CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1-c1ccc(CN2CCOCC2)cc1 CHEMBL252164 Ki 4.0 nM
CO[C@H]1C[C@H](C)CC2=C(NCCN(C)C)C(=O)C=C(NC(=O)/C(C)=C/C=C\[C@@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@H]1O)C2=O CHEMBL3104859 Ki 5.0 nM
CC(C)c1cc(C(=O)N2Cc3ccc(CN4CCN(C)CC4)cc3C2)c(O)cc1O CHEMBL1214827 IC50 22.0 nM
CC(C)NCCCn1c(Sc2cc3c(cc2I)OCO3)nc2c(N)ncnc21 CHEMBL200102 IC50 26.0 nM
COC(=O)c1c(O)cc(O)c(Cl)c1CCc1nccn1Cc1ccccc1 CHEMBL3426787 IC50 32.0 nM
CC(C)c1cc(-c2n[nH]c(=O)n2-c2ccc3c(ccn3C)c2)c(O)cc1O CHEMBL2103879 IC50 37.7 nM
COC(=O)Cn1nnc(-c2cc(C(C)C)c(O)cc2O)c1-c1ccc(CN2CCCCC2)cc1 CHEMBL4647894 IC50 49.42 nM
Cc1ncc2c(n1)CN(C(=O)c1cc(C(C)C)c(O)cc1O)C2 CHEMBL4744238 IC50 50.0 nM
COC(=O)Cn1nnc(-c2cc(C(C)C)c(O)cc2O)c1-c1cccc(S(C)(=O)=O)c1 CHEMBL4647171 IC50 54.1 nM
COc1c(C)cnc(Cn2cc(C#CCC(C)(C)O)c3c(Cl)nc(N)nc32)c1C CHEMBL1230584 Ki 61.0 nM
COC(=O)Cn1nnc(-c2cc(C(C)C)c(O)cc2O)c1-c1ccc2c(c1)OCCO2 CHEMBL4635982 IC50 77.96 nM
CC(C)c1cc(-c2nnn(Cc3ccccc3)c2-c2ccc(S(C)(=O)=O)cc2)c(O)cc1O CHEMBL4641526 IC50 78.01 nM
COC(=O)Cn1nnc(-c2cc(C(C)C)c(O)cc2O)c1-c1ccc(S(C)(=O)=O)cc1 CHEMBL4639163 IC50 88.98 nM
COC(=O)c1c(O)cc(O)c(Cl)c1CCc1nccn1Cc1ccccc1OC(C)C CHEMBL3805415 Kd 90.0 nM
CCOC(=O)Cn1nnc(-c2cc(C(C)C)c(O)cc2O)c1-c1cccc(S(C)(=O)=O)c1 CHEMBL4635778 IC50 96.2 nM
CCOC(=O)Cn1nnc(-c2cc(C(C)C)c(O)cc2O)c1-c1ccc(S(C)(=O)=O)cc1 CHEMBL4648197 IC50 100.46 nM
CC(C)NCCCn1c(Sc2cc3c(cc2I)OCO3)nc2c(N)nccc21 CHEMBL3426784 IC50 101.0 nM
CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O CHEMBL464859 Ki 110.0 nM
C#CCCCn1c(Sc2ccc(Cl)cc2Cl)nc2c(N)ncnc21 CHEMBL365118 IC50 120.0 nM
CNC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O CHEMBL519809 Ki 130.0 nM
C#CCCCn1c(Sc2cc(Cl)c(Cl)cc2Cl)nc2c(N)ncnc21 CHEMBL192480 IC50 170.0 nM
COC(=O)Cn1nnc(-c2cc(C(C)C)c(O)cc2O)c1-c1ccc(OCCN(C)C)cc1 CHEMBL4648091 IC50 174.8 nM
COc1c(C)cnc(Cn2cnc3c(Cl)nc(N)nc32)c1C CHEMBL467399 Ki 176.0 nM
COC(=O)Cn1nnc(-c2cc(C(C)C)c(O)cc2O)c1-c1cccc(NS(C)(=O)=O)c1 CHEMBL4638275 IC50 190.22 nM
CCOC(=O)Cn1nnc(-c2cc(C(C)C)c(O)cc2O)c1-c1ccc2c(c1)OCCO2 CHEMBL4641450 IC50 192.09 nM
Nc1nc(Cl)c2nc(O)n(Cc3cc4c(cc3Br)OCO4)c2n1 CHEMBL4869481 IC50 194.0 nM
COCCOc1nc2c(c(N(C)C)n1)CN(C(=O)c1cc(C(C)C)c(O)cc1O)CC2 CHEMBL4779990 IC50 195.0 nM
CNc1nc(OCCOC)nc2c1CN(C(=O)c1cc(C(C)C)c(O)cc1O)CC2 CHEMBL4782374 IC50 196.0 nM
COC(=O)Cn1nnc(-c2cc(C(C)C)c(O)cc2O)c1-c1ccc(CN2CCOCC2)cc1 CHEMBL4636983 IC50 197.13 nM
COCCOc1ncc2c(n1)CCN(C(=O)c1cc(C(C)C)c(O)cc1O)C2 CHEMBL4797602 IC50 198.0 nM
CCOc1ccccc1Cn1ccnc1CCc1c(Cl)c(O)cc(O)c1C(=O)OC CHEMBL3805249 Kd 200.0 nM
CCOC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O CHEMBL5073759 Kd 200.0 nM
CCOC(=O)Cn1nnc(-c2cc(C(C)C)c(O)cc2O)c1-c1cccc(NS(C)(=O)=O)c1 CHEMBL4649532 IC50 209.28 nM
COCCOc1nc2c(c(NC3CC3)n1)CN(C(=O)c1cc(C(C)C)c(O)cc1O)CC2 CHEMBL4753741 IC50 216.0 nM
CCN(CC)CCOc1ncc2c(n1)CCN(C(=O)c1cc(C(C)C)c(O)cc1O)C2 CHEMBL4777147 IC50 217.0 nM
CC(C)NCCCn1c(Sc2cc(Cl)cc(Cl)c2)nc2c(N)ncnc21 CHEMBL3426781 IC50 220.0 nM
COCCOc1nc2c(c(OC)n1)CN(C(=O)c1cc(C(C)C)c(O)cc1O)CC2 CHEMBL4753836 IC50 232.0 nM
C#CCCCn1c(Sc2cc(Cl)cc(Br)c2)nc2c(N)ncnc21 CHEMBL3426734 IC50 240.0 nM
Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NC2CC2)[C@@H](O)[C@H]1O CHEMBL261482 Ki 240.0 nM
Cc1ncc2c(n1)CCN(C(=O)c1cc(C(C)C)c(O)cc1O)C2 CHEMBL4781723 IC50 245.0 nM
CCCOc1ccccc1Cn1ccnc1CCc1c(Cl)c(O)cc(O)c1C(=O)OC CHEMBL3805519 Kd 250.0 nM
C#CCCCn1c(Sc2cc(Cl)cc(Cl)c2)nc2c(N)ncnc21 CHEMBL192013 IC50 260.0 nM
CC(C)NCCCn1c(Sc2cc3c(cc2N(C)C)OCO3)nc2c(N)ncnc21 CHEMBL3426785 IC50 265.0 nM
C#CCCn1c(Sc2cc(Cl)cc(Cl)c2)nc2c(N)ncnc21 CHEMBL3426741 IC50 287.0 nM
C#CCCCn1c(Sc2cc(Br)cc(Br)c2)nc2c(N)ncnc21 CHEMBL3426735 IC50 290.0 nM
CC(C)c1cc(C(=O)N2CCc3nc(OCCN(C)C)ncc3C2)c(O)cc1O CHEMBL4744192 IC50 290.0 nM
Cc1ccc(Cn2c(O)nc3c(Cl)nc(N)nc32)c(F)c1 CHEMBL4863672 IC50 318.0 nM
C#CCCCn1c(C(=O)c2ccc(Cl)cc2Cl)nc2c(N)ncnc21 CHEMBL3426763 IC50 340.0 nM
C#CCCCn1c(Sc2ccccc2Cl)nc2c(N)ncnc21 CHEMBL190439 IC50 350.0 nM
COC(=O)c1c(O)cc(O)c(Cl)c1CCc1nccn1Cc1oc(C)cc1C CHEMBL3805794 Kd 350.0 nM
Cc1cn(-c2cc(F)c(C(N)=O)c(N[C@H]3CCOC3)c2)c2c1C(=O)CC(C)(C)C2 CHEMBL3104858 Ki 375.0 nM
C#CCCCn1c(Sc2ccc(Br)cc2Cl)nc2c(N)ncnc21 CHEMBL3426733 IC50 390.0 nM
C#CCCn1c(Sc2ccc(Cl)cc2Cl)nc2c(N)ncnc21 CHEMBL3426756 IC50 390.0 nM
COC(=O)c1c(O)cc(O)c(Cl)c1CCc1nccn1Cc1ccno1 CHEMBL3804936 Kd 400.0 nM
CC(C)NCCCn1c(Sc2ccc(Cl)cc2Cl)nc2c(N)ncnc21 CHEMBL3426780 IC50 410.0 nM
CN1CCc2c3c(n(-c4ccc(C(N)=O)c(NC5CCSCC5)c4)c2C1)CC(C)(C)CC3=O CHEMBL3235338 Ki 420.0 nM
N#CCCCn1c(Sc2cc(Cl)cc(Cl)c2)nc2c(N)ncnc21 CHEMBL3426748 IC50 429.0 nM
C#CCCCn1c(Sc2ccc(Cl)c(Cl)c2Cl)nc2c(N)ncnc21 CHEMBL3426739 IC50 430.0 nM
COC(=O)c1c(O)cc(O)c(Cl)c1CCc1nccn1Cc1ccc(Cl)o1 CHEMBL3804872 Kd 440.0 nM
NC(=O)c1ccc(-n2cccc2Cc2ccccc2O)cc1N[C@H]1CC[C@H](O)CC1 CHEMBL4168274 Kd 440.0 nM
Nc1nc(Cl)c2cnn(Cc3cc4c(cc3Br)OCO4)c2n1 CHEMBL4068596 IC50 448.0 nM
COC(=O)c1c(O)cc(O)c(Cl)c1CCc1nccn1Cc1cccs1 CHEMBL3805768 Kd 470.0 nM
CCNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N)ncnc31)[C@H](O)[C@@H]2O CHEMBL27443 Ki 470.0 nM
CC1(C)CC(=O)c2c(C(F)(F)F)nn(-c3ccc(C(N)=O)c(N[C@H]4CC[C@H](O)CC4)c3)c2C1 CHEMBL560895 Ki 484.0 nM
Nc1nc(Cl)c2nc(O)n(Cc3ccc(Br)cc3F)c2n1 CHEMBL4866705 IC50 494.0 nM
COc1ncc2c(n1)CCN(C(=O)c1cc(C(C)C)c(O)cc1O)C2 CHEMBL4778735 IC50 498.0 nM
CCCOc1ncc2c(n1)CCN(C(=O)c1cc(C(C)C)c(O)cc1O)C2 CHEMBL4757080 IC50 498.0 nM
C#CCCCn1c(Sc2cc(C(F)(F)F)ccc2Cl)nc2c(N)ncnc21 CHEMBL364456 IC50 500.0 nM
C#CCCCn1c(Oc2ccc(Cl)cc2Cl)nc2c(N)ncnc21 CHEMBL3426761 IC50 500.0 nM
Nc1ncnc2c1nc(Sc1cc(Cl)cc(Cl)c1)n2CCCC(F)(F)F CHEMBL3426745 IC50 502.0 nM
CC(C)Oc1ncc2c(n1)CCN(C(=O)c1cc(C(C)C)c(O)cc1O)C2 CHEMBL4786802 IC50 518.0 nM
C#CCCCn1c(Sc2cc(Cl)ccc2Cl)nc2c(N)ncnc21 CHEMBL364450 IC50 530.0 nM
COC(=O)c1c(O)cc(O)c(Cl)c1CCc1nccn1Cc1ccco1 CHEMBL3805027 Kd 550.0 nM
Nc1ncnc2c1nc(Sc1cc(Cl)cc(Cl)c1)n2CCC(F)(F)F CHEMBL3426744 IC50 560.0 nM
CCOc1ncc2c(n1)CCN(C(=O)c1cc(C(C)C)c(O)cc1O)C2 CHEMBL4763114 IC50 561.0 nM
CN1CCc2c3c(n(-c4ccc(C(N)=O)c(NC5CCCC5)c4)c2C1)CC(C)(C)CC3=O CHEMBL3235335 Ki 580.0 nM
CCNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N)nc(Cl)nc31)[C@H](O)[C@@H]2O CHEMBL4741658 Ki 590.0 nM
Nc1ncnc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)NC3CC3(F)F)C[C@H]12 CHEMBL4794637 Ki 590.0 nM
CCOc1nc(OCCOC)nc2c1CN(C(=O)c1cc(C(C)C)c(O)cc1O)CC2 CHEMBL4793342 IC50 608.0 nM
CN1CCc2c3c(n(-c4ccc(C(N)=O)c(NCC5(C)COC5)c4)c2C1)CC(C)(C)CC3=O CHEMBL3235342 Ki 620.0 nM
COc1ccc(F)c(CN2C(=O)Cc3c(Cl)nc(N)nc32)c1F CHEMBL4850126 IC50 649.0 nM
COC(=O)c1c(O)cc(O)c(Cl)c1CCc1nccn1Cc1ccc(C)o1 CHEMBL3805428 Kd 650.0 nM
C#CCCCCn1c(Sc2cc(Cl)cc(Cl)c2)nc2c(N)ncnc21 CHEMBL3426742 IC50 665.0 nM
COC(=O)c1c(O)cc(O)c(Cl)c1CCc1nccn1Cc1cc(Cl)cs1 CHEMBL3805824 Kd 670.0 nM
CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N)nc(Cl)nc31)[C@H](O)[C@@H]2O CHEMBL4782644 Ki 670.0 nM
CCCCOc1ncc2c(n1)CCN(C(=O)c1cc(C(C)C)c(O)cc1O)C2 CHEMBL4796810 IC50 670.0 nM
COC(=O)c1c(O)cc(O)c(Cl)c1CCc1nccn1Cc1ccc(C)s1 CHEMBL3804875 Kd 680.0 nM
C#CCCCn1c(Sc2ccc(Cl)c(Cl)c2)nc2c(N)ncnc21 CHEMBL3426738 IC50 695.0 nM
C#CCCCn1c(Cc2ccc(Cl)cc2Cl)nc2c(N)ncnc21 CHEMBL3426762 IC50 700.0 nM
CC(C)COc1ncc2c(n1)CCN(C(=O)c1cc(C(C)C)c(O)cc1O)C2 CHEMBL4763426 IC50 706.0 nM
CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N)ncnc31)[C@H](O)[C@@H]2O CHEMBL4794716 Ki 710.0 nM
CCc1ccsc1Cn1ccnc1CCc1c(Cl)c(O)cc(O)c1C(=O)OC CHEMBL3805991 Kd 720.0 nM
CCNc1nc(OCCOC)nc2c1CN(C(=O)c1cc(C(C)C)c(O)cc1O)CC2 CHEMBL4797252 IC50 729.0 nM
COC(=O)c1c(O)cc(O)c(Cl)c1CCc1nccn1Cc1ccc(C)cc1 CHEMBL3805286 Kd 730.0 nM
C=Cc1ccsc1Cn1ccnc1CCc1c(Cl)c(O)cc(O)c1C(=O)OC CHEMBL3805350 Kd 750.0 nM
COC(=O)c1c(O)cc(O)c(Cl)c1CCc1nccn1Cc1sccc1Cl CHEMBL3804981 Kd 760.0 nM
COCCOc1nc2c(c(NC(C)C)n1)CN(C(=O)c1cc(C(C)C)c(O)cc1O)CC2 CHEMBL4753338 IC50 787.0 nM
CCCNc1nc(OCCOC)nc2c1CN(C(=O)c1cc(C(C)C)c(O)cc1O)CC2 CHEMBL4755251 IC50 796.0 nM
CCCCn1c(Sc2cc(Cl)cc(Cl)c2)nc2c(N)ncnc21 CHEMBL3426754 IC50 800.0 nM
COC(=O)c1c(O)cc(O)c(Cl)c1CCc1nccn1Cc1ccc(Cl)cc1 CHEMBL3804944 Kd 810.0 nM
CCc1ccccc1Cn1ccnc1CCc1c(Cl)c(O)cc(O)c1C(=O)OC CHEMBL3805146 Kd 810.0 nM
Nc1nc(Cl)c2c(n1)N(Cc1cc3c(cc1Br)OCO3)C(=O)C2 CHEMBL4870087 IC50 812.0 nM
COC(=O)c1c(O)cc(O)c(Cl)c1CCC(=O)Nc1ccccn1 CHEMBL3310671 Kd 820.0 nM
CN1CCc2c3c(n(-c4ccc(C(N)=O)c(NCC(C)(C)C)c4)c2C1)CC(C)(C)CC3=O CHEMBL3235344 Ki 840.0 nM
COc1cc(F)c(Cn2c(S)nc3c(Cl)nc(N)nc32)c(F)c1 CHEMBL4860652 IC50 840.0 nM
Nc1ncnc2c1nc1n2[C@@H]2O[C@H](CO1)[C@@H](O)[C@H]2O CHEMBL4748119 Ki 880.0 nM
C#CCC(CC)n1c(Sc2ccc(Cl)cc2Cl)nc2c(N)ncnc21 CHEMBL3426758 IC50 920.0 nM
CCCOc1nc(OCCOC)nc2c1CN(C(=O)c1cc(C(C)C)c(O)cc1O)CC2 CHEMBL4778049 IC50 929.0 nM
COC(=O)c1c(O)cc(O)c(Cl)c1CCc1nccn1Cc1ccc(Cl)s1 CHEMBL3805965 Kd 930.0 nM
COC(=O)c1c(O)cc(O)c(Cl)c1CCc1nccn1Cc1ccc(Br)cc1 CHEMBL3805621 Kd 960.0 nM
NC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N)nc(Cl)nc31)[C@H](O)[C@@H]2O CHEMBL4782467 Ki 960.0 nM
Nc1nc(Cl)c2nc(O)n(Cc3ccc(Cl)c(Cl)c3)c2n1 CHEMBL4879021 IC50 986.0 nM