CN(CC1(C(=O)NC2C3CC4CC2CC(C(N)=O)(C4)C3)CC1)S(=O)(=O)c1ccccc1F CHEMBL3897844 IC50 0.02 nM
CN(CC1(C(=O)NC23CC4CC(C2)CC(C(N)=O)(C4)C3)CC1)S(=O)(=O)c1ccccc1F CHEMBL5289716 IC50 0.02 nM
O=C(NC1C2CC3CC(C2)CC1C3)[C@H]1CCCN1CC1CCCC1 CHEMBL1096870 IC50 0.03 nM
CC(C)CN1CCC[C@@H]1C(=O)NC1C2CC3CC(C2)CC1C3 CHEMBL1098130 IC50 0.03 nM
O=C(NC1C2CC3CC(C2)CC1C3)[C@H]1CCCN1CC1CCC1 CHEMBL1098131 IC50 0.03 nM
N#Cc1ccc(CN2CCC[C@@H]2C(=O)NC2C3CC4CC(C3)CC2C4)cc1 CHEMBL1098145 IC50 0.03 nM
O=C(NC1C2CC3CC(C2)CC1C3)[C@H]1CCCN1CC1(O)CCCCC1 CHEMBL1096451 IC50 0.03 nM
N#Cc1ccc(-c2ccc(S(=O)(=O)Nc3ccc4ccccc4n3)cc2)cc1 CHEMBL2377209 EC50 0.03 nM
Cc1c(Cl)cccc1S(=O)(=O)N1CCC[C@]1(C)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 CHEMBL2152223 IC50 0.1 nM
CC(C)(NS(=O)(=O)c1ccc(F)cc1Cl)C(=O)NC1C2CC3CC1CC(C(N)=O)(C3)C2 CHEMBL3609877 IC50 0.1 nM
CC1CCN(c2c(Cl)cc(Cl)cc2Cl)S(=O)(=O)N1CC(=O)NC1C2CC3CC1CC(C(N)=O)(C3)C2 CHEMBL3663670 IC50 0.1 nM
CN1C[C@@H]2C[C@H]1CN2S(=O)(=O)c1ccc(C(C)(C)C)cc1 CHEMBL1081251 IC50 0.11 nM
CN(C1(C(=O)NC2C3CC4CC2CC(C(N)=O)(C4)C3)CC1)S(=O)(=O)c1cccc(Cl)c1 CHEMBL3961200 IC50 0.12 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@H](CCC#N)CC2)cc1)C(F)(F)F CHEMBL512355 IC50 0.2 nM
CC(C)(NS(=O)(=O)c1cc(Cl)cc(Cl)c1)C(=O)NC1C2CC3CC1CC(C(N)=O)(C3)C2 CHEMBL3608403 IC50 0.2 nM
NC(=O)C12CC3CC(C1)C(NC(=O)CN1CCCN(c4c(Cl)cc(Cl)cc4Cl)S1(=O)=O)C(C3)C2 CHEMBL3663666 IC50 0.2 nM
Cn1c(-c2ccccc2Cl)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL497748 IC50 0.28 nM
CC(C)(NS(=O)(=O)c1cc(Cl)ccc1Cl)C(=O)NC1C2CC3CC1CC(C(N)=O)(C3)C2 CHEMBL3608400 IC50 0.3 nM
CC1(CO)Cc2nnc(C3(c4ccc(-c5cccnc5)c(F)c4)CC3)n2CCS1 CHEMBL3681931 IC50 0.3 nM
NC(=O)C12CC3CC(C1)C(NC(=O)C1(CNS(=O)(=O)c4cccc(Cl)c4F)CC1)C(C3)C2 CHEMBL3895758 IC50 0.3 nM
O=C(CC1(c2ccc(F)cc2)C2CC3CC(C2)CC1C3)N1CCCC1 CHEMBL4073961 IC50 0.3 nM
C[C@@H](c1ccc(-c2cc[nH]c(=O)c2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL3664636 IC50 0.31 nM
O=C(NC1C2CC3CC(C2)CC1C3)[C@H]1CCCN1CC1CCCCC1 CHEMBL1097177 IC50 0.32 nM
O=C(NC1C2CC3CC(C2)CC1C3)[C@H]1CCCN1CC(F)(F)F CHEMBL1097178 IC50 0.32 nM
O=C(NC1C2CC3CC(C2)CC1C3)[C@H]1CCCN1CCC(F)(F)F CHEMBL1097827 IC50 0.32 nM
O=C(NC1C2CC3CC(C2)CC1C3)[C@H]1CCCN1Cc1ccc(Cl)cc1 CHEMBL1097828 IC50 0.32 nM
N#Cc1cccc(CN2CCC[C@@H]2C(=O)NC2C3CC4CC(C3)CC2C4)c1 CHEMBL1098159 IC50 0.32 nM
CN1C[C@@H]2C[C@H]1CN2S(=O)(=O)c1ccc(CC(C)(C)C)cc1 CHEMBL1080752 IC50 0.33 nM
Cn1c(-c2ccc(O)cc2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL494180 IC50 0.34 nM
O=C(NC1C2CC3CC(C2)CC1C3)[C@H]1CCCN1CC1(O)CCCC1 CHEMBL1095787 IC50 0.34 nM
CC(C)(NS(=O)(=O)c1c(F)cccc1F)C(=O)NC1C2CC3CC1CC(C(N)=O)(C3)C2 CHEMBL3963976 IC50 0.36 nM
C[C@@H]1CN(CC2(c3ccncc3)CC2)CCN1S(=O)(=O)c1ccc(C(C)(O)C(F)(F)F)cc1 CHEMBL522964 IC50 0.4 nM
N#Cc1cccnc1N[C@@H]1CCN(C(=O)O[C@H]2C3CC4CC2C[C@](C(N)=O)(C4)C3)C1 CHEMBL1269895 IC50 0.4 nM
C[C@@H](c1ccc(-c2ccc(F)cc2)cc1)N1CC[C@](CCCO)(c2ccccc2)OC1=O CHEMBL1829761 IC50 0.4 nM
Cc1c(Cl)cccc1S(=O)(=O)N1CCC[C@H](C(=O)N[C@H]2C[C@H]3CC[C@]2(C)C3(C)C)C1 CHEMBL2152217 IC50 0.4 nM
N#CC1CC(Oc2nc([C@H]3CCCO3)c(C(=O)NC3C4CC5CC3CC(O)(C5)C4)s2)C1 CHEMBL3127857 IC50 0.4 nM
COc1nc([C@H]2CCCO2)c(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)s1 CHEMBL3127854 IC50 0.4 nM
Cc1c(Cl)cccc1S(=O)(=O)N1CCC[C@H](C(=O)N[C@H]2C[C@@H]3CC[C@@]2(C)C3(C)C)C1 CHEMBL3287025 IC50 0.4 nM
CC(C)(NS(=O)(=O)c1c(F)cccc1F)C(=O)NC1C2CC3CC1CC(C(N)=O)(C3)C2 CHEMBL3608401 IC50 0.4 nM
NC(=O)C12CC3CC(C1)C(NC(=O)CN1CCCCN(c4c(Cl)cc(Cl)cc4Cl)S1(=O)=O)C(C3)C2 CHEMBL3639625 IC50 0.4 nM
Cn1ccc2cccc(S(=O)(=O)NC3(C(=O)NC4C5CC6CC4CC(C(N)=O)(C6)C5)CC3)c21 CHEMBL3899122 IC50 0.4 nM
C[C@@H](c1ccc(-c2ccncc2)cc1)N1CC[C@](CCCO)(c2ccccc2)OC1=O CHEMBL4101787 IC50 0.4 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1sc(OCC2CC2)nc1C1CC1 CHEMBL3127868 IC50 0.43 nM
COC[C@H](C)Oc1nc([C@H]2CCCO2)c(C(=O)NC2C3CC4CC2CC(O)(C4)C3)s1 CHEMBL3127856 IC50 0.45 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](OC(=O)N1CC[C@@H](n4c(=O)[nH]c5cccc(Cl)c54)C1)C(C3)C2 CHEMBL4109576 IC50 0.46 nM
Cn1ccc(-c2csc([C@H]3CCCN3C(=O)OC3C4CC5CC(C4)CC3C5)n2)cc1=O CHEMBL4108485 IC50 0.47 nM
COCCOc1nc([C@H]2CCCO2)c(C(=O)NC2C3CC4CC2CC(O)(C4)C3)s1 CHEMBL3127855 IC50 0.49 nM
CC(C)n1nc(-c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)ccc1=O CHEMBL3645514 IC50 0.49 nM
C[C@@H]1CN(CC2(c3cccnc3)CCC2)CCN1S(=O)(=O)c1ccc(C(C)(O)C(F)(F)F)cc1 CHEMBL490966 IC50 0.5 nM
C[C@@H]1CN(CC2(c3cccnc3)CC2)CCN1S(=O)(=O)c1ccc(C(C)(O)C(F)(F)F)cc1 CHEMBL522463 IC50 0.5 nM
O=C(N1CCC2(CCCCC2)C1)C1(c2ccccc2)CC1 CHEMBL557417 IC50 0.5 nM
NC(=O)CC1CC2(CCN(C(=O)NC3C4CC5CC(C4)CC3C5)CC2)c2c(Br)cccc21 CHEMBL601211 IC50 0.5 nM
NC(=O)[C@]12CC3CC(C1)[C@H](OC(=O)N1CC[C@H](Nc4ncccc4C(F)(F)F)C1)C(C3)C2 CHEMBL1271428 IC50 0.5 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@](COC(N)=O)(c3ccc(F)cc3)CC2)cc1)C(F)(F)F CHEMBL1642601 IC50 0.5 nM
C[C@@H](c1ccc(-c2ccc(F)cc2)cc1)N1CC[C@](CCO)(c2ccc(F)cc2)OC1=O CHEMBL1829768 IC50 0.5 nM
C[C@@H](c1ccc(-c2ccc(F)cc2)cc1)N1CC[C@](CCO)(c2ccccc2)OC1=O CHEMBL1829760 IC50 0.5 nM
FC(F)(F)Oc1ccccc1Oc1cccn2c(C3(c4ccc(Cl)cc4)CC3)nnc12 CHEMBL3318967 IC50 0.5 nM
C[C@@H](c1ccc(-c2cncc(F)c2)cc1)N1CC[C@](CCCO)(c2ccccc2)OC1=O CHEMBL4075869 IC50 0.5 nM
CC(C)(CCO)c1cccn2c(C3(c4ccc(Cl)cc4)CC3)nnc12 CHEMBL4453347 IC50 0.5 nM
O=C(OC1C2CC3CC(C2)CC1C3)N1CCC(c2ncc(Cl)cn2)C1 CHEMBL3981658 IC50 0.52 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](OC(=O)N1CC[C@@H](Oc4ncc(F)cc4F)C1)C(C3)C2 CHEMBL4112242 IC50 0.54 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](OC(=O)N1CC[C@H](Oc4ccc(C(F)(F)F)cn4)C1)C(C3)C2 CHEMBL4108552 IC50 0.54 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](OC(=O)N1CC[C@@H](Nc4ncccc4C(F)(F)F)C1)C(C3)C2 CHEMBL1271218 IC50 0.55 nM
C[C@@H](c1ccc(-c2ccc(F)cc2)cc1)N1CC[C@](CCC(N)=O)(c2ccccc2)OC1=O CHEMBL3645524 IC50 0.55 nM
C[C@@H](c1ccc(-c2ccc(=O)[nH]c2)cc1)N1CC[C@](CC(C)(C)C#N)(c2ccc(F)cc2)OC1=O CHEMBL3664644 IC50 0.58 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@H](CC3(C#N)CC3)CC2)cc1)C(F)(F)F CHEMBL491326 IC50 0.6 nM
C[C@@H]1CN(CC2(c3cccnc3)CCCC2)CCN1S(=O)(=O)c1ccc(C(C)(O)C(F)(F)F)cc1 CHEMBL491146 IC50 0.6 nM
C[C@@H]1CN(CC2(c3ccncc3)CCC2)CCN1S(=O)(=O)c1ccc(C(C)(O)C(F)(F)F)cc1 CHEMBL491141 IC50 0.6 nM
C[C@](O)(c1ccc(S(=O)(=O)c2ccc(-c3ccc(C#N)cc3)cc2C2CC2)cc1)C(F)(F)F CHEMBL1289521 IC50 0.6 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@](COC(N)=O)(c3ccccc3F)CC2)cc1)C(F)(F)F CHEMBL1642600 IC50 0.6 nM
C[C@@H](c1ccc(-c2ccc(F)cc2)cc1)N1CC[C@](CCCO)(c2ccc(F)cc2)OC1=O CHEMBL1829767 IC50 0.6 nM
CC[C@@H](c1ccc(-c2ccc(F)cc2)cc1)N1CC[C@](CCCO)(c2ccccc2)OC1=O CHEMBL1829762 IC50 0.6 nM
C[C@@H](c1ccc(-c2ccc(F)cc2F)cc1)N1CC[C@](CCCO)(c2ccccc2)OC1=O CHEMBL1829759 IC50 0.6 nM
CC(C)(NS(=O)(=O)c1ccccc1F)C(=O)NC1C2CC3CC1CC(C(N)=O)(C3)C2 CHEMBL3609861 IC50 0.6 nM
CC(C)(NS(=O)(=O)c1ccccc1F)C(=O)NC1C2CC3CC1CC(C(N)=O)(C3)C2 CHEMBL3983188 IC50 0.6 nM
O=C(CC1(c2ccc(F)cc2)C2CC3CC(C2)CC1C3)N1CC(CO)C1 CHEMBL4071232 IC50 0.6 nM
COc1ccc(-c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)cn1 CHEMBL4069717 IC50 0.6 nM
C[C@@H](c1ccc(-c2ccccn2)cc1)N1CC[C@](CCCO)(c2ccccc2)OC1=O CHEMBL4060843 IC50 0.6 nM
C[C@@H](c1ccc(-c2ccc(F)cn2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL4096179 IC50 0.6 nM
O=C1O[C@]2(CCN(C(=O)C3(c4ccc(Cl)cc4)CC3)C2)c2ccccc21 CHEMBL5205840 IC50 0.6 nM
CC(C)c1cccn2c(C3(c4ccc(Cl)cc4)CC3)nnc12 CHEMBL3318979 IC50 0.61 nM
C[C@@H](c1ccc(-c2ccn(C)c(=O)c2)cc1)N1CC[C@](CC(C)(C)C#N)(c2ccccc2)OC1=O CHEMBL3639635 IC50 0.61 nM
C#CC(C)(C)C[C@]1(c2ccccc2)CCN([C@@H](C)c2ccc(-c3ccc(=O)[nH]c3)cc2)C(=O)O1 CHEMBL3664719 IC50 0.65 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](OC(=O)N1CC[C@@H](Nc4cccc(C(F)(F)F)n4)C1)C(C3)C2 CHEMBL1271427 IC50 0.67 nM
Cn1c(=O)n([C@H]2CCN(C(=O)O[C@H]3C4CC5CC3C[C@](C(N)=O)(C5)C4)C2)c2c(Cl)cccc21 CHEMBL4110044 IC50 0.67 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](OC(=O)N1CC[C@H](Oc4ncc(F)cc4F)C1)C(C3)C2 CHEMBL4113055 IC50 0.68 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](OC(=O)N1CC[C@H](n4c(=O)[nH]c5cccc(Cl)c54)C1)C(C3)C2 CHEMBL4109705 IC50 0.68 nM
C[C@@H]1CN(CC2(C(N)=O)CC2)CCN1S(=O)(=O)c1ccc([C@](C)(O)C(F)(F)F)cc1 CHEMBL460962 IC50 0.7 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@H](c3ccc(C#N)cc3)CC2)cc1)C(F)(F)F CHEMBL511828 IC50 0.7 nM
O=C(NC1C2CC3CC(C2)CC1C3)N1CCCC2(Cc3ccccc3C2)C1 CHEMBL596620 IC50 0.7 nM
C[C@@H](c1ccc(-c2ccc(F)cc2F)cc1)N1CC[C@](CCO)(c2ccccc2)OC1=O CHEMBL1829758 IC50 0.7 nM
Fc1ccccc1Oc1cccn2c(C3(c4ccc(Cl)cc4)CC3)nnc12 CHEMBL3318965 IC50 0.7 nM
O=C(OC1C2CC3CC(C2)CC1C3)N1CCC(c2nc(-c3ccncc3)cs2)C1 CHEMBL3982412 IC50 0.7 nM
O=C(CC1(c2ccc(-c3ccc(F)cc3)cc2)C2CC3CC1CC(C2)C3O)N1CC(O)C1 CHEMBL4102283 IC50 0.7 nM
C[C@@H](c1ccc(Br)cc1)N1CC[C@](CCCNS(C)(=O)=O)(c2ccc(F)cc2)OC1=O CHEMBL4090672 IC50 0.7 nM
C[C@@H](c1ccc(OC(F)F)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL4103620 IC50 0.7 nM
C[C@@H](c1ccc(-c2ccc(=O)n(C)c2)cc1)N1CC[C@](CC(C)(C)C#N)(c2ccc(F)cc2)OC1=O CHEMBL3664675 IC50 0.72 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](OC(=O)N1CC[C@H](Nc4ccc(C(F)(F)F)cn4)C1)C(C3)C2 CHEMBL1269894 IC50 0.74 nM
C[C@@H](c1ccc(-c2ccc(F)cc2F)cc1)N1CC[C@](CCO)(c2ccc(F)cc2)OC1=O CHEMBL1829763 IC50 0.75 nM
CC[C@@H](c1ccc(-c2ccc(=O)n(C(C)C)c2)cc1)N1CC[C@](CC)(c2ccccc2)OC1=O CHEMBL3664666 IC50 0.75 nM
C[C@@H](c1ccc(Br)cc1)N1CC[C@](CC(C)(C)O)(c2ccc(F)cc2)OC1=O CHEMBL3645526 IC50 0.76 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](OC(=O)N1CC[C@H](n4c(=O)[nH]c5ccccc54)C1)C(C3)C2 CHEMBL4114288 IC50 0.76 nM
O=C1O[C@@](CCO)(c2ccccc2)CCN1c1cccc(-c2ccc(F)cc2F)c1 CHEMBL3645520 IC50 0.77 nM
C[C@@H](c1ccc(Br)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL3645528 IC50 0.79 nM
C[C@@H]1CN(CC2(c3ccncc3)CCCC2)CCN1S(=O)(=O)c1ccc(C(C)(O)C(F)(F)F)cc1 CHEMBL490967 IC50 0.8 nM
C[C@](O)(c1ccc(C(=O)N(C2CCCCC2)C2CC2)cc1)C(F)(F)F CHEMBL469698 IC50 0.8 nM
O=C(NC1C2CC3CC(C2)CC1C3)N1CCCC(c2ccccc2)C1 CHEMBL605544 IC50 0.8 nM
O=C(NC1C2CC3CC(C2)CC1C3)N1CCC2(CCc3ccccc32)CC1 CHEMBL596621 IC50 0.8 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@](CCC(N)=O)(c3ccccc3)CC2)cc1)C(F)(F)F CHEMBL1642593 IC50 0.8 nM
C[C@@H](c1ccc(-c2ccc(F)cc2F)cc1)N1CC[C@](CCNC(N)=O)(c2ccc(F)cc2)OC1=O CHEMBL1829772 IC50 0.8 nM
O=C1OC(CCO)(c2ccccc2)CCN1c1cccc(-c2ccc(F)cc2F)c1 CHEMBL1829756 IC50 0.8 nM
Cc1c(Cl)cccc1S(=O)(=O)N1CCC[C@H](C(=O)NC2CCCCC2)C1 CHEMBL2334144 IC50 0.8 nM
CN(CC(=O)NC1C2CC3CC1CC(C(N)=O)(C3)C2)S(=O)(=O)N(C)c1c(Cl)cc(Cl)cc1Cl CHEMBL3663668 IC50 0.8 nM
CCn1ccc(-c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)cc1=O CHEMBL3664671 IC50 0.8 nM
COC12CC3CC(C1)C(CC(=O)N1CC(O)C1)(c1ccc(F)cc1)C(C3)C2 CHEMBL4087497 IC50 0.8 nM
C[C@@H](c1ccc(Br)cc1)N1CC[C@](CC(C)(C)C#N)(c2ccc(F)cc2)OC1=O CHEMBL4072907 IC50 0.8 nM
C[C@@H](c1ccc(-c2cccnc2)cc1)N1CC[C@](CCCO)(c2ccccc2)OC1=O CHEMBL4070571 IC50 0.8 nM
C[C@@H](c1ccc(-c2ccc(C#N)cn2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL4090128 IC50 0.8 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](OC(=O)N1CC[C@@H](Nc4ccc(C(F)(F)F)cn4)C1)C(C3)C2 CHEMBL1271320 IC50 0.82 nM
CC(C)(NS(=O)(=O)c1cccc(Cl)c1)C(=O)NC1C2CC3CC1CC(C(N)=O)(C3)C2 CHEMBL3946300 IC50 0.83 nM
C[C@@H](c1ccc(-c2ccc(=O)n(CC3CC3)n2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL3645518 IC50 0.86 nM
CC[C@@H](c1ccc(-c2ccn(C)c(=O)c2)cc1)N1CC[C@](CC)(c2ccccc2)OC1=O CHEMBL3664665 IC50 0.87 nM
CC(C)(C#N)C[C@H]1CC[C@H](N(C(=O)c2ccc([C@](C)(O)C(F)(F)F)cc2)C2CC2)CC1 CHEMBL508331 IC50 0.88 nM
C[C@@H]1CN(CC(F)(F)c2ccncc2)CCN1S(=O)(=O)c1ccc(C(C)(O)C(F)(F)F)cc1 CHEMBL491489 IC50 0.9 nM
O=C(NC1C2CC3CC(C2)CC1C3)N1CCCC(Cc2ccccc2)C1 CHEMBL604589 IC50 0.9 nM
O=C(NC1C2CC3CC(C2)CC1C3)N1CCC(c2ccccc2)CC1 CHEMBL597234 IC50 0.9 nM
C[C@](O)(c1ccc(S(=O)(=O)c2ccc(-c3ccc(C#N)cc3)cc2Cl)cc1)C(F)(F)F CHEMBL1289406 IC50 0.9 nM
C[C@@H](c1ccc(-c2ccc(F)cc2)cc1)N1CC[C@](CCCO)(c2cccc(F)c2)OC1=O CHEMBL1829766 IC50 0.9 nM
C[C@@H](c1ccc(-c2ccc(F)cc2)cc1)N1CC[C@](CCCO)(c2ccccc2F)OC1=O CHEMBL1829765 IC50 0.9 nM
Clc1ccc(C2(c3nnc4c(Oc5ccccc5N5CCOCC5)cccn34)CC2)cc1 CHEMBL3318966 IC50 0.9 nM
NC(=O)c1ccc(N2CCN(c3cccc(C(=O)N[C@H]4C5CC6CC4C[C@](O)(C6)C5)n3)CC2)cc1 CHEMBL3401672 IC50 0.9 nM
C[C@@H](c1ccc(-c2ccn(C)c(=O)c2)cc1)N1CC[C@](CC(C)(C)C#N)(c2ccc(F)cc2)OC1=O CHEMBL3664699 IC50 0.9 nM
NC(=O)C12CC3CC(C1)C(NC(=O)c1cccc(NS(=O)(=O)c4cc(Cl)cc(Cl)c4)c1)C(C3)C2 CHEMBL3920735 IC50 0.9 nM
CC(C)(O)c1cccn2c(C3(c4ccc(Cl)cc4)CC3)nnc12 CHEMBL4301600 Ki 0.9 nM
C[C@@H](c1ccc(-c2ccc(=O)[nH]n2)cc1)N1CC[C@](CC(C)(C)C#N)(c2ccccc2)OC1=O CHEMBL3645530 IC50 0.91 nM
O=C(OC1C2CC3CC(C2)CC1C3)N1CCC[C@@H]1c1nc(-c2ccncc2)cs1 CHEMBL4114230 IC50 0.91 nM
C[C@@H](c1ccc(-c2ccc(=O)n(C)n2)cc1)N1CC[C@](CC(C)(C)C#N)(c2ccccc2)OC1=O CHEMBL3645508 IC50 0.93 nM
C[C@@H](c1ccc(-c2ccn(C)c(=O)c2)cc1)N1CC[C@](CCCO)(c2ccccc2)OC1=O CHEMBL3664716 IC50 0.96 nM
CC(C)n1ccc(-c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)cc1=O CHEMBL3664674 IC50 0.96 nM
Cn1c(-c2ccccc2C(F)(F)F)nnc1-c1ccccc1C(F)(F)F CHEMBL258388 IC50 0.98 nM
Cn1c(-c2ccccc2C(F)(F)F)nnc1-c1cccc2c1ccn2C CHEMBL257779 IC50 0.98 nM
Cn1c(-c2ccccc2Cl)nnc1-c1cccc2c1ccn2C CHEMBL403898 IC50 0.98 nM
Cn1c(-c2ccc(-c3cccc(S(C)(=O)=O)c3)cc2Cl)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL495889 IC50 0.98 nM
CCS(=O)(=O)c1cccc(-c2ccc(-c3nnc(C4(c5ccc(Cl)cc5)CCC4)n3C)c(Cl)c2)c1 CHEMBL521536 IC50 0.98 nM
CCS(=O)(=O)c1ccccc1-c1ccc(-c2nnc(C3(c4ccc(Cl)cc4)CCC3)n2C)c(Cl)c1 CHEMBL496307 IC50 0.98 nM
Cn1c(-c2ccc(-n3ccnc3C(F)(F)F)cc2Cl)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL496714 IC50 0.98 nM
C[C@@H](c1ccc(-c2ccc(F)cc2F)cc1)N1CC[C@](CCC(N)=O)(c2ccc(F)cc2)OC1=O CHEMBL1829777 IC50 0.99 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](OC(=O)N1CC[C@@H](Oc4ccc(C(F)(F)F)cn4)C1)C(C3)C2 CHEMBL4112344 IC50 0.99 nM
Cn1c(-c2ccccc2Br)nnc1-c1ccccc1C(F)(F)F CHEMBL256298 IC50 1.0 nM
Cc1ccc(C2(c3nnc4n3CCCCCC4)CC2)cc1 CHEMBL258447 IC50 1.0 nM
Cc1ccccc1C1(c2nnc3n2CCCCCC3)CCC1 CHEMBL404436 IC50 1.0 nM
Clc1ccc(C2(c3nnc4n3CCCCCC4)CCC2)cc1 CHEMBL257149 IC50 1.0 nM
Fc1ccccc1C1(c2nnc3n2CCCCCC3)CCC1 CHEMBL256720 IC50 1.0 nM
c1ccc(C2(c3nnc4n3CCCCCC4)CCC2)cc1 CHEMBL402552 IC50 1.0 nM
Fc1ccccc1C1(c2nnc3n2CCCCCC3)CCCC1 CHEMBL256291 IC50 1.0 nM
C[C@@H]1CN(CCCc2ccncc2)CCN1S(=O)(=O)c1ccc(C(C)(C)C)cc1 CHEMBL473954 IC50 1.0 nM
Cn1c(-c2ccc(-n3ccnc3)cc2Cl)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL523414 IC50 1.0 nM
Cn1c(-c2ccc(-c3ccccn3)cc2Cl)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL497121 IC50 1.0 nM
Cn1c(-c2ccc(-c3ccncc3)cc2Cl)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL522066 IC50 1.0 nM
Cn1c(-c2ccc(-c3cccnc3)cc2Cl)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL522701 IC50 1.0 nM
Cn1c(-c2ccc(-c3ccccc3)cc2Cl)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL494638 IC50 1.0 nM
Cn1c(-c2ccc(Cl)cc2Cl)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL496095 IC50 1.0 nM
Cn1c(-c2cccc(Cl)c2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL497951 IC50 1.0 nM
Cn1c(-c2cccc(O)c2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL521688 IC50 1.0 nM
O=C(NC1C2CC3CC(C2)CC1C3)[C@H]1CCCN1c1ccccn1 CHEMBL1095785 Ki(app) 1.0 nM
O=C(NC1C2CC3CC(C2)CC1C3)[C@H]1CCCN1CC1CCOCC1 CHEMBL1095786 Ki(app) 1.0 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@](COC(N)=O)(c3ccccc3)CC2)cc1)C(F)(F)F CHEMBL1642595 IC50 1.0 nM
Cn1c(-c2ccccc2C(F)(F)F)nnc1C12CCC(COc3ccc(S(C)(=O)=O)cc3)(CC1)CC2 CHEMBL1761143 IC50 1.0 nM
Cn1c(-c2ccc(C(N)=O)cc2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL1760672 IC50 1.0 nM
C[C@@H](c1ccc(-c2ccc(F)cc2F)cc1)N1CC[C@](CCNS(C)(=O)=O)(c2ccc(F)cc2)OC1=O CHEMBL1829775 IC50 1.0 nM
O=C(c1cccc(CN2C(=O)Nc3ccc(Cl)cc3S2(=O)=O)c1)N(C1CCCCCC1)C1CC1 CHEMBL2023429 EC50 1.0 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](NC(=O)CN1CCCN(c4c(Cl)cc(Cl)cc4Cl)S1(=O)=O)C(C3)C2 CHEMBL2036240 IC50 1.0 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](NC(=O)CN1CCCCN(c4c(Cl)cc(Cl)cc4Cl)S1(=O)=O)C(C3)C2 CHEMBL2036239 IC50 1.0 nM
CN(CC(=O)N[C@H]1C2CC3CC1C[C@](C(N)=O)(C3)C2)S(=O)(=O)N(C)c1c(Cl)cc(Cl)cc1Cl CHEMBL2036232 IC50 1.0 nM
CC1CCN(c2c(Cl)cc(Cl)cc2Cl)S(=O)(=O)N1CC(=O)N[C@H]1C2CC3CC1C[C@](C(N)=O)(C3)C2 CHEMBL2036233 IC50 1.0 nM
CC1CN(CC(=O)N[C@H]2C3CC4CC2C[C@](C(N)=O)(C4)C3)S(=O)(=O)N(c2c(Cl)cc(Cl)cc2Cl)C1 CHEMBL2036234 IC50 1.0 nM
CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C(N)=O)(C3)C2)NS(=O)(=O)c1ccc(F)cc1 CHEMBL3120828 IC50 1.0 nM
CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C(N)=O)(C3)C2)NS(=O)(=O)c1cccc(Cl)c1 CHEMBL3120825 IC50 1.0 nM
CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C(N)=O)(C3)C2)NS(=O)(=O)c1c(F)cc(F)cc1F CHEMBL3120824 IC50 1.0 nM
CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C(N)=O)(C3)C2)NS(=O)(=O)c1cccc(F)c1F CHEMBL3120820 IC50 1.0 nM
CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C(N)=O)(C3)C2)NS(=O)(=O)c1ccc(F)cc1F CHEMBL3120819 IC50 1.0 nM
CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C(N)=O)(C3)C2)NS(=O)(=O)c1cccc(Cl)c1Cl CHEMBL3120818 IC50 1.0 nM
CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C(N)=O)(C3)C2)NS(=O)(=O)c1cccc(Cl)c1F CHEMBL3120817 IC50 1.0 nM
Cc1c(Cl)cccc1S(=O)(=O)NC(C)(C)CC(=O)N[C@H]1C2CC3CC1C[C@](C(N)=O)(C3)C2 CHEMBL3120758 IC50 1.0 nM
NC(=O)[C@]12CC3CC(C[C@@](NC(=O)CN4CCCN(c5c(Cl)cc(Cl)cc5Cl)S4(=O)=O)(C3)C1)C2 CHEMBL3287027 IC50 1.0 nM
Clc1ccc(C2(c3nnc4c(Oc5ccccc5Cl)cccn34)CC2)cc1 CHEMBL3318962 IC50 1.0 nM
CC(C)(NS(=O)(=O)c1cccc(Cl)c1)C(=O)NC1C2CC3CC1CC(C(N)=O)(C3)C2 CHEMBL3609871 IC50 1.0 nM
CC1CN(CC(=O)NC2C3CC4CC2CC(C(N)=O)(C4)C3)S(=O)(=O)N(c2c(Cl)cc(Cl)cc2Cl)C1 CHEMBL3663671 IC50 1.0 nM
Cc1cn2nc(-c3ccc([C@H](C)N4CC[C@](CC(C)(C)O)(c5ccccc5)OC4=O)cc3)ccc2n1 CHEMBL3660134 IC50 1.0 nM
C[C@@H](c1ccc(-c2ccc3nccn3n2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL3660139 IC50 1.0 nM
Cn1cc(-c2ccc(C3(c4nnc5n4CCS[C@@](C)(CO)C5)CC3)cc2)cn1 CHEMBL3681933 IC50 1.0 nM
O=C(CC1(c2ccc(F)cc2)C2CC3CC(C2)CC1C3)N1CCC1 CHEMBL4093016 IC50 1.0 nM
O=C(CC1(c2ccc(F)cc2)C2CC3CC(C2)CC1C3)N1CC(O)C1 CHEMBL4067777 IC50 1.0 nM
COC1CN(C(=O)CC2(c3ccc(F)cc3)C3CC4CC(C3)CC2C4)C1 CHEMBL4078671 IC50 1.0 nM
O=C(CC1(c2ccc(-c3ccncc3)cc2)C2CC3CC1CC(C2)C3O)N1CC(O)C1 CHEMBL4101370 IC50 1.0 nM
Cc1cnc(-c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)cn1 CHEMBL4064441 IC50 1.0 nM
C[C@@H](c1ccc(-c2ccc(=O)n(C)n2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL4063121 IC50 1.0 nM
CC1CN(CC(=O)NC2C3CC4CC2CC(C(N)=O)(C4)C3)S(=O)(=O)N(c2c(Cl)cc(C(F)(F)F)cc2Cl)C1 CHEMBL3951168 IC50 1.0 nM
CC1CN(CC(=O)NC2C3CC4CC2CC(C(N)=O)(C4)C3)S(=O)(=O)N(c2c(Cl)cc(Br)cc2Cl)C1 CHEMBL4633146 IC50 1.0 nM
NC(=O)C12CC3CC(C1)C(NC(=O)CN1CCCN(c4c(Cl)cc(C(F)(F)F)cc4Cl)S1(=O)=O)C(C3)C2 CHEMBL4645319 IC50 1.0 nM
O=C1O[C@]2(CCN(C(=O)C3(c4ccc(Cl)cc4)CC3)C2)c2ccncc21 CHEMBL5202600 IC50 1.0 nM
NC(=O)C12CC3CC(CC(NC(=O)CN4CCCN(c5c(Cl)cc(Cl)cc5Cl)S4(=O)=O)(C3)C1)C2 CHEMBL5280689 IC50 1.0 nM
CCn1cc(-c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)cc(C)c1=O CHEMBL3664676 IC50 1.01 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](OC(=O)N1CC[C@H](n4c(=O)[nH]c5cc(F)ccc54)C1)C(C3)C2 CHEMBL4112976 IC50 1.01 nM
C[C@@H](c1ccc(-c2ccc(=O)n(C)c2)cc1)N1CC[C@](CC(C)(C)C#N)(c2ccccc2)OC1=O CHEMBL3664657 IC50 1.03 nM
CC[C@@H](c1ccc(-c2ccc(=O)n(C)c2)cc1)N1CC[C@](CC)(c2ccccc2)OC1=O CHEMBL3664663 IC50 1.03 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](OC(=O)N1CC[C@@H](n4c(=O)[nH]c5cc(Cl)cnc54)C1)C(C3)C2 CHEMBL4111426 IC50 1.04 nM
C[C@@H](c1ccc(-c2ccc(=O)n(C3CC3)n2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL3645519 IC50 1.08 nM
C[C@@H](c1ccc(-c2ccc(F)cc2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL3645525 IC50 1.08 nM
CC[C@@H](c1ccc(-c2ccc(=O)n(C)c2)cc1)N1CC[C@](CCCO)(c2ccccc2)OC1=O CHEMBL3664654 IC50 1.08 nM
Cn1c(C2CCCN2C(=O)OC2C3CC4CC2CC(C(N)=O)(C4)C3)nc2ccccc21 CHEMBL3944168 IC50 1.08 nM
C[C@@H]1CN(CC(F)(F)c2cccnc2)CCN1S(=O)(=O)c1ccc(C(C)(O)C(F)(F)F)cc1 CHEMBL490953 IC50 1.1 nM
O=C(NC1C2CC3CC(C2)CC1C3)N1CCC(Cc2ccccc2)CC1 CHEMBL603885 IC50 1.1 nM
O=C(O)C[C@H]1CC2(CCN(C(=O)NC3C4CC5CC(C4)CC3C5)CC2)c2c(Br)cccc21 CHEMBL601849 IC50 1.1 nM
Cn1c(-c2ccccc2C(F)(F)F)nnc1C12CCC(COc3ccc(Cl)cc3)(CC1)CC2 CHEMBL1761142 IC50 1.1 nM
Cn1c(-c2ccc(-c3cnoc3)cc2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL1760798 IC50 1.1 nM
C[C@@H](c1ccc(-c2ccc(F)cc2F)cc1)N1CC[C@](CCCO)(c2ccc(F)cc2)OC1=O CHEMBL1829764 IC50 1.1 nM
NC(=O)C12CC3CC(C1)C(NC(=O)c1cccc(NS(=O)(=O)c4cccs4)c1)C(C3)C2 CHEMBL3932816 IC50 1.1 nM
C[C@@H](c1ccc(Br)cc1)N1CC[C@](CCC(N)=O)(c2ccc(F)cc2)OC1=O CHEMBL4099792 IC50 1.1 nM
C[C@@H](c1ccc(-c2ccc(C(N)=O)cn2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL4076599 IC50 1.1 nM
CNC(=O)c1ccc(-c2ccc(C3(C(=O)N4CC[C@@]5(C4)OC(=O)c4ccccc45)CC3)cc2)cn1 CHEMBL5172072 IC50 1.1 nM
C[C@@H](c1ccc(-c2cc[nH]c(=O)c2)cc1)N1CC[C@](CC(C)(C)C#N)(c2ccccc2)OC1=O CHEMBL3664643 IC50 1.11 nM
Cc1nc2cccc(Cl)c2n1[C@H]1CCN(C(=O)OC2C3CC4CC2CC(C(N)=O)(C4)C3)C1 CHEMBL3897514 IC50 1.11 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](OC(=O)N1CCC(c4ncc(Cl)cn4)C1)C(C3)C2 CHEMBL4109384 IC50 1.12 nM
C[C@@H](c1ccc(-c2ccc(=O)n(CC(F)(F)F)n2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL3645515 IC50 1.14 nM
NC(=O)C12CC3CC(C1)C(OC(=O)N1CCC(c4ncc(Cl)cn4)C1)C(C3)C2 CHEMBL3926898 IC50 1.15 nM
O=C(OC1C2CC3CC(C2)CC1C3)N1CCC[C@@H]1c1nc(-c2cc[n+]([O-])cc2)cs1 CHEMBL4114110 IC50 1.19 nM
C[C@@H]1CN(CC2(c3ccc(C(N)=O)cc3)CC2)CCN1S(=O)(=O)c1ccc(C(C)(O)C(F)(F)F)cc1 CHEMBL516636 IC50 1.2 nM
CCCN1CCC[C@@H]1C(=O)NC1C2CC3CC(C2)CC1C3 CHEMBL1088117 IC50 1.2 nM
CCc1ccccc1S(=O)(=O)c1ccc(C(C)(O)C(F)(F)F)cc1 CHEMBL1290057 IC50 1.2 nM
CC(O)(c1ccc(S(=O)(=O)c2ccccc2C2CC2)cc1)C(F)(F)F CHEMBL1290164 IC50 1.2 nM
C[C@](O)(c1ccc(S(=O)(=O)c2ccc(-c3ccc(C#N)cc3)cc2CCF)cc1)C(F)(F)F CHEMBL1289629 IC50 1.2 nM
CC(=O)CCCC12CCC(c3nnc(-c4ccccc4C(F)(F)F)n3C)(CC1)CC2 CHEMBL1761137 IC50 1.2 nM
Cn1c(-c2ccc(-c3cnc(O)nc3)cc2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL1760792 IC50 1.2 nM
Cc1c(Cl)cccc1S(=O)(=O)N1CCCC[C@@H]1C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 CHEMBL3287026 IC50 1.2 nM
C[C@@H](c1ccc(-c2ccn(C3CC3)c(=O)c2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2F)OC1=O CHEMBL3664689 IC50 1.2 nM
CN(CC1(C(=O)NC23CC4CC(CC(C4)C2)C3)CC1)S(=O)(=O)c1ccccc1F CHEMBL3921388 IC50 1.2 nM
CN(C(C)(C)C(=O)NC1C2CC3CC1CC(C(N)=O)(C3)C2)S(=O)(=O)c1ccccc1F CHEMBL3972315 IC50 1.2 nM
Cn1ccc2cc(S(=O)(=O)NCC3(C(=O)NC4C5CC6CC4CC(C(N)=O)(C6)C5)CC3)ccc21 CHEMBL3950121 IC50 1.2 nM
NC(=O)C12CC3CC(C1)C(NC(=O)C1(CNS(=O)(=O)c4ccccc4)CC1)C(C3)C2 CHEMBL3950643 IC50 1.2 nM
C[C@@H](c1ccc(OC(F)F)cc1)N1CC[C@](CC(C)(C)O)(c2ccc(F)cc2)OC1=O CHEMBL4079355 IC50 1.2 nM
Cc1ccc(-c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)nn1 CHEMBL4075178 IC50 1.2 nM
Cc1cc(-c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)cc(C)n1 CHEMBL4072112 IC50 1.2 nM
O=C1O[C@]2(CCN(C(=O)C3(c4ccc(-c5cccnc5)cc4)CC3)C2)c2ccccc21 CHEMBL5203601 IC50 1.2 nM
C#CC(C)(C)C[C@]1(c2ccccc2)CCN([C@@H](C)c2ccc(-c3ccc(=O)n(C(C)C)c3)cc2)C(=O)O1 CHEMBL3664720 IC50 1.21 nM
Cc1cc(-c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)nn(C)c1=O CHEMBL3645516 IC50 1.25 nM
C[C@@H](c1ccc(-c2ccn(C(F)F)c(=O)c2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL3664696 IC50 1.25 nM
CC[C@@H](c1ccc(-c2ccc(=O)n(CC)c2)cc1)N1CC[C@](CC)(c2ccccc2)OC1=O CHEMBL3664664 IC50 1.26 nM
Cc1ccccc1NC1=NC(=O)C(C(C)C)S1 CHEMBL238095 IC50 1.3 nM
Cn1c(-c2ccccc2OC(F)(F)F)nnc1-c1ccccc1C(F)(F)F CHEMBL401909 IC50 1.3 nM
Cn1c(-c2ccc(Cl)cc2Cl)nnc1-c1ccccc1C(F)(F)F CHEMBL403811 IC50 1.3 nM
C[C@@H]1CN(CCc2cccnc2)CCN1S(=O)(=O)c1ccc(C(C)(O)C(F)(F)F)cc1 CHEMBL523444 IC50 1.3 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@H](c3ccccc3)CC2)cc1)C(F)(F)F CHEMBL469699 IC50 1.3 nM
CCN(C(=O)c1ccc([C@](C)(O)C(F)(F)F)cc1)C1CCCCC1 CHEMBL461292 IC50 1.3 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@](CCC(N)=O)(c3ccccc3F)CC2)cc1)C(F)(F)F CHEMBL1642597 IC50 1.3 nM
COC[C@H](C)Oc1nc(C2CC2)c(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)s1 CHEMBL3127865 IC50 1.3 nM
C[C@@H]1CN(CC(=O)NC2C3CC4CC2CC(C(N)=O)(C4)C3)S(=O)(=O)N(c2c(Cl)cc(C(F)(F)F)cc2Cl)C1 CHEMBL3663678 IC50 1.3 nM
C[C@@H](c1ccc(OC(F)F)cc1)N1CC[C@](CCO)(c2ccc(F)cc2)OC1=O CHEMBL3645527 IC50 1.3 nM
C[C@]1(CO)Cc2nnc(C3(c4ccc(-c5cccnc5)cc4)CC3)n2CCS1 CHEMBL3681928 IC50 1.3 nM
Cc1ccc(-c2ccc(C3(c4nnc5n4CCS[C@@](C)(CO)C5)CC3)c(F)c2)nn1 CHEMBL3681938 IC50 1.3 nM
Cc1cc(-c2ccc([C@H](C)N3CC[C@](CCCO)(c4ccccc4)OC3=O)cc2)cc(C)n1 CHEMBL4075665 IC50 1.3 nM
C[C@@H](c1ccc(-c2ccc(=O)n(C)c2)cc1)N1CC[C@](CCCNS(C)(=O)=O)(c2ccccc2)OC1=O CHEMBL3664650 IC50 1.31 nM
CCn1cc(-c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)ccc1=O CHEMBL3664660 IC50 1.35 nM
C[C@@H](c1ccc(-c2ccc(=O)n(C)n2)cc1)N1CC[C@](CC(C)(C)O)(c2ccc(F)cc2)OC1=O CHEMBL3645512 IC50 1.39 nM
C[C@@H](c1ccc(-c2ccc(=O)[nH]c2)cc1)N1CC[C@](CCCO)(c2ccccc2)OC1=O CHEMBL3664709 IC50 1.39 nM
Cn1c(-c2ccccc2C(F)(F)F)nnc1C12CCC(c3nc(-c4ccc(C(O)C(F)(F)F)cc4)no3)(CC1)CC2 CHEMBL372179 IC50 1.4 nM
CNc1c(-c2nnc(-c3ccccc3C(F)(F)F)n2C)ccc2ccccc12 CHEMBL257601 IC50 1.4 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@H](c3cccnc3)CC2)cc1)C(F)(F)F CHEMBL452587 IC50 1.4 nM
O=C(NC1C2CC3CC(C2)CC1C3)N1CCCCC1Cc1ccccc1 CHEMBL605538 IC50 1.4 nM
CCN1CCC[C@@H]1C(=O)NC1C2CC3CC(C2)CC1C3 CHEMBL1095047 Ki(app) 1.4 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@](CC#N)(c3ccccc3)CC2)cc1)C(F)(F)F CHEMBL1642590 IC50 1.4 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@](CC(N)=O)(c3ccccc3)CC2)cc1)C(F)(F)F CHEMBL1642592 IC50 1.4 nM
C[C@@H](c1ccc(-c2ccc(F)cc2F)cc1)N1CC[C@](CCCNC(N)=O)(c2ccc(F)cc2)OC1=O CHEMBL1829780 IC50 1.4 nM
CC(C)N(c1ccc([C@](C)(O)C(F)(F)F)cc1)S(=O)(=O)c1cc(Cl)ccc1Cl CHEMBL2035600 IC50 1.4 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1sc(O[C@@H]2CCCO2)nc1C1CC1 CHEMBL3127866 IC50 1.4 nM
Oc1ccccc1Oc1cccn2c(C3(c4ccc(Cl)cc4)CC3)nnc12 CHEMBL3318968 IC50 1.4 nM
Cc1cc(-c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)cn(C)c1=O CHEMBL3664667 IC50 1.4 nM
C[C@@H](c1ccc(-c2ccn(C3CC3)c(=O)c2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL3664679 IC50 1.4 nM
CCCn1cc(-c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)ccc1=O CHEMBL3664723 IC50 1.4 nM
C[C@@H](c1ccc(-c2ccc3ncnn3c2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL3660140 IC50 1.4 nM
CCN(CC1(C(=O)NC2C3CC4CC2CC(C(N)=O)(C4)C3)CC1)S(=O)(=O)c1ccccc1F CHEMBL3922474 IC50 1.4 nM
C[C@@H](c1ccc(-c2ccc(F)cc2F)cc1)N1CC[C@](CCn2ccnc2)(c2ccc(F)cc2)OC1=O CHEMBL4084288 IC50 1.4 nM
C[C@@H](c1ccc(-c2ccc(=O)n(C)c2)cc1)N1CC[C@](CCCO)(c2ccccc2)OC1=O CHEMBL3664710 IC50 1.4 nM
O=C1O[C@@](CCO)(c2ccccc2)CCN1c1cccc(-c2ccc(F)cc2)n1 CHEMBL3645522 IC50 1.44 nM
C[C@@H](c1ccc(-c2ccn(CC(F)(F)F)c(=O)c2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL3664672 IC50 1.47 nM
C[C@@H](c1ccc(-c2ccc(F)cc2F)cc1)N1CC[C@](CC(C)(C)O)(c2ccc(F)cc2)OC1=O CHEMBL3645523 IC50 1.48 nM
C[C@@H](c1ccc(-c2ccn(C)c(=O)c2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2F)OC1=O CHEMBL3664646 IC50 1.49 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@](C#N)(C3CC3)CC2)cc1)C(F)(F)F CHEMBL518644 IC50 1.5 nM
Cn1c(-c2ccc(F)cc2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL508147 IC50 1.5 nM
CC(C)(C(=O)N1CCC2(CCCCC2)C1)c1ccccc1 CHEMBL565120 IC50 1.5 nM
N#Cc1ccc(N[C@@H]2CCN(C(=O)O[C@H]3C4CC5CC3C[C@](C(N)=O)(C5)C4)C2)nc1 CHEMBL1270001 IC50 1.5 nM
Cn1c(-c2ccc(-c3cncnc3)cc2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL1760691 IC50 1.5 nM
Cn1c(-c2ccc(-c3ccc(Cl)nn3)cc2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL1760796 IC50 1.5 nM
COc1cc(-c2cccnc2)ccc1-c1nnc(C2(c3ccc(Cl)cc3)CCC2)n1C CHEMBL1760803 IC50 1.5 nM
Cc1c(Cl)cccc1S(=O)(=O)N1CCC[C@]1(C)C(=O)NC1C2CC3CC(C2)CC1C3 CHEMBL2152222 IC50 1.5 nM
CC(C)Oc1nc(C2CC2)c(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)s1 CHEMBL3127861 IC50 1.5 nM
C[C@@H]1CN(c2ccc(C(N)=O)cc2)CCN1c1cccc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)n1 CHEMBL3401683 IC50 1.5 nM
O=C(CCO)C12CC3CC(C1)C(NC(=O)C1(CNS(=O)(=O)c4ccccc4F)CC1)C(C3)C2 CHEMBL3894460 IC50 1.5 nM
C[C@@H](c1ccc(-c2ccc(=O)[nH]c2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL3664635 IC50 1.51 nM
CCn1nc(-c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)ccc1=O CHEMBL3645513 IC50 1.52 nM
CC(C)n1cc(-c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)ccc1=O CHEMBL3664718 IC50 1.53 nM
C[C@@H](c1ccc(-c2cc[nH]c(=O)c2)cc1)N1CC[C@](CCCO)(c2ccccc2)OC1=O CHEMBL3664655 IC50 1.58 nM
C[C@@H](c1ccc(-c2ccc(=O)n(C3CC3)c2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL3664694 IC50 1.59 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@@H](c3cccnc3)CC2)cc1)C(F)(F)F CHEMBL455443 IC50 1.6 nM
C=C(c1ccc([C@@](C)(O)C(F)(F)F)cc1)N(C1CC1)[C@H]1CC[C@H](c2ccccn2)CC1 CHEMBL2021495 IC50 1.6 nM
C=C(c1ccc([C@@](C)(O)C(F)(F)F)cc1)N(C1CC1)[C@H]1CC[C@@H](c2ccccn2)CC1 CHEMBL2021496 IC50 1.6 nM
CC(C)n1c(-c2ccc(OC(F)(F)F)cc2)nnc1C1(c2ccc(F)cc2)CC1 CHEMBL476142 IC50 1.6 nM
O=C(O)CC1CC2(CCN(C(=O)NC3C4CC5CC(C4)CC3C5)CC2)c2c(Br)cccc21 CHEMBL605162 IC50 1.6 nM
CC(C)N1CCC[C@@H]1C(=O)NC1C2CC3CC(C2)CC1C3 CHEMBL1095033 Ki(app) 1.6 nM
CCS(=O)(=O)CCCCC12CCC(c3nnc(-c4ccccc4C(F)(F)F)n3C)(CC1)CC2 CHEMBL1761323 IC50 1.6 nM
CC1(c2ccccc2)CCN(c2cccc(-c3ccc(F)cc3F)c2)C(=O)O1 CHEMBL1829754 IC50 1.6 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1cnc(N[C@H]2CCOC2)nc1C1CCCC1 CHEMBL2179014 IC50 1.6 nM
Clc1ccc(C2(c3nnc4c(C5CC5)cccn34)CC2)cc1 CHEMBL3318978 IC50 1.6 nM
CS(=O)(=O)c1ccc(N2CCN(c3cccc(C(=O)N[C@H]4C5CC6CC4C[C@](O)(C6)C5)n3)CC2)cc1 CHEMBL3401671 IC50 1.6 nM
C[C@@H](c1ccc(-c2ccc(=O)n(C)c2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL3664715 IC50 1.6 nM
Cc1ccc(C2CCN(C(=O)OC3C4CC5CC3CC(C(N)=O)(C5)C4)C2)nc1 CHEMBL3922063 IC50 1.61 nM
C[C@@H](c1ccc(-c2ccn(C)c(=O)c2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL3664717 IC50 1.62 nM
Cc1cc(-c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)cc(=O)n1C CHEMBL3664670 IC50 1.64 nM
CC[C@@H](c1ccc(-c2ccn(C)c(=O)c2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL3664662 IC50 1.66 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@H](CC3(C(N)=O)CC3)CC2)cc1)C(F)(F)F CHEMBL454620 IC50 1.7 nM
C[C@@H]1CN(CC2(C(N)=O)CC2)CCN1S(=O)(=O)c1ccc(C(C)(O)C(F)(F)F)cc1 CHEMBL465955 IC50 1.7 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@](C#N)(c3ccccc3)CC2)cc1)C(F)(F)F CHEMBL517760 IC50 1.7 nM
Cn1c(-c2ccc(-c3ccc(S(C)(=O)=O)cc3)cc2Cl)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL497122 IC50 1.7 nM
Cn1c(-c2ccccc2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL523177 IC50 1.7 nM
CC(C)c1cccc(NS(=O)(=O)c2ccc(-c3ccc(C#N)cc3)cc2)n1 CHEMBL495840 Ki 1.7 nM
O=C(NC1C2CC3CC(C2)CC1C3)N1CCC2(CC1)CC(CCO)c1cccc(Br)c12 CHEMBL606420 IC50 1.7 nM
N#Cc1ccc(N[C@H]2CCN(C(=O)O[C@H]3C4CC5CC3C[C@](C(N)=O)(C5)C4)C2)nc1 CHEMBL1270110 IC50 1.7 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@](CNS(C)(=O)=O)(c3ccccc3)CC2)cc1)C(F)(F)F CHEMBL1642594 IC50 1.7 nM
CCOc1nc(C2CC2)c(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)s1 CHEMBL3127860 IC50 1.7 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1sc(OC2CCOCC2)nc1[C@H]1CCCO1 CHEMBL3127858 IC50 1.7 nM
Clc1ccc(C2(c3nnc4c(Oc5ccccc5)cccn34)CC2)cc1 CHEMBL3318961 IC50 1.7 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1cccc(N2CCCCC2)n1 CHEMBL3394399 IC50 1.7 nM
Cc1nc2ccc(-c3ccc([C@H](C)N4CC[C@](CC(C)(C)O)(c5ccccc5)OC4=O)cc3)cn2n1 CHEMBL3660135 IC50 1.7 nM
Cc1ncc(-c2ccc(C3(c4nnc5n4CCS[C@@](C)(CO)C5)CC3)cc2)cn1 CHEMBL3681937 IC50 1.7 nM
Cc1cccc(F)c1S(=O)(=O)NC1(C(=O)NC2C3CC4CC2CC(C(N)=O)(C4)C3)CC1 CHEMBL3966063 IC50 1.7 nM
C[C@@H](c1ccc(Br)cc1)N1CC[C@](CCO)(c2ccc(F)cc2)OC1=O CHEMBL4102254 IC50 1.7 nM
C[C@@H](c1ccc(-c2ncc(C(=O)NC3CC3)s2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL4067153 IC50 1.7 nM
CC1CN(CC(=O)NC2C3CC4CC2CC(C(N)=O)(C4)C3)S(=O)(=O)N(c2ccc(C(F)(F)F)cn2)C1 CHEMBL4649416 IC50 1.7 nM
N#Cc1ccc2c(c1)[nH]c(=O)n2[C@H]1CCN(C(=O)O[C@H]2C3CC4CC2C[C@](C(N)=O)(C4)C3)C1 CHEMBL4114550 IC50 1.71 nM
C[C@@H](c1ccc(-c2ccc(=O)n(C)n2)cc1)N1CC[C@](CCCO)(c2ccccc2)OC1=O CHEMBL3645534 IC50 1.78 nM
C[C@@H](c1ccc(-c2ccc(F)cc2F)cc1)N1CC[C@](CCCNS(C)(=O)=O)(c2ccc(F)cc2)OC1=O CHEMBL1829782 IC50 1.79 nM
Cn1c(-c2ccccc2O)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL494206 IC50 1.8 nM
CC(O)(c1ccc(S(=O)(=O)c2ccc(Br)cc2Cl)cc1)C(F)(F)F CHEMBL1290502 IC50 1.8 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@](CCC(N)=O)(c3ccc(F)cc3)CC2)cc1)C(F)(F)F CHEMBL1642598 IC50 1.8 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@](COC(N)=O)(c3cscn3)CC2)cc1)C(F)(F)F CHEMBL1642603 IC50 1.8 nM
CCCCCC12CCC(c3nnc(-c4ccccc4C(F)(F)F)n3C)(CC1)CC2 CHEMBL383352 IC50 1.8 nM
Cn1c(-c2ccc(-c3cccnc3)cc2F)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL1760802 IC50 1.8 nM
CC(C)N(c1ccc([C@](C)(O)C(F)(F)F)cc1)S(=O)(=O)c1ccccc1Cl CHEMBL2035431 IC50 1.8 nM
O=C(c1cccc(N2CCCCC2)n1)N(C1CC1)[C@H]1CC[C@@H](O)CC1 CHEMBL3394394 IC50 1.8 nM
NC(=O)c1ccc(N2CCN(c3cccc(C(=O)N[C@H]4C5CC6CC4C[C@](O)(C6)C5)n3)CC2)c(Cl)c1 CHEMBL3401676 IC50 1.8 nM
O=C1OC(CCO)(c2ccccc2F)CCN1c1cccc(-c2ccc(F)cc2F)n1 CHEMBL3645521 IC50 1.8 nM
C[C@@H](c1ccc(-c2ccc(=O)n(C(F)F)c2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL3664695 IC50 1.8 nM
CN(C)C(=O)c1cccc(-c2ccc(C3(c4nnc5n4CCSC(C)(CO)C5)CC3)cc2)c1 CHEMBL3681930 IC50 1.8 nM
CC[C@@H](c1ccc(-c2ccc(=O)n(C)c2)cc1)N1CC[C@](CCO)(c2ccccc2)OC1=O CHEMBL3664651 IC50 1.86 nM
Cn1c(-c2ccccc2C(F)(F)F)nnc1C12CCC(c3nc(-c4ccc(S(=O)(=O)C(F)(F)F)cc4)no3)(CC1)CC2 CHEMBL370362 IC50 1.9 nM
COc1c(-c2nnc(-c3ccccc3S(C)(=O)=O)n2C)ccc2ccc(Cl)cc12 CHEMBL401883 IC50 1.9 nM
N#Cc1ccc(-c2ccc(S(=O)(=O)Nc3cccc(C4CC4)n3)cc2)cc1 CHEMBL497105 Ki 1.9 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](OC(=O)N1CC[C@@H](Nc4ccnc(C(F)(F)F)n4)C1)C(C3)C2 CHEMBL1271114 IC50 1.9 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@](CCO)(c3ccccc3)CC2)cc1)C(F)(F)F CHEMBL1642589 IC50 1.9 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1cccc(N2CCC(CO)CC2)n1 CHEMBL3394404 IC50 1.9 nM
C[C@@H](c1ccc(-c2ccc(=O)n(C)n2)cc1)N1CC[C@](CCCO)(c2ccc(F)cc2)OC1=O CHEMBL3645510 IC50 1.9 nM
CN(c1cccc(C(=O)NC2C3CC4CC2CC(C(N)=O)(C4)C3)c1)S(=O)(=O)c1ccccc1C(F)(F)F CHEMBL3927374 IC50 1.9 nM
CC(C1CCCCC1)N1C[C@H](O)C[C@]12CCN(C1CCCCC1)C2=O CHEMBL5208100 IC50 1.9 nM
Cc1nc2cccc(Cl)c2n1[C@@H]1CCN(C(=O)OC2C3CC4CC2CC(C(N)=O)(C4)C3)C1 CHEMBL4107698 IC50 1.92 nM
Cn1ccc(-c2csc(C3CCN(C(=O)O[C@H]4C5CC6CC4C[C@](C(N)=O)(C6)C5)C3)n2)cc1=O CHEMBL4108689 IC50 1.95 nM
Cn1c(=O)ccc2cc(C3CCN(C(=O)OC4C5CC6CC(C5)CC4C6)C3)ccc21 CHEMBL3940236 IC50 1.96 nM
C[C@@H](c1ccc(-c2ccc(=O)n(C)c2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2F)OC1=O CHEMBL3664706 IC50 1.99 nM
Cc1c(-c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)cc(=O)n(C)c1C CHEMBL3664678 IC50 1.99 nM
Cn1c(-c2ccccc2C(F)(F)F)nnc1C12CCC(c3nc(-c4ccc(F)cc4)no3)(CC1)CC2 CHEMBL373257 pIC50 1.995 nM
Cn1c(-c2ccccc2C(F)(F)F)nnc1C12CCC(c3noc(-c4ccc(F)cc4)n3)(CC1)CC2 CHEMBL370657 IC50 2.0 nM
O=C(N[C@H]1C2C[C@H]3CC1C[C@@](O)(C2)C3)C1(N2CCCCC2)CC1 CHEMBL220102 Ki 2.0 nM
CC(C)C1SC(Nc2ccccc2C(F)(F)F)=NC1=O CHEMBL396618 IC50 2.0 nM
Cn1c(-c2ccccc2Cl)nnc1-c1ccccc1Br CHEMBL401908 IC50 2.0 nM
Clc1ccc(C2(c3nnc4n3CCCCCC4)CC2)c(Cl)c1 CHEMBL403993 IC50 2.0 nM
Clc1ccc(C2(c3nnc4n3CCCCCC4)CC2)cc1 CHEMBL258446 IC50 2.0 nM
FC(F)(F)c1ccc(C2(c3nnc4n3CCCCCC4)CCC2)cc1 CHEMBL403201 IC50 2.0 nM
Cc1ccc(C2(c3nnc4n3CCCCCC4)CCC2)cc1 CHEMBL404435 IC50 2.0 nM
Cc1cccc(C2(c3nnc4n3CCCCCC4)CCC2)c1 CHEMBL257148 IC50 2.0 nM
Fc1cccc(C2(c3nnc4n3CCCCCC4)CCC2)c1 CHEMBL255660 IC50 2.0 nM
Cc1ccc(C2(c3nnc4n3CCCCCC4)CCCC2)cc1 CHEMBL256515 IC50 2.0 nM
Clc1ccc(C2(c3nnc4n3CCCCCC4)CCCC2)cc1 CHEMBL255936 IC50 2.0 nM
c1ccc(C2(c3nnc4n3CCCCCC4)CCCC2)cc1 CHEMBL402386 IC50 2.0 nM
CC(C)(C#N)C[C@H]1CC[C@@H](N(C(=O)c2ccc([C@](C)(O)C(F)(F)F)cc2)C2CC2)CC1 CHEMBL523600 IC50 2.0 nM
Cn1c(-c2ccc(O)c(F)c2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL496096 IC50 2.0 nM
Cn1c(-c2ccccc2C(F)(F)F)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL524824 IC50 2.0 nM
Cn1c(-c2ccccc2F)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL496294 IC50 2.0 nM
CCCN(C(=O)c1ccc(CNS(=O)(=O)c2cccc(Cl)c2)cc1)C1CCCCCC1 CHEMBL551949 IC50 2.0 nM
O=C(O)C[C@@H]1CC2(CCN(C(=O)NC3C4CC5CC(C4)CC3C5)CC2)c2c(Br)cccc21 CHEMBL602249 IC50 2.0 nM
CS(=O)(=O)NC(=O)CC1CC2(CCN(C(=O)NC3C4CC5CC(C4)CC3C5)CC2)c2c(Br)cccc21 CHEMBL601210 IC50 2.0 nM
CC(C)COC(=O)N[C@@H]1CCN(C(=O)OC2C3CC4CC(C3)CC2C4)C1 CHEMBL1270408 IC50 2.0 nM
CC(O)(c1ccc(S(=O)(=O)c2ccc(Cl)cc2Cl)cc1)C(F)(F)F CHEMBL1290501 IC50 2.0 nM
NC(=O)C12CC3CC(C1)C(NC(=O)[C@H]1SCCN1S(=O)(=O)c1ccccc1F)C(C3)C2 CHEMBL1642841 IC50 2.0 nM
COCCCCC12CCC(c3nnc(-c4ccccc4C(F)(F)F)n3C)(CC1)CC2 CHEMBL1761140 IC50 2.0 nM
C[C@@H](c1ccc(-c2ccc(F)cc2F)cc1)N1CC[C@](CCNS(N)(=O)=O)(c2ccc(F)cc2)OC1=O CHEMBL1829776 IC50 2.0 nM
N#Cc1c(O)nc(SCc2ccccc2Cl)c2cc(F)ccc12 CHEMBL1911707 IC50 2.0 nM
CCCSc1nc(N2CCC[C@@H](CC(=O)O)C2)ccc1C(=O)NC1CCCCC1 CHEMBL2153191 IC50 2.0 nM
CCCSc1nc(N(C)C)ccc1C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 CHEMBL2158468 IC50 2.0 nM
CC(C)(C)c1c(C(=O)NC2C3CC4CC(C3)CC2C4)cnn1-c1ccc(C(=O)O)cc1 CHEMBL2177609 IC50 2.0 nM
C[C@@H]1CN(c2ccc(C(N)=O)cc2C(F)(F)F)CCN1S(=O)(=O)c1ccc([C@](C)(O)C(F)(F)F)s1 CHEMBL2322708 IC50 2.0 nM
OC1C2CC3CC1CC(C2)C3(Cc1nnn[nH]1)c1ccc(-c2ccccc2F)cc1 CHEMBL3103523 IC50 2.0 nM
COC12CC3CC(C1)C(Cc1nnn[nH]1)(c1ccc(-c4ccccc4)cc1)C(C3)C2 CHEMBL3103439 IC50 2.0 nM
CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C(N)=O)(C3)C2)NS(=O)(=O)c1cccc(F)c1 CHEMBL3120827 IC50 2.0 nM
CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C(N)=O)(C3)C2)NS(=O)(=O)c1ccccc1F CHEMBL3120826 IC50 2.0 nM
CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C(N)=O)(C3)C2)NS(=O)(=O)c1ccc(F)c(F)c1 CHEMBL3120823 IC50 2.0 nM
CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C(N)=O)(C3)C2)NS(=O)(=O)c1c(F)cccc1F CHEMBL3120822 IC50 2.0 nM
COc1ccc(N2CCN(c3cccc(C(=O)N[C@H]4C5CC6CC4C[C@](O)(C6)C5)n3)CC2)cc1 CHEMBL3401668 IC50 2.0 nM
CC(C)(NS(=O)(=O)c1ccccc1)C(=O)NC1C2CC3CC1CC(C(N)=O)(C3)C2 CHEMBL3609870 IC50 2.0 nM
CC(C)(NS(=O)(=O)c1ccc(C(C)(C)C)cc1)C(=O)NC1C2CC3CC1CC(C(N)=O)(C3)C2 CHEMBL3609873 IC50 2.0 nM
CC(C)(NS(=O)(=O)c1ccccc1F)C(=O)NC1C2CC3CC1CC(CO)(C3)C2 CHEMBL3608407 IC50 2.0 nM
Cn1cc(-c2ccc(C3(c4nnc5n4CCSC(C)(CO)C5)CC3)cc2)cn1 CHEMBL3681932 IC50 2.0 nM
N#CC1CN(C(=O)CC2(c3ccc(F)cc3)C3CC4CC(C3)CC2C4)C1 CHEMBL4095204 IC50 2.0 nM
O=C(CC1(c2ccc(F)cc2)C2CC3CC1CC(F)(C3)C2)N1CC(O)C1 CHEMBL4102950 IC50 2.0 nM
N#CC12CC3CC(C1)C(CC(=O)N1CC(O)C1)(c1ccc(F)cc1)C(C3)C2 CHEMBL4060170 IC50 2.0 nM
C[C@@H](c1ccc(OC(F)F)cc1)N1CC[C@](CCC(N)=O)(c2ccc(F)cc2)OC1=O CHEMBL4100755 IC50 2.0 nM
C[C@@H](c1ccc(OC(F)F)cc1)N1CC[C@](CCC(N)=O)(c2ccccc2)OC1=O CHEMBL4076820 IC50 2.0 nM
O=C1N(C2CCCCC2)CC[C@]12C[C@H](F)CN2Cc1ccc(Cl)cc1 CHEMBL5182702 IC50 2.0 nM
CNC(=O)c1ccc(-c2ccc(CN3C[C@@H](F)C[C@]34CCN(C3CCCCC3)C4=O)cc2)cn1 CHEMBL5186299 IC50 2.0 nM
C[C@@H](c1ccc(-c2ccc(=O)n(CC(F)(F)F)c2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL3664673 IC50 2.01 nM
C[C@@H](c1ccc(-c2ccc(=O)[nH]c2)cc1)N1CC[C@](CCO)(c2ccccc2)OC1=O CHEMBL3664714 IC50 2.03 nM
CC(C)(O)CC1(c2ccccc2)CCN(C(=O)O[C@H]2C3CC4CC2C[C@](C(N)=O)(C4)C3)C1 CHEMBL4108116 IC50 2.07 nM
Cn1ccc(-c2csc([C@H]3CCCN3C(=O)O[C@H]3C4CC5CC3C[C@](C(N)=O)(C5)C4)n2)cc1=O CHEMBL4106966 IC50 2.07 nM
Cc1csc(C2CCN(C(=O)OC3C4CC5CC3CC(C(N)=O)(C5)C4)C2)n1 CHEMBL3984060 IC50 2.08 nM
CCS(=O)(=O)c1ccc(-c2ccc(-c3nnc(C4(c5ccc(Cl)cc5)CCC4)n3C)c(Cl)c2)cc1 CHEMBL497555 IC50 2.1 nM
C[C@H]1CCCCN1S(=O)(=O)c1ccc(C(C)(O)C(F)(F)F)cc1 CHEMBL472116 IC50 2.1 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1cccc(N2CCN(c3ccc([N+](=O)[O-])cc3)CC2)n1 CHEMBL3401669 IC50 2.1 nM
CC(C)(NS(=O)(=O)c1ccccc1)C(=O)NC1C2CC3CC1CC(C(N)=O)(C3)C2 CHEMBL3975624 IC50 2.1 nM
C[C@@H]1CN(CCc2ccncc2)CCN1S(=O)(=O)c1ccc(C(C)(O)C(F)(F)F)cc1 CHEMBL473554 IC50 2.2 nM
Cn1c(-c2cccc(F)c2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL496295 IC50 2.2 nM
Cn1c(-c2cccc(OC(F)(F)F)c2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL525606 IC50 2.2 nM
O=C(NC1C2CC3CC(C2)CC1C3)N1CCCCC1c1ccccc1 CHEMBL598039 IC50 2.2 nM
O=C(O)CC1CC2(CCN(C(=O)NC3C4CC5CC(C4)CC3C5)CC2)c2c(Cl)cccc21 CHEMBL602248 IC50 2.2 nM
CCN(CC(=O)NC1C2CC3CC(C2)CC1C3)C1CCCCC1 CHEMBL1088115 IC50 2.2 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@](CO)(c3ccccc3)CC2)cc1)C(F)(F)F CHEMBL1642588 IC50 2.2 nM
CC(=O)NC[C@]1(c2ccccc2)CC[C@H](N(C(=O)c2ccc([C@](C)(O)C(F)(F)F)cc2)C2CC2)CC1 CHEMBL1642596 IC50 2.2 nM
Cn1c(-c2ccc(-c3cnc(N)nc3)cc2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL1760791 IC50 2.2 nM
Cn1c(-c2ccc(C(N)=O)cc2C(N)=O)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL1760808 IC50 2.2 nM
O=C(O)CC1(CCc2ccccc2)C2CC3CC(C2)CC1C3 CHEMBL1911415 IC50 2.2 nM
N#Cc1ccc(N2CCC(c3cccc(C(=O)N[C@H]4C5CC6CC4C[C@](O)(C6)C5)n3)CC2)cc1 CHEMBL3401662 IC50 2.2 nM
C[C@@H]1CN(c2ccc(S(C)(=O)=O)cc2)CCN1c1cccc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)n1 CHEMBL3401681 IC50 2.2 nM
Cn1cc(-c2ccc(C3(c4nnc5n4CCS[C@@](C)(CO)C5)CC3)c(F)c2)cn1 CHEMBL3681936 IC50 2.2 nM
Cc1ccc([C@H](C)N2CC[C@](CCC(N)=O)(c3ccc(F)cc3)OC2=O)cc1 CHEMBL4076033 IC50 2.2 nM
O=C1O[C@]2(CCN(C(=O)C3(c4ccc(-c5ccccc5)nc4)CC3)C2)c2ccccc21 CHEMBL5187458 IC50 2.2 nM
Cc1nc2cc(F)ccc2n1[C@H]1CCN(C(=O)O[C@H]2C3CC4CC2C[C@](C(N)=O)(C4)C3)C1 CHEMBL4113973 IC50 2.22 nM
C[C@@H](c1ccc(-c2ccc(=O)n(C)c2)cc1)N1CC[C@](CCCO)(c2ccc(F)cc2)OC1=O CHEMBL3664712 IC50 2.23 nM
CCn1cc(-c2ccc([C@H](C)N3CC[C@](CCCO)(c4ccccc4)OC3=O)cc2)ccc1=O CHEMBL3664653 IC50 2.23 nM
O=C(OC1C2CC3CC1CC(O)(C3)C2)N1CCC(c2ncc(Cl)cn2)C1 CHEMBL3966788 IC50 2.29 nM
COc1c(-c2nnc(-c3ccccc3C(F)(F)F)n2C)cc(Cl)c2ccccc12 CHEMBL401884 IC50 2.3 nM
Cn1c(-c2ccccc2OC(F)(F)F)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL494809 IC50 2.3 nM
Cn1c(-c2ccc(-c3cnccn3)cc2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL1760794 IC50 2.3 nM
OC1C2CC3CC1CC(C2)C3(Cc1nnn[nH]1)c1ccc(-c2ccc(C(F)(F)F)cc2)cc1 CHEMBL3103525 IC50 2.3 nM
NC(=O)c1ccc(N2CCN(c3cccc(C(=O)N[C@H]4C5CC6CC4C[C@](O)(C6)C5)n3)CC2)cc1F CHEMBL3401674 IC50 2.3 nM
C[C@@H](c1ccc(Cl)cc1)N1CC[C@](CCC(N)=O)(c2ccc(F)cc2)OC1=O CHEMBL4075986 IC50 2.3 nM
COc1ccc(-c2ccc([C@H](C)N3CC[C@](CCCO)(c4ccccc4)OC3=O)cc2)cn1 CHEMBL4066654 IC50 2.3 nM
C[C@@H](c1ccc(-c2ccn(CCF)c(=O)c2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL3664707 IC50 2.34 nM
C[C@@H](c1ccc(-c2ccc(=O)n(C)c2)cc1)N1CC[C@](CC(C)(C)C(N)=O)(c2ccccc2)OC1=O CHEMBL3664697 IC50 2.36 nM
COC(=O)COCC1(c2ccccc2)CCN(C(=O)OC2C3CC4CC(C3)CC2C4)CC1 CHEMBL3896606 IC50 2.39 nM
C[C@@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@H](CCC(N)=O)CC2)cc1)C(F)(F)F CHEMBL2021502 IC50 2.4 nM
CN1CCC[C@@H]1C(=O)NC1C2CC3CC(C2)CC1C3 CHEMBL1088116 Ki(app) 2.4 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@](COC(N)=O)(c3ccc(F)cn3)CC2)cc1)C(F)(F)F CHEMBL1642587 IC50 2.4 nM
Clc1ccc(C2(c3nnc4c(C5CCC5)cccn34)CC2)cc1 CHEMBL3318977 IC50 2.4 nM
N#Cc1ccc(N2CCN(c3cccc(C(=O)N[C@H]4C5CC6CC4C[C@](O)(C6)C5)n3)CC2)nc1 CHEMBL3401659 IC50 2.4 nM
CC[C@@H](c1ccc(-c2ccc(=O)n(C)c2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL3664661 IC50 2.4 nM
CC(C)(NS(=O)(=O)c1ccccc1F)C(=O)NC1C2CC3CC1CC(CO)(C3)C2 CHEMBL3985247 IC50 2.4 nM
CCn1cc(-c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccc(F)cc4)OC3=O)cc2)ccc1=O CHEMBL3664668 IC50 2.48 nM
N#Cc1ccc2c(c1)[nH]c(=O)n2[C@@H]1CCN(C(=O)O[C@H]2C3CC4CC2C[C@](C(N)=O)(C4)C3)C1 CHEMBL4111772 IC50 2.48 nM
Cc1cccc(F)c1S(=O)(=O)NCC1(C(=O)NC2C3CC4CC2CC(C(N)=O)(C4)C3)CC1 CHEMBL3895803 IC50 2.5 nM
Cc1ncc(-c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)cn1 CHEMBL4105041 IC50 2.5 nM
Cn1c(-c2ccccc2C(F)(F)F)nnc1C12CCC(c3nc(-c4ccc(F)cc4F)no3)(CC1)CC2 CHEMBL372851 pIC50 2.57 nM
Cn1c(-c2ccc(F)cc2Cl)nnc1-c1ccccc1C(F)(F)F CHEMBL256986 IC50 2.6 nM
Cc1nccn1-c1ccc(-c2nnc(C3(c4ccc(Cl)cc4)CCC3)n2C)c(Cl)c1 CHEMBL525360 IC50 2.6 nM
C[C@](O)(c1ccc(C(=O)N(CC(F)(F)F)C2CCCCC2)cc1)C(F)(F)F CHEMBL516968 IC50 2.6 nM
N#Cc1cccnc1N[C@H]1CCN(C(=O)O[C@H]2C3CC4CC2C[C@](C(N)=O)(C4)C3)C1 CHEMBL1270002 IC50 2.6 nM
Cn1c(-c2ccc(NC(=O)c3cnccn3)cc2Cl)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL1760690 IC50 2.6 nM
Cc1ccc(-c2ccc(C3(Cc4nnn[nH]4)C4CC5CC3CC(C4)C5O)cc2)cc1 CHEMBL3103524 IC50 2.6 nM
CC1(CO)Cc2nnc(C3(c4ccc(-c5cccnc5)cc4)CC3)n2CCS1 CHEMBL3681926 IC50 2.6 nM
CN(C)C(=O)c1ccc(-c2ccc(C3(c4nnc5n4CCSC(C)(CO)C5)CC3)cc2)cc1 CHEMBL3681929 IC50 2.6 nM
NC(=O)C12CC3CC(C1)C(NC(=O)C1(CNS(=O)(=O)c4cccc(Cl)c4)CC1)C(C3)C2 CHEMBL3934097 IC50 2.6 nM
CC(C)(NS(=O)(=O)c1ccccc1F)C(=O)NC1C2CC3CC1CC(C#N)(C3)C2 CHEMBL3969391 IC50 2.6 nM
O=C(O[C@H]1C2CC3CC1C[C@](O)(C3)C2)N1CC[C@@H](Oc2ccc(C(F)(F)F)cn2)C1 CHEMBL4111928 IC50 2.63 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](OC(=O)N1CCC[C@@H]1c1nc(-c4cc[nH]c(=O)c4)cs1)C(C3)C2 CHEMBL4110101 IC50 2.67 nM
COc1c(-c2nnc(-c3ccccc3C(F)(F)F)n2C)cc2ccccc2c1Cl CHEMBL401975 IC50 2.7 nM
COc1ccccc1-c1nnc(C2(c3ccc(Cl)cc3)CCC2)n1C CHEMBL525003 IC50 2.7 nM
Cn1c(-c2ccc(Cl)cc2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL494819 IC50 2.7 nM
CC(C)(C)OC(=O)N[C@@H]1CCN(C(=O)OC2C3CC4CC(C3)CC2C4)C1 CHEMBL1270215 IC50 2.7 nM
CC(O)(c1ccc(S(=O)(=O)c2ccc(C#N)cc2Cl)cc1)C(F)(F)F CHEMBL1290610 IC50 2.7 nM
C[C@@H](c1ccc(-c2ccc(F)cc2F)cc1)N1CC[C@](CCN)(c2ccc(F)cc2)OC1=O CHEMBL1829770 IC50 2.7 nM
Clc1ccc(C2(c3nnc4c(Oc5ccccc5-c5ccccc5)cccn34)CC2)cc1 CHEMBL3318970 IC50 2.7 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1cccc(N2CCC(O)(C(F)(F)F)CC2)n1 CHEMBL3394400 IC50 2.7 nM
COc1ccc(N2CCN(c3cccc(C(=O)N[C@H]4C5CC6CC4C[C@](O)(C6)C5)n3)[C@H](C)C2)cc1 CHEMBL3401679 IC50 2.7 nM
NC(=O)C12CC3CC(C1)C(OC(=O)N1CCC(c4nccc(C(F)(F)F)n4)C1)C(C3)C2 CHEMBL3902308 IC50 2.7 nM
Cc1c(Cl)cccc1S(=O)(=O)NCC1(C(=O)NC2C3CC4CC2CC(C(N)=O)(C4)C3)CC1 CHEMBL3961594 IC50 2.7 nM
NC(=O)C12CC3CC(C1)C(NC(=O)c1cccc(NS(=O)(=O)c4cccc(Cl)c4F)c1)C(C3)C2 CHEMBL3926948 IC50 2.7 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@@H](CCC#N)CC2)cc1)C(F)(F)F CHEMBL489320 IC50 2.8 nM
CCS(=O)(=O)CCC12CCC(c3nnc(-c4ccc(O)cc4Cl)n3C)(CC1)CC2 CHEMBL1761327 IC50 2.8 nM
Cn1c(-c2ccc(-c3cnccn3)cc2F)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL1760805 IC50 2.8 nM
Clc1cc(Cl)cc(SCc2cccn3c(C4CCCCCC4)nnc23)c1 CHEMBL1800114 IC50 2.8 nM
C[C@@H](c1ccc(-c2ccc(F)cc2F)cc1)N1CC[C@](CC(N)=O)(c2ccc(F)cc2)OC1=O CHEMBL1829769 IC50 2.8 nM
COCCOc1nc(C2CC2)c(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)s1 CHEMBL3127863 IC50 2.8 nM
N#Cc1ccc(N2CCN(c3cccc(C(=O)N[C@H]4C5CC6CC4C[C@](O)(C6)C5)n3)CC2)cc1 CHEMBL3394415 IC50 2.8 nM
C[C@@H](c1ccc(-c2ccc(=O)n(CC(C)(C)C)c2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL3664724 IC50 2.8 nM
Cc1cccc(F)c1S(=O)(=O)N(C)CC1(C(=O)NC2C3CC4CC2CC(C(N)=O)(C4)C3)CC1 CHEMBL3891233 IC50 2.8 nM
CN(C1(C(=O)NC2C3CC4CC2CC(C(N)=O)(C4)C3)CC1)S(=O)(=O)c1ccccc1F CHEMBL3967884 IC50 2.8 nM
CNC(=O)c1ccc(N2CCN(c3cccc(C(=O)NC4C5CC6CC4CC(O)(C6)C5)n3)[C@H](C)C2)cn1 CHEMBL4779054 IC50 2.8 nM
Cn1c(-c2ccccc2Cl)nnc1-c1ccccc1Cl CHEMBL258389 IC50 2.9 nM
Cn1c(-c2cc3ccccc3cc2Cl)nnc1-c1ccccc1C(F)(F)F CHEMBL257129 IC50 2.9 nM
CN(C(=O)OC(C)(C)C)[C@@H]1CCN(C(=O)OC2C3CC4CC(C3)CC2C4)C1 CHEMBL1270503 IC50 2.9 nM
C[C@@H](c1ccc(OC(F)(F)F)cc1)N1CC[C@](CCC(N)=O)(c2ccc(F)cc2)OC1=O CHEMBL4075486 IC50 2.9 nM
C[C@@H]1CN(c2ccc(S(C)(=O)=O)cc2F)CCN1c1nccc(C(=O)NC2C3CC4CC2CC(O)(C4)C3)n1 CHEMBL4748750 IC50 2.9 nM
C[C@@H](c1ccc(-c2ccc(=O)[nH]c2)cc1)N1CC[C@](CC(C)(C)NS(C)(=O)=O)(c2ccccc2)OC1=O CHEMBL3664640 IC50 2.91 nM
C[C@@H](c1ccc(-c2ccc(=O)[nH]c2)cc1)N1CC[C@](CCC(N)=O)(c2ccccc2)OC1=O CHEMBL3664713 IC50 2.97 nM
Cc1cnc(C2CCN(C(=O)OC3C4CC5CC3CC(C(N)=O)(C5)C4)C2)nc1 CHEMBL3909618 IC50 2.99 nM
NC(=O)C12CC3CC(C1)C(OC(=O)N1CCC(c4ncc(F)cn4)C1)C(C3)C2 CHEMBL3914243 IC50 2.99 nM
O=C(CN1CC[C@H](C(F)(F)F)C1)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 CHEMBL375341 Ki 3.0 nM
CC1(C)C(=O)N([C@H]2C3CC4CC2C[C@](C(N)=O)(C4)C3)CC1COc1ccc(C#N)cn1 CHEMBL219049 IC50 3.0 nM
CC(C)C1(C)SC(N[C@@H](C)c2ccccc2F)=NC1=O CHEMBL384653 Ki 3.0 nM
CC(C)(Oc1c(Cl)cc(F)cc1Cl)C(=O)N[C@H]1C2CC3CC1C[C@](S(N)(=O)=O)(C3)C2 CHEMBL391653 Ki 3.0 nM
Fc1ccc(C2(c3nnc4n3CCCCCC4)CCC2)cc1 CHEMBL256514 IC50 3.0 nM
C[C@@H]1CN(c2ccc([N+](=O)[O-])cc2)CCN1S(=O)(=O)c1ccc(C(C)(C)C)cc1 CHEMBL427896 IC50 3.0 nM
CC(C)(C)c1ccc(S(=O)(=O)N2CCCN(c3ncccc3C(F)(F)F)CC2)cc1 CHEMBL430215 IC50 3.0 nM
C[C@@H]1CN(CC2(C(N)=O)CCC2)CCN1S(=O)(=O)c1ccc(C(C)(O)C(F)(F)F)cc1 CHEMBL465956 IC50 3.0 nM
Cn1c(-c2ccc(-n3cccc3)cc2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL524040 IC50 3.0 nM
COc1ccc(-c2nnc(C3(c4ccc(Cl)cc4)CCC3)n2C)cc1F CHEMBL496097 IC50 3.0 nM
O=C1N=C(NC23CC4CC(CC2C4)C3)SC12CCCC2 CHEMBL497552 Ki 3.0 nM
O=C(N1CCC2(CCCCC2)C1)C1(c2ccc(F)cc2)CC1 CHEMBL549539 IC50 3.0 nM
COC1(C)CCCN(S(=O)(=O)c2ccc(C(C)(C)C)cc2)CC1 CHEMBL561274 IC50 3.0 nM
NC(=O)C12CC3CC(C1)C(NC(=O)C1SCCN1S(=O)(=O)c1ccccc1F)C(C3)C2 CHEMBL1642622 IC50 3.0 nM
O=C(O)CC1(c2ccc(F)cc2)C2CCCC1CCC2 CHEMBL1911395 IC50 3.0 nM
N#Cc1ncccc1CSc1nc(O)c(C#N)c2c1CCCC2 CHEMBL1911697 IC50 3.0 nM
N#Cc1c(O)nc(OCc2ccccc2Cl)c2c1CCCC2 CHEMBL1911695 IC50 3.0 nM
O=C(c1cccc(CN2C(=O)Nc3ccc(Cl)cc3S2(=O)=O)c1)N(C1CCCCC1)C1CC1 CHEMBL2023427 EC50 3.0 nM
CCCSc1nc(NC)ccc1C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 CHEMBL2158466 IC50 3.0 nM
CCCSc1c(C(=O)NC2C3CC4CC(C3)CC2C4)cnn1-c1ccc(C(=O)O)cc1 CHEMBL2177615 IC50 3.0 nM
O=S(=O)(c1cccc(-c2ccccc2)n1)N1CCC(c2ccncc2)CC1 CHEMBL3339169 IC50 3.0 nM
NC(=O)C12CC3CC(C1)C(NC(=O)CN1CCCN(c4cccc(F)c4)S1(=O)=O)C(C3)C2 CHEMBL3663665 IC50 3.0 nM
O=C(CC1(c2ccc(F)cc2)C2CC3CC(C2)CC1C3)N1CC(F)(F)C1 CHEMBL4100730 IC50 3.0 nM
Cc1ccc(C2(CC(=O)N3CC(O)C3)C3CC4CC2CC(C3)C4O)cc1 CHEMBL4080314 IC50 3.0 nM
O=C(CC1(c2ccc(Cl)cc2)C2CC3CC1CC(C2)C3O)N1CC(O)C1 CHEMBL4083748 IC50 3.0 nM
O=C(CC1(Cc2ccccc2)C2CC3CC1CC(C2)C3O)N1CC(O)C1 CHEMBL4098342 IC50 3.0 nM
O=C(CC1(c2ccccc2)C2CC3CC1CC(C2)C3O)N1CC(O)C1 CHEMBL4080667 IC50 3.0 nM
CNC(=O)c1ccc(-c2ccc(CN3C[C@H](O)C[C@]34CCN(C3CCCCC3)C4=O)cc2)cn1 CHEMBL5189335 IC50 3.0 nM
CNC(=O)c1ccc(-c2ccc(C3(C(=O)N4CC[C@@]5(C4)OC(=O)c4ccccc45)CC3)cc2)nc1 CHEMBL5175978 IC50 3.0 nM
O=C1O[C@]2(CCN(C(=O)C3(c4ccc(-c5ccccn5)cc4)CC3)C2)c2ccccc21 CHEMBL5188613 IC50 3.0 nM
Cn1c(=O)n([C@@H]2CCN(C(=O)O[C@H]3C4CC5CC3C[C@](C(N)=O)(C5)C4)C2)c2ccccc21 CHEMBL4112407 IC50 3.07 nM
Cn1c(-c2ccccc2Cl)nnc1-c1ccccc1C(F)(F)F CHEMBL256158 IC50 3.1 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](OC(=O)N1CC[C@@H](Nc4cc(C(F)(F)F)ccn4)C1)C(C3)C2 CHEMBL1271319 IC50 3.1 nM
CNC(=O)NCC[C@]1(c2ccc(F)cc2)CCN([C@@H](C)c2ccc(-c3ccc(F)cc3F)cc2)C(=O)O1 CHEMBL1829773 IC50 3.1 nM
Cc1ccccc1S(=O)(=O)N(c1ccc(C(C)(O)C(F)(F)F)cc1)C(C)C CHEMBL2035410 IC50 3.1 nM
CC(C)N(c1ccc(C(C)(O)C(F)(F)F)cc1)S(=O)(=O)c1cc(Cl)ccc1Cl CHEMBL2035413 IC50 3.1 nM
Cc1c(Cl)cccc1S(=O)(=O)N1CCC[C@@]1(C)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 CHEMBL2152227 IC50 3.1 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1cccc(N2CCN(c3ccc(O)cc3)CC2)n1 CHEMBL3394414 IC50 3.1 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1cccc(N2CCN(c3ccc(Cl)cc3)CC2)n1 CHEMBL3401665 IC50 3.1 nM
C[C@@H]1CN(c2ccc(S(C)(=O)=O)cc2)CCN1c1cccc(C(=O)NC2C3CC4CC2CC(O)(C4)C3)n1 CHEMBL4747534 IC50 3.1 nM
COc1cnc(C2CCN(C(=O)OC3C4CC5CC3CC(C(N)=O)(C5)C4)C2)nc1 CHEMBL3891715 IC50 3.11 nM
Cn1c(=O)n([C@H]2CCN(C(=O)O[C@H]3C4CC5CC3C[C@](C(N)=O)(C5)C4)C2)c2ccc(C#N)cc21 CHEMBL4107917 IC50 3.14 nM
C[C@@H](c1ccc(-c2ccc(=O)n(C)c2)cc1)N1CC[C@](CCCNS(C)(=O)=O)(c2ccc(F)cc2)OC1=O CHEMBL3664725 IC50 3.19 nM
CC(O)(c1ccc(S(=O)(=O)c2ccc([N+](=O)[O-])cc2Cl)cc1)C(F)(F)F CHEMBL1290611 IC50 3.2 nM
CCS(=O)(=O)CCCC12CCC(c3nnc(-c4ccccc4C(F)(F)F)n3C)(CC1)CC2 CHEMBL1761322 IC50 3.2 nM
C=CCC1(c2ccccc2)CCN(c2cccc(-c3ccc(F)cc3F)c2)C(=O)O1 CHEMBL1829755 IC50 3.2 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1cccc(N2CCC(O)(c3ccccc3)CC2)n1 CHEMBL3394403 IC50 3.2 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1cccc(N2CCC(O)(C3CC3)CC2)n1 CHEMBL3394402 IC50 3.2 nM
CC[C@@H](c1ccc(-c2ccc(=O)n(CC)c2)cc1)N1CC[C@](CC(C)(C)C#N)(c2ccccc2)OC1=O CHEMBL3903065 IC50 3.24 nM
C[C@@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@](C#N)(c3ccc(F)cc3)CC2)cc1)C(F)(F)F CHEMBL2021499 IC50 3.3 nM
CCc1ccc(S(=O)(=O)N2C[C@@H]3C[C@H]2CN3C)cc1 CHEMBL1076580 IC50 3.3 nM
CCSCCC12CCC(c3nnc(-c4ccccc4C(F)(F)F)n3C)(CC1)CC2 CHEMBL1761311 IC50 3.3 nM
CC1(c2ccccc2)CCN(c2cccc(-c3ccc(F)cc3)c2)C(=O)O1 CHEMBL1829753 IC50 3.3 nM
CC(C)N(c1ccc(C(C)(O)C(F)(F)F)cc1)S(=O)(=O)c1cc(Br)ccc1Cl CHEMBL2035418 IC50 3.3 nM
C[C@]1(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)CCCN1S(=O)(=O)c1ccc(C#N)cc1Cl CHEMBL2152230 IC50 3.3 nM
Cc1c(Br)cccc1C(=O)N1CCC[C@H](c2nc(-c3ccccc3)no2)C1 CHEMBL2334168 IC50 3.3 nM
CC1(CO)Cc2nnc(C3(c4ccc(-c5ccccc5)cc4)CC3)n2CCS1 CHEMBL3681925 IC50 3.3 nM
Cc1ccnc(C2CCN(C(=O)OC3C4CC5CC3CC(C(N)=O)(C5)C4)C2)n1 CHEMBL3900692 IC50 3.34 nM
CC(c1ccncc1)N1CCN(S(=O)(=O)c2ccc(C(C)(C)C)cc2)[C@H](C)C1 CHEMBL473350 IC50 3.4 nM
Cc1cccc2c1C(CC(=O)O)CC21CCN(C(=O)NC2C3CC4CC(C3)CC2C4)CC1 CHEMBL597063 IC50 3.4 nM
O=C(O)CC1CC2(CCN(C(=O)NC3C4CC5CC(C4)CC3C5)CC2)c2ccc(Cl)cc21 CHEMBL605954 IC50 3.4 nM
O=C(O)CC1CC2(CCN(C(=O)NC3C4CC5CC(C4)CC3C5)CC2)c2cc(Cl)ccc21 CHEMBL602051 IC50 3.4 nM
CC(C)(C)OC(=O)N[C@@H]1CCN(C(=O)O[C@H]2C3CC4CC2C[C@](C(N)=O)(C4)C3)C1 CHEMBL1270910 IC50 3.4 nM
CC(C)N(c1ccc(C(C)(O)C(F)(F)F)cc1)S(=O)(=O)c1ccccc1Cl CHEMBL2035400 IC50 3.4 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1cccc(N2CCN(c3ccc(C(F)(F)F)cc3)CC2)n1 CHEMBL3401666 IC50 3.4 nM
C[C@@H](c1ccc(-c2ccn(C)c(=O)c2)cc1)N1CC[C@](CC(C)(C)O)(c2cccc(F)c2)OC1=O CHEMBL3664647 IC50 3.49 nM
Cn1c(-c2ccc(-n3ccnc3)cc2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL494637 IC50 3.5 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@](COC(N)=O)(c3ccccn3)CC2)cc1)C(F)(F)F CHEMBL1642602 IC50 3.5 nM
CC1(C)Cc2c(cnn2-c2ccccc2)C(=O)N([C@H]2C3CC4CC2C[C@@](O)(C4)C3)C1 CHEMBL2338266 IC50 3.5 nM
N#Cc1ccc(C2CCN(c3cccc(C(=O)N[C@H]4C5CC6CC4C[C@](O)(C6)C5)n3)CC2)nc1 CHEMBL3401661 IC50 3.5 nM
C[C@@H]1CN(c2ccc(C#N)cc2)CCN1c1cccc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)n1 CHEMBL3401677 IC50 3.5 nM
C[C@@H]1CN(c2ccc(C(C)(C)O)nc2)CCN1c1cccc(C(=O)NC2C3CC4CC2CC(O)(C4)C3)n1 CHEMBL4746745 IC50 3.5 nM
C[C@@H](c1ccc(-c2ccc(=O)n(C)c2)cc1)N1CC[C@](CC(C)(C)O)(c2ccc(F)cc2)OC1=O CHEMBL3664711 IC50 3.58 nM
Cn1c(-c2ccccc2C(F)(F)F)nnc1-c1cccc(C(F)(F)F)c1C(F)(F)F CHEMBL402737 IC50 3.6 nM
O=C(NC1C2CC3CC(C2)CC1C3)[C@H]1CCCN1CCO CHEMBL1098160 Ki(app) 3.6 nM
Cc1nc([C@H]2CCCO2)c(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)s1 CHEMBL3127874 IC50 3.6 nM
Cc1ccc(N2CCN(c3cccc(C(=O)N[C@H]4C5CC6CC4C[C@](O)(C6)C5)n3)CC2)cc1 CHEMBL3401667 IC50 3.6 nM
Cc1cc2c(cc1C#N)[C@H]1CCCN(C(=O)c3ccc4[nH]cnc4c3)[C@H]1C2 CHEMBL3674424 IC50 3.6 nM
C[C@@H](c1ccc(C(F)(F)F)cc1)N1CC[C@](CCC(N)=O)(c2ccc(F)cc2)OC1=O CHEMBL4066246 IC50 3.6 nM
O=C(O[C@H]1C2CC3CC1C[C@](O)(C3)C2)N1CC[C@@H](Nc2ncc(Cl)cc2[N+](=O)[O-])C1 CHEMBL4110176 IC50 3.69 nM
Cn1c(-c2ccccc2C(F)(F)F)nnc1C12CCC(CCS(=O)(=O)CC(F)(F)F)(CC1)CC2 CHEMBL1761320 IC50 3.7 nM
Cn1c(-c2ccc(-c3cnccn3)cc2OC(F)F)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL1760806 IC50 3.7 nM
Cc1c(Cl)cccc1Oc1cccn2c(C34CCC(CC3)C4)nnc12 CHEMBL1800117 IC50 3.7 nM
O=S(=O)(c1ccc2ccccc2c1)N1CCCN(Cc2c(F)cccc2Cl)CC1 CHEMBL1834084 IC50 3.7 nM
OC1C2CC3CC1CC(C2)C3(Cc1nnn[nH]1)c1ccc(-c2ccc(F)cc2)cc1 CHEMBL3103433 IC50 3.7 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1cccc(N2CCN(c3ccccn3)CC2)n1 CHEMBL3394413 IC50 3.7 nM
O=C(c1cccc(N2CCCCC2)n1)N(C1CC1)[C@H]1CC[C@@](O)(C(F)(F)F)CC1 CHEMBL3394397 IC50 3.7 nM
C[C@@H](c1ccc(-c2ccc(=O)n(C)c2)cc1)N1CC[C@](CC(C)(C)O)(c2cccc(F)c2)OC1=O CHEMBL3664645 IC50 3.7 nM
C=C(C)CC1(c2ccccc2)CCN(C(C)(C)C#Cc2ccc(F)cc2)C(=O)O1 CHEMBL3681944 IC50 3.7 nM
C[C@@H]1CN(c2ccc(C(N)=O)nc2)CCN1c1cccc(C(=O)NC2C3CC4CC2CC(O)(C4)C3)n1 CHEMBL4750382 IC50 3.7 nM
CC(C)(C[C@H]1CC[C@H](N(C(=O)c2ccc([C@](C)(O)C(F)(F)F)cc2)C2CC2)CC1)C(N)=O CHEMBL507804 IC50 3.8 nM
Cn1c(-c2ccc(I)cc2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL498351 IC50 3.8 nM
CC(C)(C)OC(=O)N[C@@H]1CCN(C(=O)O[C@H]2C3CC4CC2C[C@](O)(C4)C3)C1 CHEMBL1270604 IC50 3.8 nM
CC1(C)CCN([C@H]2C3CC4CC2C[C@@](O)(C4)C3)C(=O)c2cnn(-c3ccc(F)cc3)c21 CHEMBL2338251 IC50 3.8 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1cccc(N2CCN(c3ccccc3)CC2)n1 CHEMBL3394412 IC50 3.8 nM
N#Cc1ccc(N2CCC(c3cccc(C(=O)N[C@H]4C5CC6CC4C[C@](O)(C6)C5)n3)CC2)nc1 CHEMBL3401663 IC50 3.8 nM
CNC(=O)c1ccc(N2CCN(c3cccc(C(=O)N[C@H]4C5CC6CC4C[C@](O)(C6)C5)n3)[C@H](C)C2)cc1 CHEMBL3401684 IC50 3.8 nM
CC[C@@H](c1ccc(-c2ccn(C)c(=O)c2)cc1)N1CC[C@](C)(c2ccccc2)OC1=O CHEMBL3664669 IC50 3.85 nM
C[C@@H](c1ccc(-c2ccn(C)c(=O)c2)cc1)N1CC[C@](C[C@](C)(O)CO)(c2ccccc2)OC1=O CHEMBL3664704 IC50 3.89 nM
Cn1c(-c2ccc(O)cc2)nnc1-c1cccc2c1ccn2C CHEMBL257963 IC50 3.9 nM
CSc1nccn1-c1ccc(-c2nnc(C3(c4ccc(Cl)cc4)CCC3)n2C)c(Cl)c1 CHEMBL524623 IC50 3.9 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@](CCC#N)(c3ccccc3)CC2)cc1)C(F)(F)F CHEMBL1642591 IC50 3.9 nM
CN(C)c1cccc2c(S(=O)(=O)N3CCC[C@]3(C)C(=O)N[C@H]3C4CC5CC3C[C@](O)(C5)C4)cccc12 CHEMBL2152238 IC50 3.9 nM
CC1(O)CCN(c2cccc(C(=O)N[C@H]3C4CC5CC3C[C@](O)(C5)C4)n2)CC1 CHEMBL3394401 IC50 3.9 nM
CC(C1CCC1)N1C[C@H](O)C[C@]12CCN(C1CCCCC1)C2=O CHEMBL5183283 IC50 3.9 nM
Cn1c(-c2ccccc2C(F)(F)F)nnc1C12CCC(c3nc(-c4ccc(Cl)cc4)no3)(CC1)CC2 CHEMBL197489 pIC50 3.981 nM
CC(C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2)N1CCc2ccc3c(c2CC1)OCO3 CHEMBL374728 Ki 4.0 nM
C[C@@H](C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2)N1CCN(c2ccc(C(F)(F)F)cn2)CC1 CHEMBL425104 Ki 4.0 nM
Nc1c(Cl)cc(C(=O)N2C3CC4CC(C3)CC2C4)cc1Cl CHEMBL222938 Ki 4.0 nM
CC1(C)CC2CC(C)(CN2C(=O)c2cc(Cl)c(N)c(Cl)c2)C1 CHEMBL376087 Ki 4.0 nM
CC(C)[C@]1(C)SC(N[C@@H](C)c2ccccc2F)=NC1=O CHEMBL221749 Ki 4.0 nM
O=C1N=C(NC23CC4CC(CC(C4)C2)C3)OC12CCCC2 CHEMBL235016 Ki 4.0 nM
CCC1(CC)OC(NC23CC4CC(CC(C4)C2)C3)=NC1=O CHEMBL238234 Ki 4.0 nM
CC(C)(Oc1cccc(Cl)c1)C(=O)N[C@H]1C2CC3CC1C[C@](S(N)(=O)=O)(C3)C2 CHEMBL399191 Ki 4.0 nM
CC(C)(Oc1ccccc1Cl)C(=O)N[C@H]1C2CC3CC1C[C@](S(N)(=O)=O)(C3)C2 CHEMBL239373 Ki 4.0 nM
CC(C)(C)c1ccc(S(=O)(=O)N2CCN(c3ncccc3C(F)(F)F)CC2)cc1 CHEMBL256760 IC50 4.0 nM
C[C@@H]1CN(CCc2ccncc2)CCN1S(=O)(=O)c1ccc(C2(CO)CC2)cc1 CHEMBL489511 IC50 4.0 nM
C[C@@H]1CN(CCc2ccncc2)CCN1S(=O)(=O)c1ccc(C(C)(F)C(F)(F)F)cc1 CHEMBL491152 IC50 4.0 nM
Cc1cccc(NS(=O)(=O)c2ccc(-c3ccc(C#N)cc3)cc2)n1 CHEMBL526098 Ki 4.0 nM
CCCCCC12CCC(c3nnc4n3CCCCCC4)(CC1)CC2 CHEMBL200513 IC50 4.0 nM
CCOCC12CCC(c3nnc(-c4ccccc4C(F)(F)F)n3C)(CC1)CC2 CHEMBL1761141 IC50 4.0 nM
O=C(N1CCC(c2cn[nH]c2)C1)N1CCCc2ccccc21 CHEMBL1761859 IC50 4.0 nM
O=C(O)CC1(c2cccc(Cl)c2)C2CC3CC(C2)CC1C3 CHEMBL1911409 IC50 4.0 nM
O=C(O)CC1(c2ccc(Cl)cc2)C2CC3CC(C2)CC1C3 CHEMBL1911408 IC50 4.0 nM
N#Cc1c(O)nc(SCc2ccccc2Cl)c2ccccc12 CHEMBL1911702 IC50 4.0 nM
N#Cc1c(O)nc(SCc2c(Cl)cccc2Cl)c2c1CCCC2 CHEMBL1911688 IC50 4.0 nM
CN(C(=O)c1cccc(CN2C(=O)Nc3ccc(Cl)cc3S2(=O)=O)c1)C1CCCCCC1 CHEMBL2023428 EC50 4.0 nM
CN(C(=O)c1cccc(CN2C(=O)Nc3ccc(Cl)cc3S2(=O)=O)c1)C1C2CC3CC(C2)CC1C3 CHEMBL2023430 EC50 4.0 nM
O=C(N1CCC(c2c[nH]c3ncccc23)C1)C1(c2ccc(Cl)cc2)CC1 CHEMBL2070229 IC50 4.0 nM
CCCSc1nc(NC)ncc1C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 CHEMBL2158467 IC50 4.0 nM
CCCSc1nc(N(C)C)ncc1C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 CHEMBL2158469 IC50 4.0 nM
CCCSc1nc(N2CCOCC2)ccc1C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 CHEMBL2158470 IC50 4.0 nM
CCSc1c(C(=O)NC2C3CC4CC(C3)CC2C4)cnn1-c1ccc(C(=O)O)cc1 CHEMBL2177620 IC50 4.0 nM
CC(C)(C)N1CCN(c2ccc(N3CCN(C(=O)N[C@H]4C5CC6CC4C[C@](C(N)=O)(C6)C5)c4ccccc43)nc2)CC1 CHEMBL2380648 IC50 4.0 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](NC(=O)N1CCN(c4ccc(N5CCN(S(=O)(=O)C6CC6)CC5)cn4)c4ccccc41)C(C3)C2 CHEMBL2380649 IC50 4.0 nM
CC1(C)OC(N[C@@H](CCO)c2ccccc2Cl)=NS(=O)(=O)C1(C)C CHEMBL2409726 IC50 4.0 nM
C[C@H](NC1=NS(=O)(=O)C(C)(C)C(C)(C)O1)c1ccccc1Cl CHEMBL2409724 IC50 4.0 nM
O=S1(=O)N=C(NC23CC4CC(CC2C4)C3)O[C@H]2CCCC[C@H]21 CHEMBL2409607 IC50 4.0 nM
O=S1(=O)N=C(NC23CC4CC(CC(C4)C2)C3)O[C@H]2CCCC[C@H]21 CHEMBL2409755 IC50 4.0 nM
Cc1c(Cl)cccc1S(=O)(=O)NC(C)(C)CC(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 CHEMBL3120755 IC50 4.0 nM
Cc1c(Cl)cccc1S(=O)(=O)NC(C)(C)CC(=O)NC1C2CC3CC(C2)CC1C3 CHEMBL3120754 IC50 4.0 nM
CSc1nc(N2C[C@@H]3[C@H](C2)[C@H]3C(=O)O)ccc1C(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL3220543 IC50 4.0 nM
Cn1c2c(c(=O)n1Cc1ccccc1C(F)(F)F)[C@H]1CC[C@]2(C)C1(C)C CHEMBL3291357 IC50 4.0 nM
O=C(CC1(c2ccc(C(F)(F)F)cc2)C2CC3CC1CC(C2)C3O)N1CC(O)C1 CHEMBL4076403 IC50 4.0 nM
Cc1cccc(C)c1C1CCN(C(=O)C2(c3ccc(Cl)cc3)CC2)C1 CHEMBL5183831 IC50 4.0 nM
CCn1c(C)cc(-c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)cc1=O CHEMBL3664677 IC50 4.04 nM
COc1ccc(-c2noc(C34CCC(c5nnc(-c6ccccc6C(F)(F)F)n5C)(CC3)CC4)n2)cn1 CHEMBL426835 pIC50 4.074 nM
Cn1c(-c2ccccc2Cl)nnc1C12CCC(c3nc(-c4ccc(F)cc4)no3)(CC1)CC2 CHEMBL200180 IC50 4.1 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@H](F)CC2)cc1)C(F)(F)F CHEMBL471930 IC50 4.1 nM
CC(C)c1ccccc1S(=O)(=O)c1ccc(C(C)(O)C(F)(F)F)cc1 CHEMBL1290163 IC50 4.1 nM
CC[S+]([O-])CCC12CCC(c3nnc(-c4ccccc4C(F)(F)F)n3C)(CC1)CC2 CHEMBL1761312 IC50 4.1 nM
CC(C)S(=O)(=O)CCC12CCC(c3nnc(-c4ccccc4C(F)(F)F)n3C)(CC1)CC2 CHEMBL1761316 IC50 4.1 nM
CNC(=O)NCCC[C@]1(c2ccc(F)cc2)CCN([C@@H](C)c2ccc(-c3ccc(F)cc3F)cc2)C(=O)O1 CHEMBL1829781 IC50 4.1 nM
NC(=O)CCC1CCN(c2cccc(C(=O)N[C@H]3C4CC5CC3C[C@](O)(C5)C4)n2)CC1 CHEMBL3394407 IC50 4.1 nM
C[C@@H]1CN(c2ccc(C(C)(C)O)cc2)CCN1c1cccc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)n1 CHEMBL3401685 IC50 4.1 nM
COc1ccc([C@H](C)N2CC[C@](CCC(N)=O)(c3ccc(F)cc3)OC2=O)cc1 CHEMBL4100648 IC50 4.1 nM
Cn1c(-c2ccccc2C(F)(F)F)nnc1C12CCC(c3nc(-c4cccc(S(C)(=O)=O)c4)no3)(CC1)CC2 CHEMBL198849 pIC50 4.169 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](OC(=O)N1CC[C@@H](n4c(=O)[nH]c5ccccc54)C1)C(C3)C2 CHEMBL4115272 IC50 4.17 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@](O)(CC3CC3)CC2)cc1)C(F)(F)F CHEMBL473347 IC50 4.2 nM
CC1(c2ccccc2)CCN(c2cccc(-c3cccc(F)c3)c2)C(=O)O1 CHEMBL1829752 IC50 4.2 nM
Clc1ccc(C2(c3nnc4c(OC5CCC5)cccn34)CC2)cc1 CHEMBL3318976 IC50 4.2 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1cccc(N2CCN(c3ccc(F)cc3)CC2)n1 CHEMBL3401664 IC50 4.2 nM
C[C@H]1CN(c2ccc(S(C)(=O)=O)cc2)CCN1c1cccc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)n1 CHEMBL3401682 IC50 4.2 nM
O=C1O[C@]2(CCN(C(=O)C3(c4ccc(-c5ccncc5)cc4)CC3)C2)c2ccccc21 CHEMBL5187680 IC50 4.2 nM
C[C@@H](c1ccc(-c2cccc(=O)n2C)cc1)N1CC[C@](CCCO)(c2ccccc2)OC1=O CHEMBL3664656 IC50 4.24 nM
C[C@@H](c1ccc(-c2ccn(CCO)c(=O)c2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL3664703 IC50 4.28 nM
COC(=O)NC(C)(C)C[C@]1(c2ccccc2)CCN([C@@H](C)c2ccc(-c3ccc(=O)n(C)c3)cc2)C(=O)O1 CHEMBL3664639 IC50 4.29 nM
Cn1c(-c2ccccc2C(F)(F)F)nnc1-c1ccc2ccccc2c1F CHEMBL257752 IC50 4.3 nM
Cn1c(-c2cccc(-c3ccccc3)c2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL525924 IC50 4.3 nM
N#Cc1ccc(N2CCN(c3cccc(C(=O)N[C@H]4C5CC6CC4C[C@](O)(C6)C5)n3)CC2)c(Cl)c1 CHEMBL3401675 IC50 4.3 nM
CNS(=O)(=O)c1ccc(N2CCN(c3cccc(C(=O)NC4C5CC6CC4CC(O)(C6)C5)n3)[C@H](C)C2)cc1 CHEMBL4779594 IC50 4.3 nM
CC(C)(C)OC(=O)N[C@H]1CCN(C(=O)O[C@H]2C3CC4CC2C[C@](C(N)=O)(C4)C3)C1 CHEMBL1270911 IC50 4.4 nM
Cc1ccccc1S(=O)(=O)c1ccc(C(C)(O)C(F)(F)F)cc1 CHEMBL1289839 IC50 4.4 nM
Cn1c(-c2ccccc2C(F)(F)F)nnc1C12CCC(CCS(=O)(=O)c3ccccc3)(CC1)CC2 CHEMBL1761318 IC50 4.4 nM
O=C1OC(CCCO)(c2ccccc2)CCN1c1cccc(-c2ccc(F)cc2F)c1 CHEMBL1829757 IC50 4.4 nM
COc1nc(C2CC2)c(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)s1 CHEMBL3127859 IC50 4.4 nM
O=C(OC1C2CC3CC(C2)CC1C3)N1CCC(CO)(c2ccccc2)CC1 CHEMBL3935196 IC50 4.44 nM
Cc1ccc(Cl)c(S(=O)(=O)N(c2ccc(C(C)(O)C(F)(F)F)cc2)C(C)C)c1 CHEMBL2035419 IC50 4.5 nM
C[C@@H]1CN(c2ncc(C(=O)NC3C4CC5CC3CC(O)(C5)C4)c([C@H]3CCCO3)n2)C[C@H](C)O1 CHEMBL3127884 IC50 4.5 nM
COC(=O)Cn1c(=O)n([C@H]2CCN(C(=O)O[C@H]3C4CC5CC3C[C@](C(N)=O)(C5)C4)C2)c2ccc(F)cc21 CHEMBL4112302 IC50 4.52 nM
Cc1ccc2ccccc2c1-c1nnc(-c2ccccc2C(F)(F)F)n1C CHEMBL401830 IC50 4.6 nM
C[C@]1(O)CC[C@@H](N(C(=O)c2cccc(N3CCCCC3)n2)C2CC2)CC1 CHEMBL3394396 IC50 4.6 nM
CN(C)C(=O)c1ccc(-c2ccc(C3(C(=O)N4CC[C@@]5(C4)OC(=O)c4ccccc45)CC3)cc2)cn1 CHEMBL5187093 IC50 4.6 nM
Cn1c(-c2ccccc2C(F)(F)F)cnc1C12CCC(c3nnc(-c4ccc(F)cc4)[nH]3)(CC1)CC2 CHEMBL403283 pIC50 4.677 nM
Cn1c(-c2ccccc2C(F)(F)F)nnc1C12CCC(c3n[nH]c(-c4ccc(F)cc4)n3)(CC1)CC2 CHEMBL198906 IC50 4.7 nM
CC(O)(c1ccc(S(=O)(=O)c2ccccc2Cl)cc1)C(F)(F)F CHEMBL1289838 IC50 4.7 nM
CC1(c2ccccc2)CCN(c2cccc(-c3ccccc3)c2)C(=O)O1 CHEMBL1829750 IC50 4.7 nM
CCNc1cccc(NS(=O)(=O)c2ccc(-c3ccc(C#N)cc3)cc2)n1 CHEMBL489857 Ki 4.8 nM
Cn1c(-c2ccc(-c3ccc(N)nn3)cc2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL1760797 IC50 4.8 nM
Cc1noc(C)c1-c1ccc(-c2nnc(C3(c4ccc(Cl)cc4)CCC3)n2C)cc1 CHEMBL1760799 IC50 4.8 nM
c1ccc(-c2ccc(C3(Cc4nnn[nH]4)C4CC5CC(C4)CC3C5)cc2)cc1 CHEMBL3103437 IC50 4.8 nM
NC(=O)C12CC3CC(C1)C(NC(=O)c1cccc(NS(=O)(=O)c4ccccc4Cl)c1)C(C3)C2 CHEMBL3917341 IC50 4.8 nM
C[C@@H](c1ccc(-c2ccc(F)cc2F)cc1)N1CC[C@](CCN2CCOCC2)(c2ccc(F)cc2)OC1=O CHEMBL4064320 IC50 4.8 nM
CCS(=O)(=O)c1ccc(N2CCN(c3nccc(C(=O)NC4C5CC6CC4CC(O)(C6)C5)n3)[C@H](C)C2)c(F)c1 CHEMBL4746670 IC50 4.8 nM
Cn1c(-c2ccccc2C(F)(F)F)nnc1C12CCC(c3nc(-c4ccc(S(C)(=O)=O)cc4)no3)(CC1)CC2 CHEMBL197220 pIC50 4.898 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@@H](c3ccc(C#N)cc3)CC2)cc1)C(F)(F)F CHEMBL463031 IC50 4.9 nM
O=C(O)CC1(Cc2ccccc2Cl)C2CC3CC(C2)CC1C3 CHEMBL1911413 IC50 4.9 nM
C=C(C)CC1(c2ccccc2)CCN(C(C)(C)C#Cc2ccc3c(ccc(=O)n3C)c2)C(=O)O1 CHEMBL3681940 IC50 4.9 nM
CC(C)NC(=O)c1ccc(-c2ccc(CN3C[C@H](O)C[C@]34CCN(C3CCCCC3)C4=O)cc2F)cn1 CHEMBL5194627 IC50 4.9 nM
CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2CCCC1C[C@@H](C(N)=O)C2 CHEMBL219448 IC50 5.0 nM
CC(C)(Oc1ccc(-n2cccn2)cn1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@@](CC(N)=O)(C2)C3 CHEMBL219348 IC50 5.0 nM
O=C(CN1CCN(c2ccc(Cl)cc2)CC1)NC1C2CC3CC(C2)CC1C3 CHEMBL218093 Ki 5.0 nM
CC(C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2)N1CCN(c2ccc(C(F)(F)F)cn2)CC1 CHEMBL375156 Ki 5.0 nM
CC(C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2)N1CC(Oc2ccccc2F)C1 CHEMBL217917 Ki 5.0 nM
CC1(C)C(=O)N([C@H]2C3CCCC2C[C@@H](C(N)=O)C3)CC1COc1ccc(C#N)cn1 CHEMBL221284 IC50 5.0 nM
CCC(C(=O)N[C@H]1C2CC3CC1C[C@](C(N)=O)(C3)C2)N1CCCC(F)(F)C1 CHEMBL222319 Ki 5.0 nM
CC(C)(Oc1ccccc1Cl)C(=O)N[C@H]1C2CC3CC1C[C@](S(C)(=O)=O)(C3)C2 CHEMBL394217 Ki 5.0 nM
CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2CC3CC1C[C@](S(N)(=O)=O)(C3)C2 CHEMBL392932 Ki 5.0 nM
CC(C)(Oc1ccccc1)C(=O)N[C@H]1C2CC3CC1C[C@](C(N)=O)(C3)C2 CHEMBL429655 IC50 5.0 nM
FC(F)(F)c1ccccc1C1(c2nnc3n2CCCCCC3)CCC1 CHEMBL258448 IC50 5.0 nM
F[C@H]1C[C@](c2ccc(Cl)cc2)(c2nnc(C3CC3)n2C2CC2)C1 CHEMBL404095 IC50 5.0 nM
C[C@@H]1CN(CCc2ccncc2)CCN1S(=O)(=O)c1ccc(C(C)(C)O)cc1 CHEMBL473757 IC50 5.0 nM
Cc1ccccc1-c1nnc(C2(c3ccc(Cl)cc3)CCC2)n1C CHEMBL498352 IC50 5.0 nM
Cc1cccc(C(C)(C)C(=O)NC2C3CC4CC2CC(O)(C4)C3)c1 CHEMBL462305 IC50 5.0 nM
N#Cc1ccc(-c2ccc(S(=O)(=O)Nc3cccc(N)n3)cc2)cc1 CHEMBL495841 EC50 5.0 nM
CC1(O)CCCN(S(=O)(=O)c2ccc(C(C)(C)C)cc2)CC1 CHEMBL564843 IC50 5.0 nM
O=C(OC1C2CC3CC(C2)CC1C3)N1CCCCC1 CHEMBL1269124 IC50 5.0 nM
NC(=O)C12CC3CC(C1)C(NC(=O)C1SCCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)C(C3)C2 CHEMBL1642618 IC50 5.0 nM
COc1cc(-c2nc3sc4c(O)cccc4c3c(=O)n2Cc2ccccc2)c(Br)c(OC)c1OC CHEMBL1650722 IC50 5.0 nM
Cc1ccc(C2(CC(=O)O)C3CC4CC(C3)CC2C4)cc1 CHEMBL1911407 IC50 5.0 nM
N#Cc1c(O)nc(SCc2ccccc2)c2c1-c1ccccc1CC2 CHEMBL1911698 IC50 5.0 nM
N#Cc1c(O)nc(SCc2ccccc2Cl)c2c1CCCC2 CHEMBL1911585 IC50 5.0 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](NC(=O)CN1CC4(CC4)CN(c4c(Cl)cc(Cl)cc4Cl)S1(=O)=O)C(C3)C2 CHEMBL2036236 IC50 5.0 nM
CC1(C)CN(CC(=O)N[C@H]2C3CC4CC2C[C@](C(N)=O)(C4)C3)S(=O)(=O)N(c2c(Cl)cc(Cl)cc2Cl)C1 CHEMBL2036237 IC50 5.0 nM
Cc1[nH]c2ncccc2c1C1CCN(C(=O)C2(c3ccc(F)cc3)CC2)C1 CHEMBL2070319 IC50 5.0 nM
O=C(O)c1ccc(-n2ncc(C(=O)NC3C4CC5CC(C4)CC3C5)c2SC2CCCC2)cc1 CHEMBL2180883 IC50 5.0 nM
CCCSc1c(C(=O)N[C@H]2C3CC4CC2C[C@](OC)(C4)C3)cnn1-c1ccc(C(=O)O)cc1 CHEMBL2177617 IC50 5.0 nM
COc1ccc(-c2cnc(N3CCN(C(=O)N[C@H]4C5CC6CC4C[C@](O)(C6)C5)c4ccccc43)nc2)cc1 CHEMBL2380637 IC50 5.0 nM
N#Cc1ccc(-c2ccc(C3(Cc4nnn[nH]4)C4CC5CC3CC(C4)C5O)cc2)cc1 CHEMBL3103429 IC50 5.0 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1ccc(N2C[C@@H]3[C@H](C2)[C@H]3C(=O)O)nc1SC1CCCC1 CHEMBL3220545 IC50 5.0 nM
O=S(=O)(c1cccc(-c2ccccc2)n1)N1CCC(c2cnco2)CC1 CHEMBL3339176 IC50 5.0 nM
CC1(C)CN(CC(=O)NC2C3CC4CC2CC(C(N)=O)(C4)C3)S(=O)(=O)N(c2c(Cl)cc(Cl)cc2Cl)C1 CHEMBL3663675 IC50 5.0 nM
NC(=O)C12CC3CC(C1)C(NC(=O)CN1CC4(CC4)CN(c4c(Cl)cc(Cl)cc4Cl)S1(=O)=O)C(C3)C2 CHEMBL3663674 IC50 5.0 nM
NC(=O)C12CC3CC(C1)C(NC(=O)c1cccc(NS(=O)(=O)c4c(Cl)cc(Cl)cc4Cl)c1)C(C3)C2 CHEMBL3913245 IC50 5.0 nM
NC(=O)C12CC3CC(C1)C(NC(=O)C1(CNS(=O)(=O)c4cc(Cl)c(Cl)cc4F)CC1)C(C3)C2 CHEMBL3982223 IC50 5.0 nM
O=C(CC1(c2ccc(F)cc2)C2CC3CC1CC(C2)C3O)N1CC(O)C1 CHEMBL4069598 IC50 5.0 nM
CN(C)C(=O)c1ccc(-c2ccc(C3(C(=O)N4CC[C@@]5(C4)OC(=O)c4ccccc45)CC3)cc2)nc1 CHEMBL5194632 IC50 5.0 nM
CC(C)(Oc1ccc(-n2cccn2)cn1)C(=O)N[C@H]1C2CC3CC1C[C@](C(N)=O)(C3)C2 CHEMBL407945 pIC50 5.012 nM
CCCCCC12CCC(c3nnc4n3CCCCC4)(CC1)CC2 CHEMBL402046 pIC50 5.012 nM
C[C@@H](c1ccc(-c2cc(=O)n(C)cn2)cc1)N1CC[C@](CCCO)(c2ccc(F)cc2)OC1=O CHEMBL3645509 IC50 5.02 nM
Cc1nc2cc(C#N)ccc2n1[C@H]1CCN(C(=O)OC2C3CC4CC2CC(C(N)=O)(C4)C3)C1 CHEMBL3973399 IC50 5.03 nM
CCCS(=O)(=O)CCC12CCC(c3nnc(-c4ccccc4C(F)(F)F)n3C)(CC1)CC2 CHEMBL1761315 IC50 5.1 nM
OC12CCC(c3nnc4c(Oc5ccccc5F)cccn34)(CC1)C2 CHEMBL3318981 IC50 5.1 nM
C[C@@H](c1ccc(-c2ccc(=O)n(C)c2)cc1)N1CC[C@](CCC(N)=O)(c2ccccc2)OC1=O CHEMBL3664649 IC50 5.18 nM
CCCCCc1ccc(-c2nnc(-c3ccccc3C(F)(F)F)n2C)cc1 CHEMBL401988 IC50 5.2 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](OC(=O)N1CC[C@@H](Nc4nccc(C(F)(F)F)n4)C1)C(C3)C2 CHEMBL1271010 IC50 5.2 nM
Cn1c(-c2ccccc2C(F)(F)F)cnc1C12CCC(c3nc(-c4ccc(F)cc4)c[nH]3)(CC1)CC2 CHEMBL257059 pIC50 5.248 nM
Cn1c(-c2ccccc2C(F)(F)F)nnc1C12CCC(c3nc(-c4ccc(F)cc4)c[nH]3)(CC1)CC2 CHEMBL370642 IC50 5.3 nM
O=C1N=C(Nc2ccccc2F)SC1C1CCCC1 CHEMBL240269 Ki 5.3 nM
C[C@@H]1CN(CCc2ccncc2)CCN1S(=O)(=O)c1ccc(C(C)(C)C)cc1 CHEMBL515876 IC50 5.3 nM
CC(C)N(c1ccc(C(C)(O)C(F)(F)F)cc1)S(=O)(=O)c1ccccc1[N+](=O)[O-] CHEMBL2035407 IC50 5.3 nM
COc1ccc(N2CCN(c3cccc(C(=O)N[C@H]4C5CC6CC4C[C@](O)(C6)C5)n3)[C@@H](C)C2)cc1 CHEMBL3401680 IC50 5.3 nM
CC(C)(O)CC1(c2ccccc2)CCN(C(C)(C)c2ccc(Br)cc2)C(=O)O1 CHEMBL3681943 IC50 5.3 nM
O=C1OC2(CCN(C(=O)C3(c4ccc(Cl)cc4)CC3)C2)c2ccccc21 CHEMBL5192382 IC50 5.3 nM
C[C@@H](c1ccc(-c2ccc(=O)n(C)c2)cc1)N1CC[C@](CC(C)(C)N(C)S(C)(=O)=O)(c2ccccc2)OC1=O CHEMBL3664642 IC50 5.38 nM
CCCOC(=O)N[C@@H]1CCN(C(=O)OC2C3CC4CC(C3)CC2C4)C1 CHEMBL1270310 IC50 5.4 nM
Cn1c(-c2ccccc2C(F)(F)F)nnc1C12CCC(CCS(=O)(=O)C(C)(C)C)(CC1)CC2 CHEMBL1761317 IC50 5.4 nM
Cc1ccc(-n2ncc3c2C(C)(C)CCN([C@H]2C4CC5CC2C[C@@](O)(C5)C4)C3=O)cc1 CHEMBL2338247 IC50 5.4 nM
CN(C)C(=O)c1ccc(-c2ccc(C3(c4nnc5n4CCSC(C)(CO)C5)CC3)cc2)nc1 CHEMBL3681934 IC50 5.4 nM
C[C@@H](c1ccc(-c2ccn(C)c(=O)c2)cc1)N1CC[C@](CC(C)(C)C(N)=O)(c2ccccc2)OC1=O CHEMBL3664658 IC50 5.46 nM
C[C@@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@H](CC#N)CC2)cc1)C(F)(F)F CHEMBL2021494 IC50 5.5 nM
Cn1c(-c2ccc(-c3cnccn3)cc2Cl)nnc1C1(c2ccc(Cl)cc2)CC(F)C1 CHEMBL1760809 IC50 5.5 nM
Cn1c(-c2ccccc2C(F)(F)F)nnc1C12CCC(CCS(=O)(=O)c3ccc(F)cc3)(CC1)CC2 CHEMBL1760014 IC50 5.5 nM
COC1(c2nnc3c(Oc4cccc(Cl)c4C)cccn23)CCCCCC1 CHEMBL1800118 IC50 5.5 nM
CC(=O)c1ccc(S(=O)(=O)N2CCC[C@]2(C)C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)cc1 CHEMBL2152232 IC50 5.5 nM
Cc1ncccc1Oc1cccn2c(C3(c4ccc(Cl)cc4)CC3)nnc12 CHEMBL3318972 IC50 5.5 nM
N#Cc1ccc(N2CCN(c3cccc(C(=O)N[C@H]4C5CC6CC4C[C@](O)(C6)C5)n3)CC2)cc1F CHEMBL3401673 IC50 5.5 nM
COC12CC3CC(C1)CC(c1nnc4c(Oc5cccc(Cl)c5C)cccn14)(C3)C2 CHEMBL1800119 IC50 5.6 nM
COc1cc2c(cc1C)C[C@H]1[C@@H]2CCCN1C(=O)c1ccc2nc[nH]c2c1 CHEMBL3674422 IC50 5.6 nM
CC(C)(O)CC1(c2ccccc2)CCN(C(C)(C)C#Cc2ccc(F)cc2)C(=O)O1 CHEMBL3681939 IC50 5.6 nM
C[C@@H](c1ccc(-c2ccc(F)cc2F)cc1)N1CC[C@](CCCN)(c2ccc(F)cc2)OC1=O CHEMBL1829779 IC50 5.7 nM
C[C@@H](c1ccc(-c2ccc(=O)n(C)c2)cc1)N1CC[C@](CCO)(c2ccc(F)cc2)OC1=O CHEMBL3664648 IC50 5.7 nM
Cc1cc(C)nc(C2CCN(C(=O)OC3C4CC5CC3CC(C(N)=O)(C5)C4)C2)n1 CHEMBL3923242 IC50 5.72 nM
Cn1c(-c2ccccc2Cl)nnc1-c1ccc(F)cc1Cl CHEMBL404638 IC50 5.8 nM
CC(C)[C@]1(O)CC[C@@H](N(C(=O)c2ccc([C@](C)(O)C(F)(F)F)cc2)C2CC2)CC1 CHEMBL515717 IC50 5.8 nM
Cc1cccc(NS(=O)(=O)c2ccc(-c3ccc(Cl)cc3)cc2)n1 CHEMBL498289 Ki 5.8 nM
CC(C)(C)OC(=O)N[C@@H]1CCN(C(=O)O[C@H]2C3CC4CC2C[C@](CO)(C4)C3)C1 CHEMBL1270807 IC50 5.8 nM
CC(=O)Nc1ccc(-c2nnc(C3(c4ccc(Cl)cc4)CCC3)n2C)cc1 CHEMBL1760683 IC50 5.8 nM
OC(c1cccn2c(C3(c4ccc(Cl)cc4)CC3)nnc12)C1CC1 CHEMBL4457613 IC50 5.9 nM
C[C@@H](c1ccc(-c2ccc(=O)n(C)c2)cc1)N1CC[C@](CC(C)(C)NS(C)(=O)=O)(c2ccccc2)OC1=O CHEMBL3664641 IC50 5.94 nM
CC(C)(Oc1ccc(Br)cn1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@@](CC(N)=O)(C2)C3 CHEMBL437522 IC50 6.0 nM
CO[C@]12CC3CC(C1)[C@@H](NC(=O)C(C)N1CCN(c4ccc(C(F)(F)F)cn4)CC1)C(C3)C2 CHEMBL218144 Ki 6.0 nM
CO[C@]12CC3C[C@](O)(CC(C1)C3NC(=O)C(C)(C)N1CCN(c3ccc(C(F)(F)F)cn3)CC1)C2 CHEMBL219443 Ki 6.0 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](NC(=O)C(C1CC1)N1CCN(c4ccc(C(F)(F)F)cn4)CC1)C(C3)C2 CHEMBL222618 Ki 6.0 nM
CCC(C(=O)N[C@H]1C2CC3CC1C[C@](C(N)=O)(C3)C2)N1CCN(c2ccc(C(F)(F)F)cn2)CC1 CHEMBL374110 Ki 6.0 nM
O=C(N[C@H]1C2C[C@@H]3CC1C[C@](O)(C2)C3)C1(N2CCCCC2)CC1 CHEMBL221159 Ki 6.0 nM
CC(C)C1(C)OC(NC23CC4CC(CC(C4)C2)C3)=NC1=O CHEMBL391188 Ki 6.0 nM
CC(C)C1(C)OC(NC2C3CC4CC(C3)CC2C4)=NC1=O CHEMBL237799 Ki 6.0 nM
CC(C)(Oc1ccc(F)cc1Cl)C(=O)N[C@H]1C2CC3CC1C[C@](S(N)(=O)=O)(C3)C2 CHEMBL391652 Ki 6.0 nM
COc1ccc(OC(C)(C)C(=O)N[C@H]2C3CC4CC2C[C@](C(N)=O)(C4)C3)cc1 CHEMBL394884 IC50 6.0 nM
CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2CC3CC1C[C@](C(N)=O)(C3)C2 CHEMBL245851 IC50 6.0 nM
O=C(N1CCC2(CCCCC2)C1)C1(c2ccc(Cl)cc2)CC1 CHEMBL562614 IC50 6.0 nM
N#Cc1c(O)nc(SCc2ccccc2Cl)c2c(F)cccc12 CHEMBL1911704 IC50 6.0 nM
C=C(C)[C@]1(C)SC(N[C@H]2C[C@@H]3CC[C@H]2C3)=NC1=O CHEMBL2023973 Ki 6.0 nM
CC1(C)[C@@H](O[C@H]2O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]2O[C@@H]2O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]2O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12 CHEMBL441687 IC50 6.0 nM
CC(O)(c1ccc(S(=O)(=O)N2CCC[C@]2(C)C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)cc1)C(F)(F)F CHEMBL2152239 IC50 6.0 nM
CC1(c2c(C(=O)NC3C4CC5CC(C4)CC3C5)cnn2-c2ccc(C(=O)O)cc2)CC1 CHEMBL2177608 IC50 6.0 nM
CCCSc1c(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)cnn1-c1ccc(C(=O)O)cc1 CHEMBL2177616 IC50 6.0 nM
CS(=O)(=O)N1CCN(c2ccc(N3CCN(C(=O)N[C@H]4C5CC6CC4C[C@](C(N)=O)(C6)C5)c4ccccc43)cc2)CC1 CHEMBL2380644 IC50 6.0 nM
CC1(C)OC(N[C@@H](CCO)c2cccc(C#N)c2)=NS(=O)(=O)C1(C)C CHEMBL2409727 IC50 6.0 nM
OC1C2CC3CC1CC(C2)C3(Cc1nnn[nH]1)c1ccc(-c2cccc(F)c2)cc1 CHEMBL3103522 IC50 6.0 nM
CCSc1nc(N2C[C@@H]3[C@H](C2)[C@H]3C(=O)O)ccc1C(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL3220542 IC50 6.0 nM
CCCSc1nc(N2C[C@@H]3[C@H](C2)[C@H]3C(=O)O)ccc1C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 CHEMBL3220544 IC50 6.0 nM
CN(C(=O)c1csc(CNS(=O)(=O)c2cccc(Cl)c2)n1)C1CCCCCC1 CHEMBL3287024 IC50 6.0 nM
NC(=O)C12CC3CC(C1)C(NC(=O)C1(CNS(=O)(=O)c4ccccc4F)CC1)C(C3)C2 CHEMBL3609869 IC50 6.0 nM
CCCSc1nc(N2CCOC(C(=O)O)C2)ccc1C(=O)NC1C2CC3CC(C2)CC1C3 CHEMBL3656460 IC50 6.0 nM
CCSc1nc(N2CC[C@@H](C(=O)O)C2)ccc1C(=O)NC1C2CC3CC(C2)CC1C3 CHEMBL3656461 IC50 6.0 nM
CCSc1nc(N2C[C@@H]3[C@H](C2)[C@H]3C(=O)O)ccc1C(=O)NC1C2CC3CC(C2)CC1C3 CHEMBL3656462 IC50 6.0 nM
CCCSc1nc(N2CCCC(CCC(=O)O)C2)ccc1C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2 CHEMBL4112821 IC50 6.0 nM
CCCCc1nc(N2CCC[C@@H](CC(=O)O)C2)ccc1C(=O)NC1C2CC3CC(C2)CC1C3 CHEMBL3656472 IC50 6.0 nM
O=C1N(C2CCCCC2)CC[C@]12C[C@@H](O)CN2Cc1ccc(Cl)cc1 CHEMBL5172036 IC50 6.0 nM
O=C(N1CC[C@@H](c2ccccc2)C1)C1(c2ccc(Cl)cc2)CC1 CHEMBL5201898 IC50 6.0 nM
CC(C)(Oc1ccc(Br)cn1)C(=O)N[C@H]1C2CC3CC1C[C@](C(N)=O)(C3)C2 CHEMBL257011 pIC50 6.026 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@@H](c3ccccc3)CC2)cc1)C(F)(F)F CHEMBL471750 IC50 6.1 nM
Cn1c(-c2ccccc2C(F)(F)F)nnc1C12CCC(CCS(=O)(=O)C(F)(F)F)(CC1)CC2 CHEMBL1761319 IC50 6.1 nM
C[C@@H](c1ccc(-c2ccn(C3CC3)c(=O)c2)cc1)N1CCC(CC2CC2)(CC(C)(C)O)OC1=O CHEMBL3664691 IC50 6.1 nM
C[C@@H](c1ccc(-c2c[nH]c(=O)cn2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O CHEMBL3645529 IC50 6.16 nM
NC(=O)C12CC3CC(C1)C(NC(=O)C1(CNS(=O)(=O)c4ccccc4F)CC1)C(C3)C2 CHEMBL3964174 IC50 6.2 nM
Cc1c(Cl)cccc1S(=O)(=O)NCC(C)(C)C(=O)NC1C2CC3CC1CC(C(N)=O)(C3)C2 CHEMBL3910251 IC50 6.2 nM
O=C1N=C(Nc2ccccc2Cl)SC1C1CCCC1 CHEMBL240052 Ki 6.3 nM
C[C@@]1(CO)Cc2nnc(C3(c4ccc(-c5cccnc5)cc4)CC3)n2CCS1 CHEMBL3681927 IC50 6.3 nM
Cc1cc(C)n2ncc(C(=O)N[C@H]3C4CC5CC3C[C@](O)(C5)C4)c2n1 CHEMBL3742249 pIC50 6.31 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](OC(=O)N1CC[C@@H](Oc4ccc5nccn5n4)C1)C(C3)C2 CHEMBL4110490 IC50 6.39 nM
CC(C)OC(=O)N[C@@H]1CCN(C(=O)OC2C3CC4CC(C3)CC2C4)C1 CHEMBL1270309 IC50 6.4 nM
Cc1c(Cl)cccc1S(=O)(=O)N1CCC[C@]1(C)C(=O)N[C@H]1CC[C@H](O)CC1 CHEMBL2152220 IC50 6.4 nM
C[C@]1(O)CC[C@H](N(C(=O)c2cccc(N3CCCCC3)n2)C2CC2)CC1 CHEMBL3394395 IC50 6.4 nM
NC(=O)C12CC3CC(C1)C(NC(=O)C1(NS(=O)(=O)c4ccc(F)cc4)CC1)C(C3)C2 CHEMBL3971291 IC50 6.4 nM
CCc1cccc(NS(=O)(=O)c2ccc(-c3ccc(C#N)cc3)cc2)n1 CHEMBL496082 Ki 6.6 nM
CC(C)N(c1ccc(C(C)(O)C(F)(F)F)cc1)S(=O)(=O)c1ccccc1Br CHEMBL2035403 IC50 6.6 nM
NC(=O)CC1CCN(c2cccc(C(=O)N[C@H]3C4CC5CC3C[C@](O)(C5)C4)n2)CC1 CHEMBL3394405 IC50 6.6 nM
C[C@H]1CN(c2ccc(C#N)cc2)CCN1c1cccc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)n1 CHEMBL3401678 IC50 6.6 nM
COC[C@@](C)(O)C[C@]1(c2ccccc2)CCN([C@@H](C)c2ccc(-c3ccn(C)c(=O)c3)cc2)C(=O)O1 CHEMBL3664705 IC50 6.6 nM
O=C1N(C2CCCCC2)CC[C@]12C[C@@H](O)CN2Cc1ccc(-c2ccncc2)cc1 CHEMBL5209448 IC50 6.6 nM
COC(=O)C1(c2ccccc2)CCN(C(=O)OC2C3CC4CC(C3)CC2C4)CC1 CHEMBL3957663 IC50 6.65 nM
Cc1ccc2c(c1)C(CC(=O)O)CC21CCN(C(=O)NC2C3CC4CC(C3)CC2C4)CC1 CHEMBL597481 IC50 6.7 nM
CC1(C)CCN([C@H]2C3CC4CC2C[C@@](O)(C4)C3)C(=O)c2cnn(-c3cccc(F)c3)c21 CHEMBL2338250 IC50 6.7 nM
CCn1cccc(-c2ccc([C@H](C)N3CC[C@](CCCO)(c4ccc(F)cc4)OC3=O)cc2)c1=O CHEMBL3894233 IC50 6.7 nM
CN(C)C(=O)c1ccc(-c2ccc(C3(c4nnc5n4CCS[C@@](C)(CO)C5)CC3)cc2)nc1 CHEMBL3681935 IC50 6.7 nM
NC(=O)C12CC3CC(C1)C(NC(=O)C1(NS(=O)(=O)c4cccc(Cl)c4)CC1)C(C3)C2 CHEMBL3918125 IC50 6.7 nM
O=C(O[C@H]1C2CC3CC1C[C@](C(=O)O)(C3)C2)N1CCCC1c1ccccn1 CHEMBL4111651 IC50 6.74 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1cccc(N2CCN(Cc3ccccc3)CC2)n1 CHEMBL3394409 IC50 6.8 nM
N#Cc1ccc(C2CCN(c3cccc(C(=O)N[C@H]4C5CC6CC4C[C@](O)(C6)C5)n3)CC2)cc1 CHEMBL3401660 IC50 6.8 nM
Cc1cc(C2CCN(C(=O)OC3C4CC5CC3CC(C(N)=O)(C5)C4)C2)nn1C CHEMBL3936016 IC50 6.88 nM
Cc1cn(-c2ccc(-c3nnc(C4(c5ccc(Cl)cc5)CCC4)n3C)c(Cl)c2)c(C)n1 CHEMBL498153 IC50 6.9 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1sc(OC2CCOCC2)nc1C1CC1 CHEMBL3127867 IC50 6.9 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](NC(=O)C1(N4CCN(c5ccc(C(F)(F)F)cn5)CC4)CCC1)C(C3)C2 CHEMBL222511 Ki 7.0 nM
O=C(N[C@H]1C2C[C@H]3CC1C[C@@](C(=O)O)(C2)C3)C1(N2CCN(c3ccc(C(F)(F)F)cn3)CC2)CC1 CHEMBL220883 Ki 7.0 nM
CC(C)C1(C)SC(N[C@@H](C)c2ccccc2Br)=NC1=O CHEMBL221084 Ki 7.0 nM
CC1(C(F)(F)F)OC(NC2C3CC4CC(C3)CC2C4)=NC1=O CHEMBL237798 Ki 7.0 nM
CC(C)[C@H]1SC(Nc2ccccc2F)=NC1=O CHEMBL392452 Ki 7.0 nM
CC(C)(Oc1ccc(F)cc1Cl)C(=O)N[C@H]1C2CC3CC1C[C@](S(C)(=O)=O)(C3)C2 CHEMBL241707 Ki 7.0 nM
CC(C)(Oc1ccccc1OC(F)(F)F)C(=O)N[C@H]1C2CC3CC1C[C@](S(N)(=O)=O)(C3)C2 CHEMBL246858 Ki 7.0 nM
CC(C)(Oc1ccccc1C(F)(F)F)C(=O)N[C@H]1C2CC3CC1C[C@](S(C)(=O)=O)(C3)C2 CHEMBL393167 Ki 7.0 nM
CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2CC3CC1C[C@](S(C)(=O)=O)(C3)C2 CHEMBL241716 Ki 7.0 nM
O=S(=O)(c1ccc(Cl)cc1Cl)N1CCN(c2ncccc2C(F)(F)F)CC1 CHEMBL401787 IC50 7.0 nM
COC1CCCN(S(=O)(=O)c2ccc(C(C)(C)C)cc2)CC1 CHEMBL560396 IC50 7.0 nM
CC(O)(c1ccc(S(=O)(=O)c2ccc(-c3ccncc3)cc2Cl)cc1)C(F)(F)F CHEMBL1290730 IC50 7.0 nM
CCS(=O)(=O)CCC12CCC(c3nnc(-c4ccccc4C(F)(F)F)n3C)(CC1)CC2 CHEMBL1761313 IC50 7.0 nM
O=C(N1CCC(c2cn[nH]c2)C1)N1CCNc2ccccc21 CHEMBL1761863 IC50 7.0 nM
O=C(O)CC1(c2cccc(F)c2)C2CC3CC(C2)CC1C3 CHEMBL1911405 IC50 7.0 nM
N#Cc1ccccc1CSc1nc(O)c(C#N)c2c1CCCC2 CHEMBL1911592 IC50 7.0 nM
O=C(N1CCC(c2c[nH]c3ncccc23)C1)C1(c2ccc(Cl)cc2)CCC1 CHEMBL2070231 IC50 7.0 nM
CCCSc1ncccc1C(=O)N[C@@H]1[C@@H]2CC3C[C@H]1C[C@@](O)(C3)C2 CHEMBL2153178 IC50 7.0 nM
CCCSc1nc(C)ccc1C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 CHEMBL2158464 IC50 7.0 nM
CC1(C)OC(N[C@@H](CCO)c2ccc(F)cc2)=NS(=O)(=O)C1(C)C CHEMBL2409728 IC50 7.0 nM
CC1(C)OC(N[C@@H](CCO)c2ccccc2)=NS(=O)(=O)C1(C)C CHEMBL2409725 IC50 7.0 nM
CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C(N)=O)(C3)C2)NS(=O)(=O)c1cc(F)cc(F)c1 CHEMBL3120821 IC50 7.0 nM
CC(C)[C@]1(C)SC(N[C@H]2C[C@@H]3CC[C@H]2C3)=NC1=O CHEMBL1085107 IC50 7.0 nM
CCCSc1nc(N2C[C@@H]3[C@H](C2)[C@H]3C(=O)O)ccc1C(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL3220541 IC50 7.0 nM
CC1(C)[C@@H]2CC[C@@]1(C)c1c2c(=O)n(-c2ccccc2F)n1Cc1ccccc1 CHEMBL3291344 IC50 7.0 nM
Cn1c2c(c(=O)n1-c1cc(Cl)ccc1Cl)[C@H]1CC[C@]2(C)C1(C)C CHEMBL3291348 IC50 7.0 nM
O=C(N[C@H]1C2CC3CC1C[C@@](O)(C3)C2)c1ccc(N2CCC(C(=O)O)CC2)nc1SC1CCCC1 CHEMBL4107811 IC50 7.0 nM
NC(=O)C12CC3CC(C1)C(CC(=O)N1CC(O)C1)(c1ccc(F)cc1)C(C3)C2 CHEMBL4082055 IC50 7.0 nM
O=C1N(C2CCCCC2)CCC12CCCN2Cc1ccc(C(F)(F)F)cc1 CHEMBL5194187 IC50 7.0 nM
O=C1N(C2CCCCCC2)CCC12CCCN2Cc1ccc(Cl)cc1 CHEMBL5201231 IC50 7.0 nM
O=C1N(C2CCCCC2)CCC12C[C@@H](O)CN2Cc1ccc(Cl)cc1 CHEMBL5178986 IC50 7.0 nM
O=C1N(C2CCCCC2)CC[C@]12C[C@@H](O)CN2CC1CCCCC1 CHEMBL5182029 IC50 7.0 nM
O=C(N1CCC(c2ccncc2)C1)C1(c2ccc(Cl)cc2)CC1 CHEMBL5177277 IC50 7.0 nM
CC(=O)NCC[C@]1(c2ccc(F)cc2)CCN([C@@H](C)c2ccc(-c3ccc(F)cc3F)cc2)C(=O)O1 CHEMBL1829771 IC50 7.1 nM
CC(C)(CNS(=O)(=O)c1cccc(Cl)c1)C(=O)NC1C2CC3CC1CC(C(N)=O)(C3)C2 CHEMBL3984516 IC50 7.1 nM
CCOC(=O)C1(Cc2ccccc2OC)CCCN(C(=O)OC2C3CC4CC(C3)CC2C4)C1 CHEMBL3969809 IC50 7.15 nM
Cn1c(-c2ccccc2C(F)(F)F)nnc1C12CCC(c3nnc(-c4ccc(F)cc4)o3)(CC1)CC2 CHEMBL372945 IC50 7.2 nM
O=C1N=C(Nc2ccccc2F)SC1C1CCCCC1 CHEMBL240053 Ki 7.2 nM
CC(C)C1SC(Nc2ccccc2Cl)=NC1=O CHEMBL235762 Ki 7.2 nM
CC(C)(C)c1ccc(S(=O)(=O)N2CCC[C@]2(C)C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)cc1 CHEMBL2152229 IC50 7.2 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1cccc(N2CCN(Cc3cccnc3)CC2)n1 CHEMBL3394411 IC50 7.2 nM
C[C@@H](c1ccc(-c2cc[nH]c(=O)n2)cc1)N1CC[C@](CCCO)(c2ccc(F)cc2)OC1=O CHEMBL3645532 IC50 7.2 nM
C[C@@H](c1ccc(-c2ccn(C)c(=O)c2)cc1)N1CC[C@](CC(C)(C)NS(C)(=O)=O)(c2ccccc2)OC1=O CHEMBL3664698 IC50 7.22 nM
C[C@@H]1CN(Cc2ccnc3ccccc23)CCN1S(=O)(=O)c1ccc(C(C)(C)C)cc1 CHEMBL473756 IC50 7.3 nM
CC(C)(C)OC(=O)N[C@@H]1CCN(C(=O)O[C@H]2C3CC4CC2C[C@](C#N)(C4)C3)C1 CHEMBL1271009 IC50 7.4 nM
CC(C)N(c1ccc(C(C)(O)C(F)(F)F)cc1)S(=O)(=O)c1ccccc1F CHEMBL2035404 IC50 7.4 nM
NC(=O)[C@]12CC3CC(C1)[C@@H](OC(=O)N1CCCC1c1nc4ccccc4s1)C(C3)C2 CHEMBL4114129 IC50 7.46 nM
C1CCc2nnc(C34CC5CC(CC(C5)C3)C4)n2CC1 CHEMBL256777 IC50 7.5 nM
CC(O)(c1ccc(S(=O)(=O)c2ccccc2C(F)(F)F)cc1)C(F)(F)F CHEMBL1290056 IC50 7.5 nM
CCS(=O)(=O)CCC12CCC(c3nnc(-c4ccccc4Cl)n3C)(CC1)CC2 CHEMBL1761324 IC50 7.5 nM
C[C@@H]1CN(c2cc(F)c(S(C)(=O)=O)cc2F)CCN1c1nccc(C(=O)NC2C3CC4CC2CC(O)(C4)C3)n1 CHEMBL4785894 IC50 7.5 nM
C[C@@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@@H](CC#N)CC2)cc1)C(F)(F)F CHEMBL2021501 IC50 7.6 nM
Cc1cccc2c1C1(CCN(C(=O)NC3C4CC5CC(C4)CC3C5)CC1)CC2CC(=O)O CHEMBL605756 IC50 7.6 nM
C[C@@H]1CN(c2ccc(S(C)(=O)=O)cc2Cl)CCN1c1nccc(C(=O)NC2C3CC4CC2CC(O)(C4)C3)n1 CHEMBL4747303 IC50 7.6 nM
CCCCCc1ccc(-c2nnc(-c3ccccc3Cl)n2C)cc1 CHEMBL428951 IC50 7.7 nM
C[C@]1(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)CCCN1S(=O)(=O)c1cccc2cccnc12 CHEMBL2152237 IC50 7.7 nM
C[C@@H](c1ccc(Br)cc1)N1CC[C@](CC(N)=O)(c2ccc(F)cc2)OC1=O CHEMBL4083350 IC50 7.7 nM
C1CCCn2c(nnc2C23CC4CC(CC(C4)C2)C3)CC1 CHEMBL256778 IC50 7.8 nM
NC(=O)C12CC3CC(C1)C(NC(=O)c1cccc(NS(=O)(=O)c4ccc(F)cc4F)c1)C(C3)C2 CHEMBL3891036 IC50 7.8 nM
C[C@@H]1CN(CC2(C(N)=O)CC2)CCN1S(=O)(=O)c1ccc([C@@](C)(O)C(F)(F)F)cc1 CHEMBL489500 IC50 7.9 nM
CC(C)(Oc1ccccc1Cl)C(=O)N[C@H]1C2CC3CC1C[C@](C(=O)O)(C3)C2 CHEMBL246047 pIC50 7.943 nM
O=C(CN1CCN(c2ccc(C(F)(F)F)cn2)CC1)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 CHEMBL219142 Ki 8.0 nM
CC(C)(C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2)N1CCN(c2ccc(C(F)(F)F)cn2)CC1 CHEMBL424937 Ki 8.0 nM
NC(=O)[C@]12CC3C[C@H](CC(C1)[C@@H]3NC(=O)C1(N3CCN(c4ccc(C(F)(F)F)cn4)CC3)CC1)C2 CHEMBL223804 Ki 8.0 nM
Nc1c(Cl)cc(C(=O)N(C2CCCC2)C2CC2)cc1Cl CHEMBL220795 Ki 8.0 nM
CC(C)C1(C)SC(N[C@@H](C)c2ccccc2Cl)=NC1=O CHEMBL221083 Ki 8.0 nM
CC(C)(C(=O)N[C@H]1C2CC3CC1C[C@](S(N)(=O)=O)(C3)C2)c1ccccc1 CHEMBL391447 Ki 8.0 nM
CNS(=O)(=O)[C@]12CC3CC(C1)[C@@H](NC(=O)C(C)(C)Oc1ccc(Cl)cc1)C(C3)C2 CHEMBL392913 Ki 8.0 nM
CC(C)(Oc1cccc(Cl)c1)C(=O)N[C@H]1C2CC3CC1C[C@](S(C)(=O)=O)(C3)C2 CHEMBL241714 Ki 8.0 nM
CC(C)(Oc1ccc(F)cc1Cl)C(=O)N[C@H]1C2CC3CC1C[C@](S(=O)(=O)CC(N)=O)(C3)C2 CHEMBL241711 Ki 8.0 nM
c1ccc(C2(c3nnc4n3CCCCCC4)CC2)cc1 CHEMBL402995 IC50 8.0 nM
Fc1ccc(C2(c3nnc4n3CCCCCC4)CCCC2)cc1 CHEMBL402613 IC50 8.0 nM
C[C@@H]1CN(CCc2ccncc2)CCN1S(=O)(=O)c1ccc(C2(CN3CCOCC3)CC2)cc1 CHEMBL489707 IC50 8.0 nM
CC(C)c1noc(CC(C)(C)CC(=O)NC2C3CC4CC(C3)CC2C4)n1 CHEMBL552159 IC50 8.0 nM
CC(C)(CC(=O)NC1CC1)CC(=O)N[C@H]1C2CC3CC1C[C@](C(N)=O)(C3)C2 CHEMBL563234 IC50 8.0 nM
CC(C)(CC(=O)NC1CC1)CC(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 CHEMBL550424 IC50 8.0 nM
Cc1ccc(S(=O)(=O)N2CCSC2C(=O)NC2C3CC4CC2CC(C(N)=O)(C4)C3)cc1 CHEMBL1642620 IC50 8.0 nM
Cn1c(-c2ccc(NC(=O)c3ccno3)cc2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL1760687 IC50 8.0 nM
CC1(C)CCN(C(=O)N2CCC(c3cn[nH]c3)C2)c2ccccc21 CHEMBL1761860 IC50 8.0 nM
N#Cc1c(O)nc(OCc2ccccc2Cl)c2cc(F)ccc12 CHEMBL1911709 IC50 8.0 nM
N#Cc1ncccc1CSc1nc(O)c(C#N)c2ccc(F)cc12 CHEMBL1911708 IC50 8.0 nM
N#Cc1c(O)nc(SCc2ccccc2Cl)c2ccc(F)cc12 CHEMBL1911705 IC50 8.0 nM
N#Cc1c(O)nc(SCc2ccccc2Cl)c2cccc(F)c12 CHEMBL1911703 IC50 8.0 nM
CC1(C)CCN([C@H]2C3CC4CC2C[C@@](O)(C4)C3)C(=O)c2cnn(-c3cccc(C(F)(F)F)c3)c21 CHEMBL2338254 IC50 8.0 nM
O=S1(=O)N=C(NC23CCCC2CCC3)O[C@H]2CCCC[C@H]21 CHEMBL2409751 IC50 8.0 nM
COc1ccc(-c2ccc(C3(Cc4nnn[nH]4)C4CC5CC3CC(C4)C5O)cc2)cc1 CHEMBL3103428 IC50 8.0 nM
OC1C2CC3CC1CC(C2)C3(Cc1nnn[nH]1)c1ccc(-c2cccc(C(F)(F)F)c2)cc1 CHEMBL3103427 IC50 8.0 nM
OC12CC3CC(C1)C(Cc1nnn[nH]1)(c1ccc(-c4ccccc4)cc1)C(C3)C2 CHEMBL3103438 IC50 8.0 nM
Cn1c2c(c(=O)n1-c1cccc(I)c1)[C@H]1CC[C@]2(C)C1(C)C CHEMBL3291350 IC50 8.0 nM
Cc1ccc(S(=O)(=O)N(C)C2(C(=O)N[C@H]3C4CC5CC3C[C@](C(N)=O)(C5)C4)CC2)cc1F CHEMBL3741915 IC50 8.0 nM
CCCSc1nc(N2CC[C@H](OCC(=O)O)C2)ccc1C(=O)NC1C2CC3CC(C2)CC1C3 CHEMBL3656459 IC50 8.0 nM
CC1(O)C2CC3CC1CC(C2)C3(CC(=O)N1CC(O)C1)c1ccc(F)cc1 CHEMBL4090613 IC50 8.0 nM
O=C1N(C2CCCCC2)CCC12CCCN2Cc1ccc(Cl)cc1 CHEMBL5196190 IC50 8.0 nM
Cc1ccccc1C1CCN(C(=O)C2(c3ccc(Cl)cc3)CC2)C1 CHEMBL5183130 IC50 8.0 nM
CCCS(=O)(=O)NCC12CCC(c3nnc(-c4ccccc4C(F)(F)F)n3C)(CC1)CC2 CHEMBL1761310 IC50 8.1 nM
N#CC1(COc2nc(C3CC3)c(C(=O)N[C@H]3C4CC5CC3C[C@](O)(C5)C4)s2)CC1 CHEMBL3127869 IC50 8.1 nM
CS(=O)(=O)c1ccccc1Oc1cccn2c(C3(c4ccc(Cl)cc4)CC3)nnc12 CHEMBL3318969 IC50 8.1 nM
Cc1cc(S(C)(=O)=O)ccc1N1CCN(c2nccc(C(=O)NC3C4CC5CC3CC(O)(C5)C4)n2)[C@H](C)C1 CHEMBL4759459 IC50 8.1 nM
Cc1c(Cl)cccc1Oc1cccn2c([C@]34CCC(C[C@H]3O)C4(C)C)nnc12 CHEMBL1800120 IC50 8.2 nM
C[C@]1(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)CCCN1S(=O)(=O)c1ccc(Br)s1 CHEMBL2152236 IC50 8.2 nM
C[C@@H]1CN(c2ccc(C(N)=O)cc2)CCN1c1cccc(C(=O)NC2C3CC4CC2CC(O)(C4)C3)n1 CHEMBL4742750 IC50 8.2 nM
Cc1nc(OCC(F)(F)F)c(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)s1 CHEMBL3127891 IC50 8.3 nM
O=C(NC1CC2CCC1C2)C1(NS(=O)(=O)c2cccc(Cl)c2)CC1 CHEMBL3986140 IC50 8.3 nM
C[C@]1(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)CCCN1S(=O)(=O)c1ccccc1C#N CHEMBL2152231 IC50 8.4 nM
Cc1c(Cl)cccc1Oc1cccn2c(C34CCC(F)(CC3)CC4)nnc12 CHEMBL1800133 IC50 8.5 nM
O=C(CC1(c2ccc(F)cc2)C2CC3CC1CC(C2)C3O)N1CC(O)C1 CHEMBL4073762 IC50 8.5 nM
C[C@@H]1CN(c2ccc(S(C)(=O)=O)cc2)CCN1c1nccc(C(=O)NC2C3CC4CC2CC(O)(C4)C3)n1 CHEMBL4788862 IC50 8.5 nM
COc1cc(O)ccc1-c1nnc(C23CCC(c4nc(-c5ccc(F)cc5)no4)(CC2)CC3)n1C CHEMBL373034 pIC50 8.511 nM
CC1(C)[C@@H](O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12 CHEMBL230006 IC50 8.6 nM
Cn1c(-c2ccc(NC(=O)c3cccs3)cc2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL1760685 IC50 8.7 nM
O=C(O)CCC1CCN(c2cccc(C(=O)N[C@H]3C4CC5CC3C[C@](O)(C5)C4)n2)CC1 CHEMBL3394408 IC50 8.7 nM
Nc1ccc(N2CCN(c3cccc(C(=O)N[C@H]4C5CC6CC4C[C@](O)(C6)C5)n3)CC2)cc1 CHEMBL3401670 IC50 8.7 nM
Cn1c(-c2ccc(-c3cc(O)ncn3)cc2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL1760795 IC50 8.8 nM
C[C@@H]1CN(c2ccc(C(C)(C)O)cc2F)CCN1c1nccc(C(=O)NC2C3CC4CC2CC(O)(C4)C3)n1 CHEMBL4762396 IC50 8.8 nM
CC(C)[C@]1(CCCO)CCN([C@@H](C)c2ccc(-c3ccn(C)c(=O)c3)cc2)C(=O)O1 CHEMBL3664708 IC50 8.89 nM
Cc1ccc2c(c1)C1(CCN(C(=O)NC3C4CC5CC(C4)CC3C5)CC1)CC2CC(=O)O CHEMBL597676 IC50 8.9 nM
CC1(C)CCN([C@H]2C3CC4CC2C[C@@](O)(C4)C3)C(=O)c2cnn(-c3ccccc3)c21 CHEMBL2338264 IC50 8.9 nM
CC(C)(CNS(=O)(=O)c1ccccc1F)C(=O)NC1C2CC3CC1CC(C(N)=O)(C3)C2 CHEMBL3983618 IC50 8.9 nM
CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2CC3CC1C[C@](CO)(C3)C2 CHEMBL246676 pIC50 8.913 nM
CC(C)(C(=O)N[C@H]1C2C[C@H]3CC1C[C@@](C(N)=O)(C2)C3)N1CCN(c2ccc(C(F)(F)F)cn2)CC1 CHEMBL222670 Ki 9.0 nM
CC(C)[C@@]1(C)SC(N[C@@H](C)c2ccccc2F)=NC1=O CHEMBL221477 Ki 9.0 nM
Cc1ccc2ccc(-c3nnc(-c4ccccc4C(F)(F)F)n3C)cc2c1 CHEMBL403758 IC50 9.0 nM
C[C@H]1CN(c2ncccc2C(F)(F)F)CCN1S(=O)(=O)c1ccc(C(C)(C)C)cc1 CHEMBL256927 IC50 9.0 nM
CC1CN(c2ncccc2C(F)(F)F)CCN1S(=O)(=O)c1ccc(C(C)(C)C)cc1 CHEMBL257567 IC50 9.0 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@](O)(c3ccccc3)CC2)cc1)C(F)(F)F CHEMBL460933 IC50 9.0 nM
CC(O)(c1ccc(C(=O)N(CC2CC2)C2CCCCC2)cc1)C(F)(F)F CHEMBL444567 IC50 9.0 nM
COc1ccccc1NC(=O)CC1(CC(=O)NC2C3CC4CC(C3)CC2C4)CCCC1 CHEMBL562113 IC50 9.0 nM
CC(C)CNC(=O)CC1(CC(=O)NC2C3CC4CC(C3)CC2C4)CCCC1 CHEMBL549419 IC50 9.0 nM
O=C(N[C@@H]1CCN(C(=O)OC2C3CC4CC(C3)CC2C4)C1)OCc1ccccc1 CHEMBL1270409 IC50 9.0 nM
CC(O)(c1ccc(S(=O)(=O)c2ccc(CC3(C#N)CC3)cc2Cl)cc1)C(F)(F)F CHEMBL1289178 IC50 9.0 nM
CN1CCN(C(=O)N2CCC(c3cn[nH]c3)C2)c2ccccc21 CHEMBL1761864 IC50 9.0 nM
N#Cc1c(O)nc(SCC2CCC2)c2c1CCCC2 CHEMBL1911696 IC50 9.0 nM
CCCSc1ncncc1C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 CHEMBL2158007 IC50 9.0 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1cnc(NC2COC2)nc1C1CCCC1 CHEMBL2179456 IC50 9.0 nM
O=C(O)c1ccc(-n2ncc(C(=O)NC3C4CC5CC(C4)CC3C5)c2C2CCCC2)cc1 CHEMBL2177606 IC50 9.0 nM
COc1ccc(-c2cnc(N3CCN(C(=O)N[C@H]4C5CC6CC4C[C@](OC(N)=O)(C6)C5)c4ccccc43)nc2)cc1 CHEMBL2380640 IC50 9.0 nM
CC(C)(C)N1CCN(c2ccc(N3CCN(C(=O)N[C@H]4C5CC6CC4C[C@](O)(C6)C5)c4ccccc43)nc2)CC1 CHEMBL2380645 IC50 9.0 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)N1CCN(c2ccc(N3CCN(S(=O)(=O)C4CC4)CC3)cn2)c2ccccc21 CHEMBL2380647 IC50 9.0 nM
COC[C@@H](C)Oc1nc(C2CC2)c(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)s1 CHEMBL3127864 IC50 9.0 nM
CCn1c2c(c(=O)n1-c1ccccc1)[C@H]1CC[C@]2(C)C1(C)C CHEMBL3291339 IC50 9.0 nM
CC1(C)[C@@H]2CC[C@@]1(C)c1c2c(=O)n(-c2ccc(F)cc2F)n1Cc1ccccc1 CHEMBL3291346 IC50 9.0 nM
N#Cc1ccc(-c2cccc(S(=O)(=O)N3CCC(C4CCCCC4)CC3)n2)cc1 CHEMBL3339168 IC50 9.0 nM
O=S(=O)(c1cccc(-c2ccccc2)n1)N1CCC(c2ccccc2)CC1 CHEMBL3339170 IC50 9.0 nM
CC(C)(CNS(=O)(=O)c1ccccc1F)C(=O)NC1C2CC3CC1CC(C(N)=O)(C3)C2 CHEMBL3609868 IC50 9.0 nM
CSc1nc(N2C[C@@H]3[C@H](C2)[C@H]3C(=O)O)ccc1C(=O)NC1C2CC3CC(C2)CC1C3 CHEMBL3656463 IC50 9.0 nM
CCCSc1nc(NC2CCC(C(=O)O)CC2)ccc1C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 CHEMBL4113901 IC50 9.0 nM
O=C(CC1(c2ccc(F)cc2)C2CC3CC(C2)CC1C3)N1CC1 CHEMBL4065347 IC50 9.0 nM
CNC(=O)c1ccc(-c2ccc(CN3C[C@H](O)C[C@]34CCN(C3CCCCC3)C4=O)c(F)c2)cn1 CHEMBL5208260 IC50 9.0 nM
CC(C)CN1CCC[C@@H]1C(=O)NC1CCCCC1 CHEMBL5206993 IC50 9.0 nM
CNC(=O)c1ccc(N2CCN(c3cccc(C(=O)NC4C5CC6CC4CC(O)(C6)C5)n3)[C@H](C)C2)cc1 CHEMBL4780484 IC50 9.2 nM
C[C@@H]1CN(c2ccc(C(C)(C)O)cc2)CCN1c1nccc(C(=O)NC2C3CC4CC2CC(O)(C4)C3)n1 CHEMBL4779099 IC50 9.2 nM
C[C@@H](c1ccc(-c2ccc[nH]c2=O)cc1)N1CC[C@](CCCO)(c2ccc(F)cc2)OC1=O CHEMBL3664652 IC50 9.28 nM
Cn1c(-c2ccccc2OC(F)F)nnc1C12CCC(c3nc(-c4ccc(F)cc4)no3)(CC1)CC2 CHEMBL200816 IC50 9.3 nM
Cn1c(-c2ccc(C(F)(F)F)cc2)nnc1C1(c2ccc(Cl)cc2)CCC1 CHEMBL498353 IC50 9.3 nM
NC(=O)C12CC3CC(C1)C(NC(=O)C1(NC(=O)c4ccc(F)c(F)c4)CC1)C(C3)C2 CHEMBL3953909 IC50 9.3 nM
Cn1c(-c2ccc(OC(F)F)cc2)nnc1C12CCC(c3nc(-c4ccc(F)cc4)no3)(CC1)CC2 CHEMBL271211 pIC50 9.333 nM
C=C1[C@H]2C[C@H](O)[C@H]3[C@]4(C)CCC[C@@](C)(NC(=O)Nc5ccccc5)[C@H]4CC[C@]3(C2)[C@@H]1O CHEMBL2402457 IC50 9.4 nM
Cc1cc(C(=O)Nc2ccc(-c3nnc(C4(c5ccc(Cl)cc5)CCC4)n3C)cc2)c(C)o1 CHEMBL1760686 IC50 9.5 nM
COc1ccc(S(=O)(=O)N2CCC[C@]2(C)C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)cc1OC CHEMBL2152228 IC50 9.5 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1cccc(N2CCN(Cc3ccccn3)CC2)n1 CHEMBL3394410 IC50 9.5 nM
NC(=O)C12CC3CC(C1)C(NC(=O)C1(CNS(=O)(=O)c4c(F)cc(F)cc4F)CC1)C(C3)C2 CHEMBL3918438 IC50 9.5 nM
CNC(=O)c1ccc(-c2ccc(CN3C[C@H](O)C[C@]34CCN(C3CCCCC3)C4=O)cc2F)cn1 CHEMBL5182972 IC50 9.5 nM
CN(C)C(=O)c1ccc(-c2ccc(C3(C(=O)N4CC[C@@]5(C4)OC(=O)c4ccccc45)CC3)cn2)cc1 CHEMBL5173694 IC50 9.5 nM
C[C@](O)(c1ccc(C(=O)N(C2CC2)[C@H]2CC[C@](CCC(N)=O)(c3ccccn3)CC2)cc1)C(F)(F)F CHEMBL1642599 IC50 9.6 nM
NC(=O)C12CC3CC(C1)C(NC(=O)C1(CNC(=O)c4ccc(F)c(F)c4)CC1)C(C3)C2 CHEMBL3943859 IC50 9.6 nM
CC(C)N(c1ccc(C(C)(O)C(F)(F)F)cc1)S(=O)(=O)c1cccc(Cl)c1Cl CHEMBL2035411 IC50 9.7 nM
C[C@@H]1CN(c2ccc(C#N)cc2)CCN1c1nccc(C(=O)NC2C3CC4CC2CC(O)(C4)C3)n1 CHEMBL4759090 IC50 9.7 nM
Cn1c(-c2ccccc2S(C)(=O)=O)nnc1C12CCC(c3nc(-c4ccc(F)cc4)no3)(CC1)CC2 CHEMBL198690 pIC50 9.772 nM
Cc1cn(-c2ccc(-c3nnc(C4(c5ccc(Cl)cc5)CCC4)n3C)c(Cl)c2)c(C2CC2)n1 CHEMBL522572 IC50 9.8 nM
CNc1cccc(NS(=O)(=O)c2ccc(-c3ccc(C#N)cc3)cc2)n1 CHEMBL495842 Ki 9.8 nM
CC1(C)CCN([C@H]2C3CC4CC2C[C@@](O)(C4)C3)C(=O)c2cnn(-c3cccc(Cl)c3)c21 CHEMBL2338252 IC50 9.8 nM
C[C@@H]1CN(c2ccc(S(N)(=O)=O)cc2)CCN1c1cccc(C(=O)NC2C3CC4CC2CC(O)(C4)C3)n1 CHEMBL4743768 IC50 9.8 nM
O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1sc(OCCO)nc1C1CC1 CHEMBL3127862 IC50 9.9 nM
CC(C)(NS(=O)(=O)c1cc(F)cc(F)c1)C(=O)NC1C2CC3CC1CC(C(N)=O)(C3)C2 CHEMBL3960398 IC50 9.9 nM