c1ccc(-c2cnc(Nc3ccc4cnccc4c3)o2)cc1 CHEMBL280793 IC50 5.0 nM
COc1cc2nc(-c3ccc(C)c(N4CCOCC4)c3)cc(O)c2cc1-c1cnco1 CHEMBL153794 IC50 5.0 nM
COc1cc2nc(-c3ccc(Br)cc3)cc(O)c2cc1-c1cnco1 CHEMBL152910 IC50 5.0 nM
COc1cc2nc(-c3cccc(C)c3)cc(O)c2cc1-c1cnco1 CHEMBL150777 IC50 5.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)O)C(=O)OC2 CHEMBL866 Ki 6.0 nM
COc1cc2nc(-c3ccc4c(c3)C(N(C)C)CC4)cc(O)c2cc1-c1cnco1 CHEMBL422508 IC50 6.0 nM
COc1cc2nc(-c3ccc4c(c3)C(N3CCC3)CC4)cc(O)c2cc1-c1cnco1 CHEMBL153118 IC50 6.0 nM
CC[C@H](CC#N)OC(=O)NCc1cccc(NC(=O)Nc2ccc(C#N)c(OC)c2)c1 CHEMBL118988 IC50 6.0 nM
CC(=O)OCC(=O)N(C)c1ccccc1-c1cnc(Nc2ccc3c(-c4cnco4)c[nH]c3c2)o1 CHEMBL109312 IC50 7.0 nM
COc1cc2nc(-c3ccccc3)cc(O)c2cc1-c1cnco1 CHEMBL23843 Ki 7.0 nM
CN(C)S(=O)(=O)c1cccc(C(C)(C)NC(=O)c2cc3[nH]c4ccccc4c(=O)c3cc2F)c1 CHEMBL230256 IC50 7.9 nM
C=Cc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)O)C(=O)OC2 CHEMBL131856 IC50 8.51 nM
COc1cc2nc(-c3ccsc3)cc(O)c2cc1-c1cnco1 CHEMBL347721 IC50 9.0 nM
COc1cc(NC(=O)Nc2cccc(CNC(=O)O[C@H]3CCOC3)c2)ccc1-c1cnco1 CHEMBL304087 IC50 10.0 nM
COc1cc(NC(=O)C(=O)NC(C)(C)C)ccc1-c1cnco1 CHEMBL25138 IC50 10.0 nM
CN(C)S(=O)(=O)c1ccc(C(C)(C)NC(=O)c2cc3[nH]c4ccccc4c(=O)c3cc2F)cc1 CHEMBL426531 IC50 10.0 nM
COc1cc(Nc2ncc(-c3ccccc3N(C)C(=O)Cn3cccn3)o2)ccc1-c1cnco1 CHEMBL68075 IC50 11.0 nM
COc1cc2nc(-c3ccc4c(c3)C(OC(=O)N(C)C)CC4)cc(O)c2cc1-c1cnco1 CHEMBL423952 IC50 11.0 nM
Cc1ccc(NC(=O)Nc2ccc3c(-c4cnco4)c[nH]c3c2)cc1 CHEMBL112967 IC50 11.0 nM
CC(C)(NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F)c1cccnc1 CHEMBL231660 IC50 11.0 nM
CC(C)(NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F)c1ccccc1 CHEMBL230734 IC50 11.0 nM
Cc1cc(C(C)(C)NC(=O)c2cc3[nH]c4ccccc4c(=O)c3cc2F)cnc1N1CCOCC1 CHEMBL228694 IC50 11.0 nM
COc1cc(Nc2ncc(-c3ccccc3N(C)C(=O)CN3CCOCC3)o2)ccc1-c1cnco1 CHEMBL64830 IC50 12.0 nM
COCC(=O)N(C)C1CCc2ccc(-c3cc(O)c4cc(-c5cnco5)c(OC)cc4n3)cc21 CHEMBL155617 IC50 12.0 nM
CNC1CCc2ccc(-c3cc(O)c4cc(-c5cnco5)c(OC)cc4n3)cc21 CHEMBL357309 IC50 12.0 nM
CC(C)(NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F)c1cccc(S(C)(=O)=O)c1 CHEMBL230148 IC50 12.0 nM
CC(C)(NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F)c1ccc(S(C)(=O)=O)cc1 CHEMBL230091 IC50 12.0 nM
CCc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)O)C(=O)OC2 CHEMBL132070 IC50 12.6 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)N[C@H](Cc1ccccc1)C(=O)NC[C@H]1O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]1O)C(=O)OC2 CHEMBL3098163 Ki 12.6 nM
COc1cc(Nc2ncc(-c3ccccc3N(C)C(=O)Cn3cncn3)o2)ccc1-c1cnco1 CHEMBL66614 IC50 13.0 nM
COc1cc(Nc2ncc(-c3ccccc3N(C)C(=O)CCN3CCOCC3)o2)ccc1-c1cnco1 CHEMBL67036 IC50 13.0 nM
COc1cc2nc(-c3ccc4c(c3)C(N3CCCC3)CC4)cc(O)c2cc1-c1cnco1 CHEMBL153389 IC50 13.0 nM
COc1cc2[nH]c(=S)n(CCc3ccncc3)c(=O)c2cc1-c1cnco1 CHEMBL182139 IC50 13.0 nM
CCc1c(C)c2c(c(O)c1C/C=C(\C)CNCCP(=O)(O)O)C(=O)OC2 CHEMBL208921 IC50 13.0 nM
COc1cc2nc(-c3ccc4c(c3)N(C(C)=O)CCO4)cc(O)c2cc1-c1cnco1 CHEMBL357949 IC50 14.0 nM
COc1cc2nc(-c3ccc4c(c3)CN(C)C4)cc(O)c2cc1-c1cnco1 CHEMBL154752 IC50 14.0 nM
CN(C)c1cc(C(C)(C)NC(=O)c2cc3[nH]c4ccccc4c(=O)c3cc2F)ccn1 CHEMBL228957 IC50 14.0 nM
CCc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]4O[C@@H](c5nc(C(N)=O)cs5)[C@H](O)[C@@H]4O)[C@@H](O)[C@H]3O)c2n1 CHEMBL392203 Ki 14.0 nM
CCc1nc(N)c2ncn([C@H]3O[C@@H](COP(=O)(O)OP(=O)(O)OC[C@H]4O[C@@H](c5nc(C(N)=O)cs5)[C@H](O)[C@@H]4O)[C@H](O)[C@@H]3O)c2n1 CHEMBL1683637 Ki 14.0 nM
COc1c(C)c2c(c(O)c1CCOP(=O)(O)CP(=O)(O)OC[C@H]1O[C@@H](n3cnc4c(N)nc(-c5ccncc5)nc43)[C@H](O)[C@@H]1O)C(=O)OC2 CHEMBL3098189 Ki 14.0 nM
COc1cc(Nc2ncc(-c3ccccc3N(C)C(=O)CN(C)C)o2)ccc1-c1cnco1 CHEMBL63158 IC50 15.0 nM
COc1cc2nc(-c3ccc(C)c(N4CCCC4)c3)cc(O)c2cc1-c1cnco1 CHEMBL359344 IC50 15.0 nM
COc1cc2nc(-c3ccc4c(c3)[C@@H](N(C)C)[C@H](OC)C4)cc(O)c2cc1-c1cnco1 CHEMBL434894 IC50 15.0 nM
COc1cc2nc(-c3ccc4c(c3)C(N(C)C)CCC4)cc(O)c2cc1-c1cnco1 CHEMBL357291 IC50 15.0 nM
COc1c(C)c2c(c(O)c1CCOP(=O)(O)CP(=O)(O)OC[C@H]1O[C@@H](n3cnc4c(N)nc(C(F)(F)F)nc43)[C@H](O)[C@@H]1O)C(=O)OC2 CHEMBL3098188 Ki 15.0 nM
COc1cc2nc(-c3cccc(N4CCN(C)CC4)c3)cc(O)c2cc1-c1cnco1 CHEMBL149699 IC50 16.0 nM
COc1cc(Nc2ncc(-c3ccccc3)o2)ccc1-c1cnco1 CHEMBL64639 IC50 16.0 nM
COc1cc(N/C(=N/c2cccc(C/N=C(\NC#N)Oc3ccccc3)c2)NC#N)ccc1-c1cnco1 CHEMBL101984 IC50 16.0 nM
COc1cc(Nc2ncc(-c3ccccc3N(C)C(=O)CN3CCN(C)CC3)o2)ccc1-c1cnco1 CHEMBL302967 IC50 17.0 nM
COc1cc2[nH]c(=S)n(C)c(=O)c2cc1-c1cnco1 CHEMBL180007 IC50 17.0 nM
CCN1CCN(c2ccc(C(C)(C)NC(=O)c3cc4[nH]c5ccccc5c(=O)c4cc3F)cn2)CC1 CHEMBL229008 IC50 17.0 nM
CC(C)(NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F)c1cnc2c(c1)OCCN2 CHEMBL230578 IC50 17.0 nM
Cc1cccc(NC(=O)Nc2ccc3cnccc3c2)c1 CHEMBL27948 IC50 18.0 nM
COc1cc(Nc2ncc(-c3ccccc3N(C)C(C)=O)o2)ccc1-c1cnco1 CHEMBL306453 IC50 18.0 nM
COc1cc2nc(-c3ccc4c(c3)C(N(C)C(C)=O)CC4)cc(O)c2cc1-c1cnco1 CHEMBL153516 IC50 18.0 nM
COc1cc2nc(-c3ccc4c(c3)C(N(C)C(=O)CN3CCOCC3)CC4)cc(O)c2cc1-c1cnco1 CHEMBL154867 IC50 18.0 nM
COc1cc2nc(-c3cccc(O)c3)cc(O)c2cc1-c1cnco1 CHEMBL150728 IC50 18.0 nM
COc1cc(Nc2nc(O)nc(-c3ccccc3)n2)ccc1-c1cnco1 CHEMBL430998 IC50 18.0 nM
COc1cc(NC(=O)C(=O)NC2(CO)CCCC2)ccc1-c1cnco1 CHEMBL416932 IC50 18.0 nM
C/C(=C\Cc1c(C)c(C)c2c(c1O)C(=O)OC2)CCC(=O)O CHEMBL443814 IC50 18.6 nM
COc1cc(NC(=O)Nc2cccc(C)c2)ccc1-c1cnco1 CHEMBL65013 IC50 19.0 nM
COc1cc2nc(-c3ccc(C)c(Br)c3)cc(O)c2cc1-c1cnco1 CHEMBL356371 IC50 19.0 nM
COc1cc(NC(=O)C(=O)NC(C)(C)CO)ccc1-c1cnco1 CHEMBL27777 IC50 19.0 nM
CC(C)(NC(=O)c1ccc2c(=O)c3ccccc3[nH]c2c1)c1ccccc1 CHEMBL394618 IC50 19.0 nM
COc1cc(Nc2ncc(-c3ccccc3N(C)C(=O)CNC(C)(C)C)o2)ccc1-c1cnco1 CHEMBL417047 IC50 20.0 nM
COc1cc2nc(-c3ccc4c(c3)C(N3CCOCC3)CC4)cc(O)c2cc1-c1cnco1 CHEMBL153411 IC50 20.0 nM
CCc1c(C)c2c(c(O)c1C/C=C(\C)CP(=O)(O)O)C(=O)OC2 CHEMBL428633 IC50 20.0 nM
COc1cc(C(C)(C)NC(=O)c2cc3[nH]c4ccccc4c(=O)c3cc2F)cnc1N1CCOCC1 CHEMBL228691 IC50 20.0 nM
CC(C)(NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F)c1ccc(N2CCOCC2)nc1 CHEMBL387709 IC50 20.0 nM
CN(C)CCOc1ccc(C(C)(C)NC(=O)c2cc3[nH]c4ccccc4c(=O)c3cc2F)cc1 CHEMBL230090 IC50 20.0 nM
COc1cc2nc(-c3ccc(N4CCOCC4)cc3)cc(O)c2cc1-c1cnco1 CHEMBL149755 IC50 21.0 nM
COc1cc2nc(-c3ccc4c(c3)C(N(C)C)CCO4)cc(O)c2cc1-c1cnco1 CHEMBL153773 IC50 21.0 nM
COc1cc(Nc2ncc(-c3ccccc3N(C)C(=O)CO)o2)ccc1-c1cnco1 CHEMBL302827 IC50 21.0 nM
CN(C(=O)CO)c1ccccc1-c1cnc(Nc2ccc(-c3cnco3)c(Br)c2)o1 CHEMBL62748 IC50 21.0 nM
NC(=O)c1c[se]c([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)n1 CHEMBL451855 Ki 21.0 nM
CNCC(=O)N(C)c1ccccc1-c1cnc(Nc2ccc(-c3cnco3)c(OC)c2)o1 CHEMBL305977 IC50 22.0 nM
COc1cc2nc(-c3cccc(Br)c3)cc(O)c2cc1-c1cnco1 CHEMBL153241 IC50 22.0 nM
COc1cc2[nH]c(=S)n(CCCn3ccnc3)c(=O)c2cc1-c1cnco1 CHEMBL182242 IC50 22.0 nM
CN(C)c1ccc(C(C)(C)NC(=O)c2cc3[nH]c4ccccc4c(=O)c3cc2F)cn1 CHEMBL230581 IC50 22.0 nM
COc1cc(Nc2ncc(-c3ccccc3OC)o2)ccc1-c1cnco1 CHEMBL302748 IC50 23.0 nM
CCc1c(C)c2c(c(O)c1C/C=C(\C)COCP(=O)(O)O)C(=O)OC2 CHEMBL209069 IC50 23.0 nM
Cc1ccc(C(C)(C)NC(=O)c2cc3[nH]c4ccccc4c(=O)c3cc2F)cn1 CHEMBL230579 IC50 23.0 nM
CCc1c(C)c2c(c(O)c1C/C=C(\C)CN(CCP(=O)(O)O)S(N)(=O)=O)C(=O)OC2 CHEMBL380059 IC50 24.0 nM
CCc1nc(N)c2ncn([C@H]3O[C@@H](COP(=O)(O)C(F)(F)P(=O)(O)OCCc4c(O)c5c(c(C)c4OC)COC5=O)[C@H](O)[C@@H]3O)c2n1 CHEMBL1683640 Ki 24.0 nM
CCc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)C(F)(F)P(=O)(O)OCCc4c(O)c5c(c(C)c4OC)COC5=O)[C@@H](O)[C@H]3O)c2n1 CHEMBL3098187 Ki 24.0 nM
COc1cc(Nc2ncc(-c3ccccc3C)o2)ccc1-c1cnco1 CHEMBL67346 IC50 25.0 nM
COc1cc2nc(-c3cccc(N4CCCC4)c3)cc(O)c2cc1-c1cnco1 CHEMBL153702 IC50 25.0 nM
COc1cc2nc(-c3ccc(C)c(N4CCN(C)CC4)c3)cc(O)c2cc1-c1cnco1 CHEMBL153429 IC50 26.0 nM
COc1cc(Nc2nc(C)c(-c3ccccc3)o2)ccc1-c1cnco1 CHEMBL261978 IC50 27.0 nM
NC(=O)c1csc([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)nc(N)nc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)n1 CHEMBL409560 Ki 27.0 nM
COc1ccc(N2CCN(C)CC2)cc1Nc1ncc2c(n1)-c1c(c(C(N)=O)nn1C)CC2 CHEMBL1094408 Kd apparent 27.0 nM
COc1cc2nc(-c3ccc4c(c3)C(O)CC4)cc(O)c2cc1-c1cnco1 CHEMBL153247 IC50 28.0 nM
CN(C(=O)CN1CCOCC1)c1ccccc1-c1cnc(Nc2ccc(-c3cnco3)c(Br)c2)o1 CHEMBL305374 IC50 28.0 nM
COc1cc(NC(=O)/C=C/c2ccco2)ccc1-c1cnco1 CHEMBL64609 IC50 28.0 nM
COc1cc2nc(-c3cc(C)ccc3C)cc(O)c2cc1-c1cnco1 CHEMBL345992 IC50 29.0 nM
CC(C)(NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F)c1ccccn1 CHEMBL230841 IC50 29.0 nM
COc1cc(Nc2ncc(-c3ccccc3NC(C)=O)o2)ccc1-c1cnco1 CHEMBL65826 IC50 30.0 nM
COc1cc2nc(-c3ccc4c(c3)C([N+](C)(C)C)CC4)cc(O)c2cc1-c1cnco1 CHEMBL155616 IC50 30.0 nM
COc1cc2[nH]c(-c3csc4ccccc34)c(C=O)c2cc1-c1cnco1 CHEMBL23716 IC50 30.0 nM
COc1cc(NC(=O)C(=O)NC(C)(C)c2ccccc2)ccc1-c1cnco1 CHEMBL25681 IC50 30.0 nM
COc1cc(NC(=O)C(=O)Nc2cccc(CNC(=O)O[C@@H]3CCOC3)c2)ccc1-c1cnco1 CHEMBL25179 IC50 30.0 nM
COc1cc2nc(S)nc(O)c2cc1-c1cnco1 CHEMBL180663 IC50 30.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)NO)C(=O)OC2 CHEMBL238461 Ki 30.0 nM
CCc1nc(N)c2ncn([C@H]3O[C@@H](COP(=O)(O)C(F)(F)P(=O)(O)OC[C@H]4O[C@@H](c5nc(C(N)=O)cs5)[C@H](O)[C@@H]4O)[C@H](O)[C@@H]3O)c2n1 CHEMBL1683638 Ki 30.0 nM
COc1cc2nc(-c3ccoc3)cc(O)c2cc1-c1cnco1 CHEMBL153387 IC50 32.0 nM
COc1cc(Nc2nc(OCc3ccccc3)nc(-c3ccccc3)n2)ccc1-c1cnco1 CHEMBL303048 IC50 32.0 nM
COc1cc2nc(-c3ccc4c(c3)C(N3CCCC3)CCO4)cc(O)c2cc1-c1cnco1 CHEMBL153175 IC50 33.0 nM
Cn1cc(C#N)c2ccc(Nc3ncc(-c4ccccc4)o3)cc21 CHEMBL331535 IC50 33.0 nM
COc1c(C)c(C)c(Cl)c(O)c1C/C=C(\C)CCC(=O)O CHEMBL132413 IC50 33.5 nM
COc1cc2nc(-c3cscn3)cc(O)c2cc1-c1cnco1 CHEMBL153032 IC50 34.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CNCc1cn(C[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)nn1)C(=O)OC2 CHEMBL1170849 Ki 34.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CNCc1cn(C[C@@H]3O[C@H](n4cnc5c(N)ncnc54)[C@@H](O)[C@H]3O)nn1)C(=O)OC2 CHEMBL1683755 Ki 34.0 nM
Cc1ccccc1NC(=O)Nc1ccc2c(-c3cnco3)c[nH]c2c1 CHEMBL116061 IC50 35.0 nM
CN(C(=O)CN1CCOCC1)c1ccccc1-c1cnc(Nc2ccc3c(-c4cnco4)c[nH]c3c2)o1 CHEMBL112405 IC50 35.0 nM
COc1cc(NC(=O)/C=C/c2ccccc2C)ccc1-c1cnco1 CHEMBL99258 IC50 35.0 nM
COC(=O)[C@H]1C[C@]2(CN1C(=O)OC(C)(C)C)Nc1cc(OC)c(-c3cnco3)cc1C(=O)N2C CHEMBL202190 IC50 35.0 nM
COc1c(C)c(C)c(Br)c(O)c1C/C=C(\C)CCC(=O)O CHEMBL132404 IC50 36.7 nM
COc1c(C)c2c(c(O)c1CCOP(=O)(O)OCP(=O)(O)OCC1OC(n3cnc4c(N)ncnc43)[C@@H](O)[C@H]1O)C(=O)OC2 CHEMBL384114 Ki 37.0 nM
COc1c(C)c2c(c(O)c1CCOP(=O)(O)OCP(=O)(O)OC[C@@H]1O[C@H](n3cnc4c(N)ncnc43)[C@@H](O)[C@H]1O)C(=O)OC2 CHEMBL1683743 Ki 37.0 nM
COc1c(C)c2c(c(O)c1CCOP(=O)(O)CP(=O)(O)OC[C@H]1O[C@@H](n3cnc4c(N)nc(-c5ccco5)nc43)[C@H](O)[C@@H]1O)C(=O)OC2 CHEMBL3098190 Ki 37.0 nM
Cc1ccccc1-c1cnc(Nc2ccc3c(-c4cnco4)c[nH]c3c2)o1 CHEMBL113572 IC50 38.0 nM
CCc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)CP(=O)(O)OCCc4c(O)c5c(c(C)c4OC)COC5=O)[C@@H](O)[C@H]3O)c2n1 CHEMBL392204 Ki 38.0 nM
CCc1nc(N)c2ncn([C@H]3O[C@@H](COP(=O)(O)CP(=O)(O)OCCc4c(O)c5c(c(C)c4OC)COC5=O)[C@H](O)[C@@H]3O)c2n1 CHEMBL1683639 Ki 38.0 nM
COc1c(C)c2c(c(O)c1CCOP(=O)(O)CCSC[C@@H]1O[C@H](n3cnc4c(N)ncnc43)[C@@H](O)[C@H]1O)C(=O)OC2 CHEMBL1683752 Ki 39.0 nM
O=C(Nc1ccccc1)Nc1ccc2c(-c3cnco3)c[nH]c2c1 CHEMBL112993 IC50 40.0 nM
Cn1cc(C#N)c2ccc(Nc3ncc(-c4cccc(CNC(=O)c5ccc6ccccc6c5)c4)o3)cc21 CHEMBL119408 IC50 40.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)N[C@H](Cc1c[nH]c3ccccc13)C(=O)NC[C@H]1O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]1O)C(=O)OC2 CHEMBL3098169 Ki 40.0 nM
COc1nc(Nc2ccc(-c3cnco3)c(OC)c2)nc(-c2ccccc2)n1 CHEMBL68221 IC50 41.0 nM
COc1cc(Nc2ncc(-c3ccccc3N(C)C(=O)CO)o2)ccc1-c1cocn1 CHEMBL62934 IC50 41.0 nM
CN(C(=O)CO)c1ccccc1-c1cnc(Nc2ccc(-c3cnco3)c(Cl)c2)o1 CHEMBL63122 IC50 41.0 nM
CC(C)(NC(=O)c1ccc2c(=O)c3ccccc3[nH]c2c1)c1cccnc1 CHEMBL397960 IC50 42.0 nM
COc1cc2nc(-c3ccccn3)cc(O)c2cc1-c1cnco1 CHEMBL153511 IC50 43.0 nM
COc1cc2nc(-c3ccc(O)cc3)cc(O)c2cc1-c1cnco1 CHEMBL153014 IC50 43.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cnco3)c(Cl)c2)c1 CHEMBL292258 IC50 43.0 nM
COc1cc(Nc2nnc(-c3ccccc3)o2)ccc1-c1cnco1 CHEMBL420288 IC50 44.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)Cn1cc(COC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)nn1)C(=O)OC2 CHEMBL1170851 Ki 44.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CNCn1cc(OC[C@@H]3O[C@H](n4cnc5c(N)ncnc54)[C@@H](O)[C@H]3O)nn1)C(=O)OC2 CHEMBL1683754 Ki 44.0 nM
COc1c(C)c2c(c(O)c1CCOP(=O)(O)CP(=O)(O)OC[C@H]1O[C@@H](n3cnc4c(N)nc(COCc5ccccc5)nc43)[C@H](O)[C@@H]1O)C(=O)OC2 CHEMBL3098192 Ki 44.0 nM
Cc1cc(Nc2ncc(-c3ccccc3N(C)C(=O)CN3CCOCC3)o2)ccc1-c1cnco1 CHEMBL62496 IC50 45.0 nM
CCN(CC)C(=O)N1CCC2(C1)Nc1cc(OC)c(-c3cnco3)cc1C(=O)N2C CHEMBL198729 IC50 45.0 nM
COc1cc2nc(-c3ccncc3)cc(O)c2cc1-c1cnco1 CHEMBL151220 IC50 46.0 nM
CN(C(=O)CN1CCOCC1)c1ccccc1-c1cnc(Nc2ccc(-c3cnco3)c(Cl)c2)o1 CHEMBL293162 IC50 47.0 nM
COc1cc(NC(=O)C(=O)NC(C)(C)CN(C)C)ccc1-c1cnco1 CHEMBL24840 IC50 47.0 nM
COc1cc2[nH]c(=O)n(CCc3c[nH]cn3)c(=O)c2cc1-c1cnco1 CHEMBL179231 IC50 47.0 nM
COc1cc2c(cc1-c1cnco1)C(=O)N(C)C(C)(/C=C/c1ccccc1)N2 CHEMBL382509 IC50 49.0 nM
C#Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]4O[C@@H](c5nc(C(N)=O)cs5)[C@H](O)[C@@H]4O)[C@@H](O)[C@H]3O)c2n1 CHEMBL235533 Ki 49.0 nM
CC(C)(C)NC(=O)C(=O)Nc1ccc(-c2cnco2)c(Br)c1 CHEMBL24866 IC50 50.0 nM
C/C(=C\Cc1c(O)c2c(c(C)c1C1CC1)COC2=O)CCC(=O)O CHEMBL132355 IC50 50.7 nM
COc1cc2c(cc1-c1cnco1)C(=O)N(C)C1(CCN(C(=O)N(C)c3ccc(F)cc3F)C1)N2 CHEMBL199075 IC50 51.0 nM
COc1cc(NC(=O)C(=O)Nc2ccccc2)ccc1-c1cnco1 CHEMBL283256 IC50 52.0 nM
COc1cc2nc(-c3ccc(N4CCN(C)CC4)cc3)cc(O)c2cc1-c1cnco1 CHEMBL152978 IC50 53.0 nM
CC(C)(NC(=O)c1ccc2c(=O)c3ccccc3[nH]c2c1)c1ccncc1 CHEMBL230733 IC50 53.0 nM
CC(C)(NC(=O)c1ccc2c(=O)c3ccccc3[nH]c2c1)c1ccccn1 CHEMBL389115 IC50 53.0 nM
COc1cc(Nc2nc(N)nc(-c3ccccc3)n2)ccc1-c1cnco1 CHEMBL66782 IC50 54.0 nM
COc1cc2nc(-c3ccc4c(c3)CCC4N(C)C)cc(O)c2cc1-c1cnco1 CHEMBL150631 IC50 55.0 nM
CC(C)(C)NC(=O)C(=O)Nc1ccc(-c2cnco2)c(Cl)c1 CHEMBL24092 IC50 55.0 nM
COc1c(C)c2c(c(O)c1CCOP(=O)(O)CP(=O)(O)OC[C@H]1O[C@@H](n3cnc4c(N)nc(-c5cccs5)nc43)[C@H](O)[C@@H]1O)C(=O)OC2 CHEMBL3098191 Ki 56.0 nM
CNc1nc(Nc2ccc(-c3cnco3)c(OC)c2)nc(-c2ccco2)n1 CHEMBL67163 IC50 57.0 nM
COc1cc(NC(=O)/C=C/c2ccc3ccccc3n2)ccc1-c1cnco1 CHEMBL316622 IC50 57.0 nM
COc1cc(NC(=O)/C=C/c2ccncc2)ccc1-c1cnco1 CHEMBL98224 IC50 57.0 nM
COc1cc(Nc2nc(NCCc3cccnc3)nc(-c3ccccc3)n2)ccc1-c1cnco1 CHEMBL444052 IC50 58.0 nM
COc1cc(Nc2noc(-c3ccccc3)n2)ccc1-c1cnco1 CHEMBL104051 IC50 59.0 nM
CC(C)(C)NC(=O)c1ccc2c(=O)c3ccccc3[nH]c2c1 CHEMBL230198 IC50 59.0 nM
c1ccc(-c2cnc(Nc3ccc4cncnc4c3)o2)cc1 CHEMBL285813 IC50 60.0 nM
COc1cc(NC(=O)/C=C/c2ccccc2Cl)ccc1-c1cnco1 CHEMBL421004 IC50 60.0 nM
COc1c(C)c2c(c(O)c1CCOP(=O)(O)COP(=O)(O)OCC1OC(n3cnc4c(N)ncnc43)[C@@H](O)[C@H]1O)C(=O)OC2 CHEMBL215311 Ki 60.0 nM
COc1c(C)c2c(c(O)c1CCOP(=O)(O)COP(=O)(O)OC[C@@H]1O[C@H](n3cnc4c(N)ncnc43)[C@@H](O)[C@H]1O)C(=O)OC2 CHEMBL1683742 Ki 60.0 nM
COc1cc2nc(-c3cccs3)cc(O)c2cc1-c1cnco1 CHEMBL153223 IC50 63.0 nM
COc1cc2[nH]c(-c3csc4ccccc34)c(C#N)c2cc1-c1cnco1 CHEMBL283096 IC50 64.0 nM
COc1cc2c(cc1-c1cnco1)C(=O)N(C)C1(CCN(C(=O)N(C)c3ccccc3)C1)N2 CHEMBL370575 IC50 64.0 nM
COc1cc2nc(-c3ccccc3C)cc(O)c2cc1-c1cnco1 CHEMBL359340 IC50 65.0 nM
COc1cc2nc(-c3ccccc3)c(C)c(O)c2cc1-c1cnco1 CHEMBL153187 IC50 65.0 nM
COc1cc(NC(=O)/C=C/c2cccs2)ccc1-c1cnco1 CHEMBL430865 IC50 66.0 nM
COc1cc2nc(-c3ccc4c(c3)C(N(C)C(=O)Cn3ccnc3)CC4)cc(O)c2cc1-c1cnco1 CHEMBL153595 IC50 68.0 nM
COc1cc2c(cc1-c1cnco1)C(=O)N(C)C1(CCN(C(=O)N3CCCCC3)C1)N2 CHEMBL198526 IC50 68.0 nM
CCc1c(C)c2c(c(O)c1C/C=C(\C)CN(CCP(=O)(O)O)S(C)(=O)=O)C(=O)OC2 CHEMBL212620 IC50 68.0 nM
C/C(=C\Cc1c(C)c(C)c(C)c(Cl)c1O)CCC(=O)O CHEMBL335446 IC50 69.3 nM
COc1cc(Nc2ncc(-c3cccc(C)c3)o2)ccc1-c1cnco1 CHEMBL67794 IC50 70.0 nM
COc1cc2nc(-c3cccnc3)cc(O)c2cc1-c1cnco1 CHEMBL424508 IC50 70.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)N[C@H](C(=O)NC[C@H]1O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]1O)C(C)C)C(=O)OC2 CHEMBL3098183 Ki 70.0 nM
COc1cc2[nH]c(=S)n(CCN3CCOCC3)c(=O)c2cc1-c1cnco1 CHEMBL368056 IC50 71.0 nM
COc1cc2c(cc1-c1cnco1)C(=O)N(C)C1(CCN(C(=O)N(C(C)C)C(C)C)C1)N2 CHEMBL196912 IC50 71.0 nM
COc1cc(Nc2nc(-c3ccccc3)nc(N3CCC[C@H]3CO)n2)ccc1-c1cnco1 CHEMBL67839 IC50 72.0 nM
COc1cc(NC(=O)/C=C/c2ccccc2)ccc1-c1cnco1 CHEMBL99451 IC50 73.0 nM
CCc1nc(N)c2ncn([C@H]3O[C@@H](COP(=O)(O)CCP(=O)(O)OCCc4c(O)c5c(c(C)c4OC)COC5=O)[C@H](O)[C@@H]3O)c2n1 CHEMBL1683745 Ki 73.0 nM
COC(=O)C(C)(C)NC(=O)C(=O)Nc1ccc(-c2cnco2)c(OC)c1 CHEMBL25027 IC50 74.0 nM
COc1cc(NC(=O)/C=C/c2c(C)cc(F)cc2C)ccc1-c1cnco1 CHEMBL314330 IC50 75.0 nM
CNc1nc(Nc2ccc(-c3cnco3)c(OC)c2)nc(-c2ccccc2)n1 CHEMBL433062 IC50 76.0 nM
O=C(NOCc1ccccc1)Nc1ccc2c(-c3ccncc3)c[nH]c2c1 CHEMBL380639 IC50 76.0 nM
Cc1cccc(-c2cnc(Nc3ccc4c(-c5cnco5)c[nH]c4c3)o2)c1 CHEMBL423873 IC50 77.0 nM
COc1cc(Nc2nc(-c3ccccc3)nc(N3CCC[C@@H]3CO)n2)ccc1-c1cnco1 CHEMBL303608 IC50 78.0 nM
COc1cc(Nc2nc(NCCCC(=O)O)nc(-c3ccccc3)n2)ccc1-c1cnco1 CHEMBL66455 IC50 78.0 nM
COc1cc2c(cc1-c1cnco1)C(=O)N(C)C1(CCN(C(=O)N(C)OC)C1)N2 CHEMBL372753 IC50 79.0 nM
CCOC(=O)N1CCC2(C1)Nc1cc(OC)c(-c3cnco3)cc1C(=O)N2C CHEMBL197163 IC50 80.0 nM
COc1cc2nc(-c3ccc4c(c3)C(O)CCC4)cc(O)c2cc1-c1cnco1 CHEMBL153771 IC50 83.0 nM
COc1c(C)c2c(c(O)c1CCOP(=O)(O)CC(=O)NC[C@@H]1O[C@H](n3cnc4c(N)ncnc43)[C@@H](O)[C@H]1O)C(=O)OC2 CHEMBL1683749 Ki 83.0 nM
Cn1cc(C#N)c2ccc(Nc3ncc(-c4cccc(CNC(=O)c5cccc6ccccc56)c4)o3)cc21 CHEMBL118714 IC50 84.0 nM
CN(C(=O)Nc1ccc2c(-c3ccncc3)c[nH]c2c1)c1ccccc1 CHEMBL206886 IC50 84.0 nM
NC(=O)c1csc([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)nc(I)nc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)n1 CHEMBL394277 Ki 84.0 nM
COc1c(C)c2c(c(O)c1CCOP(=O)(O)CCP(=O)(O)OC[C@@H]1O[C@H](n3cnc4c(N)ncnc43)[C@@H](O)[C@H]1O)C(=O)OC2 CHEMBL1683744 Ki 84.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)NC[C@H]1O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]1O)C(=O)OC2 CHEMBL3098182 Ki 84.0 nM
COc1cc(Nc2ncc(-c3ccc(C)cc3)o2)ccc1-c1cnco1 CHEMBL302558 IC50 85.0 nM
CCc1nc(Nc2ccc(-c3cnco3)c(OC)c2)oc1-c1ccccc1 CHEMBL65962 IC50 86.0 nM
COc1cc2[nH]c(=O)n(CCn3ccnc3)c(=O)c2cc1-c1cnco1 CHEMBL180310 IC50 86.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCCP(=O)(O)O)C(=O)OC2 CHEMBL211023 IC50 86.0 nM
C/C(=C\Cc1c(O)c(C)c2c(c1O)C(=O)OC2)CCC(=O)O CHEMBL132727 IC50 87.7 nM
Clc1cc(Nc2ncc(-c3ccccc3)o2)ccc1-c1cnco1 CHEMBL62986 IC50 88.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)N[C@@H](C(=O)NC[C@H]1O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]1O)C(C)C)C(=O)OC2 CHEMBL3098184 Ki 88.0 nM
CCOc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)O)C(=O)OC2 CHEMBL337240 IC50 89.8 nM
NC(=O)c1csc([C@H]2O[C@@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)[C@H](O)[C@@H]2O)n1 CHEMBL2364562 IC50 90.0 nM
COc1cc(Nc2ncc(-c3ccccc3N(C)C(=O)CN3CCOCC3)o2)ccc1-c1cocn1 CHEMBL302609 IC50 91.0 nM
COc1cc2[nH]c(=S)n(CCc3ccccn3)c(=O)c2cc1-c1cnco1 CHEMBL180088 IC50 91.0 nM
c1ccc(-c2cnc(Nc3ccc4c(-c5cnco5)c[nH]c4c3)o2)cc1 CHEMBL109335 IC50 93.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CN(CCP(=O)(O)O)S(N)(=O)=O)C(=O)OC2 CHEMBL380155 IC50 93.0 nM
CC(=O)NCc1ccc(-c2cnc(Nc3ccc4c(C#N)cn(C)c4c3)o2)cc1 CHEMBL119208 IC50 94.0 nM
COc1cc2c(cc1-c1cnco1)C(=O)N(C)C1(CCN(C(=O)C(C)(C)C)C1)N2 CHEMBL198536 IC50 94.0 nM
C=Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]4O[C@@H](c5nc(C(N)=O)cs5)[C@H](O)[C@@H]4O)[C@@H](O)[C@H]3O)c2n1 CHEMBL429702 Ki 94.0 nM
COC(=O)[C@H](CO)NC(=O)CC/C(C)=C/Cc1c(O)c2c(c(C)c1OC)COC2=O CHEMBL3098172 Ki 94.0 nM
C[C@@H](NC(=O)c1ccc2c(=O)c3ccccc3[nH]c2c1)c1ccccc1 CHEMBL389085 IC50 95.0 nM
COc1cc2c(cc1-c1cnco1)C(=O)N(C)C1(Cc3ccsc3C1)N2 CHEMBL197546 IC50 96.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCP(=O)(O)O)C(=O)OC2 CHEMBL210910 IC50 96.0 nM
COc1cccc(-c2cnc(Nc3ccc(-c4cnco4)c(OC)c3)o2)c1 CHEMBL430981 IC50 97.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)Nc1ncn[nH]1)C(=O)OC2 CHEMBL2418580 IC50 98.0 nM
Cn1cc(C#N)c2ccc(Nc3ncc(-c4ccc(CNC(=O)c5ccccc5)cc4)o3)cc21 CHEMBL119655 IC50 100.0 nM
Cc1cc(Nc2ncc(-c3ccccc3N(C)C(=O)CO)o2)ccc1-c1cnco1 CHEMBL293640 IC50 100.0 nM
CCc1cc(Nc2ncc(-c3ccccc3N(C)C(=O)CO)o2)ccc1-c1cnco1 CHEMBL62467 IC50 100.0 nM
COc1cc2[nH]c(=S)n(Cc3ccncc3)c(=O)c2cc1-c1cnco1 CHEMBL414657 IC50 100.0 nM
NC(=O)c1csc([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)n1 CHEMBL394276 Ki 100.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)OC[C@H]1O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]1O)C(=O)OC2 CHEMBL3098180 Ki 102.0 nM
CNC(=O)c1ccccc1-c1cnc(Nc2ccc(-c3cnco3)c(OC)c2)o1 CHEMBL305786 IC50 104.0 nM
COc1cc2[nH]c(=O)n(C)c(=O)c2cc1-c1cnco1 CHEMBL360022 IC50 104.0 nM
COc1cc2c(cc1-c1cnco1)C(=O)N(C)C1(CCN(C(=O)OC(C)(C)C)C1)N2 CHEMBL371533 IC50 104.0 nM
COc1c(C)c2c(c(O)c1CCOP(=O)(O)CP(=O)(O)OC[C@H]1O[C@@H](n3cnc4c(N)nc(-c5ccccc5)nc43)[C@H](O)[C@@H]1O)C(=O)OC2 CHEMBL410745 Ki 108.0 nM
NC(=O)c1csc([C@@H]2O[C@H](COP(=O)(O)CP(=O)(O)OC[C@@H]3O[C@H](n4cnc5c(N)ncnc54)[C@@H](O)[C@H]3O)[C@@H](O)[C@H]2O)n1 CHEMBL3144029 Ki 110.0 nM
COc1cc(NC2=NCC(c3ccccc3)O2)ccc1-c1cnco1 CHEMBL104535 IC50 110.0 nM
COc1cc(-c2ccccc2)nc(Nc2ccc(-c3cnco3)c(OC)c2)n1 CHEMBL104313 IC50 110.0 nM
COc1cc2nc(C)cc(O)c2cc1-c1cnco1 CHEMBL150487 IC50 110.0 nM
COc1cc(N/C(=N/c2cccc(CNC(=O)OCC3CCOC3)c2)NC#N)ccc1-c1cnco1 CHEMBL98265 IC50 110.0 nM
COc1ccccc1/C=C/C(=O)Nc1ccc(-c2cnco2)c(OC)c1 CHEMBL319883 IC50 110.0 nM
COc1cc(NC(=O)c2ccc(C)s2)ccc1-c1cnco1 CHEMBL95383 IC50 110.0 nM
COc1cc(NC(=O)c2cc3ccccc3[nH]2)ccc1-c1cnco1 CHEMBL95601 IC50 110.0 nM
COc1ccc(-c2cnc(Nc3ccc(-c4cnco4)c(OC)c3)o2)cc1 CHEMBL66012 IC50 115.0 nM
CCNC(=O)N1CCC2(C1)Nc1cc(OC)c(-c3cnco3)cc1C(=O)N2C CHEMBL373029 IC50 119.0 nM
COc1cc(Nc2cc(-c3ccccc3)on2)ccc1-c1cnco1 CHEMBL107337 IC50 120.0 nM
COc1cc(NC(=O)/C=C/c2ccc(F)cc2)ccc1-c1cnco1 CHEMBL100403 IC50 120.0 nM
COc1cc(NC(=O)Nc2cccc(/C=C/C(=O)NO)c2)ccc1-c1cnco1 CHEMBL1215244 Ki(app) 120.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)O)C(=O)SC2 CHEMBL135788 IC50 121.0 nM
COc1c(C/C=C(\C)CCC(=O)O)c(O)c2c(c1OC)COC2=O CHEMBL132892 IC50 126.0 nM
CCOC(=O)c1ccccc1-c1cnc(Nc2ccc(-c3cnco3)c(OC)c2)o1 CHEMBL307084 IC50 127.0 nM
Cc1[nH]c2cc(NC(=O)N(C)c3ccccc3)ccc2c1-c1ccncc1 CHEMBL208219 IC50 128.0 nM
CNc1nc(Nc2ccc(-c3cnco3)c(OC)c2)nc(N2CCC[C@H]2CO)n1 CHEMBL420547 IC50 130.0 nM
COc1cc(Nc2nc(NCCC(=O)O)nc(-c3ccccc3)n2)ccc1-c1cnco1 CHEMBL304521 IC50 130.0 nM
CNc1nc(Nc2ccc(-c3cnco3)c(OC)c2)nc(-c2cccc(C)c2)n1 CHEMBL305059 IC50 130.0 nM
COc1cc2[nH]c(-c3ccccc3)c(C#N)c2cc1-c1cnco1 CHEMBL23842 IC50 130.0 nM
Cn1cc(C#N)c2ccc(Nc3ncc(-c4cccc(CNC(=O)c5ccccc5)c4)o3)cc21 CHEMBL333901 IC50 130.0 nM
CCCCNC(=O)c1cccc(N/C(=N/c2ccc(-c3cnco3)c(OC)c2)NC#N)c1 CHEMBL101941 IC50 130.0 nM
C/C(=C\Cc1c(O)c2c(c(C)c1-c1ccccc1)COC2=O)CCC(=O)O CHEMBL335272 IC50 130.0 nM
COc1cc(NC(=O)c2cc3ccccc3n2C)ccc1-c1cnco1 CHEMBL329952 IC50 130.0 nM
COc1cc(NC(=O)c2ccc(C(C)(C)C)o2)ccc1-c1cnco1 CHEMBL97097 IC50 130.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)Nc1ccc(Cl)cc1)C(=O)OC2 CHEMBL4745679 Ki(app) 130.0 nM
CCc1c(C)c2c(c(O)c1C/C=C(\C)CN(C)CCP(=O)(O)O)C(=O)OC2 CHEMBL210909 IC50 132.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)N[C@@H](CCSC)C(=O)O)C(=O)OC2 CHEMBL3098175 Ki 134.0 nM
COc1cc2nc(-c3ccc(OC)c(N4CCN(C)CC4)c3)cc(O)c2cc1-c1cnco1 CHEMBL152931 IC50 140.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)O)C(=O)CC2 CHEMBL133972 IC50 140.0 nM
COc1cc(NC(=O)c2cc3ccccn3c2)ccc1-c1cnco1 CHEMBL95622 IC50 140.0 nM
COc1cc(Nc2ncc(-c3ccccc3C(=O)N(C)C)o2)ccc1-c1cnco1 CHEMBL66564 IC50 141.0 nM
NC(=O)c1csc([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)nc(-c6ccccc6)nc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)n1 CHEMBL264107 Ki 143.0 nM
COC(=O)[C@H](CCSC)NC(=O)CC/C(C)=C/Cc1c(O)c2c(c(C)c1OC)COC2=O CHEMBL3098174 Ki 147.0 nM
Cc1cccc(NC(=O)Nc2ccc3cncnc3c2)c1 CHEMBL26741 IC50 150.0 nM
COc1cc(Nc2nc(N)n(-c3ccccc3)n2)ccc1-c1cnco1 CHEMBL307547 IC50 150.0 nM
COc1cc2[nH]c3c(c2cc1-c1cnco1)CCCC(=O)C3 CHEMBL277187 IC50 150.0 nM
NC(=O)c1csc([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)nc(Nc6ccccc6)nc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)n1 CHEMBL441190 Ki 153.0 nM
COc1cc2nc(-c3cccc(C(=O)O)c3)cc(O)c2cc1-c1cnco1 CHEMBL151112 IC50 160.0 nM
COc1cc2nc(-c3cccc(S(C)(=O)=O)c3)cc(O)c2cc1-c1cnco1 CHEMBL358383 IC50 160.0 nM
COc1cc(Nc2nc(-c3ccccc3)nc(N3CCN(C=O)CC3)n2)ccc1-c1cnco1 CHEMBL65957 IC50 160.0 nM
CNc1nc(Nc2ccc(-c3cnco3)c(OC)c2)nc(N2CCOCC2)n1 CHEMBL305214 IC50 160.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)OC2 CHEMBL2437254 Ki 163.0 nM
COc1c(C)c2c(c(O)c1CCOP(=O)(O)CP(=O)(O)OC[C@H]1O[C@@H](n3cnc4c(N)cccc43)[C@H](O)[C@@H]1O)C(=O)OC2 CHEMBL3098178 Ki 165.0 nM
COc1c(C)c2c(c(O)c1CCNS(=O)(=O)CS(=O)(=O)NC[C@@H]1O[C@H](n3cnc4c(N)ncnc43)[C@@H](O)[C@H]1O)C(=O)OC2 CHEMBL1683748 Ki 167.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CP(=O)(O)O)C(=O)OC2 CHEMBL427225 IC50 168.0 nM
NC(=O)c1csc([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)nc(NCc6ccccc6)nc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)n1 CHEMBL265870 Ki 169.0 nM
CNc1nc(Nc2ccc(-c3cnco3)c(OC)c2)nc(-c2ccc(C)cc2)n1 CHEMBL67703 IC50 170.0 nM
COc1cc(NC(=O)c2cc3ccccc3s2)ccc1-c1cnco1 CHEMBL321581 IC50 170.0 nM
COc1c(C)c2c(c(O)c1CCNS(=O)(=O)CS(=O)(=O)NC[C@H]1O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]1O)C(=O)OC2 CHEMBL446927 Ki 170.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)N[C@H](Cc1c[nH]c3ccccc13)C(=O)O)C(=O)OC2 CHEMBL3098168 Ki 174.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)N[C@H](C(=O)O)C(C)C)C(=O)OC2 CHEMBL2437272 Ki 175.0 nM
COc1cc2nc(Cc3ccccc3)cc(O)c2cc1-c1cnco1 CHEMBL153759 IC50 180.0 nM
Cn1cc(C#N)c2ccc(Nc3ncc(-c4cccc(CN)c4)o3)cc21 CHEMBL120656 IC50 180.0 nM
Cn1cc(C#N)c2ccc(Nc3ncc(-c4ccc(CNC(=O)C(C)(C)C)cc4)o3)cc21 CHEMBL119407 IC50 180.0 nM
COc1cc(N/C(=N/c2cccc(CNC(=O)NCC3CCCO3)c2)NC#N)ccc1-c1cnco1 CHEMBL101270 IC50 180.0 nM
C#Cc1nc(N)c2ncn([C@@H]3O[C@H](CNS(=O)(=O)CS(=O)(=O)NCCc4c(O)c5c(c(C)c4OC)COC5=O)[C@@H](O)[C@H]3O)c2n1 CHEMBL389392 Ki 180.0 nM
COc1c(C)c(C)c([N+](=O)[O-])c(O)c1C/C=C(\C)CCC(=O)O CHEMBL134206 IC50 184.0 nM
COc1c(C)c2c(c(O)c1CCOP(=O)(O)CP(=O)(O)OC[C@H]1O[C@@H](n3c(Br)nc4c(N)ncnc43)[C@H](O)[C@@H]1O)C(=O)OC2 CHEMBL3098179 Ki 186.0 nM
COc1cc2[nH]c(=O)n(CCc3ccncc3)c(=O)c2cc1-c1cnco1 CHEMBL179230 IC50 188.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)NC[C@H]1O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]1O)C(=O)OC2 CHEMBL3098166 Ki 188.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)N[C@@H](Cc1ccccc1)C(=O)NC[C@H]1O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]1O)C(=O)OC2 CHEMBL3098186 Ki 188.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)NCC(=O)NC[C@H]1O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]1O)C(=O)OC2 CHEMBL3098185 Ki 188.0 nM
COc1cc(Nc2n[nH]c(-c3ccccc3)n2)ccc1-c1cnco1 CHEMBL104240 IC50 190.0 nM
COc1cc(Nc2nc(-c3ccccc3)nc(N3CCOCC3)n2)ccc1-c1cnco1 CHEMBL432528 IC50 190.0 nM
COc1cc(Nc2ncc(-c3ccccc3)o2)ccc1-c1ncco1 CHEMBL65737 IC50 190.0 nM
COc1cc2c(cc1-c1cnco1)C(=O)N(C)C(C)(C)N2 CHEMBL370650 IC50 192.0 nM
Cc1cccc(NC(=O)Nc2ccc3c(-c4cnco4)c[nH]c3c2)c1 CHEMBL112444 IC50 200.0 nM
COc1cc2nc(N(C)C)cc(O)c2cc1-c1cnco1 CHEMBL346396 IC50 200.0 nM
Cn1cc(C#N)c2ccc(Nc3ncc(-c4cccc(NC(=O)c5ccccc5)c4)o3)cc21 CHEMBL327031 IC50 200.0 nM
COc1cc(NC(=O)/C=C/c2cccc(F)c2)ccc1-c1cnco1 CHEMBL421203 IC50 200.0 nM
COc1c(C)c2c(c(O)c1CCn1cc(COC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)nn1)C(=O)OC2 CHEMBL1170850 Ki 200.0 nM
COc1cc(NC(=O)C(=O)Nc2cccc(/C=C/C(=O)NO)c2)ccc1-c1cnco1 CHEMBL1215313 Ki(app) 200.0 nM
Cc1ccc(-c2cnc(Nc3ccc4c(-c5cnco5)c[nH]c4c3)o2)cc1 CHEMBL324781 IC50 205.0 nM
CN(C)CCOC(=O)NCc1cccc(-c2cnc(Nc3ccc4c(C#N)cn(C)c4c3)o2)c1 CHEMBL118115 IC50 210.0 nM
COc1cc2nc(-c3ccccc3)cc(O)c2cc1-c1cocn1 CHEMBL65738 IC50 210.0 nM
COc1cc(NC(=O)/C=C/c2ccc(C)cc2)ccc1-c1cnco1 CHEMBL95865 IC50 210.0 nM
COc1cc(NC(=O)c2cc3ccccc3o2)ccc1-c1cnco1 CHEMBL95962 IC50 210.0 nM
COc1cc(NC(=O)/C=C/c2cccnc2)ccc1-c1cnco1 CHEMBL318066 IC50 210.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)OC2 CHEMBL3098171 Ki 215.0 nM
CNc1cc(O)c2cc(-c3cnco3)c(OC)cc2n1 CHEMBL357069 IC50 220.0 nM
COc1cc2[nH]c(Cc3ccccc3)c(C#N)c2cc1-c1cnco1 CHEMBL23108 IC50 220.0 nM
Cc1[nH]c2cc(NS(=O)(=O)c3ccccc3)ccc2c1-c1ccncc1 CHEMBL379524 IC50 222.0 nM
COc1cc2[nH]c(-c3ccccc3)c(C=O)c2cc1-c1cnco1 CHEMBL23883 IC50 230.0 nM
Cc1ccc(NC(=O)Nc2ccc3c(C#N)cn(C)c3c2)cc1 CHEMBL323943 IC50 230.0 nM
COc1cc(NC(=O)/C=C/c2ccc(Cl)cc2)ccc1-c1cnco1 CHEMBL100205 IC50 230.0 nM
COc1cc(NC(=O)Nc2ccc(/C=C/C(=O)NO)cc2)ccc1C#N CHEMBL1215245 Ki(app) 230.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)Nc1ccc(Cl)c(C(F)(F)F)c1)C(=O)OC2 CHEMBL4754678 Ki(app) 230.0 nM
C/C(=C\Cc1c(O)c2c(c(C)c1C(N)=O)COC2=O)CCC(=O)O CHEMBL133974 IC50 231.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)OC[C@@H]1O[C@H](n3cnc4c(N)ncnc43)[C@@H](O)[C@H]1O)C(=O)OC2 CHEMBL3098181 Ki 231.0 nM
COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC/C(C)=C/Cc1c(O)c2c(c(C)c1OC)COC2=O CHEMBL3098164 Ki 233.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)O)C(=O)OC2 CHEMBL3098165 Ki 235.0 nM
Cn1cc(C#N)c2ccc(Nc3ncc(-c4cccc(CNC(=O)OCCC#N)c4)o3)cc21 CHEMBL118260 IC50 240.0 nM
COc1cc(N/C(=N/c2ccccc2)NC#N)ccc1-c1cnco1 CHEMBL60730 IC50 240.0 nM
COc1cc(N/C(=N/c2cccc(C)c2)NC#N)ccc1-c1cnco1 CHEMBL98740 IC50 240.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)O)C(=O)NC2 CHEMBL133718 IC50 244.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)COCP(=O)(O)O)C(=O)OC2 CHEMBL378089 IC50 246.0 nM
Cc1ccc(NC(=O)Nc2ccc3cnccc3c2)cc1 CHEMBL29927 IC50 247.0 nM
COc1cc(Nc2nc(NCC(=O)O)nc(-c3ccccc3)n2)ccc1-c1cnco1 CHEMBL68170 IC50 250.0 nM
COc1c(C)c2c(c(O)c1CCOP(=O)(O)CP(=O)(O)OC[C@H]1O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]1O)C(=O)OC2 CHEMBL410744 Ki 250.0 nM
COc1cc(NC(=O)Nc2ccc(/C=C/C(=O)NO)cc2)ccc1-c1cnco1 CHEMBL1215243 Ki(app) 250.0 nM
COc1c(C)c2c(c(O)c1CC=C(C)C)C(=O)OC2 CHEMBL209723 IC50 254.0 nM
NC(=O)c1csc([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)nc(NCCc6ccccc6)nc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)n1 CHEMBL414564 Ki 255.0 nM
Cn1cc(C#N)c2ccc(Nc3ncc(-c4ccc(CN)cc4)o3)cc21 CHEMBL118664 IC50 260.0 nM
Cn1cc(C#N)c2ccc(Nc3ncc(-c4cccc(CNC(=O)OC5CCOC5)c4)o3)cc21 CHEMBL333662 IC50 260.0 nM
COc1cc(NC(=O)c2ccc(C)c(C)c2)ccc1-c1cnco1 CHEMBL414224 IC50 260.0 nM
CC(=O)OCC(=O)N(C)c1ccccc1-c1cnc(Nc2ccc3c(C#N)cn(C)c3c2)o1 CHEMBL116596 IC50 266.0 nM
COc1cc(Nc2nc(-c3ccccc3)nc(N(C)C)n2)ccc1-c1cnco1 CHEMBL68220 IC50 270.0 nM
NC(=O)c1c[se]c([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c1 CHEMBL3144003 Ki 270.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)Nc1ccc(F)cc1)C(=O)OC2 CHEMBL4794916 Ki(app) 270.0 nM
COC/C(C)=C/Cc1c(O)c2c(c(C)c1OC)COC2=O CHEMBL378113 IC50 273.0 nM
Cn1cc(C#N)c2ccc(Nc3ncc(-c4ccccc4CN)o3)cc21 CHEMBL333483 IC50 280.0 nM
COc1cc(N/C(=N/c2cccc(CO)c2)NC#N)ccc1-c1cnco1 CHEMBL99625 IC50 280.0 nM
C/C(=C\Cc1c(C)c(C)c(C)c([N+](=O)[O-])c1O)CCC(=O)O CHEMBL134954 IC50 289.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CP(=O)(OC)OC)C(=O)OC2 CHEMBL208748 IC50 289.0 nM
COc1c(C)c2c(c(O)c1C/C=C(/C)CCCOP(=O)(O)CP(=O)(O)OC[C@@H]1OC(n3cnc4c(N)ncnc43)[C@@H](O)[C@H]1O)C(=O)OC2 CHEMBL608195 Ki 290.0 nM
COC[C@@H]1CCCN1c1nc(Nc2ccc(-c3cnco3)c(OC)c2)nc(-c2ccccc2)n1 CHEMBL68146 IC50 290.0 nM
COc1cc2[nH]c3c(c2cc1-c1cnco1)CC(=O)CC3 CHEMBL23127 IC50 290.0 nM
COc1cc(NC(=O)Nc2cccc(C)c2)ccc1C#N CHEMBL116208 IC50 290.0 nM
COc1c(C)c2c(c(O)c1C/C=C/C(=O)Nc1ccc(Cl)cc1)C(=O)OC2 CHEMBL4744226 Ki(app) 290.0 nM
COc1cc2[nH]c(=O)n(CCN3CCOCC3)c(=O)c2cc1-c1cnco1 CHEMBL444085 IC50 297.0 nM
NC(=O)c1csc([C@@H]2O[C@H](COP(=O)(O)C(F)(F)P(=O)(O)OC[C@@H]3O[C@H](n4cnc5c(N)ncnc54)[C@@H](O)[C@H]3O)[C@@H](O)[C@H]2O)n1 CHEMBL3144028 Ki 300.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCCOP(=O)(O)CP(=O)(O)OC[C@@H]1OC(n3cnc4c(N)ncnc43)[C@@H](O)[C@H]1O)C(=O)OC2 CHEMBL610421 Ki 300.0 nM
COc1cc(Nc2nc(-c3ccccc3)cs2)ccc1-c1cnco1 CHEMBL104739 IC50 300.0 nM
COc1cc2nccc(O)c2cc1-c1cnco1 CHEMBL359161 IC50 300.0 nM
COc1cc(NC(=O)/C=C/c2cccc(Cl)c2)ccc1-c1cnco1 CHEMBL330428 IC50 300.0 nM
COc1cc2c(cc1-c1cnco1)C(=O)N(CCc1ccncc1)C(C)(C)N2 CHEMBL198791 IC50 300.0 nM
CNc1nc(Nc2ccc(-c3cnco3)c(OC)c2)nc(-c2ccccc2C)n1 CHEMBL65958 IC50 310.0 nM
CCc1cc(Nc2ncc(-c3ccccc3N(C)C(=O)CN3CCOCC3)o2)ccc1-c1cnco1 CHEMBL62747 IC50 310.0 nM
COc1c(C)c2c(c(O)c1CCNS(=O)(=O)CS(=O)(=O)NC[C@H]1O[C@@H](n3cnc4c(N)nc(-c5ccccc5)nc43)[C@H](O)[C@@H]1O)C(=O)OC2 CHEMBL510826 Ki 310.0 nM
COc1cc(N/C(=N/c2cccnc2)NC#N)ccc1-c1cnco1 CHEMBL101822 IC50 320.0 nM
NC(=O)c1csc([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c1 CHEMBL3144004 Ki 320.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)NCC(=O)O)C(=O)OC2 CHEMBL2437269 Ki 321.0 nM
COc1cc2c(cc1-c1cnco1)C(=O)N(C)C1(CCCC1)N2 CHEMBL199128 IC50 328.0 nM
COc1cc(Nc2nnc(-c3ccccc3)s2)ccc1-c1cnco1 CHEMBL104282 IC50 330.0 nM
COc1cc(Nc2nc(-c3ccccc3)nc(N3CCN(C)CC3)n2)ccc1-c1cnco1 CHEMBL69527 IC50 330.0 nM
COc1cc(NC(=N)NC#N)ccc1-c1cnco1 CHEMBL98393 IC50 330.0 nM
COc1cc(NC(=O)c2ccc3c(c2)OCO3)ccc1-c1cnco1 CHEMBL321972 IC50 330.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)N[C@@H]1CO1)C(=O)OC2 CHEMBL2418585 IC50 330.0 nM
COc1cc(N/C(=N/c2ccccn2)NC#N)ccc1-c1cnco1 CHEMBL98322 IC50 340.0 nM
COc1cc(N/C(=N/c2cccc(CNC(=O)O[C@H]3CCOC3)c2)NC#N)ccc1-c1cnco1 CHEMBL101463 IC50 340.0 nM
COc1cc(NC(=O)NCc2cccc(/C=C/C(=O)NO)c2)ccc1-c1cnco1 CHEMBL1215174 Ki(app) 340.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)Nc1ccc(Cl)c(Cl)c1)C(=O)OC2 CHEMBL4786474 Ki(app) 340.0 nM
Cc1[nH]c2ccccc2c1-c1ccncc1 CHEMBL207501 IC50 343.0 nM
COc1cc(NC(=O)CC/C(C)=C/Cc2c(O)c3c(c(C)c2OC)COC3=O)ccc1Cl CHEMBL4790325 Ki(app) 350.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)Nc1ccc(C#N)cc1)C(=O)OC2 CHEMBL4759843 Ki(app) 350.0 nM
COc1cc2[nH]c(Cc3ccccc3)c(C=O)c2cc1-c1cnco1 CHEMBL280431 IC50 360.0 nM
O=C(COc1ccc(C(=O)/C=C/c2c(F)cccc2F)cc1)Nc1ccc2c(c1)COC2=O CHEMBL4278234 IC50 360.0 nM
COc1cccc(/C=C/C(=O)c2ccc(OCC(=O)Nc3ccc4c(c3)COC4=O)cc2)c1 CHEMBL4293371 IC50 360.0 nM
O=S(=O)(Nc1ccc2c(-c3ccncc3)c[nH]c2c1)c1ccccc1 CHEMBL380132 IC50 364.0 nM
COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CC/C(C)=C/Cc1c(O)c2c(c(C)c1OC)COC2=O CHEMBL3098170 Ki 364.0 nM
COC(=O)[C@@H]1C[C@]2(CN1C(=O)OC(C)(C)C)Nc1cc(OC)c(-c3cnco3)cc1C(=O)N2C CHEMBL198524 IC50 369.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)COP(=O)(O)CP(=O)(O)OC[C@@H]1O[C@H](n3cnc4c(N)ncnc43)[C@@H](O)[C@H]1O)C(=O)OC2 CHEMBL2311206 Ki 380.0 nM
COc1cc(N/C(=N/c2cccc(OCCOc3ccccc3)c2)NC#N)ccc1-c1cnco1 CHEMBL99278 IC50 380.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)COP(=O)(O)CP(=O)(O)OC[C@H]1O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]1O)C(=O)OC2 CHEMBL1170847 Ki(app) 380.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)N[C@H]1CO1)C(=O)OC2 CHEMBL2418586 IC50 387.0 nM
CNc1nc(Nc2ccc(-c3cnco3)c(OC)c2)nc(N2CCC[C@H]2COC)n1 CHEMBL422584 IC50 390.0 nM
COc1cc2c(cc1-c1cnco1)C(=O)N(C)C1(CCN(C(=O)Nc3ccccc3)C1)N2 CHEMBL372187 IC50 393.0 nM
O=C(NCc1ccccc1)Nc1ccc2cnccc2c1 CHEMBL29926 IC50 400.0 nM
COc1c(C)c2c(c(O)c1CCOP(=O)(O)CP(=O)(O)O)C(=O)OC2 CHEMBL162782 Ki 400.0 nM
COc1cc(Nc2ncc(-c3ccccc3)o2)ccc1C#N CHEMBL117408 IC50 400.0 nM
COc1cc(NC(=O)CC(=O)Nc2ccccc2)ccc1-c1cnco1 CHEMBL24737 IC50 400.0 nM
COc1cc(Nc2nc(C)c(Cc3cccc(Cl)c3)s2)ccc1-c1cnco1 CHEMBL1915558 IC50 400.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)Nc1ccc(C(F)(F)F)cc1)C(=O)OC2 CHEMBL4792331 Ki(app) 400.0 nM
Brc1ccc2c(-c3ccncc3)c[nH]c2c1 CHEMBL206257 IC50 408.0 nM
COc1cc(Nc2nc(NCc3ccccc3)nc(-c3ccccc3)n2)ccc1-c1cnco1 CHEMBL308241 IC50 410.0 nM
COc1cc(Nc2ncc(-c3ccccc3)o2)ccc1-n1cncn1 CHEMBL62377 IC50 410.0 nM
CCc1c2c(c(O)c(C/C=C(\C)CCC(=O)O)c1OC)C(=O)OC2 CHEMBL132181 IC50 410.0 nM
COc1cc(NC(=O)/C=C/c2ccccc2F)ccc1-c1cnco1 CHEMBL95418 IC50 410.0 nM
Cc1[nH]c2cc(N)ccc2c1-c1ccncc1 CHEMBL207502 IC50 419.0 nM
Cn1cc(C#N)c2ccc(Nc3ncc(-c4ccccc4CNC(=O)OCCC#N)o3)cc21 CHEMBL118983 IC50 420.0 nM
Cn1cc(C#N)c2ccc(Nc3ncc(-c4ccccc4CNC(=O)OC4CCOC4)o3)cc21 CHEMBL118384 IC50 420.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)O)C(=O)OC2C CHEMBL132258 IC50 420.0 nM
O=C(COc1cccc(C(=O)/C=C/c2ccccc2)c1)Nc1ccc2c(c1)COC2=O CHEMBL4279728 IC50 430.0 nM
C[C@H](NC(=O)c1ccc2c(=O)c3ccccc3[nH]c2c1)c1ccccc1 CHEMBL231148 IC50 431.0 nM
COc1c(C)c(C)c(Cl)c(F)c1C/C=C(\C)CCC(=O)O CHEMBL337471 IC50 437.0 nM
COC(=O)[C@H](Cc1ccccc1)NC(=O)CC/C(C)=C/Cc1c(O)c2c(c(C)c1OC)COC2=O CHEMBL2437265 Ki 437.0 nM
COC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC/C(C)=C/Cc1c(O)c2c(c(C)c1OC)COC2=O CHEMBL3098167 Ki 438.0 nM
O=P(O)(O)OC[C@@H]1OC(n2cnc3c(O)nc(C(O)O)nc32)[C@@H](O)[C@H]1O CHEMBL610230 IC50 440.0 nM
Cc1ccccc1-c1cnc(Nc2ccc3c(C#N)cn(C)c3c2)o1 CHEMBL119114 IC50 440.0 nM
COc1cc(NC(=O)CC(=O)Nc2cccc(C)c2)ccc1-c1cnco1 CHEMBL25689 IC50 440.0 nM
CCc1nc(N)c2ncn([C@@H]3O[C@H](CNS(=O)(=O)CS(=O)(=O)NCCc4c(O)c5c(c(C)c4OC)COC5=O)[C@@H](O)[C@H]3O)c2n1 CHEMBL444916 Ki 440.0 nM
c1ccc(-c2ccc3c(-c4ccncc4)c[nH]c3c2)cc1 CHEMBL207621 IC50 456.0 nM
COc1c(C)c2c(c(O)c1CC(=O)Nc1ccc(Cl)cc1)C(=O)OC2 CHEMBL4795214 Ki(app) 460.0 nM
COc1c(C)c(C)c(Br)c(N)c1C/C=C(\C)CCC(=O)O CHEMBL444599 IC50 462.0 nM
COc1c(C)c(C)c([N+](=O)[O-])c(N)c1C/C=C(\C)CCC(=O)O CHEMBL135411 IC50 465.0 nM
COc1c(C)c2c(c(O)c1CCOP(=O)(O)CP(=O)(O)OCCc1c(O)c3c(c(C)c1OC)COC3=O)C(=O)OC2 CHEMBL348359 Ki 470.0 nM
COC(=O)CNC(=O)CC/C(C)=C/Cc1c(O)c2c(c(C)c1OC)COC2=O CHEMBL2437258 Ki 487.0 nM
COc1c(C)c(C)c(Cl)c(N)c1C/C=C(\C)CCC(=O)O CHEMBL132674 IC50 489.0 nM
Cc1cccc(-c2cnc(Nc3ccc4c(C#N)cn(C)c4c3)o2)c1 CHEMBL118613 IC50 490.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CN(CCP(=O)(O)O)S(C)(=O)=O)C(=O)OC2 CHEMBL212199 IC50 498.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CNCCP(=O)(O)O)C(=O)OC2 CHEMBL212170 IC50 499.0 nM
COc1cc2[nH]c(-c3ccccc3)cc2cc1-c1cnco1 CHEMBL23590 IC50 500.0 nM
COc1cc2[nH]c(-c3csc4ccccc34)cc2cc1-c1cnco1 CHEMBL277190 IC50 500.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3ocnc3C)cc2)c1 CHEMBL302224 IC50 500.0 nM
COc1c(C)c2c(c(O)c1C/C=C(C)/C=C/P(=O)(O)O)C(=O)OC2 CHEMBL384908 IC50 506.0 nM
COc1cc2c(c(O)c1C/C=C(\C)CCC(=O)O)C(=O)OC2 CHEMBL334760 IC50 515.0 nM
Nc1cccc2c(-c3ccncc3)c[nH]c12 CHEMBL207262 IC50 524.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)N1CCC[C@H]1C(=O)O)C(=O)OC2 CHEMBL3098176 Ki 524.0 nM
COc1cc2c(cc1-c1cnco1)C(=O)N(C)C1(CCOCC1)N2 CHEMBL198897 IC50 526.0 nM
COc1c(C)c(C)c(C#N)c(O)c1C/C=C(\C)CCC(=O)O CHEMBL131793 IC50 534.0 nM
COc1c(C/C=C(\C)CCC(=O)O)cc(Cl)c(C)c1C CHEMBL134953 IC50 537.0 nM
COc1cc(NC(=O)c2cc(C)c(C)o2)ccc1-c1cnco1 CHEMBL100929 IC50 540.0 nM
COc1c(C)c2c(c(O)c1CCC(C)CCC(=O)NO)C(=O)OC2 CHEMBL238905 Ki 540.0 nM
Nc1ccc2cnccc2c1Br CHEMBL27011 IC50 550.0 nM
COc1c(C)c2c(c(O)c1C[C@@H]1C[C@@]1(C)CCC(=O)Nc1ccc(Cl)c(C(F)(F)F)c1)C(=O)OC2 CHEMBL4762562 Ki(app) 550.0 nM
COc1c(C)c(C)c(Cl)c(Cl)c1C/C=C(\C)CCC(=O)O CHEMBL135055 IC50 557.0 nM
O=C(COc1ccc(/C=C/C(=O)c2ccc(F)cc2)cc1)Nc1ccc2c(c1)COC2=O CHEMBL4292222 IC50 570.0 nM
CCOC(=O)c1ccc2c(-c3ccncc3)c[nH]c2c1 CHEMBL208261 IC50 586.0 nM
COc1cc(NC(=O)/C=C/c2cccc(C)c2)ccc1-c1cnco1 CHEMBL320847 IC50 590.0 nM
COc1c(C)c(C)c(I)c(O)c1C/C=C(\C)CCC(=O)O CHEMBL135153 IC50 592.0 nM
COc1cc2[nH]c(Cc3ccccc3)cc2cc1-c1cnco1 CHEMBL281635 IC50 600.0 nM
CNc1nc(NC)nc(Nc2ccc(-c3cnco3)c(OC)c2)n1 CHEMBL67322 IC50 620.0 nM
C/C(=C\Cc1c(C)c(C)c(C)c(Br)c1O)CCC(=O)O CHEMBL134157 IC50 620.0 nM
Cn1cc(C#N)c2ccc(NC(=O)Nc3ccccc3)cc21 CHEMBL333482 IC50 630.0 nM
COc1cc(NC(=O)/C=C/c2c[nH]c3ccccc23)ccc1-c1cnco1 CHEMBL99044 IC50 630.0 nM
COc1cc(NC(=O)c2ccccc2)ccc1-c1cnco1 CHEMBL99571 IC50 630.0 nM
COc1cc(NC(=O)c2ccc3[nH]ccc3c2)ccc1-c1cnco1 CHEMBL99874 IC50 630.0 nM
Nc1ccc2c(-c3ccncc3)c[nH]c2c1 CHEMBL207612 IC50 637.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cnco3)cc2)c1 CHEMBL62232 IC50 640.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)O)C(=O)OCC2 CHEMBL422804 IC50 644.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)Nc1ccccc1N)C(=O)OC2 CHEMBL239105 Ki 650.0 nM
CON/C(=N\c1ccc(-c2cnco2)c(OC)c1)Nc1cccc(C)c1 CHEMBL98904 IC50 660.0 nM
COc1ccc(/C=C/C(=O)c2ccc(OCC(=O)Nc3ccc4c(c3)COC4=O)cc2)cc1 CHEMBL4287819 IC50 660.0 nM
Cc1cccc(NC(=O)Nc2ccc3c(C#N)cn(C)c3c2)c1 CHEMBL118899 IC50 670.0 nM
COc1c(C)c(C)c(C#N)c(Cl)c1C/C=C(\C)CCC(=O)O CHEMBL134052 IC50 681.0 nM
NC(=O)c1csc([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@@H]3O[C@H](n4cnc5c(N)ncnc54)[C@@H](O)[C@H]3F)[C@@H](O)[C@H]2O)n1 CHEMBL3144026 IC50 700.0 nM
CNc1nc(Nc2ccc(-c3cnco3)c(OC)c2)nc(N2CCC[C@@H]2CO)n1 CHEMBL66176 IC50 720.0 nM
O=C(Nc1ccccc1)Nc1ccc2cnccc2c1 CHEMBL27529 IC50 740.0 nM
O=C(Nc1ccccc1)Nc1ccc2cnccc2c1Br CHEMBL26258 IC50 740.0 nM
CCOC(=O)N/C(=N\c1ccc(-c2cnco2)c(OC)c1)Nc1cccc(C)c1 CHEMBL317497 IC50 740.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CN(C=O)CCP(=O)(O)O)C(=O)OC2 CHEMBL379098 IC50 749.0 nM
COc1c(C)c2c(c(O)c1CCOP(=O)(O)CP(=O)(O)OC[C@H]1O[C@@H](n3cnc4c([N+](=O)[O-])cccc43)[C@H](O)[C@@H]1O)C(=O)OC2 CHEMBL3098177 Ki 749.0 nM
COc1cc(Nc2cnc(-c3ccccc3)s2)ccc1-c1cnco1 CHEMBL104710 IC50 760.0 nM
C/C(=C\Cc1c(C)c(C)c(C)c(Br)c1N)CCC(=O)O CHEMBL114426 IC50 763.0 nM
COc1c(C)c2c(c(O)c1CCOP(=O)(O)CCP(=O)(O)OCCc1c(O)c3c(c(C)c1OC)COC3=O)C(=O)OC2 CHEMBL1683747 Ki 770.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CN(CCP(=O)(O)O)C(C)=O)C(=O)OC2 CHEMBL210515 IC50 785.0 nM
COc1c(C)c2c(c(O)c1C/C=C(\C)CCCO)C(=O)OC2 CHEMBL157617 IC50 790.0 nM
O=C(COc1ccc(C(=O)/C=C/c2ccccc2)cc1)Nc1ccc2c(c1)COC2=O CHEMBL4286567 IC50 790.0 nM
COc1c(C/C=C(\C)CCC(=O)O)cc(Br)c(C)c1C CHEMBL134156 IC50 795.0 nM
COc1cc(NC(=N)NC(=O)c2ccccc2)ccc1-c1cnco1 CHEMBL329714 IC50 800.0 nM
NC(=O)c1csc([C@@H]2O[C@H](COP(=O)(O)C(F)(F)P(=O)(O)OC[C@@H]3O[C@H](n4cnc5c(N)ncnc54)[C@H](F)[C@H]3O)[C@@H](O)[C@H]2O)n1 CHEMBL3144061 IC50 800.0 nM
NC(=O)c1cccc([C@@H]2O[C@H](COP(=O)(O)CP(=O)(O)OC[C@@H]3O[C@H](n4cnc5c(N)ncnc54)[C@@H](O)[C@H]3O)[C@@H](O)[C@H]2O)c1 CHEMBL3144007 IC50 800.0 nM
COc1c(C)c2c(c(O)c1CCCC(=O)Nc1ccc(Cl)cc1)C(=O)OC2 CHEMBL4760324 Ki(app) 800.0 nM
COc1cc(NC(=O)c2cccs2)ccc1-c1cnco1 CHEMBL97096 IC50 810.0 nM
C=Cc1c(N)ccc2cnccc12 CHEMBL26155 IC50 820.0 nM
COc1cc2[nH]c(=S)n(CC(C)(C)C)c(=O)c2cc1-c1cnco1 CHEMBL178520 IC50 821.0 nM
COc1cc(NC(=O)c2ccc(-c3ccccn3)s2)ccc1-c1cnco1 CHEMBL95976 IC50 870.0 nM
COc1c(C)c2c(c(O)c1C[C@H]1C[C@]1(C)CCC(=O)Nc1ccc(Cl)c(C(F)(F)F)c1)C(=O)OC2 CHEMBL4787083 Ki(app) 870.0 nM
COc1cc(NC(=O)c2cccn2C)ccc1-c1cnco1 CHEMBL95382 IC50 890.0 nM
COC(=O)[C@@H]1C[C@@]2(CN1C(=O)OC(C)(C)C)Nc1cc(OC)c(-c3cnco3)cc1C(=O)N2C CHEMBL197532 IC50 948.0 nM
NC(=O)c1cccc(C2OC(COP(=O)(O)CP(=O)(O)OC[C@@H]3OC(n4cnc5c(N)ncnc54)[C@@H](O)[C@H]3O)[C@@H](O)[C@H]2O)c1 CHEMBL608194 Ki 950.0 nM
COc1c(C)c(C)c(C)c(O)c1C/C=C(\C)CCC(=O)O CHEMBL132428 IC50 959.0 nM
COc1ccccc1/C=C\C(=O)Nc1ccc(-c2cnco2)c(OC)c1 CHEMBL99233 IC50 960.0 nM
COC(=O)[C@@H](NC(=O)CC/C(C)=C/Cc1c(O)c2c(c(C)c1OC)COC2=O)C(C)C CHEMBL2437261 Ki 967.0 nM
COc1cc(NC(=O)Cc2ccccc2)ccc1-c1cnco1 CHEMBL419143 IC50 970.0 nM
COc1c(Br)c2c(c(O)c1C/C=C(\C)CCC(=O)O)C(=O)OC2 CHEMBL134011 IC50 975.0 nM
C=Cc1nc(O)c2ncn(C3O[C@@H](COP(=O)(O)O)[C@H](O)[C@@H]3O)c2n1 CHEMBL607644 IC50 1000.0 nM