CC(N)Cc1c2ccoc2c(Br)c2ccoc12 CHEMBL149024 Ki 0.02 nM
CCCc1ccnc2c1CC[C@@H]1CNCCN21 CHEMBL4765074 pEC50 0.0631 nM
NCCc1c[nH]c2ccc(O)cc12 CHEMBL39 EC50 0.09 nM
Clc1ccccc1OC1CCc2ccc(N3CCNCC3)nc21 CHEMBL595195 EC50 0.1 nM
Clc1ccccc1O[C@H]1CCc2ccc(N3CCNCC3)nc21 CHEMBL609306 EC50 0.1 nM
c1cc(CC2CCC2)c2c(n1)N1CCNC[C@H]1CC2 CHEMBL4213447 pEC50 0.1 nM
Clc1cccc(COc2cncc(N3CCNCC3)n2)c1 CHEMBL494947 EC50 0.11 nM
c1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1 CHEMBL4213379 EC50 0.116 nM
CN(C)CCc1cn(CC2CC2)c2cccc(O)c12 CHEMBL5078731 IC50 0.12 nM
N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O CHEMBL350221 EC50 0.18 nM
Fc1cccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)c1 CHEMBL4208452 EC50 0.19 nM
COc1ccc(-c2ccccc2)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O CHEMBL93862 Log Ki 0.1995 nM
CCCc1cccc2c1CCC1CNCCN21 CHEMBL3947276 pEC50 0.1995 nM
CCCc1cccc2c1CC[C@@H]1CNCCN21 CHEMBL4776557 pEC50 0.1995 nM
NCCc1cn2c3c(cccc13)CCC2 CHEMBL171774 EC50 0.2 nM
Cc1cc2c(ccc3cnn(C[C@H](C)N)c32)o1 CHEMBL408579 Ki 0.2 nM
C[C@H](N)Cn1ncc2ccc3occc3c21 CHEMBL261476 Ki 0.2 nM
O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1 CHEMBL12713 Ki 0.2 nM
CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1 CHEMBL193639 Ki 0.21 nM
NCCc1cn2c3c(cc(Cl)cc13)SCC2 CHEMBL172159 EC50 0.23 nM
COc1cc(Cl)c(Cl)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O CHEMBL91221 Log Ki 0.2512 nM
CC(N)Cc1c2c(c(Br)c3c1OCC3)OCC2 CHEMBL101008 Ki 0.3 nM
C[C@@H](N)Cc1c2c(c(Br)c3c1OCC3)OCC2 CHEMBL305275 Ki 0.3 nM
Cc1c(Cl)ccc2c1N1[C@@H](CNC[C@H]1C)C2 CHEMBL190699 Ki 0.3 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(C)c(-c3cnccc3C)c1)CC2 CHEMBL14111 Log Ki 0.3162 nM
COc1ccc(N2CC=C(c3ccc(C)cc3)C2=O)cc1OCCN1CCCCC1 CHEMBL377174 Log Ki 0.3162 nM
CCSc1cccc2c1CCC1CNCCN21 CHEMBL3979806 pEC50 0.3162 nM
c1csc(Cc2cccc3c2CCC2CNCCN32)c1 CHEMBL3959570 pKi 0.3162 nM
NCCc1c[nH]c2ccc(O)cc12 CHEMBL535832 EC50 0.32 nM
Clc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1 CHEMBL5187275 pEC50 0.3236 nM
Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2 CHEMBL14563 IC50 0.33 nM
CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4c3c(cn4C)C[C@H]21 CHEMBL19215 Ki 0.347 nM
CSc1ccc2c(c1)C(N1CCN(C)CC1)Cc1ccccc1S2 CHEMBL93240 EC50 0.38 nM
Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(OCc3ccccn3)c(C)c1)CC2 CHEMBL55914 Log Ki 0.3981 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3cnccc3C)c1)CC2 CHEMBL14864 Log Ki 0.3981 nM
CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2 CHEMBL54560 Log Ki 0.3981 nM
COc1ccc2c(c1)-c1c(ccn1CC(C)N)C2(C)C CHEMBL318639 Log Ki 0.3981 nM
COc1ccc(N2Cc3cc(F)cc(C(F)(F)F)c3C2=O)cc1OCCN1CCC(C)CC1 CHEMBL234739 Log Ki 0.3981 nM
Fc1ccc2c(c1Cc1ccccc1)CCC1CNCCN21 CHEMBL3956394 pKi 0.3981 nM
CC(C)Cc1ccnc2c1CC[C@@H]1CNCCN21 CHEMBL4777852 pEC50 0.3981 nM
Cc1c2n(c3c(C)c(Cl)ccc13)C(C)NCC2 CHEMBL2260569 EC50 0.4 nM
COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC CHEMBL5207529 pEC50 0.4677 nM
Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1 CHEMBL605405 pKi 0.4786 nM
O=C(Nc1ccc(Oc2cccnc2Cl)nc1)c1c[nH]c2ccccc12 CHEMBL516452 IC50 0.5 nM
Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)nc1)CC2 CHEMBL54719 Log Ki 0.5012 nM
Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3cnccn3)nc1)CC2 CHEMBL54707 Log Ki 0.5012 nM
COc1ccc(NC(=O)N2CCc3cc(OC)c(C(F)(F)F)cc32)cc1-c1cccnc1 CHEMBL276571 Log Ki 0.5012 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc3c(c(-c4cccnc4)c1)OCC3)CC2 CHEMBL417082 Log Ki 0.5012 nM
Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cnccc3Cl)nc1)CC2 CHEMBL55207 Log Ki 0.5012 nM
c1ccc(Cc2cncc3c2CC[C@@H]2CNCCN32)cc1 CHEMBL4778570 pKi 0.5012 nM
COc1nn(C[C@H](C)N)c2c1ccc1occc12 CHEMBL262092 Ki 0.51 nM
O=C(Nc1ccc2c(c1)CCC(CN1CCCC1)=C2)c1ccc(-c2ccc(F)cc2)cc1 CHEMBL1818901 IC50 0.53 nM
O=C1Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)c(Cl)cc2N1 CHEMBL708 Ki 0.55 nM
CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 CHEMBL64249 Ki 0.57 nM
NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12 CHEMBL4779260 EC50 0.59 nM
C[C@@H]1CNCCN1c1ccc2c(n1)[C@@H](Oc1ccccc1Cl)CC2 CHEMBL594251 Ki 0.6 nM
Clc1cccc(C2CCN(CCCCOc3ccc4scnc4c3)CC2)c1Cl CHEMBL2165137 Ki 0.6 nM
O=C1CCc2ccc(OCCCCN3CCCN(c4cccc(Cl)c4Cl)CC3)cc2N1 CHEMBL2165126 Ki 0.6 nM
COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C(F)(F)F)cc1 CHEMBL88402 Ki 0.6 nM
CC1CN2CCNCc3ccc(Br)c1c32 CHEMBL4639090 Ki 0.6 nM
CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 CHEMBL3187365 AC50 0.6 nM
CN1CCN2c3ccccc3Cc3ccccc3C2C1 CHEMBL6437 Ki 0.606 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2 CHEMBL14374 Log Ki 0.631 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3ccncc3)c1)CC2 CHEMBL14863 Log Ki 0.631 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(F)c(C)c(-c3cccnc3)c1)CC2 CHEMBL280465 Log Ki 0.631 nM
CCc1cc(NC(=O)N2CCc3cc(OC)c(C(F)(F)F)cc32)cc(-c2cccnc2)c1 CHEMBL416896 Log Ki 0.631 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cnccc3C)c1)CC2 CHEMBL273345 Log Ki 0.631 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Cl)c(-c3cnccc3C)c1)CC2 CHEMBL14362 Log Ki 0.631 nM
Cc1cc2c(cc1Cl)N(C(=O)Nc1cnc(Oc3cccnc3C)c(Cl)c1)CC2 CHEMBL301012 Log Ki 0.631 nM
COc1cc2c(cc1OCCN1CCCCC1)N(C(=O)/C=C/c1ccccc1Cl)CC2 CHEMBL197630 pKi 0.631 nM
c1cc(CC2CCC2)c2c(c1)N1CCNCC1CC2 CHEMBL3912721 pKi 0.631 nM
c1ccc(Cc2cccc3c2CCC2CNCCN32)cc1 CHEMBL3919795 pKi 0.631 nM
CN(C)C[C@@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1 CHEMBL363581 Ki 0.65 nM
Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2 CHEMBL14460 IC50 0.7 nM
C[C@H](Cc1cccc(F)c1)Oc1nc(N2CCNC[C@H]2C)ncc1F CHEMBL494948 Ki 0.7 nM
Cc1nc2sccn2c(=O)c1CCN1CCC(=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1 CHEMBL267777 Ki 0.71 nM
O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21 CHEMBL1224034 pEC50 0.7244 nM
NC[C@H]1C[C@@H]1c1ccccc1Br CHEMBL467736 EC50 0.78 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3cccnc3)c1)CC2 CHEMBL14345 Log Ki 0.7943 nM
Cc1cc2c(cc1Br)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2 CHEMBL59584 Log Ki 0.7943 nM
COc1ccc(N2CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1 CHEMBL197807 pKi 0.7943 nM
COc1ccc(N2CC=C(c3cccc(F)c3)C2=O)cc1OCCN1CCCCC1 CHEMBL213839 Log Ki 0.7943 nM
COc1ccc(N2CC=C(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1 CHEMBL213987 Log Ki 0.7943 nM
COc1ccc(N2Cc3cccc(Br)c3C2=O)cc1OCCN1CCC(C)CC1 CHEMBL234109 Log Ki 0.7943 nM
Fc1ccc2c(c1)N1CCNCC1CC2 CHEMBL3967107 pEC50 0.7943 nM
c1cc(Cc2ccc3c(c2)OCO3)c2c(c1)N1CCNCC1CC2 CHEMBL3935339 pKi 0.7943 nM
CC[C@@H](CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 CHEMBL1200938 pKi 0.7943 nM
COc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)c(O)c1 CHEMBL5198213 pEC50 0.7943 nM
C[C@@H]1CNC[C@H]2Cc3ccc(Br)nc3N21 CHEMBL203393 Ki 0.8 nM
Cc1ccc2c3c1C(C)CN3CCNC2 CHEMBL4646618 EC50 0.8 nM
CC1CN2CCNCc3ccc(Cl)c1c32 CHEMBL4634942 Ki 0.8 nM
FC(F)(F)CC1CN2CCNCc3ccc(Br)c1c32 CHEMBL4646572 Ki 0.8 nM
CCc1cc2c(ccc3cnn(C[C@H](C)N)c32)o1 CHEMBL407909 Ki 0.89 nM
CCc1cc2c(ccc3cnn(C[C@@H](C)N)c32)o1 CHEMBL575849 Ki 0.89 nM
COc1cc(OC2CCC(C)(C)CC2)c(F)cc1CNC(=O)[C@@H]1CCCN1 CHEMBL1091105 Ki 0.9 nM
CC1(C)CN2CCNCc3ccc(Br)c1c32 CHEMBL4636977 Ki 0.9 nM
CCn1cc(CCN(C)C)c2c(O)cccc21 CHEMBL5077004 IC50 0.9 nM
CN1C[C@@H](NS(=O)(=O)N(C)C)C[C@@H]2c3cccc4c3c(cn4C)C[C@H]21 CHEMBL12314 Ki 0.92 nM
CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1 CHEMBL329566 Ki 0.93 nM
COc1ccc(Cl)c(Cl)c1C1CC1CN CHEMBL3769454 EC50 0.95 nM
CN(C)C[C@@H]1C[C@@H]2c3ccccc3Cc3ccccc3N2O1 CHEMBL328573 Ki 1.0 nM
O=S1(=O)c2cccc3cccc(c23)N1CCCN1CCN(c2ccc(F)cc2)CC1 CHEMBL83894 Ki 1.0 nM
COc1ccc2[nH]cc(C(C)CN)c2c1 CHEMBL149564 Ki 1.0 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3)c1)CC2 CHEMBL14255 Log Ki 1.0 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(C)c(-c3cccnc3)c1)CC2 CHEMBL14606 Log Ki 1.0 nM
Clc1cc2c(cc1Cl)N1CCNCC1CN2 CHEMBL58009 Ki 1.0 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(F)cc(-c3cccnc3)c1)CC2 CHEMBL14276 Log Ki 1.0 nM
Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c2cc(Cl)c(C)c3Cl)cn1 CHEMBL55079 Log Ki 1.0 nM
Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cnccc3C)nc1)CC2 CHEMBL55331 Log Ki 1.0 nM
COc1ccc2c(c1)-c1c(ccn1C[C@H](C)N)C2 CHEMBL2114265 Log Ki 1.0 nM
C[C@H](N)Cn1ccc2cc(F)c(F)cc21 CHEMBL40726 Log Ki 1.0 nM
COc1ccc2c(c1)-c1c(ccn1CC(C)N)C2 CHEMBL414163 Log Ki 1.0 nM
COc1ccc(N2CCN(c3cc(F)cc(F)c3)C2=O)cc1OCCN1CCCCC1 CHEMBL372339 pKi 1.0 nM
C[C@H](N)Cn1ncc2ccc(O)c(F)c21 CHEMBL197653 Ki 1.0 nM
COc1ccc(N2Cc3ccc(Cl)c(Cl)c3C2=O)cc1OCCN1CCC(C)CC1 CHEMBL234533 Log Ki 1.0 nM
C[C@@H](N)Cn1ccc2cc(F)c(Cl)cc21 CHEMBL574985 Ki 1.0 nM
C[C@@H]1CNCCN1c1ccc2c(n1)[C@@H](OCc1cc(F)ccc1F)CC2 CHEMBL595645 EC50 1.0 nM
Clc1nc(N2CCNCC2)nc2sccc12 CHEMBL596327 Ki 1.0 nM
CC1(C)CCC(Oc2cc(F)c(CNC(=O)[C@@H]3CCCN3)cc2F)CC1 CHEMBL1091106 EC50 1.0 nM
O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21 CHEMBL2337490 EC50 1.0 nM
COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1 CHEMBL5204071 EC50 1.02 nM
CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1 CHEMBL315772 Log IC50 1.047 nM
CC[C@@H](CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 CHEMBL1065 Ki 1.093 nM
Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21 CHEMBL2337494 EC50 1.1 nM
[2H]c1c([2H])c([2H])c([C@@H]2C[C@@H](N3CCNC(C)(C)C3)c3cc(Cl)ccc32)c([2H])c1[2H] CHEMBL5201983 Ki 1.1 nM
c1cc(C2CCC2)c2c(n1)N1CCNC[C@H]1CC2 CHEMBL4204710 EC50 1.14 nM
CN(C)CC1CC2c3ccccc3Cc3ccc(F)cc3N2O1 CHEMBL84931 pIC50 1.148 nM
CCCc1cncc2c1CC[C@@H]1CNCCN21 CHEMBL4218374 EC50 1.17 nM
C[C@H](N)Cn1ncc2ccc(O)c(Cl)c21 CHEMBL373245 Ki 1.2 nM
Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1 CHEMBL592752 Ki 1.2 nM
Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3ccncc3)nc1)CC2 CHEMBL291949 Log Ki 1.259 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3)nc1)CC2 CHEMBL14726 Log Ki 1.259 nM
Cc1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(Oc2cccnc2C)nc1 CHEMBL292228 Log Ki 1.259 nM
Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cccnc3Cl)nc1)CC2 CHEMBL294030 Log Ki 1.259 nM
Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c2cc(C(F)(F)F)c2c3CCO2)cn1 CHEMBL55292 Log Ki 1.259 nM
Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Br)c(C(F)(F)F)cc32)cn1 CHEMBL53152 Log Ki 1.259 nM
C[C@H](N)Cn1ccc2c(Cl)c(F)ccc21 CHEMBL2114266 Log Ki 1.259 nM
C[C@H](N)Cn1ccc2cc(F)c(Cl)cc21 CHEMBL76781 Log Ki 1.259 nM
C[C@@H](N)Cn1ccc2c(Cl)c(F)ccc21 CHEMBL2115254 Log Ki 1.259 nM
COc1ccc(N2CCN(c3ccccc3)C2=O)cc1OCCN1CCCCC1 CHEMBL383800 pKi 1.259 nM
COc1ccc(N2CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN(C)C CHEMBL196953 pKi 1.259 nM
COc1ccc(N2CC=C(c3ccc(Br)cc3)C2=O)cc1OCCN1CCCCC1 CHEMBL210053 Log Ki 1.259 nM
COc1ccc(N2Cc3cc(Cl)c(C)c(Cl)c3C2=O)cc1OCCN1CCC(C)CC1 CHEMBL395298 Log Ki 1.259 nM
COc1ccc(N2C(=O)c3c(Cl)cccc3C2C)cc1OCCN1CCC(C)CC1 CHEMBL395059 Log Ki 1.259 nM
FC(F)(F)CCc1ccnc2c1CC[C@@H]1CNCCN21 CHEMBL4206126 pEC50 1.259 nM
CN1CCC(=C2c3ccccc3C=Cc3ccccc32)CC1 CHEMBL516 Ki 1.278 nM
Cc1ccc2c(c1)N1[C@@H](CNC[C@H]1C)C2 CHEMBL190124 Ki 1.3 nM
NCC1CC1c1ccccc1Br CHEMBL492916 EC50 1.3 nM
C[C@@H]1CNC[C@H]2Cc3ccc(C(F)(F)F)cc3N21 CHEMBL361079 Ki 1.4 nM
CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21 CHEMBL223468 EC50 1.4 nM
C[C@H](N)Cn1ncc2ccc3sccc3c21 CHEMBL406851 Ki 1.4 nM
Fc1ccc(F)c(CO[C@H]2CCc3ccc(N4CCNCC4)nc32)c1 CHEMBL594469 EC50 1.4 nM
CN1CCC(=C2c3ccccc3CCc3sccc32)CC1 CHEMBL294951 Ki 1.4 nM
CC1(C)CN2CCNCc3ccc(Cl)c1c32 CHEMBL4635105 Ki 1.4 nM
Cc1c(Cl)ccc2c1N1CCNC[C@H]1C2 CHEMBL187739 Ki 1.5 nM
CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1 CHEMBL366164 Ki 1.5 nM
COc1ccc2cnn(C[C@H](C)N)c2c1 CHEMBL199775 Ki 1.5 nM
Clc1ccccc1O[C@H]1CCCc2ccc(N3CCNCC3)nc21 CHEMBL595194 Ki 1.5 nM
Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21 CHEMBL594717 Ki 1.5 nM
CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCN(C)CC2)cc1 CHEMBL2111101 Ki 1.5 nM
[2H]c1c([2H])c([2H])c([C@@H]2C[C@@H](N3CCN(C([2H])([2H])[2H])C(C)(C)C3)c3cc(Cl)ccc32)c([2H])c1[2H] CHEMBL5191141 Ki 1.5 nM
CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3)c1)CC2 CHEMBL428879 Log Ki 1.585 nM
Cc1ccc2c(c1Br)CCN2C(=O)Nc1ccc(Oc2cccnc2C)nc1 CHEMBL54775 Log Ki 1.585 nM
Cc1cc2c(cc1Cl)N(C(=O)Nc1cnc(Oc3cccnc3C)c(C)c1)CC2 CHEMBL55964 Log Ki 1.585 nM
Cc1cc2c(cc1F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2 CHEMBL56336 Log Ki 1.585 nM
Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(Oc3cccnc3C)c(Cl)c1)CC2 CHEMBL56508 Log Ki 1.585 nM
CCCc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(C)c(Cl)cc32)cn1 CHEMBL55472 Log Ki 1.585 nM
COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C(C)C)cc1 CHEMBL91454 Log Ki 1.585 nM
COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 CHEMBL90565 Log Ki 1.585 nM
COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCN1CCCCC1 CHEMBL198330 pKi 1.585 nM
COc1ccc(N2CC=C(c3ccc(C)cc3)C2=O)cc1OCCN1CCC(C)CC1 CHEMBL386332 Log Ki 1.585 nM
COc1ccc(N2Cc3sc4ccccc4c3C2=O)cc1OCCN1CCC(C)CC1 CHEMBL388882 Log Ki 1.585 nM
COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCC(C)CC1 CHEMBL234532 Log Ki 1.585 nM
COc1ccc(N2Cc3cccc(C(F)(F)F)c3C2=O)cc1OCCN1CCC(C)CC1 CHEMBL396748 Log Ki 1.585 nM
COc1ccc(N2Cc3cccc(Cl)c3C2=O)cc1OCCN1CCC(C)CC1 CHEMBL396747 Log Ki 1.585 nM
Cc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1 CHEMBL605081 pKi 1.585 nM
C[C@H](N)Cn1ccc2ccc3ncccc3c21 CHEMBL201930 Ki 1.6 nM
C[C@@H]1CNC[C@H]2Cc3ccc(Cl)nc3N21 CHEMBL203230 Ki 1.6 nM
O=C(Nc1ccc(Oc2cccnc2)nc1)c1c[nH]c2ccccc12 CHEMBL479952 IC50 1.6 nM
Cn1ncc(Br)c1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCCN1CCCC1 CHEMBL569475 Ki 1.6 nM
COc1ccc2occc2c1[C@H]1C[C@@H]1CN CHEMBL4751981 EC50 1.6 nM
Cc1ccc2c(c1C)N1[C@@H](CNC[C@H]1C)C2 CHEMBL188033 Ki 1.7 nM
COc1cc(OCC2CCCCC2)c(F)cc1CNC(=O)[C@@H]1CCCN1 CHEMBL1093699 Ki 1.7 nM
COc1cc(CCNCc2ccccc2O[11CH3])c(OC)cc1Br CHEMBL5203398 Ki 1.7 nM
O=C1NC2CCNCCN2c2cccc(Cl)c21 CHEMBL590483 EC50 1.8 nM
Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2 CHEMBL85 IC50 1.81 nM
COc1cc(CC(C)N)c(OC)cc1I CHEMBL6616 Ki 1.82 nM
C[C@H]1CNCCc2ccc(Cl)cc21 CHEMBL360328 pEC50 1.82 nM
NC1CC1c1c[nH]c2ccc(F)cc12 CHEMBL147656 Ki 1.9 nM
Cc1c(Cl)ccc2c1N1[C@H](CNC[C@H]1C)C2 CHEMBL191054 Ki 1.9 nM
Cc1ccc2c(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c[nH]c2c1 CHEMBL519103 IC50 1.9 nM
Oc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1 CHEMBL5200026 EC50 1.9 nM
c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1 CHEMBL2393243 IC50 1.98 nM
Clc1ccc2c(c1)C(N1CCNCC1)=Nc1ccccc1O2 CHEMBL1113 Ki 1.984 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(Br)cc(-c3cccnc3)c1)CC2 CHEMBL14368 Log Ki 1.995 nM
Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Cl)c(Cl)cc32)cn1 CHEMBL301784 Log Ki 1.995 nM
Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cncnc3C)nc1)CC2 CHEMBL299938 Log Ki 1.995 nM
Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(Oc3cccnc3C)cn1)CC2 CHEMBL53308 Log Ki 1.995 nM
CSc1cc2c(cc1Br)N(C(=O)Nc1cccnc1)CC2 CHEMBL41940 Log Ki 1.995 nM
CSc1cc2c(cc1I)N(C(=O)Nc1cccnc1)CC2 CHEMBL288129 Log Ki 1.995 nM
CCc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(C)c(Cl)cc32)cn1 CHEMBL55792 Log Ki 1.995 nM
Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cccnc3C)nn1)CC2 CHEMBL52308 Log Ki 1.995 nM
CC(N)Cn1ccc2cc(Cl)c(F)cc21 CHEMBL313856 Log Ki 1.995 nM
COc1ccc(N2CCN(c3ccc(C)c(C(F)(F)F)c3)C2=O)cc1OCCN1CCCCC1 CHEMBL198171 pKi 1.995 nM
COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCC(C)(C)CC1 CHEMBL234494 Log Ki 1.995 nM
COc1ccc(N2Cc3c(F)c(F)cc(Cl)c3C2=O)cc1OCCN1CCC(C)CC1 CHEMBL234531 Log Ki 1.995 nM
CCOc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Br)cnn1C CHEMBL599193 pKi 1.995 nM
Cc1cccc2c1CCC1CNCCN21 CHEMBL3930174 pEC50 1.995 nM
Cc1ccnc2c1CC[C@@H]1CNCCN21 CHEMBL4747291 pEC50 1.995 nM
FC(F)(F)CCc1cccc2c1CC[C@@H]1CNCCN21 CHEMBL4757718 pKi 1.995 nM
COc1cc2c(cc1I)C(C)CNCC2 CHEMBL179378 EC50 2.0 nM
[3H]C([3H])([3H])Oc1cc(I)c(OC)cc1CCNCc1ccccc1OC([3H])([3H])[3H] CHEMBL482496 Ki 2.0 nM
Cc1cccc2c1C(=O)NC1CCNCCN21 CHEMBL590580 EC50 2.0 nM
CCn1nc(-c2cccc3cccnc23)cc1-c1cccnn1 CHEMBL4100216 EC50 2.0 nM
CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(F)(F)F)cc2)CC1 CHEMBL5205903 Ki 2.0 nM
C[C@@H]1CNC[C@H]2Cc3ccccc3N21 CHEMBL2112055 Ki 2.2 nM
Cc1ccc2c(c1Cl)C(=O)N[C@H]1CNC[C@H]21 CHEMBL2337501 EC50 2.2 nM
C[C@H](N)Cn1ccc2cc(F)c(Cl)cc21 CHEMBL2331803 EC50 2.2 nM
CCO[C@@H](C)c1ccc2c(n1)N1[C@@H](CNC[C@H]1C)C2 CHEMBL206394 Ki 2.3 nM
Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1 CHEMBL2393245 IC50 2.3 nM
CC(N)Cc1ccc2ccccc2c1 CHEMBL471839 EC50 2.3 nM
Cn1ccc2cc3c(cc21)CCN3C(=O)Nc1cccnc1 CHEMBL297784 Kb 2.3 nM
COc1ccccc1CNC[C@H]1C[C@@H]1c1cc(F)ccc1OCCF CHEMBL4091672 pEC50 2.399 nM
CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1 CHEMBL435301 Ki 2.4 nM
C[C@H](N)Cn1ccc2cc(Cl)c3ncccc3c21 CHEMBL201454 Ki 2.4 nM
Clc1c(Br)ccc2c1CCNCC2 CHEMBL259480 Ki 2.4 nM
C[C@@H]1CN(c2ccc(C(F)(F)F)c3ccoc23)CCN1 CHEMBL573131 Ki 2.4 nM
CCc1nn(C[C@H](C)N)c2c1ccc1occc12 CHEMBL261045 Ki 2.5 nM
Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3ccccn3)nc1)CC2 CHEMBL293937 Log Ki 2.512 nM
Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)cc1)CC2 CHEMBL55335 Log Ki 2.512 nM
CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2 CHEMBL276140 Log Ki 2.512 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3c(C)ccnc3C)c1)CC2 CHEMBL274066 Log Ki 2.512 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(-c3ccccc3)cc(-c3cccnc3)c1)CC2 CHEMBL280297 Log Ki 2.512 nM
CCc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2 CHEMBL52919 Log Ki 2.512 nM
CSc1c(Cl)cc2c(c1Cl)CCN2C(=O)Nc1cccnc1 CHEMBL417713 Log Ki 2.512 nM
COc1ccc(N2CC=C(c3cccc(Cl)c3)C2=O)cc1OCCN1CCCCC1 CHEMBL212270 Log Ki 2.512 nM
COc1ccc(N2Cc3c(c4cc(F)ccc4n3C)C2=O)cc1OCCN1CCC(C)CC1 CHEMBL232254 Log Ki 2.512 nM
COc1ccc(N2Cc3c(c4cccc(F)c4n3C)C2=O)cc1OCCN1CCC(C)CC1 CHEMBL395098 Log Ki 2.512 nM
COc1ccc(N2Cc3c(c4cc(Cl)ccc4n3C)C2=O)cc1OCCN1CCCCC1 CHEMBL234948 Log Ki 2.512 nM
COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCCCCC1 CHEMBL395072 Log Ki 2.512 nM
COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCCC(C)C1 CHEMBL234492 Log Ki 2.512 nM
COc1ccc(N2Cc3cc(Cl)c(Cl)c(C)c3C2=O)cc1OCCN1CCC(C)CC1 CHEMBL234738 Log Ki 2.512 nM
COc1ccc(N2Cc3cccc(C)c3C2=O)cc1OCCN1CCC(C)CC1 CHEMBL234006 Log Ki 2.512 nM
COc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Br)cnn1C(C)C CHEMBL604586 pKi 2.512 nM
COc1cc(CCNCc2cccc3ccoc23)c(OC)cc1Br CHEMBL3589579 pKi 2.512 nM
c1ccc2c(c1)CC[C@@H]1CNCCN21 CHEMBL3946277 pEC50 2.512 nM
COc1ccc2c(c1)-c1c(cnn1C[C@H](C)N)C2(C)C CHEMBL4086240 pKi 2.512 nM
COc1ccc2c(c1)-c1c(cnn1C[C@H](C)N)C2 CHEMBL4092042 pKi 2.512 nM
CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN CHEMBL4756903 pEC50 2.57 nM
Cc1cccc2c1N1[C@@H](CNC[C@H]1C)C2 CHEMBL190584 Ki 2.6 nM
O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21 CHEMBL2337493 EC50 2.6 nM
Fc1ccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)cc1 CHEMBL2393247 EC50 2.6 nM
Cc1nc2ccccn2c(=O)c1CCN1CCN(c2cccc3sccc23)CC1 CHEMBL4094825 IC50 2.69 nM
CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2 CHEMBL4790652 pEC50 2.692 nM
CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1 CHEMBL4748110 pEC50 2.692 nM
CC(N)Cc1cn(C)c2ccc3c(c12)CCCO3 CHEMBL131736 Ki 2.7 nM
O=C(c1ccc(F)cc1)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1 CHEMBL51 IC50 2.7 nM
Cc1ccc2c(n1)N1[C@@H](CNC[C@H]1C)C2 CHEMBL206845 Ki 2.7 nM
CCc1cc2c(ccc3c(CC)nn(C[C@H](C)N)c32)o1 CHEMBL403927 Ki 2.7 nM
CN(C)CCc1cn(CCF)c2cccc(O)c12 CHEMBL5071818 IC50 2.7 nM
CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc21 CHEMBL71 Ki 2.742 nM
NC[C@H]1C[C@]1(F)c1cccc(F)c1 CHEMBL4466591 pEC50 2.754 nM
Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1 CHEMBL715 Ki 2.8 nM
CC1CN2CCNCc3cc(Cl)c(Cl)c1c32 CHEMBL4632473 Ki 2.8 nM
CCN(C)CCc1cn(C)c2cccc(O)c12 CHEMBL5085055 IC50 2.8 nM
CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1 CHEMBL42 Log Ki 2.884 nM
CN(C)CCOC1=Cc2ccccc2Sc2ccc(Cl)cc21 CHEMBL285802 Ki 2.9 nM
Cn1nccc1-c1cc(NC(=O)Nc2cccc(C(F)(F)F)c2)ccc1OCCN1CCCCC1 CHEMBL565322 Ki 2.9 nM
CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 CHEMBL303313 Ki 2.9 nM
O=C1Nc2cc(Cl)c(Cl)cc2N2CCNC[C@H]12 CHEMBL303516 Ki 3.0 nM
C[C@@H]1CNCCc2ccc(Cl)c(Cl)c21 CHEMBL181076 EC50 3.0 nM
CC1CNCCc2cc(O)c(Br)cc21 CHEMBL178313 EC50 3.0 nM
COc1cc2c(cc1Br)[C@@H](C)CNCC2 CHEMBL180867 EC50 3.0 nM
C[C@H](N)Cn1ncc2ccc(O)cc21 CHEMBL371300 Ki 3.0 nM
NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl CHEMBL451232 EC50 3.0 nM
Cn1ncc(Cl)c1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCCN1CCCC1 CHEMBL571915 Ki 3.0 nM
Fc1cccc(O[C@H]2CCc3ccc(N4CCNCC4)nc32)c1 CHEMBL608116 Ki 3.0 nM
Clc1ccc(-c2ccc(-c3cc4c5c(c3)[C@@H]3CNC[C@@H]3N5CCCS4)cc2)c(Cl)c1 CHEMBL2260567 EC50 3.0 nM
COc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2 CHEMBL2397878 EC50 3.0 nM
C[C@@H]1CNC[C@H]2Cc3ccccc3C(=O)N21 CHEMBL2397887 EC50 3.0 nM
c1cc2c3c(c1)[C@H]1CCC[C@H]1CN3CCNC2 CHEMBL2110670 Ki 3.0 nM
C1=CC2CNCCN3C[C@@H]4CCC[C@@H]4C(=C1)C23 CHEMBL4634785 Ki 3.0 nM
Cc1ccc2c(c1)N1OC(CN(C)C)CC1c1ccccc1C2 CHEMBL85735 pIC50 3.02 nM
CC(=O)NCc1ccc2c(c1)[C@H](N1CCN(C)CC1)Cc1ccccc1S2 CHEMBL1259173 Ki 3.1 nM
O=C(Nc1ccc2c(c1)OCC(CN1CCCC1)=C2)c1ccc(-c2ccc(F)cc2)cc1 CHEMBL2031574 IC50 3.1 nM
Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(CCc3ccccn3)nc1)CC2 CHEMBL55784 Log Ki 3.162 nM
CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3ccncc3)c1)CC2 CHEMBL14841 Log Ki 3.162 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(C(C)(C)C)c(-c3cccnc3)c1)CC2 CHEMBL446942 Log Ki 3.162 nM
O=C(Nc1cccnc1)N1CCc2cc(I)c(Cl)cc21 CHEMBL43929 Log Ki 3.162 nM
CCSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2 CHEMBL289436 Log Ki 3.162 nM
Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nn1)CC2 CHEMBL58765 Log Ki 3.162 nM
Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c2ccc(Cl)c3Cl)cn1 CHEMBL56050 Log Ki 3.162 nM
Cc1cc2c(cc1I)N(C(=O)Nc1cccnc1)CC2 CHEMBL296090 Log Ki 3.162 nM
Cc1cc2c(cc1Cl)N(C(=O)Nc1cnc(Oc3cccnc3C)nc1)CC2 CHEMBL53113 Log Ki 3.162 nM
Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Br)ccc32)cn1 CHEMBL54769 Log Ki 3.162 nM
Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(I)ccc32)cn1 CHEMBL433060 Log Ki 3.162 nM
CC(C)Oc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2 CHEMBL41389 Log Ki 3.162 nM
COc1ccc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)c1 CHEMBL310656 Log Ki 3.162 nM
CC(N)Cn1ccc2c1-c1cc(F)ccc1C2 CHEMBL93154 Log Ki 3.162 nM
Cc1ccc2c(c1)-c1c(ccn1CC(C)N)C2(C)C CHEMBL328761 Log Ki 3.162 nM
COc1ccc(N2CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCOCC1 CHEMBL198007 pKi 3.162 nM
COc1ccc(N2CC=C(c3ccc(F)cc3)C2=O)cc1OCCN1CCC(C)CC1 CHEMBL215864 Log Ki 3.162 nM
COc1ccc(N2CC=C(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCC(C)CC1 CHEMBL209573 Log Ki 3.162 nM
COc1ccc(N2Cc3c(c4cc(Cl)ccc4n3C)C2=O)cc1OCCN1CCC(C)CC1 CHEMBL232046 Log Ki 3.162 nM
COc1ccc(N2Cc3sc4ccccc4c3C2=O)cc1OCCN1CCCCC1 CHEMBL233442 Log Ki 3.162 nM
COc1ccc(N2Cc3cc(C)cc(C)c3C2=O)cc1OCCN1CCC(C)CC1 CHEMBL396527 Log Ki 3.162 nM
COc1ccc(NC(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1-c1c(Br)cnn1C CHEMBL602873 pKi 3.162 nM
COc1cc(F)c(F)cc1C1CC1CN CHEMBL3770753 pEC50 3.162 nM
COc1ccc(F)c(Cl)c1C1CC1CN CHEMBL3770225 pEC50 3.162 nM
Fc1ccc2c(c1)CCC1CNCCN21 CHEMBL3955996 pEC50 3.162 nM
c1cc(C2CCC2)c2c(c1)N1CCNCC1CC2 CHEMBL3982618 pEC50 3.162 nM
CN(C)CCC=C1c2ccccc2CCc2ccccc21 CHEMBL629 Ki 3.168 nM
CSc1cc2c(cc1F)CCN2C[C@H](C)N CHEMBL76474 Ki 3.2 nM
CN(C)C[C@@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1 CHEMBL329268 Ki 3.25 nM
NC[C@H]1C[C@@H]1c1cccc(F)c1 CHEMBL492926 EC50 3.3 nM
NC[C@H]1C[C@@H]1c1cccc(O)c1 CHEMBL510383 EC50 3.3 nM
NCC1c2ccccc2Cc2cc(Br)ccc21 CHEMBL85882 Ki 3.3 nM
O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21 CHEMBL2337500 EC50 3.3 nM
CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21 CHEMBL2337492 EC50 3.3 nM
COc1cc(CCNCc2cccc3c2OCC3)c(OC)cc1Br CHEMBL3589582 pKi 3.388 nM
C[C@H](N)Cc1c[nH]c2ccc3c(c12)CCCO3 CHEMBL133455 Ki 3.4 nM
NC[C@H]1C[C@@H]1c1cc(F)ccc1OCCF CHEMBL3416067 EC50 3.4 nM
Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN CHEMBL474634 EC50 3.5 nM
Cc1c(O)ccc2cnn(C[C@H](C)N)c12 CHEMBL200104 Ki 3.6 nM
C[C@@H]1CNC[C@H]2Cc3ccc(COCC4CC4)nc3N21 CHEMBL203013 Ki 3.6 nM
CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1 CHEMBL364270 Ki 3.7 nM
C[C@@H]1CNC[C@H]2Cc3ccc(C#N)cc3N21 CHEMBL187888 Ki 3.8 nM
O=C(NCCCCN1CCN(c2cccc3ccccc23)CC1)c1cnc2ccccc2c1 CHEMBL3597635 Ki 3.8 nM
COc1ccc(Cl)c(F)c1C1CC1CN CHEMBL3769987 EC50 3.8 nM
CN(C)CC1CC2c3ccccc3Oc3ccc(Cl)cc3N2O1 CHEMBL310183 pIC50 3.802 nM
Cc1cccc2c1Cc1ccccc1C1CC(CN(C)C)ON21 CHEMBL82635 pIC50 3.89 nM
Cc1ccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cc1NC(=O)c1ccc(-c2ccccc2)cc1 CHEMBL458002 pKi 3.89 nM
CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O CHEMBL3955519 Ki 3.9 nM
Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3cncn3C)nc1)CC2 CHEMBL55969 Log Ki 3.981 nM
Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ncccc3C)nc1)CC2 CHEMBL54484 Log Ki 3.981 nM
Cc1ncccc1Oc1ccc(NC(=O)N2CCc3ccc(Cl)cc32)cn1 CHEMBL299726 Log Ki 3.981 nM
Cc1c(Cl)cc2c(c1Cl)CCN2C(=O)Nc1cccnc1 CHEMBL42681 Log Ki 3.981 nM
CSc1cc2c(cc1C(F)(F)C(F)(F)F)N(C(=O)Nc1cccnc1)CC2 CHEMBL44015 Log Ki 3.981 nM
Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(C(F)(F)F)ccc32)cn1 CHEMBL54610 Log Ki 3.981 nM
Cc1cc2c(cc1Br)N(C(=O)Nc1cccnc1)CC2 CHEMBL43916 Log Ki 3.981 nM
COc1ccc(Cl)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O CHEMBL90346 Log Ki 3.981 nM
COc1ccc2c(c1)-c1c(ccn1C[C@@H](C)N)C2 CHEMBL3350300 Log Ki 3.981 nM
C[C@@H](N)Cn1ccc2cc(F)c(F)cc21 CHEMBL2115252 Log Ki 3.981 nM
CC(N)Cn1ccc2c1-c1cc(Cl)ccc1C2 CHEMBL91855 Log Ki 3.981 nM
CC(N)Cn1ccc2ccc(F)cc21 CHEMBL92656 Log Ki 3.981 nM
CC(N)Cn1ccc2cc(Br)ccc21 CHEMBL276673 Log Ki 3.981 nM
CC(N)Cn1ccc2c1-c1cc(Br)ccc1C2 CHEMBL320145 Log Ki 3.981 nM
COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCN(C)C CHEMBL197170 pKi 3.981 nM
COc1ccc(N2CC=C(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCC1 CHEMBL211850 Log Ki 3.981 nM
COc1ccc(N2CC=C(c3ccc(Br)cc3)C2=O)cc1OCCN1CCC(C)CC1 CHEMBL209432 Log Ki 3.981 nM
COc1ccc(N2CC=C(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCC(C)(C)CC1 CHEMBL376962 Log Ki 3.981 nM
COc1ccc(N2Cc3c(c4ccc(Cl)cc4n3C)C2=O)cc1OCCN1CCC(C)CC1 CHEMBL232045 Log Ki 3.981 nM
COc1ccc(N2Cc3cccc(Cl)c3C2=O)cc1OCCN1CCCCC1 CHEMBL396505 Log Ki 3.981 nM
C[C@@H]1CNCCc2ccc(Cl)c(F)c21 CHEMBL253807 Log EC50 3.981 nM
C[C@H]1CNCCc2cc(Cl)c(Cl)cc21 CHEMBL253591 Log EC50 3.981 nM
CC1CNCCc2cc(Cl)c(Cl)cc21 CHEMBL178366 Log EC50 3.981 nM
COc1ccc(NC(=O)Nc2ccc(Br)cc2)cc1-c1c(Br)cnn1C CHEMBL599225 pKi 3.981 nM
COc1ccc(NC(=O)Nc2ccc(C(F)(F)F)cc2)cc1-c1c(Br)cnn1C CHEMBL606191 pKi 3.981 nM
COc1ccc(NC(=O)Nc2ccc(F)cc2)cc1-c1c(Br)cnn1C(C)C CHEMBL606622 pKi 3.981 nM
COc1cc2c(cc1Cl)CC[C@@H]1CNCCCN21 CHEMBL3895184 pEC50 3.981 nM
COc1cc(C[C@@H](C)N)c(OC)cc1I CHEMBL134519 Ki 4.0 nM
O=C1Nc2cc(Cl)c(Cl)cc2N2CCNCC12 CHEMBL301466 Ki 4.0 nM
C[C@H](N)Cn1ccc2ccc(F)cc21 CHEMBL80226 Ki 4.0 nM
COc1cc2c(cc1C(F)(F)F)C(C)CNCC2 CHEMBL179915 EC50 4.0 nM
C[C@H](N)Cn1ncc2ccc(Cl)c(Cl)c21 CHEMBL264172 Ki 4.0 nM
Clc1cccc(COc2nc(N3CCNCC3)nc3sccc23)c1 CHEMBL595646 Ki 4.0 nM
O=C(NCc1ccc(-c2ccc(Cl)cc2)cc1F)N1CCNCC1 CHEMBL1090397 Ki 4.0 nM
CC(C)N(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1 CHEMBL1222134 IC50 4.0 nM
CCC1CC(=O)c2c(N3CCN(C)CC3)cccc2N1S(=O)(=O)c1ccc2ccccc2c1 CHEMBL1642126 IC50 4.0 nM
CCOc1ccc2c(c1)c(C[C@H](C)N)c1n2CCC1 CHEMBL2260565 EC50 4.0 nM
CCc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2 CHEMBL2397897 EC50 4.0 nM
CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(Br)c2)C1 CHEMBL3402673 Ki 4.0 nM
CCc1cccc(N2CCN(C)CC2)c1Cl CHEMBL4469777 Ki 4.0 nM
COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccccc3)cc3c1[C@H](C2)N(C)CC3 CHEMBL5204813 Ki 4.0 nM
COC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O CHEMBL3970041 Ki 4.1 nM
O=C(c1ccc(-n2cnc([N+](=O)[O-])c2)cc1)C1CC1 CHEMBL4460604 pEC50 4.169 nM
C=CCOc1ccc(F)cc1[C@H]1C[C@@H]1CN CHEMBL3416063 EC50 4.2 nM
Cc1ccc2c3c1C(C)(C)CN3CCNC2 CHEMBL4638879 Ki 4.2 nM
O=C(c1ccc(-n2ccnc2)cc1)C1CC1 CHEMBL4533952 pEC50 4.266 nM
c1cc2c3c(c1)c1c(n3CCO2)CCNCC1 CHEMBL76494 Ki 4.3 nM
CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1 CHEMBL194659 Ki 4.3 nM
CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21 CHEMBL2337106 EC50 4.3 nM
Oc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21 CHEMBL5179588 EC50 4.3 nM
CCCCn1cc(CCN(C)C)c2c(O)cccc21 CHEMBL198124 Ki 4.4 nM
O=C(NCc1ccc(C2CCCCC2)cc1)[C@@H]1CCCN1 CHEMBL1092029 Ki 4.4 nM
C[C@H](N)CN1CCc2ccc3c(c21)CCO3 CHEMBL77880 EC50 4.5 nM
Cc1ccc2[nH]cc(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c2c1 CHEMBL480127 IC50 4.5 nM
c1ccc(Cc2ncc3c(n2)CCNCC3)cc1 CHEMBL1770373 EC50 4.5 nM
CN(C)CC1CC2c3ccccc3Cc3cc(F)ccc3N2O1 CHEMBL84081 pIC50 4.677 nM
COc1cccc(CNCCc2cc(OC)c(Br)cc2OC)c1 CHEMBL3589597 pKi 4.677 nM
NC[C@H]1C[C@]1(F)c1ccccc1 CHEMBL2094028 pEC50 4.677 nM
Clc1c2n(c3ccccc13)CCNCC2 CHEMBL77234 Ki 4.7 nM
c1ccc2c(c1)cc1n2CCNCC1 CHEMBL312258 Ki 4.8 nM
C[C@H](N)Cn1ncc2ccc(O)c(I)c21 CHEMBL201132 Ki 4.8 nM
Cc1cccc([C@H]2C[C@@H]2CN)c1 CHEMBL445747 EC50 4.8 nM
COc1cccc(Cc2c(N)nc(SCCN3CCN(Cc4cccc(C(F)(F)F)c4)CC3)nc2N)c1 CHEMBL107860 Ki 4.9 nM
Fc1ccc2c([C@@H]3CNCC[C@H]3F)c(C3CCCCC3)[nH]c2c1 CHEMBL507898 Ki 5.0 nM
COc1cc2c(cc1Br)C(C)CNCC2 CHEMBL180815 EC50 5.0 nM
COc1cc2c(cc1Br)[C@H](C)CNCC2 CHEMBL182184 EC50 5.0 nM
C[C@H]1c2c(ccc(Cl)c2Cl)[C@H]2CNC[C@H]21 CHEMBL441531 Ki 5.0 nM
COc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O CHEMBL373531 EC50 5.0 nM
CCc1cc2c(ccc3c(C)nn(C[C@H](C)N)c32)o1 CHEMBL403926 Ki 5.0 nM
Fc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1 CHEMBL1643676 EC50 5.0 nM
Cc1cccc2c1C(=O)N1CCNC[C@H]1C2 CHEMBL2397889 EC50 5.0 nM
CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(-c3ccccc3)c2)C1 CHEMBL3402682 Ki 5.0 nM
CCn1nc(-c2cccc3cccnc23)cc1-c1ccc(N)nn1 CHEMBL4081247 EC50 5.0 nM
Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(COc3ccccn3)nc1)CC2 CHEMBL55344 Log Ki 5.012 nM
Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3nccn3C)nc1)CC2 CHEMBL55597 Log Ki 5.012 nM
Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3nccs3)nc1)CC2 CHEMBL301409 Log Ki 5.012 nM
Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)nn1)CC2 CHEMBL432879 Log Ki 5.012 nM
CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1 CHEMBL263881 Log Ki 5.012 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3ccccc3)c1)CC2 CHEMBL14652 Log Ki 5.012 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(-c3ccncc3)cc1)CC2 CHEMBL274692 Log Ki 5.012 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(-c3cccnc3)nc1)CC2 CHEMBL277111 Log Ki 5.012 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Cl)c(-c3cccnc3)c1)CC2 CHEMBL14469 Log Ki 5.012 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3C)c1)CC2 CHEMBL14076 Log Ki 5.012 nM
CCc1cc2c(cc1Cl)N(C(=O)Nc1cccnc1)CC2 CHEMBL43808 Log Ki 5.012 nM
Cc1ncccc1Oc1ccc(NC(=O)N2CCc3ccc(C(F)(F)F)cc32)cn1 CHEMBL291510 Log Ki 5.012 nM
COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(Cl)cc1 CHEMBL88894 Log Ki 5.012 nM
CC(N)Cn1ccc2c1-c1cc(F)ccc1C2(C)C CHEMBL94272 Log Ki 5.012 nM
CN(C)CC1CC2c3ccccc3Cc3c(F)cccc3N2O1 CHEMBL315834 pIC50 5.012 nM
COc1ccc(N2CC=C(c3cccc(C(F)(F)F)c3)C2=O)cc1OCCN1CCCCC1 CHEMBL212064 Log Ki 5.012 nM
COc1ccc(N2CC=C(c3cccc(Cl)c3)C2=O)cc1OCCN1CCC(C)CC1 CHEMBL212886 Log Ki 5.012 nM
COc1ccc(N2CCC(C)(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1 CHEMBL214398 Log Ki 5.012 nM
COc1ccc(N2CCC(C)(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCC(C)CC1 CHEMBL212769 Log Ki 5.012 nM
COc1ccc(C2=CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1 CHEMBL210007 Log Ki 5.012 nM
COc1ccc(N2CC=C(c3ccc(OC)c(OCCN4CCCCC4)c3)C2=O)cc1Cl CHEMBL387022 Log Ki 5.012 nM
CC(C)Nc1cc2c(cc1NS(=O)(=O)c1ccc(-c3ccc(Cl)cc3)cc1)CCN(C)CC2 CHEMBL231350 Log Ki 5.012 nM
COc1ccc(N2C(=O)c3c(n(C)c4ccccc34)C2O)cc1OCCN1CCC(C)CC1 CHEMBL233440 Log Ki 5.012 nM
COc1ccc(N2Cc3c(c4ccc(Cl)cc4n3C)C2=O)cc1OCCN1CCCCC1 CHEMBL397259 Log Ki 5.012 nM
COc1ccc(N2Cc3cc(Cl)c(Cl)cc3C2=O)cc1OCCN1CCC(C)CC1 CHEMBL395297 Log Ki 5.012 nM
O=C(c1ccc(N2CCN(Cc3ccccc3)CC2)cc1)C1CC1 CHEMBL4567689 pEC50 5.012 nM
Clc1ccnc2c1CC[C@@H]1CNCCN21 CHEMBL4750216 pEC50 5.012 nM
COCc1ccnc2c1CC[C@@H]1CNCCN21 CHEMBL4785566 pEC50 5.012 nM
N#Cc1ccc2c(c1Cl)CCNCC2 CHEMBL406585 Ki 5.1 nM
NC[C@H]1C[C@@H]1c1ccccc1Cl CHEMBL443128 EC50 5.1 nM
NC[C@H]1C[C@@H]1c1ccccc1 CHEMBL452719 EC50 5.2 nM
Fc1cccc(F)c1-c1cc2c3c(c1)[C@H]1CNCC[C@H]1N3CCCS2 CHEMBL573354 Ki 5.2 nM
C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN CHEMBL4790992 EC50 5.3 nM
NC[C@H]1C[C@@H]1c1ccc(F)cc1 CHEMBL493130 EC50 5.4 nM
Cn1nccc1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCCN1CCC1 CHEMBL568104 Ki 5.4 nM
c1cc2nc3c(c(N4CCC4)n2n1)CCNCC3 CHEMBL1643670 EC50 5.4 nM
CCc1cccc(N2CCNCC2)c1Cl CHEMBL4441358 Ki 5.4 nM
CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3 CHEMBL133868 Ki 5.5 nM
Nc1nc(SCCN2CCN(Cc3ccccc3Cl)CC2)nc(N)c1Cc1ccccc1O CHEMBL104308 Ki 5.5 nM
COc1ccccc1Cc1c(N)nc(SCCN2CCN(Cc3cccc(C(F)(F)F)c3)CC2)nc1N CHEMBL107847 Ki 5.5 nM
CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1 CHEMBL198463 Ki 5.5 nM
NCC1CC2c3ccccc3Cc3ccccc3N2O1 CHEMBL83731 pIC50 5.623 nM
CC1CCc2cc(F)cc3c(CCN)cn1c23 CHEMBL355474 EC50 5.7 nM
CSc1ccc2c(c1)N(C[C@H](C)N)CC2 CHEMBL451543 Ki 5.7 nM
CC(C)(C)Cc1ccnc2c1CC[C@@H]1CNCCN21 CHEMBL4217787 EC50 5.84 nM
COc1cc(Br)c2c3c1C[C@H](N)C[C@@H]3CO2 CHEMBL445106 Ki 5.96 nM
CC1CNCCc2ccc(Cl)c(Cl)c21 CHEMBL178231 EC50 6.0 nM
CN(C)C[C@@H]1C[C@H]2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1 CHEMBL365101 Ki 6.0 nM
COc1cc2c(cc1Cl)[C@H](C)[C@@H]1CNC[C@H]21 CHEMBL425777 EC50 6.0 nM
Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21 CHEMBL374562 EC50 6.0 nM
O=S(=O)(c1ccccc1)c1ccc2c(c1)CCNCC2 CHEMBL521805 Ki 6.0 nM
Cc1cc([C@H]2C[C@@H]2CN)ccc1F CHEMBL474633 EC50 6.0 nM
O=C(Nc1ccc(OCc2ccccn2)nc1)c1c[nH]c2ccccc12 CHEMBL479763 IC50 6.0 nM
CN1CCN(c2cccc(N(CC3CC3)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1 CHEMBL1221449 IC50 6.0 nM
COc1ccc(C)c2c1C[C@@H]1CNCCN1C2=O CHEMBL2397912 EC50 6.0 nM
O=C(NCCCCN1CCN(c2cccc3ccccc23)CC1)c1ccccc1 CHEMBL3358512 Ki 6.0 nM
Cc1nc(-c2cccc3ccccc23)sc1C(=O)N1CCC(CO)CC1 CHEMBL4081863 EC50 6.0 nM
Cn1nc(-c2cccc3ccccc23)cc1C(=O)N1CCC(CO)CC1 CHEMBL4075267 EC50 6.0 nM
CCOC(=O)Cc1nn(CNC(=O)CCCN2CCN(c3ccc(C)c(C)c3)CC2)c(=O)c2cc(F)ccc12 CHEMBL4644910 IC50 6.0 nM
FC(F)(F)c1ccc2c3c1CCN3CCNC2 CHEMBL4647417 Ki 6.0 nM
O=C1CC(=O)N(c2ccnc(-c3noc(=S)[nH]3)c2)c2ccc3ccccc3c2N1 CHEMBL5179436 Ki 6.0 nM
c1ccc2c3c([nH]c2c1)CCNCC3 CHEMBL310620 Ki 6.1 nM
CN(C)CC1CC2c3cc(F)ccc3Cc3ccc(F)cc3N2O1 CHEMBL314107 pIC50 6.166 nM
CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN CHEMBL4759181 pEC50 6.166 nM
Nc1nc(SCCN2CCN(Cc3cccc(C(F)(F)F)c3)CC2)nc(N)c1Cc1ccccc1O CHEMBL107912 Ki 6.2 nM
NCCc1c[nH]c2ccc3c(c12)CCCO3 CHEMBL27173 Ki 6.3 nM
Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(F)c(Cl)cc32)cn1 CHEMBL299530 Ki 6.3 nM
Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Cl)ccc32)cn1 CHEMBL59097 Ki 6.3 nM
Cc1cc2c(cc1Cl)N(C(=O)Nc1cccnc1)CC2 CHEMBL42024 Ki 6.3 nM
CC(N)Cn1ccc2cc(F)ccc21 CHEMBL96883 Ki 6.3 nM
Cc1cccc(COc2ccc(NC(=O)N3CCc4cc(C)c(C(F)(F)F)cc43)cn2)n1 CHEMBL53939 Log Ki 6.31 nM
O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2cc(C(F)(F)F)ccc21 CHEMBL300618 Log Ki 6.31 nM
CSc1cc2c(cc1Cl)N(C(=O)Nc1cccnc1)CC2 CHEMBL265991 Log Ki 6.31 nM
COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3ccc(F)cc3)c1)CC2 CHEMBL14401 Log Ki 6.31 nM
O=C(Nc1cccnc1)N1CCc2cc(Cl)c(C(F)(F)F)cc21 CHEMBL296189 Log Ki 6.31 nM
CCCSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2 CHEMBL41792 Log Ki 6.31 nM
CCOc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2 CHEMBL41510 Log Ki 6.31 nM
COc1cc(Cl)ccc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O CHEMBL90470 Log Ki 6.31 nM
Cc1cccc2c1ccn2CC(C)N CHEMBL317677 Log Ki 6.31 nM
Cc1ccc2c(c1)Cc1ccccc1N1OC(CN(C)C)CC21 CHEMBL85155 pIC50 6.31 nM
COc1ccc(-n2ccn(-c3cccc(F)c3)c2=O)cc1OCCN1CCCCC1 CHEMBL198712 pKi 6.31 nM
COc1ccc(N2CC=C(c3ccc(F)cc3)C2=O)cc1OCCN1CCCCC1 CHEMBL213272 Log Ki 6.31 nM
COc1ccc(N2CC=C(c3ccc(Cl)cc3)C2=O)cc1OCCN1CCC(C)CC1 CHEMBL386431 Log Ki 6.31 nM
COc1ccc(N2CC=C(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCOCC1 CHEMBL211267 Log Ki 6.31 nM
COc1ccc(N2CC=C(c3ccc(OC)c(OCCN4CCCCC4)c3)C2=O)cc1F CHEMBL380020 Log Ki 6.31 nM
COc1ccc(C2=CCN(c3cccc(F)c3)C2=O)cc1OCCN1CCCCC1 CHEMBL438963 Log Ki 6.31 nM
COc1ccc(N2Cc3c(c4cc(Cl)c(Cl)cc4n3C)C2=O)cc1OCCN1CCCCC1 CHEMBL234947 Log Ki 6.31 nM
COc1ccc(N2Cc3c(c4ccccc4n3C)C2=O)cc1OCCN1CCCCC1 CHEMBL535626 Log Ki 6.31 nM
COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1[C@H](C)CCC[C@@H]1C CHEMBL397709 Log Ki 6.31 nM
COc1ccc(N2Cc3c(F)ccc(C(F)(F)F)c3C2=O)cc1OCCN1CCC(C)CC1 CHEMBL234315 Log Ki 6.31 nM
CC1CNCCc2cc(F)c(Cl)cc21 CHEMBL360492 Log EC50 6.31 nM
COc1cc2c(cc1Cl)[C@H](C)CNCC2 CHEMBL400600 Log EC50 6.31 nM
CC1CNCCc2ccc(C(F)(F)F)cc21 CHEMBL178124 Log EC50 6.31 nM
O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1 CHEMBL1276948 pKi 6.31 nM
COc1cc(CCNCc2cccc(OC)c2O)c(OC)cc1Br CHEMBL3589596 pKi 6.31 nM
Fc1ccc2c(c1Cl)N1CCNCC1CC2 CHEMBL3928388 pEC50 6.31 nM
c1cc(C2CC2)c2c(n1)N1CCNC[C@H]1CC2 CHEMBL4778104 pEC50 6.31 nM
CCSc1cc2c(cc1F)CCN2C[C@H](C)N CHEMBL80731 Ki 6.4 nM
CCCCCCCCCCC[C@@H]1CCN[C@H](C(=O)N[C@@H]([C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)[C@H](C)Cl)C1 CHEMBL4560254 Ki 6.4 nM
CC(CN1c2ccccc2Sc2ccccc21)N(C)C CHEMBL643 Ki 6.477 nM
COc1ccc(NC(=O)N2CCN(c3ccc(-c4ccccc4)cc3)CC2)cc1N1CCN(C)CC1 CHEMBL197408 Ki 6.5 nM
Cc1ccc2c(c1)N1CCNCCC1NC2=O CHEMBL590531 Ki 6.5 nM
CC[C@@H](CO)NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1 CHEMBL1201356 Ki 6.558 nM
CC(N)Cc1c[nH]c2ccc(O)cc12 CHEMBL275854 Ki 6.6 nM
COc1ccc2occc2c1[C@@H]1C[C@H]1CN CHEMBL4739937 EC50 6.6 nM
CN(C)CC1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1 CHEMBL92667 Ki 6.7 nM
Cc1c2n(c3ccccc13)CCNCC2 CHEMBL312742 Ki 6.8 nM
Clc1cc2c(cc1Cl)N1CCNC[C@@H]1CN2 CHEMBL291794 Ki 7.0 nM
CN(C)CCc1cn(C)c2cccc(O)c12 CHEMBL197664 Ki 7.0 nM
O=C1c2c(cccc2C(F)(F)F)[C@@H]2CNCCN12 CHEMBL222514 Ki 7.0 nM
CN(CC1CC1)S(=O)(=O)c1ccc2c(c1)CCNCC2 CHEMBL493951 Ki 7.0 nM
O=S(=O)(c1ccc2c(c1)CCNCC2)c1ccccc1F CHEMBL449999 EC50 7.0 nM
Cc1cccc([C@H]2C[C@@H]2CN)c1C CHEMBL475642 EC50 7.0 nM
CC(O)c1ccccc1S(=O)(=O)c1ccc(/C=C/c2ccc(F)cc2)cc1 CHEMBL1084721 Ki 7.0 nM
CCCN(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1 CHEMBL1222363 IC50 7.0 nM
CN(C)[C@@H]1Cc2ccccc2[C@@H](C2CCCCC2)C1 CHEMBL3402656 Ki 7.0 nM
CCn1nc(-c2cccc3ccncc23)cc1-c1ccc(N)nn1 CHEMBL4073363 EC50 7.0 nM
COc1cc(CCNCc2ccccc2OC)c(OC)cc1I CHEMBL1908863 Ki 7.0 nM
CNCC1CC2c3ccccc3Cc3ccccc3N2O1 CHEMBL81485 pIC50 7.079 nM
Brc1ccc2c3c1CCN3CCNC2 CHEMBL4635854 Ki 7.1 nM
NCC1CC1c1cc(F)c(F)cc1OCCF CHEMBL3769828 pEC50 7.244 nM
CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1 CHEMBL128 IC50 7.3 nM
Cc1cc2cc(CN3CCCC3)cnc2cc1NC(=O)c1ccc(-c2ccc(F)cc2)cc1 CHEMBL2031730 IC50 7.4 nM
C[C@H](N)Cn1ncc2cc(Cl)c(Cl)cc21 CHEMBL256420 Ki 7.5 nM
Fc1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1 CHEMBL4212834 EC50 7.5 nM
CN(C)CC1CC2c3c(cccc3C(F)(F)F)Cc3ccccc3N2O1 CHEMBL84810 pIC50 7.586 nM
CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1 CHEMBL195706 Ki 7.6 nM
COc1cc(F)c(Cl)cc1C1CC1CN CHEMBL3770689 EC50 7.6 nM
COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(O)cc32)cc1OC CHEMBL5178632 EC50 7.6 nM
COc1ccccc1Cc1c(N)nc(SCCN2CCN(Cc3ccccc3C(F)(F)F)CC2)nc1N CHEMBL106794 Ki 7.7 nM
Cn1c2c(c3ccccc31)CCNCC2 CHEMBL6557 EC50 7.7 nM
COc1cc(CCNCc2cccc3ccsc23)c(OC)cc1Br CHEMBL3589580 pKi 7.762 nM
CN(C)CCc1c[nH]c2cccc(O)c12 CHEMBL65547 IC50 7.79 nM
COc1cccc(Nc2nc(N3CCN(C)CC3)nc3c2cnn3C)c1 CHEMBL574533 IC50 7.8 nM
COc1cccc(Nc2nc(N3CCN(C)CC3)nc3[nH]ncc23)c1 CHEMBL2393402 IC50 7.8 nM
Cc1ccc2c(c1Br)CCN2C(=O)Nc1cccnc1 CHEMBL42463 Ki 7.9 nM
O=C(Nc1cccnc1)N1CCc2cc(Cl)c(Cl)cc21 CHEMBL297043 Ki 7.9 nM
CC(N)Cn1ccc2cc(Cl)ccc21 CHEMBL328844 Ki 7.9 nM
Oc1cc2c3c(c1Cl)-c1ccccc1C[C@@H]3NCC2 CHEMBL5399789 EC50 7.9 nM
O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2ccc(C(F)(F)F)cc21 CHEMBL56405 Log Ki 7.943 nM
COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C#N)cc1 CHEMBL90175 Log Ki 7.943 nM
CC(N)Cn1ccc2c(F)cccc21 CHEMBL92565 Log Ki 7.943 nM
Cc1ccc2c(c1)-c1c(ccn1CC(C)N)C2 CHEMBL96312 Log Ki 7.943 nM
COc1ccc(N2CCN(c3ccc(C)c(C(F)(F)F)c3)C2=O)cc1OCCN1CCOCC1 CHEMBL198109 pKi 7.943 nM
COc1ccc(-n2ccn(-c3cc(F)cc(F)c3)c2=O)cc1OCCN1CCCCC1 CHEMBL198015 pKi 7.943 nM
COc1ccc(N2CC=C(c3ccc(Cl)c(F)c3)C2=O)cc1OCCN1CCC(C)CC1 CHEMBL211466 Log Ki 7.943 nM
COc1ccc(N2CC=C(c3ccc(Cl)cc3)C2=O)cc1OCCN1CCCCC1 CHEMBL208894 Log Ki 7.943 nM
COc1ccc(N2CC=C(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCC(F)(F)CC1 CHEMBL210124 Log Ki 7.943 nM
Clc1cccc(N2CCNCC2)c1 CHEMBL478 Log EC50 7.943 nM
COc1cc2c(cc1Cl)[C@@H](C)CNCC2 CHEMBL253806 Log EC50 7.943 nM
COc1cc2c(cc1Cl)C(C)CNCC2 CHEMBL181787 Log EC50 7.943 nM
C[C@@H]1CNCCc2cc(Cl)c(Cl)cc21 CHEMBL253805 Log EC50 7.943 nM
C[C@H]1CNCCc2ccc(C(F)(F)F)cc21 CHEMBL254009 Log EC50 7.943 nM
CN(C)C1CC[C@]2(Cc3ccccc3Cc3ccccc32)C1 CHEMBL1278116 pKi 7.943 nM
CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 CHEMBL3217984 pKi 7.943 nM
Cc1cccc([C@@]2(F)C[C@@H]2CN)c1 CHEMBL4570151 pEC50 7.943 nM
Clc1cc2c(cc1Cl)N1CCNC[C@H]1CN2 CHEMBL61695 Ki 8.0 nM
COc1cc2c(cc1Br)CCNCC2 CHEMBL180166 EC50 8.0 nM
O=C(NCc1ccc(-c2cc(Cl)cc(Cl)c2)cc1)[C@@H]1CCCN1 CHEMBL1092167 Ki 8.0 nM
CC(C)C(=O)NCc1ccc2c(c1)[C@H](N1CCN(C)CC1)Cc1ccccc1S2 CHEMBL1259189 Ki 8.0 nM
CC(Oc1cncc(N2CCNCC2)n1)c1cccc(F)c1 CHEMBL2260566 Ki 8.0 nM
Cc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2 CHEMBL2397896 EC50 8.0 nM
CCc1cccc2c1C(=O)N1CCNC[C@H]1C2 CHEMBL2397890 Ki 8.0 nM
c1cc2c3c(c1)[C@H]1CCC[C@H]1N3CCNC2 CHEMBL1628670 EC50 8.0 nM
CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(Cl)c2)C1 CHEMBL3402675 Ki 8.0 nM
CN(C)CCN(Cc1ccccc1)S(=O)(=O)c1ccc(I)cc1 CHEMBL3753894 Ki 8.0 nM
CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 CHEMBL4277390 Ki 8.0 nM
Cc1cc2c3c(c1Cl)C(C)CN3CCNC2 CHEMBL4644872 Ki 8.0 nM
CNCCC=C1c2ccccc2CCc2ccccc21 CHEMBL445 Ki 8.169 nM
Cc1ncccc1Oc1ccc(NC(=O)c2c[nH]c3c(C)cccc23)cn1 CHEMBL451486 IC50 8.2 nM
COc1ccc2[nH]cc(CC(C)N)c2c1 CHEMBL31115 Ki 8.3 nM
CCN(C)CCc1c(-c2cccc(F)c2)[nH]c2ccccc12 CHEMBL328595 Ki 8.4 nM
O=C1Cc2cc(OC3CN(c4c5c(nc6ccnn46)CCNCC5)C3)ccc2N1 CHEMBL1643859 EC50 8.4 nM
CC(C)Oc1ccccc1Cc1c(N)nc(SCCN2CCN(Cc3cccc(C(F)(F)F)c3)CC2)nc1N CHEMBL321785 Ki 8.6 nM
Nc1nc(SCCN2CCN(Cc3ccccc3Cl)CC2)nc(N)c1Cc1ccccc1Cl CHEMBL106176 Ki 8.7 nM
C=CCOc1cc(F)c(F)cc1C1CC1CN CHEMBL3769968 EC50 8.7 nM
Clc1ccc2c(c1Cl)CCNCC2 CHEMBL262862 Ki 8.8 nM
CCN(CC)CCOc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1ccnn1C CHEMBL568841 Ki 8.8 nM
CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1 CHEMBL193435 Ki 8.9 nM
COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2 CHEMBL4761526 EC50 8.9 nM
COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1 CHEMBL5170784 EC50 8.9 nM
C=CCOc1ccc(F)cc1[C@H]1C[C@@H]1CNCc1ccccc1OC CHEMBL4063893 pEC50 8.913 nM
Cc1c(CCN)c2cccc3c2n1CCC3 CHEMBL170854 EC50 9.0 nM
O=C1Nc2cc(C(F)(F)F)c(Cl)cc2N2CCNCC12 CHEMBL304013 Ki 9.0 nM
CC(N)Cc1c[nH]c2ccc3ccccc3c12 CHEMBL40815 Ki 9.0 nM
O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCCCC1 CHEMBL455039 Ki 9.0 nM
O=S(=O)(c1cccc(F)c1)c1ccc2c(c1)CCNCC2 CHEMBL492910 EC50 9.0 nM
NC[C@H]1C[C@@H]1c1ccc(F)c(F)c1 CHEMBL492306 EC50 9.0 nM
Cn1nccc1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCCN1CCCC1 CHEMBL569510 Ki 9.0 nM
Cn1ncc(Br)c1-c1cc(NC(=O)Nc2ccc(F)cc2)ccc1OCCN1CCCC1 CHEMBL583624 Ki 9.0 nM
CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 CHEMBL4281915 Ki 9.0 nM
CCOc1ccccc1Cc1c(N)nc(SCCN2CCN(Cc3cccc(C(F)(F)F)c3)CC2)nc1N CHEMBL440513 Ki 9.1 nM
COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1 CHEMBL2393246 EC50 9.2 nM
C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN CHEMBL4759878 EC50 9.2 nM
CC(CN)c1c[nH]c2ccccc12 CHEMBL148463 Ki 9.3 nM
NC[C@@H]1C[C@@H]1c1cc(O)ccc1OCC1CC1 CHEMBL5413973 EC50 9.3 nM
C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 CHEMBL2391541 pEC50 9.333 nM
COc1cc(CCNCc2cccc3nc[nH]c23)c(OC)cc1Br CHEMBL3589583 pKi 9.333 nM
Clc1cccc(COc2cncc(N3CCNCC3)n2)c1 CHEMBL4743049 Ki 9.447 nM
Cc1ccc2c(c1C)N1[C@H](CNC[C@H]1C)C2 CHEMBL364534 Ki 9.5 nM
COc1ccc(F)c(F)c1C1CC1CN CHEMBL3770963 EC50 9.5 nM
NCCn1ncc2ccc(O)cc21 CHEMBL199385 Ki 9.6 nM
CNCC1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1 CHEMBL329685 Ki 9.7 nM
COc1cc(Cl)c(Cl)cc1C1CC1CN CHEMBL3769543 EC50 9.7 nM