Cn1ncc(C(=O)N2CCC(Nc3cc(=O)[nH]c4ccc(F)cc34)CC2)c1Cl CHEMBL3290767 IC50 -41900.0 nM
NCCc1c[nH]c2ccc(O)cc12 CHEMBL39 pEC50 0.07079 nM
COc1ccc(CC2NCCc3c2[nH]c2c(C)c(C)ccc32)c(Br)c1OC CHEMBL5270056 Kb 0.08 nM
COc1ccc(CC2NCCc3c2[nH]c2cc(C)c(C)cc32)cc1OC CHEMBL96480 Kb 0.08 nM
COc1ccc(CC2NCCc3c2[nH]c2cccc(C)c32)cc1OC CHEMBL5284094 Kb 0.08 nM
COc1ccc(CC2NCCc3c2[nH]c2c(C)cc(C)cc32)cc1OC CHEMBL96427 Kb 0.08 nM
NC(N)=NC(=O)c1ccc2c(c1)C(O)c1c(Cl)cccc1-2 CHEMBL3310115 Ki 0.11 nM
CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1 CHEMBL2028019 Ki 0.151 nM
CC(N)Cc1c2ccoc2c(Br)c2ccoc12 CHEMBL149024 Ki 0.19 nM
O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(Cc2ncc[nH]2)CC1 CHEMBL473185 IC50 0.2 nM
COc1ccc(CC2NCCc3c2[nH]c2ccc(C)cc32)c(Cl)c1OC CHEMBL95121 Ki 0.2 nM
CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 CHEMBL3187365 Ki 0.21 nM
CN(CCc1cn(C)c2cccc(O)c12)CC1CC1 CHEMBL5081637 IC50 0.245 nM
CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4c3c(cn4C)C[C@H]21 CHEMBL19215 Ki 0.281 nM
O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1 CHEMBL475407 IC50 0.3 nM
CC(C)c1cc(-c2ccc(F)c3ccccc23)nc(N)n1 CHEMBL473186 Ki 0.3 nM
Cc1c(C(=O)N2CCC(c3ncc[nH]3)CC2)n[nH]c1-c1ccc(Cl)cc1 CHEMBL5193649 Ki 0.3 nM
CC[C@@H](CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 CHEMBL1065 Ki 0.358 nM
O=C1CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2N1 CHEMBL1112 Ki 0.36 nM
NCCc1c[nH]c2ccc(O)cc12 CHEMBL535832 EC50 0.36 nM
COc1ccc(CC2NCCc3c2[nH]c2ccc(C)cc32)cc1OC CHEMBL5419724 IC50 0.37 nM
[2H]c1c([2H])c([2H])c([C@@H]2C[C@@H](N3CCNC(C)(C)C3)c3cc(Cl)ccc32)c([2H])c1[2H] CHEMBL5201983 Ki 0.39 nM
O=c1ccc2ccc(OCCCCN3CCN(c4cccc5sccc45)CC3)cc2[nH]1 CHEMBL2105760 pKi 0.3981 nM
O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1 CHEMBL475245 IC50 0.4 nM
NC(N)=NC(=O)c1ccc2c(c1)C(=O)c1ccccc1-2 CHEMBL3092758 Ki 0.4 nM
[2H]c1c([2H])c([2H])c([C@@H]2C[C@@H](N3CCN(C([2H])([2H])[2H])C(C)(C)C3)c3cc(Cl)ccc32)c([2H])c1[2H] CHEMBL5191141 Ki 0.4 nM
c1ccc2c(CC3NCCc4c3[nH]c3ccccc43)cccc2c1 CHEMBL329479 Kb 0.4 nM
NC(N)=NC(=O)c1ccc2c(c1)C1(CC1)c1ccccc1-2 CHEMBL3343668 Ki 0.51 nM
COC(OC)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 CHEMBL2323581 Ki 0.54 nM
COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC CHEMBL5207529 pEC50 0.5754 nM
O=S(=O)(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1 CHEMBL472990 IC50 0.6 nM
Clc1cccc(C2CCN(CCCCOc3ccc4scnc4c3)CC2)c1Cl CHEMBL2165137 Ki 0.6 nM
O=C1CCc2ccc(OCCCCN3CCCN(c4cccc(Cl)c4Cl)CC3)cc2N1 CHEMBL2165126 Ki 0.6 nM
Cc1cccc2c1C(O)c1cc(C(=O)N=C(N)N)ccc1-2 CHEMBL3310116 Ki 0.67 nM
CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O CHEMBL3310714 Ki 0.71 nM
CC[C@@H](CO)NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1 CHEMBL1201356 Ki 0.8 nM
Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O CHEMBL3310111 Ki 0.81 nM
N=C(N)NC(=O)c1ccc2c(c1)C(F)c1ccccc1-2 CHEMBL3310121 Ki 0.9 nM
NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(F)c1-2 CHEMBL3310112 Ki 0.91 nM
CN(C)CCCNC(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 CHEMBL2323580 Ki 0.97 nM
C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O CHEMBL196514 Log Ki 1.0 nM
Cc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1 CHEMBL272082 Ki 1.0 nM
CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 CHEMBL2323579 Ki 1.0 nM
N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O CHEMBL350221 EC50 1.0 nM
CC(C)n1nc2c(c1-c1ccc(Cl)cc1)CCNCC2 CHEMBL4784845 Ki 1.0 nM
COc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1 CHEMBL4752099 Ki 1.0 nM
CN(C)CCc1c[nH]c2cccc(O)c12 CHEMBL65547 IC50 1.07 nM
C[C@H](N)Cn1ccc2ccc3ncccc3c21 CHEMBL201930 EC50 1.1 nM
O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1 CHEMBL474408 IC50 1.1 nM
NC(N)=NC(=O)c1cccc2c1Cc1ccccc1-2 CHEMBL3092760 Ki 1.1 nM
Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O CHEMBL3310713 Ki 1.1 nM
O=C1CCc2ccc(OCCCCN3CCCN(c4cccc(Cl)c4Cl)CC3)nc2N1 CHEMBL2165119 Ki 1.1 nM
CCN(CC)C(=O)N[C@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1 CHEMBL157138 Ki 1.1 nM
CC(N)Cc1c2c(c(Br)c3c1OCC3)OCC2 CHEMBL101008 Ki 1.15 nM
C[C@@H](N)Cc1c2c(c(Br)c3c1OCC3)OCC2 CHEMBL305275 Ki 1.15 nM
O=C(c1ccc(-n2ccnc2)cc1)C1CC1 CHEMBL4533952 pEC50 1.259 nM
O=C(c1ccc(-n2cnc([N+](=O)[O-])c2)cc1)C1CC1 CHEMBL4460604 pEC50 1.259 nM
CCc1cccc(N2CCN(CC[C@H]3CC[C@H](NC(=O)c4ccnc5ccccc45)CC3)CC2)c1Cl CHEMBL5404054 Ki 1.27 nM
C[C@H]1CNCCc2ccc(Cl)cc21 CHEMBL360328 Ki 1.3 nM
COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1 CHEMBL5204071 EC50 1.3 nM
C=CCN1C[C@H](C(=O)N(CCCN(C)C)C(=O)NCC)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21 CHEMBL1201087 Ki 1.4 nM
COCCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1 CHEMBL5431103 Ki 1.47 nM
NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(Cl)c1-2 CHEMBL3310109 Ki 1.5 nM
CN1CCC(=C2c3ccccc3C=Cc3ccccc32)CC1 CHEMBL516 Ki 1.5 nM
O=C1Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)c(Cl)cc2N1 CHEMBL708 Log Ki 1.585 nM
O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1 CHEMBL131495 Log Ki 1.585 nM
C[C@H](N)Cn1ccc2cc(F)c(Cl)cc21 CHEMBL76781 Log EC50 1.585 nM
CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O CHEMBL3310113 Ki 1.6 nM
COc1cc(CC(C)N)c(OC)cc1I CHEMBL6616 Ki 1.6 nM
C[C@H](N)Cn1ncc2ccc(O)c(F)c21 CHEMBL197653 Ki 1.7 nM
NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cc(Cl)ccc1-2 CHEMBL3310110 Ki 1.7 nM
NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2 CHEMBL3343669 Ki 1.7 nM
COc1ccc(CCN(CCCc2ccccc2F)CCc2ccc3c(c2)OCO3)cc1OC CHEMBL3815112 Ki 1.7 nM
NC1=NC2(CCCCC2)NC(Nc2cccc(I)c2)=N1 CHEMBL4290245 Ki 1.7 nM
CCc1cccc(N2CCN(CC[C@H]3CC[C@H](NC(=O)COC)CC3)CC2)c1Cl CHEMBL5408223 Ki 1.71 nM
CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(F)cc3)=NN12 CHEMBL214554 IC50 1.8 nM
NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2 CHEMBL3092759 Ki 1.8 nM
NC(N)=NC(=O)c1ccc2c(c1)Cc1ccccc1-2 CHEMBL3092753 Ki 1.8 nM
NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2 CHEMBL3139188 Ki 1.8 nM
CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O CHEMBL3955519 Ki 1.8 nM
O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1 CHEMBL514934 IC50 1.9 nM
CC[C@@H](CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 CHEMBL1200938 Ki 1.9 nM
O=C(N[C@H]1CC[C@H](CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1)c1ccnc2ccccc12 CHEMBL5429826 Ki 1.99 nM
CN1C[C@@H](NS(=O)(=O)N(C)C)C[C@@H]2c3cccc4c3c(cn4C)C[C@H]21 CHEMBL12314 Log Ki 1.995 nM
Fc1ccc2c(c1Cl)N1CCNCC1CC2 CHEMBL3928388 pEC50 1.995 nM
CCc1cccc2c1C(=O)N1CCNC[C@H]1C2 CHEMBL2397890 Ki 2.0 nM
CN1CCC(=C2c3ccccc3CCc3sccc32)CC1 CHEMBL294951 Ki 2.0 nM
COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 CHEMBL3343667 Ki 2.0 nM
NC[C@H]1C[C@]1(F)c1cccc(F)c1 CHEMBL4466591 EC50 2.0 nM
Cc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1 CHEMBL4746737 Ki 2.0 nM
C[C@H](N)Cn1ccc2cc(Cl)c3ncccc3c21 CHEMBL201454 EC50 2.1 nM
NC(N)=NC(=O)c1ccc2c(c1)oc1ccccc12 CHEMBL3092754 Ki 2.1 nM
CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1 CHEMBL14022 Ki 2.2 nM
COc1cc(C[C@@H](C)N)c(OC)cc1I CHEMBL134519 Ki 2.2 nM
CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C=C2c3cccc4[nH]cc(c34)C[C@H]21 CHEMBL442 Ki 2.203 nM
O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1 CHEMBL475406 IC50 2.3 nM
COc1cc(CCNCc2ccccc2OC)c(OC)cc1I CHEMBL1908863 Ki 2.3 nM
CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1 CHEMBL2104523 AC50 2.3 nM
O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1 CHEMBL474404 IC50 2.4 nM
O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1 CHEMBL445809 IC50 2.4 nM
NC(N)=NC(=O)c1ccc2c(c1)Oc1ccccc1N2 CHEMBL3092757 Ki 2.4 nM
Cc1ccc(-c2nc(Cc3ccccc3)nc3c2CCNCC3)cc1 CHEMBL269974 Ki 2.5 nM
CCc1cc2c(ccc3cnn(C[C@H](C)N)c32)o1 CHEMBL407909 Ki 2.5 nM
O=C(c1cnc(-c2ccccc2)nc1)N1CCC(c2nc3ccccc3[nH]2)CC1 CHEMBL515422 IC50 2.5 nM
CN(C)CC/C=C1\c2ccc(Br)cc2COc2ccccc21 CHEMBL4287193 Ki 2.5 nM
Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O CHEMBL46 Ki 2.5 nM
Cn1ccc2cc(NC(=O)Nc3ccnc4ccccc34)ccc21 CHEMBL299498 Log Ki 2.512 nM
CC[C@H]1c2ccc3ccccc3c2OC[C@@]1(C)N CHEMBL4583909 pKi 2.512 nM
C[C@@H](CO)NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1 CHEMBL119443 Ki 2.634 nM
NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2 CHEMBL3343672 Ki 2.7 nM
C[C@H](N)CN1CCc2ccc3c(c21)CCO3 CHEMBL77880 EC50 3.0 nM
CCn1nc(-c2cccc3cccnc23)cc1-c1cccnn1 CHEMBL4100216 EC50 3.0 nM
O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1 CHEMBL4246655 Kb 3.0 nM
CN(C)CC/C=C1\c2ccc(Cl)cc2COc2ccccc21 CHEMBL4282729 Ki 3.0 nM
c1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1 CHEMBL4788327 Ki 3.0 nM
COc1ccc(CCN(CCCc2ccccc2Cl)CCc2ccc3c(c2)OCO3)cc1OC CHEMBL3813796 Ki 3.1 nM
COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1 CHEMBL5170784 EC50 3.1 nM
CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1 CHEMBL42 Log Ki 3.162 nM
CC1(C(=O)O)CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1 CHEMBL1277769 pKi 3.162 nM
Cc1c(Cl)ccc2c1N1[C@@H](CNC[C@H]1C)C2 CHEMBL190699 Ki 3.2 nM
COC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O CHEMBL3970041 Ki 3.2 nM
CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 CHEMBL4128926 IC50 3.2 nM
COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 CHEMBL3343665 Ki 3.3 nM
NCCCCNC(=O)COc1ccc(CCCn2ncc3c2nc(N)n2nc(-c4ccco4)nc32)cc1 CHEMBL4294350 Ki 3.36 nM
COc1ccc(-c2ccc(C(=O)N3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1 CHEMBL475778 IC50 3.4 nM
COc1ccc(CCN(CCCc2ccccc2Br)CCc2ccc3c(c2)OCO3)cc1OC CHEMBL3813726 Ki 3.4 nM
N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F CHEMBL513994 Ki 3.4 nM
NC[C@H]1C[C@@H]1c1cccc(F)c1 CHEMBL492926 EC50 3.6 nM
NC(N)=NC(=O)c1ccc2c(c1)Nc1ccccc1O2 CHEMBL3092756 Ki 3.6 nM
CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21 CHEMBL1732 Ki 3.7 nM
C[C@H](N)Cn1ncc2ccc(O)c(Cl)c21 CHEMBL373245 Ki 3.8 nM
Cc1cc2cc(NC(=O)Nc3ccnc4ccccc34)ccc2n1C CHEMBL300835 Log Ki 3.981 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(C)c(-c3cnccc3C)c1)CC2 CHEMBL14111 Log Ki 3.981 nM
CC(C)Oc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2 CHEMBL41389 Log Ki 3.981 nM
O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21 CHEMBL1224034 pEC50 3.981 nM
COc1cc(-c2ccccc2)ccc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1 CHEMBL472789 IC50 4.0 nM
Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21 CHEMBL594717 Kb 4.0 nM
Cc1ccc2c(c1Cl)C(=O)N[C@H]1CNC[C@H]21 CHEMBL2337501 Ki 4.0 nM
Fc1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1 CHEMBL4782005 Ki 4.0 nM
CSc1cc2c(cc1F)CCN2C[C@H](C)N CHEMBL76474 EC50 4.1 nM
COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1OC CHEMBL3735261 Ki 4.1 nM
CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O CHEMBL1255837 Ki 4.201 nM
Cn1ccc2cc3c(cc21)CCN3C(=O)Nc1cccnc1 CHEMBL297784 Ki 4.3 nM
CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 CHEMBL3310123 Ki 4.3 nM
CC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 CHEMBL3310122 Ki 4.4 nM
CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O CHEMBL3976121 Ki 4.4 nM
O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1 CHEMBL4292326 Ki 4.5 nM
COc1cccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1 CHEMBL3735911 Ki 4.6 nM
CN1CCN2c3ccccc3Cc3ccccc3C2C1 CHEMBL6437 Ki 4.642 nM
COc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1 CHEMBL401509 Ki 4.8 nM
NCC1CC1c1ccccc1Br CHEMBL492916 EC50 4.8 nM
CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 CHEMBL3343666 Ki 4.8 nM
Cc1cc([C@H]2C[C@@H]2CN)ccc1F CHEMBL474633 EC50 4.9 nM
CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1 CHEMBL282199 Ki 5.0 nM
CC(C)n1nc2c(c1-c1ccc(C(F)(F)F)cc1)CCNCC2 CHEMBL4791646 Ki 5.0 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(C)c(-c3cccnc3)c1)CC2 CHEMBL14606 Log Ki 5.012 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3)c1Cl)CC2 CHEMBL14458 Log Ki 5.012 nM
CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 CHEMBL3217984 pKi 5.012 nM
NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2 CHEMBL3343670 Ki 5.1 nM
NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2 CHEMBL3343673 Ki 5.1 nM
CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]c(Br)c(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 CHEMBL493 Ki 5.292 nM
C[C@H](N)Cc1c[nH]c2ccc3c(c12)CCCO3 CHEMBL133455 Ki 5.3 nM
C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 CHEMBL2391541 pEC50 5.495 nM
NC[C@H]1C[C@@H]1c1cccc(O)c1 CHEMBL510383 EC50 5.5 nM
Brc1ccc2[nH]nc(C3=CCCNC3)c2c1 CHEMBL5424175 pEC50 5.623 nM
NC1CC1c1c[nH]c2ccc(F)cc12 CHEMBL147656 Ki 5.7 nM
CCCCn1cc(CCN(C)C)c2c(O)cccc21 CHEMBL198124 Ki 5.8 nM
COc1ccccc1CCCN(CCc1ccc(OC)c(OC)c1)CCc1ccc2c(c1)OCO2 CHEMBL3736149 Ki 5.8 nM
NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1 CHEMBL3770342 Ki 5.8 nM
CCc1cc(Cl)c(OC)c(N2CCN(CC[C@H]3CC[C@H](NC(=O)CCOC)CC3)CC2)c1 CHEMBL5424897 Ki 5.8 nM
COc1ccc2[nH]cc(CCN(C)C)c2c1 CHEMBL7257 EC50 5.87 nM
C[C@H](N)Cn1ncc2ccc(O)c(I)c21 CHEMBL201132 Ki 6.0 nM
CCOc1nc(-c2ccccc2)ncc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1 CHEMBL514453 IC50 6.0 nM
O=C1Cc2c(ccc3c2OC[C@H](CNCC2CCc4[nH]c5ccc(F)cc5c4C2)O3)N1 CHEMBL569251 Ki 6.0 nM
O=C1c2c(cccc2C2CC2)C[C@@H]2CNCCN12 CHEMBL2397891 Ki 6.0 nM
CNc1cc(OC)c(C(=O)NC2CCN(Cc3ccccc3)C2C)cc1Cl CHEMBL20734 AC50 6.0 nM
CCc1cc(Cl)c(OC)c(N2CCN(CC[C@H]3CC[C@H](NC(=O)NC)CC3)CC2)c1 CHEMBL5437660 Ki 6.2 nM
COCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O CHEMBL3310118 Ki 6.3 nM
NC1=NC2(CCCCC2)NC(Nc2cccc(Cl)c2)=N1 CHEMBL4293638 Ki 6.3 nM
Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3cncn3C)nc1)CC2 CHEMBL55969 Log Ki 6.31 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3cnccc3C)c1)CC2 CHEMBL14864 Log Ki 6.31 nM
COc1cc(Cl)c(Cl)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O CHEMBL91221 Log Ki 6.31 nM
Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1 CHEMBL715 Log Ki 6.31 nM
CC1(C)Cc2cccc(Cl)c2N2CCNCC21 CHEMBL3895972 pKi 6.31 nM
C[C@H](N)CN1CCc2ccc(Cl)cc21 CHEMBL76307 EC50 6.5 nM
O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1 CHEMBL473234 IC50 6.5 nM
Clc1ccc2c(c1)C(N1CCNCC1)=Nc1ccccc1O2 CHEMBL1113 Ki 6.569 nM
NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(CO)c1-2 CHEMBL3310117 Ki 6.6 nM
O=c1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c(-c2ccc(F)cc2)[nH]1 CHEMBL3634745 IC50 6.7 nM
COc1ccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1 CHEMBL3736207 Ki 6.8 nM
CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 CHEMBL1385840 Ki 6.855 nM
CC(C)[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12 CHEMBL2113264 Ki 7.0 nM
Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN CHEMBL474634 EC50 7.0 nM
COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2 CHEMBL3959919 Ki 7.0 nM
C=CCN1C[C@H](C(=O)N(CCCN2CCOCC2)C(=O)NCC)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21 CHEMBL2323578 Ki 7.1 nM
CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1 CHEMBL3770106 Ki 7.2 nM
COc1ccccc1N1CCN(CC[C@@H](C(=O)N2CCCCCC2)c2ccccc2)CC1 CHEMBL5193178 Ki 7.2 nM
C[C@H](N)CN1CCc2cc(F)c(Cl)cc21 CHEMBL80366 EC50 7.3 nM
CCc1cc(Cl)c(OC)c(N2CCN(CC[C@H]3CC[C@H](NC(=O)N(C)C)CC3)CC2)c1 CHEMBL5409134 Ki 7.3 nM
COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 CHEMBL296419 Ki 7.487 nM
COc1ccc2cnn(C[C@H](C)N)c2c1 CHEMBL199775 Ki 7.5 nM
COc1ccc2[nH]cc(CC(C)N)c2c1 CHEMBL31115 Ki 7.8 nM
C[C@H](Cc1cccc(F)c1)Oc1nc(N2CCNC[C@H]2C)ncc1F CHEMBL494948 Ki 7.9 nM
COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 CHEMBL325109 AC50 7.9 nM
Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(OCc3ccccn3)c(C)c1)CC2 CHEMBL55914 Log Ki 7.943 nM
Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3ccncc3)nc1)CC2 CHEMBL291949 Log Ki 7.943 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3)c1)CC2 CHEMBL14255 Log Ki 7.943 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(F)c(C)c(-c3cccnc3)c1)CC2 CHEMBL280465 Log Ki 7.943 nM
CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3)c1)CC2 CHEMBL428879 Log Ki 7.943 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc3c(c(-c4cccnc4)c1)OCC3)CC2 CHEMBL417082 Log Ki 7.943 nM
COc1ccc2c(c1Cl)N1CCCNC[C@H]1CC2 CHEMBL3934644 pEC50 7.943 nM
CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21 CHEMBL223468 EC50 8.0 nM
O=C1c2c(Cl)cccc2C[C@@H]2CNCCN12 CHEMBL2397893 Ki 8.0 nM
CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(Br)c2)C1 CHEMBL3402673 Ki 8.0 nM
C[C@H](N)Cn1ncc2ccc(O)cc21 CHEMBL371300 Ki 8.1 nM
CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 CHEMBL1403281 Ki 8.217 nM
COc1ccc2[nH]cc(C(C)CN)c2c1 CHEMBL149564 Ki 8.3 nM
CN(C)CCc1c[nH]c2cccc(F)c12 CHEMBL197646 Ki 8.39 nM
Cc1cccc([C@H]2C[C@@H]2CN)c1C CHEMBL475642 EC50 8.4 nM
CCCN1C[C@H](CSC)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21 CHEMBL531 AC50 8.4 nM
Cc1cccc2c1C(=O)NC1CNCCN21 CHEMBL590078 Ki 8.6 nM
Cc1c(O)ccc2cnn(C[C@H](C)N)c12 CHEMBL200104 Ki 8.7 nM
O=C1c2cc(Cl)ccc2C[C@@H]2CNCCN12 CHEMBL2397877 EC50 9.0 nM
NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2 CHEMBL3343671 Ki 9.1 nM
CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)c(F)c3)CC2)nc2ccccc12 CHEMBL182150 IC50 9.66 nM
COc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1 CHEMBL1214961 Ki 9.7 nM
CCN1CCC(COc2nc3ccsc3n3cccc23)CC1 CHEMBL511312 pIC50 9.772 nM
O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21 CHEMBL2337490 EC50 9.9 nM
Clc1cccc(COc2cncc(N3CCNCC3)n2)c1 CHEMBL4743049 Ki 9.943 nM