CNc1nccc(-c2cc3cc(C(=O)N[C@@H](CN(c4ccccc4)c4ccccn4)C(=O)O)ccc3[nH]2)n1 CHEMBL3897289 IC50 0.08 nM
Cn1cc(CN2CCN(c3cc(C(=O)Nc4ccc5c(c4)-c4c(c(C(N)=O)nn4-c4ccc(F)cc4)CC5)c(Cl)cn3)C(C(=O)O)C2)cn1 CHEMBL1669569 IC50 0.5 nM
NC(=O)c1nn(-c2ccc(F)cc2)c2c1CCc1ccc(NC(=O)c3cc(N4CCN(Cc5cnn(CC(=O)O)c5)CC4)ncc3Cl)cc1-2 CHEMBL1669608 IC50 0.5 nM
NC(=O)c1nn(-c2ccc(F)cc2)c2c1CCc1ccc(NC(=O)c3cc(N4CCC(O)CC4)ncc3Cl)cc1-2 CHEMBL1669562 IC50 0.6 nM
COCCNc1cc(C(=O)Nc2ccc3c(c2)-c2c(c(C(N)=O)nn2-c2ccc(F)cc2)CC3)c(Cl)cn1 CHEMBL1669563 IC50 0.6 nM
CNc1nccc(-c2cc3cc(C(=O)N[C@@H](CN(c4ccccc4)c4ccccn4)C(=O)NOC)ccc3[nH]2)n1 CHEMBL3915686 IC50 0.8 nM
NC(=O)Cn1cc(CN2CCN(c3cc(C(=O)Nc4ccc5c(c4)-c4c(c(C(N)=O)nn4-c4ccc(F)cc4)CC5)c(Cl)cn3)CC2)cn1 CHEMBL1669599 IC50 0.9 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.9 nM
CCOC(=O)Cn1cc(CN2CCN(c3cc(C(=O)Nc4ccc5c(c4)-c4c(c(C(N)=O)nn4-c4ccc(F)cc4)CC5)c(Cl)cn3)CC2)cn1 CHEMBL1669565 IC50 1.0 nM
NC(=O)c1nn(-c2ccc(F)cc2)c2c1CCc1ccc(NC(=O)c3cc(N4CCN(Cc5cnn(CC(=O)NCCO)c5)CC4)ncc3Cl)cc1-2 CHEMBL1669605 IC50 1.0 nM
COC(=O)Cn1cc(CN2CCN(c3cc(C(=O)Nc4ccc5c(c4)-c4c(c(C(N)=O)nn4-c4ccc(F)cc4)CC5)c(Cl)cn3)CC2)cn1 CHEMBL1669596 IC50 1.1 nM
CN1CCN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3cccc(O)c3)CC4)c(Cl)cn2)CC1 CHEMBL1669551 IC50 1.2 nM
COCCOC(=O)Cn1cc(CN2CCN(c3cc(C(=O)Nc4ccc5c(c4)-c4c(c(C(N)=O)nn4-c4ccc(F)cc4)CC5)c(Cl)cn3)CC2)cn1 CHEMBL1669597 IC50 1.3 nM
COCCNC(=O)Cn1cc(CN2CCN(c3cc(C(=O)Nc4ccc5c(c4)-c4c(c(C(N)=O)nn4-c4ccc(F)cc4)CC5)c(Cl)cn3)CC2)cn1 CHEMBL1669603 IC50 1.3 nM
CNC(=O)Cn1cc(CN2CCN(c3cc(C(=O)Nc4ccc5c(c4)-c4c(c(C(N)=O)nn4-c4ccc(F)cc4)CC5)c(Cl)cn3)CC2)cn1 CHEMBL1669600 IC50 1.4 nM
CN1CCN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc(F)cc3)CC4)c(Cl)cn2)CC1 CHEMBL592893 IC50 1.6 nM
COCCN1CCN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc(F)cc3)CC4)c(Cl)cn2)CC1 CHEMBL601079 IC50 1.9 nM
NC(=O)c1nn(-c2ccc(F)cc2)c2c1CCc1ccc(NC(=O)c3cc(N4CCN(Cc5cn[nH]c5)CC4)ncc3Cl)cc1-2 CHEMBL1669571 IC50 1.9 nM
O=C1Nc2nc(-c3c(O)cccc3OCC3CC3)cc([C@@H]3CCCNC3)c2CO1 CHEMBL516203 Ki 2.0 nM
CC(C)NC(=O)Cn1cc(CN2CCN(c3cc(C(=O)Nc4ccc5c(c4)-c4c(c(C(N)=O)nn4-c4ccc(F)cc4)CC5)c(Cl)cn3)CC2)cn1 CHEMBL1669601 IC50 2.0 nM
CN1CCN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc(Cl)c(O)c3)CC4)c(Cl)cn2)CC1 CHEMBL1669560 IC50 2.2 nM
NC(=O)c1nn(-c2ccc(F)cc2)c2c1CCc1ccc(NC(=O)c3cc(N4CCN(Cc5cnn(CCCO)c5)CC4)ncc3Cl)cc1-2 CHEMBL1669595 IC50 2.2 nM
CN(C)C(=O)Cn1cc(CN2CCN(c3cc(C(=O)Nc4ccc5c(c4)-c4c(c(C(N)=O)nn4-c4ccc(F)cc4)CC5)c(Cl)cn3)CC2)cn1 CHEMBL1669602 IC50 2.3 nM
CSCCNC(=O)Cn1cc(CN2CCN(c3cc(C(=O)Nc4ccc5c(c4)-c4c(c(C(N)=O)nn4-c4ccc(F)cc4)CC5)c(Cl)cn3)CC2)cn1 CHEMBL1669604 IC50 2.5 nM
Cc1cnc2c(NCCN)nc3cc(-c4ccc[nH]4)sc3n12 CHEMBL250105 pIC50 2.512 nM
CN1CCN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc(O)c(Cl)c3)CC4)c(Cl)cn2)CC1 CHEMBL1669559 IC50 2.8 nM
Cc1c(CN2CCN(c3cc(C(=O)Nc4ccc5c(c4)-c4c(c(C(N)=O)nn4-c4ccc(F)cc4)CC5)c(Cl)cn3)CC2)cnn1C CHEMBL1669568 IC50 2.8 nM
COCCCn1cc(CN2CCN(c3cc(C(=O)Nc4ccc5c(c4)-c4c(c(C(N)=O)nn4-c4ccc(F)cc4)CC5)c(Cl)cn3)CC2)cn1 CHEMBL1669593 IC50 2.8 nM
N#Cc1c(C2CCCNC2)cc(-c2c(O)cccc2OCC2CC2)nc1N CHEMBL182407 IC50 3.0 nM
CNc1nc2cc(-c3cccc(CNS(N)(=O)=O)c3)sc2n2c(C)cnc12 CHEMBL249280 IC50 3.0 nM
Cn1cc(CN2CCN(c3cc(C(=O)Nc4ccc5c(c4)-c4c(c(C(N)=O)nn4-c4ccc(F)cc4)CC5)c(Cl)cn3)CC2)cn1 CHEMBL1669552 IC50 3.0 nM
CN(C)CCCNC(=O)Cn1cc(CN2CCN(c3cc(C(=O)Nc4ccc5c(c4)-c4c(c(C(N)=O)nn4-c4ccc(F)cc4)CC5)c(Cl)cn3)CC2)cn1 CHEMBL1669607 IC50 3.3 nM
CN1CCN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc(O)cc3)CC4)c(Cl)cn2)CC1 CHEMBL1669558 IC50 3.5 nM
CC1CN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc(F)cc3)CC4)c(Cl)cn2)CCN1Cc1cnn(C)c1 CHEMBL1669554 IC50 3.5 nM
CN(C)CCCn1cc(CN2CCN(c3cc(C(=O)Nc4ccc5c(c4)-c4c(c(C(N)=O)nn4-c4ccc(F)cc4)CC5)c(Cl)cn3)CC2)cn1 CHEMBL1669555 IC50 3.7 nM
CNc1nccc(-c2cc3cc(C(=O)N[C@@H](CN(c4ccccc4)c4ncccn4)C(=O)O)ccc3[nH]2)n1 CHEMBL3946903 IC50 3.8 nM
Cn1cc(CN2CCN(c3cc(C(=O)Nc4ccc5c(c4)-c4c(c(C(N)=O)nn4-c4ccc(F)cc4)CC5)c(Cl)cn3)CC2C(=O)O)cn1 CHEMBL1669570 IC50 3.9 nM
O=S1(=O)CCC(NS(=O)(=O)c2ccc(-c3ccnc4[nH]c(C5CC5)cc34)cc2)CC1 CHEMBL2164412 pIC50 3.981 nM
N#Cc1c(C2CCCNC2)cc(-c2c(O)cccc2OCC2CCC2)nc1N CHEMBL183703 pIC50 3.981 nM
CCn1cc(CN2CCN(c3cc(C(=O)Nc4ccc5c(c4)-c4c(c(C(N)=O)nn4-c4ccc(F)cc4)CC5)c(Cl)cn3)CC2)cn1 CHEMBL1669572 IC50 4.2 nM
Cc1nn(C)cc1CN1CCN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc(F)cc3)CC4)c(Cl)cn2)CC1 CHEMBL1669567 IC50 4.3 nM
CCOC(=O)CCn1cc(CN2CCN(c3cc(C(=O)Nc4ccc5c(c4)-c4c(c(C(N)=O)nn4-c4ccc(F)cc4)CC5)c(Cl)cn3)CC2)cn1 CHEMBL1669598 IC50 4.7 nM
CN1CCN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3cccc(F)c3)CC4)c(Cl)cn2)CC1 CHEMBL1669556 IC50 4.8 nM
CCCOc1cccc(O)c1-c1cc(C2CCCNC2)c(C#N)c(N)n1 CHEMBL181334 IC50 5.0 nM
CC(C)COc1cccc(O)c1-c1cc(C2CCCNC2)c(C#N)c(N)n1 CHEMBL181495 IC50 5.0 nM
CNc1nc2sc(-c3cccc(CNS(C)(=O)=O)c3)nc2c2c1ncn2C CHEMBL493974 IC50 5.0 nM
CCOC(=O)Cn1cc(CN2CCN(c3cc(C(=O)Nc4ccc5c(c4)-c4c(c(C(N)=O)nn4-c4cccc(F)c4)CC5)c(Cl)cn3)CC2)cn1 CHEMBL1669566 IC50 5.0 nM
CNc1nc2[nH]c(-c3cccc(CNC(=O)CCN(C)C)n3)cc2c2c1ncn2C CHEMBL1923988 IC50 5.0 nM
CCc1cc2c(-c3ccc(S(=O)(=O)NC4CCS(=O)(=O)CC4)cc3)ccnc2[nH]1 CHEMBL2164410 pIC50 5.012 nM
CNC(=O)N(C)Cc1cccc(-c2cc3c(nc(NC)c4ncn(C)c43)[nH]2)n1 CHEMBL1921823 IC50 5.7 nM
CCCCCOc1cccc(O)c1-c1cc(C2CCCNC2)c(C#N)c(N)n1 CHEMBL182749 IC50 6.0 nM
CNc1nc2sc(-c3ccccc3)nc2c2c1ncn2C CHEMBL521643 IC50 6.0 nM
CNc1nc2sc(-c3cccc([C@H](C)NC(C)=O)c3)nc2c2c1ncn2C CHEMBL1642545 IC50 6.0 nM
COc1ccc(-n2nc(C(N)=O)c3c2-c2cc(NC(=O)c4cc(N5CCN(C)CC5)ncc4Cl)ccc2CC3)cc1 CHEMBL1669561 IC50 6.1 nM
CC(C)(O)CNS(=O)(=O)c1ccc(-c2ccnc3[nH]c(C4CC4)cc23)cc1 CHEMBL2164424 pIC50 6.31 nM
CC(C)c1cc2c(-c3ccc(S(=O)(=O)NC4CCS(=O)(=O)CC4)cc3)ccnc2[nH]1 CHEMBL2164411 pIC50 6.31 nM
NC(=O)c1cc(-c2ccccc2)cc2c(C3CCN(S(=O)(=O)CCCN4CCCCCC4)CC3)c[nH]c12 CHEMBL4522601 pIC50 6.31 nM
COCCOCCCn1cc(CN2CCN(c3cc(C(=O)Nc4ccc5c(c4)-c4c(c(C(N)=O)nn4-c4ccc(F)cc4)CC5)c(Cl)cn3)CC2)cn1 CHEMBL1669594 IC50 6.6 nM
CNc1nc2cc(-c3cccc(CCNS(N)(=O)=O)c3)sc2n2c(C)cnc12 CHEMBL249482 IC50 7.0 nM
CNC1=Nc2cc(-c3cccc(CCNS(N)(=O)=O)c3)sc2N2C(C)=CNC12 CHEMBL1831199 IC50 7.0 nM
CNc1nc2[nH]c(-c3cccc(F)c3)cc2c2c1ncn2C CHEMBL549478 pIC50 7.079 nM
CNc1nc2[nH]c(-c3cccc(C#N)c3)cc2c2c1ncn2C CHEMBL558491 pIC50 7.079 nM
N#CCCn1cc(CN2CCN(c3cc(C(=O)Nc4ccc5c(c4)-c4c(c(C(N)=O)nn4-c4ccc(F)cc4)CC5)c(Cl)cn3)CC2)cn1 CHEMBL1669573 IC50 7.6 nM
CCc1ccc(-c2cc(C(N)=O)c(NC(N)=O)s2)cc1 CHEMBL1761516 pIC50 7.943 nM
C[C@@H](CO)NS(=O)(=O)c1ccc(-c2ccnc3[nH]c(C4CC4)cc23)cc1 CHEMBL2164426 pIC50 7.943 nM
O=S(=O)(NCCO)c1ccc(-c2ccnc3[nH]c(C4CC4)cc23)cc1 CHEMBL2164422 pIC50 7.943 nM
CC(C)c1cc2c(-c3ccc(S(=O)(=O)NCCO)cc3)ccnc2[nH]1 CHEMBL2164421 pIC50 7.943 nM
CC(C)(C)c1cc2c(-c3ccc(S(=O)(=O)NC4CCS(=O)(=O)CC4)cc3)ccnc2[nH]1 CHEMBL2164413 pIC50 7.943 nM
CNc1nc2[nH]c(-c3cccc(OC)c3)cc2c2c1ncn2C CHEMBL551773 pIC50 7.943 nM
Cc1cnc2c(NCCN)nc3cc(-c4cccc(CO)c4)sc3n12 CHEMBL249104 pIC50 7.943 nM
CNC1=Nc2cc(-c3cccc(CC(N)=O)c3)sc2N2C(C)=CNC12 CHEMBL1831200 pIC50 7.943 nM
NC(=O)c1cc(-c2ccccc2)cc2c(C3CCN(S(=O)(=O)CCCN4CCCCC4)CC3)c[nH]c12 CHEMBL4462412 pIC50 7.943 nM
NCCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4ccccc4)cc23)CC1 CHEMBL4457925 pIC50 7.943 nM
NC(=O)c1cc(-c2ccccc2)cc2c(C3CCN(S(=O)(=O)CCN4CCOCC4)CC3)c[nH]c12 CHEMBL4473469 pIC50 7.943 nM
CC1(C)CC(c2c[nH]c3c(C(N)=O)cc(-c4ccccc4)cc23)CCS1(=O)=O CHEMBL4577079 pIC50 7.943 nM
CC1(C)C[C@H](c2c[nH]c3c(C(N)=O)cc(-c4ccc(F)cc4)cc23)CCS1(=O)=O CHEMBL4565091 pIC50 7.943 nM
CNc1nc2cc(-c3cccc(CC(N)=O)c3)sc2n2c(C)cnc12 CHEMBL399486 IC50 8.0 nM
C#C/N=C(\NCCCCCCOc1ccc(Cl)cc1)Nc1ccncc1 CHEMBL474802 IC50 8.0 nM
COc1cccc2nc(-c3cccs3)nc(NN3C(=O)C=C(C)C3=O)c12 CHEMBL129857 IC50 8.0 nM
CNc1nc2cc(-c3cccc(CC(C)=O)c3)sc2n2c(C)cnc12 CHEMBL1831076 IC50 8.0 nM
CNc1nc2cc(-c3cccc(CN)c3)sc2n2c(C)cnc12 CHEMBL400077 IC50 8.0 nM
N#Cc1c(C2CCNCC2)cc(-c2c(O)cccc2OCC2CC2)nc1N CHEMBL368427 IC50 8.5 nM
CNC1=Nc2cc(-c3cccc(CN)c3)sc2N2C(C)=CNC12 CHEMBL1831201 IC50 8.5 nM
C#Cc1c(C2CCNCC2)cc(-c2c(O)cccc2OCC2CC2)nc1N CHEMBL2375673 pIC50 8.511 nM
N#Cc1c(C2CCCNC2)cc(-c2c(O)cccc2OCc2ccccc2)nc1N CHEMBL361233 IC50 9.0 nM
CNc1nc2sc(-c3cccc(C(C)NC(C)=O)c3)nc2c2c1ncn2C CHEMBL1642549 IC50 9.0 nM
CNC1=Nc2cc(-c3cccc(CCC(=O)O)c3)sc2N2C(C)=CNC12 CHEMBL1831202 IC50 9.0 nM
CNc1nc2[nH]c(-c3cccc(C(C)NC(C)=O)n3)cc2c2c1ncn2C CHEMBL1923973 IC50 9.0 nM
CNc1nc2[nH]c(-c3cccc(CNC(=O)COC)n3)cc2c2c1ncn2C CHEMBL1923983 IC50 9.0 nM
Cc1cnc2c(NCCN)nc3cc(-c4cn[nH]c4)sc3n12 CHEMBL250106 IC50 10.0 nM
NC(=O)c1nn(-c2ccc(F)cc2)c2c1CCc1ccc(NC(=O)c3cc(N4CCNCC4)ncc3Cl)cc1-2 CHEMBL610730 IC50 10.0 nM
CC(C)(C)CC(=O)Nc1ccc(-c2ccnc(Nc3ccc(S(N)(=O)=O)cc3)n2)cc1 CHEMBL1082834 IC50 10.0 nM
CCNc1nc2sc(-c3cccc([C@H](C)NC(=O)C4CCN(C)CC4)c3)nc2c2c1ncn2C CHEMBL1642564 IC50 10.0 nM
CN1CCN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc(F)c(F)c3)CC4)c(Cl)cn2)CC1 CHEMBL1669557 IC50 10.0 nM
Cc1cc2c(-c3ccc(S(=O)(=O)NCC(C)(C)O)cc3)ccnc2[nH]1 CHEMBL2164425 pIC50 10.0 nM
NC(=O)c1cc(-c2ccccc2)cc2c(C3CCN(S(=O)(=O)CCCN4CCCC4)CC3)c[nH]c12 CHEMBL4436805 pIC50 10.0 nM
CN(C)CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4ccccc4)cc23)CC1 CHEMBL4529539 pIC50 10.0 nM
NC(=O)c1cc(-c2ccccc2)cc2c(C3CCS(=O)(=O)CC3)c[nH]c12 CHEMBL4590548 pIC50 10.0 nM
NC(=O)c1nn(-c2ccc(F)cc2)c2c1CCc1ccc(NC(=O)c3cc(N4CCN(Cc5cnn(CC(=O)N(CCO)CCO)c5)CC4)ncc3Cl)cc1-2 CHEMBL1669606 IC50 10.2 nM
CNc1nc2oc(-c3ccccc3)nc2c2c1ncn2C CHEMBL493940 pIC50 10.96 nM
CNc1nc2[nH]c(-c3cccc(CN)c3)cc2c2c1ncn2C CHEMBL562720 pIC50 10.96 nM
CNc1nc2cc3ccccc3cc2c2c(C)cnn12 CHEMBL390201 pIC50 10.96 nM
NS(=O)(=O)c1ccc(Nc2nccc(-c3ccc(S(=O)(=O)N4CCNCC4)cc3)n2)cc1 CHEMBL131693 pIC50 10.96 nM
N#Cc1c(C2CCNCC2)cc(-c2c(O)cccc2OCC2CCC2)nc1N CHEMBL361841 IC50 12.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 12.0 nM
O=C(c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1)N(Cc1ccccc1)C[C@@H]1C[C@@H](F)CN1 CHEMBL1669334 IC50 12.0 nM
CNc1nc2[nH]c(-c3cccc(CNC(=O)CCOC)n3)cc2c2c1ncn2C CHEMBL1923984 IC50 12.0 nM
CNc1nc2[nH]c(-c3cccc(CNC(=O)C(C)(C)O)n3)cc2c2c1ncn2C CHEMBL1923986 IC50 12.0 nM
CNc1nc2[nH]c(-c3cccc(CNC(=O)CCOC)c3)cc2c2c1ncn2C CHEMBL562971 pIC50 12.02 nM
CCCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4ccccc4)cc23)CC1 CHEMBL1761512 pIC50 12.59 nM
Cc1cc2c(-c3ccc(S(=O)(=O)NC4CCS(=O)(=O)CC4)nc3)ccnc2[nH]1 CHEMBL2164417 pIC50 12.59 nM
NC(=O)c1cc(-c2ccc(F)cc2)cc2c(C3CCS(=O)(=O)CC3)c[nH]c12 CHEMBL4564744 pIC50 12.59 nM
CNc1nc2cc(-c3cccc(CCNCC(N)=O)c3)sc2n2c(C)cnc12 CHEMBL398253 pIC50 12.88 nM
NC(=O)Nc1sc(-c2ccccc2)cc1C(N)=O CHEMBL404609 pIC50 12.88 nM
CNc1nc2cc(-c3cccc(CC(N)C(=O)O)c3)sc2n2c(C)cnc12 CHEMBL249886 pIC50 12.88 nM
CC(=O)N[C@@H](C)c1cccc(-c2nc3c(nc(N)c4ncn(C)c43)s2)c1 CHEMBL1642547 IC50 13.0 nM
O=C(c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1)N(C/C=C/c1ccccc1)C[C@@H]1C[C@@H](F)CN1 CHEMBL1669337 IC50 13.0 nM
CNc1nc2[nH]c(-c3cccc(CNC(=O)CO)n3)cc2c2c1ncn2C CHEMBL1923985 IC50 13.0 nM
CCOc1cccc(O)c1-c1cc(C2CCCNC2)c(C#N)c(N)n1 CHEMBL182173 IC50 14.0 nM
CCCCCCCOc1cccc(O)c1-c1cc(C2CCCNC2)c(C#N)c(N)n1 CHEMBL181756 IC50 14.0 nM
CNc1nc2cc(-c3cccc(C[C@H](N)C(N)=O)c3)sc2n2c(C)cnc12 CHEMBL399689 IC50 14.0 nM
Cc1ccc(-n2nc(C(N)=O)c3c2-c2cc(NC(=O)c4cc(N5CCN(C)CC5)ncc4Cl)ccc2CC3)cc1 CHEMBL1669553 IC50 14.0 nM
Cn1cc(CN2CCN(c3cc(C(=O)Nc4ccc5c(c4)-c4c(c(C(N)=O)nn4-c4cccc(F)c4)CC5)c(Cl)cn3)CC2)cn1 CHEMBL1669564 IC50 14.0 nM
CNc1nc2[nH]c(-c3cccc(CN(C)C(C)=O)n3)cc2c2c1ncn2C CHEMBL1923975 IC50 14.0 nM
CNc1nc2[nH]c(-c3cccc(CNC(C)=O)c3)cc2c2c1ncn2C CHEMBL552183 IC50 14.0 nM
CNc1nc2sc(-c3cccc([C@@H](C)NC(=O)c4ccccc4S(C)(=O)=O)c3)nc2c2c1ncn2C CHEMBL4287153 IC50 14.0 nM
N#Cc1c(C2CCCNC2)cc(-c2c(O)cccc2O)nc1N CHEMBL182358 IC50 15.0 nM
CCCCOc1cccc(O)c1-c1cc(C2CCNCC2)c(C#N)c(N)n1 CHEMBL360337 IC50 15.0 nM
CC(C)COc1cccc(O)c1-c1cc(C2CCNCC2)c(C#N)c(N)n1 CHEMBL181434 IC50 15.0 nM
CNC(=O)c1nc2c(nc(NC)c3ncn(C)c32)s1 CHEMBL504727 IC50 15.0 nM
CCNC(=O)c1nc2c(nc(NC)c3ncn(C)c32)s1 CHEMBL492527 IC50 15.0 nM
CNc1nc2sc(C(=O)NCc3cccs3)nc2c2c1ncn2C CHEMBL492755 IC50 15.0 nM
O=C(c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1)N(CCO)C[C@@H]1C[C@@H](F)CN1 CHEMBL1669340 IC50 15.0 nM
CC(=O)Nc1ccc(CN(C[C@@H]2C[C@@H](F)CN2)C(=O)c2ccc(-c3cnc4ccc(NCC5CC5)nn34)cc2)cc1 CHEMBL1669342 IC50 15.0 nM
Cc1cc2c(-c3ccc(S(=O)(=O)N(C)CCO)cc3)ccnc2[nH]1 CHEMBL520308 IC50 15.0 nM
CNC(=O)c1ccc(-c2nc3c(nc(NC)c4ncn(C)c43)s2)cc1 CHEMBL2375543 pIC50 15.14 nM
CNc1nc2sc(-c3ccc(C(=O)NCc4cccs4)cc3)nc2c2c1ncn2C CHEMBL2375677 pIC50 15.14 nM
CCNC(=O)c1ccc(-c2nc3c(nc(NC)c4ncn(C)c43)s2)cc1 CHEMBL2375676 pIC50 15.14 nM
Cc1cc2c(-c3ccc(NS(=O)(=O)CCN)cc3)ccnc2[nH]1 CHEMBL520473 pIC50 15.85 nM
O=S(=O)(NCCO)c1ccc(-c2ccnc3[nH]c(C(F)(F)F)cc23)cc1 CHEMBL2164420 pIC50 15.85 nM
O=S1(=O)CCC(NS(=O)(=O)c2ccc(-c3ccnc4[nH]c(Cn5ccnn5)cc34)cc2)CC1 CHEMBL2164416 pIC50 15.85 nM
O=S1(=O)CCC(NS(=O)(=O)c2ccc(-c3ccnc4[nH]c(C5CCNCC5)cc34)cc2)CC1 CHEMBL2164415 pIC50 15.85 nM
CNc1nc2sc(-c3cccc(CNC(=O)c4csnn4)c3)nc2c2c1ncn2C CHEMBL522014 pIC50 15.85 nM
CCN(CC)CCCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4ccccc4)cc23)CC1 CHEMBL4536493 pIC50 15.85 nM
CCNc1nc2sc(-c3cccc([C@H](C)NC(=O)COCC)c3)nc2c2c1ncn2C CHEMBL1642559 IC50 16.0 nM
CCCN(C[C@@H]1C[C@@H](F)CN1)C(=O)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1 CHEMBL1669333 IC50 16.0 nM
O=C(NC[C@@H]1C[C@@H](F)CN1)c1ccc(-c2cnc3ccc(NC4CCCC4)nn23)cc1F CHEMBL1807619 IC50 16.0 nM
CNc1nccc(-c2cc3cc(C(=O)N[C@@H](CN(c4ccccc4)c4ccccn4)C(=O)OC)ccc3[nH]2)n1 CHEMBL3949606 IC50 16.8 nM
O=C(c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1)N(Cc1cccc(Cl)c1)C[C@@H]1C[C@@H](F)CN1 CHEMBL1669335 IC50 17.0 nM
O=C(c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1)N(Cc1ccc(Cl)cc1)C[C@@H]1C[C@@H](F)CN1 CHEMBL1669336 IC50 17.0 nM
O=C(O)c1ccc(CN(C[C@@H]2C[C@@H](F)CN2)C(=O)c2ccc(-c3cnc4ccc(NCC5CC5)nn34)cc2)cc1 CHEMBL1669341 IC50 17.0 nM
O=C(NC[C@@H]1C[C@@H](F)CN1)c1ccc(-c2cnc3ccc(NC4CCC4)nn23)cc1F CHEMBL1807618 IC50 17.0 nM
Cc1cnc2c(NCCO)nc3cc4ccccc4cc3n12 CHEMBL230184 IC50 18.0 nM
CNc1nc2cc3ccccc3cc2n2c(C)cnc12 CHEMBL231530 IC50 18.0 nM
CNc1nc2cc(-c3cccc(CCNC(N)=O)c3)sc2n2c(C)cnc12 CHEMBL249481 IC50 18.0 nM
NC(=O)Nc1sc(-c2ccc(F)cc2)cc1C(N)=O CHEMBL257167 IC50 18.0 nM
NC(=O)NC1=C(C(N)=O)C=C(c2ccc(F)cc2)C1 CHEMBL602534 IC50 18.0 nM
CCN(C[C@@H]1C[C@@H](F)CN1)C(=O)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1 CHEMBL1669332 IC50 18.0 nM
CNc1nc2cc(-c3cccc(CCC(N)=O)c3)sc2n2c(C)cnc12 CHEMBL399688 IC50 19.0 nM
Cc1cnc2c(NCCN)nc3cc(-c4ccccc4)sc3n12 CHEMBL249901 IC50 19.0 nM
CN(C)CCN(C)c1cc(C(=O)Nc2ccc3c(c2)-c2c(c(C(N)=O)nn2-c2ccc(F)cc2)CC3)c(Cl)cn1 CHEMBL589338 IC50 19.0 nM
Cc1ccc(-c2ccnc(Nc3ccc(S(N)(=O)=O)cc3)n2)s1 CHEMBL569998 IC50 19.0 nM
CCNc1nc2sc(-c3cccc([C@H](C)NC(C)=O)c3)nc2c2c1ncn2C CHEMBL1642546 IC50 19.0 nM
CCCCNc1ccc2ncc(-c3ccc(C(=O)NC[C@@H]4C[C@@H](F)CN4)c(F)c3)n2n1 CHEMBL1807616 IC50 19.0 nM
COc1c(Cl)cc2c([nH]c3cnccc32)c1NC(=O)c1cccnc1C CHEMBL608154 Kd 19.0 nM
CNc1nc2[nH]c(-c3cccc(CNC(C)=O)n3)cc2c2c1ncn2C CHEMBL1923972 IC50 19.0 nM
CNc1nc2[nH]c(-c3cccc(CN(C)C(=O)COC)n3)cc2c2c1ncn2C CHEMBL1923989 IC50 19.0 nM
NCCNS(=O)(=O)c1ccc(-c2ccnc3[nH]c(CC(N)=O)cc23)cc1 CHEMBL519965 pIC50 19.95 nM
Cc1cc2c(-c3ccc(S(=O)(=O)NCCN)cc3)ccnc2[nH]1 CHEMBL482747 pIC50 19.95 nM
Cc1cc2c(-c3ccc(S(=O)(=O)NCCO)cc3)ccnc2[nH]1 CHEMBL483557 pIC50 19.95 nM
Cc1cc2c(-c3ccc(S(=O)(=O)NC4CCS(=O)(=O)CC4)cc3)ccnc2[nH]1 CHEMBL483165 pIC50 19.95 nM
CC(C)S(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4ccccc4)cc23)CC1 CHEMBL1761513 pIC50 19.95 nM
C[C@@H](CO)NS(=O)(=O)c1ccc(-c2ccnc3[nH]c(C(F)(F)F)cc23)cc1 CHEMBL2164427 pIC50 19.95 nM
CC(C)(C)c1cc2c(-c3ccc(S(=O)(=O)NCCO)cc3)ccnc2[nH]1 CHEMBL2164423 pIC50 19.95 nM
CN(C)Cc1cc2c(-c3ccc(S(=O)(=O)NC4CCS(=O)(=O)CC4)cc3)ccnc2[nH]1 CHEMBL2164414 pIC50 19.95 nM
CCCCCOc1cccc(O)c1-c1cc(C2CCNCC2)c(C#N)c(N)n1 CHEMBL361548 pIC50 19.95 nM
NC(=O)c1cc(-c2ccccc2)cc2c(C3CCN(S(=O)(=O)CCCNC4CCCC4)CC3)c[nH]c12 CHEMBL4522110 pIC50 19.95 nM
CC1(C)CC(c2c[nH]c3c(C(N)=O)cc(-c4ccccc4)cc23)NC1=O CHEMBL4552331 pIC50 19.95 nM
NS(=O)(=O)c1ccc(Nc2nccc(-c3ccc(NC(=O)Cc4cccs4)cc3)n2)cc1 CHEMBL1085122 IC50 20.0 nM
CCNc1nc2sc(-c3cccc([C@H](C)NC(=O)C4CCNCC4)c3)nc2c2c1ncn2C CHEMBL1642565 IC50 20.0 nM
CNc1nc2[nH]c(-c3cccc(NCCOC)n3)cc2c2c1ncn2C CHEMBL1923991 IC50 20.0 nM
Cc1cnc2c(NCCN)nc3cc(-c4cccc(CCO)c4)sc3n12 CHEMBL249515 pIC50 20.89 nM
CNc1nc2cc(-c3cccc(CCNC(C)=O)c3)sc2n2c(C)cnc12 CHEMBL249480 pIC50 20.89 nM
O=C(NC[C@H]1NCC[C@@H]1F)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1 CHEMBL1669328 IC50 21.0 nM
CNC1=Nc2cc(-c3ccccc3)sc2N2C(C)=CNC12 CHEMBL1831203 pIC50 21.88 nM
CNc1nc2[nH]c(-c3cccc(CNC(=O)CCC(N)=O)c3)cc2c2c1ncn2C CHEMBL562370 pIC50 21.88 nM
CNc1nc2sc(-c3cccc(CNC(C)=O)c3)nc2c2c1ncn2C CHEMBL454973 pIC50 21.88 nM
O=C(NC[C@@H]1C[C@@H](F)CN1)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1 CHEMBL1669329 IC50 22.0 nM
Cc1cnc2c(NCCN)nc3cc(-c4ccc(CO)cc4)sc3n12 CHEMBL249508 pIC50 22.91 nM
CNc1nc2cc(-c3cccc(CNCC(N)=O)c3)sc2n2c(C)cnc12 CHEMBL428754 pIC50 22.91 nM
CNCCNc1nc2cc3ccccc3cc2n2c(C)cnc12 CHEMBL249899 pIC50 22.91 nM
CNCCNc1nc2cc3ccccc3cc2n2c(C)cnc12 CHEMBL536520 IC50 23.0 nM
CO[C@H]1CCN[C@@H]1CNC(=O)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1 CHEMBL1669326 IC50 23.0 nM
CNc1nc2[nH]c(-c3cccc(CNC(=O)c4cnccn4)n3)cc2c2c1ncn2C CHEMBL1923981 IC50 23.0 nM
CCCOc1cccc(O)c1-c1cc(C2CCNCC2)c(C#N)c(N)n1 CHEMBL369306 IC50 24.0 nM
N#Cc1c(C2CCCNC2)cc(-c2ccccc2O)nc1N CHEMBL360077 IC50 25.0 nM
CCCCCCOc1cccc(O)c1-c1cc(C2CCNCC2)c(C#N)c(N)n1 CHEMBL360691 IC50 25.0 nM
O=C(c1ccc(Nc2nccc(-c3ccc(CCCCO)s3)n2)cc1)N1CCC(N2CCCC2)CC1 CHEMBL200106 IC50 25.0 nM
CNc1nc2sc(-c3cccc(CNC(=O)c4ccno4)c3)nc2c2c1ncn2C CHEMBL494162 IC50 25.0 nM
CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4ccccc4)cc23)CC1 CHEMBL1761514 pIC50 25.12 nM
NC(=O)Nc1cc(-c2ccccc2)sc1C(N)=O CHEMBL1831214 pIC50 25.12 nM
CNc1nc2[nH]c(-c3cccc(CNC(=O)CO)c3)cc2c2c1ncn2C CHEMBL561447 pIC50 25.12 nM
CC(=O)c1cc2cc(Nc3nccc(-c4ccc(S(=O)(=O)N5CCNCC5)cc4)n3)ccc2o1 CHEMBL2375685 pIC50 25.7 nM
CC(=O)c1cc2cc(-c3ccc(Nc4nccc(-c5ccc(S(=O)(=O)N6CCNCC6)cc5)n4)cc3)ccc2o1 CHEMBL335949 IC50 26.0 nM
N#Cc1c(C2CCCNC2)cc(-c2c(O)cccc2OCC2CCCCC2)nc1N CHEMBL425346 IC50 26.0 nM
CNc1nc2sc(-c3ccc(F)cc3)nc2c2c1ncn2C CHEMBL538910 IC50 26.0 nM
CCCCCNc1ccc2ncc(-c3ccc(C(=O)NC[C@@H]4C[C@@H](F)CN4)c(F)c3)n2n1 CHEMBL1807617 IC50 26.0 nM
CNc1nc2[nH]c(-c3cccc(CNC(=O)CC(C)C)n3)cc2c2c1ncn2C CHEMBL1923980 IC50 26.0 nM
CNc1nc2cc(-c3cccc(C[C@@H](N)C(N)=O)c3)sc2n2c(C)cnc12 CHEMBL249887 pIC50 26.92 nM
CNc1nc2cc(-c3ccccc3)sc2n2c(C)cnc12 CHEMBL249719 IC50 27.0 nM
NC(=O)c1nn(-c2ccc(F)cc2)c2c1CCc1ccc(NC(=O)c3cc(N4CCCNCC4)ncc3Cl)cc1-2 CHEMBL600637 IC50 27.0 nM
CCNc1nc2sc(-c3cccc([C@H](C)NC(=O)CNC(C)=O)c3)nc2c2c1ncn2C CHEMBL1642560 IC50 27.0 nM
O=C(NC[C@@H]1C[C@@H](F)CN1)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1F CHEMBL1807609 IC50 27.0 nM
CNc1nc2sc(SC)nc2c2c1ncn2C CHEMBL505943 IC50 28.0 nM
CNc1nc2sc(-c3cccc([C@@H](C)NC(C)=O)c3)nc2c2c1ncn2C CHEMBL1642550 IC50 28.0 nM
CNc1nc2[nH]c(-c3cccc(CNC(=O)c4csnn4)n3)cc2c2c1ncn2C CHEMBL1923982 IC50 28.0 nM
CNc1nc2sc(-c3ccc(SC)cc3)nc2c2c1ncn2C CHEMBL2375674 pIC50 28.18 nM
Cc1cnc2c(NCCN)nc3cc(-c4ccoc4)sc3n12 CHEMBL249902 pIC50 28.84 nM
CN1CCCN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc(F)cc3)CC4)c(Cl)cn2)CC1 CHEMBL591174 IC50 29.0 nM
O=C(NC[C@@H]1C[C@@H](F)CN1)c1ccc(-c2cnc3ccc(NCCCCCF)nn23)cc1F CHEMBL1807624 IC50 29.0 nM
CS(=O)(=O)c1ccc(Nc2nccc(-c3ccc(S(=O)(=O)N4CCNCC4)cc3)n2)cc1 CHEMBL133548 pIC50 30.9 nM
CNCCNS(=O)(=O)c1ccc(-c2ccnc3[nH]ccc23)cc1 CHEMBL482539 pIC50 31.62 nM
NC(=O)c1cc(-c2ccccc2)cc2c(C3CCN(S(=O)(=O)CCCN4CCOCC4)CC3)c[nH]c12 CHEMBL4465957 pIC50 31.62 nM
CNc1nc2sc(-c3ccc(F)c(CNS(C)(=O)=O)c3)nc2c2c1ncn2C CHEMBL494154 IC50 32.0 nM
CNc1nc2sc(N3CC=CCC3)nc2c2c1ncn2C CHEMBL492331 IC50 33.0 nM
CC(=O)NCCNc1nc2sc(-c3ccc(F)cc3)nc2c2c1ncn2C CHEMBL523692 IC50 33.0 nM
CN1CCN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc5c(c3)OCO5)CC4)c(Cl)cn2)CC1 CHEMBL601077 IC50 33.0 nM
CNc1nc2[nH]c(-c3cccc(CNC(=O)C4CC4)n3)cc2c2c1ncn2C CHEMBL1923978 IC50 33.0 nM
CNc1nc2sc(-c3ccc(N4CC=CCC4)cc3)nc2c2c1ncn2C CHEMBL2375542 pIC50 33.11 nM
COc1cccc(O)c1-c1cc(C2CCCNC2)c(C#N)c(N)n1 CHEMBL363706 pIC50 33.88 nM
CNc1nc2cc(-c3ccccc3)nn2c2c1ncn2C CHEMBL493745 pIC50 33.88 nM
NC(=O)c1nn(-c2ccc3c(c2)OCO3)c2c1CCc1ccc(NC(=O)c3cccnc3Cl)cc1-2 CHEMBL590515 IC50 34.0 nM
CCNc1nc2sc(-c3cccc([C@H](C)NC(=O)C4(C)CC4)c3)nc2c2c1ncn2C CHEMBL1642558 IC50 34.0 nM
NS(=O)(=O)c1ccc(Nc2nccc(-c3ccccc3[N+](=O)[O-])n2)cc1 CHEMBL3924516 IC50 34.0 nM
CNCCNc1nc2cc3ccccc3cc2c2c(C)cnn12 CHEMBL230186 pIC50 34.67 nM
CNC(=O)C(N)Cc1cccc(-c2cc3nc(NC)c4ncc(C)n4c3s2)c1 CHEMBL399368 IC50 36.0 nM
CCNc1nc2sc(-c3cccc(C(C)(C)NC(C)=O)c3)nc2c2c1ncn2C CHEMBL1642557 IC50 36.0 nM
CNc1nc2cc(-c3cccc(CNC(C)=O)c3)sc2n2c(C)cnc12 CHEMBL249279 pIC50 38.02 nM
CNc1nc2[nH]c(-c3cccc(CNC(=O)c4csnn4)c3)cc2c2c1ncn2C CHEMBL560708 pIC50 38.9 nM
CCNc1nc2sc(-c3ccc(F)cc3)nc2c2c1ncn2C CHEMBL493161 pIC50 38.9 nM
CCNCC(=O)N[C@@H](C)c1cccc(-c2nc3c(nc(NCC)c4ncn(C)c43)s2)c1 CHEMBL1642561 IC50 39.0 nM
NCCNS(=O)(=O)c1ccc(-c2ccnc3[nH]ccc23)cc1 CHEMBL473080 pIC50 39.81 nM
O=S(=O)(NC1CNC1)c1ccc(-c2ccnc3[nH]ccc23)cc1 CHEMBL482540 pIC50 39.81 nM
Cc1cc2c(-c3ccc(S(=O)(=O)N(C)C4CCS(=O)(=O)CC4)cc3)ccnc2[nH]1 CHEMBL483166 pIC50 39.81 nM
NC(=O)Nc1cc(-c2cccc(Cl)c2)sc1C(N)=O CHEMBL2375429 pIC50 39.81 nM
N#Cc1c(C(N)Cc2ccc(F)cc2)cc(-c2ccccc2O)nc1N CHEMBL183496 pIC50 39.81 nM
Cc1cnc2c(NCCN3CCNCC3)nc3cc(-c4ccccc4)sc3n12 CHEMBL2375541 pIC50 39.81 nM
CC(C)(N)CCc1ccc(-c2ccnc(Nc3ccc(C(=O)N4CCC(N5CCCC5)CC4)cc3)n2)s1 CHEMBL199837 pIC50 39.81 nM
CNc1nc2[nH]c(-c3ccccc3)cc2c2c1ncn2C CHEMBL565076 pIC50 39.81 nM
O=C(c1ccc(Nc2nccc(-c3cc4ccccc4s3)n2)cc1)N1CCC(N2CCCC2)CC1 CHEMBL200027 pIC50 39.81 nM
NC(=O)c1cc(-c2ccccc2)cc2c(C3CCC(=O)N3)c[nH]c12 CHEMBL4451691 pIC50 39.81 nM
NC(=O)c1cc(-c2ccccc2)cc2c([C@H]3C[C@H]4CC[C@@H](C3)S4(=O)=O)c[nH]c12 CHEMBL4528313 pIC50 39.81 nM
CN(C)C1CCN(C(=O)c2ccc(Nc3nccc(-c4cc5ccccc5s4)n3)cc2)CC1 CHEMBL200229 IC50 40.0 nM
Cc1cnc2c(NCCN3CCCCC3)nc3cc(-c4ccccc4)sc3n12 CHEMBL250336 IC50 40.0 nM
CN(CCOc1ccccc1-c1cc(C(N)=O)c(NC(N)=O)s1)Cc1ccccc1 CHEMBL514980 IC50 40.0 nM
NC(=O)c1nn(-c2ccc3c(c2)OCO3)c2c1CCc1ccc(NC(=O)c3cc(N4CCNCC4)ncc3Cl)cc1-2 CHEMBL590901 IC50 40.0 nM
COc1ccc(-c2ccnc(Nc3ccc(S(N)(=O)=O)cc3)n2)cc1 CHEMBL1082511 IC50 40.0 nM
CC1=CNC2C(NCCN3CCCCC3)=Nc3cc(-c4ccccc4)sc3N12 CHEMBL1831204 IC50 40.0 nM
CCCc1cc(N2CCC(N)CC2)nc2sc(C(N)=O)c(N)c12 CHEMBL578601 IC50 41.0 nM
CCNc1nc2sc(-c3cccc([C@H](C)NC(=O)c4cccc(S(C)(=O)=O)c4)c3)nc2c2c1ncn2C CHEMBL1642563 IC50 41.0 nM
CNc1nc2[nH]c(-c3cccc(CNC(=O)C4(C)CC4)n3)cc2c2c1ncn2C CHEMBL1923979 IC50 41.0 nM
CCCc1cc(N2CCC(O)C(C)(C)C2)nc2sc(C(N)=O)c(N)c12 CHEMBL1204404 IC50 42.0 nM
CN(C[C@@H]1C[C@@H](F)CN1)C(=O)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1 CHEMBL1669331 IC50 42.0 nM
CNc1nc2[nH]c(-c3ccc(F)cc3)cc2c2c1ncn2C CHEMBL549479 pIC50 42.66 nM
CS(=O)(=O)Nc1ccc(Nc2nccc(-c3ccc(S(=O)(=O)N4CCNCC4)cc3)n2)cc1 CHEMBL133823 pIC50 42.66 nM
CNc1nc2cc(-c3cccc(CNC(N)=O)c3)sc2n2c(C)cnc12 CHEMBL400078 pIC50 42.66 nM
O=C(NC[C@@H]1C[C@@H](F)CN1)c1ccc(-c2cnc3ccc(NCCCCF)nn23)cc1F CHEMBL1807623 IC50 43.0 nM
CNc1nc2[nH]c(-c3ccccc3F)cc2c2c1ncn2C CHEMBL556806 pIC50 43.65 nM
N#Cc1ccc(Nc2nccc(-c3ccc(S(=O)(=O)N4CCNCC4)cc3)n2)cc1 CHEMBL132416 pIC50 43.65 nM
COc1cccc(-c2cc3nc(NCCN)c4ncc(C)n4c3s2)c1 CHEMBL249102 pIC50 43.65 nM
CCC(=O)NCc1cccc(-c2cc3c(nc(NC)c4ncn(C)c43)[nH]2)n1 CHEMBL1923976 IC50 44.0 nM
CNc1nc2cc(-c3cccc(CCN)c3)sc2n2c(C)cnc12 CHEMBL437586 pIC50 44.67 nM
C[C@H]1CN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc(F)cc3)CC4)c(Cl)cn2)CCN1C CHEMBL591200 IC50 45.0 nM
Cc1cnc2c(NCCN3CCCCC3)nc3cc4ccccc4cc3n12 CHEMBL230185 pIC50 45.71 nM
CC1CN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc(F)cc3)CC4)c(Cl)cn2)CC(C)N1 CHEMBL590767 IC50 46.0 nM
NC(=O)c1nn(-c2ccc(F)cc2)c2c1CCc1ccc(NC(=O)c3cccnc3Cl)cc1-2 CHEMBL601921 IC50 47.0 nM
O=C(NC[C@@H]1CCCCN1)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1 CHEMBL1223289 IC50 47.0 nM
NC(=O)c1ccc(Nc2nccc(-c3ccc(S(=O)(=O)N4CCNCC4)cc3)n2)cc1 CHEMBL130631 pIC50 47.86 nM
C[C@@H]1CN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc(F)cc3)CC4)c(Cl)cn2)CCN1C CHEMBL601080 IC50 48.0 nM
CC(=O)N[C@@H](C)c1cccc(-c2nc3c(nc(NCCN)c4ncn(C)c43)s2)c1 CHEMBL1642552 IC50 49.0 nM
CCC(F)(F)c1cc(N2CCC(S(C)(=O)=O)CC2)nc2sc(C(N)=O)c(N)c12 CHEMBL4522930 IC50 49.0 nM
CCCCCCCOc1cccc(O)c1-c1cc(C2CCNCC2)c(C#N)c(N)n1 CHEMBL185509 IC50 50.0 nM
CC(C)(O)CCc1ccc(-c2ccnc(Nc3ccc(C(=O)N4CCC(N5CCCC5)CC4)cc3)n2)s1 CHEMBL371543 IC50 50.0 nM
COc1cc(Nc2nccc(-c3cc4ccccc4s3)n2)ccc1C(=O)N1CCC(N2CCCC2)CC1 CHEMBL372736 IC50 50.0 nM
NS(=O)(=O)c1ccc(Nc2nccc(-c3ccc(NC(=O)Cc4ccccc4)cc3)n2)cc1 CHEMBL1084174 IC50 50.0 nM
COc1ccc(-c2cc(NC(N)=O)c(C(N)=O)s2)cc1 CHEMBL1831077 IC50 50.0 nM
CNC(=O)Nc1cc(-c2ccccc2)sc1C(N)=O CHEMBL383723 IC50 50.0 nM
CNC(=O)CNCCc1cccc(-c2cc3nc(NC)c4ncc(C)n4c3s2)c1 CHEMBL249681 IC50 51.0 nM
C[C@H]1CN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc(F)cc3)CC4)c(Cl)cn2)CCN1 CHEMBL601727 IC50 51.0 nM
CCN1CCN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc5c(c3)OCO5)CC4)c(Cl)cn2)CC1 CHEMBL601078 IC50 52.0 nM
CNc1nc2sc(-c3ccc(F)c(CNC(C)=O)c3)nc2c2c1ncn2C CHEMBL494153 IC50 53.0 nM
C[C@@H]1CN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc(F)cc3)CC4)c(Cl)cn2)CCN1 CHEMBL591256 IC50 54.0 nM
O=C(NC[C@@H]1CCCN1)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1 CHEMBL1222990 IC50 55.0 nM
CCNc1nc2sc(-c3cccc([C@@H](C)NC(C)=O)c3)nc2c2c1ncn2C CHEMBL1642556 IC50 55.0 nM
Cn1cnc2c(NCCN3CCCCC3)nc3sc(-c4ccc(F)cc4)nc3c21 CHEMBL521679 IC50 56.0 nM
CC(=O)N[C@@H](C)c1cccc(-c2nc3c(nc(NCC(F)(F)F)c4ncn(C)c43)s2)c1 CHEMBL1642551 IC50 57.0 nM
Cn1cnc2c(NCCN)nc3cc4ccccc4cc3c21 CHEMBL231037 IC50 58.0 nM
CC(=O)c1ccc(Nc2nccc(-c3ccc(S(=O)(=O)N4CCNCC4)cc3)n2)cc1 CHEMBL424069 IC50 59.0 nM
O=S(=O)(c1ccc(-c2ccnc(Nc3ccc(-c4ccc5ncsc5c4)cc3)n2)cc1)N1CCNCC1 CHEMBL129981 IC50 60.0 nM
N#Cc1c(C(N)Cc2ccccc2)cc(-c2ccccc2O)nc1N CHEMBL182282 IC50 60.0 nM
CCC(N)(CC)CCc1ccc(-c2ccnc(Nc3ccc(C(=O)N4CCC(N5CCCC5)CC4)cc3)n2)s1 CHEMBL382945 IC50 60.0 nM
CNc1nc2sc(-c3ccc(CNC(C)=O)cc3)nc2c2c1ncn2C CHEMBL1642548 IC50 60.0 nM
CSCCCNc1ccc2ncc(-c3ccc(C(=O)NC[C@@H]4C[C@@H](F)CN4)c(F)c3)n2n1 CHEMBL1807621 IC50 61.0 nM
NC(=O)Nc1cc(-c2ccsc2)sc1C(N)=O CHEMBL1831078 IC50 63.0 nM
Cc1cc2c(-c3ccc(NS(C)(=O)=O)cc3)ccnc2[nH]1 CHEMBL485145 pIC50 63.1 nM
CS(=O)(=O)CCc1c[nH]c2c(C(N)=O)cc(-c3ccccc3)cc12 CHEMBL4549539 pIC50 63.1 nM
O=S(=O)(c1ccc(-c2ccnc(Nc3ccc4ncsc4c3)n2)cc1)N1CCNCC1 CHEMBL257805 IC50 64.0 nM
O=C(NC[C@@H]1CCCN1)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1F CHEMBL1807608 IC50 64.0 nM
CCCNc1ccc2ncc(-c3ccc(C(=O)NC[C@@H]4C[C@@H](F)CN4)c(F)c3)n2n1 CHEMBL1807615 IC50 64.0 nM
O=[N+]([O-])c1ccc(Nc2nccc(-c3ccc(S(=O)(=O)N4CCNCC4)cc3)n2)cc1 CHEMBL334758 IC50 66.0 nM
CNc1nc2[nH]c(-c3cccc(CNC(=O)C(C)(C)C)n3)cc2c2c1ncn2C CHEMBL1923977 IC50 66.0 nM
N#Cc1c(CCN)cc(-c2ccccc2O)nc1N CHEMBL184832 IC50 70.0 nM
CCN(C[C@H](NC(=O)c1ccc2[nH]c(-c3ccncc3)nc2c1)C(=O)O)c1ccccc1 CHEMBL514334 IC50 70.0 nM
CN(C)CCNc1cc(C(=O)Nc2ccc3c(c2)-c2c(c(C(N)=O)nn2-c2ccc(F)cc2)CC3)c(Cl)cn1 CHEMBL589339 IC50 70.0 nM
CO[C@H]1CN[C@H](CNC(=O)c2ccc(-c3cnc4ccc(NCC5CC5)nn34)cc2)C1 CHEMBL1669327 IC50 71.0 nM
O=C(NCCN1CCCC1)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1 CHEMBL1807603 IC50 71.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 71.0 nM
CCCc1cc(N2CCCNCC2)nc2sc(C(N)=O)c(N)c12 CHEMBL565347 IC50 72.0 nM
CC(CN(C)C)NC(=O)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1 CHEMBL1223207 IC50 73.0 nM
Cn1cnc2c(NCCNCCO)nc3sc(-c4ccc(F)cc4)nc3c21 CHEMBL450835 IC50 75.0 nM
CCNc1nc2sc(-c3cccc([C@H](C)NC(=O)c4cc(C)on4)c3)nc2c2c1ncn2C CHEMBL1642562 IC50 78.0 nM
NCc1ccc(-c2cnc3[nH]cc(-c4cccc(NC(=O)Nc5ccc(C(F)(F)F)cc5F)c4)c3c2)cc1 CHEMBL551024 IC50 79.0 nM
CCN(CC)CCNC(=O)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1 CHEMBL1223204 IC50 79.0 nM
O=S1(=O)CCC(NS(=O)(=O)c2ccc(-c3ccnc4[nH]ccc34)cc2)CC1 CHEMBL482746 pIC50 79.43 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc1)CCN2 CHEMBL260092 pKi 79.43 nM
Cc1cc2c(-c3ccc(S(=O)(=O)NC4CCS(=O)(=O)CC4)cn3)ccnc2[nH]1 CHEMBL2164418 pIC50 79.43 nM
NC(=O)c1cc(-c2ccccc2)cc2c(C3CCC(=O)C3)c[nH]c12 CHEMBL4472173 pIC50 79.43 nM
NC(=O)c1cc(-c2ccccc2)cc2c(C3CCCC(=O)C3)c[nH]c12 CHEMBL4539882 pIC50 79.43 nM
NC(=O)c1cc(-c2ccccc2)cc2c([C@@H]3C[C@H]4CC[C@@H](C3)S4(=O)=O)c[nH]c12 CHEMBL4438469 pIC50 79.43 nM
COc1ccc(CC(N)c2cc(-c3ccccc3O)nc(N)c2C#N)cc1 CHEMBL365281 IC50 80.0 nM
CC(C)Oc1cccc(O)c1-c1cc(C2CCCNC2)c(C#N)c(N)n1 CHEMBL180452 IC50 81.0 nM
CNc1nc2sc(S(C)(=O)=O)nc2c2c1ncn2C CHEMBL447603 IC50 81.0 nM
CNc1nc2[nH]c(-c3cccc(C4(NC(C)=O)CC4)n3)cc2c2c1ncn2C CHEMBL1923974 IC50 81.0 nM
N#Cc1cccc(Nc2nccc(-c3ccc(S(=O)(=O)N4CCNCC4)cc3)n2)c1 CHEMBL341432 IC50 83.0 nM
Cc1cnc2c(NCCO)nc3cc(-c4ccccc4)sc3n12 CHEMBL250337 IC50 85.0 nM
CNCC(=O)NCc1cccc(-c2cc3c(nc(NC)c4ncn(C)c43)[nH]2)n1 CHEMBL1923987 IC50 86.0 nM
O=C(Nc1cc(Cl)cc2c1[nH]c1cnccc12)c1cccnc1 CHEMBL79004 IC50 87.0 nM
O=C(c1ccc(Nc2nccc(-c3cc4ccccc4s3)n2)cc1Cl)N1CCC(N2CCCC2)CC1 CHEMBL199980 IC50 90.0 nM
NC(=O)c1nn(-c2ccc3c(c2)OCO3)c2c1CCc1ccc(NC(=O)c3cc(N4CCOCC4)ncc3Cl)cc1-2 CHEMBL591387 IC50 90.0 nM
O=C(Nc1cc(Cl)c2c(c1)[nH]c1cnccc12)c1cccnc1 CHEMBL4287264 IC50 90.0 nM
O=S(=O)(c1ccc(-c2ccnc(Nc3ccccc3)n2)cc1)N1CCNCC1 CHEMBL133928 IC50 91.0 nM
C[S+]([O-])c1ccc(Nc2nccc(-c3ccc(S(=O)(=O)N4CCNCC4)cc3)n2)cc1 CHEMBL134010 IC50 91.0 nM
Cc1cnc2c(NCCN(C)C)nc3cc(-c4ccccc4)sc3n12 CHEMBL249721 IC50 95.0 nM
COc1ccc(-c2cc3nc(NCCN)c4ncc(C)n4c3s2)cc1 CHEMBL249103 IC50 95.0 nM
CN(C[C@@H]1CCCN1)C(=O)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1 CHEMBL1669330 IC50 97.0 nM
CSCCNc1ccc2ncc(-c3ccc(C(=O)NC[C@@H]4C[C@@H](F)CN4)c(F)c3)n2n1 CHEMBL1807620 IC50 97.0 nM
Nc1ccccc1Oc1ccc(-c2ccnc(Nc3ccc(S(N)(=O)=O)cc3)n2)cc1 CHEMBL3942409 IC50 97.0 nM
CCCc1cc(N2CCC(NS(C)(=O)=O)CC2)nc2sc(C(N)=O)c(N)c12 CHEMBL570276 IC50 98.0 nM
CC1CN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc(F)cc3)CC4)c(Cl)cn2)CC(C)N1C CHEMBL590921 IC50 98.0 nM
COCCCc1ccc(-c2ccnc(Nc3ccc(C(=O)N4CCC(N5CCCC5)CC4)cc3)n2)s1 CHEMBL200462 IC50 100.0 nM
NC(=O)c1cc(-c2ccc(Cl)cc2)cc(-c2ccc(S(N)(=O)=O)cc2)c1N CHEMBL230488 pIC50 100.0 nM
NS(=O)(=O)c1ccc(-c2cc3ccncc3cc2OC2CCNCC2)cc1 CHEMBL519693 pIC50 100.0 nM
c1ccc(-c2cc3ccncc3cc2OC2CCNCC2)cc1 CHEMBL484968 pIC50 100.0 nM
O=C(NC[C@H]1CCCN1)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1 CHEMBL1223288 IC50 100.0 nM
CC(=O)N[C@@H](C)c1cccc(-c2nc3c(nc(N(C)C)c4ncn(C)c43)s2)c1 CHEMBL1642554 IC50 100.0 nM
NC(=O)Nc1cc(-c2cccc(O)c2)sc1C(N)=O CHEMBL1831079 IC50 100.0 nM
CS(=O)(=O)Nc1ccc(-c2nc(N)nc3[nH]cc(C#N)c23)cc1 CHEMBL4065551 Ki 100.0 nM
NC(=O)c1cc(-c2ccccc2)cc2c(C3CCS(=O)(=O)C3)c[nH]c12 CHEMBL4575249 pIC50 100.0 nM
CC(C)N1CCN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc(F)cc3)CC4)c(Cl)cn2)CC1 CHEMBL590961 IC50 107.0 nM
N#Cc1c(CC(N)c2ccccc2)cc(-c2ccccc2O)nc1N CHEMBL183009 IC50 110.0 nM
N#Cc1c(C2CCNCC2)cc(-c2c(O)cccc2OCc2ccccc2)nc1N CHEMBL425883 IC50 110.0 nM
CN1CCC[C@H]1CNC(=O)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1 CHEMBL1223355 IC50 110.0 nM
O=C(O)CN(C[C@@H]1C[C@@H](F)CN1)C(=O)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1 CHEMBL1669339 IC50 110.0 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 110.0 nM
O=S(=O)(c1ccc(-c2ccnc(Nc3ccc(F)c(F)c3)n2)cc1)N1CCNCC1 CHEMBL133471 IC50 117.0 nM
O=S(=O)(c1ccc(-c2ccnc(Nc3cc(F)cc(F)c3)n2)cc1)N1CCNCC1 CHEMBL2375544 pIC50 117.49 nM
CCOc1cccc(O)c1-c1cc(C2CCNCC2)c(C#N)c(N)n1 CHEMBL183341 IC50 120.0 nM
CCCc1cc(N2CCC(NC)CC2)nc2sc(C(N)=O)c(N)c12 CHEMBL570266 IC50 120.0 nM
CCCc1cc(N2CCNCC2)nc2sc(C(N)=O)c(N)c12 CHEMBL568922 IC50 120.0 nM
O=C(NC[C@@H]1C[C@@H](F)CN1)c1ccc(-c2cnc3ccc(NCCCF)nn23)cc1F CHEMBL1807622 IC50 120.0 nM
CN1CCN(c2cc(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc(F)cc3)CC4)ccn2)CC1 CHEMBL591764 IC50 125.0 nM
NCc1ccc(-c2cc3ccncc3cc2OC2CCNCC2)cc1 CHEMBL484967 pIC50 125.89 nM
CC(=O)CCc1c[nH]c2c(C(N)=O)cc(-c3ccccc3)cc12 CHEMBL4436032 pIC50 125.89 nM
CNc1nc2[nH]c(-c3cccc(N4CCN(C)CC4)n3)cc2c2c1ncn2C CHEMBL1923993 IC50 128.0 nM
O=C(Nc1ccc(-c2ccnc(Nc3ccc4ncsc4c3)n2)cc1)C1CCCN1 CHEMBL254556 pIC50 128.82 nM
Cc1cnc2c(NCCN)nc3cc(-c4ccccc4CO)sc3n12 CHEMBL400389 IC50 130.0 nM
CNc1nc2sc(N3CCCCCC3)nc2c2c1ncn2C CHEMBL522318 IC50 130.0 nM
O=S(=O)(NCCO)c1ccc(Nc2nccc(-c3ccsc3)n2)cc1 CHEMBL1085309 IC50 130.0 nM
CC(=O)N[C@@H](C)c1cccc(-c2nc3c(nc(NC(=O)N(C)C)c4ncn(C)c43)s2)c1 CHEMBL1642553 IC50 130.0 nM
Cc1ccc2nc(NCCN)c3ncc(C)n3c2c1 CHEMBL249697 Kd 130.0 nM
CNc1nc2[nH]c(-c3cccc(NC(C)=O)n3)cc2c2c1ncn2C CHEMBL1923990 IC50 130.0 nM
Cc1ccc2nc(NCCN)c3ncc(C)n3c2c1 CHEMBL4799297 Kd 130.0 nM
O=C1NCc2c1c1c3cc(O)ccc3[nH]c1c1[nH]c3ccccc3c21 CHEMBL4294912 IC50 139.2 nM
Cc1cnc2c(NCCN)nc3cc(-c4cccnc4)sc3n12 CHEMBL250107 IC50 140.0 nM
CCCc1cc(N2CCCNC(=O)C2)nc2sc(C(N)=O)c(N)c12 CHEMBL571910 IC50 140.0 nM
CCN1CCC[C@H]1CNC(=O)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1 CHEMBL1221431 IC50 140.0 nM
O=C(NCCN1CCCC1)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1F CHEMBL1807607 IC50 140.0 nM
O=C(NCCN1CCCC1)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)nc1 CHEMBL1807612 IC50 140.0 nM
O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nsnc1O CHEMBL4284710 IC50 143.0 nM
COc1cc(Nc2nccc(-c3ccc(S(=O)(=O)N4CCNCC4)cc3)n2)cc(OC)c1OC CHEMBL132942 IC50 145.0 nM
NC(=O)c1c[nH]c2ccc(-c3ccc(Nc4nccc(-c5ccc(S(=O)(=O)N6CCNCC6)cc5)n4)cc3)cc12 CHEMBL337236 IC50 146.0 nM
NC(=O)c1nn(-c2ccc(F)cc2)c2c1CCc1ccc(NC(=O)c3cc(N4CCOCC4)ncc3Cl)cc1-2 CHEMBL603405 IC50 146.0 nM
O=S(=O)(c1ccc(-c2ccnc(Nc3ccc(Cl)cc3)n2)cc1)N1CCNCC1 CHEMBL130866 IC50 148.0 nM
CC(N)c1cc(-c2ccccc2O)nc(N)c1C#N CHEMBL179997 IC50 150.0 nM
CC(=O)NC(C)(C)CCc1ccc(-c2ccnc(Nc3ccc(C(=O)N4CCC(N5CCCC5)CC4)cc3)n2)s1 CHEMBL372160 IC50 150.0 nM
CC(C)(N)C#Cc1ccc(-c2ccnc(Nc3ccc(C(=O)N4CCC(N5CCCC5)CC4)cc3)n2)s1 CHEMBL381041 IC50 150.0 nM
CCCc1cc(N2CCN(C(N)=O)CC2)nc2sc(C(N)=O)c(N)c12 CHEMBL571368 IC50 150.0 nM
NC(=O)Nc1ccc(Nc2nccc(-c3ccc(S(=O)(=O)N4CCNCC4)cc3)n2)cc1 CHEMBL411659 IC50 155.0 nM
NCCNNS(=O)(=O)c1ccc(-c2cc(-c3ccccc3)cc(C(N)=O)c2N)cc1 CHEMBL230047 pIC50 158.49 nM
CS(=O)(=O)c1ccc(-c2cc(C(N)=O)c(N)c(-c3ccc(S(N)(=O)=O)cc3)c2)cc1 CHEMBL230912 pIC50 158.49 nM
CS(=O)(=O)Nc1ccc(-c2ccnc3[nH]ccc23)cc1 CHEMBL453707 pIC50 158.49 nM
c1ccc(-c2cc3ccncc3cc2OCC2CCCNC2)cc1 CHEMBL484012 pIC50 158.49 nM
NS(=O)(=O)c1ccc(-c2cc3ccncc3cc2OCC2CCCNC2)cc1 CHEMBL482944 pIC50 158.49 nM
NC(=O)c1cc(-c2ccccc2)cc2c(C3CCCNC3)c[nH]c12 CHEMBL1761510 pIC50 158.49 nM
O=C1NCCc2[nH]c(-c3ccnc(C=Cc4ccccc4)c3)cc21 CHEMBL1997129 pKi 158.49 nM
NCCNS(=O)(=O)c1ccc(-c2cc(-c3ccccc3)cc(C(N)=O)c2N)cc1 CHEMBL2375430 pIC50 158.49 nM
NC(=O)c1cc(-c2ccccc2)cc2c(C3CCCS(=O)(=O)C3)c[nH]c12 CHEMBL4584067 pIC50 158.49 nM
CNc1nc2sc(C(=O)NC3CCCC3)nc2c2c1ncn2C CHEMBL492754 IC50 160.0 nM
O=C(c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1)N1CCC[C@@H]1CN1CCCC1 CHEMBL1223287 IC50 160.0 nM
CN1CCN(CCCCCOc2ccc(N3C(=O)/C(=C/c4ccc(Oc5ccc(C(N)=O)cc5)cc4)SC3=S)cc2)CC1 CHEMBL2070415 IC50 160.0 nM
CCn1nc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(C)CC4)c(C(F)(F)F)c3)ccc2C)c2c(N)ncnc21 CHEMBL3426225 IC50 164.0 nM
Cc1cnc2c(NCCN)nc3ccsc3n12 CHEMBL249900 IC50 170.0 nM
CN(C)CCCNS(=O)(=O)c1ccc(Nc2nccc(-c3ccsc3)n2)cc1 CHEMBL1085710 IC50 170.0 nM
Cn1cnc2c(N)nc3sc(-c4ccc(F)cc4)nc3c21 CHEMBL522331 IC50 180.0 nM
NS(=O)(=O)c1ccc(Nc2nccc(-c3ccsc3)n2)cc1 CHEMBL1084970 IC50 180.0 nM
CNc1nc2cc(-c3cccc(C(=O)O)c3)sc2n2c(C)cnc12 CHEMBL401301 IC50 190.0 nM
Cc1cnc2c(NCCN)nc3cc(-c4ccccn4)sc3n12 CHEMBL398513 IC50 190.0 nM
O=C(NC[C@@H]1CCCN1)c1ccc(-c2cnc3ccc(NCc4cccc(Cl)c4)nn23)cc1 CHEMBL1222992 IC50 190.0 nM
NC(=O)Nc1sc(C#Cc2csc(CO)c2)cc1C(N)=O CHEMBL365367 IC50 195.0 nM
NC(=O)c1cc(-c2ccc(F)cc2)cc(-c2ccc(S(N)(=O)=O)cc2)c1N CHEMBL230276 pIC50 199.53 nM
CN(C)CCNS(=O)(=O)c1ccc(-c2ccnc3[nH]ccc23)cc1 CHEMBL520954 pIC50 199.53 nM
CC1(C)CC(O)NC1c1c[nH]c2c(C(N)=O)cc(-c3ccccc3)cc12 CHEMBL4553495 pIC50 199.53 nM
CN(C)CCNC(=O)c1ccc(Nc2nccc(-c3cc4ccccc4s3)n2)cc1 CHEMBL200832 IC50 200.0 nM
O=C(NC[C@@H]1CCCN1)c1ccc(-c2cnc3ccc(NC4CC4)nn23)cc1 CHEMBL1222929 IC50 200.0 nM
CN(C)CCNC(=O)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1 CHEMBL1223203 IC50 200.0 nM
NC(=O)Nc1sc2c(c1C(N)=O)CCc1c-2cnn1Cc1ccc(F)cc1 CHEMBL1681967 IC50 200.0 nM
CN(C)CCNC(=O)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)nc1 CHEMBL1807611 IC50 200.0 nM
CNC(=O)Nc1cc(-c2ccccc2OC)sc1C(N)=O CHEMBL1831205 IC50 200.0 nM
CN1CCN(CCCOc2ccc(N3C(=O)S/C(=C\c4ccc(Oc5ccc(C#N)cc5)cc4)C3=O)cc2)CC1 CHEMBL4798160 IC50 200.0 nM
CNc1nc2sc(N3CCCCC3)nc2c2c1ncn2C CHEMBL492332 IC50 210.0 nM
CNc1ncccc1C(=O)Nc1ccc2c(c1)-c1c(c(C(N)=O)nn1-c1ccc3c(c1)OCO3)CC2 CHEMBL589540 IC50 210.0 nM
COc1ccc(Nc2nccc(-c3ccc(S(=O)(=O)N4CCNCC4)cc3)n2)cc1 CHEMBL338848 IC50 214.0 nM
O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(Cl)ccc1O CHEMBL536151 IC50 218.0 nM
CN1CCN(CCCCCOc2cccc(N3C(=O)S/C(=C\c4ccc(Oc5ccc([N+](=O)[O-])cc5)cc4)C3=O)c2)CC1 CHEMBL4750150 pIC50 218.78 nM
CNc1nc2cc(-c3nccs3)sc2c2c1ncn2C CHEMBL2375678 pIC50 229.09 nM
CN1CCCC(c2cc(-c3ccccc3O)nc(N)c2C#N)C1 CHEMBL185153 IC50 230.0 nM
N#Cc1c(N)nc(-c2ccccc2O)c(F)c1C1CCCNC1 CHEMBL182315 IC50 230.0 nM
Cc1cnc2c(NCCNC=O)nc3cc(-c4ccccc4)sc3n12 CHEMBL250131 IC50 230.0 nM
Cc1cnc2c(NCCN)nc3cc(-c4nccs4)sc3n12 CHEMBL398511 IC50 230.0 nM
O=S(=O)(Nc1ccc(-c2ccnc(Nc3ccc4ncsc4c3)n2)cc1)c1ccc2nonc2c1 CHEMBL402041 IC50 230.0 nM
CN(C)CCNS(=O)(=O)c1ccc(Nc2nccc(-c3ccsc3)n2)cc1 CHEMBL1085880 IC50 230.0 nM
CN1CCN(CCCCOc2ccc(N3C(=O)/C(=C/c4ccc(Oc5ccc(C(N)=O)cc5)cc4)SC3=S)cc2)CC1 CHEMBL2070414 IC50 230.0 nM
CC(C)C(N)c1cc(-c2ccccc2O)nc(N)c1C#N CHEMBL184831 IC50 240.0 nM
CCCc1cc(N2CCC(O)C(C)(C)C2)nc2sc(C(N)=O)c(N)c12 CHEMBL569550 IC50 240.0 nM
Cc1ccc2nc(NCCN)c3ncc(C)n3c2c1 CHEMBL471496 IC50 240.0 nM
O=C1S/C(=C\c2ccc(Oc3ccc(F)cc3)cc2)C(=O)N1c1ccc(OCCCCCN2CCN(CC3CC3)CC2)cc1 CHEMBL4294525 pIC50 240.44 nM
O=S(=O)(c1ccc(-c2ccnc(Nc3ccc4ncsc4c3)n2)cc1)N1CCSCC1 CHEMBL257402 IC50 250.0 nM
O=C1S/C(=C\c2ccc(N3CCOCC3)c(Cl)c2)C(=O)N1c1ccc(OCCCN2CCN(CC3CC3)CC2)cc1 CHEMBL4288137 pIC50 250.61 nM
NC(=O)c1cc(-c2ccccc2)cc(-c2ccc(S(=O)(=O)NNCCN3CCCC3)cc2)c1N CHEMBL231129 pIC50 251.19 nM
COCCCNNS(=O)(=O)c1ccc(-c2cc(-c3ccccc3)cc(C(N)=O)c2N)cc1 CHEMBL426532 pIC50 251.19 nM
NC(=O)c1cc(-c2ccncc2)cc(-c2ccc(S(N)(=O)=O)cc2)c1N CHEMBL397009 pIC50 251.19 nM
NC(=O)c1cc(-c2ccccc2)cc(-c2ccc(S(N)(=O)=O)cc2)c1N CHEMBL397008 pIC50 251.19 nM
O=S(=O)(c1ccc(-c2ccnc3[nH]ccc23)cc1)N1CCCC1 CHEMBL520655 pIC50 251.19 nM
NCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL590109 pKi 251.19 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 251.19 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc6[nH]ccc6c5)c4c3)cc2)CC1 CHEMBL2436978 IC50 257.0 nM
CCNc1nc2cc(-c3ccccc3)sc2n2c(C)cnc12 CHEMBL249720 IC50 260.0 nM
NC(=O)Nc1sc(C#CC2CC2)cc1C(N)=O CHEMBL194110 pIC50 263.03 nM
Cc1ccc(Nc2nccc(-c3ccc(S(=O)(=O)N4CCNCC4)cc3)n2)cc1 CHEMBL130511 IC50 269.0 nM
N#Cc1c(C2CCNCC2)cc(-c2c(O)cccc2O)nc1N CHEMBL183187 IC50 270.0 nM
Cc1cnc2c(NCCN)nc3cc(-c4ccncc4)sc3n12 CHEMBL398514 IC50 270.0 nM
NCCC(=O)Nc1ccc(-c2ccnc(Nc3ccc4ncsc4c3)n2)cc1 CHEMBL254793 IC50 270.0 nM
CC(C)Nc1ccc2ncc(-c3ccc(C(=O)NC[C@@H]4CCCN4)cc3)n2n1 CHEMBL1222928 IC50 270.0 nM
CC(=O)c1cc(C#Cc2cccc(NC(=O)C3CC3)c2)sc1NC(N)=O CHEMBL1831206 IC50 273.0 nM
CC(=O)NCc1cc(-c2cc3nc(NC4CC4)c4ncn(C)c4n3n2)ccc1F CHEMBL523189 IC50 279.0 nM
COc1ccccc1-c1cc2nc(NCCN)c3ncc(C)n3c2s1 CHEMBL248899 IC50 280.0 nM
CCCc1cc(N2CCC(O)CC2)nc2sc(C(N)=O)c(N)c12 CHEMBL576887 IC50 280.0 nM
COC(=O)CC(=O)Nc1ccc2c(c1)CCc1cnc(Nc3ccc(S(N)(=O)=O)cc3)nc1-2 CHEMBL1083483 IC50 280.0 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5cnc6[nH]ccc6c5)c4c3)cc2)CC1 CHEMBL2436977 IC50 288.0 nM
CNc1nc2cc(-c3cccc(C(N)=O)c3)sc2n2c(C)cnc12 CHEMBL249682 IC50 290.0 nM
CC(=O)NCCNc1nc2cc(-c3ccccc3)sc2n2c(C)cnc12 CHEMBL250335 IC50 290.0 nM
CN1CCN(c2ccc(Cl)c(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc5c(c3)OCO5)CC4)n2)CC1 CHEMBL590598 IC50 297.0 nM
CC(C)(C)c1nc2c3ccc(F)cc3c3c(=O)[nH]ccc3c2[nH]1 CHEMBL21156 IC50 300.0 nM
N#Cc1c(C2CCNCC2)cc(-c2ccccc2O)nc1N CHEMBL181358 IC50 300.0 nM
CNc1nc2sc(NCCO)nc2c2c1ncn2C CHEMBL506895 IC50 300.0 nM
CN(C)CCNC(=O)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1F CHEMBL1807606 IC50 300.0 nM
COc1cccc(-c2cc(NC(N)=O)c(C(N)=O)s2)c1 CHEMBL1831194 IC50 300.0 nM
CNC(=O)Nc1cc(-c2cccc(OC)c2)sc1C(N)=O CHEMBL1831207 IC50 300.0 nM
CS(=O)(=O)c1ccc(-c2nc(N)nc3[nH]cc(C#N)c23)cc1 CHEMBL4061406 Ki 300.0 nM
NC(=O)Nc1sc(C#Cc2cccc(O)c2)cc1C(N)=O CHEMBL197405 IC50 303.0 nM
CCCCc1ccc(Nc2nccc(-c3ccc(S(=O)(=O)N4CCNCC4)cc3)n2)cc1 CHEMBL334506 IC50 309.0 nM
NS(=O)(=O)c1ccc(Nc2ncc3c(n2)-c2ccc(NC(=O)Cc4ccsc4)cc2CC3)cc1 CHEMBL1084628 IC50 310.0 nM
CC(N)CNC(=O)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1 CHEMBL1223206 IC50 310.0 nM
N#Cc1c(N)nc(-c2cc(O)ccc2O)nc1C1CCCNC1 CHEMBL473619 IC50 316.0 nM
NC(=O)c1cc(-c2ccccc2)cc(-c2ccc(S(=O)(=O)NNC3CC3)cc2)c1N CHEMBL388646 pIC50 316.23 nM
NC(=O)c1cc(-c2ccccc2)cc(-c2ccc(S(=O)(=O)NNCCCN3CCOCC3)cc2)c1N CHEMBL231614 pIC50 316.23 nM
CN(C)CCCNNS(=O)(=O)c1ccc(-c2cc(-c3ccccc3)cc(C(N)=O)c2N)cc1 CHEMBL231512 pIC50 316.23 nM
NS(=O)(=O)c1ccc(-c2ccnc3[nH]ccc23)cc1 CHEMBL519028 pIC50 316.23 nM
Cc1cc2c(-c3ccc(N(C)S(C)(=O)=O)cc3)ccnc2[nH]1 CHEMBL484966 pIC50 316.23 nM
NC(=O)c1cc(-c2ccc(Cl)cc2)cc2cc[nH]c12 CHEMBL1761504 pIC50 316.23 nM
N#Cc1ncc2nc1OCCCCCOc1cc(OCCCO)c(Cl)cc1NC(=O)N2 CHEMBL373598 pKi 316.23 nM
CN(c1ccc(-c2ccnc3[nH]ccc23)cc1)S(C)(=O)=O CHEMBL2375545 pIC50 316.23 nM
O=C(NC[C@@H]1CCCN1)c1ccc(-c2cnc3ccc(NCc4ccc(Cl)c(Cl)c4)nn23)cc1 CHEMBL1222565 IC50 320.0 nM
CS(=O)(=O)Nc1ccc(Nc2nccc(-c3ccc(Oc4ccccc4[N+](=O)[O-])cc3)n2)cc1 CHEMBL3956314 IC50 320.0 nM
CNc1nc2ccc(C)cc2n2c(Br)cnc12 CHEMBL3787023 IC50 324.0 nM
CC(=O)Nc1nc(-c2ccccc2O)cc(C2CCCNC2)c1C#N CHEMBL182312 IC50 330.0 nM
O=C(NC[C@@H]1CCCN1)c1ccc(-c2cnc3ccc(NCc4ccccc4)nn23)cc1 CHEMBL1222991 IC50 330.0 nM
CN(C)CCN(C)C(=O)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1 CHEMBL1223205 IC50 330.0 nM
CNc1nc2[nH]c(-c3cc(CNC(C)=O)ccn3)cc2c2c1ncn2C CHEMBL1923994 IC50 330.0 nM
CC(=O)Nc1ccc(Nc2nccc(-c3ccc(S(=O)(=O)N4CCNCC4)cc3)n2)cc1 CHEMBL336594 IC50 331.0 nM
NC(=O)Nc1sc(C#Cc2cccc(F)c2)cc1C(N)=O CHEMBL196783 IC50 331.0 nM
CC(=O)c1cc(C#Cc2cccc(NC(=O)c3cccc(F)c3)c2)sc1NC(N)=O CHEMBL1831208 IC50 331.0 nM
N#Cc1cc(C#Cc2cc(C(N)=O)c(NC(N)=O)s2)cs1 CHEMBL197414 IC50 333.0 nM
CN1CCN(c2ccc(Cl)c(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc(F)cc3)CC4)n2)CC1 CHEMBL592892 IC50 348.0 nM
CN1CCN(CCCOc2ccc(N3C(=O)/C(=C/c4ccc(Oc5ccc(C(N)=O)cc5)cc4)SC3=S)cc2)CC1 CHEMBL2070413 IC50 350.0 nM
Cc1cnc2c(NCC(N)=O)nc3cc(-c4ccccc4)sc3n12 CHEMBL249929 IC50 360.0 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 Kd 360.0 nM
Cc1cnc2c(N)nc3cc(-c4ccccc4)sc3n12 CHEMBL399383 IC50 370.0 nM
CC1=CNC2C(N)=Nc3cc(-c4ccccc4)sc3N12 CHEMBL1831209 IC50 370.0 nM
O=C(Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1)[C@H]1CCCN1 CHEMBL2208034 IC50 375.4 nM
N#Cc1ncc2nc1OCCCCCOc1cc(CCCO)c(Cl)cc1NC(=O)N2 CHEMBL223367 Ki 380.0 nM
O=S(=O)(c1ccc(-c2ccnc(Nc3ccc4ncsc4c3)n2)cc1)N1CCOCC1 CHEMBL257189 IC50 380.0 nM
O=C(NC[C@@H]1CCCN1)c1ccc(-c2cnc3ccc(NCCCn4ccnc4)nn23)cc1 CHEMBL1223063 IC50 380.0 nM
CS(=O)(=O)c1ccc(-c2cc(C(N)=O)c(N)c(-c3ccc(S(=O)(=O)N4CCCC4)cc3)c2)cc1 CHEMBL230913 pIC50 398.11 nM
NS(=O)(=O)Cc1ccc(-c2cc3ccncc3cc2OC2CCNCC2)cc1 CHEMBL482769 pIC50 398.11 nM
Brc1cc2ccncc2cc1OC1CCNCC1 CHEMBL485008 pIC50 398.11 nM
NC(=O)c1cc(-c2ccccc2)cc2c(C3CCN(S(=O)(=O)c4ccc(Cl)cc4)CC3)c[nH]c12 CHEMBL1761515 pIC50 398.11 nM
CN(C)CC(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1965631 pKi 398.11 nM
O=C(Nc1ccc(-c2ccnc(Nc3ccc4ncsc4c3)n2)cc1)C1CCNCC1 CHEMBL403615 pIC50 398.11 nM
O=C(NCCN1CCCC1)c1ccc(Nc2nccc(-c3cc4ccccc4s3)n2)cc1 CHEMBL371967 IC50 400.0 nM
Cc1cc(-c2c3ccccc3c(Br)c3sc(C)c(C)c23)cc(C)c1O[C@H](Cc1ccccc1)C(=O)O CHEMBL184041 IC50 400.0 nM
CNS(=O)(=O)c1ccc(-c2nc(N)nc3[nH]cc(C#N)c23)cc1 CHEMBL4074174 Ki 400.0 nM
CN1CCN(c2ccc(-c3ccnc(Nc4ccc5ncsc5c4)n3)cc2)CC1 CHEMBL402628 pIC50 407.38 nM
CN(C)S(=O)(=O)c1ccc(-c2ccnc(Nc3ccc4ncsc4c3)n2)cc1 CHEMBL256524 IC50 410.0 nM
O=C(NC[C@@H]1CCCN1)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cc1Cl CHEMBL1807610 IC50 410.0 nM
NC(=O)Nc1sc(C#Cc2ccsc2)cc1C(N)=O CHEMBL194941 pIC50 416.87 nM
COc1ccc2c(c1)CCc1cnc(Nc3ccc(S(N)(=O)=O)cc3)nc1-2 CHEMBL1082512 IC50 420.0 nM
CC(=O)c1cc(C#Cc2cccc(NC(=O)c3ccsc3)c2)sc1NC(N)=O CHEMBL1831210 IC50 420.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 430.0 nM
CN1CCN(CCCCCOc2ccc(N3C(=O)S/C(=C\c4ccc(Oc5ccc(Br)cc5)cc4)C3=O)cc2)CC1 CHEMBL4753837 IC50 430.0 nM
CNc1nc2[nH]c(-c3cccc(N(C)CCOC)n3)cc2c2c1ncn2C CHEMBL1923992 IC50 438.0 nM
O=S(=O)(c1ccccc1)c1ccc(-c2ccnc(Nc3ccc4ncsc4c3)n2)cc1 CHEMBL256148 IC50 440.0 nM
Cc1cnc2c(NCCN)nc3cc(-c4ncc[nH]4)sc3n12 CHEMBL2375675 pIC50 446.68 nM
Cc1cnc2c(NCCN)nc3cc(C4=NCN=C4)sc3n12 CHEMBL398512 IC50 450.0 nM
CS(=O)(=O)Nc1cccc(C#Cc2cc(C(N)=O)c(NC(N)=O)s2)c1 CHEMBL193551 IC50 454.0 nM
CCC(O)c1cc(C#Cc2cc(C(N)=O)c(NC(N)=O)s2)cs1 CHEMBL195780 IC50 465.0 nM
CC(N)Cc1cc(-c2ccccc2O)nc(N)c1C#N CHEMBL360196 IC50 470.0 nM
CNc1ccc(Cl)c(C(=O)Nc2ccc3c(c2)-c2c(c(C(N)=O)nn2-c2ccc4c(c2)OCO4)CC3)n1 CHEMBL591246 IC50 477.0 nM
CCCCC(N)c1cc(-c2ccccc2O)nc(N)c1C#N CHEMBL361652 IC50 480.0 nM
CNc1nc2cc(C)sc2n2c(C)cnc12 CHEMBL249073 IC50 490.0 nM
N#Cc1c(-c2ccc(NC(=O)CCCC(=O)[O-])cc2)cc(-c2ccccc2O)nc1N CHEMBL170406 IC50 500.0 nM
N#Cc1c(-c2ccccc2C(=O)NCCN2CCCCC2)cc(-c2ccccc2O)nc1N CHEMBL426403 IC50 500.0 nM
CCCc1cc(N2CC[C@@H](N)C2)nc2sc(C(N)=O)c(N)c12 CHEMBL579008 IC50 500.0 nM
NC(=O)Nc1sc2c(c1C(N)=O)CCc1nn(C3CCCN(Cc4ccc(Cl)cc4F)C3)cc1-2 CHEMBL1681985 IC50 500.0 nM
NC(=O)Nc1sc2c(c1C(N)=O)CCc1nn(C3CCCN(Cc4ccc(N)cc4F)C3)cc1-2 CHEMBL1681988 IC50 500.0 nM
CS(=O)(=O)Nc1ccc(-c2cc(C(N)=O)c3[nH]ccc3c2)cc1 CHEMBL1761501 pIC50 501.19 nM
NC(=O)c1cc(-c2cc3ccccc3o2)cc2cc[nH]c12 CHEMBL1761509 pIC50 501.19 nM
NC(=O)c1cc(-c2ccccc2)cc2c(C3CCNCC3)c[nH]c12 CHEMBL1761511 pIC50 501.19 nM
N#Cc1ncc2nc1OCCCCCOc1cc(OCCO)c(Cl)cc1NC(=O)N2 CHEMBL413779 pKi 501.19 nM
CN1C(=O)CCC1c1c[nH]c2c(C(N)=O)cc(-c3ccccc3)cc12 CHEMBL4553909 pIC50 501.19 nM
NC(=O)c1cc(-c2ccccc2)cc2c(C3CCC(=O)CC3)c[nH]c12 CHEMBL4448678 pIC50 501.19 nM
NS(=O)(=O)c1ccc(Nc2ncc3c(n2)-c2ccc(NC(=O)Cc4cccs4)cc2CC3)cc1 CHEMBL1084361 IC50 510.0 nM
CN(C)CCNS(=O)(=O)c1ccc(Nc2ncc3c(n2)-c2ccsc2CC3)cc1 CHEMBL1085881 IC50 510.0 nM
O=S(=O)(c1ccc(-c2ccnc(Nc3ccc(C(F)(F)F)cc3)n2)cc1)N1CCNCC1 CHEMBL133941 pIC50 512.86 nM
CNc1nc2ccsc2n2c(C)cnc12 CHEMBL250539 IC50 520.0 nM
CNc1nc2c(nc(-c3ccccc3)n2C)c2c1ncn2C CHEMBL522011 IC50 520.0 nM
CCCc1cc(N2CCN(C)CC2)nc2sc(C(N)=O)c(N)c12 CHEMBL569580 IC50 520.0 nM
N#Cc1c(C2CCCCN2)cc(-c2ccccc2O)nc1N CHEMBL362249 IC50 530.0 nM
O=C(NC[C@@H]1CCCN1)c1ccc(-c2cnc3ccc(N[C@H]4CC[C@H](O)CC4)nn23)cc1 CHEMBL1223136 IC50 530.0 nM
O=S(=O)(c1ccc(-c2ccnc(Nc3ccc4ncsc4c3)n2)cc1)N1CCCC1 CHEMBL256523 IC50 540.0 nM
O=C(NC[C@@H]1CCCN1)c1ccc(-c2cnc3ccc(NCCCO)nn23)cc1 CHEMBL1223060 IC50 550.0 nM
NC(=O)Nc1sc(C#Cc2cccc(NC(=O)c3cccnc3)c2)cc1C(N)=O CHEMBL193601 IC50 557.0 nM
COc1ccc(-c2cc(C3CCCNC3)c(C#N)c(N)n2)c(O)c1 CHEMBL361171 IC50 560.0 nM
CC(C)C(O)c1cc(C(=O)Nc2cccc(C#Cc3cc(C(N)=O)c(NC(N)=O)s3)c2)cs1 CHEMBL1831195 IC50 560.0 nM
CC(C)C(O)c1cc(C#Cc2cc(C(N)=O)c(NC(N)=O)s2)cs1 CHEMBL197358 IC50 563.0 nM
CCCc1cc(N2CCCC(O)C2)nc2sc(C(N)=O)c(N)c12 CHEMBL576989 IC50 570.0 nM
CNc1nc2ccc(C)cc2n2ccnc12 CHEMBL3787275 IC50 579.0 nM
NC(=O)c1nn(-c2ccc(F)cc2)c2c1CCc1ccc(NC(=O)c3ccnc(N4CCOCC4)c3)cc1-2 CHEMBL592002 IC50 589.0 nM
CCNC(=O)C(N)Cc1cccc(-c2cc3nc(NC)c4ncc(C)n4c3s2)c1 CHEMBL251724 IC50 590.0 nM
CCCc1cc(N2CC[C@H](N)C2)nc2sc(C(N)=O)c(N)c12 CHEMBL579389 IC50 590.0 nM
O=C(NCCN1CCCC1)c1ccc(-c2cnc3ccc(NCc4ccc(Cl)c(Cl)c4)nn23)cc1 CHEMBL1222474 IC50 590.0 nM
N#Cc1c(-c2ccc(C(=O)NCCN3CCCCC3)cc2)cc(-c2ccccc2O)nc1N CHEMBL170463 IC50 600.0 nM
N#Cc1c(-c2cccc(NC(=O)CCN3CCCCC3)c2)cc(-c2ccccc2O)nc1N CHEMBL173484 IC50 600.0 nM
N#Cc1c(-c2cccc(NC(=O)CC(N)C(=O)O)c2)cc(-c2ccccc2O)nc1N CHEMBL352549 IC50 600.0 nM
N#Cc1c(-c2cccc(NC(=O)C(N)CC(=O)O)c2)cc(-c2ccccc2O)nc1N CHEMBL170563 IC50 600.0 nM
O=C(O)c1ccc(Nc2nccc(-c3cc4ccccc4s3)n2)cc1 CHEMBL200946 IC50 600.0 nM
NCCNC(=O)c1ccc(Nc2nccc(-c3cc4ccccc4s3)n2)cc1 CHEMBL370166 IC50 600.0 nM
O=S(=O)(c1ccc(-c2ccnc(Nc3ccc4ncsc4c3)n2)cc1)N1CCCCC1 CHEMBL401919 IC50 600.0 nM
CN1CCN(CCCOc2ccc(N3C(=O)/C(=C/c4ccc(Oc5ccc(S(N)(=O)=O)cc5)cc4)SC3=S)cc2)CC1 CHEMBL3763391 IC50 600.0 nM
CN1CCN(CCCCCOc2ccc(N3C(=O)S/C(=C\c4ccc(Oc5ccc(F)cc5)cc4)C3=O)cc2)CC1 CHEMBL4751303 IC50 600.0 nM
Nc1nc(-c2ccc(S(N)(=O)=O)cc2)c2cc[nH]c2n1 CHEMBL4096206 Ki 610.0 nM
NC(=O)c1nn(-c2ccc3c(c2)OCO3)c2c1CCc1ccc(NC(=O)c3nc(N4CCOCC4)ccc3Cl)cc1-2 CHEMBL590713 IC50 612.0 nM
NC(=O)Nc1sc(C#Cc2ccccc2F)cc1C(N)=O CHEMBL193939 IC50 620.0 nM
CN(C)CCCNS(=O)(=O)c1ccc(Nc2ncc3c(n2)-c2ccsc2CC3)cc1 CHEMBL1085308 IC50 620.0 nM
CC(=O)c1cc(C#Cc2cccc(NC(=O)c3ccccc3F)c2)sc1NC(N)=O CHEMBL1831211 IC50 620.0 nM
CCCc1cc(N2CCCCC(N)C2)nc2sc(C(N)=O)c(N)c12 CHEMBL565348 IC50 630.0 nM
NC(=O)c1cc(-c2ccc(F)cc2)cc(-c2ccc(S(=O)(=O)N3CCCC3)cc2)c1N CHEMBL230055 pIC50 630.96 nM
NC(=O)c1ccc(-c2ccnc3[nH]ccc23)cc1 CHEMBL504261 pIC50 630.96 nM
c1ccc(-c2cc3ccncc3cc2OC2CCCNC2)cc1 CHEMBL507333 pIC50 630.96 nM
NS(=O)(=O)c1ccc(-c2cc3ccncc3cc2OCC2CCNCC2)cc1 CHEMBL521130 pIC50 630.96 nM
CN1CCN(CCCOc2ccc(N3C(=O)/C(=C/c4ccc(Oc5ccc(C#N)cc5)cc4)SC3=S)cc2)CC1 CHEMBL3764354 IC50 640.0 nM
NC(=O)c1ccc(-c2cc(C(N)=O)c(N)c(-c3ccc(S(N)(=O)=O)cc3)c2)cc1 CHEMBL514582 IC50 650.0 nM
NC(=O)c1nn(-c2ccc(S(N)(=O)=O)cc2)c2c1CCc1[nH]ncc1-2 CHEMBL361862 IC50 670.0 nM
CN1CCN(CCCOc2ccc(N3C(=O)S/C(=C\c4ccc(Oc5ccc(F)cc5)cc4)C3=O)cc2)CC1 CHEMBL4792120 IC50 670.0 nM
CCCc1cc(N2CCC(N(C)C)CC2)nc2sc(C(N)=O)c(N)c12 CHEMBL570048 IC50 680.0 nM
CCCc1cc(N2CCC(OC)CC2)nc2sc(C(N)=O)c(N)c12 CHEMBL572003 IC50 680.0 nM
Cc1cc(N2CCNCC2)nc2sc(C(N)=O)c(N)c12 CHEMBL569813 IC50 680.0 nM
O=C(NCCN1CCCC1)c1ccc(-c2cnc3ccc(NCC4CC4)nn23)cn1 CHEMBL1807613 IC50 680.0 nM
N#Cc1c(-c2ccc(C(=O)[O-])cc2)cc(-c2ccccc2O)nc1N CHEMBL354947 IC50 700.0 nM
N#Cc1c(-c2ccccc2C(=O)[O-])cc(-c2ccccc2O)nc1N CHEMBL424766 IC50 700.0 nM
c1cn(-c2ccc(-c3ccnc(Nc4ccc5ncsc5c4)n3)cc2)cn1 CHEMBL428424 IC50 700.0 nM
CN1CCN(CCCCCOc2ccc(N3C(=O)S/C(=C\c4ccc(Oc5ccc(Cl)cc5)cc4)C3=O)cc2)CC1 CHEMBL4764685 IC50 700.0 nM
COc1ccc(Oc2ccc(/C=C3\SC(=O)N(c4ccc(OCCCCCN5CCN(C)CC5)cc4)C3=O)cc2)cc1 CHEMBL4748753 IC50 700.0 nM
NC(=O)Nc1sc(C#Cc2cccc(NC(=O)c3ccccc3)c2)cc1C(N)=O CHEMBL196653 IC50 704.0 nM
NC(=O)Nc1sc(C#Cc2cccc(N)c2)cc1C(N)=O CHEMBL381193 IC50 709.0 nM
NC(=O)Nc1sc(C#Cc2cccc(NC(=O)c3cccc(N)c3)c2)cc1C(N)=O CHEMBL1831196 IC50 710.0 nM
Cc1ccccc1C#Cc1cc(C(N)=O)c(NC(N)=O)s1 CHEMBL427363 IC50 716.0 nM
N#Cc1c(C(N)CCc2ccccc2)cc(-c2ccccc2O)nc1N CHEMBL182012 IC50 730.0 nM
Cc1cc(N2CCC(O)CC2)nc2sc(C(N)=O)c(N)c12 CHEMBL570923 IC50 750.0 nM
CNc1nc2ccc(C)cc2n2c(C)cnc12 CHEMBL3786867 IC50 773.0 nM
NS(=O)(=O)c1ccc(Nc2ncc3c(n2)-c2ccsc2CC3)cc1 CHEMBL1085654 IC50 790.0 nM
CN1CCN(CCCOc2ccc(N3C(=O)/C(=C/c4ccc(Oc5ccc(F)cc5)cc4)SC3=S)cc2)CC1 CHEMBL3765499 IC50 790.0 nM
CN1CCN(CCCOc2ccc(N3C(=O)/C(=C/c4ccc(Oc5ccc([N+](=O)[O-])cc5)cc4)SC3=S)cc2)CC1 CHEMBL3765155 IC50 790.0 nM
NCc1cccc(-c2cc3ccncc3cc2OC2CCNCC2)c1 CHEMBL482770 pIC50 794.33 nM
NS(=O)(=O)c1ccc(-c2cc3ccncc3cc2OC2CCCNC2)cc1 CHEMBL520316 pIC50 794.33 nM
NC(=O)c1cc(-c2cccc(Cl)c2)cc2cc[nH]c12 CHEMBL1761503 pIC50 794.33 nM
Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1990583 pKi 794.33 nM
Cc1cc(C)cc(NC(=O)Nc2ccc3c(c2)CCc2sc4ncnc(N)c4c2-3)c1 CHEMBL1964687 pKi 794.33 nM
Cc1cc2c(-c3ncc(S(=O)(=O)NC4CCS(=O)(=O)CC4)cn3)ccnc2[nH]1 CHEMBL2164419 pIC50 794.33 nM
CN(C)c1ccc(-c2cc(-c3ccccc3O)nc(N)c2C#N)cc1NC(=O)CCN1CCCCC1 CHEMBL535135 IC50 800.0 nM
CC(C)(C)CC(=O)Nc1ccc2c(c1)CCc1cnc(Nc3ccc(S(N)(=O)=O)cc3)nc1-2 CHEMBL1086087 IC50 820.0 nM
CN1CCN(CCCOc2ccc(N3C(=O)/C(=C/c4ccc(Oc5ccc(Cl)cc5)cc4)SC3=S)cc2)CC1 CHEMBL3764369 IC50 820.0 nM
CN1CCN(CCCOc2ccc(N3C(=O)/C(=C/c4ccc(Oc5ccc(NS(C)(=O)=O)cc5)cc4)SC3=S)cc2)CC1 CHEMBL3765759 IC50 820.0 nM
COc1ccc(Oc2ccc(/C=C3\SC(=S)N(c4ccc(OCCCN5CCN(C)CC5)cc4)C3=O)cc2)cc1 CHEMBL3765189 IC50 840.0 nM
CC(=O)Nc1ccc(Oc2ccc(/C=C3\SC(=S)N(c4ccc(OCCCN5CCN(C)CC5)cc4)C3=O)cc2)cc1 CHEMBL3763983 IC50 840.0 nM
CN1CCN(CCCCCOc2cccc(N3C(=O)S/C(=C\c4ccc(Oc5ccc(C#N)cc5)cc4)C3=O)c2)CC1 CHEMBL4790170 IC50 840.0 nM
CN1CCN(CCCOc2ccc(N3C(=O)/C(=C/c4ccc(Oc5ccc(N)cc5)cc4)SC3=S)cc2)CC1 CHEMBL3763572 IC50 850.0 nM
Cc1ccc(Oc2ccc(/C=C3\SC(=O)N(c4ccc(OCCCCCN5CCN(C)CC5)cc4)C3=O)cc2)cc1 CHEMBL4752782 IC50 870.0 nM
N#Cc1c(-c2cccc(NC(=O)C(O)CCC(=O)[O-])c2)cc(-c2ccccc2O)nc1N CHEMBL434691 IC50 900.0 nM
O=C(c1ccc(Nc2nccc(-c3cc4ccccc4s3)n2)cc1)N1CCCC1 CHEMBL382752 IC50 900.0 nM
NC(=O)Nc1sc2c(c1C(N)=O)CCc1nn(Cc3ccc(F)cc3)cc1-2 CHEMBL1681968 IC50 900.0 nM
NC(=O)Nc1sc2c(c1C(N)=O)CCc1nn(C3CCCN(Cc4ccc(O)cc4F)C3)cc1-2 CHEMBL1681989 IC50 900.0 nM
CN1CCN(CCCOc2ccc(N3C(=O)/C(=C/c4ccc(Oc5ccc(S(C)(=O)=O)cc5)cc4)SC3=S)cc2)CC1 CHEMBL3764955 IC50 900.0 nM
O=C1S/C(=C\c2ccc(N3CCOCC3)c(Cl)c2)C(=O)N1c1ccc(OCCCCCN2CCN(CC3CC3)CC2)cc1 CHEMBL4277493 IC50 900.0 nM
CNc1nc2c(nc(NC)c3ncn(C)c32)s1 CHEMBL454470 IC50 920.0 nM
NS(=O)(=O)N1CCC(Nc2nccc(-c3ccc(S(=O)(=O)N4CCOCC4)cc3)n2)CC1 CHEMBL1773329 IC50 920.0 nM
CC(C)=CC(=O)O[C@@H]1CC(C)(C)C[C@H]2C3=CC[C@@H]4[C@@]5(C)CC[C@H](OC(=O)/C=C/c6ccccc6)C(C)(C)[C@@H]5CC[C@@]4(C)[C@]3(C)CC[C@@]12C(=O)O CHEMBL3114503 IC50 940.0 nM
CNc1nc2cc3ccccc3cc2c2c1ncn2C CHEMBL231036 IC50 950.0 nM
CN1CCN(CCCOc2ccc(N3C(=O)/C(=C/c4ccc(Oc5ccc(Br)cc5)cc4)SC3=S)cc2)CC1 CHEMBL3764998 IC50 960.0 nM
CC(=O)Nc1cccc(C#Cc2cc(C(N)=O)c(NC(N)=O)s2)c1 CHEMBL427008 IC50 964.0 nM
CC(=O)c1cc(C#Cc2cccc(NC(=O)c3cccc(NC(=O)c4ccccc4)c3)c2)sc1NC(N)=O CHEMBL1831212 IC50 964.0 nM
Nc1ncnc2cc(-c3ccccc3)sc12 CHEMBL311108 IC50 970.0 nM
NC(=O)Nc1sc(C#Cc2cccc(NC(=O)C(F)(F)F)c2)cc1C(N)=O CHEMBL371911 IC50 980.0 nM
NC(=O)Nc1sc(C#Cc2cccc(NC(=O)c3cccc(NC(=O)C(F)(F)F)c3)c2)cc1C(N)=O CHEMBL1831197 IC50 980.0 nM
O=S(=O)(Nc1ccc(-c2ccnc(Nc3ccc4ncsc4c3)n2)cc1)c1ccc(Cl)cc1 CHEMBL256347 IC50 990.0 nM