CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1-c1ccc(CN2CCOCC2)cc1 CHEMBL252164 Ki 0.064 nM
O=C(N[C@@H]1c2ccccc2-c2c(-c3nc4cnccc4[nH]3)cccc21)c1ccnc2[nH]ccc12 CHEMBL1917878 Kd 0.35 nM
OCCCNc1ccc2c(c1)nc(-c1ccc3c(c1)OCO3)n1ncnc21 CHEMBL3309997 Ki 1.0 nM
CC1(C)CC(=O)c2c(C(F)(F)F)nn(-c3ccc(C(N)=O)c(N[C@H]4CC[C@H](O)CC4)c3)c2C1 CHEMBL560895 Ki 1.1 nM
Nc1ncnc2c1nc(Sc1cc3c(cc1I)OCO3)n2CCCNC(=S)Nc1ccc(-c2c3ccc(=O)cc-3oc3cc(O)ccc23)c(C(=O)O)c1 CHEMBL2419342 Kd(app) 1.6 nM
COc1c(C)cnc(Cn2cnc3c(Cl)nc(N)nc32)c1C CHEMBL467399 Ki 1.7 nM
COc1cc(Cl)c(-c2nc(SCC(=O)NCCF)nc3[nH]cc(C#N)c23)cc1O CHEMBL2158577 Ki 2.0 nM
CCNC(=O)CSc1nc(-c2cc(OC)c(OC)cc2Cl)c2c(C#N)c[nH]c2n1 CHEMBL2158570 Ki 2.0 nM
CCN(CC)CCOc1cc(-c2nc(SC)nc3[nH]cc(C#N)c23)c(Cl)cc1Cl CHEMBL2158626 Ki 2.0 nM
CO[C@H]1C[C@H](C)CC2=C(NCCN(C)C)C(=O)C=C(NC(=O)/C(C)=C/C=C\[C@@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@H]1O)C2=O CHEMBL3104859 Ki 2.0 nM
C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1 CHEMBL414883 Kd 2.2 nM
CO[C@H]1/C=C\C=C(/C)C(=O)NC2=CC(=O)C(NCCCCNC(=O)Cc3ccc4c(c3)C(C)(C)C3=[N+]4CCC4OC5CCN6C(=C5C=C34)C(C)(C)c3cc(S(=O)(=O)[O-])ccc36)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(\C)[C@@H]1OC(N)=O)C2=O CHEMBL2419341 Kd(app) 2.2 nM
O=C1c2ccccc2C(=O)c2cc(Cn3cc(COCc4cn(Cc5ccc6c(c5)C(=O)c5ccccc5C6=O)nn4)nn3)ccc21 CHEMBL2413569 Kd 2.8 nM
CC(C)N(CCCn1c(Sc2cc3c(cc2I)OCO3)nc2c(N)ncnc21)C(=S)Nc1ccc(-c2c3ccc(=O)cc-3oc3cc(O)ccc23)c(C(=O)O)c1 CHEMBL1910764 Kd(app) 2.8 nM
CO[C@H]1/C=C\C=C(/C)C(=O)NC2=CC(=O)C(N)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(\C)[C@@H]1OC(N)=O)C2=O CHEMBL339231 Ki 3.0 nM
COc1cc(Cl)c(-c2nc(SCC(=O)NC(C)C)nc3[nH]cc(C#N)c23)cc1O CHEMBL2158569 Ki 3.0 nM
COc1cc(Cl)c(-c2nc(SC)nc3[nH]cc(C#N)c23)cc1OCCN1CC[C@H](F)C1 CHEMBL2158627 Ki 3.0 nM
Cc1cn(-c2cc3c(c(C4CCOCC4)c2)C(=O)NCC3)c2c1C(=O)CC(C)(C)C2 CHEMBL3235355 Ki 3.0 nM
O=C1c2ccccc2C(=O)N1CCCn1cc(COCc2cn(CCCN3C(=O)c4ccccc4C3=O)nn2)nn1 CHEMBL2413570 Kd 3.5 nM
O=C(c1ccccc1)c1ccc(Cn2cc(COCc3cn(Cc4ccc(C(=O)c5ccccc5)cc4)nn3)nn2)cc1 CHEMBL2413568 Kd 3.6 nM
Cc1cn(-c2ccc3c(C)nc(N)nc3c2)c2c1C(=O)CC(C)(C)C2 CHEMBL2011854 IC50 4.0 nM
CSc1nc(-c2cc(OCCN3CCCC3)c(Cl)cc2Cl)c2c(C#N)c[nH]c2n1 CHEMBL2158625 Ki 4.0 nM
Cc1cn(-c2cc(F)c(C(N)=O)c(N[C@H]3CCOC3)c2)c2c1C(=O)CC(C)(C)C2 CHEMBL3104858 Ki 4.0 nM
CO[C@H]1/C=C\C=C(/C)C(=O)NC2=CC(=O)C(NCCN(C)C)=C(C[C@@H](C)C[C@H](OC)[C@H](OC(=O)NN)[C@@H](C)/C=C(\C)[C@@H]1OC(N)=O)C2=O CHEMBL449164 IC50 5.0 nM
COc1cc(Cl)c(-c2nc(SCC(=O)NCCF)nc3[nH]cc(C#N)c23)cc1OC CHEMBL2158576 Ki 5.0 nM
CC(C)c1cc(-c2n[nH]c(=O)n2-c2ccc3c(ccn3C)c2)c(O)cc1O CHEMBL2103879 IC50 5.0 nM
Cc1cn(-c2cc3c(c(C4CCCC4)c2)C(=O)NCC3)c2c1C(=O)CC(C)(C)C2 CHEMBL3235353 Ki 5.0 nM
Cc1cn(-c2cc3c(c(C4CCCCC4)c2)C(=O)NCC3)c2c1C(=O)CC(C)(C)C2 CHEMBL3235354 Ki 5.0 nM
Nc1nc2c3c(F)cccc3nc(Cc3ccc4c(c3)OCO4)n2n1 CHEMBL3309990 Ki 5.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)[C@H]1CC[C@H](CNS(=O)(=O)c2ccc(F)cc2)CC1 CHEMBL1940934 IC50 5.4 nM
C=CCNC1=C2C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(\C)[C@H](OC(N)=O)[C@@H](OC)/C=C\C=C(/C)C(=O)NC(=CC1=O)C2=O CHEMBL109480 IC50 7.0 nM
CCN(CC)CCSc1nc(-c2cc(OC)c(OC)cc2Cl)c2c(C#N)c[nH]c2n1 CHEMBL2158630 Ki 7.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)[C@H]1CC[C@@H](N2CCOCC2)CC1 CHEMBL1941047 IC50 7.4 nM
CCN(CC)CCOc1cc(-c2nc(SCC(=O)NC)nc3[nH]cc(C#N)c23)c(Cl)cc1Cl CHEMBL2158563 Ki 8.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)[C@H]1CC[C@H](CNC)CC1 CHEMBL1938422 IC50 8.6 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)[C@H]1CC[C@H](CN2CCOCC2)CC1 CHEMBL1941049 IC50 8.8 nM
CN1CCN(c2cc(F)c3c(c2)nc(Cc2ccc4c(c2)OCO4)n2nc(N)nc32)CC1 CHEMBL3310151 Ki 9.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1sc(C)nc1C CHEMBL1941068 IC50 10.0 nM
Cc1cn(-c2cc3c(c(-c4ccc(F)cc4)c2)C(=O)NCC3)c2c1C(=O)CC(C)(C)C2 CHEMBL3235361 Ki 10.0 nM
CC(C)NCCCn1c(Sc2cc3c(cc2I)OCO3)nc2c(N)ncnc21 CHEMBL200102 EC50 10.2 nM
c1ccc2c(Cn3cc(COCc4cn(Cc5cccc6ccccc56)nn4)nn3)cccc2c1 CHEMBL2413571 Kd 10.3 nM
C#CCCCn1c(Sc2cc3c(cc2I)OCO3)nc2c(N)ncnc21 CHEMBL372962 EC50 10.8 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)[C@@H]1CC[C@H](CN2CCOCC2)C1 CHEMBL1940949 IC50 12.0 nM
COc1cc(Cl)c(-c2nc(SC)nc3[nH]cc(C#N)c23)cc1OCCN1CCC(F)(F)C1 CHEMBL2158628 Ki 12.0 nM
CN1CCc2c3c(n(-c4ccc(C(N)=O)c(NC5CCCC5)c4)c2C1)CC(C)(C)CC3=O CHEMBL3235335 Ki 12.0 nM
Nc1nc2c3ccc(NCCO)cc3nc(Cc3ccc4c(c3)OCO4)n2n1 CHEMBL3309998 Ki 12.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)[C@@H]1CC[C@H](CO)C1 CHEMBL1940944 IC50 12.6 nM
COc1ccc(I)c(Sc2nc3c(N)ncnc3n2CCCNC(C)(C)C)c1 CHEMBL199532 IC50 14.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)C1CC(O)C1 CHEMBL1940943 IC50 14.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)[C@H]1CC[C@@H](CO)CC1 CHEMBL1940947 IC50 15.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1ccc2ncoc2c1 CHEMBL1941076 IC50 15.0 nM
Cc1cn(-c2cc3c(c(-c4ccccc4)c2)C(=O)NCC3)c2c1C(=O)CC(C)(C)C2 CHEMBL3235360 Ki 15.0 nM
CO[C@H]1C[C@H](C)Cc2cc(O)cc(c2)NC(=O)/C=C/CC[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@H]1O CHEMBL267159 Kd 16.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1cc(C(C)=O)on1 CHEMBL1941062 IC50 19.0 nM
CN1CCc2c3c(n(-c4ccc(C(N)=O)c(NCC5CC5)c4)c2C1)CC(C)(C)CC3=O CHEMBL3235336 Ki 19.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)[C@H]1CC[C@@H](CN2CCOCC2)CC1 CHEMBL1941048 IC50 19.6 nM
COc1c(C)ncc(Cn2cnc3c(Cl)nc(N)nc32)c1C CHEMBL468781 IC50 20.0 nM
COC1=C2C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(\C)[C@H](OC(N)=O)[C@@H](OC)/C=C\C=C(/C)C(=O)NC(=CC1=O)C2=O CHEMBL278315 IC50 20.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1cc(CC)on1 CHEMBL1941061 IC50 20.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1ccc2ccsc2c1 CHEMBL1941075 IC50 20.0 nM
Cc1cn(-c2cc3c(c(-c4cccc(F)c4)c2)C(=O)NCC3)c2c1C(=O)CC(C)(C)C2 CHEMBL3235362 Ki 20.0 nM
CCCNc1cc(-n2c3c(c4c2CC(C)(C)CC4=O)CCN(C)C3)ccc1C(N)=O CHEMBL3235339 Ki 21.0 nM
CCc1cc(C(N)=O)ccc1-n1nc(C(C)C)c2c(-n3cnc(-c4cnn(C)c4)c3)ccnc21 CHEMBL3661115 Ki 21.3 nM
CCc1cc(C(N)=O)ccc1-n1nc(C(C)C)c2c(-n3cnc(-c4ccnn4C)c3)ccnc21 CHEMBL5218680 Ki 21.3 nM
CC(C)NCCCn1c(Cc2cc3c(cc2I)OCO3)nc2c(N)nc(F)nc21 CHEMBL200001 EC50 22.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1ccc(N2CCCC2)cc1 CHEMBL1941059 IC50 22.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1ccc(Br)o1 CHEMBL1941064 IC50 22.0 nM
CN1CCc2c3c(n(-c4ccc(C(N)=O)c(NCC5(C)COC5)c4)c2C1)CC(C)(C)CC3=O CHEMBL3235342 Ki 22.0 nM
CN1CCc2c3c(n(-c4ccc(C(N)=O)c(NCC(C)(C)C)c4)c2C1)CC(C)(C)CC3=O CHEMBL3235344 Ki 22.0 nM
C#CCCCn1c(Cc2cc3c(cc2I)OCO3)nc2c(N)nc(F)nc21 CHEMBL377482 EC50 22.3 nM
CO[C@H]1/C=C\C=C(/C)C(=O)NC2=CC(=O)C(NCCN(C)C)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(\C)[C@@H]1OC(N)=O)C2=O CHEMBL383824 IC50 24.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)[C@H]1CC[C@@H](OC)CC1 CHEMBL1940930 IC50 24.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)C1CCN(C)CC1 CHEMBL1940940 IC50 24.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1ccc(N2CCN(C)CC2)cc1 CHEMBL1941056 IC50 24.0 nM
CCNC(=O)c1cc(C(=O)Nc2c(C(=O)NCC)noc2-c2cc(C(C)C)c(O)cc2O)on1 CHEMBL1941060 IC50 24.0 nM
CCNC(=O)c1n[nH]c(-c2cc(Cl)c(O)cc2O)c1-c1ccc(OC)cc1 CHEMBL365617 IC50 25.0 nM
CN1CCc2c3c(n(-c4ccc(C(N)=O)c(NC5CCSCC5)c4)c2C1)CC(C)(C)CC3=O CHEMBL3235338 Ki 25.0 nM
CC(C)Nc1cc(-n2c3c(c4c2CC(C)(C)CC4=O)CCN(C)C3)ccc1C(N)=O CHEMBL3235343 Ki 25.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1ccc(OC)cc1 CHEMBL1941052 IC50 26.0 nM
Cc1cn(-c2cc3c(c(CC(C)C)c2)C(=O)NCC3)c2c1C(=O)CC(C)(C)C2 CHEMBL3235352 Ki 26.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1sc(-c2ccncc2)nc1C CHEMBL1941066 IC50 27.0 nM
CC(C)Cc1cc(-n2c3c(c4c2CC(C)(C)CC4=O)CCN(C)C3)cc2c1C(=O)NCC2 CHEMBL3235350 IC50 27.0 nM
CC(C)c1cc(-c2nn(COC(=O)C(N)Cc3ccccc3)c(=O)n2-c2ccc3c(ccn3C)c2)c(O)cc1O CHEMBL3686101 IC50 27.0 nM
CCOP(=O)(CCn1c(Sc2nc3cncc(Br)c3s2)nc2c(N)ncnc21)OCC CHEMBL212133 IC50 28.0 nM
CCNC(=O)c1noc(-c2cc(Cl)c(O)cc2O)c1-c1ccc(OC)cc1 CHEMBL252124 IC50 28.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)[C@H]1CC[C@H](N)CC1 CHEMBL1940932 IC50 28.0 nM
CCNC(=O)c1cc2c(-c3cc(OCC(N)=O)c(Cl)cc3Cl)nc(N)nc2s1 CHEMBL555136 IC50 29.0 nM
CN1CCc2c3c(n(-c4ccc(C(N)=O)c(NCC(F)F)c4)c2C1)CC(C)(C)CC3=O CHEMBL3235341 Ki 29.0 nM
CC(C)c1cc(-c2nn(COC(=O)C(N)C(C)C)c(=O)n2-c2ccc3c(ccn3C)c2)c(O)cc1O CHEMBL3686100 IC50 29.0 nM
C#CCCCn1c(Sc2cc3c(cc2Br)OCO3)nc2c(N)ncnc21 CHEMBL365159 EC50 30.0 nM
CCOP(=O)(CCn1c(Sc2nc3cccc(Cl)c3s2)nc2c(N)ncnc21)OCC CHEMBL377371 IC50 30.0 nM
CCOP(=O)(CCn1c(Sc2nc3cncc(Cl)c3s2)nc2c(N)ncnc21)OCC CHEMBL212850 IC50 30.0 nM
Oc1cc(O)c(-c2noc3ccc(NCCN4CCOCC4)cc23)cc1Cl CHEMBL404630 IC50 30.0 nM
COc1ccc(I)c(Sc2nc3c(N)ncnc3n2CCNCC(C)(C)C)c1 CHEMBL381115 Activity 30.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)C1CCC(C(C)(C)C)CC1 CHEMBL1940931 IC50 30.0 nM
CC(C)Nc1cc(-n2c3c(c4c2CC(C)(C)CC4=O)CCN(C)C3)cc2c1C(=O)NCC2 CHEMBL3235345 Ki 30.0 nM
CC(C)c1cc(C(=O)N2Cc3ccc(CN4CCN(C)CC4)cc3C2)c(O)cc1O CHEMBL1214827 IC50 30.0 nM
CN(C)CCNc1ccc2c(c1)nc(Cc1ccc3c(c1)OCO3)n1nc(N)nc21 CHEMBL3310000 Ki 30.0 nM
COCCN(C)c1ccc(-n2c(O)nnc2-c2cc(C(C)C)c(O)cc2O)cn1 CHEMBL3686107 IC50 30.0 nM
C#CCCCn1c(Cc2cc3c(cc2Br)OCO3)nc2c(N)nc(F)nc21 CHEMBL199283 EC50 30.5 nM
CN1CCc2c3c(n(-c4cc(F)c(C(N)=O)c(N[C@H]5CCOC5)c4)c2C1)CC(C)(C)CC3=O CHEMBL3235333 Ki 31.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1ccc(N2CCNCC2)cc1 CHEMBL1941057 IC50 32.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1ccc(-n2cccc2)cc1 CHEMBL1941058 IC50 32.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1ccc2cc[nH]c2c1 CHEMBL1941073 IC50 33.0 nM
CCCC1Cc2cc(-n3nc(C)c4c3CC(C)(C)CC4=O)cc(N[C@H]3CC[C@H](O)CC3)c2C(=O)N1 CHEMBL4740377 IC50 33.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1ccc(OC)c(F)c1 CHEMBL1941053 IC50 34.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1ccc(N(C)C)cc1 CHEMBL1941054 IC50 34.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1ccc2ccn(C)c2c1 CHEMBL1941074 IC50 34.0 nM
Nc1nc2c3ccc(C(=O)NCCCO)cc3nc(Cc3ccc4c(c3)OCO4)n2n1 CHEMBL3309269 Ki 34.0 nM
CN1CCc2c3c(n(-c4ccc(C(N)=O)c(N[C@H]5CCOC5)c4)c2C1)CC(C)(C)CC3=O CHEMBL3235334 Ki 35.0 nM
Nc1nc2c3ccccc3nc(Cc3ccc4c(c3)OCO4)n2n1 CHEMBL3309985 Ki 35.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CC1CC1 CHEMBL3600499 IC50 35.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1cccc2cccnc12 CHEMBL1941069 IC50 36.0 nM
CCNC(=O)c1noc(-c2cc(Cl)c(O)cc2O)c1NC(C)=O CHEMBL1940918 IC50 37.0 nM
CN(C)c1cc2c(cc1Sc1nc3c(N)nccc3n1CCNCC(C)(C)C)OCO2 CHEMBL2419346 IC50 38.0 nM
CC(C)c1cc(-c2nn(COC(=O)C(NC(=O)OC(C)(C)C)C(C)C)c(=O)n2-c2ccc3c(ccn3C)c2)c(O)cc1O CHEMBL3686102 IC50 38.0 nM
CC(C)NCCCn1c(Sc2cc3c(cc2Br)OCO3)nc2c(N)ncnc21 CHEMBL383189 EC50 38.8 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)[C@@H]1CC[C@H](C(=O)O)C1 CHEMBL1940942 IC50 39.0 nM
Cc1cn(-c2cc3c(c(C4CCC4)c2)C(=O)NCC3)c2c1C(=O)CC(C)(C)C2 CHEMBL3235356 Ki 39.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)[C@H]1CC[C@H](CN)CC1 CHEMBL1940933 IC50 40.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1nc(C)c(-c2ccc(F)cc2)s1 CHEMBL1941067 IC50 40.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1cc(CN2CCOCC2)on1 CHEMBL1941079 IC50 40.0 nM
CC1(C)CC(=O)c2c3c(n(-c4ccc(C(N)=O)c(N[C@H]5CCOC5)c4)c2C1)CCCC3 CHEMBL3235351 Ki 40.0 nM
COc1ccc(-c2cc(-n3cc(C)c4c3CC(C)(C)CC4=O)cc3c2C(=O)NCC3)cc1 CHEMBL3235363 Ki 40.0 nM
CC(=O)n1ccc2cc(-n3c(O)nnc3-c3cc(C(C)C)c(O)cc3O)ccc21 CHEMBL3686097 IC50 40.0 nM
CCCc1cc2cc(-n3nc(C)c4c3CC(C)(C)CC4=O)cc(N[C@H]3CC[C@H](O)CC3)c2c(=O)[nH]1 CHEMBL4796520 IC50 40.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)C(C)(C)C CHEMBL1940926 IC50 41.0 nM
CN1CCN(c2ccc3c(c2)nc(Cc2ccc4c(c2)OCO4)n2nc(N)nc32)CC1 CHEMBL3310002 Ki 45.0 nM
CC(C)c1cc(-c2nn(C(=O)C(N)Cc3ccccc3)c(=O)n2-c2ccc3c(ccn3C)c2)c(OC(=O)C(N)Cc2ccccc2)cc1OC(=O)C(N)Cc1ccccc1 CHEMBL3686105 IC50 46.0 nM
CCN(CC)CCOc1cc(-c2nc(N)nc3sc(C(=O)NCC(F)(F)F)cc23)c(Cl)cc1Cl CHEMBL560099 IC50 47.0 nM
CC(C)c1cc(-c2nnc(O)n2-c2ccc(N(C)C)nc2)c(O)cc1O CHEMBL3686112 IC50 47.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1oc2ccc(OC)cc2c1C CHEMBL1941071 IC50 48.0 nM
CN1CCc2c3c(n(-c4ccc(C(N)=O)c(NC5CC5)c4)c2C1)CC(C)(C)CC3=O CHEMBL3235340 Ki 48.0 nM
CC(O)(C#CCc1ccccc1)c1cc(C(=O)N2Cc3ccccc3C2)ccc1O CHEMBL5276395 IC50 48.0 nM
CC(C)c1cc(-c2nnc(O)n2-c2ccc(N3CCOCC3)nc2)c(O)cc1O CHEMBL3686120 IC50 49.0 nM
Cc1nn(-c2cc(N[C@H]3CC[C@H](O)CC3)c3c(=O)[nH]c(C(C)C)cc3c2)c2c1C(=O)CC(C)(C)C2 CHEMBL4756421 IC50 51.0 nM
C#CCCCn1c(Cc2cc3c(cc2Cl)OCO3)nc2c(N)nc(F)nc21 CHEMBL201683 EC50 51.2 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(C)=O CHEMBL1940925 IC50 55.0 nM
c1ccc2cc(Cn3cc(CN(Cc4cn(Cc5ccc6ccccc6c5)nn4)Cc4cn(Cc5ccc6ccccc6c5)nn4)nn3)ccc2c1 CHEMBL2413565 Kd 55.0 nM
CCNC(=O)c1cc2c(-c3cc(OCCN(CC)CC)c(Cl)cc3Cl)nc(N)nc2s1 CHEMBL549749 IC50 56.0 nM
CCCCc1cc(-n2cc(C)c3c2CC(C)(C)CC3=O)cc2c1C(=O)NCC2 CHEMBL3235357 Ki 56.0 nM
Nc1nc2c3ccc(C(=O)NCCO)cc3nc(Cc3ccc4c(c3)OCO4)n2n1 CHEMBL3310004 Ki 56.0 nM
CC(N)C(=O)Oc1cc(OC(=O)C(C)N)c(C(C)C)cc1-c1nn(C(=O)C(C)N)c(=O)n1-c1ccc2c(ccn2C)c1 CHEMBL3686104 IC50 56.0 nM
CCNC(=O)c1cc2c(-c3cc(OCCN4CCCC4)c(Cl)cc3Cl)nc(N)nc2s1 CHEMBL563327 IC50 58.0 nM
CCNC(=O)c1cc2c(-c3cc(OCCN4CCC(F)(F)CC4)c(Cl)cc3Cl)nc(N)nc2s1 CHEMBL550023 IC50 58.0 nM
CC(C)c1cc(-c2nnc(SSc3nnc(-c4cc(C(C)C)c(O)cc4O)n3-c3ccc(N(C)C)cc3)n2-c2ccc(N(C)C)cc2)c(O)cc1O CHEMBL3686096 IC50 58.0 nM
CN(Cc1ccc(CNS(C)(=O)=O)cc1)C(=O)c1cc2c(Cc3cccc(Cl)c3)n[nH]c2cc1O CHEMBL2042883 IC50 60.0 nM
COCCNc1cc(-n2c3c(c4c2CC(C)(C)CC4=O)CCN(C)C3)ccc1C(N)=O CHEMBL3235337 Ki 60.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1cc2ccccc2n1C CHEMBL1941072 IC50 62.0 nM
CCN(CC)CCOc1nc(-c2cc(OC)c(Cl)cc2Cl)c2c(C#N)c[nH]c2n1 CHEMBL2158008 Ki 62.0 nM
CCN(CC)CCOc1cc(-c2nc(N)nc3sc(C(=O)NC4CC4)cc23)c(Cl)cc1Cl CHEMBL561428 IC50 64.0 nM
COCCNc1ccc2c(c1)nc(Cc1ccc3c(c1)OCO3)n1nc(N)nc21 CHEMBL3310003 Ki 64.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CC(C)(C)NC(=O)N(C)C CHEMBL3600790 IC50 68.0 nM
CCc1cc2cc(-n3nc(C)c4c3CC(C)(C)CC4=O)cc(N[C@H]3CC[C@H](O)CC3)c2c(=O)[nH]1 CHEMBL4740273 IC50 68.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1ccc(CN2CCOCC2)cc1 CHEMBL1941055 IC50 71.0 nM
c1ccc(-c2ccc(Cn3cc(CN(Cc4cn(Cc5ccc(-c6ccccc6)cc5)nn4)Cc4cn(Cc5ccc(-c6ccccc6)cc5)nn4)nn3)cc2)cc1 CHEMBL2413566 Kd 72.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CC(C)(C)NC(=O)c1ccc(F)nc1 CHEMBL3600800 IC50 73.0 nM
CCNC(=O)c1noc(-c2cc(Cl)c(O)cc2O)c1NC(=O)c1sccc1C CHEMBL1940917 IC50 74.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CC(C)(C)NC(C)=O CHEMBL3600513 IC50 76.0 nM
Nc1nc2c3c(F)cc(F)cc3nc(Cc3ccc4c(c3)OCO4)n2n1 CHEMBL3309991 Ki 79.0 nM
CC(C)c1cc(-c2nn(C(=O)CN)c(=O)n2-c2ccc3c(ccn3C)c2)c(OC(=O)CN)cc1OC(=O)CN CHEMBL3686103 IC50 79.0 nM
C[C@@H]1C/C=C/CC/C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1 CHEMBL526127 IC50 80.0 nM
CCNC(=O)c1cc2c(-c3cc(OCCCN(C)C)c(Cl)cc3Cl)nc(N)nc2s1 CHEMBL557689 IC50 80.0 nM
CCNC(=O)c1cc2c(-c3cc(OCC#N)c(Cl)cc3Cl)nc(N)nc2s1 CHEMBL561359 IC50 80.0 nM
Nc1ccc2c(c1)nc(Cc1ccc3c(c1)OCO3)n1nc(N)nc21 CHEMBL3309995 Ki 81.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CCN1CCOCC1 CHEMBL3600500 IC50 83.0 nM
CCNC(=O)c1cc2c(-c3cc(OCCNCCOC)c(Cl)cc3Cl)nc(N)nc2s1 CHEMBL561560 IC50 84.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1sccc1C CHEMBL1941063 IC50 84.0 nM
c1ccc2cc(Cn3cc(CCCCc4cn(Cc5ccc6ccccc6c5)nn4)nn3)ccc2c1 CHEMBL2413587 Kd 84.0 nM
Nc1nc2c3ccc(NCCN4CCCC4)cc3nc(Cc3ccc4c(c3)OCO4)n2n1 CHEMBL3310001 Ki 84.0 nM
CCNC(=O)c1noc(-c2cc(Cl)c(O)cc2O)c1NC(=O)C(C)(C)C CHEMBL1940919 IC50 85.0 nM
CC(C)c1cc(-c2nnc(O)n2-c2ccc(N(C)S(C)(=O)=O)cc2)c(O)cc1O CHEMBL3686119 IC50 85.0 nM
CCNC(=O)c1cc2c(-c3cc(ONC4CCCCC4)c(Cl)cc3Cl)nc(N)nc2s1 CHEMBL560298 IC50 87.0 nM
NCCNc1ccc2c(c1)nc(Cc1ccc3c(c1)OCO3)n1nc(N)nc21 CHEMBL3309999 Ki 87.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CN1CCC(NC(=O)c2ccc(C(F)(F)F)nc2)CC1 CHEMBL3600505 IC50 87.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CCN1CCS(=O)(=O)CC1 CHEMBL3600503 IC50 87.0 nM
Nc1nc2c3ccc(S(N)(=O)=O)cc3nc(Cc3ccc4c(c3)OCO4)n2n1 CHEMBL3309989 Ki 88.0 nM
O=C1c2ccccc2C(=O)N1CCCn1cc(CN(Cc2cn(CCCN3C(=O)c4ccccc4C3=O)nn2)Cc2cn(CCCN3C(=O)c4ccccc4C3=O)nn2)nn1 CHEMBL2413581 Kd 89.0 nM
C[C@H]1CCCC(=O)CCCCCc2cc(O)cc(O)c2C(=O)O1 CHEMBL491499 IC50 90.0 nM
C[C@H]1C[C@H]2O[C@@H]2CC/C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1 CHEMBL512064 IC50 90.0 nM
CCCc1cc2cc(-n3nc(C)c4c3CC(C)(C)CC4=O)cc(N3CCC(O)CC3)c2c(=O)[nH]1 CHEMBL4787078 IC50 91.0 nM
Cc1ccc(-n2c(O)nnc2-c2cc(C(C)C)c(O)cc2O)cc1S(=O)(=O)N(C)C CHEMBL3686115 IC50 93.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CC1CCCC1 CHEMBL3600498 IC50 99.0 nM
Cc1ncc2c(n1)CCN(C(=O)c1cc(Cl)c(O)cc1O)C2 CHEMBL3235858 IC50 100.0 nM
COCCC(=O)n1ccc2cc(-n3c(O)nnc3-c3cc(C(C)C)c(O)cc3O)ccc21 CHEMBL3686099 IC50 100.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CC(C)(C)NS(C)(=O)=O CHEMBL3600511 IC50 101.0 nM
Cc1cc2cc(-n3nc(C)c4c3CC(C)(C)CC4=O)cc(N[C@H]3CC[C@H](O)CC3)c2c(=O)[nH]1 CHEMBL4763549 IC50 101.0 nM
CCNC(=O)c1cc2c(-c3cc(OCCN4CCN(C)CC4)c(Cl)cc3Cl)nc(N)nc2s1 CHEMBL554735 IC50 102.0 nM
O=C1c2ccccc2C(=O)c2cc(Cn3cc(CN(Cc4cn(Cc5ccc6c(c5)C(=O)c5ccccc5C6=O)nn4)Cc4cn(Cc5ccc6c(c5)C(=O)c5ccccc5C6=O)nn4)nn3)ccc21 CHEMBL2413580 Kd 107.0 nM
COC(CN(C)c1ccc(-n2c(O)nnc2-c2cc(C(C)C)c(O)cc2O)cn1)OC CHEMBL3686108 IC50 107.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CC(C)(C)NC(=O)C1CC1 CHEMBL3600514 IC50 108.0 nM
Nc1ncnc2c1nc(Sc1nc3cccc(Cl)c3s1)n2CCNC1CC1 CHEMBL215947 IC50 110.0 nM
CC(C)(C)CNCCn1c(Sc2nc3cccc(Cl)c3s2)nc2c(N)ncnc21 CHEMBL215657 IC50 110.0 nM
CC(C)c1cc(-c2nnc(O)n2-c2ccc3c(ccn3C(=O)CCNC(=O)OC(C)(C)C)c2)c(O)cc1O CHEMBL3686098 IC50 110.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CC(C)(C)NC(=O)c1ccco1 CHEMBL3600792 IC50 111.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CCN1CCSCC1 CHEMBL3600504 IC50 114.0 nM
CC(C)c1cc(-c2nnc(O)n2-c2ccc(OCCN3CCOCC3)nc2)c(O)cc1O CHEMBL3686121 IC50 114.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CC(C)(C)NC(=O)C1CCCC1 CHEMBL3600387 IC50 116.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)CCN1CCN(C)CC1 CHEMBL1941051 IC50 120.0 nM
Cc1cn(-c2cc3c(c(Cc4ccccc4)c2)C(=O)NCC3)c2c1C(=O)CC(C)(C)C2 CHEMBL3235359 Ki 120.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CC(C)(C)NC(=O)c1cnc2ccccc2c1 CHEMBL3600797 IC50 120.0 nM
CCCc1cc2cc(-n3nc(C)c4c3CC(C)(C)CC4=O)cc(N3CCOCC3)c2c(=O)[nH]1 CHEMBL4791941 IC50 121.0 nM
CC1(C)CC(=O)c2ccn(-c3cc(F)c(C(N)=O)c(N[C@H]4CCOC4)c3)c2C1 CHEMBL3104860 Ki 125.0 nM
Nc1nc2c3ccc(O)cc3nc(Cc3ccc4c(c3)OCO4)n2n1 CHEMBL3309993 Ki 126.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CC(C)(C)NC(=O)N1CCOCC1 CHEMBL3600791 IC50 126.0 nM
CCNC(=O)c1cc2c(-c3cc(OCCN(C)C)c(Cl)cc3Cl)nc(N)nc2s1 CHEMBL549817 IC50 127.0 nM
CCNC(=O)c1noc(-c2cc(Cl)c(O)cc2O)c1NC(=O)c1cc(OC)c(OC)c(OC)c1 CHEMBL1940916 IC50 130.0 nM
CC(C)NC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#Cc1ccccc1 CHEMBL3600494 IC50 133.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CCN1C[C@@H](C)O[C@@H](C)C1 CHEMBL3600502 IC50 135.0 nM
Cc1cn(-c2cc3c(c(C(C)(C)C)c2)C(=O)NCC3)c2c1C(=O)CC(C)(C)C2 CHEMBL3235358 Ki 140.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CC1CCCCC1 CHEMBL3600497 IC50 141.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CCN1CCC(=NOC)CC1 CHEMBL3600501 IC50 142.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CC(C)(C)NC(=O)c1ccc(C)nc1 CHEMBL3600796 IC50 143.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#Cc1ccccc1 CHEMBL3600496 IC50 144.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CCNC(=O)c1ccc(C(F)(F)F)nc1 CHEMBL3600508 IC50 146.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CCNC(=O)c1ccc(C(F)(F)F)cc1 CHEMBL3600507 IC50 149.0 nM
Cc1cccc(Cc2n[nH]c3cc(O)c(C(=O)N(C)Cc4ccc(CNS(C)(=O)=O)cc4)cc23)c1 CHEMBL2042769 IC50 150.0 nM
O=C(c1ccccc1)c1ccc(Cn2cc(CN(Cc3cn(Cc4ccc(C(=O)c5ccccc5)cc4)nn3)Cc3cn(Cc4ccc(C(=O)c5ccccc5)cc4)nn3)nn2)cc1 CHEMBL2413579 Kd 151.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CC(C)(C)NC(=O)c1cccnc1 CHEMBL3600795 IC50 151.0 nM
CCNC(=O)c1noc(-c2cc(Cl)c(O)cc2O)c1NC(=O)c1ccc(Br)cc1 CHEMBL1940913 IC50 153.0 nM
CCCCc1cc2cc(-n3nc(C)c4c3CC(C)(C)CC4=O)cc(N[C@H]3CC[C@H](O)CC3)c2c(=O)[nH]1 CHEMBL4761498 IC50 156.0 nM
COCc1cc2cc(-n3nc(C)c4c3CC(C)(C)CC4=O)cc(N[C@H]3CC[C@H](O)CC3)c2c(=O)[nH]1 CHEMBL4791530 IC50 159.0 nM
C[C@@H]1C[C@H]2C[C@@H]2/C=C\C=C\C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1 CHEMBL468439 ED50 160.0 nM
COc1ccc(C(=O)Nc2c(C(=O)NCC(F)(F)F)noc2-c2cc(Cl)c(O)cc2O)cc1 CHEMBL1940922 IC50 160.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CN1CCN(C(=O)c2ccc(C(F)(F)F)nc2)CC1 CHEMBL3600506 IC50 160.0 nM
CCNC(=O)c1noc(-c2cc(Cl)c(O)cc2O)c1NC(=O)c1ccc(OC)c(OC)c1 CHEMBL1940915 IC50 163.0 nM
C=CC(=O)Nc1c(C(=O)NCC)noc1-c1cc(Cl)c(O)cc1O CHEMBL1940920 IC50 167.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CCNC(=O)c1cnc2ccccc2c1 CHEMBL3600510 IC50 167.0 nM
CCNC(=O)c1noc(-c2cc(Cl)c(O)cc2O)c1NC(=O)CCN1CCOCC1 CHEMBL1940924 IC50 168.0 nM
Cc1cccc(Cc2n[nH]c3cc(O)c(C(=O)N(C)Cc4ccc(Cl)c(F)c4)cc23)c1 CHEMBL2042764 IC50 170.0 nM
COc1cc(Cl)c(-c2nc(SC(C)C)nc3[nH]cc(C#N)c23)cc1OCCN1CCC(F)(F)C1 CHEMBL2158565 Ki 172.0 nM
CCNC(=O)c1cc2c(-c3cc(OC4CCN(CC)C4)c(Cl)cc3Cl)nc(N)nc2s1 CHEMBL560835 IC50 176.0 nM
Nc1nc2c3c(NCCO)cc(F)cc3nc(Cc3ccc4c(c3)OCO4)n2n1 CHEMBL3310152 Ki 179.0 nM
CCCCn1c(Sc2nc3cccc(Cl)c3s2)nc2c(N)ncnc21 CHEMBL213262 IC50 180.0 nM
COCCN(C)c1ccc(-n2c(O)nnc2-c2cc(C(C)C)c(O)cc2O)c[n+]1[O-] CHEMBL3686109 IC50 180.0 nM
CC(C)c1cc(C(=O)N2Cc3ccccc3C2)c(O)c2cnoc12 CHEMBL4474770 Kd 180.0 nM
CC(C)(C)c1ccc(Cn2cc(-c3cc(O)c(O)c(O)c3)nn2)cc1 CHEMBL4741221 IC50 180.0 nM
CC(C)NC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CCN1CCOCC1 CHEMBL3600435 IC50 182.0 nM
CCNC(=O)c1noc(-c2cc(Cl)c(O)cc2O)c1NC(=O)c1ccc(OC)cc1 CHEMBL1940914 IC50 184.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)C1CCCCC1 CHEMBL1940927 IC50 190.0 nM
c1ccc2c(Cn3cc(CCCCc4cn(Cc5cccc6ccccc56)nn4)nn3)cccc2c1 CHEMBL2413586 Kd 191.0 nM
CSc1nc(-c2ccc(C)cc2C)c2c(C#N)c[nH]c2n1 CHEMBL2158581 Ki 195.0 nM
Cc1cccc(Cc2n[nH]c3cc(O)c(C(=O)N(C)Cc4cccc(NS(C)(=O)=O)c4)cc23)c1 CHEMBL2042767 IC50 200.0 nM
c1ccc2c(Cn3cc(CN(Cc4cn(Cc5cccc6ccccc56)nn4)Cc4cn(Cc5cccc6ccccc56)nn4)nn3)cccc2c1 CHEMBL2413582 Kd 201.0 nM
CSc1nc(-c2ccc(C#N)cc2)c2c(C#N)c[nH]c2n1 CHEMBL2158583 Ki 204.0 nM
CC(C)c1cc(-c2nnc(O)n2-c2ccc(N(C)C)c(S(N)(=O)=O)c2)c(O)cc1O CHEMBL3686116 IC50 207.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)CCN1CCOCC1 CHEMBL1941050 IC50 214.0 nM
CC(C)c1cc(-c2nnc(O)n2-c2ccc(N(C)CCN(C)C)nc2)c(O)cc1O CHEMBL3686111 IC50 220.0 nM
CC(C)c1cc(-c2nnc(O)n2-c2ccc(N3CCN(C)CC3)nc2)c(O)cc1O CHEMBL3686113 IC50 220.0 nM
CCNC(=O)c1cc2c(-c3ccc(Cl)cc3Cl)nc(N)nc2s1 CHEMBL563168 IC50 230.0 nM
CCNC(=O)c1noc(-c2cc(Cl)c(O)cc2O)c1NCc1sccc1C CHEMBL1941080 IC50 230.0 nM
CN(Cc1ccccc1)C(=O)c1cc2c(CCc3ccccc3)n[nH]c2cc1O CHEMBL2042895 IC50 230.0 nM
Cc1nn(-c2cc(N[C@H]3CC[C@H](O)CC3)c3c(=O)[nH]c(CO)cc3c2)c2c1C(=O)CC(C)(C)C2 CHEMBL4763239 IC50 233.0 nM
c1ccc(-c2ccc(Cn3cc(COCc4cn(Cc5ccc(-c6ccccc6)cc5)nn4)nn3)cc2)cc1 CHEMBL2413573 Kd 237.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CC(C)(C)NS(=O)(=O)c1ccc(C)cc1 CHEMBL3600512 IC50 237.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)C1CCC(C(F)(F)F)CC1 CHEMBL1940929 IC50 240.0 nM
CCNC(=O)c1noc(-c2cc(Cl)c(O)cc2O)c1NC(=O)C12CC3CC(CC(C3)C1)C2 CHEMBL1940921 IC50 250.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1cc(-c2ccccc2)on1 CHEMBL1941065 IC50 250.0 nM
Cc1cccc(Cc2n[nH]c3cc(O)c(C(=O)N(C)Cc4ccccc4)cc23)c1 CHEMBL2042870 IC50 250.0 nM
CN1CCN(c2cc(F)cc3nc(Cc4ccc5c(c4)OCO5)n4nc(N)nc4c23)CC1 CHEMBL3310156 Ki 257.0 nM
CC(=O)c1ccc(NC(=O)c2cn[nH]c2-c2cc(Cl)c(O)cc2O)cc1 CHEMBL200469 IC50 258.0 nM
CCCCC[C@H]1CC[C@H](C(=O)Nc2c(C(=O)NCC)noc2-c2cc(C(C)C)c(O)cc2O)CC1 CHEMBL1940928 IC50 260.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1NC(=O)c1oc2ccccc2c1C CHEMBL1941070 IC50 260.0 nM
Cc1nn(-c2cc(N[C@H]3CC[C@H](O)CC3)c3c(=O)[nH]c(CC(C)C)cc3c2)c2c1C(=O)CC(C)(C)C2 CHEMBL4761885 IC50 264.0 nM
C#CCCCn1c(Sc2cc(OC)ccc2I)nc2c(N)ncnc21 CHEMBL191635 IC50 280.0 nM
CCc1cc(-c2n[nH]cc2-c2c[nH]cn2)c(O)cc1O CHEMBL360563 Kd 280.0 nM
CCNC(=O)c1cc2c(-c3ccc(C#N)cc3C)nc(N)nc2s1 CHEMBL564860 IC50 300.0 nM
Nc1ncc2c(n1)CCN(C(=O)c1cc(Cl)c(O)cc1O)C2 CHEMBL3235857 IC50 310.0 nM
CO[C@H]1[C@@H](OC)C[C@H](C)CC2=C(N)C(=O)C=C(NC(=O)/C(C)=C/C=C\[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@@H]1C)C2=O CHEMBL493230 Kd 320.0 nM
CC(O)(CCCc1ccccn1)c1cc(C(=O)N2Cc3ccccc3C2)ccc1O CHEMBL5277312 IC50 328.0 nM
CN(Cc1ccc(Cl)cc1)C(=O)c1cc2c(Cc3ccccc3)n[nH]c2cc1O CHEMBL2042857 IC50 330.0 nM
CC(C)c1cc(-c2nnc(O)n2-c2ccc(N(C)CC(=O)O)nc2)c(O)cc1O CHEMBL3686110 IC50 330.0 nM
CC(C)c1cc(-c2nnc(O)n2-c2cccc(S(=O)(=O)N3CCOCC3)c2)c(O)cc1O CHEMBL3686118 IC50 330.0 nM
Nc1nc2c3cccc(O)c3nc(Cc3ccc4c(c3)OCO4)n2n1 CHEMBL3309994 Ki 332.0 nM
CC(C)c1cc(-c2nnc(S)n2-c2cccc(S(N)(=O)=O)c2)c(O)cc1O CHEMBL3686117 IC50 336.0 nM
CCNC(=O)c1cc2c(-c3ccc(C)cc3C)nc(N)nc2s1 CHEMBL549674 IC50 340.0 nM
Cc1cccc(Cc2n[nH]c3cc(O)c(C(=O)N(C)Cc4ccc(NS(C)(=O)=O)cc4)cc23)c1 CHEMBL2042768 IC50 350.0 nM
CSc1nc(-c2ccc(F)cc2C)c2c(C#N)c[nH]c2n1 CHEMBL2158582 Ki 358.0 nM
Cc1cccc(Cc2n[nH]c3cc(O)c(C(=O)N(C)Cc4cccc(F)c4)cc23)c1 CHEMBL2042761 IC50 370.0 nM
CC(=O)Nc1nnc(-c2cc(C(C)C)c(O)cc2O)n1-c1ccc2c(ccn2C)c1 CHEMBL3686082 IC50 382.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CC(C)(C)NC(=O)C1CCCCC1 CHEMBL3600789 IC50 384.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CC(C)(C)NC(=O)c1ccc(C(F)(F)F)nc1 CHEMBL3600799 IC50 389.0 nM
CCc1ccc(CN(C)C(=O)c2cc3c(Cc4ccccc4)n[nH]c3cc2O)cc1 CHEMBL2042860 IC50 390.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CC(C)(C)NC(=O)c1ccc(OC)nc1 CHEMBL3600798 IC50 393.0 nM
CO[C@H]1/C=C\C=C(/C)C(=O)NC2=CC(=O)C(NCCN3CCC3)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(\C)[C@@H]1OC(N)=O)C2=O CHEMBL506146 Kd 400.0 nM
CO[C@H]1/C=C\C=C(/C)C(=O)NC2=CC(=O)C(NCCN3CCCC3)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(\C)[C@@H]1OC(N)=O)C2=O CHEMBL505400 Kd 400.0 nM
CN(Cc1ccccc1)C(=O)c1cc2c(Cc3cccc(Cl)c3)n[nH]c2cc1O CHEMBL2042868 IC50 400.0 nM
CCCCSc1c(-n2cc(C)c3c2CC(C)(C)CC3=O)ccc2c(N)ncnc12 CHEMBL2011850 IC50 401.0 nM
CN(Cc1cccc(NS(C)(=O)=O)c1)C(=O)c1cc2c(Cc3cccc(Cl)c3)n[nH]c2cc1O CHEMBL2042882 IC50 410.0 nM
CN1CCc2c3c(n(-c4ccc(C(N)=O)c(CCC5CC5)c4)c2C1)CC(C)(C)CC3=O CHEMBL3235349 Ki 420.0 nM
CCCc1cc2cc(-n3nc(C)c4c3CC(C)(C)CC4=O)cc(N3CCN(C)CC3)c2c(=O)[nH]1 CHEMBL4786075 IC50 426.0 nM
COCC#CC(C)(O)c1cc(C(=O)N2Cc3ccccc3C2)ccc1O CHEMBL5280465 IC50 426.0 nM
CCNC(=O)c1noc(-c2cc(Cl)c(O)cc2O)c1NCc1ccc(OC)cc1 CHEMBL1941081 IC50 430.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#CC(C)(C)NCc1ccc(C(F)(F)F)cc1 CHEMBL3600793 IC50 446.0 nM
COc1ccc(CN(C)C(=O)c2cc3c(Cc4cccc(C)c4)n[nH]c3cc2O)cc1 CHEMBL2042763 IC50 460.0 nM
NS(=O)(=O)c1ccc(CNC(=O)c2cn[nH]c2-c2cc(Cl)c(O)cc2O)cc1 CHEMBL200255 IC50 461.0 nM
CCCc1cc2cc(-n3nc(C)c4c3CC(C)(C)CC4=O)cc(N3CCN(C(=O)OC(C)(C)C)CC3)c2c(=O)[nH]1 CHEMBL4739925 IC50 463.0 nM
COc1cccc(CN(C)C(=O)c2cc3c(Cc4ccccc4)n[nH]c3cc2O)c1OC CHEMBL2042862 IC50 470.0 nM
COC1=C2C[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)/C=C(\C)[C@H](OC(N)=O)[C@@H](OC)/C=C\C=C(/C)C(=O)NC(=CC1=O)C2=O CHEMBL492811 Kd 490.0 nM
Cc1c2c(n(-c3ccc4c(N)ncnc4c3)c1C)CC(C)(C)CC2=O CHEMBL2011855 IC50 498.0 nM
Cc1cccc(Cc2n[nH]c3cc(O)c(C(=O)N(C)Cc4ccc(F)c(F)c4)cc23)c1 CHEMBL2042766 IC50 500.0 nM
CCCc1cc2cc(-n3nc(C)c4c3CC(C)(C)CC4=O)cc(NC3CCN(C)CC3)c2c(=O)[nH]1 CHEMBL4756340 IC50 513.0 nM
CC(O)(CCCc1cccnc1)c1cc(C(=O)N2Cc3ccccc3C2)ccc1O CHEMBL5286973 IC50 563.0 nM
Cc1cn(-c2ccc3c(N)ncnc3c2)c2c1C(=O)CC(C)(C)C2 CHEMBL2011843 IC50 568.0 nM
CN(Cc1cccc(F)c1)C(=O)c1cc2c(Cc3ccccc3)n[nH]c2cc1O CHEMBL2042901 IC50 570.0 nM
Cc1cccc(Cc2n[nH]c3cc(O)c(C(=O)N(C)Cc4ccc(F)cc4)cc23)c1 CHEMBL2042762 IC50 580.0 nM
COc1ccc(CN(C)C(=O)c2cc3c(Cc4cccc(C)c4)n[nH]c3cc2O)cc1OC CHEMBL2040870 IC50 580.0 nM
CN1CCc2c3c(n(-c4ccc(C(N)=O)cc4)c2C1)CC(C)(C)CC3=O CHEMBL3235330 Ki 580.0 nM
CN(Cc1ccccc1Br)C(=O)c1cc2c(Cc3cccc(Cl)c3)n[nH]c2cc1O CHEMBL2042877 IC50 590.0 nM
CN1CCc2c3c(n(-c4ccc5c(c4)CCNC5=O)c2C1)CC(C)(C)CC3=O CHEMBL3235347 Ki 590.0 nM
Oc1cc(O)c(-c2n[nH]cc2N2CCN(Cc3ccccc3)CC2)cc1Cl CHEMBL251974 IC50 600.0 nM
CN(C(=O)c1cc2c(Cc3ccccc3)n[nH]c2cc1O)c1ccco1 CHEMBL2042894 IC50 610.0 nM
CN(Cc1ccccc1Br)C(=O)c1cc2c(Cc3ccccc3)n[nH]c2cc1O CHEMBL2042898 IC50 610.0 nM
CCNC(=O)c1noc(-c2cc(Cl)c(O)cc2O)c1NC1CCCCC1 CHEMBL1941082 IC50 620.0 nM
COc1nc(-c2ccc(F)cc2C)c2c(C#N)c[nH]c2n1 CHEMBL2158622 Ki 628.0 nM
Cc1ccc(CN(C)C(=O)c2cc3c(Cc4ccccc4)n[nH]c3cc2O)cc1 CHEMBL2042859 IC50 630.0 nM
CC(C)c1cc(-c2onc(C(N)=O)c2C#CCN2CCOCC2)c(O)cc1O CHEMBL3600434 IC50 636.0 nM
CC(O)(CCCc1ccncc1)c1cc(C(=O)N2Cc3ccccc3C2)ccc1O CHEMBL5289895 IC50 639.0 nM
COc1ccc(OCCOCC(O)CN2CCN(c3ccccc3C(C)(C)C)CC2)cc1 CHEMBL3126081 IC50 640.0 nM
NCCNc1cc(F)cc2nc(Cc3ccc4c(c3)OCO4)n3nc(N)nc3c12 CHEMBL3310155 Ki 656.0 nM
CN(Cc1ccccc1)C(=O)c1cc2c(Cc3ccccc3)n[nH]c2cc1O CHEMBL2042893 IC50 660.0 nM
C#CCCCn1c(Cc2cc(OC)c(OC)c(OC)c2Cl)nc2c(N)nc(F)nc21 CHEMBL112953 IC50 660.0 nM
CSc1nc(-c2ccc(Cl)cc2C)c2nc[nH]c2n1 CHEMBL2158635 Ki 661.0 nM
Cc1cn(-c2ccc3c(N)ncnc3c2F)c2c1C(=O)CC(C)(C)C2 CHEMBL2011847 IC50 665.0 nM
CCc1cc(-c2n[nH]c(C(=O)O)c2-c2ccc3c(c2)OCO3)c(O)cc1O CHEMBL178130 Kd 680.0 nM
COc1cc(CN(C)C(=O)c2cc3c(Cc4cccc(C)c4)n[nH]c3cc2O)ccc1Cl CHEMBL2042765 IC50 680.0 nM
CC(C)c1cc(-c2nnc(Nc3ccc4ncccc4c3)n2-c2ccc3c(ccn3C)c2)c(O)cc1O CHEMBL3686076 IC50 680.0 nM
Nc1nc2c3ccc(F)cc3nc(Cc3ccc4c(c3)OCO4)n2n1 CHEMBL3309988 Ki 690.0 nM
O=S(=O)(Nc1ccc(O)c(-c2c(O)ccc3ccccc23)c1)c1cc(Cl)ccc1Cl CHEMBL371915 IC50 700.0 nM
Cc1cn(-c2ccc3cnc(N)nc3c2)c2c1C(=O)CC(C)(C)C2 CHEMBL2011853 IC50 705.0 nM
CN(Cc1cccc(F)c1)C(=O)c1cc2c(Cc3cccc(Cl)c3)n[nH]c2cc1O CHEMBL2042878 IC50 710.0 nM
CCNC(=O)c1cc2c(-c3ccc(Cl)cc3)nc(N)nc2s1 CHEMBL554503 IC50 720.0 nM
COc1ccc(CN(C)C(=O)c2cc3c(Cc4cccc(Cl)c4)n[nH]c3cc2O)cc1OC CHEMBL2042881 IC50 730.0 nM
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)N[C@H](C(=O)N[C@H]1CCCCNC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC1=O)[C@@H](C)CC CHEMBL3360777 IC50 730.0 nM
Cc1nc(N)c2ccc(-n3cc(C)c4c3CC(C)(C)CC4=O)cc2n1 CHEMBL2011845 IC50 731.0 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1C#Cc1ccc(C(C)(C)C)cc1 CHEMBL3600495 IC50 736.0 nM
CS(=O)(=O)c1ccc(CN2CCN(c3cn[nH]c3-c3cc(Cl)c(O)cc3O)CC2)cc1 CHEMBL208239 IC50 740.0 nM
Cc1ccccc1CN(C)C(=O)c1cc2c(Cc3ccccc3)n[nH]c2cc1O CHEMBL2042899 IC50 740.0 nM
CC(C)(C)c1ccccc1N1CCN(CC(O)COCCOc2ccc(Cl)cc2)CC1 CHEMBL3126076 IC50 750.0 nM
CCOc1ccc(CN(C)C(=O)c2cc3c(Cc4ccccc4)n[nH]c3cc2O)cc1 CHEMBL2042861 IC50 760.0 nM
Cc1cccc(Cc2n[nH]c3cc(O)c(C(=O)N(C)Cc4ccccc4Br)cc23)c1 CHEMBL2042760 IC50 780.0 nM
CO[C@H]1/C=C\C=C(/C)C(=O)NC2=CC(=O)C(NCCF)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(\C)[C@@H]1OC(N)=O)C2=O CHEMBL421647 Kd 800.0 nM
CO[C@H]1[C@@H](OC)C[C@H](C)CC2=C(NCCN(C)C)C(=O)C=C(NC(=O)/C(C)=C/C=C\[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@@H]1C)C2=O CHEMBL506415 Kd 800.0 nM
CO[C@H]1/C=C\C=C(/C)C(=O)NC2=CC(=O)C(NCCc3c[nH]cn3)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(\C)[C@@H]1OC(N)=O)C2=O CHEMBL501133 Kd 800.0 nM
CN(Cc1ccc(F)cc1)C(=O)c1cc2c(Cc3cccc(Cl)c3)n[nH]c2cc1O CHEMBL2042879 IC50 800.0 nM
COc1ccc(CN(C)C(=O)c2cc3c(Cc4cccc(Cl)c4)n[nH]c3cc2O)cc1 CHEMBL2042880 IC50 800.0 nM
Cc1ccc(OCCOCC(O)CN2CCN(c3ccccc3C(C)(C)C)CC2)cc1 CHEMBL3126079 IC50 870.0 nM
CCOc1ccc(-c2c(C#N)c(N)nc3sc(C(N)=O)c(N)c23)cc1 CHEMBL554496 IC50 900.0 nM
Nc1cc(C(=O)NC2c3ccccc3-c3c(-c4nc5cnccc5[nH]4)cccc32)ccn1 CHEMBL1917729 IC50 900.0 nM
Cc1ccc(-c2nc(N)nc3ccc(Cl)cc23)cc1 CHEMBL2042887 IC50 900.0 nM
CN(Cc1ccccc1F)C(=O)c1cc2c(Cc3ccccc3)n[nH]c2cc1O CHEMBL2042896 IC50 900.0 nM
CCc1ccc(OCCOCC(O)CN2CCN(c3ccccc3C(C)(C)C)CC2)cc1 CHEMBL3126058 IC50 920.0 nM
O=C(c1cc(Cl)c(O)cc1O)N1CCc2nc(N3CCN(c4ncccn4)CC3)ncc2C1 CHEMBL3235856 IC50 930.0 nM
Cc1nn(-c2cc(N[C@H]3CC[C@H](O)CC3)c3c(=O)[nH]c(C4CC4)cc3c2)c2c1C(=O)CC(C)(C)C2 CHEMBL4796556 IC50 946.0 nM
CCCc1ccc(OCCOCC(O)CN2CCN(c3ccccc3C(C)(C)C)CC2)cc1 CHEMBL3126082 IC50 950.0 nM
CC(C)(C)c1ccccc1N1CCN(CC(O)COCCOc2ccc(Br)cc2)CC1 CHEMBL3126062 IC50 970.0 nM
COc1cccc(CN(C)C(=O)c2cc3c(Cc4ccccc4)n[nH]c3cc2O)c1 CHEMBL2042905 IC50 980.0 nM
CN(Cc1ccc(Cl)c(F)c1)C(=O)c1cc2c(Cc3ccccc3)n[nH]c2cc1O CHEMBL2042864 IC50 980.0 nM
CO[C@H]1[C@@H](OC)C[C@H](C)CC2=C(NCCN3CCC3)C(=O)C=C(NC(=O)/C(C)=C/C=C\[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@@H]1C)C2=O CHEMBL448261 Kd 1000.0 nM
CO[C@H]1[C@@H](OC)C[C@H](C)CC2=C(NCCN3CCCC3)C(=O)C=C(NC(=O)/C(C)=C/C=C\[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@@H]1C)C2=O CHEMBL506191 Kd 1000.0 nM
CCCCn1c(Cc2cc(OC)c(OC)c(OC)c2)nc2c(N)ncnc21 CHEMBL113690 IC50 1000.0 nM