CN1CCN(CCn2ccc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccc(-c5cnn(C)c5)cc3)CC4)n2)CC1 CHEMBL3905758 IC50 0.05 nM
COc1cc(N2CCN(C(C)C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3950012 IC50 0.05 nM
Cn1cc(-c2cccc(Cc3c4c(nn3C)CCc3cnc(Nc5ccn(CCCN6CCCC6)n5)nc3-4)c2)cn1 CHEMBL3928243 IC50 0.08 nM
COc1cc(C(=O)NCCCN(C)C)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1Cc1cccc(-c3cnn(C)c3)c1)CC2 CHEMBL3977170 IC50 0.08 nM
COc1cc(N2CCN(C3CCOCC3)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3979064 IC50 0.08 nM
COc1cc(N2CCN(CCO)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3955626 IC50 0.08 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCN5CCN(C)CC5)c4)cc2)CC3)n1 CHEMBL3896205 IC50 0.09 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCN5CCC(N(C)C)CC5)c4)cc2)CC3)n1 CHEMBL3969930 IC50 0.09 nM
CCN1CCN(c2ccc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccc(-c5cnn(C)c5)cc3)CC4)c(OC)c2)CC1 CHEMBL3979509 IC50 0.09 nM
CN(C)C(=O)Cn1cc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)cc2)CC3)cn1 CHEMBL3892425 IC50 0.1 nM
COCCN1CCN(CCn2ccc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccc(-c5cnn(C)c5)cc3)CC4)n2)CC1 CHEMBL3985408 IC50 0.1 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(-c4cnn(CCOC)c4)c2)CC3)n1 CHEMBL3916799 IC50 0.1 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCN5CCNCC5)c4)cc2)CC3)n1 CHEMBL3893323 IC50 0.1 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3952080 IC50 0.1 nM
COc1cc(P(C)(C)=O)ccc1Nc1ncc(Cl)c(Nc2ccccc2C(N)=O)n1 CHEMBL3823268 IC50 0.11 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCNCCOC)c4)cc2)CC3)n1 CHEMBL3961098 IC50 0.11 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCN5CCCC5)c4)cc2)CC3)n1 CHEMBL3986353 IC50 0.11 nM
CC(C)n1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(CCN(C)C)n5)nc3-4)cc2)cn1 CHEMBL3921486 IC50 0.12 nM
COCCn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(CCN(C)C)n5)nc3-4)cc2)cn1 CHEMBL3911964 IC50 0.13 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCN(C)C)c4)cc2)CC3)n1 CHEMBL3965426 IC50 0.13 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCN5CCN(CCO)CC5)c4)cc2)CC3)n1 CHEMBL3907737 IC50 0.13 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCN5CCN(CCOC)CC5)c4)cc2)CC3)n1 CHEMBL3939707 IC50 0.13 nM
COc1cc(C(=O)NCCN(C)C)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3942607 IC50 0.13 nM
COc1cc(C(=O)NCCCN(C)C)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3947924 IC50 0.13 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3972210 IC50 0.14 nM
COCCN1CCC(NC(=O)c2ccc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccc(-c5cnn(C)c5)cc3)CC4)c(OC)c2)CC1 CHEMBL3958897 IC50 0.14 nM
COc1cc(C(=O)NCCN2CCCC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1Cc1cccc(-c3cnn(C)c3)c1)CC2 CHEMBL3951322 IC50 0.14 nM
COc1cc(C(=O)N(C)C2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3946122 IC50 0.14 nM
CCCn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(CCN(C)C)n5)nc3-4)cc2)cn1 CHEMBL3920050 IC50 0.15 nM
CNC(=O)c1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(-c4cnn(C)c4)c2)CC3)c(OC)c1 CHEMBL3976534 IC50 0.15 nM
COc1cc(C(=O)N(C)CCN(C)C)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3952388 IC50 0.15 nM
Cn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(CCCO)n5)nc3-4)cc2)cn1 CHEMBL3967200 IC50 0.16 nM
CN(C)CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(-c4cnn(C)c4)c2)CC3)n1 CHEMBL3891732 IC50 0.16 nM
CCn1cc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)cc2)CC3)cn1 CHEMBL3977626 IC50 0.16 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C5CCNCC5)c4)cc2)CC3)n1 CHEMBL3906800 IC50 0.16 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCO)c4)cc2)CC3)n1 CHEMBL3969767 IC50 0.16 nM
COc1cc(C(=O)N2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3985256 IC50 0.16 nM
COCCN1CCC(NC(=O)c2ccc(Nc3ncc4c(n3)-c3c(nn(C)c3Cc3cccc(-c5cnn(C)c5)c3)CC4)c(OC)c2)CC1 CHEMBL3950693 IC50 0.16 nM
COc1cc(C(=O)NCC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3940776 IC50 0.16 nM
COCCN1CCC(n2cc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccc(-c5cnn(C)c5)cc3)CC4)cn2)CC1 CHEMBL3928015 IC50 0.16 nM
CC(=O)N1CCC(n2cc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccc(-c5cnn(C(C)C)c5)cc3)CC4)cn2)CC1 CHEMBL3982422 IC50 0.17 nM
Cn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(CCN6CCOCC6)n5)nc3-4)cc2)cn1 CHEMBL3962155 IC50 0.17 nM
CN1CCN(CCn2ccc(Nc3ncc4c(n3)-c3c(nn(C)c3Cc3cccc(-c5cnn(C)c5)c3)CC4)n2)CC1 CHEMBL3930224 IC50 0.17 nM
COc1cc(C(=O)N(C)C)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3959576 IC50 0.17 nM
COc1cc(C(=O)NCCN(C)C)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1Cc1cccc(-c3cnn(C)c3)c1)CC2 CHEMBL3985755 IC50 0.17 nM
COc1cc(OCCN2CCCC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3652826 IC50 0.18 nM
CCn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(CCN(C)C)n5)nc3-4)cc2)cn1 CHEMBL3904495 IC50 0.18 nM
CNC(=O)c1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)cc2)CC3)c(OC)c1 CHEMBL3956581 IC50 0.18 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2C CHEMBL3656563 IC50 0.19 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3656576 IC50 0.19 nM
COCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C(C)C)c4)cc2)CC3)n1 CHEMBL3911240 IC50 0.19 nM
COc1cc(C(=O)NC2CN(C)C2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3983444 IC50 0.19 nM
COc1cc2c(cc1Nc1nc(Nc3ccsc3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN(C)C)CCC2(C)C CHEMBL463931 IC50 0.2 nM
CC(=O)N1CCC(n2cc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3sccc3Cl)CC4)cn2)CC1 CHEMBL3656635 IC50 0.2 nM
COCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(Cl)cc2)CC3)n1 CHEMBL3656637 IC50 0.2 nM
CN(C)CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCO)c4)cc2)CC3)n1 CHEMBL3912872 IC50 0.2 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1Cc1cccc(-c3cnn(C)c3)c1)CC2 CHEMBL3957098 IC50 0.2 nM
CC(C)n1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5cnn(CCN(C)C)c5)nc3-4)cc2)cn1 CHEMBL3893469 IC50 0.21 nM
Cn1cc(-c2cccc(Cc3c4c(nn3C)CCc3cnc(Nc5ccn(CCN6CCOCC6)n5)nc3-4)c2)cn1 CHEMBL3939222 IC50 0.21 nM
CC(=O)N1CCC(n2cc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccc(-c5cnn(C)c5)cc3)CC4)cn2)CC1 CHEMBL3962418 IC50 0.21 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CC(=O)N(C)C)c4)cc2)CC3)n1 CHEMBL3920449 IC50 0.21 nM
COc1cc(C(=O)NCCN2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3939119 IC50 0.21 nM
CCS(=O)(=O)CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(-c4cnn(C)c4)c2)CC3)n1 CHEMBL3943015 IC50 0.22 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCOC)c4)cc2)CC3)n1 CHEMBL3943667 IC50 0.22 nM
COc1cc(C(=O)N2CCOCC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3924709 IC50 0.22 nM
COCCN(C)C(=O)c1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)cc2)CC3)c(OC)c1 CHEMBL3969265 IC50 0.22 nM
Cn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(CCO)n5)nc3-4)cc2)cn1 CHEMBL3981473 IC50 0.23 nM
Cn1cc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(-c4cnn(C)c4)c2)CC3)cn1 CHEMBL3905880 IC50 0.23 nM
Cn1cc(-c2cccc(Cc3c4c(nn3C)CCc3cnc(Nc5ccn(CCCn6ccnc6)n5)nc3-4)c2)cn1 CHEMBL3926795 IC50 0.23 nM
COc1cc(C(=O)N[C@@H]2CCN(C)C[C@H]2OC)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL4112878 IC50 0.23 nM
Cn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5cnn(C6CCN(S(C)(=O)=O)CC6)c5)nc3-4)cc2)cn1 CHEMBL3979595 IC50 0.23 nM
COCCN1CCN(CCn2ccc(Nc3ncc4c(n3)-c3c(nn(C)c3Cc3cccc(-c5cnn(C)c5)c3)CC4)n2)CC1 CHEMBL3914672 IC50 0.24 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(-c4cnn(C)c4)c2)CC3)n1 CHEMBL3953426 IC50 0.24 nM
CN(C)[C@H]1CCN(C(=O)Cn2ccc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccc(-c5cnn(C)c5)cc3)CC4)n2)C1 CHEMBL3962491 IC50 0.24 nM
COCCCn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(CCN(C)C)n5)nc3-4)cc2)cn1 CHEMBL3979113 IC50 0.25 nM
COCCn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(CCOC)n5)nc3-4)cc2)cn1 CHEMBL3901431 IC50 0.25 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCN(C)CCOC)c4)cc2)CC3)n1 CHEMBL3902316 IC50 0.25 nM
CCOc1cc(N2CCN(C(C)C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1Cc1ccccc1)CC2 CHEMBL3661006 IC50 0.26 nM
Cn1cc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)cc2)CC3)cn1 CHEMBL3917016 IC50 0.26 nM
CN(C)CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)cc2)CC3)n1 CHEMBL3965342 IC50 0.26 nM
COc1cc(C(=O)NC(C)C)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3900113 IC50 0.26 nM
COCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCN5CCC(C#N)CC5)c4)cc2)CC3)n1 CHEMBL3915501 IC50 0.26 nM
COc1cc(C(=O)N[C@H]2CC[C@H](N3CCOCC3)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660916 IC50 0.27 nM
Cc1cc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)cc2)CC3)nn1C CHEMBL3913210 IC50 0.27 nM
CN(C)CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CC(=O)N(C)C)c4)cc2)CC3)n1 CHEMBL3937320 IC50 0.27 nM
Cn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5cnn(Cc6ccncc6)c5)nc3-4)cc2)cn1 CHEMBL3937351 IC50 0.28 nM
COCCn1cc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C(C)C)c4)cc2)CC3)cn1 CHEMBL3938222 IC50 0.28 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCCOC)c4)cc2)CC3)n1 CHEMBL3950079 IC50 0.28 nM
CCCN1CCC(c2ccc(Nc3nc(Nc4cc(F)ccc4C(N)=O)c4cc[nH]c4n3)c(OC)c2)CC1 CHEMBL476259 IC50 0.3 nM
COc1cc2c(cc1Nc1nc(Nc3ccsc3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN(C)C)CC2 CHEMBL514873 IC50 0.3 nM
COc1cc2c(cc1Nc1nc(Nc3ccoc3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN(C)C)CCC2 CHEMBL458414 IC50 0.3 nM
COc1ccc(-c2c3c(nn2C)CCc2cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc2-3)c(Cl)c1 CHEMBL3656608 IC50 0.3 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2sccc2C)CC3)n1 CHEMBL3656638 IC50 0.3 nM
Cn1cc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2sccc2Cl)CC3)cn1 CHEMBL3639555 IC50 0.3 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1sccc1Cl)CC2 CHEMBL3660996 IC50 0.3 nM
CN(C)CCCNC(=O)Cn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)cc2)CC3)n1 CHEMBL3902464 IC50 0.3 nM
CCOc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1Cc1ccccc1)CC2 CHEMBL3661005 IC50 0.31 nM
CC(C)Cn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(CCN(C)C)n5)nc3-4)cc2)cn1 CHEMBL3963245 IC50 0.31 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)cc2Cl)CC3)n1 CHEMBL3941008 IC50 0.31 nM
CCCn1cc(-c2cccc(Cc3c4c(nn3C)CCc3cnc(Nc5ccn(CC)n5)nc3-4)c2)cn1 CHEMBL3900377 IC50 0.31 nM
COCCn1cc(-c2cccc(Cc3c4c(nn3C)CCc3cnc(Nc5ccn(C)n5)nc3-4)c2)cn1 CHEMBL3922742 IC50 0.31 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCN5CCOCC5)c4)cc2)CC3)n1 CHEMBL3946047 IC50 0.31 nM
CC(C)n1cc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)nc2)CC3)cn1 CHEMBL3913675 IC50 0.31 nM
Cn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(-c4cnn(C5CCOCC5)c4)c2)CC3)n1 CHEMBL3966970 IC50 0.32 nM
Cn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(CC(=O)N6CCCC6)n5)nc3-4)cc2)cn1 CHEMBL3915025 IC50 0.33 nM
CN(C)S(=O)(=O)N1CCC(n2cc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccc(-c5cnn(C)c5)cc3)CC4)cn2)CC1 CHEMBL3891063 IC50 0.34 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 IC50 0.35 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C(C)C)c4)cc2)CC3)n1 CHEMBL3975858 IC50 0.35 nM
CN(C)CCn1cc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)cc2)CC3)cn1 CHEMBL3922256 IC50 0.35 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(-c4cnn(CC(C)C)c4)c2)CC3)n1 CHEMBL3891342 IC50 0.35 nM
COCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCN5CCO[C@@H](C)C5)c4)cc2)CC3)n1 CHEMBL3948924 IC50 0.35 nM
Cn1cc(-c2cccc(Cc3c4c(nn3C)CCc3cnc(Nc5ccn(C)n5)nc3-4)c2)cn1 CHEMBL3914262 IC50 0.36 nM
COCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(-c4cnn(C)c4)c2)CC3)n1 CHEMBL3936471 IC50 0.36 nM
COCCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(-c4cnn(C)c4)c2)CC3)n1 CHEMBL3912328 IC50 0.37 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(-c4cn[nH]c4)c2)CC3)n1 CHEMBL3931181 IC50 0.37 nM
COCCNC(=O)c1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(-c4cnn(C)c4)c2)CC3)c(OC)c1 CHEMBL3968669 IC50 0.37 nM
CCNC(=O)c1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)cc2)CC3)c(OC)c1 CHEMBL3940235 IC50 0.37 nM
Cn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5cnn(CCN6CCOCC6)c5)nc3-4)cc2)cn1 CHEMBL3907023 IC50 0.38 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)cc2)CC3)n1 CHEMBL3933022 IC50 0.38 nM
COCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCO)c4)cc2)CC3)n1 CHEMBL3911995 IC50 0.38 nM
CN(C)CCNC(=O)Cn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)cc2)CC3)n1 CHEMBL3951247 IC50 0.38 nM
COc1cc(C(=O)NCCN2CCOCC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3961082 IC50 0.38 nM
COCCCNC(=O)c1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)cc2)CC3)c(OC)c1 CHEMBL3930123 IC50 0.38 nM
CC(=O)N1CCC(n2cc(Nc3ncc4c(n3)-c3c(nn(C)c3Cc3cccc(-c5cnn(C)c5)c3)CC4)cn2)CC1 CHEMBL3984078 IC50 0.39 nM
CCCn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(CC(=O)N(C)C)n5)nc3-4)cc2)cn1 CHEMBL3947851 IC50 0.39 nM
CNC(=O)Cn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)cc2)CC3)n1 CHEMBL3923532 IC50 0.39 nM
Cn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(CC(=O)N6CCOCC6)n5)nc3-4)cc2)cn1 CHEMBL3896951 IC50 0.39 nM
COc1cc(C(=O)NC[C@@H]2CCCO2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3978615 IC50 0.39 nM
CCCN1CCCC(c2ccc(Nc3nc(Nc4cc(F)ccc4C(N)=O)c4cc[nH]c4n3)c(OC)c2)C1 CHEMBL477069 IC50 0.4 nM
COc1cc(P(C)(C)=O)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(C)(=O)=O)n1 CHEMBL3823256 IC50 0.4 nM
COc1ccc(-c2c3c(nn2C)CCc2cnc(Nc4ccc(C(=O)NC5CCN(C)CC5)cc4OC)nc2-3)c(Cl)c1 CHEMBL3656609 IC50 0.4 nM
Cn1nc2c(c1-c1sccc1Cl)-c1nc(Nc3ccccc3)ncc1CC2 CHEMBL3656639 IC50 0.4 nM
CN(C)C1CCN(CCn2ccc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccccc3)CC4)n2)CC1 CHEMBL3656640 IC50 0.4 nM
COc1ccc(-c2c3c(nn2C)CCc2cnc(Nc4cnn(C5CCN(C(C)=O)CC5)c4)nc2-3)cc1 CHEMBL3656641 IC50 0.4 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1Cc1ccccc1Cl)CC2 CHEMBL3660997 IC50 0.4 nM
CCn1cc(-c2ccc(-c3c4c(nn3C)CC(C)c3cnc(Nc5ccn(C)n5)nc3-4)cc2)cn1 CHEMBL3961022 IC50 0.41 nM
CC(C)n1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5cnn(CCN6CCOCC6)c5)nc3-4)cc2)cn1 CHEMBL3915991 IC50 0.42 nM
CCOc1cc(N2CCN(C3CCOCC3)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1Cc1ccccc1)CC2 CHEMBL3661004 IC50 0.43 nM
COCCn1cc(-c2ccc(-c3c4c(nn3C)CC(C)c3cnc(Nc5ccn(C)n5)nc3-4)cc2)cn1 CHEMBL3951174 IC50 0.44 nM
CN(C)CCn1cc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(-c4cnn(C)c4)c2)CC3)cn1 CHEMBL3905954 IC50 0.46 nM
CC1Cc2nn(C)c(-c3ccc(-c4cnn(C)c4)cc3)c2-c2nc(Nc3ccn(C)n3)ncc21 CHEMBL3933556 IC50 0.46 nM
COc1cc(P(C)(C)=O)ccc1Nc1ncc(Cl)c(Nc2ccccc2C(C)=O)n1 CHEMBL3824326 IC50 0.47 nM
COCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCN5CCOCC5)c4)cc2)CC3)n1 CHEMBL3891058 IC50 0.48 nM
Cn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(-c4cnn(CCN5CCOCC5)c4)c2)CC3)n1 CHEMBL3895693 IC50 0.48 nM
CCn1cc(-c2cccc(Cc3c4c(nn3C)CCc3cnc(Nc5ccn(CC)n5)nc3-4)c2)cn1 CHEMBL3928318 IC50 0.49 nM
COc1cc(N2CCN(C(C)C)CC2)ccc1Nc1nc(Nc2cc(F)c(F)cc2C(N)=O)c2cc[nH]c2n1 CHEMBL475073 IC50 0.5 nM
COc1cc2c(cc1Nc1nc(N3CCc4ccccc43)c3cc[nH]c3n1)N(C(=O)CN(C)C)CCC2 CHEMBL457105 IC50 0.5 nM
COc1cc2c(cc1Nc1nc(Nc3cccnc3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN(C)C)CCC2 CHEMBL458864 IC50 0.5 nM
COc1cc(C)c(NC(=O)CN(C)C)cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 CHEMBL511765 IC50 0.5 nM
COc1ccc(-c2c3c(nn2C)CCc2cnc(Nc4ccc(OCCN5CCCC5)cc4OC)nc2-3)c(Cl)c1 CHEMBL3656606 IC50 0.5 nM
CN(C)CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2sccc2Cl)CC3)n1 CHEMBL3656642 IC50 0.5 nM
CC(=O)N1CCC(n2cc(Nc3ncc4c(n3)-c3c(nn(C)c3Cc3ccccc3C)CC4)cn2)CC1 CHEMBL3656643 IC50 0.5 nM
COc1cc(N2CCN(C(C)C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1Cc1cccc(Cl)c1)CC2 CHEMBL3661009 IC50 0.5 nM
CN(C)C(=O)Cn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)cc2)CC3)n1 CHEMBL3956517 IC50 0.51 nM
COCCN(C)C(=O)Cn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)cc2)CC3)n1 CHEMBL3973461 IC50 0.51 nM
COc1cc(C(=O)NC2CCN(CCO)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660915 IC50 0.54 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(Cc5ccccc5)c4)cc2)CC3)n1 CHEMBL3959347 IC50 0.55 nM
COCCNC(=O)Cn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)cc2)CC3)n1 CHEMBL3939571 IC50 0.56 nM
CCOc1cc(C(=O)NC2CN(C)C2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1Cc1ccccc1)CC2 CHEMBL3660954 IC50 0.57 nM
CN(C)CCNC(=O)Cn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(-c4cnn(C)c4)c2)CC3)n1 CHEMBL3895851 IC50 0.57 nM
CCCn1cc(-c2cccc(Cc3c4c(nn3C)CCc3cnc(Nc5ccn(C)n5)nc3-4)c2)cn1 CHEMBL3980340 IC50 0.57 nM
CCn1cc(-c2cccc(Cc3c4c(nn3C)CCc3cnc(Nc5ccn(C)n5)nc3-4)c2)cn1 CHEMBL3910215 IC50 0.59 nM
CCCN1CCC=C(c2ccc(Nc3nc(Nc4ccccc4C(N)=O)c4cc[nH]c4n3)c(OC)c2)C1 CHEMBL514868 IC50 0.6 nM
CCOc1cc(-c2ccccc2)nc2cc(-c3nc([C@H]4C[C@@](C)(O)C4)n4ccnc(N)c34)ccc12 CHEMBL3037909 IC50 0.6 nM
Cn1nc2c(c1-c1ccccc1)-c1nc(Nc3ccn(CCN4CCN(CCO)CC4)n3)ncc1CC2 CHEMBL3656632 IC50 0.6 nM
COCCN1CCN(CCn2ccc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccccc3)CC4)n2)CC1 CHEMBL3656633 IC50 0.6 nM
CC(=O)N1CCC(n2cc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3sccc3C)CC4)cn2)CC1 CHEMBL3656644 IC50 0.6 nM
COCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2sccc2Cl)CC3)n1 CHEMBL3656645 IC50 0.6 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2sccc2Cl)CC3)n1 CHEMBL3656646 IC50 0.6 nM
Cn1nc2c(c1-c1ccccc1)-c1nc(Nc3ccn(CCN4CCNCC4)n3)ncc1CC2 CHEMBL3656647 IC50 0.6 nM
CCn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(CC(=O)N(C)C)n5)nc3-4)cc2)cn1 CHEMBL3915559 IC50 0.61 nM
COc1cc(C(=O)NC2CCOCC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3970326 IC50 0.61 nM
CCOc1cc(N2CCNCC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1Cc1ccccc1)CC2 CHEMBL3661002 IC50 0.63 nM
CCCNC(=O)c1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)cc2)CC3)c(OC)c1 CHEMBL3915717 IC50 0.66 nM
CC(C)n1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5cnn(CC(=O)N(C)C)c5)nc3-4)cc2)cn1 CHEMBL3958673 IC50 0.68 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1[C@@H](C)c1ccccc1)CC2 CHEMBL3652847 IC50 0.69 nM
COc1cc(N2CCN(C(C)C)CC2)ccc1Nc1nc(Nc2cc(F)ccc2C(N)=O)c2cc[nH]c2n1 CHEMBL459069 IC50 0.7 nM
COc1cc2c(cc1Nc1nc(Nc3cccnc3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN(C)C)CC2 CHEMBL514258 IC50 0.7 nM
COc1cc(-c2ccccc2)nc2cc(-c3nc([C@H]4C[C@@](C)(O)C4)n4ccnc(N)c34)ccc12 CHEMBL3037908 IC50 0.7 nM
COCCn1cc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2sccc2Cl)CC3)cn1 CHEMBL3656648 IC50 0.7 nM
CN(C)C(=O)Cn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCN5CCOCC5)c4)cc2)CC3)n1 CHEMBL3972128 IC50 0.74 nM
COc1cc(C(=O)NCCCN(C)C)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660913 IC50 0.75 nM
CC1Cc2nn(C)c(-c3ccc(-c4cnn(C(C)C)c4)cc3)c2-c2nc(Nc3ccn(C)n3)ncc21 CHEMBL3926973 IC50 0.75 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(C)(=O)=O)n1 CHEMBL3822475 IC50 0.76 nM
COCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)cc2)CC3)n1 CHEMBL3928688 IC50 0.76 nM
CCn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(CC)n5)nc3-4)cc2)cn1 CHEMBL3905064 IC50 0.78 nM
Cn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(C)n5)nc3-4)cc2)cn1 CHEMBL3925828 IC50 0.79 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(-c4cnn(Cc5ccccc5)c4)c2)CC3)n1 CHEMBL3922909 IC50 0.79 nM
CCCN1CCC=C(c2ccc(Nc3nc(Nc4cc(F)ccc4C(N)=O)c4cc[nH]c4n3)c(OC)c2)C1 CHEMBL476044 IC50 0.8 nM
COc1cc(N2CCN(C(C)C)CC2)ccc1Nc1nc(Nc2ccc(F)cc2C(N)=O)c2cc[nH]c2n1 CHEMBL458865 IC50 0.8 nM
COc1cc(N2CCN(C(C)C)CC2)ccc1Nc1nc(Nc2cc(F)cc(F)c2C(N)=O)c2cc[nH]c2n1 CHEMBL464971 IC50 0.8 nM
COc1cc2c(cc1Nc1nc(Nc3ccoc3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN(C)C)CC2 CHEMBL515519 IC50 0.8 nM
COc1cc2c(cc1Nc1nc(N3CCc4ccccc43)c3cc[nH]c3n1)N(C(=O)CN(C)C)CC2 CHEMBL458415 IC50 0.8 nM
COc1cc2c(cc1Nc1nc(Nc3cccc4c3C(=O)NC4)c3cc[nH]c3n1)N(C(=O)CN(C)C)CC2 CHEMBL517163 IC50 0.8 nM
COc1cc(OCCN2CCCC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2C CHEMBL3656562 IC50 0.8 nM
CN(C)C(=O)CCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(-c4cnn(C)c4)c2)CC3)n1 CHEMBL3972618 IC50 0.8 nM
CCCn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(CCOC)n5)nc3-4)cc2)cn1 CHEMBL3983748 IC50 0.82 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3656578 IC50 0.87 nM
COc1cc(C(=O)NC2CN(C)C2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660980 IC50 0.87 nM
Cc1cc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(-c4cnn(C)c4)c2)CC3)nn1C CHEMBL3930438 IC50 0.87 nM
CC(C)n1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(C)n5)nc3-4)cc2)cn1 CHEMBL3942360 IC50 0.88 nM
Cn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(-c4cnn(CCO)c4)c2)CC3)n1 CHEMBL3904641 IC50 0.9 nM
Cn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(CC(C)(C)O)n5)nc3-4)cc2)cn1 CHEMBL3906140 IC50 0.91 nM
CN(C)C(=O)Cn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCO)c4)cc2)CC3)n1 CHEMBL3939058 IC50 0.91 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1C)CC2 CHEMBL3656544 IC50 0.92 nM
C[C@@]1(C(=O)Nc2ccc(F)nc2)CCCN1c1nc(Nc2cc(C3CC3)n[nH]2)c2cccn2n1 CHEMBL575448 KD 0.9615 nM
COc1cc(N2CCN(C(C)C)CC2)ccc1Nc1nc(Nc2ccccc2C(N)=O)c2cc[nH]c2n1 CHEMBL514828 IC50 1.0 nM
CN(C)CCOc1cccc(Nc2nccc(-c3c(-c4cccc(C(=O)Nc5c(F)cccc5F)c4)nc4ccccn34)n2)c1 CHEMBL448668 IC50 1.0 nM
CN(C)C[C@H](O)COc1cccc(Nc2nccc(-c3c(-c4cccc(C(=O)Nc5c(F)cccc5F)c4)nc4ccccn34)n2)c1 CHEMBL500198 IC50 1.0 nM
COc1cc2c(cc1Nc1nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN(C)C)CC2 CHEMBL461876 IC50 1.0 nM
COc1ccc(NC(=O)CN(C)C)cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 CHEMBL468619 IC50 1.0 nM
COc1cc2c(cc1Nc1nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN1CCCC1)CC2 CHEMBL517947 IC50 1.0 nM
COc1cc2c(cc1Nc1nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN1CCC1)CC2 CHEMBL465168 IC50 1.0 nM
COc1cc2c(cc1Nc1nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN(C)C)CCC2 CHEMBL516870 IC50 1.0 nM
COc1cc2c(cc1Nc1nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN1CCCCC1)CCC2 CHEMBL467136 IC50 1.0 nM
O=C(Nc1ccc(F)nc1)[C@@H]1CCCN1c1nc(Nc2cc(C3CC3)[nH]n2)c2cccn2n1 CHEMBL1222709 IC50 1.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(CN)Cc4ccccc4)c3)cc12 CHEMBL2000271 pKi 1.0 nM
O=C(Nc1cccnc1)[C@@H]1C[C@H](O)CN1c1nc(Nc2cc(C3CC3)n[nH]2)c2cccn2n1 CHEMBL3639546 IC50 1.0 nM
CO[C@@H]1C[C@@H](C(=O)Nc2ccc(F)nc2)N(c2nc(Nc3cc(C4CC4)n[nH]3)c3cccn3n2)C1 CHEMBL3655750 IC50 1.0 nM
CO[C@H]1C[C@@H](C(=O)Nc2ccc(F)nc2)N(c2nc(Nc3cc(C4CC4)n[nH]3)c3cccn3n2)C1 CHEMBL3655752 IC50 1.0 nM
CC1(c2cc(Nc3nc(N4C[C@@H](O)C[C@H]4C(=O)Nc4ncns4)nn4cccc34)[nH]n2)CC1 CHEMBL3655756 IC50 1.0 nM
CC1Cc2nn(C)c(-c3ccccc3Cl)c2-c2nc(Nc3ccn(C)n3)ncc21 CHEMBL3652841 IC50 1.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1Cc1ccccc1)CC2 CHEMBL3652849 IC50 1.0 nM
COc1ccccc1Cc1c2c(nn1C)CCc1cnc(Nc3ccc(OCCN4CCCC4)cc3OC)nc1-2 CHEMBL3652862 IC50 1.0 nM
COc1ccccc1Cc1c2c(nn1C)CCc1cnc(Nc3ccc(N4CCN(C)CC4)cc3OC)nc1-2 CHEMBL3652864 IC50 1.0 nM
COc1cc(OCCN2CCCC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1C)CC2 CHEMBL3656542 IC50 1.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(C)cc1C)CC2 CHEMBL3656559 IC50 1.0 nM
COc1cc(OCCN2CCCC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1cccc(C)c1Cl)CC2 CHEMBL3656612 IC50 1.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1cccc(C)c1Cl)CC2 CHEMBL3656614 IC50 1.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(F)cc1Cl)CC2 CHEMBL3656619 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2C CHEMBL3656623 IC50 1.0 nM
COCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccccc2)C[C@H]3C)n1 CHEMBL3656634 IC50 1.0 nM
Cc1ccsc1-c1c2c(nn1C)CCc1cnc(Nc3cnn(C)c3)nc1-2 CHEMBL3656649 IC50 1.0 nM
CN1CCN(CCn2ccc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccccc3)CC4)n2)CC1 CHEMBL3656650 IC50 1.0 nM
CC(=O)N1CCC(n2cc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccccc3)CC4C)cn2)CC1 CHEMBL3656651 IC50 1.0 nM
COCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2ccccc2C)CC3)n1 CHEMBL3656652 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C3CCOCC3)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660914 IC50 1.0 nM
COc1cc(C(=O)NC2CC(N3CCCC3)C2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660919 IC50 1.0 nM
COc1cc(C(=O)NCC(C)(C)CN(C)C)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660922 IC50 1.0 nM
COc1cc(C(=O)N[C@H]2CCCN(C3CCOCC3)C2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660923 IC50 1.0 nM
COc1cc(C(=O)NCC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660925 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C(C)(C)C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660926 IC50 1.0 nM
COc1cc(C(=O)NC2CC(N3CCN(C)CC3)C2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660932 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C(C)(C)C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2C CHEMBL3660934 IC50 1.0 nM
CCN1CCC(NC(=O)c2ccc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccccc3Cl)CC4C)c(OC)c2)CC1 CHEMBL3660936 IC50 1.0 nM
COCCN1CCC(NC(=O)c2ccc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccccc3Cl)CC4C)c(OC)c2)CC1 CHEMBL3660937 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(CCO)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2C CHEMBL3660939 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C3CCOCC3)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2C CHEMBL3660941 IC50 1.0 nM
COc1cc(C(=O)NC2CN(C)C2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2C CHEMBL3660942 IC50 1.0 nM
COc1cc(C(=O)NCCN(C)C)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660977 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1sccc1C)CC2 CHEMBL3660998 IC50 1.0 nM
COc1cc(N2CCN(C3CCOCC3)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1Cc1cccc(Cl)c1)CC2 CHEMBL3661007 IC50 1.0 nM
COc1cc(N2CCN(C3CCN(C(C)=O)CC3)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1Cc1cccc(Cl)c1)CC2 CHEMBL3661008 IC50 1.0 nM
CCN1CCN(c2ccc(Nc3ncc4c(n3)-c3c(nn(C)c3Cc3cccc(Cl)c3)CC4)c(OC)c2)CC1 CHEMBL3661010 IC50 1.0 nM
CC1Cc2nn(C)c(Cc3ccccc3Cl)c2-c2nc(Nc3cnn(C4CCN(C5CCOCC5)CC4)c3)ncc21 CHEMBL3661011 IC50 1.0 nM
CC(=O)N1CCC(N2CCC(n3cc(Nc4ncc5c(n4)-c4c(nn(C)c4Cc4ccccc4Cl)CC5C)cn3)CC2)CC1 CHEMBL3661012 IC50 1.0 nM
CC1Cc2nn(C)c(Cc3ccccc3Cl)c2-c2nc(Nc3cnn(C4CCN(CCO)CC4)c3)ncc21 CHEMBL3661013 IC50 1.0 nM
CN(C)C(=O)Cn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(-c4cnn(C)c4)c2)CC3)n1 CHEMBL3923257 IC50 1.0 nM
Cn1cc(-c2cccc(Cc3c4c(nn3C)CCc3cnc(Nc5ccn(CC(=O)N6CCOCC6)n5)nc3-4)c2)cn1 CHEMBL3980637 IC50 1.0 nM
CCCn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(CC)n5)nc3-4)cc2)cn1 CHEMBL3905672 IC50 1.0 nM
CCn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(CCOC)n5)nc3-4)cc2)cn1 CHEMBL3913925 IC50 1.0 nM
COCCn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(CC(=O)N(C)C)n5)nc3-4)cc2)cn1 CHEMBL3977109 IC50 1.0 nM
COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3952095 IC50 1.0 nM
CCn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccc(C(=O)O)cc5OC)nc3-4)cc2)cn1 CHEMBL3900758 IC50 1.0 nM
COCCn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccc(C(=O)O)cc5OC)nc3-4)cc2)cn1 CHEMBL3903471 IC50 1.0 nM
COCCN1CCN(CCn2ccc(Nc3ncc4c(n3)C(C)Cc3nn(C)c(-c5ccccc5)c3-4)n2)CC1 CHEMBL5182271 IC50 1.0 nM
COc1cc(N2CCN(C(C)C)CC2)ccc1Nc1nc(Nc2ccc(F)c(F)c2C(N)=O)c2cc[nH]c2n1 CHEMBL463932 IC50 1.3 nM
CCCN1CCC(c2ccc(Nc3nc(Nc4ccsc4C(N)=O)c4cc[nH]c4n3)c(OC)c2)CC1 CHEMBL515846 IC50 1.3 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2C(C)=O)n1 CHEMBL3824301 IC50 1.33 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2C(N)=O)n1 CHEMBL3824246 IC50 1.4 nM
CCCN1CCC=C(c2ccc(Nc3nc(Nc4ccccc4C(N)=O)c4cc[nH]c4n3)cc2)C1 CHEMBL476451 IC50 1.6 nM
CCCN1CCC=C(c2ccc(Nc3nc(Nc4ccccc4C(N)=O)c4cc[nH]c4n3)c(F)c2)C1 CHEMBL1964272 IC50 1.6 nM
CCCN1CCN(c2ccc(Nc3nc(Nc4cc(F)ccc4C(N)=O)c4cc[nH]c4n3)c(OC)c2)CC1 CHEMBL476059 IC50 1.6 nM
COc1cc(N2CCOCC2)ccc1Nc1nc(Nc2cc(F)ccc2C(N)=O)c2cc[nH]c2n1 CHEMBL477950 IC50 1.6 nM
COc1cc(N2CCN(C(C)C)CC2)c(Cl)cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 CHEMBL514615 IC50 1.6 nM
CCc1cc(Nc2nccc(-c3c(-c4ccc(OC)c(C(=O)Nc5c(F)cccc5F)c4)nc4ccccn34)n2)c(OC)cc1N1CCC(N2CCN(S(C)(=O)=O)CC2)CC1 CHEMBL466397 Ki(app) 1.6 nM
COc1cc(N2CCN(C(C)C)CC2)ccc1Nc1nc(Nc2ccsc2C(N)=O)c2cc[nH]c2n1 CHEMBL514718 IC50 1.6 nM
COc1cc(P(C)(C)=O)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL3824304 IC50 1.9 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)N(C)C)n1 CHEMBL3822672 IC50 1.93 nM
COc1cc(N2CCN(C(C)C)CC2)ccc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 CHEMBL507625 IC50 2.0 nM
COc1cc(N2CCN(C(C)C)CC2)c(F)cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 CHEMBL475883 IC50 2.0 nM
COc1cc(N2CCN(C(C)C)CC2)c(C)cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 CHEMBL475884 IC50 2.0 nM
CN(C)CCCc1ccc(Nc2nccc(-c3c(-c4cccc(C(=O)Nc5c(F)cccc5F)c4)nc4ccccn34)n2)cc1 CHEMBL447668 IC50 2.0 nM
O=C(Nc1c(F)cccc1F)c1cccc(-c2nc3ccccn3c2-c2ccnc(Nc3ccc(N4CCC(N5CCCCC5)CC4)cc3)n2)c1 CHEMBL453438 IC50 2.0 nM
COc1cc(N2CCC(N3CCCCC3)CC2)ccc1Nc1nccc(-c2c(-c3cccc(C(=O)Nc4c(F)cccc4F)c3)nc3ccccn23)n1 CHEMBL506862 IC50 2.0 nM
COc1cc(N2CCC(N3CCOCC3)CC2)ccc1Nc1nccc(-c2c(-c3cccc(C(=O)Nc4c(F)cccc4F)c3)nc3ccccn23)n1 CHEMBL502652 IC50 2.0 nM
COc1cc(N2CCC(N3CCCC3)CC2)ccc1Nc1nccc(-c2c(-c3cccc(C(=O)Nc4c(F)cccc4F)c3)nc3ccccn23)n1 CHEMBL502198 IC50 2.0 nM
COc1cc(N2CCC(N3CC[C@@H](F)C3)CC2)ccc1Nc1nccc(-c2c(-c3cccc(C(=O)Nc4c(F)cccc4F)c3)nc3ccccn23)n1 CHEMBL508627 IC50 2.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1nccc(-c2c(-c3cccc(C(=O)Nc4c(F)cccc4F)c3)nc3ccccn23)n1 CHEMBL449110 IC50 2.0 nM
CNC(=O)c1cscc1Nc1nc(Nc2cc3c(cc2OC)CCN3C(=O)CN(C)C)nc2[nH]ccc12 CHEMBL457548 IC50 2.0 nM
CNCC(=O)N1CCc2cc(OC)c(Nc3nc(Nc4cccc(F)c4C(N)=O)c4cc[nH]c4n3)cc21 CHEMBL461018 IC50 2.0 nM
CCN(CC)CC(=O)N1CCc2cc(OC)c(Nc3nc(Nc4cccc(F)c4C(N)=O)c4cc[nH]c4n3)cc21 CHEMBL464757 IC50 2.0 nM
CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3c(cc2OC)CCN3C(=O)CN(C)C)nc2[nH]ccc12 CHEMBL464552 IC50 2.0 nM
O=C(Nc1nccs1)[C@@H]1CCCN1c1nc(Nc2cc(C3CC3)[nH]n2)c2cccn2n1 CHEMBL584355 IC50 2.0 nM
Nc1nccn2c1c(-c1ccc3ccc(-c4ccccc4)nc3c1F)nc2[C@H]1CC[C@H](C(=O)Nc2nccs2)CC1 CHEMBL1667943 IC50 2.0 nM
COc1cc(N2CC3CN(CCO)CC(C2)O3)ccc1Nc1ncc(Cl)c(-c2cnc3ccccn23)n1 CHEMBL1809059 IC50 2.0 nM
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(-c3cnn4ccccc34)n2)c(OC)cc1N1CCN(C)CC1 CHEMBL2426277 IC50 2.0 nM
C[C@]1(O)C[C@@H](c2nc(-c3ccc4ccc(-c5ccccc5)nc4c3)c3c(N)nccn32)C1 CHEMBL1091644 IC50 2.0 nM
C[C@@]1(C(=O)Nc2cnccn2)CCCN1c1nc(Nc2cc(C3CC3)[nH]n2)c2cccn2n1 CHEMBL575447 IC50 2.0 nM
O=C(Nc1cnccn1)[C@@H]1C[C@H](O)CN1c1nc(Nc2cc(C3CC3)n[nH]2)c2cccn2n1 CHEMBL3655747 IC50 2.0 nM
CO[C@H]1C[C@@H](C(=O)Nc2ncns2)N(c2nc(Nc3cc(C4CC4)n[nH]3)c3cccn3n2)C1 CHEMBL3655753 IC50 2.0 nM
CC1(c2cc(Nc3nc(N4C[C@@H](O)C[C@H]4C(=O)Nc4cnccn4)nn4cccc34)[nH]n2)CC1 CHEMBL3655754 IC50 2.0 nM
O=C(Nc1ncns1)[C@@H]1C[C@@H](F)CN1c1nc(Nc2cc(C3CC3)n[nH]2)c2cccn2n1 CHEMBL3655757 IC50 2.0 nM
Cc1nnn([C@H]2C[C@@H](C(=O)Nc3ccc(F)nc3)N(c3nc(Nc4cc(C5CC5)n[nH]4)c4cccn4n3)C2)n1 CHEMBL3655759 IC50 2.0 nM
Cn1nc2c(c1-c1ccccc1Cl)-c1nc(Nc3ccccc3)ncc1CC2 CHEMBL3652820 IC50 2.0 nM
Cn1nccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3652822 IC50 2.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1)CC2 CHEMBL3652825 IC50 2.0 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccccc2Cl)CC3)n1 CHEMBL3652829 IC50 2.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1Cc1ccccc1)CC2 CHEMBL3652848 IC50 2.0 nM
COc1ccccc1Cc1c2c(nn1C)CCc1cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc1-2 CHEMBL3652865 IC50 2.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1C)CC2 CHEMBL3656545 IC50 2.0 nM
COc1cc(OCCN2CCCC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(C)cc1C)CC2 CHEMBL3656557 IC50 2.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(C)cc1C)CC2 CHEMBL3656560 IC50 2.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1cccc(C)c1Cl)CC2 CHEMBL3656616 IC50 2.0 nM
COc1cc(OCCN2CCCC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(F)cc1Cl)CC2 CHEMBL3656617 IC50 2.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(F)cc1Cl)CC2 CHEMBL3656621 IC50 2.0 nM
Cc1ccsc1-c1c2c(nn1C)CCc1cnc(Nc3ccccc3)nc1-2 CHEMBL3656653 IC50 2.0 nM
Cc1ccsc1-c1c2c(nn1C)CCc1cnc(Nc3ccn(CCN(C)C)n3)nc1-2 CHEMBL3656654 IC50 2.0 nM
COCCn1cc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2sccc2C)CC3)cn1 CHEMBL3656655 IC50 2.0 nM
Cn1nc2c(c1-c1ccccc1)-c1nc(Nc3ccn(CCN4CCOCC4)n3)ncc1CC2 CHEMBL3656656 IC50 2.0 nM
COCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2ccccc2Cl)CC3)n1 CHEMBL3656657 IC50 2.0 nM
CN(C)CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2ccccc2Cl)CC3)n1 CHEMBL3656658 IC50 2.0 nM
CC1Cc2nn(C)c(-c3ccccc3)c2-c2nc(Nc3ccn(CCN(C)C)n3)ncc21 CHEMBL3656659 IC50 2.0 nM
CN(C)CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc4ccccc24)CC3)n1 CHEMBL3656660 IC50 2.0 nM
COc1cc(C(=O)NC2CCN(C3CC3)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660917 IC50 2.0 nM
COCCN1CCC(NC(=O)c2ccc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccccc3Cl)CC4)c(OC)c2)CC1 CHEMBL3660918 IC50 2.0 nM
COc1cc(C(=O)N[C@@H]2CCN(C3CCN(C)CC3)C2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660920 IC50 2.0 nM
COc1cc(C(=O)NC2CCC(N(C)C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660921 IC50 2.0 nM
COc1cc(C(=O)NCCN2CCOCC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660924 IC50 2.0 nM
COc1cc(C(=O)NCC(=O)N2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660927 IC50 2.0 nM
COc1cc(C(=O)NC2CC(N3CCOCC3)C2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660933 IC50 2.0 nM
COc1cc(C(=O)NC2CCN(CC3CC3)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2C CHEMBL3660935 IC50 2.0 nM
COc1cc(C(=O)N[C@H]2CC[C@H](N3CCOCC3)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2C CHEMBL3660938 IC50 2.0 nM
COc1cc(C(=O)N[C@@H]2CCC(C3CCOCC3)C2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2C CHEMBL3660943 IC50 2.0 nM
CN1CCC(NC(=O)c2ccc(Nc3ncc4c(n3)-c3c(nn(C)c3Cc3ccccc3)CC4)c(Cl)c2)CC1 CHEMBL3660953 IC50 2.0 nM
COc1cc(C(=O)N[C@@H]2CCN(C3CCOCC3)C2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660963 IC50 2.0 nM
COc1cc(C(=O)NC2CN(C)C2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1)CC2 CHEMBL3660966 IC50 2.0 nM
COc1cc(C(=O)N[C@H]2CC[C@H](N3CCN(CC4CC4)CC3)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660978 IC50 2.0 nM
CC1Cc2nn(C)c(Cc3ccccc3Cl)c2-c2nc(Nc3cnn(C4CCNCC4)c3)ncc21 CHEMBL3661003 IC50 2.0 nM
CCOc1cc(N2CCN(C(=O)N(C)C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1Cc1ccccc1)CC2 CHEMBL3661015 IC50 2.0 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CC(C)C)c4)cc2)CC3)n1 CHEMBL3942462 IC50 2.0 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4C)cc2)CC3)n1 CHEMBL3918478 IC50 2.0 nM
Cn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(-c4cn[nH]c4)c2)CC3)n1 CHEMBL3947056 IC50 2.0 nM
Cn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(-c4cnn(CC(=O)O)c4)c2)CC3)n1 CHEMBL3972280 IC50 2.0 nM
COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C(C)C)c3)cc1)CC2 CHEMBL3908003 IC50 2.0 nM
COc1cc(N2CCN(S(=O)(=O)N(C)C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3957936 IC50 2.0 nM
CC(=O)N1CCC(n2cc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccc(-c5cnn(C)c5)nc3)CC4)cn2)CC1 CHEMBL3956197 IC50 2.0 nM
CN(C)CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)nc2)CC3)n1 CHEMBL3934053 IC50 2.0 nM
COCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)nc2)CC3)n1 CHEMBL3967306 IC50 2.0 nM
Cn1cc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)nc2)CC3)cn1 CHEMBL3899961 IC50 2.0 nM
COCCn1cc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)nc2)CC3)cn1 CHEMBL3927953 IC50 2.0 nM
Cn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5cnn(CCN6CCOCC6)c5)nc3-4)cn2)cn1 CHEMBL3936949 IC50 2.0 nM
COc1cc(Nc2nccc(Nc3ccc4ccccc4c3)n2)cc(OC)c1OC CHEMBL1760036 IC50 2.2 nM
COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)ccc1N1CCOCC1 CHEMBL1738698 IC50 2.4 nM
COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC CHEMBL1760035 IC50 2.5 nM
CC(=O)N1CCN([C@H]2C[C@@H](n3cc(-c4cccc(OCC56CCC(CC5)O6)c4F)c4c(N)ncnc43)C2)CC1 CHEMBL3785376 IC50 2.8 nM
COc1cc(N2CCC(N3CCN(C(C)=O)CC3)CC2)ccc1Nc1nccc(-c2c(-c3cccc(C(=O)Nc4c(F)cccc4F)c3)nc3ccccn23)n1 CHEMBL447639 IC50 3.0 nM
CCN(C)CC(=O)N1CCc2cc(OC)c(Nc3nc(Nc4cccc(F)c4C(N)=O)c4cc[nH]c4n3)cc21 CHEMBL464344 IC50 3.0 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1ncc(Br)c(-c2cnc3ccccn23)n1 CHEMBL1809194 IC50 3.0 nM
O=C(Nc1ncns1)[C@@H]1C[C@H](O)CN1c1nc(Nc2cc(C3CC3)n[nH]2)c2cccn2n1 CHEMBL3655755 IC50 3.0 nM
O=C(Nc1ncns1)[C@@H]1C[C@H](F)CN1c1nc(Nc2cc(C3CC3)n[nH]2)c2cccn2n1 CHEMBL3655761 IC50 3.0 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3652816 IC50 3.0 nM
CC1Cc2nn(C)c(-c3ccccc3Cl)c2-c2nc(Nc3ccn(C(C)C)n3)ncc21 CHEMBL3652839 IC50 3.0 nM
Cc1cc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccccc2Cl)CC3C)[n+](C)[nH]1 CHEMBL4108861 IC50 3.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccsc1)CC2 CHEMBL3656636 IC50 3.0 nM
COCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2sccc2C)CC3)n1 CHEMBL3656661 IC50 3.0 nM
Cn1nc2c(c1-c1ccccc1)-c1nc(Nc3ccn(CCN4CCCC4)n3)ncc1CC2 CHEMBL3656662 IC50 3.0 nM
COCCN(C)CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccccc2)CC3)n1 CHEMBL3656663 IC50 3.0 nM
CC(=O)N1CCC(n2cc(Nc3ncc4c(n3)-c3c(nn(C)c3Cc3ccccc3)CC4)cn2)CC1 CHEMBL3656664 IC50 3.0 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2ccccc2)CC3)n1 CHEMBL3656665 IC50 3.0 nM
CN(C)CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccccc2)CC3)n1 CHEMBL3656666 IC50 3.0 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2cccc(Cl)c2)CC3)n1 CHEMBL3656667 IC50 3.0 nM
CN(C)CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2cccc(Cl)c2)CC3)n1 CHEMBL3656668 IC50 3.0 nM
COCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccccc2)CC3C)n1 CHEMBL3656669 IC50 3.0 nM
CC(=O)N1CCC(n2cc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccc(OC(F)F)cc3)CC4)cn2)CC1 CHEMBL3656670 IC50 3.0 nM
COc1cccc(Cc2c3c(nn2C)CCc2cnc(Nc4cnn(CCN(C)C)c4)nc2-3)c1 CHEMBL3656671 IC50 3.0 nM
COc1ccc(-c2c3c(nn2C)CCc2cnc(Nc4cnn(C)c4)nc2-3)cc1 CHEMBL3656672 IC50 3.0 nM
CCN1CCC(NC(=O)c2ccc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccccc3)CC4)c(OC)c2)CC1 CHEMBL3660907 IC50 3.0 nM
COc1cc(C(=O)NC2CC3CC(C)CC(C2)N3)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1)CC2 CHEMBL3660908 IC50 3.0 nM
COc1cc(C(=O)NC2CC(N3CCN(CCF)CC3)C2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660929 IC50 3.0 nM
COc1cc(C(=O)NC2CCN(Cc3cccnc3)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660930 IC50 3.0 nM
COc1cc(C(=O)NC2CCN(CC3CC3)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660931 IC50 3.0 nM
COc1cc(C(=O)N[C@H]2CC[C@H](N3CCN(CC4CC4)CC3)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2C CHEMBL3660940 IC50 3.0 nM
COc1cc(C(=O)NC2CCN(CC(N)=O)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660962 IC50 3.0 nM
COc1cc(C(=O)NCCN(C)C)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1C)CC2 CHEMBL3660968 IC50 3.0 nM
COc1cc(C(=O)NCCCN(C)C)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1C)CC2 CHEMBL3660974 IC50 3.0 nM
COCCNC(=O)c1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccccc2Cl)CC3)c(OC)c1 CHEMBL3660979 IC50 3.0 nM
Cc1cc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C(C)C)c4)cc2)CC3)nn1C CHEMBL3958299 IC50 3.0 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4c[nH]nc4C)cc2)CC3)n1 CHEMBL3927269 IC50 3.0 nM
CCCn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccc(C(=O)O)cc5OC)nc3-4)cc2)cn1 CHEMBL3977232 IC50 3.0 nM
CCn1cc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)nc2)CC3)cn1 CHEMBL3912514 IC50 3.0 nM
CCCN1CCC=C(c2ccc(Nc3nc(Nc4cc(F)ccc4C(N)=O)c4cc[nH]c4n3)c(OC(C)C)c2)C1 CHEMBL473669 IC50 3.2 nM
COc1cc(N2CCN(C(C)C)CC2)c(OC)cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 CHEMBL475286 IC50 3.2 nM
CNC(=O)c1cc(F)ccc1Nc1nc(Nc2ccc(N3CCN(C(C)C)CC3)cc2OC)nc2[nH]ccc12 CHEMBL515602 IC50 3.2 nM
COc1cc(N2CCC(N(C)C)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3397300 IC50 3.2 nM
COc1cc(Nc2nccc(Nc3ccc4ncccc4c3)n2)cc(OC)c1OC CHEMBL1760041 IC50 3.3 nM
COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)ccc1OCCCN1CCCCC1 CHEMBL1760058 IC50 3.8 nM
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCCC4=O)c3)n2)c1 CHEMBL1991429 pKi 3.981 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl CHEMBL458997 pKi 3.981 nM
COc1c(Nc2nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n2)ccc(N2CCN(C(C)C)CC2)c1F CHEMBL473254 IC50 4.0 nM
COc1ccc(N2CCN(C(C)C)CC2)cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 CHEMBL516816 IC50 4.0 nM
O=C(Nc1c(F)cccc1F)c1cccc(-c2nc3ccccn3c2-c2ccnc(Nc3ccc(CCN4CCOCC4)cc3)n2)c1 CHEMBL500003 IC50 4.0 nM
COc1cc(N2CCC(N3C[C@@H](C)O[C@@H](C)C3)CC2)ccc1Nc1nccc(-c2c(-c3cccc(C(=O)Nc4c(F)cccc4F)c3)nc3ccccn23)n1 CHEMBL454796 IC50 4.0 nM
COc1cc2c(cc1Nc1nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN)CC2 CHEMBL517729 IC50 4.0 nM
COc1cc2c(cc1Nc1nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n1)N(C(=O)CCN1CCN(C(C)C)CC1)CC2 CHEMBL450919 IC50 4.0 nM
CN(C)CCNC(=O)c1ccc(-c2cnc3[nH]cc(-c4cccc(NC(=O)Nc5ccccc5Oc5ccccc5)c4)c3c2)cc1 CHEMBL564255 IC50 4.0 nM
CN(C)CCNC(=O)c1cccc(-c2cnc3[nH]cc(-c4cccc(NC(=O)Nc5ccccc5Oc5ccccc5)c4)c3c2)c1 CHEMBL542008 IC50 4.0 nM
C[C@@]1(C(=O)Nc2nccs2)CCCN1c1nc(Nc2cc(C3CC3)n[nH]2)c2cccn2n1 CHEMBL577385 IC50 4.0 nM
Nc1ccccc1NC(=O)[C@H]1CC[C@H](c2nc(-c3ccc4ccc(-c5ccccc5)nc4c3F)c3c(N)nccn32)CC1 CHEMBL1667947 IC50 4.0 nM
COc1cc(N2CC3CNCC(C2)O3)ccc1Nc1ncc(Cl)c(-c2cnc3ccccn23)n1 CHEMBL1809058 IC50 4.0 nM
CNCC(=O)N1CCN(c2ccc(Nc3ncc(Cl)c(-c4cnc5ccccn45)n3)c(OC)c2)CC1 CHEMBL1809073 IC50 4.0 nM
COc1cc(-c2ccccc2)nc2c(F)c(-c3nc([C@H]4C[C@@](C)(O)C4)n4ccnc(N)c34)ccc12 CHEMBL3037912 IC50 4.0 nM
COc1ccc(NC(=O)/C=C/CN(C)C)cc1Nc1ncc(Cl)c(-c2cnn3ccccc23)n1 CHEMBL2426288 IC50 4.0 nM
CCOc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1Cc1ccccc1)CC2 CHEMBL3652815 IC50 4.0 nM
Cc1cc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccccc2Cl)CC3C)nn1C CHEMBL3652840 IC50 4.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1C(C)c1ccccc1)CC2 CHEMBL3652850 IC50 4.0 nM
COc1ccc(-c2c3c(nn2C)CCc2cnc(Nc4ccccc4)nc2-3)c(Cl)c1 CHEMBL3656607 IC50 4.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1C(C)C)CC2 CHEMBL3656624 IC50 4.0 nM
CN(C)CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2ccccc2)CC3)n1 CHEMBL3656673 IC50 4.0 nM
Cn1cc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccccc2)CC3)cn1 CHEMBL3656674 IC50 4.0 nM
COCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(OC(F)F)c2)CC3)n1 CHEMBL3656675 IC50 4.0 nM
COCCn1cc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2ccccc2C)CC3)cn1 CHEMBL3656676 IC50 4.0 nM
Cc1cccc(Cc2c3c(nn2C)CCc2cnc(Nc4ccn(CCN(C)C)n4)nc2-3)c1 CHEMBL3656677 IC50 4.0 nM
CC(=O)N1CCC(n2cc(Nc3ncc4c(n3)-c3c(nn(C)c3Cc3cccc(C)c3)CC4)cn2)CC1 CHEMBL3656678 IC50 4.0 nM
COc1cc(C(=O)N[C@H]2CN3CCC2CC3)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1)CC2 CHEMBL3660903 IC50 4.0 nM
COc1cc(C(=O)NCCCN(C)C)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1)CC2 CHEMBL3660905 IC50 4.0 nM
COc1cc(C(=O)NC2CCN(Cc3ccncc3)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660928 IC50 4.0 nM
CN(C)CCNC(=O)c1cc2cccc(Nc3ncc4c(n3)-c3c(nn(C)c3Cc3ccccc3)CC4)c2s1 CHEMBL3660959 IC50 4.0 nM
COc1cc(C(=O)NC2CCN(CCO)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1C)CC2 CHEMBL3660969 IC50 4.0 nM
COc1cc(C(=O)NC2CCN(C3CCOCC3)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1C)CC2 CHEMBL3660972 IC50 4.0 nM
COc1cc(C(=O)NC2CN(C)C2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1C)CC2 CHEMBL3660975 IC50 4.0 nM
COc1cc(C(=O)N[C@@H]2CN3CCC2CC3)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1)CC2 CHEMBL3660990 IC50 4.0 nM
Cn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(C)n5)nc3-4)cn2)cn1 CHEMBL3928623 IC50 4.0 nM
CN1CCN([C@H]2CC[C@H](n3nc(-c4ccc(Nc5nc6cccc(Cl)c6o5)cc4Cl)c4c(N)ncnc43)CC2)CC1 CHEMBL1256435 pIC50 4.074 nM
Nc1ncnc2c1c(-c1cccc(OCC34CCC(CC3)O4)c1F)cn2[C@H]1C[C@@H](CN2CC[S+]([O-])CC2)C1 CHEMBL3787360 IC50 4.3 nM
CCCN1CCC=C(c2ccc(Nc3nc(Nc4ccccc4C(N)=O)c4cc[nH]c4n3)c(C)c2)C1 CHEMBL513897 IC50 5.0 nM
CNC(=O)c1c(F)cccc1Nc1nc(Nc2ccc(N3CCN(C(C)C)CC3)cc2OC)nc2[nH]ccc12 CHEMBL475074 IC50 5.0 nM
COc1cc(N2CCN(C(C)C)CC2)ccc1Nc1nc(Nc2ccc(F)cc2C(=O)NCCO)c2cc[nH]c2n1 CHEMBL505983 IC50 5.0 nM
COc1cc(N2CCC(N3CCN(S(C)(=O)=O)CC3)CC2)ccc1Nc1nccc(-c2c(-c3cccc(C(=O)Nc4c(F)cccc4F)c3)nc3ccccn23)n1 CHEMBL507714 IC50 5.0 nM
COc1cc(N2CCC(N3CCN(S(C)(=O)=O)CC3)CC2)ccc1Nc1nc(Nc2ccsc2C(N)=O)c2cc[nH]c2n1 CHEMBL1964269 IC50 5.0 nM
CNC(=O)[C@H]1CC[C@H](c2nc(-c3ccc4ccc(-c5ccccc5)nc4c3F)c3c(N)nccn32)CC1 CHEMBL1667939 IC50 5.0 nM
Nc1nccn2c1c(-c1ccc3ccc(-c4ccccc4)nc3c1F)nc2[C@H]1CC[C@H](C(=O)Nc2nncs2)CC1 CHEMBL1667941 IC50 5.0 nM
Nc1nccn2c1c(-c1ccc3ccc(-c4ccccc4)nc3c1F)nc2[C@H]1CC[C@H](C(=O)Nc2ccn[nH]2)CC1 CHEMBL1667942 IC50 5.0 nM
Nc1nccn2c1c(-c1ccc3ccc(-c4ccccc4)nc3c1F)nc2[C@H]1CC[C@H](C(=O)Nc2ccccn2)CC1 CHEMBL1667945 IC50 5.0 nM
COc1cc(C2CCNCC2)ccc1Nc1ncc(Cl)c(-c2cnc3ccccn23)n1 CHEMBL1809046 IC50 5.0 nM
COc1cc(N2CCN(C(=O)CN)CC2)ccc1Nc1ncc(Cl)c(-c2cnc3ccccn23)n1 CHEMBL1809072 IC50 5.0 nM
COc1cc(N2CCN(C(=O)[C@H](C)N)CC2)ccc1Nc1ncc(Cl)c(-c2cnc3ccccn23)n1 CHEMBL1809074 IC50 5.0 nM
CCOc1cc(-c2ccccc2)nc2c(F)c(-c3nc([C@H]4C[C@@](C)(O)C4)n4ccnc(N)c34)ccc12 CHEMBL3037913 IC50 5.0 nM
Cc1nn(C2CCN(C(=O)[C@@H](C)N)CC2)c(C)c1Nc1ncc(Cl)c(-c2cnn3ccccc23)n1 CHEMBL3822644 IC50 5.0 nM
O=C(Nc1nccs1)[C@@H]1C[C@@H](O)CN1c1nc(Nc2cc(C3CC3)n[nH]2)c2cccn2n1 CHEMBL3655749 IC50 5.0 nM
CC(C)N1CCCC(NC(=O)C2C[C@H](O)CN2c2nc(Nc3cn(C(C)C)cn3)c3cccn3n2)C1 CHEMBL3655751 IC50 5.0 nM
CC1(c2cc(Nc3nc(N4C[C@H](F)C[C@H]4C(=O)Nc4ncns4)nn4cccc34)[nH]n2)CC1 CHEMBL3655758 IC50 5.0 nM
COc1cc(OCCN2CCCC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1)CC2 CHEMBL3652823 IC50 5.0 nM
CC1Cc2nn(C)c(-c3ccccc3Cl)c2-c2nc(Nc3ccccc3)ncc21 CHEMBL3652828 IC50 5.0 nM
COc1ccc(Cc2c3c(nn2C)CCc2cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc2-3)cc1 CHEMBL3656538 IC50 5.0 nM
COc1cc(OCCN2CCCC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccsc1)CC2 CHEMBL3656679 IC50 5.0 nM
COc1cc(OCCN2CCCC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1C(C)C)CC2C CHEMBL3656680 IC50 5.0 nM
COc1cccc(Cc2c3c(nn2C)CCc2cnc(Nc4ccn(C)n4)nc2-3)c1 CHEMBL3656681 IC50 5.0 nM
COCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2ccccc2)CC3)n1 CHEMBL3656682 IC50 5.0 nM
CC(C)n1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2ccccc2Cl)CC3)n1 CHEMBL3656683 IC50 5.0 nM
COc1ccccc1Cc1c2c(nn1C)CCc1cnc(Nc3ccn(CCN(C)C)n3)nc1-2 CHEMBL3656684 IC50 5.0 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccccc2)CC3C)n1 CHEMBL3656685 IC50 5.0 nM
CN(C)CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(OC(F)F)cc2)CC3)n1 CHEMBL3656686 IC50 5.0 nM
Cn1nc2c(c1Cc1ccccc1Cl)-c1nc(Nc3ccn(Cc4ccncc4)n3)ncc1CC2 CHEMBL3656687 IC50 5.0 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(C)c2)CC3)n1 CHEMBL3656688 IC50 5.0 nM
COCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(C)c2)CC3)n1 CHEMBL3656689 IC50 5.0 nM
CN(C)CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(Cl)c2)CC3)n1 CHEMBL3656690 IC50 5.0 nM
COCCN1CCC(NC(=O)c2ccc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccccc3)CC4)c(OC)c2)CC1 CHEMBL3660909 IC50 5.0 nM
COc1cc(C(=O)NC2CCN(CCO)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1)CC2 CHEMBL3660910 IC50 5.0 nM
COc1cc(C(=O)NC2CCN(C3CC3)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1)CC2 CHEMBL3660911 IC50 5.0 nM
CCOc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1Cc1ccccc1)CC2 CHEMBL3660952 IC50 5.0 nM
CCOc1cc(C(=O)NC2CCN(C3CC3)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1Cc1ccccc1)CC2 CHEMBL3660955 IC50 5.0 nM
COCCN1CCC(NC(=O)c2ccc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccccc3C)CC4)c(OC)c2)CC1 CHEMBL3660971 IC50 5.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1C(C)C)CC2C CHEMBL3660999 IC50 5.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1Cc1c(Cl)cccc1Cl)CC2 CHEMBL3661000 IC50 5.0 nM
Cc1ccccc1-c1c2c(nn1C)CCc1cnc(Nc3ccc(OC4CCN(C)CC4)cc3Cl)nc1-2 CHEMBL3661018 IC50 5.0 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4c(C)n[nH]c4C)cc2)CC3)n1 CHEMBL3899238 IC50 5.0 nM
CN(C)CCn1cc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)nc2)CC3)cn1 CHEMBL3937557 IC50 5.0 nM
O=C(NN=Cc1ccc(O)cc1O)Nc1cccc2nsnc12 CHEMBL1999811 pKi 5.012 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 5.012 nM
COc1cc(Nc2nccc(Nc3cc4ccccc4cn3)n2)cc(OC)c1OC CHEMBL1760040 IC50 5.2 nM
O=C(NCc1nc(Nc2cc(C3CC3)n[nH]2)c2cccn2n1)c1ccc(F)nc1 CHEMBL1222855 IC50 5.3 nM
COc1cc(N2CCN(C(C)C)CC2)ccc1Nc1nc(-n2[nH]c(=O)c3ccccc32)c2cc[nH]c2n1 CHEMBL1964270 IC50 6.0 nM
COc1cc2c(cc1Nc1nc(Nc3ccsc3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN(C)C)CCC2 CHEMBL456252 IC50 6.0 nM
CCCN1CCC(Oc2ccc(OC)c(Nc3nc(Nc4cccc(F)c4C(N)=O)c4cc[nH]c4n3)c2)CC1 CHEMBL464347 IC50 6.0 nM
COc1cc2c(cc1Nc1nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n1)N(C(C)=O)CC2 CHEMBL460815 IC50 6.0 nM
COc1cc2c(cc1Nc1nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n1)N(C(=O)CCN1CCOCC1)CC2 CHEMBL507810 IC50 6.0 nM
C[C@@]1(C(=O)Nc2cccnc2)CCCN1c1nc(Nc2cc(C3CC3)[nH]n2)c2cccn2n1 CHEMBL572581 IC50 6.0 nM
Nc1nccn2c1c(-c1ccc3ccc(-c4ccccc4)nc3c1F)nc2[C@H]1CC[C@H](C(N)=O)CC1 CHEMBL1667940 IC50 6.0 nM
Nc1nccn2c1c(-c1ccc3ccc(-c4ccccc4)nc3c1F)nc2[C@H]1CC[C@H](C(=O)Nc2nc3ccccc3[nH]2)CC1 CHEMBL1667948 IC50 6.0 nM
COc1cc(C2CCN(C(C)=O)CC2)ccc1Nc1ncc(Cl)c(-c2cnc3ccccn23)n1 CHEMBL1809045 IC50 6.0 nM
COc1cc(N2CCN(C(=O)[C@@H](C)N)CC2)ccc1Nc1ncc(Cl)c(-c2cnc3ccccn23)n1 CHEMBL1809075 IC50 6.0 nM
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(-c3cnn4ccccc34)n2)c(OC)cc1N(C)CCN(C)C CHEMBL3353404 IC50 6.0 nM
CC(=O)N1CCC(n2cc(Nc3ncc(Cl)c(-c4cnn5ccccc45)n3)c(C)n2)CC1 CHEMBL3822989 IC50 6.0 nM
Cc1nn(C2CCN(C(=O)CN)CC2)c(C)c1Nc1ncc(Cl)c(-c2cnn3ccccc23)n1 CHEMBL3823154 IC50 6.0 nM
CNCC(=O)N1CCC(n2nc(C)c(Nc3ncc(Cl)c(-c4cnn5ccccc45)n3)c2C)CC1 CHEMBL3822976 IC50 6.0 nM
Cc1cc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccccc2Cl)CC3)nn1C CHEMBL3656575 IC50 6.0 nM
CN(C)CCn1cc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2ccccc2)CC3)cn1 CHEMBL3656691 IC50 6.0 nM
COCCn1cc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2ccccc2)CC3)cn1 CHEMBL3656692 IC50 6.0 nM
CC(C)n1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2ccccc2)CC3)n1 CHEMBL3656693 IC50 6.0 nM
COCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccccc2)CC3)n1 CHEMBL3656694 IC50 6.0 nM
COc1ccccc1Cc1c2c(nn1C)CCc1cnc(Nc3cnn(C4CCN(C(C)=O)CC4)c3)nc1-2 CHEMBL3656695 IC50 6.0 nM
CC(=O)N1CCC(n2cc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3cccc(Cl)c3)CC4)cn2)CC1 CHEMBL3656696 IC50 6.0 nM
CC(=O)N1CCC(n2cc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3cccc(C)c3)CC4)cn2)CC1 CHEMBL3656697 IC50 6.0 nM
CN(C)CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(F)cc2)CC3)n1 CHEMBL3656698 IC50 6.0 nM
COc1ccc(-c2c3c(nn2C)CCc2cnc(Nc4ccn(C)n4)nc2-3)cc1 CHEMBL3656699 IC50 6.0 nM
CN(C)CCn1cc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(OC(F)F)cc2)CC3)cn1 CHEMBL3656700 IC50 6.0 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(OC(F)F)cc2)CC3)n1 CHEMBL3656701 IC50 6.0 nM
Cn1cc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(Cl)cc2)CC3)cn1 CHEMBL3656702 IC50 6.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc2c(n1)-c1c(nn(C)c1C(C)C)CC2 CHEMBL3660946 IC50 6.0 nM
Cc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1C)CC2 CHEMBL3660960 IC50 6.0 nM
COc1cc(C(=O)NC2CCN(Cc3ccccc3)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1Cl)CC2 CHEMBL3660964 IC50 6.0 nM
COc1cc(C(=O)N[C@H]2CC[C@H](N3CCOCC3)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1C)CC2 CHEMBL3660967 IC50 6.0 nM
CN(C)CCCNC(=O)c1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccccc2Cl)CC3)c(Cl)c1 CHEMBL3660982 IC50 6.0 nM
Cc1ccccc1-c1c2c(nn1C)CCc1cnc(Nc3ccc(C(=O)NCCN(C)C)cc3Cl)nc1-2 CHEMBL3660983 IC50 6.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2C(=O)N(C)C)n1 CHEMBL3823016 IC50 6.17 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2I)n1 CHEMBL3822664 IC50 6.2 nM
COc1cc(N2CCN(C(C)C)CC2)ccc1Nc1nc(Nc2ccc(F)cc2C(=O)NO)c2cc[nH]c2n1 CHEMBL475482 IC50 6.3 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 6.31 nM
O=C(Nc1c(F)cccc1F)c1cccc(-c2nc3ccccn3c2-c2ccnc(Nc3ccc4c(c3)OCCO4)n2)c1 CHEMBL444031 IC50 7.0 nM
CCc1cc(Nc2nccc(-c3c(-c4cccc(C(=O)Nc5c(F)cccc5F)c4)nc4ccccn34)n2)c(OC)cc1N1CCC(N2CCN(S(C)(=O)=O)CC2)CC1 CHEMBL448929 IC50 7.0 nM
O=C(c1ccc(F)nc1)N1CCC[C@H]1c1nc(Nc2cc(C3CC3)[nH]n2)c2cccn2n1 CHEMBL1222710 IC50 7.0 nM
CC(=O)Nc1cc(CN2C(=O)N(c3ccc(SC(F)(F)F)cc3)C(=O)C2(C)C)ccn1 CHEMBL1762178 IC50 7.0 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1ncc(Cl)c(-c2cnc3ccc(F)cn23)n1 CHEMBL1809224 IC50 7.0 nM
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(-c3cnn4ccccc34)n2)c(OC)cc1N1CC[C@@H](N(C)C)C1 CHEMBL3353403 IC50 7.0 nM
C[C@@]1(C(=O)Nc2ccncn2)CCCN1c1nc(Nc2cc(C3CC3)[nH]n2)c2cccn2n1 CHEMBL3655739 IC50 7.0 nM
Cc1ccccc1-c1c2c(nn1C)CCc1cnc(Nc3ccccc3)nc1-2 CHEMBL3656543 IC50 7.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1C1CCC1)CC2 CHEMBL3656593 IC50 7.0 nM
Cc1cccc(Cc2c3c(nn2C)CCc2cnc(Nc4cnn(C)c4)nc2-3)c1 CHEMBL3656703 IC50 7.0 nM
COc1cc(C(=O)NCCN(C)C)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1)CC2 CHEMBL3660902 IC50 7.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(Cl)cc1Nc1ncc2c(n1)-c1c(nn(C)c1C(C)C)CC2 CHEMBL3660949 IC50 7.0 nM
Cc1ccccc1-c1c2c(nn1C)CCc1cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3Cl)nc1-2 CHEMBL3660981 IC50 7.0 nM
Cc1ccccc1-c1c2c(nn1C)CCc1cnc(Nc3ccc(C(=O)NC4CN(C)C4)cc3Cl)nc1-2 CHEMBL3660988 IC50 7.0 nM
Cc1ccccc1-c1c2c(nn1C)CCc1cnc(Nc3ccc(OCCN(C)C)cc3Cl)nc1-2 CHEMBL3661019 IC50 7.0 nM
Cc1ccccc1-c1c2c(nn1C)CCc1cnc(Nc3ccc(OCCCN4CCCC4)cc3Cl)nc1-2 CHEMBL3661021 IC50 7.0 nM
COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(CC(C)C)c3)cc1)CC2 CHEMBL3965466 IC50 7.0 nM
C=CC(=O)NCCOCCNC(=O)CCN1CCC(c2cc(OC(C)C)c(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)cc2C)CC1 CHEMBL4753933 IC50 7.1 nM
Nc1ncnc2c1c(-c1cc(OCC34CCC(CC3)O4)ccc1F)cn2[C@H]1C[C@@H](CN2CC[S+]([O-])CC2)C1 CHEMBL3786100 IC50 7.3 nM
CN1CCN([C@H]2CC[C@H](n3nc(-c4ccc(Nc5nc6cccc(Cl)c6o5)c(F)c4)c4c(N)ncnc43)CC2)CC1 CHEMBL1256432 IC50 7.5 nM
CC(=O)N1CCN([C@H]2C[C@@H](n3cc(-c4cc(OCC56CCC(CC5)O6)ccc4F)c4c(N)ncnc43)C2)CC1 CHEMBL3787271 IC50 7.8 nM
COc1cc(N2CCN(C(C)C)CC2)ccc1Nc1nc2[nH]ccc2c2nc3cccc(F)c3c(=O)n12 CHEMBL457322 IC50 7.9 nM
COc1c(Nc2nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n2)ccc(N2CCN(C(C)C)CC2)c1C CHEMBL515909 IC50 8.0 nM
COc1ccc(OCCCN(C)C)cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 CHEMBL459753 IC50 8.0 nM
COc1cc2c(cc1Nc1nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n1)N(C(=O)CCN(C)C)CC2 CHEMBL517340 IC50 8.0 nM
Nc1nccn2c1c(-c1ccc3ccc(-c4ccccc4)nc3c1F)nc2[C@H]1CC[C@H](CO)CC1 CHEMBL1667936 IC50 8.0 nM
Nc1nccn2c1c(-c1ccc3ccc(-c4ccccc4)nc3c1F)nc2[C@H]1CC[C@H](C(=O)Nc2ccncn2)CC1 CHEMBL1667946 IC50 8.0 nM
Nc1ncnn2c1c(-c1ccc3ccc(-c4ccccc4)nc3c1F)nc2[C@H]1C[C@@H](N2CCN(C=O)CC2)C1 CHEMBL1688361 IC50 8.0 nM
COc1cc(N2CCN(C(N)=O)CC2)ccc1Nc1ncc(Cl)c(-c2cnc3ccccn23)n1 CHEMBL1809067 IC50 8.0 nM
COc1cc(N2CCN(C(=O)CO)CC2)ccc1Nc1ncc(Cl)c(-c2cnc3ccccn23)n1 CHEMBL1809069 IC50 8.0 nM
COc1ccn2c(-c3nc(Nc4ccc(N5CCN(C(C)=O)CC5)cc4OC)ncc3Cl)cnc2c1 CHEMBL1809206 IC50 8.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCNCC1 CHEMBL2403108 IC50 8.0 nM
C[C@]1(O)C[C@@H](c2nc(-c3ccc4c(Oc5ccccc5)cc(-c5ccccc5)nc4c3F)c3c(N)nccn32)C1 CHEMBL3037915 IC50 8.0 nM
CC(=O)N1CCC(n2ncc(Nc3ncc(Cl)c(-c4cnn5ccccc45)n3)c2C)CC1 CHEMBL3823301 IC50 8.0 nM
Cc1nn(C2CCN(C(=O)[C@H](C)N)CC2)c(C)c1Nc1ncc(Cl)c(-c2cnn3ccccc23)n1 CHEMBL3824103 IC50 8.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1C(C)(C)C)CC2 CHEMBL3656628 IC50 8.0 nM
COCCn1cc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2ccccc2Cl)CC3)cn1 CHEMBL3656704 IC50 8.0 nM
COCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2ccccc2OC)CC3)n1 CHEMBL3656705 IC50 8.0 nM
CN(C)CCn1cc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(Cl)cc2)CC3)cn1 CHEMBL3656706 IC50 8.0 nM
CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(Cl)c2)CC3)n1 CHEMBL3656707 IC50 8.0 nM
COCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(Cl)c2)CC3)n1 CHEMBL3656708 IC50 8.0 nM
CC(=O)N1CCC(n2cc(Nc3ncc4c(n3)-c3c(nn(C)c3Cc3cccc(Cl)c3)CC4)cn2)CC1 CHEMBL3656709 IC50 8.0 nM
COc1cc(C(=O)NCCN2CCCC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1)CC2 CHEMBL3660904 IC50 8.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(C)cc1Nc1ncc2c(n1)-c1c(nn(C)c1C(C)C)CC2 CHEMBL3660947 IC50 8.0 nM
COCCN1CCC(NC(=O)c2cc(OC)c(Nc3ncc4c(n3)-c3c(nn(C)c3C(C)C)CC4)cc2Cl)CC1 CHEMBL3660950 IC50 8.0 nM
COc1cc(C(=O)NC2CCN(C3CC3)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1C)CC2 CHEMBL3660976 IC50 8.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccsc1)CC2 CHEMBL3661001 IC50 8.0 nM
Cc1ccccc1-c1c2c(nn1C)CCc1cnc(Nc3ccc(OCC(C)(C)N(C)C)cc3Cl)nc1-2 CHEMBL3661020 IC50 8.0 nM
COc1cc(C2CCN(C)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3823190 IC50 8.2 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2OC)n1 CHEMBL3823045 IC50 8.7 nM
CCN1CCN(CCCOc2cc3ncc(C#N)c(Nc4ccc(Sc5nc(C)c(C)n5CC)c(Cl)c4)c3cc2OC)CC1 CHEMBL447167 IC50 9.0 nM
Cc1cc(N2CCC(N3CCN(C(=O)N4CCOCC4)CC3)CC2)cc2[nH]c(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL459118 IC50 9.0 nM
O=C(Nc1cccnc1)[C@@H]1CCCN1c1nc(Nc2cc(C3CC3)[nH]n2)c2cccn2n1 CHEMBL573246 IC50 9.0 nM
Cc1ccc(N2CCC(N3CCN(C(=O)N4CCOCC4)CC3)CC2)c2[nH]c(-c3c(N[C@@H](CO)Cc4ccccc4Br)cc[nH]c3=O)nc12 CHEMBL590049 IC50 9.0 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1ncc(Cl)c(-c2cnc3ccccn23)n1 CHEMBL1809044 IC50 9.0 nM
COc1cc(N2CCN(S(C)(=O)=O)CC2)ccc1Nc1ncc(Cl)c(-c2cnc3ccccn23)n1 CHEMBL1809065 IC50 9.0 nM
COc1cc(N2CCN(C(=O)[C@H](C)O)CC2)ccc1Nc1ncc(Cl)c(-c2cnc3ccccn23)n1 CHEMBL1809070 IC50 9.0 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1ncc(Cl)c(-c2cnc3cc(C)ccn23)n1 CHEMBL1809205 IC50 9.0 nM
CCOc1cc(-c2ccccc2)nc2c(F)c(-c3nc([C@H]4C[C@@H](N5CCN(C)CC5)C4)n4ccnc(N)c34)ccc12 CHEMBL3037921 IC50 9.0 nM
COc1cc(-c2ccccc2)nc2c(F)c(-c3nc([C@H]4C[C@@H](N5CCN(C)CC5)C4)n4ccnc(N)c34)ccc12 CHEMBL3037920 IC50 9.0 nM
CC1(C)CC[C@@H](COc2cccc(-c3cn([C@H]4C[C@@H](CN5CCC5)C4)c4ncnc(N)c34)c2)O1 CHEMBL3786567 IC50 9.0 nM
Cc1nn(C2CCN(CCO)CC2)c(C)c1Nc1ncc(Cl)c(-c2cnn3ccccc23)n1 CHEMBL3824323 IC50 9.0 nM
Cc1nn(C2CCN(CC(=O)N(C)C)CC2)c(C)c1Nc1ncc(Cl)c(-c2cnn3ccccc23)n1 CHEMBL3823095 IC50 9.0 nM
CCOc1nn(C2CCN(C(C)=O)CC2)cc1Nc1ncc(Cl)c(-c2cnn3ccccc23)n1 CHEMBL3822943 IC50 9.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1C1CCCCC1)CC2 CHEMBL3652845 IC50 9.0 nM
COc1ccc(Cc2c3c(nn2C)CCc2cnc(Nc4ccc(OCCN5CCCC5)cc4OC)nc2-3)cc1 CHEMBL3656536 IC50 9.0 nM
Cc1cccc(-c2c3c(nn2C)CCc2cnc(Nc4ccn(CCN(C)C)n4)nc2-3)c1 CHEMBL3656710 IC50 9.0 nM
COCCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(F)cc2)CC3)n1 CHEMBL3656711 IC50 9.0 nM
COc1cc(C(=O)NC2CCN(C3CCOCC3)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1)CC2 CHEMBL3660912 IC50 9.0 nM
COc1cc(C(=O)N[C@H]2CC[C@H](N3CCOCC3)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccccc1)CC2 CHEMBL3660989 IC50 9.0 nM
CC(=O)N1CCN([C@H]2C[C@@H](n3cc(-c4cccc(OCC56CCC(CC5)O6)c4)c4c(N)ncnc43)C2)CC1 CHEMBL3787636 IC50 9.4 nM
O=C(Nc1ccc(F)nc1)[C@@H]1CCC[C@H]1c1nc(Nc2cc(C3CC3)[nH]n2)c2cccn2n1 CHEMBL1222791 IC50 9.7 nM