NC(=O)N2CCCC3(CCN(S(=O)(=O)c4ccccc4)CC3)C2)c1 CHEMBL1518164 Potency 794.3 nM
COc1ccc2c(c1OC)C(=O)N1c3ccccc3C(=O)N(c3ccccc3F)C21 CHEMBL1518705 Potency 794.3 nM
O=C(CCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 CHEMBL297302 Potency 794.3 nM
CC(C)(O)/C=C\C(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@]2(C)[C@@H]3CC=C4[C@@H](C=C(O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@@]12C CHEMBL1317135 Potency 794.3 nM
CCCCCCCC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C CHEMBL253989 Potency 794.3 nM
C[C@@H]1CC[C@@H]2N(C1)C[C@H]1[C@@](O)([C@H](O)C[C@]3(O)[C@H]4CC[C@H]5[C@]6(O)O[C@]4(C[C@]13O)[C@@]5(C)CC[C@@H]6O)[C@@]2(C)O CHEMBL1528005 Potency 794.3 nM
CCNc1ncc2nc(-c3cccs3)c(=O)n(-c3ccc(OC)cc3)c2n1 CHEMBL1475686 Potency 794.3 nM
C[C@@H](CCc1ccc(O)cc1)NCCc1ccc(O)c(O)c1 CHEMBL1367478 Potency 794.3 nM
C[C@@H](Cc1ccc(O)cc1)NC[C@@H](O)c1cc(O)cc(O)c1 CHEMBL389390 Potency 794.3 nM
CC(CC(=O)O)(CC(=O)O)C(=O)O CHEMBL1606018 Potency 794.3 nM
O=C(COc1ccc(C23CC4CC(CC(C4)C2)C3)cc1)Nc1cc(C(=O)O)ccn1 CHEMBL430393 IC50 800.0 nM
O=C(CCl)Nc1ccc(-c2nc(O)cc(C(F)(F)F)n2)nc1 CHEMBL1271866 IC50 800.0 nM
C[C@H]1[C@H](C)CC[C@]2(C(=O)Nc3nnn[nH]3)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](OC(=O)c6ccccc6)C(C)(C)[C@@H]5CC[C@]43C)[C@H]12 CHEMBL4538270 IC50 800.0 nM
COc1cc(/C=C/c2ccc(OC)c(O)c2)oc(=O)c1 CHEMBL1164430 IC50 810.0 nM
CCOc1ccccc1-n1c(CN2CCN(C)CC2)nc2ccccc2c1=O CHEMBL1836236 IC50 810.0 nM
CCn1c2ccccc2c2cc(NC(=O)c3noc4ccccc34)ccc21 CHEMBL5205347 IC50 810.0 nM
CC1=C[C@@H](O)[C@@H]([C@@H](C)CC[C@@H]2[C@@H](C)[C@@]3(C)CC[C@]2(C)O3)CC1 CHEMBL235553 IC50 820.0 nM
CCOC(=O)c1cccc(NC(=O)/C=C/Oc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 CHEMBL2178416 IC50 820.0 nM
COc1cccc(CC(=O)c2ccc3c(c2OC)C=CC(C)(C)O3)c1 CHEMBL4211498 IC50 820.0 nM
C=Cc1ccc(COc2cccc(OCc3ccccc3/C(=N\OC)C(=O)OC)c2)cc1 CHEMBL4074474 IC50 870.0 nM
COc1c(C(=O)Cc2ccccc2)ccc2c1C=CC(C)(C)O2 CHEMBL4218467 IC50 880.0 nM
O=C(COc1ccc(C23CC4CC(CC(C4)C2)C3)cc1)Nc1cc(C(=O)NCCCn2ccnc2)ccn1 CHEMBL403789 IC50 900.0 nM
NC(=O)c1cncc(NC(=O)COc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 CHEMBL401390 IC50 900.0 nM
O=C(NCCc1ccccc1F)c1ccc(-c2ccccc2)cn1 CHEMBL4556236 IC50 930.0 nM
CO/N=C(/C(=O)OC)c1ccccc1COc1cccc(OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 CHEMBL4101212 IC50 940.0 nM
COc1c(C(=O)Cc2ccccc2O)ccc2c1C=CC(C)(C)O2 CHEMBL4210297 IC50 940.0 nM
O=C(Nc1ccccn1)c1noc2ccccc12 CHEMBL5189187 IC50 940.0 nM