Cn1cc(C2=C(c3cn(CCCSC(=N)N)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL1591531 IC50 0.367 nM
c1ccc2cc(-c3coc4ccc(-c5cn[nH]c5)nc34)ccc2c1 CHEMBL4750420 IC50 16.0 nM
COc1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 CHEMBL4743939 IC50 33.0 nM
Cc1nc(Nc2nc3ccc(-c4cccc(C(=O)Nc5cccc(C(F)(F)F)c5)c4)nc3s2)cc(N2CCNCC2)n1 CHEMBL2148120 Kd 34.0 nM
CC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1N(C)CCN CHEMBL3103192 IC50 40.0 nM
C=C(C)c1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 CHEMBL4743730 IC50 51.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 55.0 nM
c1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 CHEMBL4790030 IC50 62.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 CHEMBL450786 Kd 93.0 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 IC50 100.0 nM
CN(C)C[C@@H]1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1 CHEMBL91829 IC50 100.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1336 IC50 100.0 nM
Cn1cc(-c2ccc3occ(-c4cccc(-c5cc[nH]n5)c4)c3n2)cn1 CHEMBL4762964 IC50 125.0 nM
COCCNC(=O)c1ccc(Oc2sc(C(N)=O)c3c2-c2sncc2CC3)cn1 CHEMBL4066819 Kd 160.0 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 170.0 nM
Cn1cc(-c2ccc3occ(-c4cccc(-c5cn[nH]c5)c4)c3n2)cn1 CHEMBL4789951 IC50 177.0 nM
Cn1cc(-c2ccc3occ(-c4cccc(-c5ccncc5)c4)c3n2)cn1 CHEMBL4754195 IC50 187.0 nM
Cn1cc(-c2cccc(-c3coc4ccc(-c5cnn(C)c5)nc34)c2)cn1 CHEMBL4797457 IC50 209.0 nM
CC1(c2ccc(-c3coc4ccc(-c5cn[nH]c5)nc34)cc2)CC1 CHEMBL4740998 IC50 220.0 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccccc4)c3)cc12 CHEMBL379218 Kd 230.0 nM
Cn1cc(-c2coc3ccc(-c4cn[nH]c4)nc23)cn1 CHEMBL4790791 IC50 235.0 nM
CC(C)(C)c1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 CHEMBL4777288 IC50 248.0 nM
Cn1cc(-c2ccc3occ(-c4cccc(C5CCNCC5)c4)c3n2)cn1 CHEMBL4791451 IC50 264.0 nM
c1ccc(-c2ccc(-c3coc4ccc(-c5cn[nH]c5)nc34)cc2)cc1 CHEMBL4778370 IC50 278.0 nM
CC(C)(C)c1ccc(-c2coc3ccc(-c4cn[nH]n4)nc23)cc1 CHEMBL4778153 IC50 285.0 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 300.0 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL1802358 Kd 320.0 nM
CN1CCC(c2cccc(-c3coc4ccc(-c5cnn(C)c5)nc34)c2)CC1 CHEMBL4741919 IC50 354.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 430.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OC[C@H]3CCCNC3)c21 CHEMBL494089 Kd 510.0 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 Kd 520.0 nM
CC(C)(C)c1ccc(-c2coc3ccc(-c4nn[nH]n4)nc23)cc1 CHEMBL4777533 IC50 545.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 590.0 nM
Cn1cc(C2=C(c3cn(CCCSC(=N)N)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL6291 IC50 621.0 nM
CC(C)Cc1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 CHEMBL4794825 IC50 685.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 820.0 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 Kd 860.0 nM
c1ccc(Cc2ccc(-c3coc4ccc(-c5cn[nH]c5)nc34)cc2)cc1 CHEMBL4789373 IC50 921.0 nM
c1ccc(-c2cnc3c(Nc4ccc(N5CCCCC5)cc4)nccc3n2)cc1 CHEMBL3780758 IC50 922.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 970.0 nM
Cn1cc(C2=C(c3cn(C4CCN(Cc5ccccn5)CC4)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL300138 Kd 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM