O=C1c2cccc3c2[C@H](CCC3)CN1[C@@H]1CN2CCC1CC2 CHEMBL1189679 pKi 0.03162 nM
CN1CCN(c2nc3ccccc3nc2Cl)CC1 CHEMBL261010 Ki 0.04 nM
CN1CCN(c2nc(N)c3ccccc3n2)CC1 CHEMBL475331 pKi 0.05129 nM
Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21 CHEMBL1643895 Ki 0.06 nM
Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O CHEMBL46 IC50 0.09 nM
CC(C)n1cnc2c(C(=O)N[C@@H]3CN4CCC3CC4)cc(Cl)cc21 CHEMBL145033 Log Ki 0.138 nM
CC(C)n1cnc2c(C(=O)N[C@H]3CN4CCC3CC4)cc(Cl)cc21 CHEMBL145725 Log Ki 0.1445 nM
CN1[C@H]2CCC[C@H]1CC(NC(=O)c1nn(C)c3cccc(O)c13)C2 CHEMBL596951 Ki 0.17 nM
CN1C2CCCC1CC(OC(=O)c1cn(CCF)c3ccccc13)C2 CHEMBL3916920 IC50 0.18 nM
COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 CHEMBL28992 Log Ki 0.182 nM
CN1C2CCCC1CC(NC(=O)c1nn(C)c3ccccc13)C2 CHEMBL289469 Kd 0.19 nM
Cc1cn2c3c(cc(Cl)cc13)C(=O)N([C@@H]1CN3CCC1CC3)CC2 CHEMBL3261480 Ki 0.2 nM
CN1C2CCCC1CC(OC(=O)c1c(Cl)n(CCF)c3ccccc13)C2 CHEMBL3933362 IC50 0.2 nM
CN1C2COCC1CC(NC(=O)c1cn(CCF)c3ccccc13)C2 CHEMBL3891400 IC50 0.22 nM
Cc1c(C(=O)OC2CC3CCCC(C2)N3C)c2ccccc2n1CCF CHEMBL3948240 IC50 0.22 nM
CN1[C@H]2CCC[C@H]1CC(NC(=O)c1nn(C)c3c(OCc4ccccc4)cccc13)C2 CHEMBL605772 Ki 0.23 nM
CN1C2COCC1CC(NC(=O)c1cn(CC(F)F)c3ccccc13)C2 CHEMBL3979389 IC50 0.23 nM
CN1C2COCC1CC(OC(=O)c1cn(CC(F)F)c3ccc(F)cc13)C2 CHEMBL3900767 IC50 0.24 nM
CN1C2COCC1CC(NC(=O)c1cn(-c3cccnn3)c3ccccc13)C2 CHEMBL3923591 IC50 0.28 nM
CN1C2COCC1CC(OC(=O)c1cn(S(C)(=O)=O)c3ccc(F)cc13)C2 CHEMBL3968090 IC50 0.29 nM
CN1C2COCC1CC(NC(=O)c1cn(CC#N)c3ccccc13)C2 CHEMBL3895177 IC50 0.2985 nM
C[C@@H]1CCCN1CCCOc1ccc(-c2cnn(-c3ccccn3)c(=O)c2)cc1 CHEMBL1945843 Kb 0.3 nM
CN1C2COCC1CC(NC(=O)c1cn(-c3cncn3C)c3ccccc13)C2 CHEMBL3979838 IC50 0.328 nM
c1ccc2c(NCCc3ccc(OCCCN4CCCCC4)cc3)c3c(nc2c1)CCCC3 CHEMBL15056 Ki 0.33 nM
CN1C2COCC1CC(OC(=O)c1cn(S(C)(=O)=O)c3ccccc13)C2 CHEMBL3956338 IC50 0.33 nM
c1ccc(Cn2c(N3CCNCC3)nc3ccccc32)cc1 CHEMBL56900 Ki 0.36 nM
COc1cc(N)c(Cl)cc1C(=O)NC1CN2CCC1CC2 CHEMBL18041 Ki 0.39 nM
CN1C2COCC1CC(NC(=O)c1cn(-c3cncnc3)c3ccccc13)C2 CHEMBL3960051 IC50 0.39 nM
CN1C2COCC1CC(NC(=O)c1cn(-c3cncs3)c3ncccc13)C2 CHEMBL3948391 IC50 0.4 nM
CN1C2COCC1CC(NC(=O)c1nn(CC(F)F)c3ccccc13)C2 CHEMBL3941887 IC50 0.4 nM
CN1C2COCC1CC(NC(=O)c1cn(-c3cncs3)c3ccccc13)C2 CHEMBL3929017 IC50 0.4 nM
O=C(NC1CC2COCC(C1)N2)c1cn(CC(F)F)c2ccccc12 CHEMBL3982898 IC50 0.4 nM
CN1C2COCC1CC(NC(=O)c1cn(-c3cscn3)c3ncccc13)C2 CHEMBL3924093 IC50 0.4 nM
O=C(OC1CC2COCC(C1)N2)c1cn(-c2cnsc2)c2ccccc12 CHEMBL3938528 IC50 0.4155 nM
COc1ccccc1-c1csc(Cc2[nH]cnc2C)n1 CHEMBL93919 Ki 0.42 nM
COc1ccc(Cn2c(N3CCNCC3)nc3ccccc32)cc1 CHEMBL66692 Ki 0.42 nM
CN1C2CCC1CC(NC(=O)c1cn(S(C)(=O)=O)c3ccccc13)C2 CHEMBL3955543 IC50 0.42 nM
CN1C2CCCC1CC(OC(=O)c1cn(CC(F)F)c3ccc(F)cc13)C2 CHEMBL3934819 IC50 0.44 nM
CN1C2CCCC1CC(NC(=O)c1nn(CCF)c3ccccc13)C2 CHEMBL3895498 IC50 0.45 nM
CN1CCN(c2ccc3ccccc3n2)CC1 CHEMBL288591 pKi 0.4571 nM
CN1C2COCC1CC(OC(=O)c1cn(-c3cncnc3)c3ccccc13)C2 CHEMBL3891620 IC50 0.46 nM
CN1[C@@H]2COC[C@H]1C[C@@H](OC(=O)c1cn(-c3cn[nH]c3)c3ccccc13)C2 CHEMBL3944903 IC50 0.462 nM
CN1C2CCCC1CC(NC(=O)c1nn(CC(F)F)c3ccccc13)C2 CHEMBL3979379 IC50 0.49 nM
CN1C2COCC1CC(NC(=O)c1cn(CC(F)F)c3ccc(F)cc13)C2 CHEMBL3973304 IC50 0.49 nM
Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O CHEMBL1110 Ki 0.5 nM
O=C1c2cc(Cl)cc3cnn(c23)CCN1[C@@H]1CN2CCC1CC2 CHEMBL3261483 Ki 0.5 nM
CN1C2COCC1CC(NC(=O)c1cn(S(C)(=O)=O)c3ccc(F)cc13)C2 CHEMBL3984877 IC50 0.5 nM
CN1[C@@H]2COC[C@H]1C[C@@H](NC(=O)c1cn(-c3cccnc3)c3ccccc13)C2 CHEMBL3890437 IC50 0.51 nM
CN1C2CCC1CC(OC(=O)c1cn(CCF)c3ccccc13)C2 CHEMBL3920436 IC50 0.53 nM
Cc1c(C(=O)OC2CC3CCC(C2)N3C)c2ccccc2n1CCF CHEMBL3956047 IC50 0.53 nM
CN1C2COCC1CC(NC(=O)c1cn(CC(F)(F)F)c3ccccc13)C2 CHEMBL3904293 IC50 0.53 nM
CN1C2CCC1CC(OC(=O)c1cn(S(C)(=O)=O)c3ccccc13)C2 CHEMBL3947651 IC50 0.54 nM
CN1C2COCC1CC(NC(=O)c1cn(CC(F)(F)F)c3ccc(F)cc13)C2 CHEMBL3927586 IC50 0.54 nM
CN1C2COCC1CC(NC(=O)c1cn(-c3cnccn3)c3ccccc13)C2 CHEMBL3921737 IC50 0.55 nM
CC(C)S(=O)(=O)n1cc(C(=O)NC2CC3COCC(C2)N3C)c2ccccc21 CHEMBL3923484 IC50 0.57 nM
CN1C2CCCC1CC(NC(=O)c1nn(S(C)(=O)=O)c3ccccc13)C2 CHEMBL3981749 IC50 0.59 nM
CN1C2COCC1CC(OC(=O)c1cn(-c3ccc(O)nn3)c3ccccc13)C2 CHEMBL3962464 IC50 0.5975 nM
C[C@H]1COC[C@H](C)N1c1nc2c(C(=O)N[C@@H]3C[C@H]4CCC[C@@H](C3)N4C)cccc2o1 CHEMBL3084769 Ki 0.6 nM
CN1C2COCC1CC(OC(=O)c1cn(CCF)c3ncccc13)C2 CHEMBL3935292 IC50 0.6 nM
CN1[C@@H]2COC[C@H]1C[C@@H](NC(=O)c1cn(-c3cccnc3)c3ncccc13)C2 CHEMBL3978812 IC50 0.6 nM
CN1C2COCC1CC(NC(=O)c1cn(-c3cnsc3)c3ccccc13)C2 CHEMBL3971611 IC50 0.61 nM
O=C(O[C@H]1C[C@H]2COC[C@@H](C1)N2)c1cn(-c2cccnc2)c2ccccc12 CHEMBL3905913 IC50 0.62 nM
CN1[C@@H]2COC[C@H]1C[C@@H](NC(=O)c1cn(-c3ccccn3)c3ncccc13)C2 CHEMBL3911935 IC50 0.65 nM
Cn1nccc1-n1cc(C(=O)O[C@H]2C[C@H]3COC[C@@H](C2)N3)c2ccccc21 CHEMBL3950793 IC50 0.65 nM
CN1C2CCCC1CC(OC(=O)c1cn(CC(F)(F)F)c3ccc(F)cc13)C2 CHEMBL3911488 IC50 0.66 nM
CN1[C@@H]2COC[C@H]1C[C@@H](NC(=O)c1cn(-c3cnn(C)c3)c3ccccc13)C2 CHEMBL3901835 IC50 0.662 nM
CN1[C@H]2CCC[C@H]1CC(NC(=O)c1nn(C)c3c(O)cccc13)C2 CHEMBL599011 Ki 0.67 nM
Cn1cc(-n2cc(C(=O)O[C@H]3C[C@H]4COC[C@@H](C3)N4)c3ccccc32)cn1 CHEMBL3973885 IC50 0.68 nM
CN1C2COCC1CC(OC(=O)c1cn(-c3ccc(F)nn3)c3ccccc13)C2 CHEMBL3984660 IC50 0.681 nM
CN1[C@@H]2COC[C@H]1C[C@@H](NC(=O)c1cn(-c3ccncc3)c3ccccc13)C2 CHEMBL3976639 IC50 0.69 nM
Cn1nc2c3c(cccc31)C(=O)N([C@@H]1CN3CCC1CC3)C2 CHEMBL1643884 Ki 0.7 nM
Cn1cc2c3c(cccc31)C(=O)N([C@@H]1CN3CCC1CC3)C2 CHEMBL1643894 Ki 0.7 nM
CN1C2COCC1CC(NC(=O)c1cn(-c3nccs3)c3ncccc13)C2 CHEMBL3960503 IC50 0.702 nM
CN1[C@@H]2COC[C@H]1C[C@@H](NC(=O)c1cn(-c3cccnc3)c3ncc(F)cc13)C2 CHEMBL3987099 IC50 0.72 nM
CN1C2CCCC1CC(OC(=O)c1cn(S(C)(=O)=O)c3ccc(F)cc13)C2 CHEMBL3955200 IC50 0.74 nM
O=C(N[C@H]1C[C@H]2COC[C@@H](C1)N2)c1cn(-c2cn[nH]c2)c2ccccc12 CHEMBL3920493 IC50 0.745 nM
CN1C2COCC1CC(OC(=O)c1cn(CCF)c3ccc(C#N)cc13)C2 CHEMBL3966488 IC50 0.746 nM
CN1C2CCC1CC(NC(=O)c1nn(S(C)(=O)=O)c3ccccc13)C2 CHEMBL3947167 IC50 0.75 nM
CN1C2CCC1CC(NC(=O)c1nn(CC(F)F)c3ccccc13)C2 CHEMBL3939459 IC50 0.75 nM
CN1C2COCC1CC(NC(=O)c1cn(-c3ccnnc3)c3ccccc13)C2 CHEMBL3909570 IC50 0.75 nM
CN1[C@@H]2COC[C@H]1C[C@@H](NC(=O)c1cn(-c3ccn(C)n3)c3ccccc13)C2 CHEMBL3950406 IC50 0.75 nM
CN1C2CCC1CC(OC(=O)c1cn(CC(F)F)c3ccccc13)C2 CHEMBL3893818 IC50 0.78 nM
Cc1cc2c3c(cnn3CCN([C@@H]3CN4CCC3CC4)C2=O)c1 CHEMBL3261484 Ki 0.8 nM
Cc1cc2c3c(cnn3CCN(C3CN4CCC3CC4)C2=O)c1 CHEMBL3673243 Ki 0.8 nM
CN1[C@@H]2COC[C@H]1C[C@@H](NC(=O)c1cn(-c3ccccn3)c3ccccc13)C2 CHEMBL3914905 IC50 0.81 nM
CN1C2CCC1CC(OC(=O)c1cn([C@H]3CCOC3)c3ccccc13)C2 CHEMBL3905810 IC50 0.83 nM
CN1C2COCC1CC(OC(=O)c1cn(CC(F)F)c3ncccc13)C2 CHEMBL3973732 IC50 0.84 nM
CN1C2COCC1CC(NC(=O)c1cn(-c3nccs3)c3ccccc13)C2 CHEMBL3951304 IC50 0.86 nM
CN1C2COCC1CC(NC(=O)c1nn(CC(F)(F)F)c3ccccc13)C2 CHEMBL3958157 IC50 0.86 nM
CN1C2COCC1CC(NC(=O)c1cn(-c3ccsn3)c3ccccc13)C2 CHEMBL3909661 IC50 0.87 nM
CN1[C@@H]2COC[C@H]1C[C@@H](NC(=O)c1cn(-c3ccccn3)c3ncc(F)cc13)C2 CHEMBL3917359 IC50 0.8825 nM
CN1C2CCC1CC(OC(=O)c1cn(CC(F)F)c3ccc(F)cc13)C2 CHEMBL3919866 IC50 0.89 nM
CN1C2CCC1CC(OC(=O)c1cn(CC(F)(F)F)c3ccccc13)C2 CHEMBL3925926 IC50 0.89 nM
Cn1cc2c3c(cccc31)C(=O)N([C@H]1CN3CCC1CC3)C2 CHEMBL1643893 Ki 0.9 nM
COc1ccc(C2=[N+]3C(=Cc4c(C)c(CCC(=O)NCCCCCC(=O)NCCCn5nc(C(=O)N[C@@H]6C[C@H]7CCC[C@@H](C6)N7C)c6ccccc65)c(C)n4[B-]3(F)F)C=C2)cc1 CHEMBL3084430 Ki 0.9 nM
CN1C2CCC1CC(OC(=O)c1c(Cl)n(CCF)c3ccccc13)C2 CHEMBL3920932 IC50 0.9 nM
O=C(OC1CC2COCC(C1)N2)c1cn(-c2cccnn2)c2ccccc12 CHEMBL3959461 IC50 0.914 nM
CN1C2CCC1CC(OC(=O)c1c(Cl)n(S(C)(=O)=O)c3ccccc13)C2 CHEMBL3925843 IC50 0.93 nM
O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21 CHEMBL4867565 Ki 0.93 nM
CN1C2CCC1CC(OC(=O)c1cn(C3CCOC3)c3ccccc13)C2 CHEMBL3986091 IC50 0.94 nM
CN1C2COCC1CC(OC(=O)c1cn(CC#N)c3c(F)nccc13)C2 CHEMBL3917810 IC50 0.9457 nM
CN1C2CCC1CC(OC(=O)c1cn(C3CCOC3)c3ccc(F)cc13)C2 CHEMBL3904155 IC50 0.95 nM
CN1C2COCC1CC(NC(=O)c1cn(CC(F)F)c3ncc(F)cc13)C2 CHEMBL3986850 IC50 0.95 nM
O=C(O[C@H]1C[C@H]2COC[C@@H](C1)N2)c1cn(-c2ccncc2)c2ccccc12 CHEMBL3963201 IC50 0.95 nM
CC(C)n1cnc2c(C(=O)NC3CC4CCC(C3)N4C)cc(Cl)cc21 CHEMBL142852 Log Ki 1.0 nM
Cc1[nH]cnc1Cc1nc(-c2cccc3cccnc23)cs1 CHEMBL421747 Ki 1.0 nM
CCn1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 CHEMBL62023 Ki 1.0 nM
CC[C@H]1COC[C@H](C)N1c1nc2c(C(=O)N[C@@H]3C[C@H]4CCC[C@@H](C3)N4C)cccc2o1 CHEMBL3084770 Ki 1.0 nM
O=C(N[C@H]1CN2CCC1CC2)c1cc(Cl)cc2c1OCC2 CHEMBL419496 Ki 1.0 nM
CN1Nc2cn([C@@H]3CN4CCC3CC4)c(=O)c3cccc1c23 CHEMBL3679393 Ki 1.0 nM
CCN1Nc2cn([C@@H]3CN4CCC3CC4)c(=O)c3cccc1c23 CHEMBL3679396 Ki 1.0 nM
O=c1c2cc(Br)cc3c2c(cn1[C@H]1CN2CCC1CC2)NN3 CHEMBL3679406 Ki 1.0 nM
CCn1nc2c3c(cccc31)C(=O)N([C@@H]1CN3CCC1CC3)CC2 CHEMBL3679409 Ki 1.0 nM
Cn1cc2c3c(cccc31)C(=O)N([C@@H]1CN3CCC1CC3)CC2 CHEMBL3679413 Ki 1.0 nM
O=C1c2cccc3c2c(cn3Cc2ccccc2)CCN1[C@@H]1CN2CCC1CC2 CHEMBL3679414 Ki 1.0 nM
CN1C2CCCC1CC(OC(=O)c1cn(CC(F)F)c3ncccc13)C2 CHEMBL3962329 IC50 1.0 nM
CN1C2COCC1CC(NC(=O)c1cn(-c3ncccn3)c3ccccc13)C2 CHEMBL3896008 IC50 1.01 nM
CN1[C@@H]2COC[C@H]1C[C@@H](NC(=O)c1cn(-c3ccnn3C)c3ccccc13)C2 CHEMBL3979768 IC50 1.01 nM
CN1C2CCC1CC(OC(=O)c1c(Cl)n(CC(F)F)c3ccccc13)C2 CHEMBL3916337 IC50 1.02 nM
CN1C2COCC1CC(NC(=O)c1cn(-c3ncco3)c3ccccc13)C2 CHEMBL3911435 IC50 1.027 nM
CN1C2COCC1CC(NC(=O)c1cn(C(F)(F)C(F)F)c3ncccc13)C2 CHEMBL3919487 IC50 1.03 nM
Cc1c(C(=O)OC2CC3CCC(C2)N3C)c2ccccc2n1S(C)(=O)=O CHEMBL3960233 IC50 1.03 nM
CN1C2CCC1CC(OC(=O)c1cn([C@@H]3CCOC3)c3ccccc13)C2 CHEMBL4111059 IC50 1.04 nM
CN1C2CCC1CC(OC(=O)c1c3n(c4ccccc14)CCCO3)C2 CHEMBL3960386 IC50 1.04 nM
CN1C2COCC1CC(NC(=O)c1cn(C(F)(F)C(F)F)c3ncc(F)cc13)C2 CHEMBL3929838 IC50 1.05 nM
CN1C2COCC1CC(NC(=O)c1cn(CC(C)(F)F)c3ncccc13)C2 CHEMBL3932951 IC50 1.05 nM
CN1C2COCC1CC(NC(=O)c1cn(CC(F)(F)F)c3ncc(F)cc13)C2 CHEMBL3892459 IC50 1.05 nM
CN1C2COCC1CC(NC(=O)c1cn(C(C)(C)C(F)(F)F)c3ncccc13)C2 CHEMBL3906341 IC50 1.06 nM
CN1C2COCC1CC(NC(=O)c1nn(CC(F)F)c3ncccc13)C2 CHEMBL3930983 IC50 1.07 nM
CN1C2CCC1CC(OC(=O)c1c3n(c4ccccc14)CCO3)C2 CHEMBL3928641 IC50 1.08 nM
CN1[C@@H]2CCC[C@H]1C[C@H](NC(=O)c1nn(CCCCNC(=S)Nc3ccc(-c4c5ccc(=O)cc-5oc5cc(O)ccc45)c(C(=O)O)c3)c3ccccc13)C2 CHEMBL3084434 Ki 1.1 nM
CN1C2COCC1CC(OC(=O)c1cn(-c3cnccn3)c3ccccc13)C2 CHEMBL3923885 IC50 1.1 nM
Cc1ccncc1-n1cc(C(=O)N[C@H]2C[C@H]3COC[C@@H](C2)N3C)c2ccccc21 CHEMBL3974896 IC50 1.1 nM
N#Cc1ccccc1-n1cc(C(=O)OC2CC3COCC(C2)N3)c2ccccc21 CHEMBL3896919 IC50 1.105 nM
O=C(OC1CC2COCC(C1)N2)c1cn(-c2cnccn2)c2ccccc12 CHEMBL3947319 IC50 1.119 nM
CNc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12 CHEMBL489062 pKi 1.122 nM
CN1C2COCC1CC(NC(=O)c1cn([C@@H](F)C(F)(F)F)c3ncccc13)C2 CHEMBL4114119 IC50 1.13 nM
CN1C2COCC1CC(NC(=O)c1cn([C@H](F)C(F)(F)F)c3ncccc13)C2 CHEMBL3943285 IC50 1.13 nM
Cn1ccc(-n2cc(C(=O)OC3CC4COCC(C3)N4)c3ccccc32)cc1=O CHEMBL3985721 IC50 1.165 nM
CN1C2COCC1CC(NC(=O)c1cn(-c3cncs3)c3ncc(F)cc13)C2 CHEMBL3915089 IC50 1.179 nM
N#CCn1cc(C(=O)OC2CC3COCC(C2)N3)c2ccccc21 CHEMBL3897074 IC50 1.18 nM
COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CN(C2)CC31 CHEMBL558226 Ki 1.2 nM
CN(C)c1cccc2c(S(=O)(=O)NCCCn3nc(C(=O)N[C@H]4C[C@H]5CCC[C@@H](C4)N5C)c4ccccc43)cccc12 CHEMBL3084439 Ki 1.2 nM
CN1[C@@H]2COC[C@H]1C[C@@H](OC(=O)c1cn(-c3cnn(C)c3)c3ccccc13)C2 CHEMBL3959374 IC50 1.2 nM
CN1C2CCC1CC(NC(=O)c1cn(CC(F)F)c3ncccc13)C2 CHEMBL3966678 IC50 1.22 nM
CN1C2COCC1CC(OC(=O)c1cn(-c3cnc(F)cn3)c3ccccc13)C2 CHEMBL3934011 IC50 1.25 nM
O=C(OC1CC2COCC(C1)N2)c1cn(-c2ccns2)c2ccccc12 CHEMBL3968902 IC50 1.26 nM
CN1C2COCC1CC(OC(=O)c1cn(-c3cncs3)c3ccccc13)C2 CHEMBL3951841 IC50 1.27 nM
O=C(OC1CC2COCC(C1)N2)c1cn(CC(F)F)c2ccc(F)cc12 CHEMBL3905347 IC50 1.29 nM
CN1[C@@H]2COC[C@H]1C[C@@H](NC(=O)c1nn(-c3ccccn3)c3ccccc13)C2 CHEMBL3926346 IC50 1.34 nM
CN1CCN(c2ncc3ccccc3n2)CC1 CHEMBL443764 pKi 1.349 nM
CN1C2COCC1CC(NC(=O)c1cn(CC(F)(F)F)c3ncccc13)C2 CHEMBL3984294 IC50 1.35 nM
CN1C2COCC1CC(NC(=O)c1cn(-c3ccns3)c3ccccc13)C2 CHEMBL3894103 IC50 1.36 nM
CN1[C@@H]2COC[C@H]1C[C@@H](NC(=O)c1cn(-c3ccc[n+]([O-])c3)c3ccccc13)C2 CHEMBL3936092 IC50 1.36 nM
CN1C2COCC1CC(OC(=O)c1cn(CC(F)(F)F)c3ccc(F)cc13)C2 CHEMBL3942335 IC50 1.38 nM
CC(C)S(=O)(=O)n1cc(C(=O)NC2CC3COCC(C2)N3C)c2cc(F)ccc21 CHEMBL3893418 IC50 1.39 nM
CN1[C@@H]2COC[C@H]1C[C@@H](NC(=O)c1cn(-c3cnn(C(F)F)c3)c3ccccc13)C2 CHEMBL3935377 IC50 1.39 nM
CN1C2CCCC1CC(OC(=O)c1nn(S(C)(=O)=O)c3ccccc13)C2 CHEMBL3918054 IC50 1.4 nM
c1ccc(CN2CCN(c3nc4ccsc4n4cccc34)CC2)cc1 CHEMBL54720 pIC50 1.413 nM
c1ccc2cc(Cn3c(N4CCNCC4)nc4ccccc43)ccc2c1 CHEMBL63863 Ki 1.43 nM
CN1C2COCC1CC(NC(=O)c1cn(CC(F)F)c3ncccc13)C2 CHEMBL3912693 IC50 1.43 nM
CN1C2COCC1CC(NC(=O)c1cn(C(F)C(F)(F)F)c3ncccc13)C2 CHEMBL3946404 IC50 1.44 nM
O=C(N[C@H]1C[C@H]2COC[C@@H](C1)N2)c1cn(-c2cccnc2)c2ccccc12 CHEMBL3944338 IC50 1.44 nM
CN1CCN(c2cc(N)c3ccccc3n2)CC1 CHEMBL2169970 pKi 1.445 nM
CN1C2CCC1CC(OC(=O)c1cn([C@H]3CCOC3)c3ccc(F)cc13)C2 CHEMBL3929209 IC50 1.45 nM
CCS(=O)(=O)n1cc(C(=O)OC2CC3COCC(C2)N3)c2ccccc21 CHEMBL3936101 IC50 1.5 nM
CN(C(=O)c1cn(-c2cnsc2)c2ccccc12)C1CC2COCC(C1)N2C CHEMBL3928579 IC50 1.5 nM
Cc1ncccc1-n1cc(C(=O)N[C@H]2C[C@H]3COC[C@@H](C2)N3C)c2ccccc21 CHEMBL3942077 IC50 1.5 nM
CN1C2COCC1CC(NC(=O)c1nn(-c3cncs3)c3ccccc13)C2 CHEMBL3957067 IC50 1.533 nM
CN1CCC(=Cc2nc3cc(Cl)ccc3[nH]2)CC1 CHEMBL1824048 pKi 1.585 nM
CCn1nc2c3c(cccc31)C(=O)N([C@@H]1CN3CCC1CC3)C2 CHEMBL1643887 Ki 1.6 nM
CN1[C@@H]2CCC[C@H]1C[C@H](NC(=O)c1nn(CCCNC(=S)Nc3ccc(-c4c5ccc(=O)cc-5oc5cc(O)ccc45)c(C(=O)O)c3)c3ccccc13)C2 CHEMBL3084432 Ki 1.6 nM
CC1=CC(C)=[N+]2C1=C(CCCOC(=O)CCCn1nc(C(=O)N[C@@H]3C[C@H]4CCC[C@@H](C3)N4C)c3ccccc31)c1c(C)cc(C)n1[B-]2(F)F CHEMBL3084440 Ki 1.6 nM
Cc1n[nH]c(=O)cc1-c1ccc(OCCCN2CCC[C@H]2C)cc1 CHEMBL1958323 Ki 1.6 nM
CN1C2COCC1CC(OC(=O)c1cn(-c3ccsn3)c3ccccc13)C2 CHEMBL3942973 IC50 1.62 nM
CN1CCN(c2cc3ccccc3cn2)CC1 CHEMBL2169966 pKi 1.622 nM
CN1C2CCC1CC(OC(=O)c1c3n(c4ccccc14)CCCCO3)C2 CHEMBL3960290 IC50 1.64 nM
Cc1ccc(Cn2c(N3CCNCC3)nc3ccccc32)cc1 CHEMBL66918 Ki 1.69 nM
Cn1nc2c3c(cccc31)C(=O)N([C@H]1CN3CCC1CC3)C2 CHEMBL1643883 Ki 1.7 nM
Cc1nn(-c2ccccn2)c(=O)cc1-c1ccc(OCCCN2CCC[C@H]2C)cc1 CHEMBL1958333 Ki 1.7 nM
CN1C2CCC1CC(OC(=O)c1cn([C@@H]3CCOC3)c3ccc(F)cc13)C2 CHEMBL4112254 IC50 1.71 nM
CN1C2COCC1CC(OC(=O)c1cn(-c3ncccn3)c3ccccc13)C2 CHEMBL3919672 IC50 1.75 nM
Cc1[nH]cnc1Cc1nc(-c2ccccc2)cs1 CHEMBL38465 Ki 1.8 nM
Cc1cccc(-n2ncc(-c3ccc(OCCCN4CCC[C@H]4C)cc3)cc2=O)n1 CHEMBL1958331 Ki 1.8 nM
CC(C)S(=O)(=O)n1cc(C(=O)OC2CC3COCC(C2)N3)c2ccccc21 CHEMBL3978355 IC50 1.8 nM
CN1C2COCC1CC(NC(=O)c1cn(-c3cscn3)c3ncc(F)cc13)C2 CHEMBL3943065 IC50 1.81 nM
CN1C2COCC1CC(NC(=O)c1cn(-c3nccs3)c3ncc(F)cc13)C2 CHEMBL3971761 IC50 1.81 nM
O=C(NC1CC2COCC(C1)N2)c1cn(CC(F)(F)F)c2ncccc12 CHEMBL3902773 IC50 1.82 nM
CN1C2COCC1CC(OC(=O)c1cn(CC(F)(F)F)c3ncccc13)C2 CHEMBL3944258 IC50 1.82 nM
CN1C2CCC1CC(OC(=O)c1c(Cl)n(CC(F)(F)F)c3ccccc13)C2 CHEMBL3923015 IC50 1.87 nM
CN1[C@@H]2CCC[C@H]1C[C@@H](NC(=O)c1nn(CCCN)c3ccccc13)C2 CHEMBL2309589 Ki 1.89 nM
CCN(CC)c1ccc2cc(C(=O)NCCOc3cccc4c(C(=O)N[C@@H]5C[C@H]6CCC[C@@H](C5)N6C)nn(C)c34)c(=O)oc2c1 CHEMBL3084441 Ki 1.9 nM
C[C@@H]1CCCN1CCCOc1ccc(-c2cnn(C)c(=O)c2)cc1 CHEMBL1958133 Ki 1.9 nM
Cc1[nH]cnc1Cc1nc(-c2ccccc2F)cs1 CHEMBL329179 Ki 1.94 nM
O=C(OC1CC2COCC(C1)N2)c1cn(S(=O)(=O)C2CC2)c2ccccc12 CHEMBL3894667 IC50 1.99 nM
CN1[C@@H]2CCC[C@H]1C[C@H](NC(=O)c1cccc3oc(N4CCOC[C@@H]4C(C)(C)C)nc13)C2 CHEMBL3084768 Ki 2.0 nM
Cn1nc2c3c(cc(F)cc31)C(=O)N([C@H]1CN3CCC1CC3)C2 CHEMBL1643885 Ki 2.0 nM
CCn1nc2c3c(cccc31)C(=O)N([C@H]1CN3CCC1CC3)C2 CHEMBL1643886 Ki 2.0 nM
C[C@@H]1CCCN1CCCOc1ccc(-c2ccc(=O)[nH]n2)cc1 CHEMBL1829335 Ki 2.0 nM
Cc1nn(C)c(=O)cc1-c1ccc(OCCCN2CCC[C@H]2C)cc1 CHEMBL1958326 Ki 2.0 nM
O=C(N[C@@H]1CN2CCC1CC2)c1n[nH]c2ccccc12 CHEMBL2151439 Ki 2.0 nM
CC(C)N1Nc2cn([C@@H]3CN4CCC3CC4)c(=O)c3cccc1c23 CHEMBL3679398 Ki 2.0 nM
CC(C)CN1Nc2cn([C@@H]3CN4CCC3CC4)c(=O)c3cccc1c23 CHEMBL3679399 Ki 2.0 nM
CN1Nc2cn([C@H]3CN4CCC3CC4)c(=O)c3cccc1c23 CHEMBL3679390 Ki 2.0 nM
CN1Nc2cn([C@H]3CN4CCC3CC4)c(=O)c3cc(F)cc1c23 CHEMBL3679394 Ki 2.0 nM
CCN1Nc2cn([C@H]3CN4CCC3CC4)c(=O)c3cccc1c23 CHEMBL3679395 Ki 2.0 nM
Cn1nc2c3c(cccc31)C(=O)N([C@@H]1CN3CCC1CC3)CC2 CHEMBL3639782 Ki 2.0 nM
CC(C)n1nc2c3c(cccc31)C(=O)N([C@@H]1CN3CCC1CC3)CC2 CHEMBL3679410 Ki 2.0 nM
O=C1c2cccc3c2c(nn3Cc2ccccc2)CCN1[C@@H]1CN2CCC1CC2 CHEMBL3679411 Ki 2.0 nM
O=C1c2cc(O)cc3cnn(c23)CCN1C1CN2CCC1CC2 CHEMBL3673244 Ki 2.0 nM
O=C1c2cccc3[nH]nc(c23)CN1CC12CCN(CC1)CC2 CHEMBL3673251 Ki 2.0 nM
c1ccc(-c2cnc3c(c2)C[C@@]2(CN4CCC2CC4)O3)cc1 CHEMBL195345 Ki 2.0 nM
CN1[C@@H]2COC[C@H]1C[C@@H](OC(=O)c1cn(-c3cnn(CCF)c3)c3ccccc13)C2 CHEMBL3936610 IC50 2.013 nM
Cn1cc(-n2cc(C(=O)N[C@H]3C[C@H]4COC[C@@H](C3)N4)c3ccccc32)cn1 CHEMBL3973788 IC50 2.04 nM
CN1C2COCC1CC(NC(=O)c1cn(-c3ccccc3)c3ccccc13)C2 CHEMBL3902436 IC50 2.065 nM
CN1C2CCC1CC(OC(=O)c1cn(CC(F)(F)F)c3ccc(F)cc13)C2 CHEMBL3953315 IC50 2.13 nM
O=C(OC1CC2COCC(C1)N2)c1cn(-c2nccs2)c2ccccc12 CHEMBL3949515 IC50 2.16 nM
CC(C)n1nc2c3c(cccc31)C(=O)N([C@@H]1CN3CCC1CC3)C2 CHEMBL1643889 Ki 2.3 nM
CS(=O)(=O)n1cc(C(=O)OC2CC3COCC(C2)N3)c2ccccc21 CHEMBL3965964 IC50 2.3 nM
O=C(NC1CC2COCC(C1)N2)c1cn(CC(F)(F)F)c2ccc(F)cc12 CHEMBL3909121 IC50 2.33 nM
O=C(OC1CC2COCC(C1)N2)c1cn(CC(F)(F)F)c2ccc(F)cc12 CHEMBL3956912 IC50 2.36 nM
C[C@H]1CNC[C@H](C)N1c1nc2c(C(=O)N[C@@H]3C[C@H]4CCC[C@@H](C3)N4C)cccc2o1 CHEMBL3084776 Ki 2.4 nM
CC(C)Cn1nc2c3c(cccc31)C(=O)N([C@@H]1CN3CCC1CC3)C2 CHEMBL1641625 Ki 2.4 nM
CN1C2CCC1CC(OC(=O)c1cn(S(C)(=O)=O)c3ccc(F)cc13)C2 CHEMBL3894914 IC50 2.48 nM
Cc1cccnc1-n1ncc(-c2ccc(OCCCN3CCC[C@H]3C)cc2)cc1=O CHEMBL1958332 Ki 2.5 nM
CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)c1cc(Cl)cc(Cl)c1)C2 CHEMBL2107804 Ki 2.5 nM
Cn1ccc(-n2cc(C(=O)O[C@H]3C[C@H]4COC[C@@H](C3)N4)c3ccccc32)n1 CHEMBL3963431 IC50 2.5 nM
CN1CCN(c2nc(NCc3ccc(N)cc3)c3cc(Cl)ccc3n2)CC1 CHEMBL489271 pKi 2.692 nM
CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)c1c[nH]c3ccccc13)C2 CHEMBL56564 Ki 2.7 nM
CC(C)n1ncc(-c2ccc(OCCCN3CCC[C@H]3C)cc2)cc1=O CHEMBL1958322 Ki 2.7 nM
O=C(OC1CC2COCC(C1)N2)c1cn(-c2ccsn2)c2ccccc12 CHEMBL3933042 IC50 2.71 nM
Cc1cc(C)n2c1C=C1C=CC(NCC(=O)NCCCn3nc(C(=O)N[C@H]4C[C@H]5CCC[C@@H](C4)N5C)c4ccccc43)=[N+]1[B-]2(F)F CHEMBL3084719 Ki 2.8 nM
C[C@@H]1CCCN1CCCOc1ccc(-c2cn[nH]c(=O)c2)cc1 CHEMBL1813065 Ki 2.8 nM
CN1CCN(c2nc(NCc3ccoc3)c3cc(Cl)ccc3n2)CC1 CHEMBL454890 pKi 2.818 nM
CN1[C@@H]2COC[C@H]1C[C@@H](OC(=O)c1cn(-c3ccccn3)c3ccccc13)C2 CHEMBL3892769 IC50 2.86 nM
N#Cc1cccc(-n2cc(C(=O)OC3CC4COCC(C3)N4)c3ccccc32)c1 CHEMBL3973438 IC50 2.89 nM
CNc1nc(N2CCN(C)CC2)nc2ccccc12 CHEMBL2169965 pKi 2.951 nM
Cc1cccnc1-n1nc(C)c(-c2ccc(OCCCN3CCC[C@H]3C)cc2)cc1=O CHEMBL1958334 Ki 3.0 nM
COc1cccc(-c2cn([C@H]3CN4CCC3CC4)nn2)c1 CHEMBL3746146 Ki 3.0 nM
c1cc2cc(-c3cn([C@H]4CN5CCC4CC5)nn3)ccc2o1 CHEMBL3747344 Ki 3.0 nM
CC(C)N1Nc2cn([C@H]3CN4CCC3CC4)c(=O)c3cccc1c23 CHEMBL3679397 Ki 3.0 nM
O=C1c2cccc3[nH]nc(c23)CCN1[C@@H]1CN2CCC1CC2 CHEMBL3679408 Ki 3.0 nM
CN(C(=O)c1cn(-c2cnsc2)c2ccccc12)C1CC2COCC(C1)N2 CHEMBL3906022 IC50 3.06 nM
O=C(OC1CC2CCC(C1)N2)c1cn(CC(F)F)c2ccccc12 CHEMBL3947310 IC50 3.09 nM
O=C1c2cccc3ccn(c23)CCN1[C@@H]1CN2CCC1CC2 CHEMBL3261479 Ki 3.1 nM
CN1C2CCC1CC(NC(=O)c1cn(CC(F)F)c3ccc(F)cc13)C2 CHEMBL3895387 IC50 3.15 nM
Cc1c(C(=O)OC2CC3CCC(C2)N3C)c2ccccc2n1CC(F)F CHEMBL3980976 IC50 3.15 nM
O=C(OC1CC2COCC(C1)N2)c1cn(-c2ncco2)c2ccccc12 CHEMBL3984662 IC50 3.219 nM
CN1C2CCCC1CC(OC(=O)c1nn(CCF)c3ccccc13)C2 CHEMBL3984661 IC50 3.25 nM
N=C(N)NCc1nc(-c2c[nH]c3ccccc23)cs1 CHEMBL40260 Ki 3.3 nM
CC(C)C[C@H]1COCCN1c1nc2c(C(=O)N[C@@H]3C[C@H]4CCC[C@@H](C3)N4C)cccc2o1 CHEMBL3084767 Ki 3.5 nM
CN1C2CCC1CC(OC(=O)c1cn(CC(F)F)c3ncccc13)C2 CHEMBL3915317 IC50 3.59 nM
CC(C)n1nc2c3c(cccc31)C(=O)N([C@H]1CN3CCC1CC3)C2 CHEMBL1643888 Ki 3.6 nM
N#Cc1cc(-n2cc(C(=O)O[C@H]3C[C@H]4COC[C@@H](C3)N4)c3ccccc32)ccn1 CHEMBL3966403 IC50 3.68 nM
c1ccc2nc(N3CCNCC3)ccc2c1 CHEMBL18772 Ki 3.7 nM
Cc1ccc(Sc2ccccc2N2CCNCC2)c(C)c1 CHEMBL2204360 Ki 3.7 nM
Cc1ccc(Sc2ccccc2N2CCNCC2)c(C)c1 CHEMBL2104993 Ki 3.7 nM
O=C(OC1CC2CCC(C1)N2)c1cn(CC(F)(F)F)c2ccccc12 CHEMBL3894276 IC50 3.71 nM
c1ccc(-c2ccnc(NC3=NC[C@@]4(CN5CCC4CC5)O3)n2)cc1 CHEMBL4098776 IC50 3.8 nM
O=C(OC1CC2COCC(C1)N2)c1cn(-c2ncccn2)c2ccccc12 CHEMBL3920451 IC50 3.88 nM
CCC[C@H]1COCCN1c1nc2c(C(=O)N[C@@H]3C[C@H]4CCC[C@@H](C3)N4C)cccc2o1 CHEMBL3084765 Ki 3.9 nM
Clc1cccc2c1nc1n2C[C@@]2(CN3CCC2CC3)O1 CHEMBL4204902 IC50 4.0 nM
CN1C2CCC1CC(NC(=O)c1cn(S(C)(=O)=O)c3ccc(F)cc13)C2 CHEMBL3895876 IC50 4.06 nM
O=C(NC1CC2COCC(C1)N2)c1nn(CC(F)F)c2ccccc12 CHEMBL3940685 IC50 4.09 nM
CN1C2CCC1CC(OC(=O)c1nn(CC(F)(F)F)c3ccccc13)C2 CHEMBL3977239 IC50 4.39 nM
O=C1c2cccc3[nH]nc(c23)CN1[C@H]1CN2CCC1CC2 CHEMBL1643881 Ki 4.4 nM
CC[C@H]1COCCN1c1nc2c(C(=O)N[C@@H]3C[C@H]4CCC[C@@H](C3)N4C)cccc2o1 CHEMBL3084764 Ki 4.6 nM
CN1CCN(c2cnc3ccccc3n2)CC1 CHEMBL123137 pKi 4.677 nM
Nc1nc2c(C(=O)N[C@@H]3CN4CCC3CC4)cc(Cl)cc2o1 CHEMBL1272232 Ki 4.7 nM
Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCCC2 CHEMBL1278088 Ki 4.72 nM
Cc1n[nH]c(=O)cc1-c1ccc(OCCCN2CCCCCC2)cc1 CHEMBL1958325 Ki 4.8 nM
CS(=O)(=O)n1cc(C(=O)NC2CC3COCC(C2)N3)c2cc(F)ccc21 CHEMBL3928064 IC50 4.81 nM
O=C1c2cccc3[nH]nc(c23)CN1[C@@H]1CN2CCC1CC2 CHEMBL1643882 Ki 4.9 nM
CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 CHEMBL4128926 IC50 4.9 nM
Cc1ccc2oc(N3CCN4CCC3CC4)nc2n1 CHEMBL604798 IC50 5.0 nM
CC(C)[C@H]1COCCN1c1nc2c(C(=O)N[C@@H]3C[C@H]4CCC[C@@H](C3)N4C)cccc2o1 CHEMBL3084766 Ki 5.0 nM
c1cc2c(NC3=NC[C@@]4(CN5CCC4CC5)O3)nccn2c1 CHEMBL3963469 IC50 5.0 nM
O=c1c2cccc3c2c(cn1[C@@H]1CN2CCC1CC2)NN3 CHEMBL3679392 Ki 5.0 nM
O=c1c2cccc3c2c(cn1[C@H]1CN2CCC1CC2)NN3 CHEMBL3679391 Ki 5.0 nM
O=c1c2cccc3c2c(cn1[C@H]1CN2CCC1CC2)NN3Cc1ccccc1 CHEMBL3679400 Ki 5.0 nM
Cc1cn2c3c(cccc13)C(=O)N([C@@H]1CN3CCC1CC3)CC2 CHEMBL3673238 Ki 5.0 nM
COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 CHEMBL27846 Log Ki 5.012 nM
Fc1ccc(Cn2c(N3CCNCC3)nc3ccccc32)cc1 CHEMBL302743 Ki 5.21 nM
O=c1cc(-c2ccc(OCCCN3CCCCCC3)cc2)cnn1-c1ccccn1 CHEMBL1958330 Ki 5.3 nM
O=C(N[C@H]1CN2CCC1CC2)c1c[nH]c2ccsc2c1=O CHEMBL1643880 EC50 5.4 nM
CN1C2CCCC1CC(NC(=O)c1cn(CC(F)F)c3ccc(F)cc13)C2 CHEMBL3914825 IC50 5.45 nM
CN1C2CCC1CC(OC(=O)c1cn(CC(F)(F)F)c3ncccc13)C2 CHEMBL3925327 IC50 5.56 nM
Cc1c(N2CCN(C)CC2)nc2ccccc2c1C(=O)NCCCCCCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL195241 Ki 5.6 nM
CC(C)S(=O)(=O)n1cc(C(=O)OC2CC3COCC(C2)N3)c2cc(F)ccc21 CHEMBL3945299 IC50 5.61 nM
O=C1c2cccc3[nH]c(=O)n(c23)CCN1[C@@H]1CN2CCC1CC2 CHEMBL3261486 Ki 5.7 nM
CNc1nc(N2CCN(C)CC2)cc2ccccc12 CHEMBL2169971 pKi 5.888 nM
N#Cc1ccc(-n2cc(C(=O)OC3CC4COCC(C3)N4)c3ccccc32)cc1 CHEMBL3895877 IC50 5.914 nM
O=C1c2cc(F)cc3cnn(c23)CCN1C1CN2CCC1CC2 CHEMBL3673241 Ki 6.0 nM
Cc1ccc2nc3n(c2c1)C[C@@]1(CN2CCC1CC2)O3 CHEMBL4209782 IC50 6.0 nM
Clc1ccc2c(c1)nc1n2C[C@@]2(CN3CCC2CC3)O1 CHEMBL4206339 IC50 6.0 nM
O=C1c2cc(F)cc3cnn(c23)CCN1[C@@H]1CN2CCC1CC2 CHEMBL3261482 Ki 6.4 nM
CN1CCN(c2nc(N(C)C)c3cc(Cl)ccc3n2)CC1 CHEMBL489060 pKi 6.607 nM
C[C@H]1COC[C@H](C)N1c1nc2c(C(=O)N[C@@H]3CN4CCC3CC4)cccc2o1 CHEMBL1271790 Ki 6.8 nM
CN1[C@@H]2CC[C@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2 CHEMBL1365455 IC50 6.9 nM
CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1 CHEMBL470432 pIC50 6.918 nM
Clc1cnn2ccc(NC3=NC[C@@]4(CN5CCC4CC5)O3)nc12 CHEMBL3917985 IC50 7.0 nM
Cc1cn2cccc2c(NC2=NC[C@@]3(CN4CCC3CC4)O2)n1 CHEMBL3901366 IC50 7.0 nM
c1ccc2sc(NC3=NCC4(CN5CCCC4C5)O3)nc2c1 CHEMBL3950038 IC50 7.0 nM
O=c1c2cccc3c2c(cn1[C@@H]1CN2CCC1CC2)NN3c1ccc(F)cc1 CHEMBL3679402 Ki 7.0 nM
Cc1cccc2c1nc1n2C[C@@]2(CN3CCC2CC3)O1 CHEMBL4202588 IC50 7.0 nM
O=C1c2cccc3c2c(nn3Cc2ccccc2)CN1[C@H]1CN2CCC1CC2 CHEMBL1643890 Ki 7.1 nM
CN1[C@H]2CCC[C@H]1CC(NC(=O)c1nn(C)c3ccc(O)cc13)C2 CHEMBL598804 Ki 7.3 nM
CCN(CC)c1ccc2cc(C(=O)NCCCCn3nc(C(=O)N[C@@H]4C[C@H]5CCC[C@@H](C4)N5C)c4ccccc43)c(=O)oc2c1 CHEMBL3084433 Ki 7.3 nM
Cc1ccc(Sc2ccccc2N2CCNCC2)c(Cl)c1 CHEMBL2204363 Ki 7.3 nM
CN1CCN(c2ncc3cc(Cl)ccc3n2)CC1 CHEMBL2169890 pKi 7.413 nM
c1ccc(CCn2c(N3CCNCC3)nc3ccccc32)cc1 CHEMBL305582 Ki 7.43 nM
CS(=O)(=O)n1cc(C(=O)OC2CC3COCC(C2)N3)c2cc(F)ccc21 CHEMBL3913903 IC50 7.72 nM
O=c1cc(-c2ccc(OCCCN3CCCCC3)cc2)cnn1-c1ccccn1 CHEMBL1958329 Ki 7.8 nM
O=C1c2cccc3c2c(nn3-c2ccc(F)cc2)CN1[C@@H]1CN2CCC1CC2 CHEMBL1643892 Ki 7.9 nM
Cc1n[nH]c(=O)cc1-c1ccc(OCCCN2CCCCC2)cc1 CHEMBL1958324 Ki 7.9 nM
c1ccc(CCCn2c(N3CCNCC3)nc3ccccc32)cc1 CHEMBL304534 Ki 7.96 nM
c1ccc2nc(NC3=NC[C@@]4(CN5CCC4CC5)O3)ccc2c1 CHEMBL3984925 IC50 8.0 nM
Cn1cc2c3c(cccc31)C(=O)N([C@H]1CN3CCC1CC3)CC2 CHEMBL3679416 Ki 8.0 nM
O=C1c2cccc3cnn(c23)CCN1[C@@H]1CN2CCC1CC2 CHEMBL3261481 Ki 8.0 nM
O=C1c2cccc3c2c(cn3Cc2ccc(CO)cc2)CCN1CC12CCN(CC1)CC2 CHEMBL3673249 Ki 8.0 nM
Cn1ncc(-c2ccc(OCCCN3CCCCCC3)cc2)cc1=O CHEMBL1958135 Ki 8.1 nM
CN1C2CCCC1CC(OC(=O)c1cn(CC(F)(F)F)c3ncccc13)C2 CHEMBL3981422 IC50 8.2 nM
CN1[C@@H]2CCC[C@H]1C[C@H](NC(=O)c1cccc3oc(C4CC4)nc13)C2 CHEMBL3084778 Ki 8.3 nM
CN1[C@@H]2CCC[C@H]1C[C@H](NC(=O)c1nn(CCCNc3ccc([N+](=O)[O-])c4nonc34)c3ccccc13)C2 CHEMBL3084438 Ki 8.7 nM
Cc1nn(C)c(=O)cc1-c1ccc(OCCCN2CCCCC2)cc1 CHEMBL1958327 Ki 8.9 nM
CC(C)c1ccnc(NC2=NC[C@@]3(CN4CCC3CC4)O2)n1 CHEMBL4095046 IC50 9.0 nM
Clc1ccc2nc3n(c2c1)C[C@@]1(CN2CCC1CC2)O3 CHEMBL4218050 IC50 9.0 nM
CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1 CHEMBL128 IC50 9.3 nM
CN1C2CCCC1CC(NC(=O)c1cn(CC(F)F)c3ncccc13)C2 CHEMBL3896879 IC50 10.5 nM
C[C@H]1CCCN1CCCOc1ccc(-c2cnn(-c3ccccn3)c(=O)c2)cc1 CHEMBL1958328 Ki 11.0 nM
c1ccc(-c2csc(NC3=NCC4(CN5CCC4CC5)O3)n2)cc1 CHEMBL3974854 IC50 11.0 nM
Clc1cccc2nc3n(c12)C[C@@]1(CN2CCC1CC2)O3 CHEMBL4218598 IC50 11.0 nM
COc1ccc2c(c1)nc1n2C[C@@]2(CN3CCC2CC3)O1 CHEMBL4211315 IC50 11.0 nM
FC(F)(F)c1cccc2c1nc1n2C[C@@]2(CN3CCC2CC3)O1 CHEMBL4216282 IC50 11.0 nM
CC(C)CS(=O)(=O)n1cc(C(=O)OC2CC3COCC(C2)N3)c2ccccc21 CHEMBL3960181 IC50 11.7 nM
Cc1[nH]cnc1Cc1nc(-c2c[nH]c3ccccc23)cs1 CHEMBL290938 Ki 12.0 nM
c1cnc2c(c1)C[C@@]1(CN3CCC1CC3)O2 CHEMBL2151437 Ki 12.0 nM
COc1ccc(Sc2ccccc2N2CCNCC2)c(Cl)c1 CHEMBL2204361 Ki 12.0 nM
O=C(NC1CN2CCC1CC2)c1cc(Cl)cn2ccnc12 CHEMBL4468363 Ki 12.0 nM
CN1CCN(c2nc(N)c3cc(Cl)ccc3n2)CC1 CHEMBL473302 pKi 12.02 nM
CCN(CC)c1nc2c(C(=O)N[C@@H]3CN4CCC3CC4)cccc2o1 CHEMBL1272122 Ki 12.4 nM
CN1CCN(c2nc3ccccc3nc2O)CC1 CHEMBL414183 pKi 12.59 nM
CN1C2CCCC1CC(NC(=O)c1cn(S(C)(=O)=O)c3ccc(F)cc13)C2 CHEMBL3938530 IC50 12.79 nM
C[C@H]1COCCN1c1nc2c(C(=O)N[C@@H]3C[C@H]4CCC[C@@H](C3)N4C)cccc2o1 CHEMBL3084762 Ki 12.9 nM
Cn1ncc(-c2ccc(OCCCN3CCCCC3)cc2)cc1=O CHEMBL1958134 Ki 13.0 nM
c1ccc2oc(N3CCN4CCC3CC4)nc2c1 CHEMBL611082 Ki 13.0 nM
COc1cccc2sc(NC3=NCC4(CN5CCC4CC5)O3)nc12 CHEMBL3961219 IC50 13.0 nM
CN1CC2CCCC1CC(N1Cc3cn(C)c4cccc(c34)C1=O)C2 CHEMBL3679403 Ki 13.0 nM
O=C1c2cccc3c2c(cn3Cc2ccccc2)CCN1[C@H]1CN2CCC1CC2 CHEMBL3679417 Ki 13.0 nM
O=C(OC1CC2COCC(C1)N2CCF)c1cn(CC(F)(F)F)c2ccc(F)cc12 CHEMBL3962958 IC50 13.0 nM
Cc1ccc2c(c1)nc1n2C[C@@]2(CN3CCC2CC3)O1 CHEMBL4207475 IC50 13.0 nM
CNc1cc(N2CCN(C)CC2)nc2ccccc12 CHEMBL2169969 pKi 13.49 nM
COc1cc2c3c(cnn3CCN([C@@H]3CN4CCC3CC4)C2=O)c1 CHEMBL3261485 Ki 13.5 nM
Nc1nc2c(C(=O)N[C@@H]3CN4CCC3CC4)cccc2o1 CHEMBL1272178 Ki 13.8 nM
CN1CCN(c2nc(NCc3ccccc3)c3cc(Cl)ccc3n2)CC1 CHEMBL490071 pKi 13.8 nM
O=C1c2cc(CO)cc3cnn(c23)CCN1C1CN2CCC1CC2 CHEMBL3673242 Ki 14.0 nM
O=C(OC1CC2COCC(C1)N2CCF)c1cn(CC(F)F)c2ccc(F)cc12 CHEMBL3910917 IC50 14.41 nM
CN1CCN(c2nc(NCCO)c3cc(Cl)ccc3n2)CC1 CHEMBL489664 pKi 14.79 nM
COc1ccccc1-c1nc2c(C(=O)N[C@@H]3C[C@H]4CCC[C@@H](C3)N4C)cccc2o1 CHEMBL3084777 Ki 14.9 nM
c1ccc(NC2=NC[C@@]3(CN4CCC3CC4)O2)nc1 CHEMBL3898922 IC50 15.0 nM
c1ccc2c(c1)nc1n2C[C@@]2(CN3CCC2CC3)O1 CHEMBL4215131 IC50 15.0 nM
CN1[C@@H]2CCC[C@H]1C[C@H](NC(=O)c1cccc3oc(-c4ccccc4)nc13)C2 CHEMBL3084779 Ki 15.1 nM
Cc1cccc2c(=O)n(N)c(CCCCN3CCN(c4ccc5ccccc5n4)CC3)nc12 CHEMBL1278087 IC50 15.6 nM
c1ccc(NC2=NCC3(CN4CCC3CC4)O2)nc1 CHEMBL3927589 IC50 16.0 nM
CN1C(=O)COc2c(C(=O)NC3CN4CCC3CC4)cc(Cl)cc21 CHEMBL1598608 AC50 16.2 nM
CN1[C@@H]2CCC[C@H]1C[C@H](NC(=O)c1cccc3oc(-c4ccc(F)cc4)nc13)C2 CHEMBL3084780 Ki 16.3 nM
C[C@H]1CNCCN1c1nc2c(C(=O)N[C@@H]3C[C@H]4CCC[C@@H](C3)N4C)cccc2o1 CHEMBL3084773 Ki 16.5 nM
COc1cc(C)ccc1Sc1ccccc1N1CCNCC1 CHEMBL2204362 Ki 17.0 nM
FC(F)(F)c1ccc2nc3n(c2c1)C[C@@]1(CN2CCC1CC2)O3 CHEMBL4203125 IC50 17.0 nM
COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(C[C@@H]2CCCC[C@@]2(O)c2cccc(O)c2)C[C@H]1OC CHEMBL585567 IC50 18.0 nM
CN1[C@@H]2CCC[C@H]1C[C@H](NC(=O)c1cccc3oc(-c4ccc(Cl)cc4)nc13)C2 CHEMBL3084781 Ki 18.0 nM
CN(C)c1nc2c(C(=O)N[C@@H]3CN4CCC3CC4)cccc2o1 CHEMBL1272176 Ki 18.2 nM
CNc1nc(N2CCCN(C)CC2)nc2ccc(Cl)cc12 CHEMBL511699 pKi 18.2 nM
COc1ccc(-c2nc3c(C(=O)N[C@@H]4C[C@H]5CCC[C@@H](C4)N5C)cccc3o2)cc1 CHEMBL3084782 Ki 18.8 nM
O=c1cc(-c2ccc(OCCCN3CCCCC3)cc2)cn[nH]1 CHEMBL1958132 Ki 19.0 nM
COc1ccc2sc(NC3=NCC4(CN5CCC4CC5)O3)nc2c1 CHEMBL3981300 IC50 19.0 nM
c1ccc2[nH]c(N3CCNCC3)nc2c1 CHEMBL292066 Ki 19.21 nM
c1ccc2sc(NC3=NCC4(CN5CCC4CC5)O3)nc2c1 CHEMBL3954179 IC50 21.0 nM
c1ccc2sc(NC3=NC[C@@]4(CN5CCC4CC5)O3)nc2c1 CHEMBL3970846 IC50 21.0 nM
CC(=O)N1CCc2c(sc3nc(CCCCN4CCN(c5ccc6ccccc6n5)CC4)n(N)c(=O)c23)C1 CHEMBL1276922 IC50 22.1 nM
c1ccc2nc(NC3=NC[C@@]4(CN5CCC4CC5)O3)ncc2c1 CHEMBL4071859 IC50 23.0 nM
COc1ccnc(NC2=NC[C@@]3(CN4CCC3CC4)O2)n1 CHEMBL4074583 IC50 23.0 nM
O=C1c2cccc3c2c(nn3-c2ccc(F)cc2)CN1[C@H]1CN2CCC1CC2 CHEMBL1643891 Ki 23.4 nM
NCC(O)c1ccc(O)cc1 CHEMBL53929 EC50 24.0 nM
O=C1c2cccc3[nH]nc(c23)CN1CC1CN2CCC1CC2 CHEMBL3673252 Ki 24.0 nM
O=C(NC1CC2COCC(C1)N2)c1cn(CC(F)F)c2ncc(F)cc12 CHEMBL3930754 IC50 24.1 nM
O=c1[nH]c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c1CCCC2 CHEMBL1277006 IC50 24.6 nM
c1csc(NC2=NCC3(CN4CCC3CC4)O2)n1 CHEMBL3902912 IC50 25.0 nM
O=C1c2cccc3c2c(cn3S(=O)(=O)c2ccccc2)CCN1[C@@H]1CN2CCC1CC2 CHEMBL3679420 Ki 25.0 nM
Cc1ccnc(NC2=NC[C@@]3(CN4CCC3CC4)O2)n1 CHEMBL4084852 IC50 25.0 nM
Clc1ccc(Sc2ccccc2N2CCNCC2)c(Cl)c1 CHEMBL2204359 Ki 26.0 nM
c1ccc2sc(NC3=NCC4(CN5CCC4CC5)N3)nc2c1 CHEMBL4080813 IC50 26.0 nM
c1ccc2oc(NC3=NCC4(CN5CCC4CC5)N3)nc2c1 CHEMBL4104136 IC50 26.0 nM
Cc1cn2c(N)c(Cl)cc(C(=O)NCC3CCNCC3)c2n1 CHEMBL4533922 Ki 26.0 nM
COc1cccc2c1c(C(=O)NC1C[C@@H]3CCC[C@@H](C1)N3C)nn2C CHEMBL596952 Ki 26.3 nM
Cc1sc2nc(CCCCN3CCN(c4ccc5ccccc5n4)CC3)n(N)c(=O)c2c1C CHEMBL1277559 IC50 26.7 nM
Cc1ccc(Sc2ccccc2N2CCCNCC2)c(C)c1 CHEMBL2205034 Ki 27.0 nM
c1cnc(NC2=NC[C@@]3(CN4CCC3CC4)O2)nc1 CHEMBL4100355 IC50 27.0 nM
Cc1cccc(Sc2ccccc2N2CCNCC2)c1C CHEMBL2204357 Ki 29.0 nM
O=c1c2cccc3c2c(cn1[C@H]1CN2CCC1CC2)NN3c1ccc(F)cc1 CHEMBL3679401 Ki 29.0 nM
Cc1cncc(NC2=NC[C@@]3(CN4CCC3CC4)O2)n1 CHEMBL4083246 IC50 29.0 nM
O=C1c2cccc3[nH]cc(c23)CCN1CC12CCN(CC1)CC2 CHEMBL3673250 Ki 30.0 nM
COc1ccc(Sc2ccccc2N2CCNCC2)c(OC)c1 CHEMBL2204358 Ki 32.0 nM
Cc1ccccc1Sc1ccccc1N1CCNCC1 CHEMBL2205051 Ki 32.0 nM
N=C(N)Nc1cccc(Cl)c1 CHEMBL13823 Ki 32.0 nM
O=C1c2cccc3ncn(c23)CCN1[C@@H]1CN2CCC1CC2 CHEMBL3673245 Ki 32.0 nM
O=C(N[C@@H]1CN2CCC1CC2)c1cccc2oc(C3CC3)nc12 CHEMBL1272072 Ki 32.7 nM
Cc1ccc(Sc2ccccc2N2CCNCC2)cc1C CHEMBL2205054 Ki 33.0 nM
Cc1[nH]c2ccc(Cl)cc2c1C1=CCNCC1 CHEMBL364005 IC50 34.0 nM
NC1=Nc2ccc(Cl)cc2CN1 CHEMBL2436555 Ki 34.0 nM
CN1Nc2cn(C3CC4CCCC(C3)N4C)c(=O)c3cccc1c23 CHEMBL3679407 Ki 34.0 nM
O=C(NC1CC2COCC(C1)N2)c1cn(CC(F)(F)F)c2ncc(F)cc12 CHEMBL3920500 IC50 34.13 nM
c1cc2c(NC3=NC[C@@]4(CN5CCC4CC5)O3)ncnn2c1 CHEMBL3957600 IC50 35.0 nM
c1ccc2sc(NC3=NCC4(CN5CCC4C5)O3)nc2c1 CHEMBL3923346 IC50 35.0 nM
C[C@@H]1CN(c2nc3c(C(=O)N[C@@H]4C[C@H]5CCC[C@@H](C4)N5C)cccc3o2)C[C@H](C)O1 CHEMBL3084771 Ki 35.3 nM
Clc1ccc(Sc2ccccc2N2CCNCC2)cc1 CHEMBL2205043 Ki 36.0 nM
COc1ccc(Sc2ccccc2N2CCNCC2)cc1 CHEMBL2205042 Ki 36.0 nM
CCNc1nc2c(C(=O)N[C@@H]3CN4CCC3CC4)cccc2o1 CHEMBL1272121 Ki 36.4 nM
CNc1nc2c(C(=O)N[C@@H]3CN4CCC3CC4)cccc2o1 CHEMBL1272177 Ki 36.4 nM
C[C@@H]1CNC[C@H](C)N1c1nc2c(C(=O)N[C@@H]3C[C@H]4CCC[C@@H](C3)N4C)cccc2o1 CHEMBL3084774 Ki 37.3 nM
Clc1cccc2sc(NC3=NCC4(CN5CCC4CC5)N3)nc12 CHEMBL4063687 IC50 38.0 nM
CN1[C@@H]2CCC[C@H]1C[C@H](NC(=O)c1cccc3oc(N4CCOCC4)nc13)C2 CHEMBL3084761 Ki 40.0 nM
CN1[C@@H]2CCC[C@H]1C[C@H](NC(=O)c1cccc3nc(-c4ccccc4)oc13)C2 CHEMBL3084783 Ki 40.4 nM
Nn1c(SCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2sc3c(c2c1=O)CCCC3 CHEMBL1277099 IC50 41.4 nM
CN1C(Nc2nc3ccccc3s2)=NCC12CN1CCC2CC1 CHEMBL4060728 IC50 43.0 nM
Brc1nc2n(c1Br)C[C@@]1(CN3CCC1CC3)O2 CHEMBL4209536 IC50 43.0 nM
O=c1[nH]c(SCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2sc3c(c12)CCCC3 CHEMBL1277187 IC50 44.2 nM
Cc1ccc(Sc2cc(C)ccc2N2CCNCC2)c(C)c1 CHEMBL2205031 Ki 45.0 nM
Cc1ccc2nc(CCCCN3CCN(c4ccc5ccccc5n4)CC3)n(N)c(=O)c2c1 CHEMBL1277996 IC50 45.6 nM
Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2ccccc2c1=O CHEMBL1277651 IC50 45.7 nM
Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CC(O)CC2 CHEMBL1276921 IC50 46.5 nM
CN1CCN(c2nc3ccccc3c(=O)[nH]2)CC1 CHEMBL2169964 pKi 46.77 nM
COc1ccccc1-c1nc2c(C(=O)N[C@@H]3CN4CCC3CC4)cccc2o1 CHEMBL1272016 Ki 47.3 nM
CC1CCc2nc(CCCCN3CCN(c4ccc5ccccc5n4)CC3)n(N)c(=O)c2C1 CHEMBL1278175 IC50 48.3 nM
Cc1sc2nc(SCCCN3CCN(c4ccc5ccccc5n4)CC3)n(N)c(=O)c2c1C CHEMBL1276832 IC50 48.4 nM
O=C1c2cccc3[nH]cc(c23)CCN1[C@H]1CN2CCC1CC2 CHEMBL3679415 Ki 49.0 nM
O=C(NC1CN2CCC1CC2)c1cc2ccccc2s1 CHEMBL365323 Ki 49.8 nM
c1nc(NC2=NC[C@@]3(CN4CCC3CC4)O2)c2sccc2n1 CHEMBL3928422 IC50 50.0 nM
Cc1sc2nc(SCCCN3CCN(c4cc(C)c5ccccc5n4)CC3)n(N)c(=O)c2c1C CHEMBL1276833 IC50 50.5 nM
Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2cccc(F)c2c1=O CHEMBL1277652 IC50 50.6 nM
COc1ccc2sc(NC3=NCC4(CN5CCC4CC5)N3)nc2c1 CHEMBL4085299 IC50 51.0 nM
COc1ccccc1Sc1ccccc1N1CCNCC1 CHEMBL2205050 Ki 52.0 nM
c1cc2cc(-c3cn(C4CN5CCC4CC5)nn3)ccc2[nH]1 CHEMBL3746799 Ki 52.0 nM
Nn1c(CCCCN2CCN(c3nc4ccccc4cc3O)CC2)nc2c(c1=O)CCCC2 CHEMBL1277282 IC50 52.6 nM
Fc1ccc(Sc2ccccc2N2CCNCC2)cc1 CHEMBL2205044 Ki 53.0 nM
Nc1cc2c(cc1Cl)C(=O)NC1CCN(CCOCCO2)CC1 CHEMBL116913 Ki 53.2 nM
c1cc2occc2c(NC2=NC[C@@]3(CN4CCC3CC4)O2)n1 CHEMBL3937435 IC50 54.0 nM
Nn1c(CCCCN2CCN(c3ccc4ccc(O)cc4n3)CC2)nc2c(c1=O)CCCC2 CHEMBL1277373 IC50 55.2 nM
Cc1ccc(Sc2ccccc2N2CCNCC2)cc1 CHEMBL2205045 Ki 56.0 nM
COc1ccc(N2Nc3cn([C@H]4CN5CCC4CC5)c(=O)c4cccc2c34)cc1 CHEMBL3679405 Ki 57.0 nM
CN1CCN(c2nc3ncc(Cl)cc3n3cnnc23)CC1 CHEMBL4797517 IC50 57.0 nM
COc1ccc(-c2nc3cccc(C(=O)N[C@@H]4C[C@H]5CCC[C@@H](C4)N5C)c3o2)cc1 CHEMBL3084760 Ki 58.5 nM
CN1Nc2cn(C3CC4CCC(C3)N4C)c(=O)c3cccc1c23 CHEMBL3679419 Ki 59.0 nM
Cc1cc(N2CCN(CCCCc3nc4c(c(=O)n3N)CCCC4)CC2)nc2ccccc12 CHEMBL1277007 IC50 59.1 nM
Cn1nc(C(=O)NC2C[C@@H]3CCC[C@@H](C2)N3Cc2ccccc2)c2ccccc21 CHEMBL597984 Ki 59.3 nM
C[C@@H]1CNC[C@@H](C)N1c1nc2c(C(=O)N[C@@H]3C[C@H]4CCC[C@@H](C3)N4C)cccc2o1 CHEMBL3084775 Ki 59.4 nM
COc1ccccc1-c1cccc2cc(C(=O)N[C@H]3CN4CCC3CC4)oc12 CHEMBL2151440 Ki 60.0 nM
Nn1c(SCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2cccnc2c1=O CHEMBL1277372 IC50 61.0 nM
COc1cccc(Sc2ccccc2N2CCNCC2)c1 CHEMBL2205048 Ki 62.0 nM
Brc1nc2n(c1Br)CC1(CN3CCC1CC3)O2 CHEMBL4204677 IC50 62.0 nM
Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCC2 CHEMBL1276834 IC50 62.1 nM
Clc1cccc(COc2cncc(N3CCNCC3)n2)c1 CHEMBL4743049 Ki 63.69 nM
Nn1c(SCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCCC2 CHEMBL1277281 IC50 63.8 nM
Cc1cccc(Sc2ccccc2N2CCNCC2)c1 CHEMBL2205049 Ki 64.0 nM
c1ccc(Sc2ccccc2N2CCNCC2)cc1 CHEMBL2205041 Ki 64.0 nM
Nn1c(SCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2ncccc2c1=O CHEMBL1277462 IC50 64.8 nM
CC(C)N(C)c1nc2c(C(=O)N[C@@H]3CN4CCC3CC4)cccc2o1 CHEMBL1272123 Ki 66.5 nM
Clc1cccc(Sc2ccccc2N2CCNCC2)c1Cl CHEMBL2204356 Ki 67.0 nM
O=C1c2cccc3ccn(c23)CCN1[C@H]1CN2CCC1CC2 CHEMBL3261478 Ki 67.6 nM
O=c1c2cccc3c2c(cn1[C@H]1CN2CCC1CC2)NN3c1ccc(Cl)cc1 CHEMBL3679404 Ki 68.0 nM
Nn1c(SCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2ccccc2c1=O CHEMBL1277280 IC50 69.9 nM
Cc1nc2nc(N3CCN4CCC3CC4)oc2cc1Cl CHEMBL603052 IC50 70.0 nM
COc1cccc2c(C(=O)NC3C[C@@H]4CCC[C@@H](C3)N4C)nn(C)c12 CHEMBL599012 Ki 71.1 nM
CN1[C@@H]2CCC[C@H]1C[C@H](NC(=O)c1cccc3oc(N4CCNCC4)nc13)C2 CHEMBL3084772 Ki 72.2 nM
O=C1c2cccc3cnn(c23)CCN1CC12CCN(CC1)CC2 CHEMBL3673253 Ki 73.0 nM
CN1[C@@H]2CCC[C@H]1C[C@H](NC(=O)c1cccc3nc(-c4ccc(Cl)cc4)oc13)C2 CHEMBL3084759 Ki 73.8 nM
C[C@@H]1SC(c2ccccc2)=N[C@@H]1Cc1c[nH]cn1 CHEMBL4204036 Ki 77.0 nM
CC(=O)N1CCc2c(sc3nc(SCCCN4CCN(c5ccc6ccccc6n5)CC4)n(N)c(=O)c23)C1 CHEMBL1277558 IC50 77.6 nM
CN1CCN(c2nc(NCCc3ccccc3)c3cc(Cl)ccc3n2)CC1 CHEMBL490072 pKi 79.43 nM
COc1cccc(Sc2ccccc2N2CCNCC2)c1OC CHEMBL2204355 Ki 80.0 nM
CN(C)c1ccc2c(-c3ccc(C(=O)NCCCCCNC(=O)CCn4cc(CCN)c5cc(O)ccc54)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1 CHEMBL2322133 Kd 83.0 nM
Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(Cl)cccc2c1=O CHEMBL1277914 IC50 83.1 nM
Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCCCC2 CHEMBL1276835 IC50 84.8 nM
c1ccc(-c2ccnc(NC3=NC[C@@]4(CN5CCC4CC5)O3)c2)cc1 CHEMBL3926969 IC50 85.0 nM
COc1ccc(Sc2ccccc2N2CCNCC2)cc1OC CHEMBL2205052 Ki 86.0 nM
Nn1c(CN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCCC2 CHEMBL1277374 IC50 86.6 nM
Cc1sc2nc(SCCCN3CCN(c4nc5ccccc5s4)CC3)n(N)c(=O)c2c1C CHEMBL1276920 IC50 87.6 nM
C[C@@H]1COCCN1c1nc2c(C(=O)N[C@@H]3C[C@H]4CCC[C@@H](C3)N4C)cccc2o1 CHEMBL3084763 Ki 92.6 nM
CN1[C@@H]2CCC[C@H]1C[C@H](NC(=O)c1cccc3nc(-c4ccc(F)cc4)oc13)C2 CHEMBL3084784 Ki 94.9 nM
CC1CCc2c(nc(CCCCN3CCN(c4ccc5ccccc5n4)CC3)n(N)c2=O)C1 CHEMBL1278176 IC50 97.9 nM
Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2ccc(F)cc2c1=O CHEMBL1277745 IC50 99.4 nM
Nn1c(SCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2sc3c(c2c1=O)CCNC3 CHEMBL1277463 IC50 100.0 nM
Clc1cc(NC2=NC[C@@]3(CN4CCC3CC4)O2)ncn1 CHEMBL4097654 IC50 100.0 nM
O=C1c2cccc3[nH]nc(c23)CCN1[C@H]1CN2CCC1CC2 CHEMBL3679412 Ki 108.0 nM
Clc1ccc(Sc2ccccc2N2CCNCC2)cc1Cl CHEMBL2205053 Ki 110.0 nM
COc1cnc(NC2=NC[C@@]3(CN4CCC3CC4)O2)nc1 CHEMBL4089244 IC50 120.0 nM
CCN(CC)CCOC(=O)c1cc(Cl)c(N)cc1OC CHEMBL287045 pKi 125.89 nM
Cc1ccc(Sc2ccccc2N2CCN(C)CC2)c(C)c1 CHEMBL2205033 Ki 130.0 nM
CCc1nc2cccc3c2n1CCN([C@@H]1CN2CCC1CC2)C3=O CHEMBL3673246 Ki 130.0 nM
FC(F)(F)c1ccc(Sc2ccccc2N2CCNCC2)cc1 CHEMBL2205046 Ki 140.0 nM
NCCc1c[nH]c2ccc(O)cc12 CHEMBL39 EC50 141.0 nM
CCN(CC)c1ccc2cc(C(=O)NCCOCCOCCn3nc(C(=O)N[C@@H]4C[C@H]5CCC[C@@H](C4)N5C)c4ccccc43)c(=O)oc2c1 CHEMBL3084436 Ki 142.0 nM
CN1CC2CN(c3ccc(-c4ccccc4)nn3)CC2C1 CHEMBL2151443 Ki 150.0 nM
Cc1ccc(Sc2ccc(C)cc2N2CCNCC2)c(C)c1 CHEMBL2204365 Ki 150.0 nM
Cc1cc(NC2=NC[C@@]3(CN4CCC3CC4)O2)ncn1 CHEMBL4075880 IC50 150.0 nM
Cc1cnc(NC2=NC[C@@]3(CN4CCC3CC4)O2)nc1 CHEMBL4061082 IC50 150.0 nM
C[C@@H]1SC(c2ccccc2)=N[C@H]1Cc1c[nH]cn1 CHEMBL4204576 Ki 150.0 nM
O=C(N[C@H]1CN2CCC1CC2)c1ccc2ncccc2c1 CHEMBL4228983 IC50 150.0 nM
COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN2CCC[C@@H]12 CHEMBL34291 Ki 152.0 nM
CCN(CC)c1ccc2cc(C(=O)NCCCOc3cccc4c(C(=O)N[C@H]5C[C@H]6CCC[C@@H](C5)N6C)nn(C)c34)c(=O)oc2c1 CHEMBL3084442 Ki 157.0 nM
CCCCN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCCO3)CC1 CHEMBL68131 pKi 158.49 nM
COc1cccc([C@]2(O)CCCC[C@H]2CN2CC[C@@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@@H](OC)C2)c1 CHEMBL571799 IC50 159.0 nM
Cc1ccc(Sc2cccc(C)c2N2CCNCC2)c(C)c1 CHEMBL2204364 Ki 160.0 nM
O=C(N[C@@H]1CN2CCC1CC2)c1cccc2oc(N3CCOCC3)nc12 CHEMBL1271520 Ki 165.0 nM
CC(C)Nc1nc(N2CCN(C)CC2)nc2ccc(Cl)cc12 CHEMBL490073 pKi 165.96 nM
Clc1ccc2c(NC3=NC4(CO3)CN3CCC4CC3)ncnn12 CHEMBL3900048 IC50 170.0 nM
c1cnc(NC2=NCC3(CN4CCC3CC4)O2)cn1 CHEMBL4087500 IC50 170.0 nM
NC1=Nc2ccc(Cl)c(Cl)c2CN1 CHEMBL1548 Ki 172.0 nM
O=C(N[C@H]1CN2CCC1CC2)c1ccc2ccsc2c1 CHEMBL378349 Ki 174.0 nM
c1cc2c(NC3=NC[C@@]4(CN5CC[C@@H]4C5)O3)ncnn2c1 CHEMBL3909099 IC50 180.0 nM
c1cnc(NC2=NC[C@@]3(CN4CCC3CC4)O2)cn1 CHEMBL4102804 IC50 180.0 nM
CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1 CHEMBL42 Log Ki 186.21 nM
COc1ccc(Sc2ccc(C)cc2N2CCNCC2)cc1 CHEMBL2205037 Ki 190.0 nM
c1cnc2cnc(NC3=NC[C@@]4(CN5CCC4CC5)O3)cc2c1 CHEMBL4098850 IC50 190.0 nM
CCN(CC)c1ccc2cc(C(=O)NCCCn3nc(C(=O)N[C@@H]4C[C@H]5CCC[C@@H](C4)N5C)c4ccccc43)c(=O)oc2c1 CHEMBL3084431 Ki 199.0 nM
CN1CCN(c2ccc3c(N)cccc3n2)CC1 CHEMBL2169973 pKi 204.17 nM
O=C1c2cccc3ccn(c23)CCCN1[C@@H]1CN2CCC1CC2 CHEMBL3673240 Ki 205.0 nM
O=C1c2cccc3nc(-c4ccccc4Cl)n(c23)CCN1[C@@H]1CN2CCC1CC2 CHEMBL3673248 Ki 206.0 nM
CN1[C@@H]2CCC[C@H]1C[C@@H](NC(=O)c1nn(C)c3c(OCCOCCOCCNC(=S)Nc4ccc(-c5c6ccc(=O)cc-6oc6cc(O)ccc56)c(C(=O)O)c4)cccc13)C2 CHEMBL3084444 Ki 208.0 nM
CN1CCN(c2cc3ccccc3c(N)n2)CC1 CHEMBL2169972 pKi 218.78 nM
O=C(N1CCN2CCC1CC2)n1nc(-c2ccc(F)cc2)c2c1COCC2 CHEMBL5272946 IC50 224.0 nM
O=S1(=O)c2cc(N3CCN4CCC3CC4)ccc2-c2cccc(F)c21 CHEMBL3235480 Ki 230.0 nM
c1ccc(NC2=NCC3(CN4CCC3CC4)O2)cc1 CHEMBL3973872 IC50 230.0 nM
COc1ccc2c(C(=O)NC3C[C@@H]4CCC[C@@H](C3)N4C)nn(C)c2c1 CHEMBL596758 Ki 237.0 nM
C=CCn1c(N2CCNCC2)nc2ccccc21 CHEMBL68281 EC50 240.0 nM
C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1 CHEMBL4212435 Ki 240.0 nM
O=C1c2cccc3[nH]nc(c23)CCN1CC1CN2CCC1CC2 CHEMBL3673254 Ki 241.0 nM
c1cn2nc(NC3=NC[C@@]4(CN5CCC4CC5)O3)ccc2n1 CHEMBL3969845 IC50 250.0 nM
C[C@@]12CCCN1CC[C@H]2CNC(=O)c1cc(Cl)cc2nc[nH]c12 CHEMBL472219 pKi 251.19 nM
CN1CCN(c2ccc3cc(Cl)ccc3n2)CC1 CHEMBL260565 pKi 251.19 nM
Cc1ccc(Sc2ccc(C)cc2N2CCNCC2)cc1 CHEMBL2205040 Ki 260.0 nM
Cc1nn(C)c(C)c1-c1cccc2c1CC[C@H](N(C)C)C2 CHEMBL2164327 Ki 260.79 nM
CN1C2CCCC1CC(N1CCc3cn(C)c4cccc(c34)C1=O)C2 CHEMBL3679418 Ki 267.0 nM
Cc1ccc(Oc2ccccc2N2CCNCC2)c(C)c1 CHEMBL2205035 Ki 270.0 nM
COC(=O)c1c(-c2ccc(F)cc2)c(-c2ccncc2)c(N2CCNCC2)n1C CHEMBL376324 IC50 275.0 nM
CN1[C@H]2CCC[C@H]1CC(NC(=O)c1nn(C)c3cc(O)ccc13)C2 CHEMBL603673 Ki 279.0 nM
O=C(N[C@H]1CN2CCC1CC2)c1cc2cccc(Cl)c2s1 CHEMBL2151572 IC50 299.0 nM
Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 CHEMBL4877603 Ki 300.0 nM
Clc1ccc(-c2noc3c2CCNCC3)cc1 CHEMBL4218801 Ki 303.0 nM
O=C(N[C@H]1CN2CCC1CC2)c1ccc2ccoc2c1 CHEMBL379302 Ki 310.0 nM
Cc1ccc(Sc2ccccc2)c(N2CCNCC2)c1 CHEMBL2205036 Ki 310.0 nM
c1ccc2cc(OCC3CCNCC3)ccc2c1 CHEMBL453996 Ki 311.0 nM
COc1ccc2[nH]c(=O)n(C(=O)N[C@@H]3C[C@H]4CC[C@@H](C3)N4C)c2c1 CHEMBL3084582 pKi 316.23 nM
Fc1ccc2c(NC3=NC[C@@]4(CN5CCC4CC5)O3)ncnn12 CHEMBL3905979 IC50 320.0 nM
CN1CCN(c2ccc3cccc(N)c3n2)CC1 CHEMBL2169974 pKi 331.13 nM
COc1ccc(-c2nn(C(=O)N3CCN4CCC3CC4)c3c2CCOC3)cc1 CHEMBL5278405 IC50 338.0 nM
CN1CCC(=C2c3ccccc3CC(=O)c3sccc32)CC1 CHEMBL1633 Ki 338.93 nM
Clc1cnc(NC2=NC[C@@]3(CN4CCC3CC4)O2)cn1 CHEMBL4077222 IC50 350.0 nM
Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 CHEMBL519240 Ki 351.84 nM
CCc1nn2c(C)cc(C)nc2c1Cc1ccc(-c2nnc(C3CCNCC3)o2)cc1 CHEMBL3675743 Ki 360.29 nM
CN1[C@H]2CCC[C@H]1CC(NC(=O)c1nn(C)c3cccc(OCc4ccccc4)c13)C2 CHEMBL598803 Ki 375.0 nM
CN1CCN(C2=Nc3ccccc3Oc3ccc(Cl)cc32)CC1 CHEMBL831 AC50 380.0 nM
COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(C[C@H]2CCCC[C@]2(O)c2cccc(O)c2)C[C@H]1OC CHEMBL585925 IC50 390.0 nM
N#Cc1ccc2ccc(OCC3CCNCC3)cc2c1 CHEMBL444985 Ki 404.0 nM
O=C1c2cccc3nc(-c4ccccc4)n(c23)CCN1[C@@H]1CN2CCC1CC2 CHEMBL3673247 Ki 406.0 nM
CN1CCN(c2cnc3ccccc3c2)CC1 CHEMBL2169967 pKi 407.38 nM
Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc12 CHEMBL2181166 Ki 410.0 nM
O=C1c2cccc3ccn(c23)CCCN1[C@H]1CN2CCC1CC2 CHEMBL3673239 Ki 416.0 nM
Cc1ccc(-c2noc3c2CCNCC3)cc1 CHEMBL4215875 Ki 420.0 nM
COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl CHEMBL5083607 Ki 420.0 nM
Cc1ccc(Sc2ccc(F)cc2)c(N2CCNCC2)c1 CHEMBL2205039 Ki 440.0 nM
c1cc(NC2=NCC3(CN4CCC3CC4)O2)ncn1 CHEMBL4064914 IC50 440.0 nM
Fc1ccc(-c2ccc(-c3cn([C@H]4CN5CCC4CC5)nn3)s2)cn1 CHEMBL4458163 Ki 440.0 nM
CC(C)(C)c1ccc(Sc2ccccc2N2CCNCC2)cc1 CHEMBL2205047 Ki 450.0 nM
CNc1nc(N2CC(N(C)C)C2)nc2ccc(Cl)cc12 CHEMBL2169975 pKi 467.74 nM
c1ccc2cc(NC3=NC[C@@]4(CN5CCC4CC5)O3)ncc2c1 CHEMBL3918431 IC50 480.0 nM
c1ccc2sc(NC3=NC[C@@]4(CN5CC[C@@H]4C5)O3)nc2c1 CHEMBL3951064 IC50 480.0 nM
Clc1cnc2nc(N3CCN4CCC3CC4)oc2c1 CHEMBL597241 IC50 484.0 nM
Clc1ccc2c(c1)C(N1CCNCC1)=Nc1ccccc1O2 CHEMBL1113 AC50 490.0 nM
Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 CHEMBL4854605 Ki 498.0 nM
Cc1ccc(Sc2ccc(Cl)cc2)c(N2CCNCC2)c1 CHEMBL2205038 Ki 500.0 nM
CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 CHEMBL3104093 pKi 501.19 nM
O=S1(=O)c2ccc(F)cc2-c2ccc(N3CCN4CCC3CC4)cc21 CHEMBL3235482 Ki 505.0 nM
CN1CCN(c2ccc3ccccc3c2)CC1 CHEMBL2169968 pKi 537.03 nM
Cc1c(N2CCNCC2)nc2ccc(Br)cc2c1C(=O)NC[C@H](CCC(=O)O)c1ccccc1Cl CHEMBL4642079 pKi 537.03 nM
c1cc(-c2ccc(-c3cn([C@H]4CN5CCC4CC5)nn3)s2)ccc1CN1CCCCC1 CHEMBL4533685 Ki 560.0 nM
CN1CCN(c2nc(O)c3cc(Cl)ccc3n2)CC1 CHEMBL471712 pKi 575.44 nM
c1cnc2nc(N3CCN4CCC3CC4)oc2c1 CHEMBL597843 Ki 579.0 nM
O=C(N[C@H]1CN2CCC1CC2)c1ccc2occc2c1 CHEMBL378471 IC50 580.0 nM
O=C(N1CCN2CCC1CC2)n1nc(-n2cc(Cl)cn2)c2c1COCC2 CHEMBL5278640 IC50 585.0 nM
COc1ccccc1-c1cc(C2CCNC2)ccc1Cl CHEMBL5077293 Ki 590.0 nM
C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1C CHEMBL2058426 Ki 591.0 nM
Clc1cnc(NC2=NCC3(CN4CCC3CC4)N2)nc1 CHEMBL4077622 IC50 620.0 nM
c1ccc2c(CSc3[nH]cnc4ncnc3-4)cccc2c1 CHEMBL1382868 IC50 620.0 nM
CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 CHEMBL3217984 pKi 630.96 nM
CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1 CHEMBL2181170 Ki 641.0 nM
CN1C(=N)N(C)/C(=C/c2c[nH]c3cccc(Br)c23)C1=O CHEMBL2058419 Ki 656.0 nM
Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 CHEMBL4866412 Ki 656.0 nM
FC(F)(F)c1ccc2c(c1)nc1n2C[C@@]2(CN3CCC2CC3)O1 CHEMBL4214778 IC50 660.0 nM
NCCc1cn(S(=O)(=O)c2c(Cl)nc3sccn23)c2ccccc12 CHEMBL5075931 Ki 661.83 nM
Cc1ccc(Sc2c(C)cccc2N2CCNCC2)c(C)c1 CHEMBL2205032 Ki 670.0 nM
CCCN1CCC(COc2nc3ccccc3c3ncccc23)CC1 CHEMBL2181171 Ki 680.0 nM
c1nc(NC2=NC[C@@]3(CN4CCC3CC4)O2)c2ccsc2n1 CHEMBL3900472 IC50 690.0 nM
O=C(c1ccc(Cl)o1)N1CC2CNCC2C1 CHEMBL2179529 Ki 700.0 nM
O=C1c2cccc3c2N(CCN1[C@@H]1CN2CCC1CC2)S(=O)(=O)N3 CHEMBL3261487 Ki 701.0 nM
Fc1ccc(-c2noc3c2CCNCC3)cc1 CHEMBL4218672 Ki 703.0 nM
CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1 CHEMBL2181189 Ki 710.0 nM
O=C(N[C@H]1CN2CCC1CC2)c1cc2ccc3ccccc3n2c1 CHEMBL4453847 IC50 710.0 nM
Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 CHEMBL4863868 Ki 744.0 nM
CN1[C@H]2CCC[C@H]1CC(NC(=O)c1nn(C)c3cc(OCc4ccccc4)ccc13)C2 CHEMBL604083 Ki 749.0 nM
c1ccc(-c2nc(CN3CCN(c4ncccn4)CC3)c[nH]2)cc1 CHEMBL103772 Ki 750.0 nM
Brc1cnc2nc(N3CCN4CCC3CC4)oc2c1 CHEMBL611369 IC50 779.0 nM
COc1cccc([C@@]2(O)CCCC[C@@H]2CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)c1 CHEMBL569585 IC50 790.0 nM
Clc1ccc(C2CCNC2)cc1 CHEMBL27453 pKi 794.33 nM
N=C(N)NCCCc1ccccc1 CHEMBL1824047 pKi 794.33 nM
COc1ccc(Cn2c(=O)[nH]c3cc(C(=O)NCCN4CCCCC4)ccc3c2=O)cc1 CHEMBL223715 IC50 800.0 nM
Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1 CHEMBL4848305 Ki 806.0 nM
Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 CHEMBL4876193 Ki 816.0 nM
Clc1ccc(NC2=NCC3(CN4CCC3CC4)N2)nc1 CHEMBL4081582 IC50 860.0 nM
Oc1ccccc1C1=NC(Cc2c[nH]cn2)C(c2ccccc2)S1 CHEMBL4209942 Ki 860.0 nM
O=C(N[C@H]1CN2CCC1CC2)c1ccc(Cl)cc1 CHEMBL177611 Ki 930.0 nM
c1ccc2sc(NC3=NCC4(CN5CCC[C@@H]4C5)O3)nc2c1 CHEMBL3934387 IC50 950.0 nM
Oc1ccccc1C1=NC(Cc2c[nH]cn2)CS1 CHEMBL4205064 Ki 950.0 nM
O=C(O[C@@H]1C[C@@H]2C[C@H]3C[C@H](C1)N2CC3=O)c1c[nH]c2ccccc12 CHEMBL2368925 AC50 950.0 nM
COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCNCC1 CHEMBL542139 Ki 988.1 nM