C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(-c2cccc(Cl)n2)n1)C(F)(F)F CHEMBL4279047 IC50 0.04 nM
C[C@H](Nc1nc(N[C@@H](C)C(F)(F)F)nc(-c2cccc(Cl)n2)n1)C(F)(F)F CHEMBL4278845 IC50 0.25 nM
CC(Nc1nc(NC(C)C(F)(F)F)nc(-c2cccc(Cl)n2)n1)C(F)(F)F CHEMBL4283785 IC50 0.3 nM
CCc1ccc(Cl)cc1-n1c(C=C(C)C)c(C(=O)N2CCNCC2)cc(-c2nc(-c3ccc(Cl)cc3)cs2)c1=O CHEMBL4448475 EC50 0.43 nM
FC1(F)CCC(Nc2nc(NC3CCC(F)(F)C3)nc(-c3cccc(Cl)n3)n2)C1 CHEMBL4280132 IC50 0.7 nM
C[C@H](Nc1nccc(N2C(=O)OC[C@@H]2[C@H](C)F)n1)c1cn(-c2ccc(C(F)F)cc2)cn1 CHEMBL3909586 IC50 1.0 nM
N#Cc1ccnc(N2C(=O)CC[C@H]2CC(=O)N(c2cc(F)cc(F)c2)[C@H](C(=O)NC2CC(F)(F)C2)c2ccccc2Cl)c1 CHEMBL4289465 IC50 1.0 nM
N#Cc1ccnc(N2C(=O)[C@@H](O)C[C@H]2CC(=O)N(c2cc(F)cc(F)c2)[C@H](C(=O)NC2CC(F)(F)C2)c2ccccc2Cl)c1 CHEMBL4278793 IC50 1.0 nM
FC1(F)CC(Nc2nc(NC3CC(F)(F)C3)nc(-c3cccc(C(F)(F)F)n3)n2)C1 CHEMBL4280772 IC50 1.0 nM
FC1(F)CCC(Nc2nc(NC3CCC(F)(F)C3)nc(-c3cccc(C(F)(F)F)n3)n2)C1 CHEMBL4277352 IC50 1.0 nM
COc1cc2[nH]c(=O)c([C@H](C)Nc3ncc(C#N)c(OC)n3)cc2cc1Cl CHEMBL4442678 IC50 1.0 nM
CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncn3c2CCc2cc(C(F)(F)F)ccc2-3)n1 CHEMBL4444067 IC50 1.0 nM
C[C@H](Nc1nc(N2C(=O)OC[C@@H]2[C@H](C)F)c2cc[nH]c2n1)c1cn(-c2ccc(Cl)cc2)cn1 CHEMBL4463644 IC50 2.0 nM
Cc1cc([C@@H](C)Nc2nc(N3C(=O)OC[C@@H]3C(C)C)c3cc[nH]c3n2)ncc1-c1ccnc(C(F)(F)F)c1 CHEMBL4439421 IC50 2.0 nM
C[C@H](Nc1ccc(C#N)n(C)c1=O)c1cc2cc(Cl)c(OCC3CC3)cc2[nH]c1=O CHEMBL4456610 IC50 2.0 nM
C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(-c2cccc(C(F)(F)F)n2)n1)C1CC1 CHEMBL4278828 IC50 2.0 nM
C[C@H](Nc1ncc(F)c(N2C(=O)OC[C@@H]2[C@H](C)F)n1)c1ncn2c1CCc1cc(C(F)(F)F)ccc1-2 CHEMBL4529476 IC50 2.1 nM
C[C@H](Nc1nc(Cl)cc(N2C(=O)OC[C@@H]2[C@H](C)F)n1)c1ncn2c1CCc1cc(C(F)(F)F)ccc1-2 CHEMBL4548637 IC50 2.12 nM
C[C@H](Nc1nccc(N2C(=O)OC[C@@H]2[C@H](C)F)n1)c1ncn2c1COc1cc(Cl)ccc1-2 CHEMBL4469477 IC50 2.2 nM
C[C@H](Nc1nccc(N2C(=O)OC[C@@H]2[C@H](C)F)n1)c1ncn2c1CCc1cc(Cl)ccc1-2 CHEMBL4467991 IC50 2.3 nM
C[C@H](Nc1nccc(N2C(=O)OC[C@@H]2[C@H](C)F)n1)c1ncn2c1COc1cc(C(F)(F)F)ccc1-2 CHEMBL4475715 IC50 2.7 nM
C[C@H](Nc1nc(Cl)cc(N2C(=O)OCC2[C@@H](C)O)n1)c1cn(-c2ccc(Cl)cc2)cn1 CHEMBL3980822 IC50 3.0 nM
C[C@H](Nc1nc(Cl)cc(N2C(=O)OC[C@@H]2[C@@H](C)O)n1)c1cn(-c2ccc(Cl)cc2)cn1 CHEMBL3979625 IC50 3.0 nM
N#Cc1ccnc(N2C(=O)CC[C@H]2CC(=O)N(c2cncc(F)c2)[C@H](C(=O)NC2CC(F)(F)C2)c2ccccc2Cl)c1 CHEMBL4282663 IC50 3.0 nM
N#Cc1ccnc(N2C(=O)CC[C@H]2CC(=O)N(c2cccc(F)c2)[C@H](C(=O)NC2CC(F)(F)C2)c2ccccc2Cl)c1 CHEMBL4289061 IC50 3.0 nM
Cn1nccc1-c1cc2c(cc1F)Nc1ncc(F)cc1CN2C(=O)C1CCN(CC(F)(F)F)CC1 CHEMBL4436236 IC50 3.5 nM
N#Cc1ccnc(N2C(=O)CC[C@H]2C(=O)N(c2cncc(F)c2)[C@H](C(=O)NC2CC(F)(F)C2)c2ccccc2Cl)c1 CHEMBL3989958 IC50 3.5 nM
C[C@H](O)c1cccc(NC(=O)c2nn(Cc3ccc(F)cc3)c3c2CN(C(=O)c2ccc[nH]2)C[C@H]3C)c1 CHEMBL4215717 IC50 3.8 nM
C[C@H](Nc1nc(Cl)cc(N2C(=O)OC[C@@H]2[C@@H](C)O)n1)c1cnc(-c2ccc(Cl)cc2)s1 CHEMBL3962229 IC50 4.0 nM
CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(-c3ccnc(C(C)(C)C)c3)cn2)n1 CHEMBL4170686 IC50 4.0 nM
C[C@H](Nc1nccc(N2C(=O)OC[C@@H]2[C@H](C)F)n1)c1cn(-c2ccc(Cl)cc2)cn1 CHEMBL3986241 IC50 4.0 nM
C[C@H](Nc1ccc(C#N)n(C)c1=O)c1cc2cc(Cl)c(O[C@H](C)c3ccccn3)cc2[nH]c1=O CHEMBL4469055 IC50 4.0 nM
COc1cc2[nH]c(=O)c([C@H](C)Nc3ccc(C#N)n(C)c3=O)cc2cc1Cl CHEMBL4437754 IC50 4.0 nM
FC1(F)CCC(Nc2nc(NC3CCC(F)(F)CC3)nc(-c3cccc(C(F)(F)F)n3)n2)CC1 CHEMBL4288840 IC50 4.0 nM
CCC(Nc1nc(NC(CC)C2CC2)nc(-c2cccc(Cl)n2)n1)C1CC1 CHEMBL4282989 IC50 4.0 nM
COc1nc(N[C@@H](C)c2cc3cc(Cl)c(OC(C)C)cc3[nH]c2=O)ncc1C#N CHEMBL4526035 IC50 4.0 nM
C[C@H](Nc1nccc(N2C(=O)OC[C@@H]2[C@H](C)F)n1)c1ncn2c1CCc1cc(C(F)(F)F)ccc1-2 CHEMBL4568616 IC50 4.0 nM
C=CS(=O)(=O)NC1CCN(c2ccc([C@H](C)Nc3ncc(F)c(N4C(=O)OC[C@@H]4C(C)C)n3)cc2)CC1 CHEMBL5425749 IC50 4.7 nM
CC(C)O[C@H]1CC[C@H](C(=O)N2Cc3cc(F)cnc3Nc3ccc(-c4cnn(C)c4)cc32)OC1 CHEMBL5093219 IC50 4.9 nM
CC(O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)C2CCN(c3ccc(Cl)c(OC(F)(F)F)c3)CC2)ncc1F CHEMBL3950128 IC50 5.0 nM
C[C@H](Nc1nccc(N2C(=O)OC[C@@H]2[C@@H](C)O)n1)c1ccc(-c2ccnc(C(C)(C)C)c2)cn1 CHEMBL3972554 IC50 5.0 nM
Cc1nc(C(C)Nc2nccc(N3C(=O)OCC3[C@H](C)O)n2)sc1-c1ccnc(C(C)(C)C(F)(F)F)c1 CHEMBL3984716 IC50 5.0 nM
CC(Nc1nccc(N2C(=O)OCC2[C@@H](C)O)n1)c1ncc(-c2cccc(C(F)(F)F)c2F)cn1 CHEMBL4112644 IC50 5.0 nM
C[C@H](Nc1ncc(F)c(N2C(=O)OC[C@@H]2CF)n1)c1ncc(-c2ccc(Cl)cc2)o1 CHEMBL3923366 IC50 5.0 nM
N#Cc1ccnc(N2C(=O)CC[C@H]2C(=O)N(c2cc(F)cc(F)c2)[C@@]2(C(=O)NC3CC(F)(F)C3)CCc3ccccc32)c1 CHEMBL4207897 IC50 5.0 nM
CC(Nc1ncc(F)c(N2C(=O)OC[C@@H]2[C@@H](C)O)n1)c1nc(-c2ccc(Cl)c(OC(F)(F)F)c2)no1 CHEMBL4106576 IC50 5.5 nM
N#Cc1ccnc(N2C(=O)OC[C@H]2C(=O)N(c2cccc(F)c2)[C@@]2(C(=O)NC3CC(F)(F)C3)CCc3cccc(Cl)c32)n1 CHEMBL4214223 IC50 5.6 nM
C=CS(=O)(=O)Nc1ccc(Nc2ccc([C@H](C)Nc3ncc(F)c(N4C(=O)OC[C@@H]4C(C)C)n3)cc2)cc1F CHEMBL5420050 IC50 5.9 nM
CC(Nc1ncc(F)c(N2C(=O)OC[C@@H]2[C@@H](C)O)n1)c1cc(-c2ccc(Cl)c(Cl)c2)no1 CHEMBL4107257 IC50 6.0 nM
CC(C)c1ccc(-c2noc(C(C)Nc3ncc(F)c(N4C(=O)OC[C@@H]4[C@@H](C)O)n3)n2)cc1 CHEMBL4114088 IC50 6.0 nM
C[C@H](Nc1ccc(C#N)n(C)c1=O)c1cc2cc(Cl)c(OCc3ccccn3)cc2[nH]c1=O CHEMBL4464313 IC50 6.0 nM
C[C@H](Nc1ccc(C#N)n(C)c1=O)c1cc2cc(Cl)ccc2[nH]c1=O CHEMBL4297610 IC50 6.0 nM
COc1cc(NCc2cc3cc(Cl)c(OCc4ccccn4)cc3[nH]c2=O)ccc1C#N CHEMBL4476454 IC50 6.0 nM
CC(C)COc1ccc([C@H](C)Nc2ncc(F)c(N3C(=O)OC[C@@H]3[C@@H](C)O)n2)c(F)c1 CHEMBL3960560 IC50 7.0 nM
C[C@H](Nc1nccc(N2C(=O)OC[C@@H]2[C@@H](C)F)n1)c1cn(-c2ccc(Cl)cc2)cn1 CHEMBL4107555 IC50 7.0 nM
N#Cc1ccnc(N2C(=O)[C@@H](O)C[C@H]2CC(=O)N(c2cc(F)cc(F)c2)[C@H](C(=O)NC2CC(F)(F)C2)c2ccccc2Cl)n1 CHEMBL4292864 IC50 7.0 nM
FC1(F)CCC(Nc2nc(NC3CCC(F)(F)CC3)nc(-c3cccc(Cl)n3)n2)CC1 CHEMBL4289692 IC50 7.0 nM
COc1cc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N CHEMBL4473772 IC50 7.0 nM
C[C@H](Nc1nc(Cl)cc(N2C(=O)OC[C@@H]2C2CC2)n1)c1cn(-c2ccc(F)cc2)cn1 CHEMBL3342782 IC50 7.27 nM
CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(C(=O)NC3CCCC3)c(F)c2)n1 CHEMBL3682123 IC50 7.5 nM
N#Cc1ccnc(N2C(=O)CC[C@H]2C(=O)N(c2cccc(F)c2)[C@@]2(C(=O)NC3CC(F)(F)C3)CCc3cc(Cl)ccc32)c1 CHEMBL4212544 IC50 7.5 nM
CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(C(=O)NC3CCCCC3)c(F)c2)n1 CHEMBL3682110 IC50 7.86 nM
C[C@H](Nc1nccc(N2C(=O)OC[C@@H]2[C@@H](C)O)n1)c1ccc(-c2ccnc(C(C)(C)C(F)(F)F)c2)cn1 CHEMBL3986728 IC50 8.0 nM
CC(Nc1ncc(F)c(N2C(=O)OC[C@@H]2[C@@H](C)O)n1)c1ncc(-c2ccc(Cl)cc2)o1 CHEMBL4113331 IC50 8.0 nM
N#Cc1ccnc(N2C(=O)CC[C@H]2C(=O)N(c2cncc(F)c2)C(C(=O)NC2CC(F)(F)C2)c2ccccc2Cl)c1 CHEMBL4212374 IC50 8.0 nM
C[C@H](Nc1nccc(N2C(=O)OC[C@@H]2[C@H](C)F)n1)c1ncn2c1CCc1ccc(C(F)(F)F)cc1-2 CHEMBL4474186 IC50 8.0 nM
CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(C(=O)NC3CCCCC3)c(Cl)c2)n1 CHEMBL3682070 IC50 8.12 nM
CC(=O)N1CCN(Cc2ccc([C@H](C)Nc3nccc(N4C(=O)OC[C@@H]4C(C)C)n3)cc2)CC1 CHEMBL3682093 IC50 8.2 nM
CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(C(=O)NC3CCCC3)c(Cl)c2)n1 CHEMBL3682069 IC50 8.35 nM
Cc1cc(N2C(=O)OC[C@@H]2C2CC2)nc(N[C@@H](C)c2cn(-c3ccc(Cl)cc3)cn2)n1 CHEMBL3342781 IC50 8.45 nM
O=C(C1CCN(CC(F)(F)F)CC1)N1Cc2cc(F)cnc2Nc2ccc(N3C[C@@H]4C[C@H]3CO4)cc21 CHEMBL5083820 IC50 8.7 nM
C=CC(=O)N1CCN(C(CC)c2ccc([C@H](C)Nc3nc(N)cc(N4C(=O)OCC4(C)C)n3)cc2)CC1 CHEMBL4586919 IC50 8.89 nM
N#Cc1ccnc(N2C(=O)OC[C@H]2C(=O)N(c2cc(F)cc(F)c2)[C@@]2(C(=O)NC3CC(F)(F)C3)CCc3ccccc32)c1 CHEMBL4210785 IC50 8.9 nM
C[C@H](Nc1nc(Cl)cc(N2C(=O)OC[C@@H]2[C@@H](C)O)n1)c1cc(-c2ccc(Cl)cc2)no1 CHEMBL3923174 IC50 9.0 nM
C[C@H](Nc1ncc(F)c(N2C(=O)OC[C@@H]2[C@@H](C)O)n1)c1ccc(OCC(F)(F)F)c(F)c1 CHEMBL3941791 IC50 9.0 nM
C[C@H](Nc1nccc(N2C(=O)OCC2[C@H](C)F)n1)c1ncc(-c2cccc(C(F)(F)F)c2F)cn1 CHEMBL3891698 IC50 9.0 nM
N#Cc1ccnc(N2C(=O)OC[C@H]2C(=O)N(c2cccc(F)c2)[C@@]2(C(=O)NC3CC(F)(F)C3)CCc3cccc(Cl)c32)c1 CHEMBL4215739 IC50 9.0 nM
COc1nc(N[C@@H](C)c2cc3cc(Cl)c(C4CC4)cc3[nH]c2=O)ncc1C#N CHEMBL4452108 IC50 9.0 nM
C[C@H](Nc1nccc(N2C(=O)OC3(COC3)[C@@H]2c2ccccc2)n1)c1ncn2c1CCc1cc(C(F)(F)F)ccc1-2 CHEMBL4567884 IC50 9.7 nM