O=C(Nc1ccc(N2CCCC2=O)cc1)c1cnc(-c2ccccn2)nc1 CHEMBL4238290 Kd 0.14 nM
O=C(NC1CCN(CC(F)(F)F)CC1)c1ccc(-c2ccccc2)nc1 CHEMBL2035650 IC50 0.2 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc3nc(C4CC4)ccc3c2)CC1 CHEMBL5285108 Kd 0.24 nM
O=C(Nc1ccc(N2CCC(C(=O)N3CCOCC3)CC2)cc1)c1cnc(Oc2ccccc2)nc1 CHEMBL4238186 Kd 0.37 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc3cc(OC(F)F)ccc3c2)CC1 CHEMBL4473072 Kd 0.5 nM
O=C(NCCN1CCOCC1)c1ccc(-c2nccc3ccccc23)cc1 CHEMBL2035651 IC50 2.34 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc3nc(N4CCC4)c(Cl)cc3c2)CC1 CHEMBL5272869 IC50 2.4 nM
COc1ccc2c(n1)c(C)cn2NC(=O)c1cnc(-c2ccccn2)nc1C CHEMBL4247050 IC50 3.0 nM
C[C@H]1CCN1c1nc2ncc(C(=O)N[C@H]3C[C@H](C(C)(C)O)C3)cc2cc1Cl CHEMBL5289520 IC50 3.1 nM
C[C@H]1CCN1c1nc2ncc(C(=O)N[C@H]3CC[C@H](C(C)(C)O)CC3)cc2cc1Cl CHEMBL5289730 IC50 3.8 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc3cc(N4CCC4)ncc3c2)CC1 CHEMBL5279860 IC50 3.9 nM
CC(C)(O)[C@H]1CC2(C[C@H](NC(=O)c3cnc4nc(C5CC5)ccc4c3)C2)C1 CHEMBL5275536 IC50 3.9 nM
CC(C)(O)[C@H]1C[C@H](NC(=O)c2cnc3nc(C4CC4)c(Cl)cc3c2)C1 CHEMBL5282861 IC50 3.9 nM
Fc1cccc(-c2ncc(-c3cnc(-c4ccccc4)nc3)[nH]2)c1 CHEMBL3925567 IC50 4.0 nM
C[C@H]1CCN1c1ccc2cc(C(=O)N[C@H]3CC[C@H](C(C)(C)O)CC3)cnc2n1 CHEMBL5285125 IC50 4.4 nM
C[C@H]1CCN1c1nc2ncc(C(=O)N[C@H]3CC[C@](C)(O)CC3)cc2cc1Cl CHEMBL5279371 IC50 4.6 nM
O=C(N[C@H]1CCNC1=O)c1cnc2nc(C3CC3)c(Cl)cc2c1 CHEMBL5266142 IC50 4.6 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc3nc(C4CC4)c(Cl)cc3c2)CC1 CHEMBL5269778 IC50 4.7 nM
C[C@H]1CCN1c1cc2ncc(C(=O)N[C@H]3CC[C@H](C(C)(C)O)CC3)cc2cn1 CHEMBL5269001 IC50 4.8 nM
CC(C)(O)C1CC2(CC(NC(=O)c3cnc4nc(C5CC5)ccc4c3)C2)C1 CHEMBL5279720 IC50 4.9 nM
C[C@H]1CCN1c1nc2ncc(C(=O)N[C@H]3C[C@](C)(O)C3)cc2cc1Cl CHEMBL5278680 IC50 5.0 nM
C[C@H]1CCN1c1nc2ncc(C(=O)N[C@H]3C[C@@](C)(O)C3)cc2cc1Cl CHEMBL5266618 IC50 5.0 nM
C[C@H]1CCN1c1nc2ncc(C(=O)N[C@H]3CCNC3=O)cc2cc1Cl CHEMBL5267588 IC50 5.1 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc3nc(N4CCC4)ccc3c2)CC1 CHEMBL5283521 IC50 5.3 nM
CC(C)(O)c1nc(-c2cccc(-c3ncc(-c4cnc(-c5ccccc5)nc4)[nH]3)c2)no1 CHEMBL4752221 IC50 5.88 nM
c1ccc(CN2CCC(c3ncc(-c4cnc(-c5ccccc5)nc4)[nH]3)CC2)cc1 CHEMBL3982640 IC50 6.0 nM
Cc1nc(-c2ccccn2)ncc1C(=O)Nn1cc(C)c2nc(F)ccc21 CHEMBL4241885 IC50 6.0 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2ccc3c(cnn3-c3cccc(F)c3)c2)CC1 CHEMBL4866146 IC50 6.0 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc3nc(C4CC4)ncc3c2)CC1 CHEMBL5282228 IC50 6.4 nM
C[C@]1(O)C[C@H](NC(=O)c2cnc3nc(C4CC4)c(Cl)cc3c2)C1 CHEMBL5273656 IC50 6.4 nM
COc1nc2ncc(C(=O)N[C@H]3CC[C@H](C(C)(C)O)CC3)cc2cc1Cl CHEMBL5277213 IC50 6.6 nM
Cc1nc(-c2ccccn2)ncc1C(=O)Nn1cc(C)c2cc(F)ccc21 CHEMBL3181890 IC50 7.0 nM
C[C@]1(O)C[C@@H](NC(=O)c2cnc3nc(C4CC4)c(Cl)cc3c2)C1 CHEMBL5268479 IC50 7.1 nM
O=C(NCc1ccccc1)c1cnc(-c2ccccn2)nc1 CHEMBL4740750 IC50 7.14 nM
CC(C)(O)c1nc(-c2cccc(CNC(=O)c3cnc(-c4ccccc4)nc3)c2)no1 CHEMBL4753053 IC50 7.18 nM
CC(C)(O)c1nc(-c2cccc(CNC(=O)c3cnc(-c4ccccn4)nc3)c2)no1 CHEMBL3963991 IC50 7.48 nM
Cc1nc(-c2ncccn2)ncc1C(=O)Nn1ccc2c(C(F)(F)F)cccc21 CHEMBL4250602 IC50 8.0 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2ccc3nc(-c4ccccc4F)cn3c2)CC1 CHEMBL4870703 IC50 8.0 nM
COc1ccc2cc(C(=O)NC3CC4(C3)CC(C(C)(C)O)C4)cnc2c1 CHEMBL4439454 IC50 8.2 nM
Cc1cc2ccccc2c(-c2ccc(C(=O)NCCN3CCOCC3)cc2)n1 CHEMBL2035653 IC50 8.26 nM
CC(C)c1ccc2cc(C(=O)N[C@H]3CC[C@H](C(C)(C)O)CC3)cnc2n1 CHEMBL5289474 IC50 8.5 nM
c1ccc(-c2ncc(-c3cnc(-c4ccccc4)[nH]3)cn2)cc1 CHEMBL3978032 IC50 8.88 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2ccc3nc(-c4ccccc4)cn3c2)CC1 CHEMBL4864805 IC50 9.0 nM
O=C(NC1CCN(CC(F)(F)F)CC1)c1ccc(-c2cccc(F)c2)nc1 CHEMBL1233897 Kd 9.5 nM
CNS(=O)(=O)c1cccc(CNC(=O)c2cnc(-c3cccc(F)c3)nc2C)c1 CHEMBL4242281 IC50 9.5 nM
COc1ccc2cc(C(=O)NC3CCN(c4nccs4)CC3)cnc2c1 CHEMBL4452633 IC50 9.7 nM
Cc1nc(-c2ccccn2)ncc1C(=O)Nn1ccc2c(C(F)(F)F)cccc21 CHEMBL4239352 IC50 10.0 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2ccc3c(ccn3-c3cccc(F)c3)c2)CC1 CHEMBL4868339 IC50 10.0 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc3nc(C4CCC4)ccc3c2)CC1 CHEMBL5288532 IC50 10.0 nM
C[C@H](NC(=O)c1cnc(-c2ccccn2)nc1)c1cccc(-c2noc(C(C)(C)O)n2)c1 CHEMBL3896080 IC50 11.0 nM
CC(N[C@H]1CC[C@H](NC(=O)c2cnc3nc(C4CC4)ccc3c2)CC1)C(F)F CHEMBL5290809 IC50 11.0 nM
O=C(NCc1ccccc1)c1cnc(-c2ccccc2)nc1 CHEMBL4786374 IC50 11.7 nM
COc1cccc(-c2ccc(C(=O)NC3CCN(CC(F)(F)F)CC3)cn2)c1 CHEMBL3425948 Kd 12.0 nM
CC(C)(O)[C@@H]1CC[C@@H](NC(=O)c2ccc3nc(-c4ccccc4F)cn3c2)CO1 CHEMBL4859922 IC50 12.0 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc3cc(N4CC(F)C4)ncc3c2)CC1 CHEMBL5278530 IC50 12.0 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc3nc(N4CCC4)ncc3c2)CC1 CHEMBL5275367 IC50 12.0 nM
O=C(N[C@H]1CCNC1=O)c1cnc2cc(N3CCC3)ncc2c1 CHEMBL5284902 IC50 12.0 nM
c1ccc(-c2ncc(-c3cnc(-c4cccnc4)[nH]3)cn2)cc1 CHEMBL3922118 IC50 12.5 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc3nc(N4CC(F)C4)ccc3c2)CC1 CHEMBL5283710 IC50 13.0 nM
COc1ccc2cc(C(=O)N[C@H]3CC[C@H](NCC(F)(F)F)CC3)cnc2c1 CHEMBL4454901 IC50 14.0 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc3cc(C4CC4)ncc3c2)CC1 CHEMBL5271855 IC50 14.0 nM
O=C(N[C@H]1CC[C@H](N2CC(F)(F)C2)CC1)c1cnc2cc(C3CC3)ncc2c1 CHEMBL5288898 IC50 14.0 nM
O=C(N[C@H]1CC[C@H](N2CC(F)(F)C2)CC1)c1cnc2nc(C3CC3)ccc2c1 CHEMBL5266974 IC50 14.0 nM
CC1C=CC=C1C(=O)N1CCN(C(=O)NC2CCN(c3ccc(CCn4ccnn4)cc3)CC2)CC1 CHEMBL3698263 IC50 15.0 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc3cc(OC(F)(F)F)ccc3c2)CC1 CHEMBL4526974 IC50 15.0 nM
COc1ccc2cc(C(=O)NC3CCc4ccccc43)cnc2c1 CHEMBL4530713 IC50 16.0 nM
COc1ccc2cc(C(=O)Nc3cc(-c4ccccc4)[nH]n3)cnc2c1 CHEMBL4443093 IC50 17.0 nM
CC(C)(O)[C@]12C[C@@](NC(=O)c3cnc4nc(C5CC5)ccc4c3)(C1)C2 CHEMBL5280247 IC50 17.0 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2ccc3nc(-c4cccc(F)c4)cn3c2)CC1 CHEMBL4873385 IC50 18.0 nM
Cn1nnnc1N1CCC(NC(=O)c2cnc3cc(OC(F)F)ccc3c2)CC1 CHEMBL4458862 IC50 20.0 nM
CC(C)(O)[C@H]1CC[C@H](CNC(=O)N2CCc3c(cnn3-c3cccc(F)c3)C2)CC1 CHEMBL4874001 IC50 20.0 nM
c1ccc(-c2ncc(-c3cc[nH]n3)s2)cc1 CHEMBL261777 IC50 21.0 nM
CC(C)(O)c1nc(-c2ccc(CNC(=O)c3cnc(-c4ccccn4)nc3)cc2)no1 CHEMBL3425949 Kd 23.0 nM
C(=C/c1ncc(-c2cnc(-c3ccccc3)nc2)[nH]1)\c1cccnc1 CHEMBL3978802 IC50 23.0 nM
CC(C)(CO)NS(=O)(=O)c1cccc(CNC(=O)c2cnc(-c3cccc(F)c3)nc2)c1 CHEMBL4244590 IC50 23.0 nM
COc1ccc2cc(C(=O)Nc3cc(C4CC4)[nH]n3)cnc2c1 CHEMBL4467696 IC50 23.0 nM
CON(C)C(=O)c1[nH]c(C)c(-c2nc3cc(C(=O)c4ccccc4)ccc3[nH]2)c1C CHEMBL4747168 IC50 23.0 nM
CC(C)(O)c1nc(-c2cccc(-c3ncc(-c4ccc(-c5ccccn5)nc4)[nH]3)c2)no1 CHEMBL4783535 IC50 23.41 nM
COc1ccc2cc(C(=O)N[C@H]3CC[C@H](C(C)(C)O)CC3)cnc2c1 CHEMBL4483631 IC50 25.0 nM
O=C(CCc1cccnc1)Nc1cncc(-c2cccc3[nH]ccc23)c1 CHEMBL3425953 IC50 26.0 nM
C[C@@H](NC(=O)c1cnc(-c2ccccn2)nc1)c1cccc(-c2noc(C(C)(C)O)n2)c1 CHEMBL4112172 IC50 26.0 nM
COc1ccc2cc(C(=O)N[C@H]3CC[C@H](OCC(C)(C)O)CC3)cnc2c1 CHEMBL4463046 IC50 26.0 nM
CC1C=CC=C1C(=O)N1CCN(C(=O)NC2CCN(c3ccc(C(=O)NCCN4CCOCC4)cc3)CC2)CC1 CHEMBL3698259 IC50 27.0 nM
CC1C=CC=C1C(=O)N1CCN(C(=O)NC2CCN(c3ccc(CCCn4ccnn4)cc3)CC2)CC1 CHEMBL3698265 IC50 27.0 nM
CC(C)(O)c1nc(-c2cccc(CNC(=O)c3ccc(-c4ccccc4)nc3)c2)no1 CHEMBL4744566 IC50 27.7 nM
CC(C)(O)[C@@H]1CC[C@@H](NC(=O)c2ccc3nc(-c4ccccc4)cn3c2)CO1 CHEMBL4847268 IC50 30.0 nM
COc1ccc2cc(C(=O)N[C@H]3CC[C@H](C(C)(C)O)CC3)cnc2n1 CHEMBL5274762 IC50 30.0 nM
Cc1nc(-c2ccccc2)[nH]c1-c1cnc(-c2ccccc2)nc1 CHEMBL3908996 IC50 30.8 nM
O=C(NC1CCN(CC(F)(F)F)CC1)c1ccc(Oc2ccccc2)nc1 CHEMBL3425959 IC50 31.0 nM
CC1C=CC=C1C(=O)N1CCN(C(=O)NC2CCN(c3ccc(C(=O)N4CCOCC4)cc3)CC2)CC1 CHEMBL3698260 IC50 31.0 nM
O=C(N[C@H]1CC[C@H](N[C@H](CO)C(F)(F)F)CC1)c1cnc2cc(C3CC3)ncc2c1 CHEMBL5272443 IC50 31.0 nM
c1ccc(-c2ccc(-c3cnc(-c4ccccc4)[nH]3)cn2)cc1 CHEMBL3917928 IC50 31.6 nM
CCC(=O)Nc1cncc(-c2cccc3[nH]ccc23)c1 CHEMBL3425954 IC50 32.0 nM
Cn1cccc1C(=O)N1CCN(C(=O)Nc2ccc(N3CCC(C(=O)N4CCCCC4)CC3)cc2)CC1 CHEMBL3650210 IC50 32.0 nM
O=C1CC[C@@H](C(=O)Nc2cncc(-c3cccc4[nH]ccc34)c2)N1 CHEMBL3425955 IC50 35.0 nM
O=C(N[C@H]1CC[C@H](N2CC(F)C2)CC1)c1cnc2cc(C3CC3)ncc2c1 CHEMBL5290969 IC50 35.0 nM
CC(C)(O)c1nc(-c2cccc(-c3ncc(-c4ccc(-c5ccccc5)nc4)[nH]3)c2)no1 CHEMBL4757694 IC50 35.4 nM
CC(C)(O)[C@H]1C[C@H](NC(=O)c2cnc3nc(C4CC4)ccc3c2)C1 CHEMBL5283878 IC50 36.0 nM
Cn1cccc1C(=O)N1CCN(C(=O)Nc2ccc(N3CCC(CCCn4ccnn4)CC3)cc2)CC1 CHEMBL3650208 IC50 37.0 nM
CC(C)(C)OC(=O)N1CCC(NC(=O)N2CCc3c(cnn3-c3cccc(F)c3)C2)CC1 CHEMBL4853151 IC50 37.0 nM
C[C@H]1CCN1c1cc2ncc(C(=O)N[C@H]3CCNC3=O)cc2cn1 CHEMBL5274007 IC50 37.0 nM
c1ccc(-c2ncc(-c3ccc(-c4ccccn4)nc3)[nH]2)cc1 CHEMBL4790957 IC50 37.2 nM
CC(C)(O)[C@]12C[C@@](NC(=O)c3cnc4cc(C5CC5)ncc4c3)(C1)C2 CHEMBL5282346 IC50 38.0 nM
CCC1C=CC=C1C(=O)N1CCN(C(=O)NC2CCN(c3ccc(C(=O)NCCN4CCOCC4)cc3)CC2)CC1 CHEMBL3698266 IC50 39.0 nM
O=C(NC1CCCC1)N1Cc2cc(-c3c[nH]nc3C3CC3)cnc2C1 CHEMBL3134496 IC50 40.0 nM
CCNC(=O)N1Cc2cc(-c3c[nH]nc3C3CC3)cnc2C1 CHEMBL3132878 IC50 40.0 nM
Cn1cccc1C(=O)N1CCN(C(=O)Nc2ccc(N3CCC(CCn4cccn4)CC3)cc2)CC1 CHEMBL3650206 IC50 40.0 nM
CC1C=CC=C1C(=O)N1CCN(C(=O)NC2CCN(c3ccc(C(=O)N4CCCCC4)cc3)CC2)CC1 CHEMBL3698261 IC50 41.0 nM
Fc1cccc(-c2ncc(-c3cnc(-c4cccnc4)[nH]3)cn2)c1 CHEMBL3949871 IC50 41.0 nM
O=C(Cn1cnnn1)Nc1cncc(-c2cccc3[nH]ccc23)c1 CHEMBL3425956 IC50 43.0 nM
Cn1cccc1C(=O)N1CCN(C(=O)Nc2ccc(N3CCC(CCN4CCOCC4)CC3)cc2)CC1 CHEMBL3650203 IC50 43.0 nM
O=C(N[C@H]1CCNC1=O)c1cnc2nc(C3CC3)ccc2c1 CHEMBL5282999 IC50 44.0 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)N2CCc3c(cnn3-c3cccc(F)c3)C2)CC1 CHEMBL4852189 IC50 45.0 nM
CC(C)(O)[C@@H]1CC[C@@H](NC(=O)c2ccc3nc(-c4cccc(F)c4)cn3c2)CO1 CHEMBL4872589 IC50 45.0 nM
COc1cc2ncc(C(=O)N[C@H]3CC[C@H](C(C)(C)O)CC3)cc2cn1 CHEMBL5276706 IC50 45.0 nM
Cn1cccc1C(=O)N1CCN(C(=O)Nc2ccc(N3CCC(CCCn4cncn4)CC3)cc2)CC1 CHEMBL3650207 IC50 46.0 nM
CC(C)(C)OC(=O)N1CCC(OC(=O)N2CCc3c(cnn3-c3cccc(F)c3)C2)CC1 CHEMBL4849594 IC50 46.0 nM
Fc1cccc(-c2ncc(-c3cnc(-c4ccccc4)[nH]3)cn2)c1 CHEMBL3916555 IC50 47.0 nM
O=C(NC1CCN(CC(F)(F)F)CC1)c1ccc(N2CCCCC2)nc1 CHEMBL3425960 IC50 48.0 nM
COc1ccc2cc(C(=O)Nc3nccs3)cnc2c1 CHEMBL4454083 IC50 49.0 nM
CC1C=CC=C1C(=O)N1CCN(C(=O)NC2CCN(c3ccc(C(=O)N4CCCC4)cc3)CC2)CC1 CHEMBL3698262 IC50 52.0 nM
O=C(N[C@H]1CCNC1=O)c1cnc2cc(OC(F)F)ccc2c1 CHEMBL4441669 IC50 52.0 nM
c1ccc(-c2ncc(-c3cnc(-c4ccccn4)[nH]3)cn2)cc1 CHEMBL3939974 IC50 53.0 nM
Cn1cccc1C(=O)N1CCN(C(=O)Nc2ccc(N3CCC(CN4CCOCC4)CC3)cc2)CC1 CHEMBL3650201 IC50 54.0 nM
CC(C)(O)c1nc(-c2cccc(CNC(=O)c3ccc(-c4ccccn4)nc3)c2)no1 CHEMBL4782958 IC50 55.5 nM
COc1ccc2cc(C(=O)NC3CCN(c4nnnn4C)CC3)cnc2c1 CHEMBL4483661 IC50 56.0 nM
C[C@]1(O)C[C@@H](NC(=O)c2cnc3cc(N4CCC4)ncc3c2)C1 CHEMBL5284347 IC50 56.0 nM
CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc3cc(OC)ccc3c2)CC1 CHEMBL4435792 IC50 57.0 nM
COc1ccc2cc(C(=O)Nc3cc[nH]n3)cnc2c1 CHEMBL4564218 IC50 57.0 nM
Cn1cccc1C(=O)N1CCN(C(=O)Nc2ccc(N3CCC(O)CC3)cc2)CC1 CHEMBL3650198 IC50 58.0 nM
Cn1cccc1C(=O)N1CCN(C(=O)Nc2ccc(N3CCC(C(=O)NCCN4CCOCC4)CC3)cc2)CC1 CHEMBL3650212 IC50 59.0 nM
c1ccc(Cc2ncc(-c3cnc(-c4ccccc4)nc3)[nH]2)cc1 CHEMBL3907283 IC50 59.0 nM
CN1CCN(C(=O)C2CCN(c3ccc(NC(=O)N4CCN(C(=O)c5cccn5C)CC4)cc3)CC2)CC1 CHEMBL3650211 IC50 60.0 nM
Cn1cccc1C(=O)N1CCN(C(=O)Nc2ccc(N3CCC(C(=O)NCc4cccnc4)CC3)cc2)CC1 CHEMBL3650213 IC50 60.0 nM
Cc1nc(C)n(CCCc2ccc(N3CCC(NC(=O)N4CCN(C(=O)C5=CC=CC5C)CC4)CC3)cc2)n1 CHEMBL3698264 IC50 61.0 nM
Cn1cccc1C(=O)N1CCN(C(=N)Nc2ccc(N3CCC(CCn4cncn4)CC3)cc2)CC1 CHEMBL3650204 IC50 62.0 nM
Cn1c(-c2cnc(-c3ccccc3)nc2)cnc1-c1ccccc1 CHEMBL3893437 IC50 63.1 nM
CC(C)(O)[C@H]1C[C@H](NC(=O)c2cnc3cc(C4CC4)ncc3c2)C1 CHEMBL5289296 IC50 65.0 nM
CC1C=CC=C1C(=O)N1CCN(C(=O)NC2CCN(c3ccc(C(=O)O)cc3)CC2)CC1 CHEMBL3698258 IC50 67.0 nM
Cn1cccc1C(=O)N1CCN(C(=O)Nc2ccc(N3CCC(CCn4cncn4)C3)cc2)CC1 CHEMBL3650202 IC50 67.0 nM
O=C(NC1CCN(CC(F)(F)F)CC1)c1ccc2nc(-c3ccccc3)cn2c1 CHEMBL4868541 IC50 67.0 nM
CCC1C=CC=C1C(=O)N1CCN(C(=O)NC2CCN(c3ccc(CCn4ccnn4)cc3)CC2)CC1 CHEMBL3698267 IC50 68.4 nM
O=C(NC1CCN(CC(F)(F)F)CC1)c1ccc(-c2cc[nH]c(=O)c2)nc1 CHEMBL3425966 IC50 70.0 nM
O=C(NC1CCN(CC(F)(F)F)CC1)c1ccc(-c2cccc(=O)[nH]2)nc1 CHEMBL3425968 IC50 71.0 nM
Cn1cccc1C(=O)N1CCN(C(=O)Nc2ccc(N3CCC(CCn4ccnn4)CC3)cc2)CC1 CHEMBL3639490 IC50 71.0 nM
COc1ccc2cc(C(=O)NCc3ccccc3)cnc2c1 CHEMBL4544169 IC50 71.0 nM
O=C(N[C@H]1CCNC1=O)c1cnc2nc(N3CCC3)ccc2c1 CHEMBL5272062 IC50 71.0 nM
COc1ccc2cc(C(=O)Nc3cc(C)[nH]n3)cnc2c1 CHEMBL4476572 IC50 73.0 nM
Cc1ccc(NC(=O)c2cc(-c3ccccc3)ns2)cc1NC(=O)c1cccc(CN2CCN(C)CC2)c1 CHEMBL258506 IC50 75.0 nM
c1ccc(-c2ncc(-c3cnc(-c4ccncc4)[nH]3)cn2)cc1 CHEMBL3891749 IC50 75.0 nM
Cn1cccc1C(=O)N1CCN(C(=O)Nc2ccc(N3CCC(C(=O)N4CCOCC4)CC3)cc2)CC1 CHEMBL3650200 IC50 76.0 nM
COc1ccc2cc(C(=O)Nc3ccn(C)n3)cnc2c1 CHEMBL4573375 IC50 78.0 nM
Cn1cccc1C(=O)N1CCN(C(=O)Nc2ccc(N3CCC(C(=O)N4CCN(c5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)CC3)cc2)CC1 CHEMBL5193611 IC50 78.1 nM
O=C(NCc1ccccc1)c1ccc(-c2ccccn2)nc1 CHEMBL4783155 IC50 80.7 nM
c1ccc(-c2ncc(-c3nnc(-c4ccccc4)[nH]3)cn2)cc1 CHEMBL3951958 IC50 84.0 nM
Cc1nc(C)n(CCC2CCN(c3ccc(NC(=O)N4CCN(C(=O)c5cccn5C)CC4)cc3)CC2)n1 CHEMBL3650205 IC50 85.0 nM
Cn1cccc1C(=O)N1CCN(C(=O)Nc2ccc(N3CCC(C(=O)O)CC3)cc2)CC1 CHEMBL3650199 IC50 86.0 nM
C[C@H](NC(=O)c1ccc(-c2cccs2)nc1)c1ccc2ccccc2c1 CHEMBL3969098 IC50 86.0 nM
O=C(N1CCCC(c2nc(-c3cnc(-c4ccccc4)nc3)c[nH]2)C1)C(F)(F)F CHEMBL3934855 IC50 90.0 nM
CCn1cccc1C(=O)N1CCN(C(=O)Nc2ccc(N3CCC(C(=O)N4CCOCC4)CC3)cc2)CC1 CHEMBL3650209 IC50 91.0 nM
COc1ccc2cc(C(=O)N[C@H]3CCNC3=O)cnc2c1 CHEMBL4461589 IC50 98.0 nM
COc1ccc2cc(C(=O)NC3CCCCC3)cnc2c1 CHEMBL4438813 IC50 100.0 nM
O=C(Nc1nc2ccc(Br)cc2s1)N1CCN(C(=O)c2cccc(F)c2)CC1 CHEMBL3650193 IC50 106.0 nM
COc1ccc2cc(C(=O)NC3CCN(S(C)(=O)=O)CC3)cnc2c1 CHEMBL4591235 IC50 110.0 nM
COc1ccc2cc(C(=O)N[C@H]3CC[C@H](O)CC3)cnc2c1 CHEMBL4446601 IC50 110.0 nM
O=C(N[C@H]1CCNC1=O)c1cnc2cc(C3CC3)ncc2c1 CHEMBL5270752 IC50 110.0 nM
O=C1CCC(N2C(=O)c3cccc(N4CCN(C(=O)C5CCN(c6ccc(NC(=O)c7cnc(Oc8ccccc8)nc7)cc6)CC5)CC4)c3C2=O)C(=O)N1 CHEMBL5076100 IC50 116.5 nM
Cn1nnnc1N1CCC(NC(=O)c2cnc3cc(OC(F)(F)F)ccc3c2)CC1 CHEMBL4476594 IC50 120.0 nM
COc1ccc2cc(C(=O)N[C@H]3CC[C@](C)(O)CC3)cnc2c1 CHEMBL4584855 IC50 120.0 nM
O=C(NCc1ccccc1)c1ccc(-c2ccccc2)nc1 CHEMBL4781374 IC50 122.0 nM
Cn1cccc1C(=O)N1CCN(C(=O)Nc2ccc(N3CCC(C(=O)N4CCN(c5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)CC3)cc2)CC1 CHEMBL5207946 IC50 123.9 nM
O=C(CCN1CCCCC1)Nc1cncc(-c2cccc3[nH]ccc23)c1 CHEMBL3425957 IC50 130.0 nM
CCOC(=O)c1cc(-c2cnc(Oc3ccccc3)nc2)[nH]n1 CHEMBL3910963 IC50 130.0 nM
Cc1cc(-c2csc(Nc3ccc(C(=O)O)c(O)c3)n2)ccc1F CHEMBL258467 IC50 138.0 nM
CN1C(=O)CCC(N2C(=O)c3cccc(N4CCN(C(=O)C5CCN(c6ccc(NC(=O)c7cnc(Oc8ccccc8)nc7)cc6)CC5)CC4)c3C2=O)C1=O CHEMBL5075403 IC50 140.0 nM
COc1ncc2cc(C(=O)N[C@H]3CC[C@H](C(C)(C)O)CC3)cnc2n1 CHEMBL5273807 IC50 140.0 nM
C[C@]1(O)C[C@@H](NC(=O)c2cnc3nc(N4CCC4)ccc3c2)C1 CHEMBL5266934 IC50 140.0 nM
CC(C)(C)OC(=O)N1CCC(c2ncc(-c3cnc(-c4ccccc4)nc3)[nH]2)CC1 CHEMBL3925383 IC50 150.0 nM
CC(C)(C)OC(=O)N1CCC(c2ncc(-c3cnc(-c4ccccc4)nc3)[nH]2)C1 CHEMBL3910500 IC50 150.0 nM
c1ccc(-c2ncc(-c3csc(-c4cccnc4)n3)cn2)cc1 CHEMBL3952523 IC50 150.0 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc3nc(NCC(F)F)ccc3c2)CC1 CHEMBL5290285 IC50 150.0 nM
COc1ccc2cc(C(=O)NCc3ccnn3C)cnc2c1 CHEMBL4539130 IC50 160.0 nM
CS(=O)(=O)N1CCC(NC(=O)N2CCc3c(cnn3-c3cccc(F)c3)C2)CC1 CHEMBL4864256 IC50 160.0 nM
C[C@@H]1CCN1c1cc2ncc(C(=O)N[C@H]3CC[C@H](C(C)(C)O)CC3)cc2cn1 CHEMBL5274174 IC50 160.0 nM
C[C@]1(O)C[C@@H](NC(=O)c2cnc3nc(C4CC4)ccc3c2)C1 CHEMBL5283830 IC50 160.0 nM
COCCCNC(=O)c1nc(-c2cccc3[nH]ccc23)no1 CHEMBL3425952 IC50 170.0 nM
COc1ccc2cc(C(=O)NC3CCOCC3)cnc2c1 CHEMBL4567043 IC50 170.0 nM
CN(C)CCCC(=O)Nc1cncc(-c2cccc3[nH]ccc23)c1 CHEMBL3425950 IC50 180.0 nM
Cc1csc(-c2ccc(C(=O)N[C@@H](C)c3ccc4ccccc4c3)cn2)c1 CHEMBL3931600 IC50 180.0 nM
COc1cnc2cc(C(=O)N[C@H]3CC[C@H](C(C)(C)O)CC3)cnc2c1 CHEMBL5290010 IC50 180.0 nM
O=C1CCC(N2C(=O)c3ccc(N4CCN(C(=O)C5CCN(c6ccc(NC(=O)c7cnc(Oc8ccccc8)nc7)cc6)CC5)CC4)cc3C2=O)C(=O)N1 CHEMBL5200341 IC50 196.3 nM
Nc1c(S(=O)(=O)O)cc(Nc2ccc(Nc3nc(Cl)nc(Nc4ccccc4S(=O)(=O)O)n3)c(S(=O)(=O)O)c2)c2c1C(=O)c1ccccc1C2=O CHEMBL572528 IC50 200.0 nM
O=C(NC1CCN(CC(F)(F)F)CC1)c1ccc(N2CCCC2)nc1 CHEMBL3425961 Kd 200.0 nM
CC(C)(C)OC(=O)N1CCCC(c2ncc(-c3cnc(-c4ccccc4)nc3)[nH]2)C1 CHEMBL3969450 IC50 200.0 nM
COc1ccc2cc(C(=O)NC3CCCC3)cnc2c1 CHEMBL4571908 IC50 200.0 nM
COc1ccc2cc(C(=O)Nc3cn[nH]c3)cnc2c1 CHEMBL4580109 IC50 200.0 nM
O=C(NCCN1CCOCC1)c1ccc(N2CCC(NC(=O)N3CCN(C(=O)c4cccs4)CC3)CC2)cc1 CHEMBL3698271 IC50 201.0 nM
O=C(Nc1nc2ccc(Cl)cc2s1)N1CCN(C(=O)c2cccc(F)c2)CC1 CHEMBL3650197 IC50 204.0 nM
CN(C)CCC(=O)Nc1cncc(-c2cccc3[nH]ccc23)c1 CHEMBL3425951 Kd 210.0 nM
COc1ccc2cc(C(=O)NC3CCCNC3=O)cnc2c1 CHEMBL4461716 IC50 220.0 nM
COc1ccc2cc(C(=O)Nc3ccnn3C)cnc2c1 CHEMBL4555427 IC50 220.0 nM
Cc1cc2nc(NC(=O)N3CCN(C(=O)c4cccc(F)c4)CC3)sc2cc1C CHEMBL3650194 IC50 222.0 nM
O=C(N[C@H]1CCNC1=O)c1cnc2cc(OC(F)(F)F)ccc2c1 CHEMBL4469614 IC50 230.0 nM
CS(=O)(=O)N1CC(NC(=O)N2CCc3c(cnn3-c3cccc(F)c3)C2)C1 CHEMBL4859293 IC50 230.0 nM
O=C(NCCN1CCOCC1)c1ccc(N2CCC(NC(=O)N3CCN(C(=O)c4ccccc4)CC3)CC2)cc1 CHEMBL3698278 IC50 249.0 nM
COc1ccc2cc(C(=O)NC3CCN(C(C)=O)CC3)cnc2c1 CHEMBL4570414 IC50 250.0 nM
COc1ccc2cc(C(=O)NCc3cc[nH]c(=O)c3)cnc2c1 CHEMBL4520564 IC50 250.0 nM
c1ccc(-c2ncc(-c3cnc(-c4cccnc4)s3)cn2)cc1 CHEMBL4798065 IC50 257.0 nM
Cc1ccc2nc(NC(=O)N3CCN(C(=O)c4cccc(F)c4)CC3)sc2c1 CHEMBL3650195 IC50 260.0 nM
O=C1CCC(N2C(=O)c3cccc(NCCOCCOCCOCCOCCOCCC(=O)N4CCN(C(=O)C5CCN(c6ccc(NC(=O)c7cnc(Oc8ccccc8)nc7)cc6)CC5)CC4)c3C2=O)C(=O)N1 CHEMBL4762935 IC50 266.0 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2ccc3nc(-c4ccc(F)cc4)cn3c2)CC1 CHEMBL4849005 IC50 270.0 nM
O=C(NCCN1CCOCC1)c1ccc(-c2ccccn2)cc1 CHEMBL2035652 IC50 274.0 nM
O=C(Nc1ccc(N2CCN(C(=O)N3CCOCC3)CC2)cc1)c1cnc(Oc2ccccc2)nc1 CHEMBL2035649 IC50 280.0 nM
COc1ccc2cc(C(=O)N[C@H]3C[C@@](C)(O)C3)cnc2c1 CHEMBL4446712 IC50 280.0 nM
C[C@]1(O)C[C@@H](NC(=O)c2cnc3cc(C4CC4)ncc3c2)C1 CHEMBL5284243 IC50 290.0 nM
c1ccc(-c2ncc(-c3cnc(CCc4cccnc4)[nH]3)cn2)cc1 CHEMBL3953132 IC50 300.0 nM
CNC(=O)N1CCCC(c2nc(-c3cnc(-c4ccccc4)nc3)cn2C(=O)NC)C1 CHEMBL3897764 IC50 300.0 nM
CN1C(=O)CCC(N2C(=O)c3cccc(NCCOCCOCCOCCOCCOCCC(=O)N4CCN(C(=O)C5CCN(c6ccc(NC(=O)c7cnc(Oc8ccccc8)nc7)cc6)CC5)CC4)c3C2=O)C1=O CHEMBL4758395 IC50 300.0 nM
C[C@]1(O)C[C@H](NC(=O)c2cnc3nc(C4CC4)ccc3c2)C1 CHEMBL5276861 IC50 300.0 nM
C[C@@H]1CCN1c1ccc2cc(C(=O)N[C@H]3CC[C@H](C(C)(C)O)CC3)cnc2n1 CHEMBL5267306 IC50 310.0 nM
COc1ccc2nc(NC(=O)N3CCN(C(=O)c4cccc(F)c4)CC3)sc2c1 CHEMBL3650196 IC50 318.0 nM
O=C(NC1CCN(CC(F)(F)F)CC1)c1ccc(N2CCOCC2)nc1 CHEMBL3425963 IC50 320.0 nM
COc1ccc2cc(C(=O)NCc3ccn[nH]3)cnc2c1 CHEMBL4469436 IC50 320.0 nM
O=C(NCCN1CCOCC1)c1ccc(N2CCC(NC(=O)N3CCN(C(=O)c4ccsc4)CC3)CC2)cc1 CHEMBL3698272 IC50 327.0 nM
O=C(NCCN1CCOCC1)c1ccc(N2CCC(NC(=O)N3CCN(C(=O)c4ccc[nH]4)CC3)CC2)cc1 CHEMBL3698268 IC50 334.0 nM
O=C(Nc1ccc(N2CCC(C(=O)N3CCOCC3)CC2)cc1)N1CCN(C(=O)c2cccs2)CC1 CHEMBL3650217 IC50 340.0 nM
COc1ccc2cc(C(=O)N[C@H]3C[C@@H](O)C3)cnc2c1 CHEMBL4520607 IC50 340.0 nM
COc1ccc2cc(C(=O)NC3C(=O)Nc4ccccc43)cnc2c1 CHEMBL4521862 IC50 350.0 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc3nc(OCC(F)(F)F)ccc3c2)CC1 CHEMBL5280283 IC50 350.0 nM
COc1ccc2cc(C(=O)NCc3ccn(C)n3)cnc2c1 CHEMBL4547202 IC50 360.0 nM
c1ccc(Oc2ncc(-c3cnc(-c4cccnc4)[nH]3)cn2)cc1 CHEMBL3979391 IC50 370.0 nM
Cc1csc(-c2ccc(C(=O)N[C@@H](Cc3ccccc3)C(N)=O)cn2)c1 CHEMBL3934630 IC50 380.0 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)N2CCc3c(cnn3-c3ccccc3F)C2)CC1 CHEMBL4878511 IC50 380.0 nM
COc1ccc2cc(C(=O)Nc3ncc[nH]3)cnc2c1 CHEMBL4547648 IC50 390.0 nM
CN1CCN(C(=O)c2cc(-c3cnc(Oc4ccccc4)nc3)[nH]n2)CC1 CHEMBL3936099 IC50 420.0 nM
COc1ccc2cc(C(=O)NCc3nnn[nH]3)cnc2c1 CHEMBL4550149 IC50 420.0 nM
O=C(Nc1ccc(N2CCC(C(=O)N3CCOCC3)CC2)cc1)N1CCN(C(=O)c2ccccc2)CC1 CHEMBL3650224 IC50 437.0 nM
O=C(NCCN1CCOCC1)c1ccc(N2CCC(NC(=O)N3CCN(C(=O)c4ccco4)CC3)CC2)cc1 CHEMBL3698273 IC50 445.0 nM
O=C(c1cccnc1)N1CCC(c2nc(-c3cnc(-c4ccccc4)nc3)c[nH]2)CC1 CHEMBL3898706 IC50 450.0 nM
COc1ccc2nc(C(=O)N[C@H]3CC[C@H](C(C)(C)O)CC3)cnc2c1 CHEMBL5268207 IC50 490.0 nM
c1nc(NC2CCCC2)c2cc[nH]c2n1 CHEMBL3134492 IC50 500.0 nM
COc1ccc2cc(C(=O)N[C@H]3C[C@H](O)C3)cnc2c1 CHEMBL4525227 IC50 500.0 nM
COc1ccc2cc(C(=O)NCCN3CCNC3=O)cnc2c1 CHEMBL4563481 IC50 520.0 nM
COc1ccc2cc(C(=O)NCc3cn(C)cn3)cnc2c1 CHEMBL4468172 IC50 530.0 nM
O=C1CN(c2ccc(C(=O)NC3CCN(CC(F)(F)F)CC3)cn2)CCN1 CHEMBL3425965 IC50 590.0 nM
COc1ccc2cc(C(=O)N[C@H]3CCOC3)cnc2c1 CHEMBL4552112 IC50 590.0 nM
O=C(NCc1ccccc1)c1ccc(-c2cccs2)nc1 CHEMBL3940173 IC50 597.0 nM
c1ccc(CN2CCCC(c3ncc(-c4cnc(-c5ccccc5)nc4)[nH]3)C2)cc1 CHEMBL3960678 IC50 600.0 nM
COc1ccc2cc(C(=O)N[C@H]3C[C@](C)(O)C3)cnc2c1 CHEMBL4547156 IC50 610.0 nM
COc1ccc2cc(C(=O)N[C@H]3CNC(=O)C3)cnc2c1 CHEMBL4575981 IC50 620.0 nM
COc1ccc2cc(C(=O)N[C@H]3CONC3=O)cnc2c1 CHEMBL4588916 IC50 630.0 nM
COc1ccc2cc(C(=O)N[C@@H]3C(=O)NC[C@H]3O)cnc2c1 CHEMBL4461342 IC50 640.0 nM
O=C(O)c1ccc(CNC(=O)c2ccc(-c3cccs3)nc2)cc1 CHEMBL3934642 IC50 660.0 nM
O=C(NCCN1CCOCC1)c1ccc(-c2c(O)ccc3ccccc23)cc1 CHEMBL2035654 IC50 662.0 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc3nc(NCC(F)(F)F)ccc3c2)CC1 CHEMBL5282301 IC50 690.0 nM
O=C(NC(c1ccccc1)c1ccccc1)c1ccc(-c2cccc(O)c2)s1 CHEMBL1215159 IC50 700.0 nM
O=C(Nc1ccc(N2CCC(C(=O)N3CCOCC3)CC2)cc1)N1CCN(C(=O)c2ccsc2)CC1 CHEMBL3650218 IC50 732.0 nM
NC(=O)c1ccc(-c2cccc(F)c2)nc1 CHEMBL3425970 Kd 800.0 nM
NCc1ccc2ccccc2c1-c1ccc(C(=O)NCCN2CCOCC2)cc1 CHEMBL2035656 IC50 845.0 nM
CC(NC(=O)C(Cc1ccccc1)NC(=O)c1ccc(-c2cccs2)nc1)C(N)=O CHEMBL3903606 IC50 860.0 nM
COc1ccc2cc(C(=O)NC(C)C)cnc2c1 CHEMBL4476387 IC50 870.0 nM
COc1ccc2c(c1)N=CN(C(=O)N[C@H]1CC[C@H](C(C)(C)O)CC1)C2 CHEMBL5273582 IC50 890.0 nM
c1ccc(-c2cc(-c3cc[nH]n3)on2)cc1 CHEMBL265720 IC50 920.0 nM
COc1ccccc1-c1csc(Nc2ccc(C(=O)O)cc2)n1 CHEMBL264951 IC50 994.0 nM
NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)c1ccc(-c2cccc(O)c2)cc1 CHEMBL1215370 IC50 1000.0 nM
c1ccc(-c2ncc(-c3cnc(C4CCNCC4)[nH]3)cn2)cc1 CHEMBL3949654 IC50 1000.0 nM