NC(=O)c1ccccc1Nc1nc(Nc2ccccc2)ncc1C(F)(F)F CHEMBL1997554 pKi 3.981 nM
c1ccc2cc(-c3coc4ccc(-c5cn[nH]c5)nc34)ccc2c1 CHEMBL4750420 IC50 5.0 nM
COc1ccc2c(NC(=O)Nc3cccc(Br)n3)ccnc2c1 CHEMBL1983932 pKi 6.31 nM
Cc1ccc(Nc2nccc(Nc3ccccc3C(=O)O)n2)cc1F CHEMBL243518 pKi 6.31 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(F)c2)n1 CHEMBL243298 pKi 6.31 nM
Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1987448 pKi 6.31 nM
c1cnc2[nH]cc(-c3ccnc(NC4CCCCC4)n3)c2c1 CHEMBL385478 pKi 6.31 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 7.3 nM
CC(C)(CO)CCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1967662 pKi 7.943 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccccc1 CHEMBL1999931 pKi 7.943 nM
CNCC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1996980 pKi 10.0 nM
CN(C)c1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1 CHEMBL1992363 pKi 12.59 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 12.59 nM
O=[N+]([O-])c1cccc(-c2nnc3ccc(N4CCCCC4)nn23)c1 CHEMBL2003637 pKi 12.59 nM
COc1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 CHEMBL4743939 IC50 15.0 nM
NC1CCC(Nc2nccc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1966628 pKi 15.85 nM
c1ccc(Cn2cc(-c3ccc4[nH]nc(-c5cn(Cc6ccccc6)nn5)c4c3)nn2)cc1 CHEMBL1964288 pKi 15.85 nM
c1cnc2[nH]cc(-c3ccnc(NCC4CCCCC4)n3)c2c1 CHEMBL213207 pKi 15.85 nM
COc1ccccc1C(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1997643 pKi 19.95 nM
O=C(NCc1ccccc1)c1c[nH]n2c(=O)cc(-c3ccncc3)nc12 CHEMBL1974250 pKi 19.95 nM
FC(F)(F)c1ccccc1CNc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1999153 pKi 19.95 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 19.95 nM
CC(=O)Nc1cnc2ccn(-c3cc(NC4CC4)n4ncc(C#N)c4n3)c2c1 CHEMBL2062565 IC50 20.0 nM
Cn1cc(-c2ccc3occ(-c4cccc(-c5ccncc5)c4)c3n2)cn1 CHEMBL4754195 IC50 23.0 nM
OCCCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1970821 pKi 25.12 nM
CNC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2005509 pKi 25.12 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 25.12 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL244378 pKi 25.12 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1Cl CHEMBL1965660 pKi 25.12 nM
NCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1972290 pKi 25.12 nM
COc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1OC CHEMBL1991078 pKi 25.12 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccc(F)cc1 CHEMBL1966204 pKi 25.12 nM
Cn1cc(-c2coc3ccc(-c4cn[nH]c4)nc23)cn1 CHEMBL4790791 IC50 28.0 nM
CC(=O)Nc1ccc2ccn(-c3cc(NC4CC4)n4ncc(C#N)c4n3)c2c1 CHEMBL2062563 IC50 30.0 nM
c1cnc2ncn(-c3cc(Nc4ccc(OCCN5CCCCC5)cn4)ncn3)c2c1 CHEMBL3937369 IC50 30.0 nM
Cn1cc(-c2ccc3occ(-c4cccc(-c5cc[nH]n5)c4)c3n2)cn1 CHEMBL4762964 IC50 30.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 31.0 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(F)c1 CHEMBL2003638 pKi 31.62 nM
COc1cccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)c1 CHEMBL1980435 pKi 31.62 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 31.62 nM
c1ccc(Cn2cc(-c3ccc4[nH]nc(-c5ccccc5)c4c3)nn2)cc1 CHEMBL1982400 pKi 31.62 nM
CN(C)CC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1982271 pKi 31.62 nM
O=C1NC(=O)c2c1c(-c1ccccc1Cl)cc1[nH]c3ccc(O)cc3c21 CHEMBL379975 pKi 31.62 nM
CCNC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1992220 pKi 31.62 nM
CCn1c(C)c(-c2ccnc(Nc3cccc(OC)c3)n2)sc1=O CHEMBL1986263 pKi 39.81 nM
CS(=O)(=O)NCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL2005718 pKi 39.81 nM
CC(C)(CN)CNc1cc(-c2c[nH]c3ncccc23)cc(F)n1 CHEMBL1987261 pKi 39.81 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2c(F)cccc12 CHEMBL1966816 pKi 39.81 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(OC(F)(F)F)c4)c3)cc12 CHEMBL1965836 pKi 39.81 nM
NC(=O)c1ccc(-c2c[nH]c3nccc(Cl)c23)cc1 CHEMBL1982711 pKi 39.81 nM
O=C(O)c1ccccc1Nc1ncnc(Nc2cccc(F)c2)n1 CHEMBL1979933 pKi 39.81 nM
NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1973720 pKi 39.81 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 39.81 nM
CC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1C CHEMBL2409175 IC50 40.0 nM
CC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1N(C)CCN CHEMBL3103192 IC50 40.0 nM
C=C(C)c1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 CHEMBL4743730 IC50 41.0 nM
c1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 CHEMBL4790030 IC50 42.0 nM
CC(=O)Nc1ccc2cnn(-c3cc(NC4CC4)n4ncc(C#N)c4n3)c2c1 CHEMBL2062564 IC50 50.0 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 50.12 nM
NC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1983589 pKi 50.12 nM
N#Cc1cccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)c1 CHEMBL1977128 pKi 50.12 nM
Cc1ccc(NC(=O)Nc2ccc(-c3coc4ncnc(N)c34)cc2)cc1 CHEMBL2005828 pKi 50.12 nM
CCOC(=O)c1c[nH]n2c(=O)cc(-c3ccncc3)nc12 CHEMBL1990708 pKi 50.12 nM
COc1ccc2c(NC(=O)Nc3cccc(C(F)(F)F)n3)ccnc2c1 CHEMBL1982660 pKi 50.12 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(C)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1984162 pKi 50.12 nM
C=CCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1996339 pKi 50.12 nM
CS(=O)(=O)NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1987948 pKi 50.12 nM
CC(=O)Nc1ccc2ccn(-c3cc(NCCCN(C)C)n4ncc(C#N)c4n3)c2c1 CHEMBL2062575 IC50 60.0 nM
COc1ccc(CNc2cc(-c3c[nH]c4ncccc34)cc(F)n2)cc1 CHEMBL1986855 pKi 63.1 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(O)c2)n1 CHEMBL243088 pKi 63.1 nM
Cc1ccc(NC(=O)Nc2ccc(-c3cccc4c3CNC4=O)cc2)cc1C CHEMBL184847 pKi 63.1 nM
COCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1964340 pKi 63.1 nM
COCC(C)Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1998068 pKi 63.1 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1F CHEMBL1981079 pKi 63.1 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 pKi 63.1 nM
CN(C)C1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1969151 pKi 63.1 nM
NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1998432 pKi 63.1 nM
CS(=O)(=O)N(Cc1ccc2[nH]c(=O)c3cccn3c2c1)C1CC1 CHEMBL1978448 pKi 63.1 nM
Clc1cc(-c2c[nH]c3ncccc23)cc(NCc2ccccc2)n1 CHEMBL1969588 pKi 63.1 nM
N#Cc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1 CHEMBL1990162 pKi 63.1 nM
CC1(c2ccc(-c3coc4ccc(-c5cn[nH]c5)nc34)cc2)CC1 CHEMBL4740998 IC50 68.0 nM
Cn1cc(-c2cccc(-c3coc4ccc(-c5cnn(C)c5)nc34)c2)cn1 CHEMBL4797457 IC50 70.0 nM
O=C1NC(=O)/C(=C\c2c[nH]c(=O)c(-c3ccc(N4CCNCC4)nc3)c2)S1 CHEMBL4587433 IC50 74.0 nM
Cc1cccc(-c2[nH]c(-c3ccnc(N)n3)cc2C(N)=O)c1C CHEMBL1964290 pKi 79.43 nM
O=c1cc(-c2ccncc2)nc(NC2CCCCC2)[nH]1 CHEMBL1958401 pKi 79.43 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccc(Cl)cc1 CHEMBL1987073 pKi 79.43 nM
OC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1991674 pKi 79.43 nM
CS(=O)(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1980562 pKi 79.43 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 79.43 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL1970903 pKi 79.43 nM
CCN(CC)CCCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)csc12 CHEMBL1996649 pKi 79.43 nM
OCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1989006 pKi 79.43 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 92.0 nM
CCCCNc1c(-c2ccc3[nH]ncc3c2)nc2ncccn12 CHEMBL1682554 pKi 100.0 nM
CN(C)C1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1965702 pKi 100.0 nM
CC(C)CNC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2006456 pKi 100.0 nM
CCN(CC)CCCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL1999414 pKi 100.0 nM
CC(=O)NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1980178 pKi 100.0 nM
COc1cc(C=C2SC(=S)NC2=O)ccc1O CHEMBL1973098 pKi 100.0 nM
Cn1cc(-c2ccccc2)c2nc(-c3ccncc3)cc(=O)n21 CHEMBL1986767 pKi 100.0 nM
CCCC(=O)Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1998470 pKi 100.0 nM
c1ccc(CNc2cc(-c3c[nH]c4ncccc34)ncn2)cc1 CHEMBL2002346 pKi 100.0 nM
COc1cc(OC)cc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)c1 CHEMBL2002613 pKi 100.0 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCCCC2)n1 CHEMBL2006439 pKi 100.0 nM
COc1cc(C=C(C#N)c2nc3ccccc3[nH]2)c(Br)cc1O CHEMBL1994241 pKi 100.0 nM
Cc1nc2c(sc3c(Br)ccc(Cl)c32)c(=O)o1 CHEMBL1974702 pKi 100.0 nM
CCCCOc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1996817 pKi 100.0 nM
COc1cc(C=C(C#N)c2nc3cc(C)ccc3[nH]2)c(Br)cc1O CHEMBL2000345 pKi 100.0 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cc(F)ccc1F CHEMBL1995811 pKi 100.0 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 IC50 100.0 nM
CN(C)C[C@@H]1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1 CHEMBL91829 IC50 100.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1336 IC50 100.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 CHEMBL450786 IC50 100.0 nM
Cn1cc(-c2ccc3occ(-c4cccc(-c5cn[nH]c5)c4)c3n2)cn1 CHEMBL4789951 IC50 102.0 nM
CC(C)(C)c1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 CHEMBL4777288 IC50 119.0 nM
CC(C)(C)c1ccc(-c2coc3ccc(-c4cn[nH]n4)nc23)cc1 CHEMBL4778153 IC50 123.0 nM
CC(C)(CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1)CNS(C)(=O)=O CHEMBL1971172 pKi 125.89 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(OC(F)F)cc5)cc4)csc23)cn1 CHEMBL1988387 pKi 125.89 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 125.89 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(Cl)c1 CHEMBL1983595 pKi 125.89 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCOCC2)n1 CHEMBL1980253 pKi 125.89 nM
NC1CCCCC1Nc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL1994438 pKi 125.89 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)cc1C CHEMBL2000335 pKi 125.89 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL1967531 pKi 125.89 nM
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1973540 pKi 125.89 nM
CC(C)(O)CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL2005387 pKi 125.89 nM
COc1cccc(C(C)NC(=O)N2CC=C(c3c[nH]c4ncccc34)CC2)c1 CHEMBL1965845 pKi 125.89 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccc(Cl)c(Cl)c4)c3)cc12 CHEMBL1991063 pKi 125.89 nM
CC(C)(CN)CNc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL1968930 pKi 125.89 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 146.0 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(C=Cc3ccccc3)n2)n[nH]1 CHEMBL1983923 pKi 158.49 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 pKi 158.49 nM
CC(C)(CN)CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1985723 pKi 158.49 nM
CCN(CC)CCNC(=O)C=Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL2004716 pKi 158.49 nM
Cc1cccc(CNc2cc(-c3c[nH]c4ncccc34)ncn2)c1 CHEMBL1995932 pKi 158.49 nM
CN(Cc1ccccc1)c1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1969920 pKi 158.49 nM
COc1ccc(C=C2SC(=Nc3ccccc3)NC2=O)cc1O CHEMBL2000354 pKi 158.49 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3ccc4nccnc4c3N)cc2)c1 CHEMBL1971649 pKi 158.49 nM
OC1CCCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1976936 pKi 158.49 nM
CS(=O)(=O)NC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2005216 pKi 158.49 nM
O=c1nc(-c2ccc3[nH]ncc3c2)cc(-c2ccccc2)[nH]1 CHEMBL526133 pKi 158.49 nM
Cc1ccc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1988075 pKi 158.49 nM
O=C(O)c1ccccc1Nc1ncnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL1986666 pKi 158.49 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1977223 pKi 158.49 nM
c1ccc(-c2ccc(-c3coc4ccc(-c5cn[nH]c5)nc34)cc2)cc1 CHEMBL4778370 IC50 172.0 nM
Cn1cc(-c2ccc3occ(-c4cccc(C5CCNCC5)c4)c3n2)cn1 CHEMBL4791451 IC50 179.0 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(-c4ccccc4)c3n2)c1 CHEMBL1988163 pKi 199.53 nM
O=c1cc(-c2ccc(F)cc2)[nH]c2c(-c3ccc(F)cc3)cnn12 CHEMBL2004443 pKi 199.53 nM
CCCCNc1cc(-c2c[nH]c3ncccc23)ncn1 CHEMBL1968459 pKi 199.53 nM
Cc1ccc(C(=O)Nc2c(C(N)=O)sc3ccc(Cl)c(Cl)c23)cc1 CHEMBL1965131 pKi 199.53 nM
O=C1NCCc2[nH]c(-c3ccncc3)cc21 CHEMBL225519 pKi 199.53 nM
O=c1[nH]cnc2c1sc1c(Cl)ccc(Cl)c12 CHEMBL583144 pKi 199.53 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 pKi 199.53 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(-c3c(C)sc4ncnc(N)c34)cc2)c1 CHEMBL371206 pKi 199.53 nM
CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL1084546 pKi 199.53 nM
NC(=O)c1ccc(Nc2ncnc3[nH]cc(-c4ccccc4)c23)cc1 CHEMBL1975440 pKi 199.53 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 pKi 199.53 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccccc4)c3)cc12 CHEMBL379218 Kd 220.0 nM
CC(=O)Nc1c(C(N)=O)sc2ccc(Cl)c(Cl)c12 CHEMBL1973142 pKi 251.19 nM
O=C1NCCc2[nH]c(-c3ccnc(C=Cc4ccccc4)c3)cc21 CHEMBL1997129 pKi 251.19 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cnc4c(-c5cnn(C)c5)cnn4c3N)cc2)c1 CHEMBL508928 pKi 251.19 nM
COCCN(CCOC)c1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1985654 pKi 251.19 nM
O=c1nc(-c2cc3c(Oc4ccc(I)cc4)cncc3s2)[nH]o1 CHEMBL497151 pKi 251.19 nM
Nc1ncc(-c2ccoc2)c2scc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)c12 CHEMBL1965570 pKi 251.19 nM
c1cnc2nc(-c3ccc4[nH]ncc4c3)c(NC3CCCCC3)n2c1 CHEMBL1682552 pKi 251.19 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CCO)c5)cnc(N)c34)cc2F)c1 CHEMBL1986851 pKi 251.19 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 251.19 nM
O=C(NN=Cc1ccc(O)cc1O)Nc1cccc2nsnc12 CHEMBL1999811 pKi 251.19 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc32)c1C CHEMBL1990885 pKi 251.19 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccccc4)c3)cc12 CHEMBL2002726 pKi 251.19 nM
Nc1nnc(-c2cc3c(Oc4ccc(Cl)cc4)cncc3s2)o1 CHEMBL1994830 pKi 251.19 nM
CN1CCC(c2cccc(-c3coc4ccc(-c5cnn(C)c5)nc34)c2)CC1 CHEMBL4741919 IC50 260.0 nM
Oc1cccc(-c2nc(N3CCOCC3)c3oc4ncccc4c3n2)c1 CHEMBL573339 Kd 290.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 300.0 nM
O=C([O-])c1ccc2c(c1)cc(Cl)c1ccncc12 CHEMBL4874005 IC50 300.0 nM
O=C([O-])c1ccc2c(c1)cc(Nc1cccc(Cl)c1)c1ccncc12 CHEMBL4864298 IC50 300.0 nM
O=C([O-])c1ccc2c(c1)cc(Nc1ccc(Cl)cc1)c1ccncc12 CHEMBL4869607 IC50 300.0 nM
Cc1cc2cc(C(=O)[O-])ccc2c2cnccc12 CHEMBL4855827 IC50 300.0 nM
Nc1ccc(-c2cc3cc(C(=O)[O-])ccc3c3cnccc23)cn1 CHEMBL4849181 IC50 300.0 nM
O=C([O-])c1ccc2c(c1)cc(NC1CCCCC1)c1ccncc12 CHEMBL4871526 IC50 300.0 nM
O=C([O-])c1ccc2c(c1)cc(NC1CCCC1)c1ccncc12 CHEMBL4855218 IC50 300.0 nM
CCC(C)Nc1cc2cc(C(=O)[O-])ccc2c2cnccc12 CHEMBL4856136 IC50 300.0 nM
O=C([O-])c1ccc2c(c1)cc(NC1CCC1)c1ccncc12 CHEMBL4856667 IC50 300.0 nM
O=C([O-])c1ccc2c(c1)cc(N1CCCCC1)c1ccncc12 CHEMBL4862671 IC50 300.0 nM
CC(C)Nc1cc2cc(C(=O)[O-])ccc2c2cnccc12 CHEMBL4871816 IC50 300.0 nM
O=C([O-])c1ccc2c(c1)cc(Br)c1ccnc(Cl)c12 CHEMBL4870585 IC50 300.0 nM
O=C([O-])c1ccc2c(c1)cc([N+](=O)[O-])c1ccncc12 CHEMBL4867336 IC50 300.0 nM
N#Cc1cc2cc(C(=O)[O-])ccc2c2cnccc12 CHEMBL4850936 IC50 300.0 nM
O=C([O-])c1ccc2c(c1)cc(C1CC1)c1ccncc12 CHEMBL4862119 IC50 300.0 nM
NC(=O)c1ccc2c(c1)cc(Br)c1ccnc(N)c12 CHEMBL4876205 IC50 300.0 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 316.23 nM
Nc1ncnc2onc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)c12 CHEMBL213505 pKi 316.23 nM
CC(C)(Nc1nccc(-c2c[nH]c3ncccc23)n1)c1ccccc1 CHEMBL1999279 pKi 316.23 nM
S=c1[nH]nc2c3c4c(sc3n3c(=S)[nH]nc3n12)CCC4 CHEMBL1969537 pKi 316.23 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl CHEMBL458997 pKi 316.23 nM
Cn1cc(-c2cnn3c(N)c(-c4ccc(NC(=O)Nc5cccc(C(F)(F)F)c5)cc4)cnc23)cn1 CHEMBL1988717 pKi 316.23 nM
Cc1ccccc1NC(=O)Nc1ccc(-c2coc3ncnc(N)c23)cc1 CHEMBL1984586 pKi 316.23 nM
COc1ccc(NC(=O)Nc2ccc(-c3cccc4onc(N)c34)cc2)cc1Cl CHEMBL272453 pKi 316.23 nM
COc1ccc(-c2ccc(NC(=O)Nc3ccc(F)c(C)c3)cc2)c2c(N)noc12 CHEMBL1979093 pKi 316.23 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)csc12 CHEMBL2005631 pKi 316.23 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5426285 IC50 317.0 nM
O=C1c2c(Br)c(Br)c(Br)c(Br)c2C(=O)N1c1ncc[nH]1 CHEMBL4795076 IC50 330.0 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 350.0 nM
CC(C)(C)c1ccc(-c2coc3ccc(-c4nn[nH]n4)nc23)cc1 CHEMBL4777533 IC50 357.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 370.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OC[C@H]3CCCNC3)c21 CHEMBL494089 Kd 390.0 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1998585 pKi 398.11 nM
O=C1CCCN1Cc1ccc2c(c1)[nH]c(=O)c1cccn12 CHEMBL539474 pKi 398.11 nM
CC(C)(C)Oc1cc(-c2ccncc2)cc2[nH]nc(N)c12 CHEMBL2002456 pKi 398.11 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)cc1)CCN2 CHEMBL411903 pKi 398.11 nM
Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)cncc21 CHEMBL1964692 pKi 398.11 nM
NC(=O)c1cc2c(-c3ccc(F)cc3)cncc2s1 CHEMBL1974310 pKi 398.11 nM
CCCCNc1cc(-c2ccncc2)cc2[nH]nc(N)c12 CHEMBL1983157 pKi 398.11 nM
CC(C)Nc1c(-c2ccc3[nH]ncc3c2)nc2ncccn12 CHEMBL1682553 pKi 398.11 nM
Cc1cccc(CNc2cc(-c3c[nH]c4ncccc34)cc(Cl)n2)c1C CHEMBL1988331 pKi 398.11 nM
CN(C)CC(=O)NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1995712 pKi 398.11 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)cc1 CHEMBL1982466 pKi 398.11 nM
c1ccc(Cc2ccc(-c3coc4ccc(-c5cn[nH]c5)nc34)cc2)cc1 CHEMBL4789373 IC50 484.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 Kd 500.0 nM
CC(C)Cc1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 CHEMBL4794825 IC50 501.0 nM
CNC(=O)c1cc2c(-c3ccccc3F)n[nH]c2s1 CHEMBL1977681 pKi 501.19 nM
NC(=O)c1sc2ccc(Cl)c(Cl)c2c1NC(=O)c1ccc(Cl)cc1 CHEMBL2003271 pKi 501.19 nM
O=c1[nH]c2sc3c(c2c2nc(-c4ccncc4)nn12)CCCC3 CHEMBL1966808 pKi 501.19 nM
O=C(O)c1ccccc1Nc1ncnc(Nc2ccc(F)cc2)n1 CHEMBL1992231 pKi 501.19 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 501.19 nM
COc1ccc(-c2cc3nccn3c(Nc3ncccc3C(N)=O)n2)cc1OC CHEMBL1190711 pKi 501.19 nM
O=c1cc(-c2cccc(F)c2)[nH]c2c(-c3ccc(F)cc3)cnn12 CHEMBL2004156 pKi 501.19 nM
Clc1cc(-c2c[nH]c3ncccc23)ncn1 CHEMBL1972988 pKi 501.19 nM
CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL521851 Kd 520.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 559.0 nM
CC(=O)Nc1ccc2c(c1)c(-c1cc(NC3CC3)n3ncc(C#N)c3n1)cn2CCC(=O)O CHEMBL2062585 IC50 570.0 nM
O=C1Nc2ccccc2Nc2cc(-c3ccncc3F)ccc21 CHEMBL1989293 pKi 630.96 nM
COc1cc(C=C2SC(=O)NC2=O)ccc1O CHEMBL2003286 pKi 630.96 nM
Cc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccc(F)cc3)cc12 CHEMBL1972339 pKi 630.96 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 630.96 nM
O=c1cc(-c2ccncc2)nc(NCc2cc(F)cc(F)c2)[nH]1 CHEMBL2003682 pKi 630.96 nM
Cc1cc(Cl)ccc1NC(=S)NNC(=O)C(O)(c1ccccc1)c1ccccc1 CHEMBL1988173 pKi 630.96 nM
CC(C)=C(C)c1cccc2c(CCCOc3cccc(Cl)c3Cl)c(C(=O)O)[nH]c12 CHEMBL1982980 pKi 630.96 nM
NCCC(C(=O)Nc1ccc2[nH]ncc2c1)c1ccc(Cl)c(Cl)c1 CHEMBL1998121 pKi 630.96 nM
Clc1cc(NC2CCCCC2)nc(-c2c[nH]c3ncccc23)n1 CHEMBL1997846 pKi 630.96 nM
Cc1ccc(Nc2nc3ccc([N+](=O)[O-])cc3[nH]2)nc1 CHEMBL1992937 pKi 630.96 nM
c1n[nH]cc1-c1ccc2occ(-c3ccc(C4CCCCC4)cc3)c2n1 CHEMBL4777540 IC50 654.0 nM
Cn1cc(C2=C(c3cn(C4CCN(Cc5ccccn5)CC4)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL300138 Kd 720.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 790.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)c1 CHEMBL1967116 pKi 794.33 nM
NC(=O)c1cc2c(Oc3cccc(F)c3)cncc2s1 CHEMBL1964777 pKi 794.33 nM
Cc1cc(C)c(C)c(OCCCc2c(C(=O)O)[nH]c3c(-c4ccccc4C)cccc23)c1 CHEMBL1990821 pKi 794.33 nM
CCn1c(-c2nonc2N)nc2cnc(Oc3cccc(NC(=O)c4ccc(OCCN5CCOCC5)cc4)c3)cc21 CHEMBL220241 pKi 794.33 nM
CCCCOc1cc(-c2ccncc2)cc2[nH]nc(N)c12 CHEMBL1996447 pKi 794.33 nM
NCCCOc1cc2c(c(-c3ccc(Nc4nc5ccccc5o4)cc3)c1)CNC2=O CHEMBL1975490 pKi 794.33 nM
Cc1ccc2nccc(NC(=O)Nc3cccc(C(F)(F)F)n3)c2c1 CHEMBL1964444 pKi 794.33 nM
Cc1cccc(Nc2nc(NC3CCCCC3N)cnc2C(N)=O)c1 CHEMBL1974328 pKi 794.33 nM
CCN1CCN(CCCC(=O)Nc2n[nH]c3nnc(-c4cccc(F)c4F)cc23)CC1 CHEMBL1992740 pKi 794.33 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CC(C)(C)N)cnc(N)c34)cc2)c1 CHEMBL1979577 pKi 794.33 nM
COc1cccc(CNC(=O)c2cc3c(-c4ccccc4)n[nH]c3s2)c1 CHEMBL1987009 pKi 794.33 nM
N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL1789941 Kd 1000.0 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 Kd 1000.0 nM
OCCC(Nc1nc2ccc(-c3ccncc3)cc2s1)c1ccccc1 CHEMBL1982122 pKi 1000.0 nM
CC(C)OC1=NNC(=O)C1=Cc1c[nH]c2ccccc12 CHEMBL1989029 pKi 1000.0 nM
COc1ccc2c(c1)C(=Cc1c[nH]cn1)C(=O)N2 CHEMBL2002649 pKi 1000.0 nM
Cc1nc2ccccn2c1-c1csc(Nc2ccc(O)cc2)n1 CHEMBL513846 pKi 1000.0 nM
Nc1ncnc2c1sc1ncnc(N)c12 CHEMBL1976090 pKi 1000.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCCNS(C)(=O)=O)c3)cc12 CHEMBL1967704 pKi 1000.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN)cnc(N)c34)cc2)c1 CHEMBL1965988 pKi 1000.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN(C)C)cnc(N)c34)cc2)c1 CHEMBL1979883 pKi 1000.0 nM
Fc1cccc(-c2c[nH]c3ncccc23)c1 CHEMBL1993648 pKi 1000.0 nM
c1ccc(Cn2nnc(-c3ccc4[nH]ncc4c3)c2-c2ccccc2)cc1 CHEMBL1969473 pKi 1000.0 nM
Cc1ccccc1-c1c(C(=O)O)n(CCCOc2cccc3ccccc23)c2ccccc12 CHEMBL1987793 pKi 1000.0 nM
COc1ccc(-c2ccc(NC(=O)Nc3cc(F)cc(F)c3)cc2)c2c(N)noc12 CHEMBL1969190 pKi 1000.0 nM
CCN1CCN(c2ccc(Nc3nccc(-c4c(-c5cccc(C(=O)Nc6ccccc6F)c5)nc5ccccn45)n3)cc2)CC1 CHEMBL1981725 pKi 1000.0 nM
Brc1cnc2[nH]cc(-c3ccccc3)c2c1 CHEMBL1992634 pKi 1000.0 nM
Nc1ncnc2scc(C(=O)Nc3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL1988594 pKi 1000.0 nM
O=C([O-])c1ccc2c(ccc3ccncc32)c1 CHEMBL4852889 IC50 1000.0 nM
O=C([O-])c1ccc2c(c1)cc(-c1ccc(Cl)cc1)c1ccncc12 CHEMBL4878788 IC50 1000.0 nM
O=C([O-])c1ccc2c(c1)cc(-c1cccnc1)c1ccncc12 CHEMBL4855640 IC50 1000.0 nM
O=C([O-])c1ccc2c(c1)cc(-c1ccncc1)c1ccncc12 CHEMBL4858891 IC50 1000.0 nM
O=C([O-])c1ccc2c(c1)cc(-c1cc[nH]n1)c1ccncc12 CHEMBL4856281 IC50 1000.0 nM
O=C(O)c1ccc2c(c1)cc(N[C@@H]1CCCNC1)c1ccncc12 CHEMBL4855950 IC50 1000.0 nM
CC[C@H](C)Nc1cc2cc(C(=O)O)ccc2c2cnccc12 CHEMBL4867159 IC50 1000.0 nM
O=C([O-])c1ccc2c(ccc3ccnc(Cl)c32)c1 CHEMBL4848434 IC50 1000.0 nM
CN(C)c1nccc2c(Br)cc3cc(C(=O)[O-])ccc3c12 CHEMBL4879266 IC50 1000.0 nM
O=C([O-])c1ccc2c(c1)cc(Br)c1ccnc(NC3CC3)c12 CHEMBL4846302 IC50 1000.0 nM
CNc1nccc2c(Br)cc3cc(C(=O)[O-])ccc3c12 CHEMBL4856868 IC50 1000.0 nM
COc1nccc2c(Br)cc3cc(C(=O)[O-])ccc3c12 CHEMBL4870359 IC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM