CN1CCC(N(Cc2ccc(F)cc2)C(=O)NCc2ccc3c(c2)CC(C)(C)O3)CC1 CHEMBL5414859 pKi 0.002512 nM
CCC(=O)NC1CCc2ccc(CCN3CCN(c4nsc5ccccc45)CC3)cc21 CHEMBL253022 Ki 0.01 nM
CC(=O)NC1CCc2ccc(CCN3CCN(c4nsc5ccccc45)CC3)cc21 CHEMBL252818 Ki 0.01 nM
CCN(CC)C(=O)N[C@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1 CHEMBL157138 pEC50 0.02239 nM
Cn1nccc1-c1cc(NC(=O)C(=O)c2ccc(F)cc2)ccc1OCCN CHEMBL3652592 IC50 0.025 nM
CC1Cc2cc(CNC(=O)N(Cc3ccc(F)cc3)C3CCN(C)CC3)ccc2O1 CHEMBL5414080 pKi 0.03162 nM
CC(N)Cc1c2ccoc2c(Br)c2ccoc12 CHEMBL149024 Ki 0.04 nM
O=S1(=O)c2cccc3cccc(c23)N1CCCN1CCN(c2ccc(F)cc2)CC1 CHEMBL83894 Ki 0.04 nM
O=C(Cc1ccccc1)NC1CCc2ccc(CCN3CCN(c4nsc5ccccc45)CC3)cc21 CHEMBL253878 Ki 0.04 nM
CC1CC(=O)Nc2c(CCN3CCN(c4nsc5ccccc45)CC3)cc(Cl)cc21 CHEMBL194455 Ki 0.05 nM
Fc1ccc2c([C@@H]3CNCC[C@H]3F)c(-c3ccccc3)[nH]c2c1 CHEMBL504699 Ki 0.06 nM
CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCN(C)CC2)cc1 CHEMBL2111101 pKi 0.0631 nM
CC(O)c1ccccc1S(=O)(=O)c1ccc(/C=C/c2ccc(F)cc2)cc1 CHEMBL1084721 Ki 0.07 nM
CCN(C)CCc1c(-c2cccc(F)c2)[nH]c2ccccc12 CHEMBL328595 Ki 0.08 nM
O=C1Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)c(Cl)cc2N1 CHEMBL708 Ki 0.08 nM
O=C(NC1CCc2ccc(CCN3CCN(c4nsc5ccccc45)CC3)cc21)c1ccno1 CHEMBL251834 Ki 0.08 nM
COCCNCCOc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1c(Cl)cnn1C CHEMBL3665544 IC50 0.082 nM
Fc1ccc(-c2[nH]c3cc(F)ccc3c2C2CCCNC2)cc1 CHEMBL296512 Ki 0.09 nM
O=C(Nc1ccccc1)c1[nH]c2cc(F)ccc2c1[C@@H]1CNCC[C@H]1F CHEMBL497064 Ki 0.09 nM
NC1CCc2ccc(CCN3CCN(c4nsc5ccccc45)CC3)cc21 CHEMBL404000 Ki 0.09 nM
CN(C)CCc1sc2ccccc2c1Cc1ccc(F)cc1 CHEMBL540982 Ki 0.09 nM
O=C1CCc2ccc(OCCCCN3CCN(c4cccc5c4CCCC5)CC3)nc2N1 CHEMBL1774077 Ki 0.09 nM
CCOc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2 CHEMBL4758966 Ki 0.091 nM
Cc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2 CHEMBL4745124 Ki 0.094 nM
[3H]C([3H])([3H])Oc1cc(I)c(OC)cc1CCNCc1ccccc1OC([3H])([3H])[3H] CHEMBL482496 Kd 0.097 nM
Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2 CHEMBL85 Ki 0.099 nM
COc1ccc2[nH]cc(CCNCc3ccc(Br)cc3)c2c1 CHEMBL57427 Ki 0.1 nM
O=C(NC1CCc2ccc(CCN3CCN(c4nsc5ccccc45)CC3)cc21)c1ccc(Cl)cc1 CHEMBL253439 Ki 0.1 nM
COc1cccc([C@H](O)C2CCN(CCc3ccc(F)cc3)CC2)c1OC CHEMBL74355 pKi 0.1 nM
Fc1ccc2c([C@@H]3CNCC[C@H]3F)c(-c3ccsc3)[nH]c2c1 CHEMBL497054 Ki 0.11 nM
CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4c3c(cn4C)C[C@H]21 CHEMBL19215 Ki 0.113 nM
Fc1ccc(-c2[nH]c3cc(F)ccc3c2[C@@H]2CNCC[C@H]2F)cc1 CHEMBL523245 Ki 0.12 nM
COC1CCN(CCOc2ccc(NC(=O)Nc3ccc(Cl)cc3)cc2-c2ccnn2C)CC1 CHEMBL567889 Ki 0.12 nM
CCN(C)CCc1c(-c2cccc(C(F)(F)F)c2)[nH]c2ccccc12 CHEMBL90911 Ki 0.13 nM
Cc1ccc(CCN2CCN(c3nsc4ccccc34)CC2)c2c1C(C)CC(=O)N2 CHEMBL440389 Ki 0.13 nM
O=C(c1ccc(F)cc1)C1CCN(CCn2c(=S)[nH]c3ccccc3c2=O)CC1 CHEMBL62919 Ki 0.13 nM
O=C1CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nc2N1 CHEMBL1774063 Ki 0.13 nM
CCN(C)CCc1c(-c2ccccc2)[nH]c2ccccc12 CHEMBL91549 Ki 0.14 nM
CCN(C)CCc1c(-c2cccc([N+](=O)[O-])c2)[nH]c2ccccc12 CHEMBL90837 Ki 0.14 nM
CN(C)CCC1=C(Cc2ccc(F)cc2)c2ccccc2C1 CHEMBL560741 Ki 0.14 nM
O=C1CCc2ccc(OCCCCN3CCN(c4cccc5ccccc45)CC3)nc2N1 CHEMBL1774080 Ki 0.14 nM
O=C(Nc1cccnc1)N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1 CHEMBL3896937 Ki 0.14 nM
CCc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2 CHEMBL4760903 Ki 0.14 nM
C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(OC(F)(F)F)cc32)CCN1C CHEMBL4745489 Ki 0.14 nM
O=C(NC1CCc2cc(CCN3CCN(c4nsc5ccccc45)CC3)ccc21)C(F)(F)F CHEMBL398711 Ki 0.15 nM
Cn1nccc1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCCN1CCCC1 CHEMBL569510 Ki 0.15 nM
Cn1ncc(Cl)c1-c1cc(NC(=O)Nc2ccc(F)cc2F)ccc1OCCN1CCOCC1 CHEMBL569519 Ki 0.15 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1)c1cccs1 CHEMBL3976282 Ki 0.15 nM
COc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Cl)cnn1C CHEMBL610208 pKi 0.1585 nM
CC1COc2ccc(CNC(=O)N(Cc3ccc(F)cc3)C3CCN(C)CC3)cc21 CHEMBL5403965 pKi 0.1585 nM
O=C1CCc2ccc(OCCCCN3CCN(c4cccc5c4CCC5)CC3)nc2N1 CHEMBL1774076 Ki 0.16 nM
[11CH3]N1CCN(c2cccc3cc(S(=O)(=O)c4cccc(F)c4)cnc23)CC1 CHEMBL5201619 Ki 0.16 nM
CC1CC(=O)Nc2c(CCN3CCN(c4nsc5ccccc45)CC3)cc(F)cc21 CHEMBL197870 Ki 0.17 nM
CC1CC(=O)N(C)c2c(CCN3CCN(c4nsc5ccccc45)CC3)cccc21 CHEMBL372541 Ki 0.17 nM
N[C@@H](Cc1ccc(OCCCN2CCC(c3noc4cc(F)ccc34)CC2)cc1)C(=O)O CHEMBL5422180 IC50 0.17 nM
C[C@@H]1CCCCN1CCc1c(-c2ccccc2)[nH]c2ccccc12 CHEMBL90263 Ki 0.18 nM
O=C1CC(c2ccccc2)c2cccc(CCN3CCN(c4nsc5ccccc45)CC3)c2N1 CHEMBL438980 Ki 0.18 nM
CC1(C)CCNc2c(CCN3CCN(c4nsc5ccccc45)CC3)cccc21 CHEMBL194312 Ki 0.18 nM
Cn1ncc(Br)c1-c1cc(NC(=O)Nc2ccc(F)cc2F)ccc1OCCN1CCCC1 CHEMBL569518 Ki 0.18 nM
CCOC(=O)N[C@H]1CC[C@@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1 CHEMBL3923240 Ki 0.18 nM
CCN(C)CCc1c(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[nH]c2ccccc12 CHEMBL330303 Ki 0.19 nM
O=S(=O)(c1ccc(/C=C/c2ccc(F)cc2O)nc1)c1ccccc1F CHEMBL240876 Ki 0.19 nM
Cn1nccc1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCCN1CCOCC1 CHEMBL568107 Ki 0.19 nM
O=C1CCc2ccc(OCCCCN3CCN(c4cccc5c4OCCC5)CC3)nc2N1 CHEMBL1774079 Ki 0.19 nM
O=C(N[C@H]1CC[C@@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1)c1ccco1 CHEMBL3950977 Ki 0.19 nM
COc1ccc(NC(=O)Nc2ccc(Cl)cc2Cl)cc1-c1c(Br)cnn1C CHEMBL606178 pKi 0.1995 nM
COc1cc(CCNCc2cccc(OC)c2O)c(OC)cc1Br CHEMBL3589596 pKi 0.1995 nM
COc1cc(CCNCc2cccc3c2OCC3)c(OC)cc1Br CHEMBL3589582 pKi 0.1995 nM
Nc1cc(F)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCO3 CHEMBL165780 Ki 0.2 nM
NC(=O)c1cccc(S(=O)(=O)c2ccc(/C=C/c3ccc(F)cc3F)cc2)c1 CHEMBL1086507 Ki 0.2 nM
CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(F)(F)F)cc2)CC1 CHEMBL5205903 Ki 0.2 nM
CN1CCC(=C2c3ccccc3CCc3sccc32)CC1 CHEMBL294951 AC50 0.2 nM
CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 CHEMBL3187365 AC50 0.2 nM
N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1 CHEMBL3891773 Ki 0.21 nM
O=C(Nc1ccccc1)N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1 CHEMBL3918755 Ki 0.21 nM
CC1CC(=O)Nc2c(CCN3CCN(c4nsc5ccccc45)CC3)cccc21 CHEMBL371289 Ki 0.22 nM
Cn1nccc1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCCN1CCCOCC1 CHEMBL569509 Ki 0.22 nM
C[C@H](O)c1ccccc1S(=O)(=O)c1ccc(/C=C/c2ccc(F)cc2)cc1 CHEMBL1084976 Ki 0.22 nM
Fc1ccc2c([C@@H]3CNCC[C@H]3F)c(-c3ccc4ccccc4c3)[nH]c2c1 CHEMBL496860 Ki 0.23 nM
O=C(c1ccc(F)cc1)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1 CHEMBL51 Ki 0.23 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1)c1ccco1 CHEMBL3946995 Ki 0.23 nM
NCCc1c[nH]c2ccc(O)cc12 CHEMBL39 EC50 0.23 nM
CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1 CHEMBL193639 Ki 0.24 nM
COCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1 CHEMBL3903560 Ki 0.24 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1)c1ccccc1 CHEMBL3920252 Ki 0.24 nM
O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2o1 CHEMBL4753094 pKi 0.2455 nM
Cn1ccc2cc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)ccc21 CHEMBL4759492 pKi 0.2455 nM
O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2ccccc2c1 CHEMBL4747225 pKi 0.2455 nM
O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc2ccccc2c1 CHEMBL5084167 pKi 0.2455 nM
Fc1ccc2c([C@@H]3CNCC[C@H]3F)c(C3CCCCC3)[nH]c2c1 CHEMBL507898 Ki 0.25 nM
CCC(=O)NC1CCc2cc(CCN3CCN(c4nsc5ccccc45)CC3)ccc21 CHEMBL252031 Ki 0.25 nM
Cn1nccc1-c1cc(NC(=O)Nc2cccc(C(F)(F)F)c2)ccc1OCCN1CCCCC1 CHEMBL565322 Ki 0.25 nM
COc1ccc(NC(=O)Nc2cccc(Cl)c2)cc1-c1c(Br)cnn1C CHEMBL602874 pKi 0.2512 nM
COc1ccc(NC(=O)Nc2ccc(F)cc2)cc1-c1c(Br)cnn1C CHEMBL603078 pIC50 0.2512 nM
COc1ccc(NC(=O)Nc2ccc(Br)cc2)cc1-c1c(Br)cnn1C CHEMBL599225 pKi 0.2512 nM
COc1ccc(NC(=O)Nc2ccc(F)cc2)cc1-c1c(Br)cnn1C(C)C CHEMBL606622 pKi 0.2512 nM
CCOc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Br)cnn1C CHEMBL599193 pKi 0.2512 nM
COc1ccc(NC(=O)Nc2ccc(F)c(F)c2)cc1-c1c(Cl)cnn1C CHEMBL603061 pKi 0.2512 nM
COC[C@@H]1CCCN1CCc1c(-c2ccccc2)[nH]c2ccccc12 CHEMBL91446 Ki 0.26 nM
Cn1ncc(Cl)c1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCCN1CCCC1 CHEMBL571915 Ki 0.26 nM
Cc1ccc(S(=O)(=O)N[C@H]2CC[C@H](CCN3CCN(c4nsc5ccccc45)CC3)CC2)cc1 CHEMBL3948056 Ki 0.26 nM
Cn1ncc(Cl)c1-c1cc(NC(=O)C2CCC(C(F)(F)F)CC2)ccc1OCCN CHEMBL3652595 IC50 0.26 nM
CN1CCC(=C2c3ccccc3C=Cc3ccccc32)CC1 CHEMBL516 Ki 0.278 nM
O=C1CCc2cccc(CCN3CCN(c4nsc5ccccc45)CC3)c2N1 CHEMBL371903 Ki 0.28 nM
Cc1cc(CCN2CCN(c3noc4ccccc34)CC2)c2c(c1)C(C)CC(=O)N2 CHEMBL198599 Ki 0.28 nM
CC1CC(=O)Nc2c(CCN3CCN(c4noc5ccccc45)CC3)cc(F)cc21 CHEMBL371628 Ki 0.28 nM
CC1(C)CCNc2c(CCN3CCN(c4nsc5ccccc45)CC3)cc(F)cc21 CHEMBL363829 Ki 0.28 nM
Cn1ncc(Br)c1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCCN1CCCC1 CHEMBL569475 Ki 0.28 nM
Cn1ncc(Cl)c1-c1cc(NC(=O)Nc2ccc(F)cc2F)ccc1OCCN1CCCC1 CHEMBL566151 Ki 0.28 nM
O=C1CCc2ccc(OCCCCN3CCN(c4cccc5ccc(F)cc45)CC3)nc2N1 CHEMBL1774086 Ki 0.28 nM
CS(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1 CHEMBL3892440 Ki 0.28 nM
CC(=O)N1CCC(C)c2cc(F)cc(CCN3CCN(c4noc5ccccc45)CC3)c21 CHEMBL370659 Ki 0.29 nM
COc1cc(C[C@@H](C)N)c(OC)cc1Br CHEMBL69700 Ki 0.29 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1)c1ccc[nH]1 CHEMBL3938210 Ki 0.29 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1)c1cccnc1 CHEMBL3967779 Ki 0.29 nM
COc1cc(CCNCc2ccccc2)c(OC)cc1Br CHEMBL292692 Ki 0.3 nM
Nc1cc(F)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCS3 CHEMBL354005 Ki 0.3 nM
CCN(C)CCc1c(-c2ccccc2F)[nH]c2ccccc12 CHEMBL91197 Ki 0.3 nM
O=S(=O)(c1cccc(F)c1)C1(F)CCN(CCc2ccc(F)cc2F)CC1 CHEMBL177401 Ki 0.3 nM
CC(=O)N1CCC(C)c2cccc(CCN3CCN(c4nsc5ccccc45)CC3)c21 CHEMBL369913 Ki 0.3 nM
O=C(NC1CCc2ccc(CCN3CCN(c4nsc5ccccc45)CC3)cc21)C1CC1 CHEMBL253024 Ki 0.3 nM
O=S(=O)(N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1)c1cccs1 CHEMBL3966842 Ki 0.3 nM
Cc1cc(=O)oc2c(Cl)c(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12 CHEMBL2387229 Ki 0.3 nM
O=c1ccc(OCCCN2CCC(c3noc4cc(F)ccc34)CC2)nn1-c1c(F)cccc1F CHEMBL3883955 Ki 0.3 nM
COc1cc(C(C)=O)ccc1OCCCN1CCC(c2noc3cc(F)ccc23)CC1 CHEMBL14376 AC50 0.3 nM
CC(=O)N1CCC(C)c2cc(Cl)cc(CCN3CCN(c4nsc5ccccc45)CC3)c21 CHEMBL199182 Ki 0.31 nM
Cn1ncc(Cl)c1-c1cc(NC(=O)Nc2cc(F)cc(F)c2)ccc1OCCN1CCOCC1 CHEMBL576055 Ki 0.31 nM
O=C1NCN(c2ccccc2)C12CCN(CCCOc1ccc(F)cc1)CC2 CHEMBL79834 Log IC50 0.3162 nM
COc1ccc(NC(=O)Nc2cccc(F)c2)cc1-c1c(Br)cnn1C CHEMBL602064 pKi 0.3162 nM
COc1ccc(NC(=O)Nc2ccc(C(F)(F)F)cc2)cc1-c1c(Br)cnn1C CHEMBL606191 pKi 0.3162 nM
COc1ccc(NC(=O)Nc2ccc(C(C)C)cc2)cc1-c1c(Br)cnn1C CHEMBL596976 pKi 0.3162 nM
CC(C)Oc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Br)cnn1C CHEMBL599194 pKi 0.3162 nM
COc1ccc(NC(=O)Nc2cc(F)cc(F)c2)cc1-c1c(Br)cnn1C CHEMBL598171 pKi 0.3162 nM
COc1ccc(NC(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1-c1c(Br)cnn1C CHEMBL602873 pKi 0.3162 nM
O=S(=O)(c1ccccc1F)C1(F)CCN(CCc2ccc(F)cc2F)CC1 CHEMBL177416 Ki 0.32 nM
CC(=O)N1CCC(C)c2c(C)ccc(CCN3CCN(c4noc5ccccc45)CC3)c21 CHEMBL197663 Ki 0.32 nM
O=C(NC[C@H]1CC[C@H](CN2CCN(c3nsc4cc(Cl)ccc34)CC2)CC1)c1ccco1 CHEMBL3932186 Ki 0.32 nM
O=S(=O)(c1ccccc1)C1CCN(CCc2ccc(F)cc2F)CC1 CHEMBL145939 Ki 0.33 nM
CC(=O)NC1CCc2cc(CCN3CCN(c4nsc5ccccc45)CC3)ccc21 CHEMBL252030 Ki 0.33 nM
Cn1nccc1-c1cc(NC(=O)Nc2cccc(Cl)c2)ccc1OCCN1CCCCC1 CHEMBL565321 Ki 0.33 nM
O=C(NCCCCN1CCN(c2cccc3ccccc23)CC1)c1cnc2ccccc2c1 CHEMBL3597635 Ki 0.33 nM
O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2ccccc2c1 CHEMBL4763085 pKi 0.3311 nM
Fc1ccc2c([C@@H]3CNCC[C@H]3F)c(-c3cccc4ccccc34)[nH]c2c1 CHEMBL496687 Ki 0.34 nM
Cn1nccc1-c1cc(NC(=O)Nc2ccc(C(F)(F)F)cc2)ccc1OCCN1CCCCC1 CHEMBL568842 Ki 0.34 nM
CCCS(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1 CHEMBL3920432 Ki 0.34 nM
O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2o1 CHEMBL4764006 pKi 0.3467 nM
NCCc1c[nH]c2ccc(O)cc12 CHEMBL535832 pEC50 0.3467 nM
Fc1ccc2c([C@@H]3CNCC[C@H]3F)c(-c3cccnc3)[nH]c2c1 CHEMBL523760 Ki 0.35 nM
COc1cc(Br)c(OC)c2c1[C@H](CN)C2 CHEMBL379637 Ki 0.35 nM
Cc1cccc(N2CCN(CCCCOc3ccc4c(n3)NC(=O)CC4)CC2)c1C CHEMBL1774071 Ki 0.35 nM
CN(C(=O)N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1)c1ccccc1 CHEMBL3953773 Ki 0.35 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1)C1CC1 CHEMBL3956720 Ki 0.35 nM
COc1ccc2c(c1)CCC1(CCN(CCCC(=O)c3ccc(F)cc3)CC1)O2 CHEMBL357807 Ki 0.36 nM
Cn1ncc(Br)c1-c1cc(NC(=O)Nc2ccc(F)cc2)ccc1OCCN1CCCC1 CHEMBL583624 Ki 0.36 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1)C1CCCCC1 CHEMBL3929168 Ki 0.36 nM
CC(C)N(C(=O)N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1)C(C)C CHEMBL3900752 Ki 0.38 nM
O=S(=O)(c1ccc(F)cc1)C1(F)CCN(CCc2ccc(F)cc2F)CC1 CHEMBL175832 Ki 0.39 nM
CN1CCN(c2cccc3cc(S(=O)(=O)c4cccc(F)c4)cnc23)CC1 CHEMBL3260313 Ki 0.39 nM
CN1CCC(N(Cc2ccc(F)cc2)C(=O)NCc2ccc(OCC(O)CN3CCC(c4noc5cc(F)ccc45)CC3)cc2)CC1 CHEMBL4635010 IC50 0.39 nM
COc1ccc(NC(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1c(Br)cnn1C CHEMBL599226 pIC50 0.3981 nM
COc1ccc(NC(=O)Nc2ccc(OC)c(-c3c(Br)cnn3C)c2)cc1 CHEMBL603609 pIC50 0.3981 nM
Cn1ncc(Br)c1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1O CHEMBL605636 pKi 0.3981 nM
COc1ccc(NC(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1-c1c(Br)cnn1C CHEMBL599828 pKi 0.3981 nM
O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(F)cc2s1 CHEMBL4754193 pKi 0.3981 nM
COc1cc(CCNCc2ccc(Br)cc2)c(OC)cc1Br CHEMBL294902 Ki 0.4 nM
COc1cc(CCNCc2ccc(I)cc2)c(OC)cc1Br CHEMBL57939 Ki 0.4 nM
Nc1cc(F)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCCS3 CHEMBL166310 Ki 0.4 nM
OC1c2ccccc2CCC12CCN(CCc1ccccc1)CC2 CHEMBL146144 Ki 0.4 nM
Cc1ccc(-c2nc(Cc3ccccc3)nc3c2CCNCC3)cc1 CHEMBL269974 Ki 0.4 nM
O=C(c1cccc2ccnn12)N1CCN(CCc2ccc(F)cc2F)CC1 CHEMBL1957805 Ki 0.4 nM
Cc1cccc(S(=O)(=O)NCCCCN2CCN(c3nsc4ccccc34)CC2)c1 CHEMBL3289944 Ki 0.4 nM
O=S1(=O)c2ccccc2CCC12CCN(CCc1ccc(F)cc1F)CC2 CHEMBL146595 Ki 0.41 nM
Cn1nccc1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCCN1CCCCC1 CHEMBL567888 Ki 0.41 nM
O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1csc2ccccc12 CHEMBL4793608 pKi 0.4169 nM
O=S(=O)(c1ccc(F)cc1)C1CCN(CCc2ccc(F)cc2F)CC1 CHEMBL358075 Ki 0.42 nM
Cn1nccc1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCCN1CCC(O)CC1 CHEMBL567246 Ki 0.42 nM
Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1 CHEMBL715 Ki 0.42 nM
F[C@@H]1CCNC[C@H]1c1c(-c2ccccc2)[nH]c2ccccc12 CHEMBL497877 Ki 0.43 nM
CCN(C)CCc1c(-c2ccc(F)cc2)[nH]c2ccccc12 CHEMBL328459 Ki 0.43 nM
Cn1ncc(Cl)c1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCCN1CCCCC1 CHEMBL585312 Ki 0.43 nM
CCN(CC)CCOc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1ccnn1C CHEMBL568841 Ki 0.43 nM
COc1cccc(CNCCc2cc(OC)c(Br)cc2OC)c1 CHEMBL3589597 pKi 0.4365 nM
CC(=O)N1CCC(C)c2cc(F)cc(CCN3CCN(c4nsc5ccccc45)CC3)c21 CHEMBL372811 Ki 0.44 nM
Clc1ccc2c(c1)C(N1CCNCC1)=Nc1ccccc1O2 CHEMBL1113 Ki 0.444 nM
Cn1ccc2cc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)ccc21 CHEMBL4785434 pKi 0.4467 nM
O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc2ccccc12 CHEMBL4754138 pKi 0.4467 nM
O=C(NC1CCc2cc(CCN3CCN(c4nsc5ccccc45)CC3)ccc21)C1CC1 CHEMBL252230 Ki 0.45 nM
CCCC(=O)NC1CCc2ccc(CCN3CCN(c4nsc5ccccc45)CC3)cc21 CHEMBL400235 Ki 0.45 nM
Cc1nc2sccn2c(=O)c1CCN1CCC(=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1 CHEMBL267777 Ki 0.45 nM
COc1cc(CC(C)N)c(OC)cc1I CHEMBL6616 Ki 0.46 nM
Fc1cccc2c([C@@H]3CNCC[C@H]3F)c(-c3ccccc3)[nH]c12 CHEMBL498729 Ki 0.46 nM
O=c1ccc2ccc(OCCCCN3CCN(c4cccc5sccc45)CC3)cc2[nH]1 CHEMBL2105760 Ki 0.47 nM
CC(N)Cc1c2c(c(Br)c3c1OCC3)OCC2 CHEMBL101008 Ki 0.48 nM
c1ccc(CCN2CCC(c3c(-c4ccccc4)[nH]c4ccccc34)CC2)cc1 CHEMBL40584 Ki 0.48 nM
C[C@@H](N)Cc1c2c(c(Br)c3c1OCC3)OCC2 CHEMBL305275 Ki 0.48 nM
N#Cc1c[nH]c2c(C(=O)N3CCN(CCc4ccc(F)cc4)CC3)cccc12 CHEMBL1215661 Ki 0.48 nM
Fc1ccc2cccc(N3CCN(CCCCOc4ccc5c(c4)CNC5)CC3)c2c1 CHEMBL1258532 Ki 0.483 nM
COc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)c(O)c1 CHEMBL5198213 pEC50 0.4898 nM
Nc1cc(F)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCC3 CHEMBL351592 Ki 0.5 nM
NC(=O)c1cccc(S(=O)(=O)C2CCN(CCc3ccc(F)cc3F)CC2)c1 CHEMBL146485 Ki 0.5 nM
CCCC(=O)NC1CCc2cc(CCN3CCN(c4nsc5ccccc45)CC3)ccc21 CHEMBL252228 Ki 0.5 nM
CN(C)CCOC1=Cc2ccccc2Sc2ccc(Cl)cc21 CHEMBL285802 Ki 0.5 nM
O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1 CHEMBL602284 IC50 0.5 nM
Cc1cccc(N2CCN(CCCCOc3ccc4c(n3)NC(=O)CC4)CC2)c1Cl CHEMBL1774069 Ki 0.5 nM
O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1 CHEMBL3290012 Ki 0.5 nM
CCN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1 CHEMBL3971907 Ki 0.5 nM
COc1cc(CCNCc2ccccc2O[11CH3])c(OC)cc1Br CHEMBL5203398 Ki 0.5 nM
COc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Br)cnn1C CHEMBL591223 pKi 0.5012 nM
COc1ccc(NC(=O)Nc2cccc(C#N)c2)cc1-c1c(Br)cnn1C CHEMBL608425 pKi 0.5012 nM
COc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Br)cnn1C(C)C CHEMBL604586 pKi 0.5012 nM
COc1ccc(NC(=O)Nc2ccc(Cl)cc2C(F)(F)F)cc1-c1c(Br)cnn1C CHEMBL604082 pKi 0.5012 nM
COc1ccc2[nH]cc(CCN)c2c1 CHEMBL8165 EC50 0.503 nM
CN1CCN2c3ccccc3Cc3ccccc3C2C1 CHEMBL6437 Ki 0.504 nM
O=C(c1ccc(F)cc1)C1CCN(CCc2cccc(I)c2)CC1 CHEMBL306478 Ki 0.51 nM
COc1ccc(NC(=O)Nc2ccc(F)cc2F)cc1-c1c(Br)cnn1C CHEMBL598172 Ki 0.51 nM
COc1cccc(C(=O)Nc2ccc(OCCO)c(-c3c(Cl)cnn3C)c2)c1 CHEMBL3665547 IC50 0.51 nM
NC(=O)c1ccc(S(=O)(=O)C2CCN(CCc3ccc(F)cc3F)CC2)cc1 CHEMBL148058 Ki 0.52 nM
COc1cccc(C(=O)C2CCN(CCc3ccc(F)cc3)CC2)c1OC CHEMBL4638006 Ki 0.52 nM
N#Cc1ccccc1S(=O)(=O)C1CCN(CCc2ccc(F)cc2F)CC1 CHEMBL146998 Ki 0.53 nM
CCOC(=O)N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1 CHEMBL3982486 Ki 0.53 nM
Fc1ccc2c([C@@H]3CNCC[C@H]3F)c(-c3ccoc3)[nH]c2c1 CHEMBL2368734 Ki 0.54 nM
COc1ccc(NC(=O)Nc2ccc(OCCN3CCCCC3)c(-c3ccnn3C)c2)cc1 CHEMBL568314 Ki 0.54 nM
CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12 CHEMBL3233142 Ki 0.54 nM
CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12 CHEMBL3306803 IC50 0.54 nM
O=C(NC1CCc2ccc(CCN3CCN(c4nsc5ccccc45)CC3)cc21)c1ccco1 CHEMBL398744 Ki 0.55 nM
CCN(CC)CCCOc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1ccnn1C CHEMBL566593 Ki 0.55 nM
NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 CHEMBL1909072 Ki 0.554 nM
O=C1c2ccoc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1 CHEMBL164471 pKi 0.5623 nM
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5cccc(F)c45)CC3)c(F)c21 CHEMBL1258199 Ki 0.568 nM
Cn1nccc1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCCN1CCSCC1 CHEMBL585924 Ki 0.58 nM
Cc1ccc2sc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)cc2c1 CHEMBL4748379 pKi 0.5888 nM
CC1CCN(C(=O)C2CCCCC2)c2c(CCN3CCN(c4nsc5ccccc45)CC3)cccc21 CHEMBL197677 Ki 0.59 nM
Nc1cc(F)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCCC3 CHEMBL349683 Ki 0.6 nM
Nc1ccccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCCS3 CHEMBL164185 Ki 0.6 nM
O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1 CHEMBL12713 Ki 0.6 nM
Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CCNCC3)cc1 CHEMBL270188 Ki 0.6 nM
CN(C)CCC1=C(Cc2cnccn2)c2ccccc2C1 CHEMBL559251 Ki 0.6 nM
Cn1nccc1-c1cc(NC(=O)c2cccc(C(F)(F)F)c2)ccc1OCCN1CCCC1 CHEMBL1085155 Ki 0.6 nM
Cn1ncc(Cl)c1-c1cc(NC(=O)c2cccc(F)c2)ccc1OCCN1CCOCC1 CHEMBL1086075 Ki 0.6 nM
O=C(c1nn2ccccc2c1Cl)N1CCN(CCc2ccc(F)cc2F)CC1 CHEMBL1957802 Ki 0.6 nM
Clc1cccc(C2CCN(CCCCOc3ccc4scnc4c3)CC2)c1Cl CHEMBL2165137 Ki 0.6 nM
O=C1CCc2ccc(OCCCCN3CCCN(c4cccc(Cl)c4Cl)CC3)cc2N1 CHEMBL2165126 Ki 0.6 nM
O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12 CHEMBL3290003 Ki 0.6 nM
O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2cc(Cl)ccc2c1 CHEMBL3290008 Ki 0.6 nM
CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1 CHEMBL3960785 Ki 0.6 nM
COc1cc(CC(C)N)c(OC)cc1Br CHEMBL6607 Ki 0.6 nM
O=C1C2CC=CCC2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1 CHEMBL4287980 IC50 0.6 nM
CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCNCC2)cc1 CHEMBL4644559 IC50 0.6 nM
COc1cc(CCNCc2cccc3c2OCO3)c(OC)cc1Br CHEMBL3589578 pKi 0.6026 nM
COc1cc(CCNCc2cccc3ccoc23)c(OC)cc1Br CHEMBL3589579 pKi 0.6026 nM
Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12 CHEMBL194837 IC50 0.61 nM
CC1CCN(C(=O)c2ccccc2)c2c(CCN3CCN(c4nsc5ccccc45)CC3)cccc21 CHEMBL194953 Ki 0.61 nM
Cn1ncc(Cl)c1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCCN1CCOCC1 CHEMBL568313 Ki 0.61 nM
Cn1ncc(Br)c1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCCN1CCOCC1 CHEMBL571917 Ki 0.63 nM
C[C@@H](CO)NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1 CHEMBL119443 Ki 0.63 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1)C(F)(F)F CHEMBL3913691 Ki 0.63 nM
COc1ccc(NC(=O)Nc2ccc(F)cc2F)cc1-c1c(Cl)cnn1C CHEMBL598173 pKi 0.631 nM
Fc1ccc2c(c1Cc1ccccc1)CCC1CNCCN21 CHEMBL3956394 pKi 0.631 nM
O=S(=O)(c1ccc(Cl)cc1)C1(F)CCN(CCc2ccc(F)cc2F)CC1 CHEMBL175544 Ki 0.64 nM
Clc1cccc(N2CCN(CCCCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl CHEMBL3613880 Ki 0.64 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1)c1cc2ccccc2[nH]1 CHEMBL3905247 Ki 0.64 nM
CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 CHEMBL4128926 IC50 0.64 nM
C[C@H]1C[C@H](NS(=O)(=O)c2cc3ccc(F)cc3s2)CN1CCCc1noc2cc(F)ccc12 CHEMBL5076846 pKi 0.6457 nM
COc1cc(C[C@@H](C)N)c(OC)cc1I CHEMBL134519 Ki 0.65 nM
CC(C)C(=O)NC1CCc2cc(CCN3CCN(c4nsc5ccccc45)CC3)ccc21 CHEMBL398525 Ki 0.65 nM
NC(=O)c1ccccc1S(=O)(=O)c1ccc(/C=C/c2ccc(F)cc2F)cc1 CHEMBL1083416 Ki 0.65 nM
NC(=O)c1ccc(S(=O)(=O)c2ccc(/C=C/c3ccc(F)cc3F)cc2)cc1 CHEMBL1082467 Ki 0.65 nM
N#Cc1cccc(S(=O)(=O)C2CCN(CCc3ccc(F)cc3F)CC2)c1 CHEMBL147048 Ki 0.66 nM
O=S(=O)(c1ccc(-n2ccnn2)cc1)C1(F)CCN(CCc2ccc(F)cc2F)CC1 CHEMBL174049 Ki 0.66 nM
COc1cc(CCN)c(OC)cc1Br CHEMBL292821 Ki 0.66 nM
Cn1ncc(Br)c1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCCN1CCCCC1 CHEMBL567877 Ki 0.66 nM
O=C1CCc2ccc(OCCCCN3CCN(c4cccc5cccc(F)c45)CC3)nc2N1 CHEMBL1774087 Ki 0.67 nM
O=S(=O)(c1ccccc1)C1(F)CCN(CCc2ccc(F)cc2F)CC1 CHEMBL175586 Ki 0.68 nM
O=C(NC1CCc2cc(CCN3CCN(c4nsc5ccccc45)CC3)ccc21)c1cccnc1 CHEMBL252430 Ki 0.68 nM
F[C@@H]1CCNC[C@H]1c1c(-c2ccccc2)[nH]c2c(Cl)cccc12 CHEMBL523585 Ki 0.69 nM
Cn1nccc1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCCN1CCC1 CHEMBL568104 Ki 0.69 nM
C[C@H]1C[C@H](NS(=O)(=O)c2cc3ccccc3s2)CN1CCCc1noc2cc(F)ccc12 CHEMBL5090557 pKi 0.6918 nM
Nc1ccccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCCC3 CHEMBL352194 Ki 0.7 nM
[O-][S+](c1ccccc1)c1ccc(/C=C/c2ccc(F)cc2F)nc1 CHEMBL240887 Ki 0.7 nM
Fc1ccc(Cc2nc3c(c(-c4ccc(F)cc4)n2)CCNCC3)cc1 CHEMBL402164 Ki 0.7 nM
O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1 CHEMBL600012 IC50 0.7 nM
Cn1nccc1-c1cc(NC(=O)c2cccc(C(F)(F)F)c2)ccc1OCCN1CCOCC1 CHEMBL1086317 Ki 0.7 nM
O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2ccccc2c1 CHEMBL3289978 Ki 0.7 nM
O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12 CHEMBL3290001 Ki 0.7 nM
Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12 CHEMBL3290016 Ki 0.7 nM
O=C(CCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2 CHEMBL4289498 Ki 0.7 nM
Fc1ccc2cccc(N3CCN(CCCOc4ccc5c(c4)CNC5)CC3)c2c1 CHEMBL1258426 Ki 0.72 nM
O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2 CHEMBL4293999 Ki 0.72 nM
CC[C@@H](CO)NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1 CHEMBL1201356 Ki 0.728 nM
COc1cc(Br)c(OC)c2c1C(CN)C2 CHEMBL212197 Ki 0.73 nM
O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 CHEMBL1108 Ki 0.738 nM
O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2s1 CHEMBL4764468 pKi 0.7413 nM
CC(=O)N1CCC(C)c2c(C)ccc(CCN3CCN(c4nsc5ccccc45)CC3)c21 CHEMBL197990 Ki 0.75 nM
CC(C)C(=O)NC1CCc2ccc(CCN3CCN(c4nsc5ccccc45)CC3)cc21 CHEMBL400236 Ki 0.75 nM
Cc1cc2c(ccc3cnn(C[C@H](C)N)c32)o1 CHEMBL408579 Ki 0.78 nM
C[C@H](N)Cn1ncc2ccc3occc3c21 CHEMBL261476 Ki 0.78 nM
O=C1CCc2ccc(CCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nc2N1 CHEMBL1774062 Ki 0.79 nM
Cn1ncc(Br)c1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OC(F)(F)F CHEMBL596735 pKi 0.7943 nM
CC(C)COc1ccc(CN(Cc2ccc(F)cc2)C(=O)NC2CCN(C)CC2)cc1 CHEMBL3907928 pIC50 0.7943 nM
O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(Cl)cc2s1 CHEMBL4751063 pKi 0.7943 nM
Cc1c(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(F)cc12 CHEMBL4747978 pKi 0.7943 nM
Nc1ccccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCC3 CHEMBL348977 Ki 0.8 nM
Nc1ccccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCS3 CHEMBL163742 Ki 0.8 nM
CC(=O)Nc1cc(F)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCCS3 CHEMBL162768 Ki 0.8 nM
CCC1(NC2=NCCNC(c3ccc(F)cc3)=C2)CCCC1 CHEMBL221250 IC50 0.8 nM
FC(F)(F)c1ccc(-c2nc(Cc3ccccc3)nc3c2CCNCC3)cc1 CHEMBL271418 Ki 0.8 nM
O=C1CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2N1 CHEMBL1112 Ki 0.8 nM
O=C(c1nn2ccccc2c1Br)N1CCN(CCc2ccc(F)cc2F)CC1 CHEMBL1957801 Ki 0.8 nM
O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccc(Cl)cc2s1 CHEMBL3290014 Ki 0.8 nM
CCN1CCN(c2cc(-c3ccc(F)cc3)c3c(n2)CCCCCC3)CC1 CHEMBL178803 Ki 0.81 nM
O=S1(=O)N(CCN2CC=C(c3c[nH]c4cc(F)ccc34)CC2)c2cccc3c2N1CCC3 CHEMBL1079460 Ki 0.81 nM
Cn1nccc1-c1cc(NC(=O)Nc2cccc(F)c2)ccc1OCCN1CCOCC1 CHEMBL585387 Ki 0.82 nM
CC1CCCCN1CCOc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1ccnn1C CHEMBL569484 Ki 0.84 nM
Cn1nccc1-c1cc(NC(=O)Nc2ccc(F)cc2)ccc1OCCN1CCCCC1 CHEMBL567672 Ki 0.84 nM
[2H]c1c([2H])c([2H])c([C@@H]2C[C@@H](N3CCNC(C)(C)C3)c3cc(Cl)ccc32)c([2H])c1[2H] CHEMBL5201983 Ki 0.84 nM
O=S(=O)(c1ccccc1)c1ccc(/C=C/c2ccc(F)cc2F)nc1 CHEMBL1162962 Ki 0.86 nM
CCN(CC)CCOc1ccc(NC(=O)Nc2ccc(F)cc2)cc1-c1ccnn1C CHEMBL569067 Ki 0.86 nM
N#Cc1c[nH]c2c(C(=O)N3CCN(CCc4ccc(F)cc4F)CC3)cccc12 CHEMBL207566 Ki 0.87 nM
CCCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1 CHEMBL3962525 Ki 0.87 nM
CN1CCC(N(Cc2ccc(F)cc2)C(=O)NCc2ccc(OCC(O)CN3CCN(c4nsc5ccccc45)CC3)cc2)CC1 CHEMBL4647697 IC50 0.87 nM
O=C(CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCO3)c1ccc(F)cc1 CHEMBL3233432 Ki 0.89 nM
Nc1cc(F)ccc1C(=O)CCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CCCC3 CHEMBL165897 Ki 0.9 nM
CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3Cl)c3ccccc32)CC1 CHEMBL378669 Ki 0.9 nM
O=S(=O)(NCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1 CHEMBL3289952 Ki 0.9 nM
O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1 CHEMBL3290011 Ki 0.9 nM
O=C1NCc2ccc(OCCCN3CCN(c4cccc5ccc(F)cc45)CC3)c(F)c21 CHEMBL1258200 Ki 0.904 nM
OC(c1ccc(F)cc1)C1CCN(CCc2ccccc2I)CC1 CHEMBL77855 Ki 0.91 nM
Cn1nccc1-c1cc(NC(=O)Nc2cc(F)cc(F)c2)ccc1OCCN1CCCCC1 CHEMBL585142 Ki 0.91 nM
O=C(NCc1ccccc1)N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1 CHEMBL3940712 Ki 0.91 nM
COc1ccc2cc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)ccc2c1 CHEMBL4744007 pKi 0.9333 nM
O=C(CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCN3)c1ccc(F)cc1 CHEMBL3233143 Ki 0.94 nM
O=C(CCc1ccccc1)NC1CCc2ccc(CCN3CCN(c4nsc5ccccc45)CC3)cc21 CHEMBL252201 Ki 0.95 nM
O=C(NC1CCc2ccc(CCN3CCN(c4nsc5ccccc45)CC3)cc21)c1cccnc1 CHEMBL398619 Ki 0.95 nM
CC(=O)N1CCN(CCOc2ccc(NC(=O)Nc3ccc(Cl)cc3)cc2-c2ccnn2C)CC1 CHEMBL584924 Ki 0.96 nM
[2H]c1c([2H])c([2H])c([C@@H]2C[C@@H](N3CCN(C([2H])([2H])[2H])C(C)(C)C3)c3cc(Cl)ccc32)c([2H])c1[2H] CHEMBL5191141 Ki 0.96 nM
c1ccc(-c2[nH]c3ccccc3c2C2CCCNC2)cc1 CHEMBL42557 Ki 0.99 nM
COC1CN(CCOc2ccc(NC(=O)Nc3ccc(Cl)cc3)cc2-c2ccnn2C)C1 CHEMBL585140 Ki 0.99 nM
Cn1nccc1-c1cc(NC(=O)Nc2cccc(F)c2)ccc1OCCN1CCCCC1 CHEMBL584069 Ki 0.99 nM
COc1ccc(-c2ccccc2)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O CHEMBL93862 Log Ki 1.0 nM
O=S(=O)(c1ccc(N2CCC2)cc1)C1(F)CCN(CCc2ccc(F)cc2F)CC1 CHEMBL176109 Ki 1.0 nM
CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1 CHEMBL212912 Ki 1.0 nM
CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc4ccccc34)c3ccccc32)CC1 CHEMBL213834 Ki 1.0 nM
Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1 CHEMBL605405 pKi 1.0 nM
COc1ccc(NC(=O)Nc2ccccc2F)cc1-c1c(Br)cnn1C CHEMBL601097 pKi 1.0 nM
COc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1ccnn1C CHEMBL605001 pIC50 1.0 nM
COc1ccc(NC(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1-c1c(Cl)cnn1C CHEMBL596753 pKi 1.0 nM
O=C(CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCC3)c1ccc(F)cc1 CHEMBL3233427 Ki 1.0 nM
Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(Cl)cc12 CHEMBL3290017 Ki 1.0 nM
Cn1ncc(Cl)c1-c1cc(NC(=O)c2ccc(F)c(C(F)(F)F)c2)ccc1OCCN CHEMBL3652594 IC50 1.0 nM
Fc1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1 CHEMBL4782005 Ki 1.0 nM
CC(C)n1nc2c(c1-c1ccc(Cl)cc1)CCNCC2 CHEMBL4784845 Ki 1.0 nM
Cc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1 CHEMBL4746737 Ki 1.0 nM
Cc1cccc(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)c1 CHEMBL4779739 pKi 1.023 nM
CC1Cc2cccc(CCN3CCN(c4nsc5ccccc45)CC3)c2NC1=O CHEMBL197614 Ki 1.06 nM
COc1cccc(CC(=O)N2CCC(C)c3cccc(CCN4CCN(c5nsc6ccccc56)CC4)c32)c1 CHEMBL199161 Ki 1.07 nM
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5ccccc45)CC3)c(F)c21 CHEMBL1258084 Ki 1.08 nM
Cc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1 CHEMBL605081 pKi 1.096 nM
O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(F)cc2s1 CHEMBL4762226 pKi 1.096 nM
O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1csc2ccccc12 CHEMBL4782149 pKi 1.096 nM
O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc2ccccc12 CHEMBL4776225 pKi 1.096 nM
CN1[C@@H]2CC[C@H]1C[C@H](N1CCC(c3c(-c4ccccc4)[nH]c4ccccc34)CC1)C2 CHEMBL3084807 Ki 1.1 nM
CN1CCN(C2=Cn3cccc3Sc3ccccc32)CC1 CHEMBL367045 Ki 1.1 nM
CCC1(NC2=NCCNC(c3ccc(F)cc3F)=C2)CCCC1 CHEMBL373966 IC50 1.1 nM
Cn1cc(Br)c(C(=O)N2CCN(CCc3ccc(F)cc3F)CC2)n1 CHEMBL1214659 Ki 1.1 nM
CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc21 CHEMBL71 Ki 1.1 nM
O=C(CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCCC3)c1ccc(F)cc1 CHEMBL3233430 Ki 1.1 nM
O=C(CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1ccc(F)cc1 CHEMBL267930 Ki 1.1 nM
CCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1 CHEMBL3902496 Ki 1.1 nM
O=C1C2CCCC2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1 CHEMBL4291387 IC50 1.1 nM
COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC CHEMBL1729 Ki 1.102 nM
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5cccc(F)c45)CC3)c(Cl)c21 CHEMBL1257147 Ki 1.13 nM
CN(C)CC1CC2c3ccccc3Cc3ccc(F)cc3N2O1 CHEMBL84931 pIC50 1.148 nM
O=[N+]([O-])c1ccc(C(O)C2CCN(CCc3ccccc3)CC2)cc1 CHEMBL74317 Ki 1.15 nM
O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2[nH]c3ccccc3c21 CHEMBL333174 Log Ki 1.175 nM
CNCc1ccc(Cl)cc1Oc1ccc(C)cc1 CHEMBL447864 IC50 1.18 nM
O=C1NCc2cc(F)c(OCCCN3CCN(c4cccc5cccc(F)c45)CC3)cc21 CHEMBL1258535 Ki 1.19 nM
Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2 CHEMBL4083333 IC50 1.19 nM
CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1 CHEMBL42 Ki 1.199 nM
Nc1cc(F)ccc1C(=O)CCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CCC3 CHEMBL163904 Ki 1.2 nM
O=S(=O)(c1ccccc1)C1CCN(CCc2ccccc2)CC1 CHEMBL148280 Ki 1.2 nM
c1ccc(CCN2C3CCC2CC(N2CCC(c4c(-c5ccccc5)[nH]c5ccccc45)CC2)C3)cc1 CHEMBL330482 Ki 1.2 nM
c1ccc(CCN2[C@@H]3CC[C@H]2CC(c2c(-c4ccccc4)[nH]c4ccccc24)C3)cc1 CHEMBL2113667 Ki 1.2 nM
CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1 CHEMBL198463 Ki 1.2 nM
CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(F)cccc3C(F)(F)F)c3ccccc32)CC1 CHEMBL213492 Ki 1.2 nM
O=C(CCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 CHEMBL297302 Ki 1.2 nM
CN([C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1)S(=O)(=O)c1cccs1 CHEMBL3895540 Ki 1.2 nM
Cn1ncc(Cl)c1-c1cc(NC(=O)C(=O)c2cc(Br)cs2)ccc1OCCN CHEMBL3652596 IC50 1.2 nM
Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1 CHEMBL592752 Ki 1.2 nM
O=C(CCCN1CCCN(c2ccccn2)CC1)c1ccc(F)cc1 CHEMBL4533305 Ki 1.2 nM
COc1cccc(OC)c1CC(=O)N1CCC(C)c2cccc(CCN3CCN(c4nsc5ccccc45)CC3)c21 CHEMBL262469 Ki 1.24 nM
CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2 CHEMBL479 Ki 1.247 nM
COc1ccc(NC(=O)Nc2ccc(F)c(F)c2)cc1-c1c(F)cnn1C CHEMBL597983 pKi 1.259 nM
c1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1 CHEMBL4213379 pKi 1.259 nM
Cc1c(OCCCCN2CCN(c3cccc4ccccc34)CC2)ccc2c1C(=O)NC2 CHEMBL1257495 Ki 1.26 nM
Cn1ccc2c(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)cccc21 CHEMBL4749824 pKi 1.288 nM
NCC1c2ccccc2Cc2cc(Br)ccc21 CHEMBL85882 Ki 1.3 nM
O=C1CCc2ccc(OCCCCN3CCN(c4cccc5c4CCCO5)CC3)nc2N1 CHEMBL1774078 Ki 1.3 nM
C[C@H]1CNCCc2ccc(Cl)cc21 CHEMBL360328 Ki 1.3 nM
O=C(CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCS3)c1ccc(F)cc1 CHEMBL3233431 Ki 1.3 nM
Cc1cccc(S(=O)(=O)NCCCN2CCN(c3nsc4ccccc34)CC2)c1 CHEMBL3289709 Ki 1.3 nM
O=S(=O)(c1ccccc1)c1ccc(/C=C/c2ccc(F)cc2F)cc1 CHEMBL1082773 Ki 1.32 nM
COc1cc(CCNCc2cccc(O)c2)c(OC)cc1Br CHEMBL3589598 pKi 1.349 nM
N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O CHEMBL350221 pEC50 1.349 nM
Cc1ccc2sc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)cc2c1 CHEMBL4784414 pKi 1.349 nM
O=S(=O)(c1ccc(Cl)cc1)C1CCN(CCc2ccc(F)cc2F)CC1 CHEMBL149429 Ki 1.4 nM
CC(C)(NC1=NCCNC(c2ccc(F)cc2F)=C1)C1CCC1 CHEMBL436513 IC50 1.4 nM
Cn1nccc1-c1cc(NC(=O)Nc2ccccc2)ccc1OCCN1CCCCC1 CHEMBL565525 Ki 1.4 nM
Cc1ccc(NC(=O)Nc2ccc(OCCN3CCCCC3)c(-c3ccnn3C)c2)cc1 CHEMBL585899 Ki 1.4 nM
O=C1CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4C(F)(F)F)CC3)nc2N1 CHEMBL1774075 Ki 1.4 nM
Nc1cccc2nc(C(=O)N3CCN(CCc4ccc(F)cc4F)CC3)cn12 CHEMBL1957812 Ki 1.4 nM
O=C(CO)N[C@H]1CC[C@H](CCN2CCN(c3nccc4sccc34)CC2)CC1 CHEMBL3642704 Ki 1.4 nM
O=S(=O)(c1ccccc1)c1ccc(CCc2ccc(F)cc2F)cc1 CHEMBL1083415 Ki 1.43 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)ccc34)CC2)CC1)C1(O)CC1 CHEMBL3981112 Ki 1.444 nM
OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1 CHEMBL726 Ki 1.458 nM
COc1ccc2c(c1)CC(CN1CCC(c3noc4cc(F)ccc34)CC1)CC2=O CHEMBL421801 Log Ki 1.479 nM
Nc1cc(F)ccc1C(=O)CCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CCS3 CHEMBL351247 Ki 1.5 nM
CCC(C)(CC)NC1=NCCNC(c2ccc(F)cc2)=C1 CHEMBL219265 IC50 1.5 nM
Cc1c(Cl)cccc1N1CCN(CCCCOc2ccc3c(n2)NC(=O)CC3)CC1 CHEMBL1774072 Ki 1.5 nM
O=C(c1cccn2cc(Cl)nc12)N1CCN(CCc2ccc(F)cc2F)CC1 CHEMBL1957818 Ki 1.5 nM
O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1 CHEMBL3289954 Ki 1.5 nM
O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(F)c(Cl)c1 CHEMBL3289995 Ki 1.5 nM
Cc1ccc2c(c1)N=C(C1=CCN(C)CC1)c1cc(F)ccc1N2 CHEMBL4873426 INH 1.5 nM
Oc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1 CHEMBL5200026 EC50 1.5 nM
O=C(c1ccc(F)cc1)C1CCN(CCn2c(=S)[nH]c3ccccc3c2=O)CC1 CHEMBL2355519 IC50 1.51 nM
C[C@H]1C[C@H](NS(=O)(=O)c2ccc3ccccc3c2)CN1CCCc1noc2cc(F)ccc12 CHEMBL5088232 pKi 1.514 nM
COC(=O)c1coc2c1C(=O)CC(CN1CCC(c3noc4cc(F)ccc34)CC1)C2 CHEMBL461627 pKi 1.549 nM
O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc(Cl)c1 CHEMBL4741142 pKi 1.549 nM
CC(C)Nc1cc2c(cc1NS(=O)(=O)c1ccc(-c3ccc(Cl)cc3)cc1)CCN(C)CC2 CHEMBL231350 Log Ki 1.585 nM
COc1ccc(NC(=O)Nc2ccc(N(C)C)cc2)cc1-c1c(Br)cnn1C CHEMBL596975 pKi 1.585 nM
CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 CHEMBL485253 pKi 1.585 nM
c1ccc(Cc2cccc3c2CCC2CNCCN32)cc1 CHEMBL3919795 pKi 1.585 nM
c1cc(Cc2ccc3c(c2)OCO3)c2c(c1)N1CCNCC1CC2 CHEMBL3935339 pKi 1.585 nM
Nc1ccccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCO3 CHEMBL351708 Ki 1.6 nM
CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1 CHEMBL366164 Ki 1.6 nM
CC1(NC2=NCCNC(c3ccc(F)cc3)=C2)CCCCC1 CHEMBL219215 IC50 1.6 nM
O=c1ccc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nc2[nH]1 CHEMBL1774064 Ki 1.6 nM
O=C(c1cccn2ccnc12)N1CCN(CCc2ccc(F)cc2F)CC1 CHEMBL1957816 Ki 1.6 nM
O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1csc2ccccc12 CHEMBL3290009 Ki 1.6 nM
O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2ccccc21 CHEMBL308480 Ki 1.6 nM
COc1cc(C(=O)N[C@H]2CC[C@H](CCN3CCC(c4noc5cc(F)ccc45)CC3)CC2)ccn1 CHEMBL3891803 Ki 1.623 nM
OC(c1ccc(F)cc1)C1CCN(CCc2ccc(F)cc2)CC1 CHEMBL420010 Ki 1.63 nM
O=C1COc2ccccc2N1CCCCN1CCN(c2cccc3sccc23)CC1 CHEMBL4741908 IC50 1.64 nM
O=C(NC1CCc2cc(CCN3CCN(c4nsc5ccccc45)CC3)ccc21)c1ccc(F)cc1 CHEMBL252429 Ki 1.65 nM
CCS(=O)(=O)N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)ccc34)CC2)CC1 CHEMBL3914062 Ki 1.664 nM
O=C1c2ccccc2CCCN1CCN1CCC(c2c[nH]c3ccccc23)CC1 CHEMBL267062 Log Ki 1.698 nM
COc1cc(CCNCc2cccc3ccsc23)c(OC)cc1Br CHEMBL3589580 pKi 1.698 nM
Cc1ccc(S(=O)(=O)CC2CCN(CCCc3noc4cc(F)ccc34)C2)cc1C CHEMBL5092755 pKi 1.698 nM
O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc(Cl)c(Cl)c1 CHEMBL5077755 pKi 1.698 nM
COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC CHEMBL5207529 pEC50 1.698 nM
CCN(C)CCc1c(-c2cccs2)[nH]c2ccccc12 CHEMBL92416 Ki 1.7 nM
O=S(=O)(c1ccccc1-c1cccc2ccccc12)N1CCC(CCc2ccc(F)cc2F)CC1 CHEMBL206308 Ki 1.7 nM
O=C(c1cccn2cc(Br)nc12)N1CCN(CCc2ccc(F)cc2F)CC1 CHEMBL1957817 Ki 1.7 nM
O=C(c1cnc2ccccn12)N1CCN(CCc2ccc(F)cc2F)CC1 CHEMBL1957814 Ki 1.7 nM
CN1CCN2c3c(cccc31)[C@@H]1CCN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12 CHEMBL3233423 Ki 1.7 nM
O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12 CHEMBL3290002 Ki 1.7 nM
O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1 CHEMBL3290006 Ki 1.7 nM
COc1c(Cl)cccc1N1CCN(CCCCNC(=O)c2cnc3ccccc3c2)CC1 CHEMBL3597637 Ki 1.7 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nccc4sccc34)CC2)CC1)C1CCOCC1 CHEMBL3642702 Ki 1.7 nM
CC(=O)c1c(C)cc2oc(=O)cc(C)c2c1OCCCCN1CCN(c2ccc(Cl)cc2)CC1 CHEMBL4284002 Ki 1.7 nM
COc1c(Br)cc([18F])cc1CCNCc1cccc2c1OCO2 CHEMBL5181183 Ki 1.7 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)ccc34)CC2)CC1)c1ccc2c(c1)OCO2 CHEMBL3986005 Ki 1.714 nM
CC(C)(C)Oc1ccc(C(=O)N[C@H]2CC[C@H](CCN3CCC(c4noc5cc(F)ccc45)CC3)CC2)cc1 CHEMBL3973600 Ki 1.724 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)ccc34)CC2)CC1)C1CCOCC1 CHEMBL3970010 Ki 1.739 nM
c1ccc2c(N3CCN(CCCOc4ccc5c(c4)CNC5)CC3)cccc2c1 CHEMBL1258312 Ki 1.76 nM
COc1ccc2[nH]cc(CCN(C)C)c2c1 CHEMBL7257 EC50 1.76 nM
CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]c(Br)c(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 CHEMBL493 pEC50 1.778 nM
COc1ccc2c(c1)CCC1(CCN(CCc3ccc(F)cc3F)CC1)O2 CHEMBL146233 Ki 1.8 nM
c1ccc(-c2[nH]c3ccccc3c2C2CC3CCC(C2)N3)cc1 CHEMBL501295 Ki 1.8 nM
O=C(N[C@H]1CCN(Cc2ccccc2)C1)c1ccc(-c2cccs2)cc1 CHEMBL360424 Ki 1.8 nM
Cc1c(O)ccc2cnn(C[C@H](C)N)c12 CHEMBL200104 Ki 1.8 nM
O=S(=O)(c1ccc(/C=C/c2ccc(F)cc2Cl)nc1)c1ccccc1F CHEMBL397112 Ki 1.8 nM
COc1cccc(C(=O)Nc2ccc(OCCNCCO)c(-c3ccnn3C)c2)c1 CHEMBL1082474 Ki 1.8 nM
O=C(c1cnn2ccccc12)N1CCN(CCc2ccc(F)cc2F)CC1 CHEMBL1957803 Ki 1.8 nM
O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1 CHEMBL3290004 Ki 1.8 nM
CN(C)CCN(Cc1ccccc1)S(=O)(=O)c1ccc(I)cc1 CHEMBL3753894 Ki 1.8 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nsc4cc([N+](=O)[O-])ccc34)CC2)CC1)c1ccco1 CHEMBL3970746 Ki 1.8 nM
COCCC(=O)N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)ccc34)CC2)CC1 CHEMBL3940461 Ki 1.809 nM
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5cccc(F)c45)CC3)cc21 CHEMBL1258879 Ki 1.83 nM
CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C=C2c3cccc4[nH]cc(c34)C[C@H]21 CHEMBL442 Ki 1.853 nM
C[C@@H]1CNC[C@H]2Cc3ccccc3N21 CHEMBL2112055 Ki 1.9 nM
COc1cc(C[C@H](C)N)c(OC)cc1Br CHEMBL468880 Ki 1.9 nM
Cn1ncc(Br)c1-c1cc(NC(=O)Nc2ccc(O)cc2)ccc1OCCN1CCCC1 CHEMBL568109 Ki 1.9 nM
Cn1nccc1-c1cc(NC(=O)c2ccc(C(F)(F)F)cc2)ccc1OCCN1CCCC1 CHEMBL1084895 Ki 1.9 nM
O=C1CCc2ccc(OCCCCN3CCN(c4cc(F)cc5ccccc45)CC3)nc2N1 CHEMBL1774082 Ki 1.9 nM
O=C(c1nc2ccccn2c1Br)N1CCN(CCc2ccc(F)cc2F)CC1 CHEMBL1957811 Ki 1.9 nM
COc1cc(CCNCc2ccccc2O)c(OC)cc1C#N CHEMBL5184791 EC50 1.9 nM
CN(C)CC1CC2c3ccccc3Oc3ccc(Cl)cc3N2O1 CHEMBL310183 pIC50 1.905 nM
Nc1nc(-c2ccc(F)cc2)c([C@@H]2CCN(CCCC(=O)c3ccc(F)cc3)C2)s1 CHEMBL514848 Ki 1.92 nM
NCCCCNC(=O)COc1ccc(CCCn2ncc3c2nc(N)n2nc(-c4ccco4)nc32)cc1 CHEMBL4294350 Ki 1.92 nM
CN1CCC(N(Cc2ccc(F)cc2)C(=O)NCc2ccc(OCC(O)CN3CCN(C(=O)OC(C)(C)C)CC3)cc2)CC1 CHEMBL4638548 IC50 1.93 nM
COc1cc(CCNCc2ccccc2OC)c(OC)cc1C#N CHEMBL5170895 EC50 1.93 nM
CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCCCF)cc2)CC1 CHEMBL5173703 IC50 1.93 nM
O=C(c1ccc(F)cc1)C1CCN(CCc2ccccc2I)CC1 CHEMBL74756 Ki 1.95 nM
Fc1ccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)cc1 CHEMBL2393247 IC50 1.95 nM
O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc(C(F)(F)F)cc1 CHEMBL5089348 pKi 1.95 nM
CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCCCC(F)(F)F)cc2)CC1 CHEMBL5189473 IC50 1.95 nM
CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 CHEMBL3217984 pKi 1.995 nM
CSc1ccc2c(c1)C(N1CCN(C)CC1)Cc1ccccc1S2 CHEMBL93240 pKi 1.995 nM
C[C@H](N)Cc1c[nH]c2ccc3c(c12)CCCO3 CHEMBL133455 Ki 2.0 nM
O=S(=O)(c1ccc(-n2cccn2)cc1)C1(F)CCN(CCc2ccc(F)cc2F)CC1 CHEMBL178055 Ki 2.0 nM
O=C1Cc2c(ccc3c2OC[C@H](CNCC2CCc4[nH]c5ccc(F)cc5c4C2)O3)N1 CHEMBL569251 Ki 2.0 nM
CC(N)Cc1c[nH]c2ccc(O)cc12 CHEMBL275854 EC50 2.0 nM
O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1 CHEMBL4246655 Kb 2.0 nM
O=C1[C@@H]2[C@H]3CC[C@H](C3)[C@@H]2C(=O)N1C[C@@H]1CCCC[C@H]1CN1CCN(c2nsc3ccccc23)CC1 CHEMBL1237021 Ki 2.0 nM
CC(C)n1nc2c(c1-c1ccc(C(F)(F)F)cc1)CCNCC2 CHEMBL4791646 Ki 2.0 nM
O=C1C2C3CCC(C3)C2C(=O)N1CC1CCCCC1CN1CCN(c2nsc3ccccc23)CC1 CHEMBL5219924 Ki 2.0 nM
CN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 CHEMBL728 Ki 2.018 nM
O=C(CC1COCCO1)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676853 Ki 2.04 nM
CC(C)OCc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1 CHEMBL5200074 IC50 2.05 nM
O=C1NCc2ccc(OCCCN3CCN(c4cccc5ccccc45)CC3)c(Cl)c21 CHEMBL1258882 Ki 2.06 nM
O=C(Cc1ccc2c(c1)OCO2)N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)ccc34)CC2)CC1 CHEMBL3905072 Ki 2.087 nM
O=S(=O)(c1ccccc1-c1cccc2cccnc12)N1CCC(CCc2ccc(F)cc2F)CC1 CHEMBL380682 Ki 2.1 nM
CN1CCN(CCOc2ccc(NC(=O)Nc3ccc(Cl)cc3)cc2-c2ccnn2C)CC1 CHEMBL568108 Ki 2.1 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(OCCN3CCCCC3)c(-c3ccnn3C)c2)c1 CHEMBL569485 Ki 2.1 nM
O=S(=O)(c1cccc2cccnc12)N1CCC(CCc2ccc(F)cc2F)CC1 CHEMBL1082452 Ki 2.1 nM
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5ccc(F)cc45)CC3)c(F)c21 CHEMBL1258313 Ki 2.1 nM
CCN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12 CHEMBL3233144 Ki 2.1 nM
Cc1cccc(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1 CHEMBL3289992 Ki 2.1 nM
COc1ccc(C(=O)N(Cc2ccc(C)cc2)C2CCN(C)CC2)cc1 CHEMBL5181814 Ki 2.1 nM
CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCCF)cc2)CC1 CHEMBL5178732 IC50 2.11 nM
O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2[nH]ncc21 CHEMBL246484 Log Ki 2.138 nM
Cc1ccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cc1NC(=O)c1ccc(-c2ccccc2)cc1 CHEMBL458002 pKi 2.138 nM
CC(=O)N1CCC(c2ccccc2)c2cccc(CCN3CCN(c4nsc5ccccc45)CC3)c21 CHEMBL439680 Ki 2.15 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1)c1ccc(C2CC2)cc1 CHEMBL3676929 Ki 2.15 nM
N[C@@H](Cc1ccc(OCC(O)CN2CCC(c3noc4cc(F)ccc34)CC2)cc1)C(=O)O CHEMBL5409782 IC50 2.15 nM
CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(F)F)cc2)CC1 CHEMBL5172822 IC50 2.17 nM
COc1ccc2[nH]cc(C(C)CN)c2c1 CHEMBL149564 Ki 2.2 nM
Cc1cccc(C)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21 CHEMBL213336 Ki 2.2 nM
Fc1ccc(-c2nc(C3CCCC3)nc3c2CNCC3)cc1 CHEMBL271212 Ki 2.2 nM
[3H]C([3H])(N1CCC(C(=O)c2ccc(F)cc2)CC1)C([3H])([3H])n1c(=O)[nH]c2ccccc2c1=O CHEMBL1628637 Kd 2.2 nM
CC(=O)N1CCN(CCOc2ccc(NC(=O)c3cccc(F)c3)cc2-c2c(Cl)cnn2C)CC1 CHEMBL1085628 Ki 2.2 nM
COc1cccc(C(=O)Nc2ccc(OCCN)c(-c3ccnn3C)c2)c1 CHEMBL1082795 Ki 2.2 nM
O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1 CHEMBL3289949 Ki 2.2 nM
O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(Cl)c(Cl)c1 CHEMBL3289993 Ki 2.2 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3cccc4occc34)CC2)CC1)C1CCOCC1 CHEMBL3695356 Ki 2.2 nM
COCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3nccc4sccc34)CC2)CC1 CHEMBL3642700 Ki 2.2 nM
O=C(c1ccco1)N1CCC(CCN2CCN(c3nsc4ccccc34)CC2)CC1 CHEMBL3942236 Ki 2.2 nM
O=C1NCc2ccc(OCCCN3CCN(c4cccc5ccccc45)CC3)c(F)c21 CHEMBL1257969 Ki 2.21 nM
CC(=O)N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)ccc34)CC2)CC1 CHEMBL3931423 Ki 2.224 nM
CC1CC(=O)Nc2c(CCN3CCN(c4n[s+]([O-])c5ccccc45)CC3)cc(F)cc21 CHEMBL425208 Ki 2.23 nM
CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCCC(F)(F)F)cc2)CC1 CHEMBL5184906 IC50 2.23 nM
CC(C)(O)C(=O)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676861 Ki 2.25 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)ccc34)CC2)CC1)C1(C(F)(F)F)CCC1 CHEMBL3953154 Ki 2.257 nM
CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21 CHEMBL1732 Ki 2.273 nM
F[C@@H]1CCNC[C@H]1c1c(-c2ccccc2)[nH]c2cc(Cl)ccc12 CHEMBL498048 Ki 2.3 nM
Cc1c(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12 CHEMBL3290015 Ki 2.3 nM
O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1 CHEMBL4239823 Kb 2.3 nM
CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCCCCF)cc2)CC1 CHEMBL5198741 IC50 2.35 nM
CNc1ncc2c(n1)CC(CN1CCC(c3noc4cc(F)ccc34)CC1)CC2=O CHEMBL576756 pKi 2.399 nM
Fc1ccc(CCN2CCC3(CCc4ccccc4O3)CC2)c(F)c1 CHEMBL147431 Ki 2.4 nM
O=C(CN1CCC(S(=O)(=O)c2ccccc2)CC1)c1ccc(F)cc1 CHEMBL146620 Ki 2.4 nM
O=C(CN1CCC(S(=O)(=O)c2ccccc2)CC1)c1ccc(F)cc1F CHEMBL177807 Ki 2.4 nM
Cc1ccc(C2=CC(NC(C)(C)Cc3ccccc3)=NCCN2)cc1 CHEMBL218589 IC50 2.4 nM
Cn1nccc1-c1cc(NC(=O)c2ccc(C(F)(F)F)cc2)ccc1OCCN1CCOCC1 CHEMBL1086316 Ki 2.4 nM
CN1CCN2c3c(cccc31)[C@@H]1CN(CCCOc3ccc(F)cc3)CC[C@@H]12 CHEMBL3233409 Ki 2.4 nM
O=C(NCCC(O)CN1CCN(c2cccc3ccccc23)CC1)c1cnc2ccccc2c1 CHEMBL3597636 Ki 2.4 nM
CCc1cc(OC)cc(CCNCc2cccc(F)c2)c1OC CHEMBL5169584 Ki 2.4 nM
CNCCc1c[nH]c2cccc(O)c12 CHEMBL4648350 EC50 2.4 nM
CCc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1Cl CHEMBL4476699 Ki 2.41 nM
CN1CCN(C2=Nc3ccccc3Oc3ccc(Cl)cc32)CC1 CHEMBL831 Ki 2.42 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1)C1CCOCC1 CHEMBL3676848 Ki 2.44 nM
O=C(NC1CCc2ccc(CCN3CCN(c4nsc5ccccc45)CC3)cc21)c1ccc(F)cc1 CHEMBL442290 Ki 2.45 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)ccc34)CC2)CC1)c1ccc(-n2cccc2)cc1 CHEMBL3965582 Ki 2.45 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)ccc34)CC2)CC1)c1cnc(N2CCOCC2)nc1 CHEMBL3982578 Ki 2.453 nM
OC(c1ccccc1)C1CCN(CCc2ccccc2)CC1 CHEMBL18972 pKi 2.455 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)ccc34)CC2)CC1)c1ccnc(N2CCOCC2)c1 CHEMBL3966657 Ki 2.459 nM
O=S(=O)(N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)ccc34)CC2)CC1)c1cccnc1 CHEMBL3897422 Ki 2.476 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)ccc34)CC2)CC1)c1ccc(N2CCS(=O)(=O)CC2)cc1 CHEMBL3980954 Ki 2.483 nM
CO[C@@H]1[C@@H](OC)[C@H](C)[C@@](O)(CC(=O)O)O[C@H]1[C@H](C)[C@H]1O[C@@]2(CC[C@@](C)([C@H]3CC[C@@](C)([C@@H]4O[C@@H]([C@H]5O[C@](C)(O)[C@H](C)C[C@@H]5C)C[C@@H]4O[C@@H]4C[C@H](OC)[C@@H](OC)[C@H](C)O4)O3)O2)C[C@H](O)[C@H]1C CHEMBL1909065 Ki 2.484 nM
O=C(CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCCS3)c1ccc(F)cc1 CHEMBL352648 Ki 2.5 nM
CN(C)C[C@@H]1C[C@@H]2c3ccccc3Cc3ccccc3N2O1 CHEMBL328573 Ki 2.5 nM
CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1 CHEMBL329566 Ki 2.5 nM
Cc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1 CHEMBL272082 Ki 2.5 nM
CCCCCCc1cc(OC)c(CC(C)N)cc1OC CHEMBL268890 Ki 2.5 nM
Cn1nccc1-c1cc(NC(=O)Nc2ccccc2Cl)ccc1OCCN1CCCCC1 CHEMBL579234 Ki 2.5 nM
CN1CCN2c3c(cccc31)[C@@H]1CN(CCCc3noc4cc(F)ccc34)CC[C@@H]12 CHEMBL3233412 Ki 2.5 nM
CCCc1c(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nnn1Cc1ccccc1 CHEMBL425285 Ki 2.5 nM
CO[C@H]1CC[C@H](CC(=O)N[C@H]2CC[C@H](CCN3CCN(c4nccc5sccc45)CC3)CC2)CC1 CHEMBL3642698 Ki 2.5 nM
CCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1 CHEMBL4873623 Kb 2.5 nM
O=C1C[C@@H](CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2occc21 CHEMBL492689 pKi 2.512 nM
COc1ccc(NC(=O)Nc2cccc(C(C)=O)c2)cc1-c1c(Br)cnn1C CHEMBL599429 pKi 2.512 nM
c1ccc(Cc2cncc3c2CC[C@@H]2CNCCN32)cc1 CHEMBL4778570 pKi 2.512 nM
CCc1ccc(C(=O)N[C@H]2CC[C@H](CCN3CCC(c4coc5ccccc45)CC3)CC2)cc1 CHEMBL3676926 Ki 2.53 nM
CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc3c(c2)CC(C)(C)O3)CC1 CHEMBL5197899 IC50 2.54 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)ccc34)CC2)CC1)C1COc2ccccc2O1 CHEMBL3937872 Ki 2.57 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)ccc34)CC2)CC1)c1ccc(N2CCCCC2)cc1 CHEMBL3909939 Ki 2.598 nM
N#Cc1ccc(S(=O)(=O)C2CCN(CCc3ccc(F)cc3F)CC2)cc1 CHEMBL150220 Ki 2.6 nM
CCN(C)CCc1c(-c2ccc(C#N)cc2)[nH]c2ccccc12 CHEMBL91542 Ki 2.6 nM
c1ccc(-c2[nH]c3ccccc3c2CCN2CCCCC2)cc1 CHEMBL91205 Ki 2.6 nM
Cc1c(Cl)ccc2c1N1[C@@H](CNC[C@H]1C)C2 CHEMBL190699 Ki 2.6 nM
O=S(=O)(c1ccc(/C=C/c2ccc(F)cc2F)nc1)c1ccccc1F CHEMBL240865 Ki 2.6 nM
O=S(=O)(c1ccc(/C=C/c2ccccc2F)nc1)c1ccccc1F CHEMBL240665 Ki 2.6 nM
CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1 CHEMBL263881 Ki 2.6 nM
O=S(=O)(c1cccc2ccccc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1 CHEMBL602882 IC50 2.6 nM
CCn1cc(Cl)c(C(=O)N2CCN(CC(=O)c3ccc(F)cc3)CC2)n1 CHEMBL1214947 Ki 2.6 nM
O=C(c1cc2n(n1)CCCC2)N1CCN(CCc2ccc(F)cc2F)CC1 CHEMBL1957808 Ki 2.6 nM
O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccc(Cl)cc2s1 CHEMBL3290013 Ki 2.6 nM
CCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3nccc4sccc34)CC2)CC1 CHEMBL3642696 Ki 2.6 nM
CC(C)c1ccc(C(=O)N[C@H]2CC[C@H](CCN3CCC(c4coc5ccccc45)CC3)CC2)cc1 CHEMBL3676928 Ki 2.6 nM
O=C(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)Nc1ccn2ncc(/C=N\O)c2c1 CHEMBL4069091 Ki 2.6 nM
Cc1nc2c(c(=O)n1CCN1CCC(C(=O)c3ccc(F)cc3)CC1)CCCC2 CHEMBL5267849 pKi 2.63 nM
N#Cc1c[nH]c2c(C(=O)N3CCN(CCc4ccc(F)cc4)CC3)cccc12 CHEMBL2104980 Ki 2.638 nM
NCCc1c[nH]c2ccc(F)cc12 CHEMBL275628 EC50 2.64 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)ccc34)CC2)CC1)c1ccc(Cl)cc1 CHEMBL3952117 Ki 2.666 nM
O=C1NCc2cc(F)c(OCCCN3CCN(c4cccc5ccc(F)cc45)CC3)cc21 CHEMBL1258650 Ki 2.68 nM
c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1 CHEMBL2393243 IC50 2.69 nM
CC(C)Cc1ccc(C(=O)N[C@H]2CC[C@H](CCN3CCC(c4coc5ccccc45)CC3)CC2)cc1 CHEMBL3676925 Ki 2.69 nM
O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2ccccc21 CHEMBL155486 Log Ki 2.692 nM
O=C1COc2ccccc2N1CCCN1CCC(c2noc3cc(F)ccc23)CC1 CHEMBL4062602 pKi 2.692 nM
NC[C@H]1C[C@]1(F)c1cccc(F)c1 CHEMBL4466591 pEC50 2.692 nM
O=C(CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCCS3)c1ccccc1 CHEMBL350567 Ki 2.7 nM
N#Cc1ccc(S(=O)(=O)C2(F)CCN(CCc3ccc(F)cc3F)CC2)cc1 CHEMBL368816 Ki 2.7 nM
Nc1cccn2cc(C(=O)N3CCN(CCc4ccc(F)cc4F)CC3)nc12 CHEMBL1957813 Ki 2.7 nM
COc1cc(Br)c(OC)c(CCNCc2cccc(F)c2)c1 CHEMBL5191571 Ki 2.7 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)ccc34)CC2)CC1)c1ccc(N2CCOCC2)nc1 CHEMBL3966201 Ki 2.701 nM
C[C@H]1C[C@H](NS(=O)(=O)c2cc3ccccc3o2)CN1CCCc1noc2cc(F)ccc12 CHEMBL5080719 pKi 2.754 nM
O=C(CC(F)(F)F)N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)ccc34)CC2)CC1 CHEMBL3910842 Ki 2.782 nM
Cc1ccn(CC(=O)N[C@H]2CC[C@H](CCN3CCC(c4noc5cc(F)ccc45)CC3)CC2)n1 CHEMBL3915293 Ki 2.795 nM
Nc1cc(F)ccc1C(=O)CCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CCO3 CHEMBL349057 Ki 2.8 nM
CCN(CC)CCc1c(-c2ccccc2)[nH]c2ccccc12 CHEMBL328257 Ki 2.8 nM
N#Cc1cn2cccc(C(=O)N3CCN(CCc4ccc(F)cc4F)CC3)c2n1 CHEMBL1957819 Ki 2.8 nM
C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 CHEMBL2391541 EC50 2.8 nM
O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1 CHEMBL3290005 Ki 2.8 nM
Fc1ccc2[nH]nc(C3=CCCNC3)c2c1 CHEMBL5399727 EC50 2.8 nM
Cc1c(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(Cl)cc12 CHEMBL4780470 pKi 2.818 nM
Nc1ccc2c(c1)N(CCCCN1CCN(c3cccc4sccc34)CC1)S(=O)(=O)CC2 CHEMBL4751542 pIC50 2.818 nM
Cc1nc2n(c(=O)c1CCN1CCN(c3noc4cc(F)ccc34)CC1)CCCC2O CHEMBL4098594 IC50 2.87 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1)C1CCCO1 CHEMBL3676863 Ki 2.88 nM
CNCCc1cc(OC)c(Br)cc1OC CHEMBL57000 Ki 2.9 nM
Fc1ccc(CCN2CCC3(CCc4ccccc4C3)CC2)c(F)c1 CHEMBL150210 Ki 2.9 nM
O=C(c1cccc2cccnc12)N1CCC(CCc2ccc(F)cc2F)CC1 CHEMBL207386 Ki 2.9 nM
Cc1cccc(N)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21 CHEMBL213424 Ki 2.9 nM
O=c1ccc2cnc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2[nH]1 CHEMBL1774065 Ki 2.9 nM
O=C(CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 CHEMBL3233429 Ki 2.9 nM
CCS(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(c3nccc4sccc34)CC2)CC1 CHEMBL3642708 Ki 2.9 nM
CS(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(c3nccc4sccc34)CC2)CC1 CHEMBL3642707 Ki 2.9 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nccc4occc34)CC2)CC1)C1CCOCC1 CHEMBL3642689 Ki 2.9 nM
Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2O CHEMBL4102670 IC50 2.9 nM
COCCOc1cccc(C(=O)C2CCN(CCc3ccc(F)cc3)CC2)c1OC CHEMBL4636980 pKi 2.951 nM
O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1cccc(C(F)(F)F)c1 CHEMBL5082267 pKi 2.951 nM
COc1cc(CC(=O)N[C@H]2CC[C@H](CCN3CCC(c4noc5cc(F)ccc45)CC3)CC2)cc(OC)c1 CHEMBL3946739 Ki 2.953 nM
CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1 CHEMBL1255588 Ki 2.97 nM
CC(N)Cc1c[nH]c2ccc3ccccc3c12 CHEMBL40815 Ki 3.0 nM
CN(C)C[C@@H]1C[C@H]2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1 CHEMBL365101 Ki 3.0 nM
Cc1ccc(C(=O)NC2CCc3ccc(CCN4CCN(c5nsc6ccccc56)CC4)cc32)cc1 CHEMBL398618 Ki 3.0 nM
CN1CCN2c3ccccc3Cc3ccccc3[C@H]2C1 CHEMBL252719 Ki 3.0 nM
Fc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1 CHEMBL1643678 EC50 3.0 nM
Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1 CHEMBL2393245 IC50 3.0 nM
O=C(NCCCCN1CCN(c2cccc3ccccc23)CC1)c1ccccc1 CHEMBL3358512 Ki 3.0 nM
O=C(CC1CCOCC1)N[C@H]1CC[C@H](CCN2CCN(c3nccc4sccc34)CC2)CC1 CHEMBL3642701 Ki 3.0 nM
CNc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1 CHEMBL4789085 Ki 3.0 nM
COc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1 CHEMBL4752099 Ki 3.0 nM
c1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1 CHEMBL4788327 Ki 3.0 nM
COc1cccc2[nH]cc(C3=CCCN(C)C3)c12 CHEMBL5405349 EC50 3.0 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1)C1(O)CC1 CHEMBL3676867 Ki 3.05 nM
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5cc(F)ccc45)CC3)c(F)c21 CHEMBL1258427 Ki 3.07 nM
Cc1ccc2c(c1)N1OC(CN(C)C)CC1c1ccccc1C2 CHEMBL85735 pIC50 3.09 nM
COc1cc(CCNCc2cccc(OC)c2OC)c(OC)cc1Br CHEMBL3589591 pKi 3.09 nM
Nc1ccccc1C(=O)CCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CCCC3 CHEMBL163261 Ki 3.1 nM
Fc1ccc(CCN2CCC3(CCc4ccc(F)cc4O3)CC2)c(F)c1 CHEMBL148348 Ki 3.1 nM
O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2cc(Cl)ccc2c1 CHEMBL3290007 Ki 3.1 nM
CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(C)(C)F)cc2)CC1 CHEMBL5184297 IC50 3.13 nM
O=C1NCc2ccc(OCCCN3CCN(c4cccc5c4CCC5)CC3)cc21 CHEMBL1257262 Ki 3.16 nM
O=c1[nH]c2ccccc2n1C1CCN(CCCOc2ccc(F)cc2)CC1 CHEMBL1802360 pKi 3.162 nM
O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2s1 CHEMBL4795995 pKi 3.162 nM
COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1 CHEMBL5204071 pEC50 3.162 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)ccc34)CC2)CC1)c1ccc(N2CCOCC2)nn1 CHEMBL3954263 Ki 3.181 nM
NCC1c2ccccc2Cc2cc(CCCc3ccccc3)ccc21 CHEMBL83082 Ki 3.2 nM
Cn1nccc1-c1cc(NC(=O)Nc2ccc(F)cc2F)ccc1OCCN1CCCCC1 CHEMBL567458 Ki 3.2 nM
O=c1ccc2cnc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nc2[nH]1 CHEMBL1774066 Ki 3.2 nM
COc1ccc(Cn2nnc(C(=O)NCCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2C)cc1 CHEMBL221866 Ki 3.2 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1)N1CCOCC1 CHEMBL3909821 Ki 3.2 nM
CCc1cccc(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4o3)CC2)c1Cl CHEMBL4517102 Ki 3.2 nM
CCc1cccc(N2CCN(C)CC2)c1Cl CHEMBL4469777 Ki 3.22 nM
Fc1ccc(CCN2CCC3(CCc4cccc(F)c4O3)CC2)c(F)c1 CHEMBL149423 Ki 3.3 nM
O[C@@H]1CCNC[C@H]1c1c(-c2ccccc2)[nH]c2ccccc12 CHEMBL2368748 Ki 3.3 nM
COc1cccc(NC(=O)Nc2ccc(OCCN3CCCCC3)c(-c3ccnn3C)c2)c1 CHEMBL569508 Ki 3.3 nM
O=C1CCc2ccc(OCCCCN3CCN(c4cccc5c(F)cccc45)CC3)nc2N1 CHEMBL1774084 Ki 3.3 nM
CN1CCN2c3c(cccc31)[C@@H]1CN(CCCc3noc4ccccc34)CC[C@@H]12 CHEMBL3233411 Ki 3.3 nM
CC(=O)N[C@H]1CC[C@H](CCN2CCN(c3nccc4sccc34)CC2)CC1 CHEMBL3642693 Ki 3.3 nM
CCOC(=O)N1CCC(CCN2CCN(c3nsc4ccccc34)CC2)CC1 CHEMBL3914241 Ki 3.3 nM
COc1cc(CCNCc2cccc(OC)c2F)c(OC)cc1Br CHEMBL3589595 pKi 3.311 nM
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5c4CCCC5)CC3)cc21 CHEMBL1257614 Ki 3.35 nM
COCC(=O)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676851 Ki 3.36 nM
O=C1NCc2ccc(OCCCN3CCN(c4cccc5ccc(F)cc45)CC3)cc21 CHEMBL1258648 Ki 3.37 nM
Cc1ccc2c(c1)Oc1sc(Cl)cc1C(N1CCN(CC(C)(C)C(=O)O)CC1)=N2 CHEMBL3899169 Ki 3.37 nM
COc1cc(CCNCc2ccc(F)cc2)c(OC)cc1Br CHEMBL58136 Ki 3.4 nM
COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccc(F)cc3)CC2)CC2CCCCC2)cc1 CHEMBL605787 IC50 3.4 nM
O=C(CCCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1 CHEMBL2037531 Ki 3.4 nM
Cc1nc2n(c(=O)c1CCN1CCN(c3nsc4ccccc34)CC1)CCCC2(C)O CHEMBL4061068 IC50 3.4 nM
Clc1ccc2[nH]nc(C3=CCCNC3)c2c1 CHEMBL5416604 EC50 3.4 nM
CNCc1ccc(Cl)cc1Oc1ccc(C)c(C)c1 CHEMBL475121 IC50 3.42 nM
O=C1NCc2ccc(OCCCN3CCN(c4cccc5cccc(F)c45)CC3)c(F)c21 CHEMBL1258085 Ki 3.45 nM
CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1 CHEMBL315772 Log IC50 3.467 nM
O=C1NCc2cc(F)c(OCCCCN3CCN(c4cccc5cccc(F)c45)CC3)cc21 CHEMBL1258649 Ki 3.49 nM
CCN(C)CCc1c(-c2ccc(Cl)cc2)[nH]c2ccccc12 CHEMBL91463 Ki 3.5 nM
[O-][S+](c1ccc(/C=C/c2ccc(F)cc2F)nc1)c1ccccc1F CHEMBL238760 Ki 3.5 nM
NCC(c1ccccc1)c1ccc(Br)cc1 CHEMBL444761 Ki 3.5 nM
O=C1CCc2ccc(OCCCCN3CCN(c4cccc5cc(F)ccc45)CC3)nc2N1 CHEMBL1774085 Ki 3.5 nM
Cc1nc2ccccn2c1C(=O)N1CCN(CCc2ccc(F)cc2F)CC1 CHEMBL1957815 Ki 3.5 nM
COc1cc2c3c(c1)N(C)CCN3[C@H]1CCN(CCCC(=O)c3ccc(F)cc3)C[C@@H]21 CHEMBL3233149 Ki 3.5 nM
Cc1cccc(S(=O)(=O)NCCN2CCC(c3noc4cc(F)ccc34)CC2)c1 CHEMBL3289990 Ki 3.5 nM
COCCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3nccc4sccc34)CC2)CC1 CHEMBL3642697 Ki 3.5 nM
CNC(C)c1ccc(Cl)cc1Oc1ccc(C)cc1 CHEMBL461631 IC50 3.54 nM
O=C1NCc2ccc(OCCCN3CCN(c4cccc5cc(F)ccc45)CC3)cc21 CHEMBL1258880 Ki 3.54 nM
CS(=O)(=O)CC(=O)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676852 Ki 3.54 nM
C[C@H]1C[C@H](NS(=O)(=O)c2ccc(F)c(Cl)c2)CN1CCCc1noc2cc(F)ccc12 CHEMBL5093017 pKi 3.548 nM
O=C1NCc2ccc(OCCCN3CCN(c4cccc5cccc(F)c45)CC3)c(Cl)c21 CHEMBL1257146 Ki 3.55 nM
C[C@@H](N)Cc1c[nH]c2ccc3c(c12)CCCO3 CHEMBL135076 Ki 3.6 nM
CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3 CHEMBL133868 Ki 3.6 nM
CCC1(NC2=NCCNC(c3ccccc3F)=C2)CCCC1 CHEMBL386613 IC50 3.6 nM
O=S(=O)(c1ccc(/C=C/c2ccccc2O)nc1)c1ccccc1F CHEMBL240877 Ki 3.6 nM
Cn1cc(Br)c(C(=O)N2CCN(CCc3ccc(F)cc3)CC2)n1 CHEMBL1215727 Ki 3.6 nM
Cc1cc(C)n2ccnc2c1C(=O)N1CCN(CCc2ccc(F)cc2F)CC1 CHEMBL1957821 Ki 3.6 nM
O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(OC(F)(F)F)cc1 CHEMBL3289998 Ki 3.6 nM
Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1C CHEMBL3358493 Ki 3.6 nM
N[C@@H](Cc1ccc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)cc1)C(=O)O CHEMBL5419552 IC50 3.6 nM
O=C(c1ccc(F)cc1)C1CCN(CCc2ccc(I)cc2)CC1 CHEMBL73979 Ki 3.62 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nccc4c3CCO4)CC2)CC1)c1ccnc2ccccc12 CHEMBL3642739 Ki 3.62 nM
COc1ccc(C(=O)N[C@H]2CC[C@H](CCN3CCC(c4noc5cc(F)ccc45)CC3)CC2)cc1 CHEMBL3906069 Ki 3.654 nM
Nc1ccccc1C(=O)CCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CCC3 CHEMBL352686 Ki 3.7 nM
CCC(CC)(CC)NC1=NCCNC(c2ccc(F)cc2F)=C1 CHEMBL218587 IC50 3.7 nM
Cn1cc(Cl)c(C(=O)N2CCN(CC(=O)c3ccc(F)cc3)CC2)n1 CHEMBL1214946 Ki 3.7 nM
Cc1cccc(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1 CHEMBL3289991 Ki 3.7 nM
CO[C@@H]1CC[C@@H](CC(=O)N[C@H]2CC[C@H](CCN3CCN(c4nccc5sccc45)CC3)CC2)C1 CHEMBL3642699 Ki 3.7 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3cccc4c3OCO4)CC2)CC1)C1(O)CCCC1 CHEMBL3697986 Ki 3.72 nM
CC(C)(C)c1ccc(C(=O)N[C@H]2CC[C@H](CCN3CCC(c4coc5ccccc45)CC3)CC2)cc1 CHEMBL3676905 Ki 3.77 nM
CC(C)(Cc1ccccc1)NC1=NCCNC(c2ccccc2F)=C1 CHEMBL386612 IC50 3.8 nM
O=C(c1cnn2cccnc12)N1CCN(CCc2ccc(F)cc2F)CC1 CHEMBL1957807 Ki 3.8 nM
O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(OC(F)(F)F)cc1 CHEMBL3289997 Ki 3.8 nM
COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(O)cc32)cc1OC CHEMBL5178632 EC50 3.8 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)ccc34)CC2)CC1)c1cnc(N2CCOCC2)cn1 CHEMBL3986708 Ki 3.81 nM
CC[C@@H](CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 CHEMBL1065 Ki 3.832 nM
Cc1c(OCCCCN2CCN(c3cccc4cccc(F)c34)CC2)ccc2c1C(=O)NC2 CHEMBL1257616 Ki 3.85 nM
CN(C)CCCC1CC2c3ccccc3Cc3ccccc3N2O1 CHEMBL310018 pIC50 3.89 nM
O=C(CCCN1CCc2ccccc2C1)c1ccccc1 CHEMBL3818989 pKi 3.89 nM
Cc1c(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(F)cc12 CHEMBL4778418 pKi 3.89 nM
C[C@H]1C[C@H](NS(=O)(=O)c2cccc(Cl)c2)CN1CCCc1noc2cc(F)ccc12 CHEMBL5076882 pKi 3.89 nM
O=C(c1ccccc1F)N1CCC(CCc2ccc(F)cc2F)CC1 CHEMBL210230 Ki 3.9 nM
Cn1cc(Br)c(C(=O)N2CCN(CC(=O)c3ccc(F)cc3)CC2)n1 CHEMBL1214731 Ki 3.9 nM
COc1cccc2[nH]cc(C3=CCCNC3)c12 CHEMBL5440705 EC50 3.9 nM
CCCN1C[C@H](CSC)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21 CHEMBL531 Ki 3.904 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3cccc4c3OCO4)CC2)CC1)C1(O)CCCCC1 CHEMBL3664878 Ki 3.93 nM
Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc5c(c4)N(CCN(C)C)CCO5)cc3)c(C)c2)no1 CHEMBL20791 pKi 3.981 nM
c1ccc2c(c1)Cc1ccccc1C21CCNC1 CHEMBL307956 Ki 4.0 nM
Fc1ccc2[nH]c(-c3ccccc3)c([C@@H]3CNCC[C@H]3F)c2c1 CHEMBL497878 Ki 4.0 nM
C[C@H]1CCCCN1CCc1c(-c2ccccc2)[nH]c2ccccc12 CHEMBL90739 Ki 4.0 nM
CC1SC2(CCCC2)C(=O)N1CCCCN1CCN(c2csc3cc(F)ccc23)CC1 CHEMBL131482 Ki 4.0 nM
CC(C)c1nc2c(c(-c3ccc(F)cc3)n1)CCNCC2 CHEMBL255543 Ki 4.0 nM
Cn1nccc1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCCCN1CCOCC1 CHEMBL572134 Ki 4.0 nM
CN1CCN2c3c(cc(Br)cc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12 CHEMBL3233148 Ki 4.0 nM
O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12 CHEMBL3287403 Ki 4.0 nM
O=C(NCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1cc2ccccc2[nH]1 CHEMBL3358104 Ki 4.0 nM
O=C(C[C@H]1CC[C@H](O)CC1)N[C@H]1CC[C@H](CCN2CCN(c3nccc4sccc34)CC2)CC1 CHEMBL3642705 Ki 4.0 nM
CC(=O)c1c(C)cc2oc(=O)cc(C)c2c1OCCCN1CCN(c2ccc(Cl)cc2)CC1 CHEMBL4295030 Ki 4.0 nM
O=C(c1cccn2ccnc12)N1CCN(CCc2ccccc2Cl)CC1 CHEMBL4449354 IC50 4.0 nM
O=C1[C@@H]2[C@H]3CC[C@H](C3)[C@@H]2C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1 CHEMBL4641609 Ki 4.0 nM
O=C(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccccc1 CHEMBL4645793 Ki 4.0 nM
Clc1ccc2c(c1)N=C(N1CCNCC1)c1ccccc1N2 CHEMBL845 INH 4.0 nM
CNCCc1c[nH]c2ccc(OC)cc12 CHEMBL58579 Ki 4.1 nM
c1cc2c3c(c1)c1c(n3CCO2)CCNCC1 CHEMBL76494 Ki 4.1 nM
Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1-c1ccc(F)cc1 CHEMBL1088314 IC50 4.1 nM
Cn1nccc1-c1cc(NC(=O)c2ccc(F)c(F)c2)ccc1OCCN1CCOCC1 CHEMBL1085615 Ki 4.1 nM
O=C(CC1COCCO1)N[C@H]1CC[C@H](CCN2CCC(c3cccc4occc34)CC2)CC1 CHEMBL3695365 Ki 4.1 nM
NCCc1c[nH]c2ccc(Cl)cc12 CHEMBL1288716 EC50 4.11 nM
O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc(Cl)c1 CHEMBL4784228 pKi 4.169 nM
C[C@H]1C[C@H](NS(=O)(=O)c2csc3ccccc23)CN1CCCc1noc2cc(F)ccc12 CHEMBL5087742 pKi 4.169 nM
C[C@H]1C[C@H](NS(=O)(=O)c2cc3ccc(Cl)cc3s2)CN1CCCc1noc2cc(F)ccc12 CHEMBL5073337 pKi 4.169 nM
Nc1cc(F)ccc1C(=O)CCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CCCS3 CHEMBL349151 Ki 4.2 nM
O=[N+]([O-])c1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1 CHEMBL605582 IC50 4.2 nM
COCC(=O)N[C@H]1CC[C@H](CCN2CCC(c3cccc4occc34)CC2)CC1 CHEMBL3695363 Ki 4.2 nM
CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O CHEMBL1255837 Ki 4.24 nM
CN(C)CCc1c[nH]c2cccc(O)c12 CHEMBL65547 pEC50 4.266 nM
Cc1cccc(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)c1 CHEMBL4750664 pKi 4.266 nM
O=C1NCc2ccc(OCCCN3CCN(c4cccc5c4CCO5)CC3)cc21 CHEMBL1257383 Ki 4.29 nM
CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCCCC(F)F)cc2)CC1 CHEMBL5175451 IC50 4.29 nM
CC(C)C1Cc2cc(CNC(=O)N(Cc3ccc(F)cn3)C3CCN(C)CC3)ccc2O1 CHEMBL5191581 IC50 4.29 nM
COc1cc(Cc2c(N)nc(SCCN3CCN(Cc4ccccc4Cl)CC3)nc2N)cc(OC)c1OC CHEMBL104709 Ki 4.3 nM
CC(=O)N1CCN(CCOc2ccc(NC(=O)c3cccc(C(F)(F)F)c3)cc2-c2ccnn2C)CC1 CHEMBL1086555 Ki 4.3 nM
O=C(c1cn2ccccc2n1)N1CCN(CCc2ccc(F)cc2F)CC1 CHEMBL1957810 Ki 4.3 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1)C1CC1 CHEMBL3676872 Ki 4.3 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3cccc4c3OCO4)CC2)CC1)C1CCS(=O)(=O)C1 CHEMBL3698002 Ki 4.3 nM
CO[C@H]1CC[C@H](CC(=O)N[C@H]2CC[C@H](CCN3CCN(c4nccc5sccc45)CC3)CC2)C1 CHEMBL3642703 Ki 4.3 nM
Nc1ccc2c(N3CCN(CC[C@H]4CC[C@H](NC(=O)c5ccco5)CC4)CC3)nsc2c1 CHEMBL3941190 Ki 4.3 nM
CN1CCN(Cc2ccc(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2)CC1 CHEMBL4846866 Ki 4.3 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1)c1ccccc1 CHEMBL3676854 Ki 4.36 nM
O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1cccc(Cl)c1 CHEMBL5082182 pKi 4.365 nM
CN(C)CCC=C1c2ccccc2CCc2ccccc21 CHEMBL629 Ki 4.374 nM
COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](CCN3CCC(c4noc5cc(F)ccc45)CC3)CC2)cc1 CHEMBL3966285 Ki 4.394 nM
CN(C)CCc1c(-c2ccccc2)[nH]c2ccccc12 CHEMBL91447 Ki 4.4 nM
O=S(=O)(c1ccc(F)cc1)N1CCN(CCc2ccc(F)cc2F)CC1 CHEMBL207850 Ki 4.4 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nccc4occc34)CC2)CC1)C1CC1 CHEMBL3642691 Ki 4.4 nM
COCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3nccc4occc34)CC2)CC1 CHEMBL3642686 Ki 4.4 nM
COCCOc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1ccnn1C CHEMBL3665545 IC50 4.4 nM
Fc1ccc2c(C3CCN(CCCOc4ccc(CN5CCOCC5)cc4)CC3)noc2c1 CHEMBL4870716 Ki 4.4 nM
CN(C)S(=O)(=O)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676888 Ki 4.41 nM
Nc1ccc2c(c1)C(O)C(CCN1CCC(C(=O)c3ccc(F)cc3O)CC1)CC2 CHEMBL3104523 pKi 4.467 nM
COc1cccc(C(=O)Nc2ccc(OCCN3CCN(C(C)=O)CC3)c(-c3ccnn3C)c2)c1 CHEMBL1085854 Ki 4.5 nM
Cn1cc(I)c(C(=O)N2CCN(CC(=O)c3ccc(F)cc3)CC2)n1 CHEMBL1214950 Ki 4.5 nM
Fc1ccc2c(C3CCN(CCCCOc4ccc(CN5CCOCC5)cc4)CC3)noc2c1 CHEMBL4856753 Ki 4.5 nM
CN1CCN(c2ccc(C(=O)N[C@H]3CC[C@H](CCN4CCN(c5nccc6c5CCO6)CC4)CC3)cc2)CC1 CHEMBL3642794 Ki 4.51 nM
CN1CCc2cc(NCc3ccccc3)c(O)cc2C(c2ccccc2)C1 CHEMBL3325904 Ki 4.52 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nccc4c3CCO4)CC2)CC1)c1ccc(N2CCOCC2)cc1 CHEMBL3642734 Ki 4.52 nM
CCC(=O)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676850 Ki 4.52 nM
NCCc1c[nH]c2cc(F)ccc12 CHEMBL381160 EC50 4.56 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3cccc4c3OCO4)CC2)CC1)C1CCS(=O)(=O)C1 CHEMBL3664864 Ki 4.57 nM
CSc1ncc2c(n1)CC(CN1CCC(c3noc4cc(F)ccc34)CC1)CC2=O CHEMBL566508 pKi 4.571 nM
COc1ccc2[nH]cc(CC(C)N)c2c1 CHEMBL31115 Ki 4.6 nM
[O-][S+](c1ccc(/C=C/c2ccc(F)cc2)nc1)c1ccccc1F CHEMBL395459 Ki 4.6 nM
Cc1c(Br)c(C(=O)N2CCN(CC(=O)c3ccc(F)cc3)CC2)nn1C CHEMBL1214878 Ki 4.6 nM
Cc1[nH]nc(C(=O)N2CCN(CC(=O)c3ccc(F)cc3)CC2)c1Br CHEMBL1214879 Ki 4.6 nM
CN1CCN2c3c(cccc31)[C@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@H]12 CHEMBL3233419 Ki 4.6 nM
OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1 CHEMBL53904 AC50 4.6 nM
COCCC(=O)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676847 Ki 4.63 nM
CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCCC(F)F)cc2)CC1 CHEMBL5198919 IC50 4.64 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3cccc4c3OCO4)CC2)CC1)C1(O)CCCCC1 CHEMBL3697987 Ki 4.69 nM
CN1CCCC(c2c(-c3ccccc3)[nH]c3ccccc23)C1 CHEMBL43819 Ki 4.7 nM
O=C(CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCN3Cc1ccccc1)c1ccc(F)cc1 CHEMBL3233147 Ki 4.7 nM
CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccncc3)CC[C@@H]12 CHEMBL3233407 Ki 4.7 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1)C1CCCOC1 CHEMBL3676871 Ki 4.7 nM
CN1CCN(Cc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2)CC1 CHEMBL4865907 Ki 4.7 nM
O=C(NC1CCc2ccc(CCN3CCN(c4nsc5ccccc45)CC3)cc21)c1ccccc1 CHEMBL253233 Ki 4.75 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1)c1ccc(C(F)(F)F)cc1 CHEMBL3676895 Ki 4.75 nM
CC(C)(O)C(=O)N[C@H]1CC[C@H](CCN2CCC(c3cccc4c3OCO4)CC2)CC1 CHEMBL3664845 Ki 4.77 nM
Cn1nc(C(=O)N2CCN(CC(=O)c3ccc(F)cc3)CC2)cc1-c1ccco1 CHEMBL3952456 IC50 4.8 nM
O=C1NCc2ccc(OCCCN3CCN(c4cccc5c4CCCC5)CC3)cc21 CHEMBL1257613 Ki 4.86 nM
NCCc1c[nH]c2ccc3c(c12)CCCO3 CHEMBL27173 Ki 4.9 nM
COc1cccc(C(=O)Nc2ccc(OCCN3CCOCC3)c(-c3ccnn3C)c2)c1 CHEMBL1084617 Ki 4.9 nM
O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(Cl)c(Cl)c1 CHEMBL3289994 Ki 4.9 nM
O=C(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)Nc1ccn2nccc2c1 CHEMBL4091155 Ki 4.9 nM
COc1cc(CN2CCOCC2)ccc1OCCCN1CCC(c2noc3cc(F)ccc23)CC1 CHEMBL4873319 Ki 4.9 nM
Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1 CHEMBL2393244 IC50 4.92 nM
O=C(CO)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676856 Ki 4.92 nM
O=C(CC1CCC1)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676893 Ki 4.94 nM
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5ccccc45)CC3)cc21 CHEMBL1258647 Ki 4.95 nM
Fc1ccc(CCN2CCC3(CCc4c(F)cccc4O3)CC2)c(F)c1 CHEMBL147164 Ki 5.0 nM
CN(C)C[C@@H]1C[C@H]2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1 CHEMBL363619 Ki 5.0 nM
CC(C)(C)c1nc2c(c(-c3ccc(F)cc3)n1)CNCC2 CHEMBL408155 Ki 5.0 nM
O=C(c1cc(Br)cn2ccnc12)N1CCN(CCc2ccc(F)cc2F)CC1 CHEMBL1957820 Ki 5.0 nM
FC(F)(COc1ccc(Cl)cc1OC1CNC1)c1ccccc1 CHEMBL3260336 Ki 5.0 nM
O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1 CHEMBL4250475 Ki 5.0 nM
O=c1n(CCCCCCN2CCN(c3nsc4ccccc34)CC2)nc2ccccn12 CHEMBL4648581 Ki 5.0 nM
CC(C)n1nc2c(c1-c1ccc(C#N)cc1)CCNCC2 CHEMBL4743582 Ki 5.0 nM
COc1ccc(NC(=O)c2ccc(-c3ccc(-c4noc(C)n4)cc3C)cc2)cc1NCCN(C)C CHEMBL282693 pKi 5.012 nM
CC(C)c1cc2c(cc1NS(=O)(=O)c1ccc(-c3ccc(Cl)cc3)cc1)CCN(C)CC2 CHEMBL397476 Log Ki 5.012 nM
CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(C)CC3)cc1 CHEMBL231334 Log Ki 5.012 nM
CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CN(C)C3)cc1 CHEMBL395501 Log Ki 5.012 nM
Cn1ncc(Br)c1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCc1ccccc1 CHEMBL598378 pKi 5.012 nM
Nc1ccc2c(c1)C(=O)C(CCN1CCC(c3noc4cc(F)ccc34)CC1)CC2 CHEMBL3104647 pKi 5.012 nM
Cc1nc2c(o1)CC(CN1CCC(c3c[nH]c4cc(F)ccc34)CC1)CC2=O CHEMBL3220215 pKi 5.012 nM
CCCc1cccc2c1CC[C@@H]1CNCCN21 CHEMBL4776557 pKi 5.012 nM
c1ccc2c(N3CCN(CCCCOc4ccc5c(c4)CNC5)CC3)cccc2c1 CHEMBL1258425 Ki 5.07 nM
CCS(=O)(=O)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676882 Ki 5.07 nM
CC(=O)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676846 Ki 5.08 nM
O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1 CHEMBL601887 IC50 5.1 nM
Cn1nccc1-c1cc(NC(=O)c2cccc(F)c2)ccc1OCCN1CCOCC1 CHEMBL1083751 Ki 5.1 nM
COc1cccc(C(=O)Nc2ccc(OCCN3CCN(C(N)=O)CC3)c(-c3ccnn3C)c2)c1 CHEMBL1083725 Ki 5.1 nM
O=[N+]([O-])c1ccc(CCN2CCN(c3ccccc3)CC2)cc1[N+](=O)[O-] CHEMBL2298799 Ki 5.1 nM
O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccs1 CHEMBL3289999 Ki 5.1 nM
Cc1cccc(N2CCN(CCCCNC(=O)[C@@H]3CCc4ccccc4N3)CC2)c1 CHEMBL3358508 Ki 5.1 nM
CC(C)(O)CC(=O)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676879 Ki 5.1 nM
Fc1ccc2c(C3CCN(CCCOc4ccc(CN5CCCCC5)cc4)CC3)noc2c1 CHEMBL4865735 Ki 5.1 nM
Cc1cc(OCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccc1CN1CCOCC1 CHEMBL4877973 Ki 5.1 nM
CC1CCN(CCc2ccc(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2)CC1 CHEMBL4861643 Ki 5.1 nM
Cc1ccc(C(=O)N[C@H]2CC[C@H](CCN3CCC(c4coc5ccccc45)CC3)CC2)cn1 CHEMBL3676914 Ki 5.11 nM
Cc1nc2n(c(=O)c1CCN1CCC(c3cccc4sccc34)CC1)CCCC2 CHEMBL4078409 IC50 5.12 nM
Cc1cccc(N2CCN(CCc3ccc4[nH]nnc4c3)CC2)c1C CHEMBL184770 Log Ki 5.129 nM
O=C1C[C@H](CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2occc21 CHEMBL523680 pKi 5.129 nM
O=S(=O)(N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)ccc34)CC2)CC1)c1ccc(Cl)cc1 CHEMBL3891987 Ki 5.132 nM
NCCc1c[nH]c2ccc(Br)cc12 CHEMBL1288717 EC50 5.14 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3cccc4c3OCO4)CC2)CC1)c1ccccc1 CHEMBL3664822 Ki 5.14 nM
O=C(CC1CC1)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676870 Ki 5.16 nM
CCCc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccc(OC)cc1 CHEMBL3215621 IC50 5.17 nM
CCCc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccc(OC)cc1 CHEMBL1852659 IC50 5.17 nM
Cc1nc2n(c(=O)c1CCN1CCN(c3nsc4ccccc34)CC1)CCCC2O CHEMBL4060678 IC50 5.18 nM
CN1CC(C)(C)N2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12 CHEMBL3233426 Ki 5.2 nM
Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O CHEMBL1621 IC50 5.2 nM
O=C1[C@@H]2[C@H]3CC[C@H](C3)[C@@H]2C(=O)N1CCCCN1CCC(c2noc3cc(F)ccc23)CC1 CHEMBL4280940 IC50 5.2 nM
Fc1ccc2c(C3CCN(CCCOc4ccc(CN5CCOCC5)c(F)c4)CC3)noc2c1 CHEMBL4878271 Ki 5.2 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1)c1ccc(-c2ccccc2)cc1 CHEMBL3676908 Ki 5.21 nM
CCc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4[nH]3)CC2)c1Cl CHEMBL4544583 Ki 5.22 nM
O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)c(Cl)c1 CHEMBL4775997 pKi 5.248 nM
O=C(CC1COC1)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676921 Ki 5.25 nM
COc1ccc2[nH]cc(CCNCc3ccccc3)c2c1 CHEMBL58083 Ki 5.3 nM
O=C(c1ccc(F)cc1)C1CCN(CCCCc2ccccc2)CC1 CHEMBL19259 Ki 5.3 nM
Cn1ncc(Cl)c1-c1cc(NC(=O)c2cccc(C(F)(F)F)c2)ccc1OCCN1CCNC(=O)C1 CHEMBL1084865 Ki 5.3 nM
Clc1cccc(N2CCN(CCCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl CHEMBL3613879 Ki 5.3 nM
CS(=O)(=O)CC(=O)N[C@H]1CC[C@H](CCN2CCC(c3cccc4occc34)CC2)CC1 CHEMBL3695364 Ki 5.3 nM
CN(C)S(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(c3nccc4occc34)CC2)CC1 CHEMBL3642695 Ki 5.3 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nccc4occc34)CC2)CC1)c1ccnc2ccccc12 CHEMBL3642706 Ki 5.3 nM
O=C(CC1CCOCC1)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676849 Ki 5.37 nM
O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2cc(Cl)ccc2c1 CHEMBL4760655 pKi 5.37 nM
CN1CCN(C2=Cc3ccccc3Cn3cccc32)CC1 CHEMBL179775 Ki 5.4 nM
O=S(=O)(c1ccc(/C=C/c2ccc(F)cc2)nc1)c1ccccc1F CHEMBL240454 Ki 5.4 nM
CNc1cc(OC)c(C(=O)NC2CCN(Cc3ccccc3)C2C)cc1Cl CHEMBL20734 AC50 5.4 nM
O=C1NCc2ccc(OCCCN3CCN(c4cccc5cc(F)ccc45)CC3)c(F)c21 CHEMBL1258314 Ki 5.41 nM
CS(=O)(=O)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676881 Ki 5.43 nM
O=C(CC1CCCO1)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676874 Ki 5.43 nM
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5c4COCC5)CC3)cc21 CHEMBL1257857 Ki 5.44 nM
O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2occc21 CHEMBL143027 pKi 5.495 nM
O=C(CCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CCN3)c1ccc(F)cc1 CHEMBL3233422 Ki 5.5 nM
O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccs1 CHEMBL3289951 Ki 5.5 nM
CCCC(=O)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676878 Ki 5.53 nM
CCCN(CC)CCc1c[nH]c2ccc(F)cc12 CHEMBL4877402 EC50 5.54 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1)C1CCC1 CHEMBL3676865 Ki 5.56 nM
CC(C)(C)Oc1ccc(C(=O)N[C@H]2CC[C@H](CCN3CCC(c4coc5ccccc45)CC3)CC2)cc1 CHEMBL3676916 Ki 5.56 nM
COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 CHEMBL296419 Ki 5.575 nM
O=C(c1cc2ncccn2n1)N1CCN(CCc2ccc(F)cc2F)CC1 CHEMBL1957806 Ki 5.6 nM
CO[C@H]1CC[C@H](CC(=O)N[C@H]2CC[C@H](CCN3CCN(c4nccc5occc45)CC3)CC2)CC1 CHEMBL3642687 Ki 5.6 nM
O=C(CO)N[C@H]1CC[C@H](CCN2CCN(c3nccc4occc34)CC2)CC1 CHEMBL3642685 Ki 5.6 nM
CCC(=O)N[C@H]1CC[C@H](CCN2CCC(c3cccc4occc34)CC2)CC1 CHEMBL3695362 Ki 5.6 nM
N#Cc1cnn2ccc(NC(=O)CCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12 CHEMBL4091064 Ki 5.6 nM
Fc1ccc2c(C3CCN(CCCOc4ccc(CN5CCOCC5)cc4F)CC3)noc2c1 CHEMBL4860828 Ki 5.6 nM
O=c1n(CCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccn12 CHEMBL621 Ki 5.602 nM
COc1cc2c(cc1OC)C(=O)CC(CN1CCC(C(=O)c3ccc(F)cc3)CC1)C2 CHEMBL155388 Log Ki 5.623 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1)c1ccc(F)cc1 CHEMBL3676869 Ki 5.66 nM
Cc1cnc(N2CCN(CC[C@H]3CC[C@H](NC(=O)C4CCOCC4)CC3)CC2)c2ccoc12 CHEMBL3642781 Ki 5.67 nM
COc1ccc(Cc2c(N)nc(SCCN3CCN(Cc4ccccc4Cl)CC3)nc2N)cc1 CHEMBL324892 Ki 5.7 nM
O=C(c1cc2ccccn2n1)N1CCN(CCc2ccc(F)cc2F)CC1 CHEMBL1957800 Ki 5.7 nM
CC1CN(C)c2cccc3c2N1[C@H]1CCN(CCCC(=O)c2ccc(F)cc2)C[C@@H]31 CHEMBL3233425 Ki 5.7 nM
O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1csc2ccccc12 CHEMBL3290010 Ki 5.7 nM
Fc1ccc2c(C3CCN(CCCOc4ccc(CN5CCOCC5)cc4Cl)CC3)noc2c1 CHEMBL4853342 Ki 5.7 nM
CC(C)C(=O)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676859 Ki 5.75 nM
O=C1COc2ccccc2N1CCCN1CCN(c2nsc3ccccc23)CC1 CHEMBL4090568 pKi 5.754 nM
COc1ccc2cc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)ccc2c1 CHEMBL4764557 pKi 5.754 nM
CC(C)(O)C(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc4c3OCO4)CC2)CC1 CHEMBL3697974 Ki 5.79 nM
CS(=O)(=O)c1ccc(C(=O)N[C@H]2CC[C@H](CCN3CCC(c4coc5ccccc45)CC3)CC2)cc1 CHEMBL3676931 Ki 5.79 nM
C[C@H](N)Cn1ncc2ccc(O)c(F)c21 CHEMBL197653 Ki 5.8 nM
CCc1nn(CCCN2CCN(c3cccc(Cl)c3)CC2)c(=O)n1CCOc1ccccc1 CHEMBL623 Ki 5.8 nM
CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccccc3)CC[C@@H]12 CHEMBL3233406 Ki 5.8 nM
CC(=O)N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1 CHEMBL3973487 Ki 5.8 nM
Fc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1 CHEMBL81330 Ki 5.8 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1)c1ccc(C2CCCCC2)cc1 CHEMBL3676927 Ki 5.81 nM
O=C(CC1CCCCO1)N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(Cl)ccc34)CC2)CC1 CHEMBL3915600 Ki 5.829 nM
Cc1cccc(S(=O)(=O)CC2CCN(CCCc3noc4cc(F)ccc34)C2)c1 CHEMBL5080305 pKi 5.888 nM
N#Cc1ccc(C(=O)N[C@H]2CC[C@H](CCN3CCC(c4coc5ccccc45)CC3)CC2)cc1 CHEMBL3676915 Ki 5.89 nM
O=C(c1cnn2cc(Cl)ccc12)N1CCN(CCc2ccc(F)cc2F)CC1 CHEMBL1957804 Ki 5.9 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nccc4c3CCO4)CC2)CC1)C1CCOCC1 CHEMBL3642710 Ki 5.9 nM
CN1CCC(C(=O)N[C@H]2CC[C@H](CCN3CCC(c4cccc5c4OCO5)CC3)CC2)CC1 CHEMBL3664873 Ki 5.91 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nccc4c3CCO4)CC2)CC1)C1(O)CC1 CHEMBL3642735 Ki 5.92 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1)C1CCOC1 CHEMBL3676862 Ki 5.93 nM
COC(CC(=O)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1)OC CHEMBL3676897 Ki 5.94 nM
N#CCC(=O)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676868 Ki 5.96 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3cccc4c3OCO4)CC2)CC1)C1(O)CCC1 CHEMBL3697985 Ki 5.98 nM
CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1 CHEMBL435301 Ki 6.0 nM
CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2NC1 CHEMBL21343 IC50 6.0 nM
O=C1Cc2c(ccc3c2OC[C@H](CNCCCC2CCc4c([nH]c5ccc(F)cc45)C2)O3)N1 CHEMBL566379 Ki 6.0 nM
O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccccc2s1 CHEMBL3289958 Ki 6.0 nM
Cc1ccc2[nH]cc(CCN)c2c1 CHEMBL331241 EC50 6.0 nM
CC(=O)c1c(OCCCN2CCN(c3cccc(Br)c3)CC2)ccc2c(C)cc(=O)oc12 CHEMBL4215550 Ki 6.0 nM
O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1 CHEMBL4245263 Ki 6.0 nM
O=c1oc2ccccc2n1CCCCCCN1CCN(c2nsc3ccccc23)CC1 CHEMBL4643450 Ki 6.0 nM
O=c1[nH]c2ccccc2n1CCCCCCN1CCN(c2nsc3ccccc23)CC1 CHEMBL4638308 Ki 6.0 nM
Fc1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1 CHEMBL4762886 Ki 6.0 nM
CC(C)(C)C1CCC(C(=O)N[C@H]2CC[C@H](CCN3CCC(c4coc5ccccc45)CC3)CC2)CC1 CHEMBL3676922 Ki 6.03 nM
CC(C)(C)C(=O)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676873 Ki 6.05 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1)C(O)C(F)(F)F CHEMBL3676877 Ki 6.08 nM
O=S(=O)(c1ccccc1Cl)N1CCC(CCc2ccc(F)cc2F)CC1 CHEMBL210413 Ki 6.1 nM
Cn1nccc1-c1cc(NC(=O)Nc2ccccc2F)ccc1OCCN1CCCCC1 CHEMBL566383 Ki 6.1 nM
O=C(CC1CCOCC1)N[C@H]1CC[C@H](CCN2CCN(c3nccc4occc34)CC2)CC1 CHEMBL3642688 Ki 6.1 nM
C[C@]1(O)CC[C@@H](C(=O)N[C@H]2CC[C@H](CCN3CCN(c4nccc5c4CCO5)CC3)CC2)CC1 CHEMBL3642732 Ki 6.14 nM
O=C(C[C@H]1CCCO1)N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(Cl)ccc34)CC2)CC1 CHEMBL4113529 Ki 6.193 nM
Cc1c(Cl)ccc2c1N1CCNC[C@H]1C2 CHEMBL187739 Ki 6.2 nM
CC(CCN1CCN(c2ccc(F)cc2)CC1)NS(=O)(=O)c1ccc2ccccc2c1 CHEMBL602279 IC50 6.2 nM
Fc1ccc2c(C3CCN(CCCOc4ccc(CN5CCCCC5)c(F)c4)CC3)noc2c1 CHEMBL4876719 Ki 6.2 nM
CC(N)Cc1c[nH]c2ccc(Cl)cc12 CHEMBL1906905 EC50 6.27 nM
COC1(C(=O)N[C@H]2CC[C@H](CCN3CCN(c4cccc5c4OCO5)CC3)CC2)CC1 CHEMBL3698012 Ki 6.27 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nccc4c3CCO4)CC2)CC1)C1CCCO1 CHEMBL3642720 Ki 6.3 nM
O=Cc1cnn2ccc(NC(=O)CCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12 CHEMBL4060403 Ki 6.3 nM
Fc1ccc2c(C3CCN(CCCOc4ccc(CN5CCOCC5)c(Cl)c4)CC3)noc2c1 CHEMBL4863980 Ki 6.3 nM
COc1ccc(NC(=O)c2ccc(-c3ccc(-c4noc(C)n4)cc3C)cc2)cc1CCCN(C)C CHEMBL21790 pKi 6.31 nM
COc1cc(Cl)c(Cl)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O CHEMBL91221 Log Ki 6.31 nM
COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNCC5)cc4=O)c3C)cc2)cn1 CHEMBL475965 pKi 6.31 nM
Cn1ncc(Br)c1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCCc1ccccc1 CHEMBL597152 pKi 6.31 nM
CCCc1cccc2c1CCC1CNCCN21 CHEMBL3947276 pKi 6.31 nM
CCCc1ccnc2c1CC[C@@H]1CNCCN21 CHEMBL4765074 pKi 6.31 nM
O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc(F)c(Cl)c1 CHEMBL5080955 pKi 6.31 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nccc4c3CCO4)CC2)CC1)C1CCCOC1 CHEMBL3642730 Ki 6.37 nM
CO[C@@H]1CC[C@@H](CC(=O)N[C@H]2CC[C@H](CCN3CCN(c4nccc5occc45)CC3)CC2)C1 CHEMBL3642680 Ki 6.4 nM
Cc1nc2n(c(=O)c1CCN1CCN(c3nsc4ccccc34)CC1)CCCC2=O CHEMBL4084663 IC50 6.4 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3cccc4c3OCO4)CC2)CC1)C1COc2ccccc2C1 CHEMBL3698000 Ki 6.41 nM
CNc1ncc2c(n1)CC(CN1CCC(C(=O)c3ccc(F)cc3)CC1)CC2=O CHEMBL583772 pKi 6.457 nM
O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)c(Cl)c1 CHEMBL4750587 pKi 6.457 nM
Clc1c2n(c3ccccc13)CCNCC2 CHEMBL77234 Ki 6.5 nM
O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1 CHEMBL3289960 Ki 6.5 nM
Cc1c(S(=O)(=O)NCCCCN2CCN(c3nsc4ccccc34)CC2)sc2ccc(F)cc12 CHEMBL3289962 Ki 6.5 nM
O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cnc2ccccn12 CHEMBL3290018 Ki 6.5 nM
CCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3nccc4occc34)CC2)CC1 CHEMBL3642682 Ki 6.5 nM
CC(=O)c1c(OCCCCN2CCN(c3cccc(Br)c3)CC2)ccc2c(C)cc(=O)oc12 CHEMBL4214598 Ki 6.5 nM
Fc1ccc2c(C3CCN(CCCOc4ccc(CN5CCCCC5)cc4F)CC3)noc2c1 CHEMBL4859348 Ki 6.5 nM
CCC(C)C(=O)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676876 Ki 6.56 nM
CNCc1ccc(Cl)cc1Oc1ccc(Cl)cc1 CHEMBL462387 IC50 6.59 nM
Nc1ccccc1C(=O)CCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CCS3 CHEMBL351459 Ki 6.6 nM
Nc1ccc2c(c1)C(O)C(CCN1CCC(c3noc4cc(F)ccc34)CC1)CC2 CHEMBL3104522 pKi 6.607 nM
CN(C)CCCN1c2ccccc2Sc2ccccc21 CHEMBL564 Ki 6.695 nM
C[C@H](N)Cn1ncc2ccc3sccc3c21 CHEMBL406851 Ki 6.7 nM
O=C1CCc2ccc(OCCCCN3CCN(c4c(F)ccc5ccccc45)CC3)nc2N1 CHEMBL1774081 Ki 6.7 nM
COc1cc2c(cc1OC)C1CC(O)C(CC(C)C)CN1CC2 CHEMBL4206824 Ki 6.7 nM
CS(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(c3nccc4occc34)CC2)CC1 CHEMBL3642692 Ki 6.8 nM
CC(=O)N[C@H]1CC[C@H](CCN2CCC(c3cccc4occc34)CC2)CC1 CHEMBL3695354 Ki 6.8 nM
CNC(C)c1ccc(Cl)cc1Oc1ccc(C)c(C)c1 CHEMBL513629 IC50 6.82 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1)c1ccc(N2CCCCC2)cc1 CHEMBL3676896 Ki 6.85 nM
CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(F)(F)F)c(F)c2)CC1 CHEMBL5185362 IC50 6.86 nM
CO[C@@H](C)C(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc4c3OCO4)CC2)CC1 CHEMBL3697976 Ki 6.89 nM
Cc1cccc(N2CCN(CCCNC(=O)c3cc(-c4ccccc4)n(-c4ccc(F)cc4)c3C)CC2)c1C CHEMBL1087773 IC50 6.9 nM
O=Cc1cnn2ccc(-n3cc(CCCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12 CHEMBL3613874 Ki 6.9 nM
O=C1c2ccccc2CCCN1CCN1CCC(n2ccc3cc(F)ccc32)CC1 CHEMBL9951 Log Ki 6.918 nM
CN(C)CC1CC2c3ccccc3Cc3cc(F)ccc3N2O1 CHEMBL84081 pIC50 6.918 nM
O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2oc(-c3ccccc3)cc21 CHEMBL516809 pKi 6.918 nM
Cc1c(S(=O)(=O)N[C@H]2C[C@H](C)N(CCCc3noc4cc(F)ccc34)C2)sc2ccc(Cl)cc12 CHEMBL5079536 pKi 6.918 nM
CN1[C@@H]2CC[C@H]1C[C@@H](OC(c1ccccc1)c1ccccc1)C2 CHEMBL1201203 Ki 6.968 nM
CCCCCCc1ccc2c(c1)Cc1ccccc1C2CN CHEMBL86760 Ki 7.0 nM
CO[C@H](C)C(=O)N[C@H]1CC[C@H](CCN2CCN(c3nccc4c3CCO4)CC2)CC1 CHEMBL3642811 Ki 7.0 nM
CC(=O)c1c(OCCCN2CCN(c3ccccc3Br)CC2)ccc2c(C)cc(=O)oc12 CHEMBL4218720 Ki 7.0 nM
O=S(=O)(c1cccc2ncccc12)N1CC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1 CHEMBL4243932 Ki 7.0 nM
CCc1cccc(N2CCNCC2)c1Cl CHEMBL4441358 Ki 7.0 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3noc4ccc(F)cc34)CC2)CC1)c1ccc(N2CCCCC2)cc1 CHEMBL3937844 Ki 7.004 nM
O=S(=O)(c1ccc(C(F)(F)F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1 CHEMBL602274 IC50 7.1 nM
Clc1cccc(N2CCN(CCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl CHEMBL3613878 Ki 7.1 nM
COCCC(=O)N[C@H]1CC[C@H](CCN2CCC(c3cccc4occc34)CC2)CC1 CHEMBL3695355 Ki 7.1 nM
Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2(F)F CHEMBL4096467 IC50 7.1 nM
COc1ccc2[nH]cc(CCN3CCC3)c2c1 CHEMBL5078999 EC50 7.15 nM
CCNCCc1c[nH]c2ccc(OC)cc12 CHEMBL57888 Ki 7.2 nM
Clc1cccc(N2CCNCC2)c1 CHEMBL478 EC50 7.2 nM
O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 CHEMBL139926 Ki 7.2 nM
CN1CC=C(C2=Nc3cc(Cl)ccc3Nc3ccc(F)cc32)CC1 CHEMBL4852403 INH 7.2 nM
COc1c(Br)cc([18F])cc1CCNCc1ccccc1O CHEMBL5172222 Ki 7.2 nM
Clc1ccc2[nH]cc(C3=CCCNC3)c2c1 CHEMBL5428466 EC50 7.2 nM
Fc1ccc(Cl)c2[nH]nc(C3=CCCNC3)c12 CHEMBL5440436 EC50 7.2 nM
COc1cc2c(cc1OC)C(=O)CC(CN1CCC(c3noc4cc(F)ccc34)CC1)C2 CHEMBL155257 Log Ki 7.244 nM
O=C1NCCN1CCN1CCC(c2c(-c3ccccc3)[nH]c3ccccc23)CC1 CHEMBL330454 Ki 7.3 nM
NCCc1c[nH]c2ccccc12 CHEMBL6640 EC50 7.36 nM
O=S(=O)(c1ccccc1)c1ccc(/C=C/c2ccc(F)cc2)nc1 CHEMBL394729 Ki 7.4 nM
Cc1c(S(=O)(=O)NCCCCN2CCN(c3noc4ccccc34)CC2)sc2ccc(F)cc12 CHEMBL3289986 Ki 7.4 nM
Cc1c(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nnn1Cc1ccccc1 CHEMBL373873 Ki 7.4 nM
CCOCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3nccc4occc34)CC2)CC1 CHEMBL3642690 Ki 7.4 nM
O=C1CCc2ccc(OCCCCN3CCCN(c4cccc(Cl)c4Cl)CC3)nc2N1 CHEMBL2165119 Ki 7.4 nM
CS(=O)(=O)Nc1cc(F)ccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCCS3 CHEMBL162102 Ki 7.5 nM
C[C@@H]1CNC[C@H]2Cc3ccc(C(F)(F)F)cc3N21 CHEMBL361079 Ki 7.5 nM
COc1ccc2c(c1)Cc1ccccc1C2CN CHEMBL83081 Ki 7.5 nM
CC(C)N1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12 CHEMBL3233145 Ki 7.5 nM
O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2scnc12 CHEMBL3289966 Ki 7.5 nM
O=C(CN1CCC(CN2Cc3ccccc3C2=O)CC1)c1ccc(F)cc1 CHEMBL4297605 Ki 7.5 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1)c1ccc(N2CCOCC2)nc1 CHEMBL3676910 Ki 7.56 nM
O=C(c1ccc(F)cc1)C1CCN(CCn2cnc3c(c2=O)CCCC3)CC1 CHEMBL5290270 pKi 7.586 nM
Nc1c(F)cccc1C(=O)CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCCS3 CHEMBL165126 Ki 7.6 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nccc4c3CCO4)CC2)CC1)c1ccccc1 CHEMBL3642721 Ki 7.63 nM
Cc1nc2n(c(=O)c1CCN1CCC(c3cccc4sccc34)CC1)CCCC2O CHEMBL4094926 IC50 7.66 nM
CO[C@H]1CC[C@H](CC(=O)N[C@H]2CC[C@H](CCN3CCC(c4noc5cc(F)c(F)cc45)CC3)CC2)CC1 CHEMBL3900302 Ki 7.67 nM
[O-][S+](c1ccccc1)c1ccc(/C=C/c2ccc(F)cc2)nc1 CHEMBL240886 Ki 7.7 nM
O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)CC1CCCCC1 CHEMBL604952 IC50 7.7 nM
O=C(CCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CCC3)c1ccc(F)cc1 CHEMBL3233428 Ki 7.7 nM
O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1 CHEMBL3289980 Ki 7.7 nM
C=CCN1C[C@H](C(=O)N(CCCN(C)C)C(=O)NCC)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21 CHEMBL1201087 AC50 7.7 nM
Cc1cc(CC(=O)N[C@H]2CC[C@H](CCN3CCC(c4coc5ccccc45)CC3)CC2)on1 CHEMBL3676855 Ki 7.71 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3cccc4c3OCO4)CC2)CC1)C1CCOCC1 CHEMBL3697993 Ki 7.74 nM
COc1cc(CCNCc2cccc3nc[nH]c23)c(OC)cc1Br CHEMBL3589583 pKi 7.762 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3cccc4c3OCO4)CC2)CC1)C1(O)CC1 CHEMBL3697979 Ki 7.77 nM
O=C(C[C@H]1COCCO1)N[C@H]1CC[C@H](CCN2CCN(c3cccc4c3OCO4)CC2)CC1 CHEMBL3697954 Ki 7.78 nM
CN1CCC(c2c(-c3ccccc3)[nH]c3ccccc23)CC1 CHEMBL91667 Ki 7.8 nM
CN(C)C(=O)CCC(=O)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676887 Ki 7.8 nM
CC(=O)Nc1ccc(OCCCN2CCC(c3noc4cc(F)ccc34)CC2)cc1 CHEMBL4784373 Ki 7.8 nM
CC(C)(O)C(=O)N[C@H]1CC[C@H](CCN2CCN(c3nccc4c3CCO4)CC2)CC1 CHEMBL3642800 Ki 7.82 nM
O=C(C[C@H]1CC[C@H](O)CC1)N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)c(F)cc34)CC2)CC1 CHEMBL3934933 Ki 7.848 nM
CS(=O)(=O)c1ccc(C(=O)N[C@H]2CC[C@H](CCN3CCC(c4coc5ccccc45)CC3)CC2)s1 CHEMBL3676920 Ki 7.85 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)c(F)cc34)CC2)CC1)C1CCOCC1 CHEMBL3910962 Ki 7.86 nM
CC#CC(=O)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676900 Ki 7.89 nM
O/N=C/c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1 CHEMBL3287404 Ki 7.9 nM
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5cc(F)c(F)cc45)CC3)cc21 CHEMBL1257261 Ki 7.91 nM
Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cnccc3C)nc1)CC2 CHEMBL55331 Log Ki 7.943 nM
C1=C(N2CCNCC2)c2nccn2Cc2ccccc21 CHEMBL1222552 pKi 7.943 nM
O=C1CC(CN2CCC(c3c[nH]c4cc(F)ccc34)CC2)Cc2nc(N3CCCC3)sc21 CHEMBL3220219 pKi 7.943 nM
c1cc(CC2CCC2)c2c(c1)N1CCNCC1CC2 CHEMBL3912721 pKi 7.943 nM
CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2 CHEMBL4753511 pKi 7.943 nM
CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 CHEMBL1385840 Ki 7.995 nM
CC1SC(C)(C)C(=O)N1CCCCN1CCN(c2csc3cc(F)ccc23)CC1 CHEMBL89934 Ki 8.0 nM
O=C(NCCCCN1CCN(c2ccc(F)cc2)CC1)c1cc2ccccc2cn1 CHEMBL3358499 Ki 8.0 nM
CC(C)(O)C(=O)N[C@H]1CC[C@H](CCN2CCC(c3cccc4c3CCO4)CC2)CC1 CHEMBL3695391 Ki 8.0 nM
CC(=O)c1c(OCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc2c(C)cc(=O)oc12 CHEMBL4130301 Ki 8.0 nM
COc1ccccc1N1CCN(CCCOc2ccc3c(C)cc(=O)oc3c2C(C)=O)CC1 CHEMBL4215022 Ki 8.0 nM
O=C(CC(F)(F)F)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676857 Ki 8.06 nM
N#Cc1ccccc1S(=O)(=O)N1CCC(CCc2ccc(F)cc2F)CC1 CHEMBL206307 Ki 8.1 nM
O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1 CHEMBL3289956 Ki 8.1 nM
O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cnc2ccccn12 CHEMBL3289964 Ki 8.1 nM
COCCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3nccc4occc34)CC2)CC1 CHEMBL3642683 Ki 8.1 nM
O=S(=O)(N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1)c1cccnc1 CHEMBL3933256 Ki 8.1 nM
CO[C@H]1CC[C@H](CC(=O)N[C@H]2CC[C@H](CCN3CCC(c4coc5ccccc45)CC3)CC2)CC1 CHEMBL3676917 Ki 8.14 nM
O=C(C[C@H]1COCCO1)N[C@H]1CC[C@H](CCN2CCN(c3nccc4c3CCO4)CC2)CC1 CHEMBL3642744 Ki 8.15 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3cccc4c3OCO4)CC2)CC1)C1(O)CC1 CHEMBL3664861 Ki 8.17 nM
Cn1cc(CCN)c2c3c(ccc21)OCCC3 CHEMBL25800 Ki 8.2 nM
Cc1cc(F)ccc1/C=C/c1ccc(S(=O)(=O)c2ccccc2F)cn1 CHEMBL240680 Ki 8.2 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1)c1cnc(N2CCOCC2)cn1 CHEMBL3676912 Ki 8.2 nM
CN1CCN2c3ncccc3Cc3ccccc3C2C1 CHEMBL654 Ki 8.2 nM
O=C(Cc1noc2ccccc12)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676930 Ki 8.22 nM
O=C(CCO)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676866 Ki 8.26 nM
O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1 CHEMBL602889 IC50 8.3 nM
CC(C)Cc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1 CHEMBL5208211 IC50 8.3 nM
COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1 CHEMBL5170784 EC50 8.3 nM
O=C(CC1CCC2(CC1)OCCO2)N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(Cl)ccc34)CC2)CC1 CHEMBL3964426 Ki 8.31 nM
CCOC(=O)c1oc2c(c1C)C(=O)CC(CN1CCC(c3noc4cc(F)ccc34)CC1)C2 CHEMBL459930 pKi 8.318 nM
CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCN(C(=O)CC[C@H](N)C(=O)O)CC2)cc1 CHEMBL4638345 IC50 8.35 nM
O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2scnc12 CHEMBL3289965 Ki 8.4 nM
CN1CCN(c2ccc(C(=O)N[C@H]3CC[C@H](CCN4CCC(c5cccc6c5CCO6)CC4)CC3)cc2)CC1 CHEMBL3695397 Ki 8.4 nM
Fc1ccc2c(C3CCN(CCCOc4ccc(CCN5CCOCC5)cc4)CC3)noc2c1 CHEMBL4867978 Ki 8.4 nM
CC(N)Cc1c[nH]c2ccc(F)cc12 CHEMBL96816 EC50 8.47 nM
Cc1cc(C(=O)N2CCN(CC(=O)c3ccc(F)cc3)CC2)nn1C CHEMBL1214881 Ki 8.5 nM
O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2scnc12 CHEMBL3290021 Ki 8.5 nM
CCS(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(c3nccc4occc34)CC2)CC1 CHEMBL3642694 Ki 8.5 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1)C1CC1(F)F CHEMBL3676875 Ki 8.59 nM
Cn1nccc1-c1cc(NC(=O)c2ccc(F)cc2F)ccc1OCCN1CCOCC1 CHEMBL1083750 Ki 8.6 nM
Fc1ccc2c(C3CCN(CCCOc4ccc(CN5CCCC5)cc4)CC3)noc2c1 CHEMBL4852663 Ki 8.6 nM
CN1CCN(CCc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2)CC1 CHEMBL4857918 Ki 8.6 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1)C(F)(F)F CHEMBL3676884 Ki 8.62 nM
Cc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccc2c(c1)OCCO2 CHEMBL3215630 IC50 8.63 nM
Cc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccc2c(c1)OCCO2 CHEMBL1852503 IC50 8.63 nM
CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1 CHEMBL5184703 IC50 8.64 nM
CC(C)CC(=O)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676860 Ki 8.65 nM
COc1nn(C[C@H](C)N)c2c1ccc1occc12 CHEMBL262092 Ki 8.7 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1)c1ccnc2ccccc12 CHEMBL3676864 Ki 8.7 nM
CC[C@@H](O)CC(=O)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676891 Ki 8.7 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1)c1ccc2c(c1)OCO2 CHEMBL3676903 Ki 8.78 nM
C[C@@H](O)C(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc4c3OCO4)CC2)CC1 CHEMBL3697992 Ki 8.78 nM
Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CCCNC3)cc1 CHEMBL404581 Ki 8.8 nM
Cc1cccc(S(=O)(=O)NCCN2CCN(c3nsc4ccccc34)CC2)c1 CHEMBL3289708 Ki 8.8 nM
O=C(C[C@H]1CC[C@H](O)CC1)N[C@H]1CC[C@H](CCN2CCN(c3nccc4occc34)CC2)CC1 CHEMBL3642681 Ki 8.8 nM
CN1CN(c2ccccc2)C2(CCN(CCCC(=O)c3ccc(F)cc3)CC2)C1=O CHEMBL267932 Ki 8.8 nM
CN1CCN(c2ccc(C(=O)N[C@H]3CC[C@H](CCN4CCC(c5coc6ccccc56)CC4)CC3)cc2)CC1 CHEMBL3676907 Ki 8.83 nM
O=C1NCc2cc(Cl)c(OCCCN3CCN(c4cccc5cccc(F)c45)CC3)cc21 CHEMBL1257384 Ki 8.84 nM
CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(F)(F)F)c(Br)c2)CC1 CHEMBL5200788 IC50 8.85 nM
O=C(CCCN1CCCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1 CHEMBL4574793 Ki 8.9 nM
Cc1c(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(Cl)cc12 CHEMBL4790020 pKi 8.913 nM
CN1CCC(=C2c3ccccc3CC(=O)c3sccc32)CC1 CHEMBL534 Ki 8.977 nM
c1ccc(-c2[nH]c3ccccc3c2CCN2CCCC2)cc1 CHEMBL90347 Ki 9.0 nM
Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CCNC3)cc1 CHEMBL403764 Ki 9.0 nM
O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(F)c(Cl)c1 CHEMBL3289996 Ki 9.0 nM
O=C(CC1CCOCC1)N[C@H]1CC[C@H](CCN2CCC(c3cccc4occc34)CC2)CC1 CHEMBL3695357 Ki 9.0 nM
O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1 CHEMBL4244691 Ki 9.0 nM
CC(=O)c1c(C)cc2oc(=O)cc(C)c2c1OCCCCN1CCN(c2ccccc2F)CC1 CHEMBL4287144 Ki 9.0 nM
CCOC(=O)Cc1nn(CNC(=O)CCCN2CCN(c3ccc(C)c(C)c3)CC2)c(=O)c2ccccc12 CHEMBL4637884 IC50 9.0 nM
COc1cc(CN2CCCCC2)ccc1OCCCN1CCC(c2noc3cc(F)ccc23)CC1 CHEMBL4870307 Ki 9.0 nM
CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1 CHEMBL2104523 AC50 9.0 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1)c1ccc(Cl)cc1 CHEMBL3676894 Ki 9.01 nM
COc1cccc2[nH]cc(CCN)c12 CHEMBL343529 EC50 9.02 nM
N#Cc1ccc(C(=O)N[C@H]2CC[C@H](CCN3CCC(c4cccc5c4OCO5)CC3)CC2)cc1 CHEMBL3664827 Ki 9.02 nM
CNCc1ccc(Cl)cc1Oc1ccc(Cl)c(C)c1 CHEMBL452091 IC50 9.04 nM
C[C@H](N)Cn1ncc2ccc(Cl)c(Cl)c21 CHEMBL264172 Ki 9.1 nM
COc1cccc(Nc2nc(N3CCN(C)CC3)nc3[nH]ncc23)c1 CHEMBL2393402 IC50 9.1 nM
O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cccs1 CHEMBL3289950 Ki 9.1 nM
O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2scnc12 CHEMBL3290020 Ki 9.1 nM
CC(=O)N[C@H]1CC[C@H](CCN2CCN(c3nccc4occc34)CC2)CC1 CHEMBL3639415 Ki 9.1 nM
CC[C@H](O)CC(=O)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676892 Ki 9.1 nM
CNCc1ccc(Cl)cc1Oc1ccc(C)c(Cl)c1 CHEMBL451330 IC50 9.11 nM
Cn1ccc2c(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)cccc21 CHEMBL4742856 pKi 9.12 nM
Fc1ccc(CCCCN2CCN(c3ccc(Cl)cn3)CC2)cc1 CHEMBL4462108 pKi 9.12 nM
Cc1nc2ccccn2c(=O)c1CCN1CCN(c2cccc3sccc23)CC1 CHEMBL4094825 IC50 9.14 nM
CN1CCC[C@@H]1CCO[C@](C)(c1ccccc1)c1ccc(Cl)cc1 CHEMBL1626 Ki 9.196 nM
COc1cc2c3c(c1OCc1ccc(Br)cc1)-c1cc4c(cc1CC3N(C)CC2)OCO4 CHEMBL3633757 Ke(app) 9.2 nM
Cc1cc(C(=O)N[C@H]2CC[C@H](CCN3CCC(c4coc5ccccc45)CC3)CC2)on1 CHEMBL3676886 Ki 9.21 nM
Cc1cc(C(=O)N2CCN(CC(=O)c3ccc(F)cc3)CC2)nn1C(C)(C)C CHEMBL1214882 Ki 9.3 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3cccc4c3CCO4)CC2)CC1)C1(O)CC1 CHEMBL3695381 Ki 9.3 nM
O=S(=O)(c1ccccc1)N(CCCN1CCC(c2noc3cc(F)ccc23)CC1)C1COC1 CHEMBL4776840 IC50 9.3 nM
O=C(c1ccc([N+](=O)[O-])cc1)C1CCN(CCc2ccccc2)CC1 CHEMBL75723 Ki 9.34 nM
O=C(CC1OCCCO1)N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)c(F)cc34)CC2)CC1 CHEMBL3921063 Ki 9.394 nM
COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1 CHEMBL601872 IC50 9.4 nM
CC(C)(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(c3nccc4c3CCO4)CC2)CC1 CHEMBL3642747 Ki 9.4 nM
Fc1ccc2c(C3CCN(CCCOc4ccc(CCN5CCCCC5)cc4)CC3)noc2c1 CHEMBL4861311 Ki 9.4 nM
Cc1c(OCCCN2CCN(c3cccc4ccccc34)CC2)ccc2c1C(=O)NC2 CHEMBL1257494 Ki 9.43 nM
Clc1ccc2c(c1)CCc1cccnc1C2=C1CCNCC1 CHEMBL1172 Ki 9.45 nM
CS(=O)(=O)c1ccc(C(=O)N[C@H]2CC[C@H](CCN3CCN(c4nccc5c4CCO5)CC3)CC2)s1 CHEMBL3642791 Ki 9.46 nM
Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2(C)O CHEMBL4065710 IC50 9.49 nM
O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1 CHEMBL3289948 Ki 9.5 nM
O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1 CHEMBL3289959 Ki 9.5 nM
O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccs1 CHEMBL3290000 Ki 9.5 nM
O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cnc2ccccn12 CHEMBL3290019 Ki 9.5 nM
Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2(C)O CHEMBL4082084 IC50 9.5 nM
CC(=O)c1c(OCCCN2CCN(c3ccc(Cl)cc3)CC2)ccc2c(C)cc(=O)oc12 CHEMBL4125847 Ki 9.5 nM
O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1 CHEMBL4248491 Kb 9.5 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)ccc34)CC2)CC1)c1ccc(N2CCOCC2)cc1 CHEMBL3942747 Ki 9.519 nM
O=C(N[C@H]1CC[C@H](CCN2CCC(c3cccc4c3OCO4)CC2)CC1)C1CCOCC1 CHEMBL3664860 Ki 9.52 nM
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5cc(F)ccc45)CC3)cc21 CHEMBL1257144 Ki 9.53 nM
O=C(c1ccc(F)cc1)C1CCN(CCc2ccc(F)cc2)CC1 CHEMBL78218 Ki 9.54 nM
O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(Cl)cc2s1 CHEMBL4763106 pKi 9.55 nM
CO[C@H](C)C(=O)N[C@H]1CC[C@H](CCN2CCC(c3cccc4c3OCO4)CC2)CC1 CHEMBL3664847 Ki 9.57 nM
O=C(c1ccccc1)C1CCN(CCc2ccccc2)CC1 CHEMBL19589 Ki 9.6 nM
O=S(=O)(c1ccc(/C=C/c2ccc(F)cc2)nc1)c1cccc(F)c1 CHEMBL394435 Ki 9.6 nM
CO[C@@H]1CC[C@@H](CC(=O)N[C@H]2CC[C@H](CCN3CCC(c4noc5cc(Cl)ccc45)CC3)CC2)OC1 CHEMBL3959647 Ki 9.637 nM
CCN1CCN(c2cc(-c3ccc(F)cc3)c3c(n2)CC[C@H](O)CCC3)CC1 CHEMBL360457 Ki 9.67 nM
CC(C)=CC(=O)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676898 Ki 9.68 nM
O=C(C[C@@H](O)C(F)(F)F)N[C@H]1CC[C@H](CCN2CCC(c3coc4ccccc34)CC2)CC1 CHEMBL3676880 Ki 9.69 nM
O=C(CC1COCCO1)N[C@H]1CC[C@H](CCN2CCN(c3nccc4c3CCO4)CC2)CC1 CHEMBL3642714 Ki 9.7 nM
NC[C@H]1C[C@]1(F)c1ccccc1 CHEMBL2094028 pEC50 9.772 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nccc4c3CCO4)CC2)CC1)C1(O)CCC1 CHEMBL3642799 Ki 9.8 nM
Cc1nc(C(=O)NCC(O)CN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccc2c(c1)OCCO2 CHEMBL3217167 IC50 9.86 nM
Cc1nc(C(=O)NCC(O)CN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccc2c(c1)OCCO2 CHEMBL1852666 IC50 9.86 nM
O=S(=O)(c1ccccc1F)N1CCC(CCc2ccc(F)cc2F)CC1 CHEMBL209415 Ki 9.9 nM
N#Cc1cc(F)ccc1/C=C/c1ccc(S(=O)(=O)c2ccccc2F)cn1 CHEMBL395458 Ki 9.9 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3nccc4c3CCO4)CC2)CC1)C1CCOC1 CHEMBL3642719 Ki 9.9 nM
C1=C(c2n[nH]c3ccccc23)CNCC1 CHEMBL5406172 EC50 9.9 nM
Cc1cccc(CNc2cc3c(cc2O)C(c2ccccc2)CN(C)CC3)c1 CHEMBL3325906 Ki 9.95 nM