CN1CCC(n2cc(Nc3nc(OC4(C)CC4)c4nc(-c5cncnc5)ccc4n3)cn2)CC1 CHEMBL5283628 IC50 2.0 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3cc(F)cc(F)c3)[nH]c3ccc(CN4CCC(C(C)(C)O)CC4)cc32)CC1 CHEMBL2172315 Kd 5.6 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3ccc(CN4CCC(C(C)(C)O)CC4)cc32)CC1 CHEMBL2172308 Kd 5.7 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 6.1 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 9.0 nM
C=CC(=O)Nc1cccc(C(=O)Nc2ccc(NC(=O)c3cccc(-c4ccn[nH]4)n3)cc2)c1 CHEMBL4782804 IC50 9.0 nM
COc1cc(N2CCOCC2)ccc1NC(=O)c1cccc(-c2ccn[nH]2)n1 CHEMBL256713 IC50 9.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 9.7 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 10.0 nM
O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1-c1ccc(CCO)cc1)c1cccc(C(F)(F)F)c1 CHEMBL3736465 Ki 12.0 nM
COc1cc(C=C(C#N)c2nc3ccccc3[nH]2)c(Br)cc1O CHEMBL1994241 pKi 12.59 nM
COc1cc(C=C(C#N)c2nc3cc(C)ccc3[nH]2)c(Br)cc1O CHEMBL2000345 pKi 12.59 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 14.0 nM
CCc1cc2c(cc1-c1cnn(CC(=O)N(C)C)c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3735401 IC50 14.0 nM
CN(C)C/C=C/C(=O)Nc1cccc(C(=O)Nc2ccc(Nc3nccc(-c4cccnc4)n3)cc2)c1 CHEMBL3393607 IC50 14.2 nM
CCc1cc2c(cc1-c1cnn(CCCN(C)C)c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3746678 IC50 15.0 nM
CCCCn1c(NC(=O)c2cccc(C#N)c2)nc2cc(N(C)C(=O)C3CCCCC3)ccc21 CHEMBL1969301 pKi 15.85 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 16.0 nM
O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1[C@H]1CC[C@H](O)CC1)c1cccc([N+](=O)[O-])c1 CHEMBL3735673 Ki 18.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1 CHEMBL4550702 IC50 19.0 nM
O=C(Nc1nc2ccccc2n1CCCO)c1cccc([N+](=O)[O-])c1 CHEMBL210887 pKi 19.95 nM
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1973540 pKi 19.95 nM
CC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnn4ccc(C(C)C)c34)CC2)CC1 CHEMBL4278882 IC50 21.0 nM
COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cnn(C)c1 CHEMBL5176837 IC50 22.6 nM
c1nc(N[C@H]2CC[C@H](N3CCOCC3)CC2)c2c(C3CCOCC3)c[nH]c2n1 CHEMBL4064608 IC50 23.0 nM
O=C(Nc1cc2sc(N3CCOCC3)nc2cc1N1CCC(CO)CC1)c1cnn2cccnc12 CHEMBL4474636 Ki 24.0 nM
C=CC(=O)Nc1cccc(C(=O)Nc2cccc(NC(=O)c3cccc(-c4ccn[nH]4)n3)c2)c1 CHEMBL4784448 IC50 25.0 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 25.12 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 26.0 nM
COC(=O)N1CCN([C@H]2CC[C@H](Nc3nc(Nc4cnn(C)c4)nc4ccc(CC#N)nc34)CC2)CC1 CHEMBL4582624 IC50 27.0 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(-c4ccccc4)c3n2)c1 CHEMBL1988163 pKi 31.62 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 31.62 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccccc1 CHEMBL1999931 pKi 31.62 nM
C1=N/C2=N/c3ccc(OCCN4CCCC4)c(c3)COC/C=C/COCc3cccc(c3)C(=C1)N2 CHEMBL2035187 IC50 39.5 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 39.81 nM
COC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnc4ccc(C#N)cc34)CC2)CC1 CHEMBL4455718 IC50 44.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 45.0 nM
C=CC(=O)Nc1ccc(C(=O)Nc2ccc(NC(=O)c3cccc(-c4ccn[nH]4)n3)cc2)cc1 CHEMBL4799481 IC50 47.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 48.0 nM
O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1[C@H]1CC[C@@H](CO)CC1)c1cccc([N+](=O)[O-])c1 CHEMBL3734854 Ki 48.0 nM
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL601719 Kd 49.0 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCCCC2)n1 CHEMBL2006439 pKi 50.12 nM
Clc1cc(-c2c[nH]c3ncccc23)cc(NCc2ccccc2)n1 CHEMBL1969588 pKi 50.12 nM
CCCCn1c(NC(=O)c2ccc(C#N)cc2)nc2cc(N(C)C(=O)C3CCCCC3)ccc21 CHEMBL484390 pKi 50.12 nM
CN(C)C/C=C/C(=O)Nc1cccc(C(=O)Nc2ccc(NC(=O)c3cccc(-c4ccn[nH]4)n3)cc2)c1 CHEMBL4790193 IC50 52.0 nM
NCC1CCN(c2ccc(Cl)cc2NC(=O)c2cnn3cc(O)cnc23)CC1 CHEMBL3353219 IC50 55.0 nM
C=CC(=O)Nc1ccc(C(=O)Nc2cccc(NC(=O)c3cccc(-c4ccn[nH]4)n3)c2)cc1 CHEMBL4786242 IC50 55.0 nM
COc1cc(N2CCC(OCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)ccc1NC(=O)c1cccc(-c2ccn[nH]2)n1 CHEMBL4798892 IC50 60.0 nM
COc1cc(F)ccc1-c1cc(Nc2cc(CS(C)(=O)=O)ccn2)ncc1F CHEMBL5087022 Kd 61.0 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 63.1 nM
Cc1cccc(Nc2nc(NC3CCCCC3N)cnc2C(N)=O)c1 CHEMBL1974328 pKi 63.1 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc2cc[nH]c12 CHEMBL3416026 Kd 67.0 nM
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 CHEMBL939 Kd 69.0 nM
O=C(Nc1cc2cccnc2cc1O[C@H]1CC[C@@H](O)CC1)c1csc2cncnc12 CHEMBL3967068 IC50 70.0 nM
CC1NC(=O)NC1CCCCCC(=O)NCCOCCOCCOCCNC(=O)CCN(C)C/C=C/C(=O)Nc1cccc(C(=O)Nc2ccc(NC(=O)c3cccc(-c4ccn[nH]4)n3)cc2)c1 CHEMBL4751092 IC50 70.0 nM
O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1[C@H]1CC[C@@H](CO)CC1)c1cccc(C(F)(F)F)c1 CHEMBL3736036 Ki 72.0 nM
CC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnn4ccc(C5CCOCC5)c34)CC2)CC1 CHEMBL4290222 IC50 72.0 nM
COc1cc(N2CCC(OCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)c3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)ccc1NC(=O)c1cccc(-c2ccn[nH]2)n1 CHEMBL4762381 IC50 72.0 nM
COc1cc(N2CCC(OCC(=O)N[C@H](C(=O)N3C[C@@H](O)C[C@H]3C(=O)N[C@@H](C)c3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)ccc1NC(=O)c1cccc(-c2ccn[nH]2)n1 CHEMBL5083561 IC50 79.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL244378 pKi 79.43 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 79.43 nM
O=C1NCCc2[nH]c(-c3ccncc3)cc21 CHEMBL225519 pKi 79.43 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 pKi 79.43 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 79.43 nM
COc1cc(N2CCN(CCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)ccc1NC(=O)c1cccc(-c2cc[nH]n2)n1 CHEMBL5075213 IC50 80.0 nM
CN(C)c1nc2cc(N3CCC(CO)CC3)c(NC(=O)c3cnn4cccnc34)cc2s1 CHEMBL4464832 Ki 95.0 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1Cl CHEMBL1965660 pKi 100.0 nM
Nc1ncc(-c2cc([N+](=O)[O-])ccc2F)cc1-c1ccc2c(c1)CCNC2=O CHEMBL4874241 % inhibition 110.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 120.0 nM
O=C(Nc1cc2cccnc2cc1OC1CCC(O)CC1)c1csc2cncnc12 CHEMBL3902455 IC50 123.0 nM
NC1CCC(Nc2nccc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1966628 pKi 125.89 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)cc1)CCN2 CHEMBL411903 pKi 125.89 nM
CCc1c(-c2ccc(C(C)(C)O)cc2)[nH]c2nccnc12 CHEMBL1976420 pKi 125.89 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc32)c1C CHEMBL1990885 pKi 125.89 nM
Cc1ccc(Nc2nc3ccc([N+](=O)[O-])cc3[nH]2)nc1 CHEMBL1992937 pKi 125.89 nM
O=C(Nc1cc(Cl)ccc1O[C@H]1CC[C@@H](O)CC1)c1csc2cncnc12 CHEMBL3941034 IC50 126.0 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1 CHEMBL3301610 Kd apparent 126.0 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 130.0 nM
CCn1c(C)c(-c2ccnc(Nc3cccc(OC)c3)n2)sc1=O CHEMBL1986263 pKi 158.49 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1F CHEMBL1981079 pKi 158.49 nM
NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(-c3ccncc3)ccc2c1=O CHEMBL340384 pKi 158.49 nM
CS(=O)(=O)N(Cc1ccc2[nH]c(=O)c3cccn3c2c1)C1CC1 CHEMBL1978448 pKi 158.49 nM
O=C(Nc1cc(Cl)ccc1OC1CCC(O)CC1)c1cnn2cc(O)cnc12 CHEMBL3939426 IC50 163.0 nM
O=C(Nc1cc2cccnc2cc1O[C@H]1CC[C@H](O)CC1)c1csc2cncnc12 CHEMBL3972673 IC50 168.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 Kd 170.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCCN4)cc2)no1 CHEMBL4793380 IC50 179.0 nM
O=C(Nc1cc2sc(N3CCOCC3)nc2cc1N1CCOCC1)c1cnn2cccnc12 CHEMBL4568867 Ki 190.0 nM
CC(Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL1825138 pKi 199.53 nM
COc1cc2ncccc2cc1NC(=O)c1cnn2cc(O)cnc12 CHEMBL3978719 IC50 200.0 nM
COc1cc2nc(NCCO)ccc2cc1NC(=O)c1csc2cncnc12 CHEMBL3904732 IC50 200.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 220.0 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 Kd 220.0 nM
CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 CHEMBL1173655 Kd 240.0 nM
CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 CHEMBL2105712 Kd 240.0 nM
O=C(Nc1cc2cccnc2cc1O[C@@H]1CC[C@@H](O)C1)c1csc2cncnc12 CHEMBL4108668 IC50 246.0 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 CHEMBL3301612 Kd apparent 247.0 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2C CHEMBL519697 pKi 251.19 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL1970903 pKi 251.19 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(F)c1 CHEMBL2003638 pKi 251.19 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(O)c2)n1 CHEMBL243088 pKi 251.19 nM
CCC(=O)Nc1cccc(C(=O)Nc2ccc(NC(=O)c3cccc(-c4ccn[nH]4)n3)cc2)c1 CHEMBL4781702 IC50 259.0 nM
N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL1789941 Kd 290.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 299.0 nM
O=C(Nc1nc2ccccc2n1CCN1CCOCC1)c1cccc([N+](=O)[O-])c1 CHEMBL379787 IC50 300.0 nM
COc1cc2ncccc2cc1NC(=O)c1csc2cnc(N(C)CCO)nc12 CHEMBL3924130 IC50 300.0 nM
CN(C)CC1CCN(c2ccc(Cl)cc2NC(=O)c2cnn3cc(O)cnc23)CC1 CHEMBL3969222 IC50 307.0 nM
Cc1cccc(-c2[nH]c(-c3ccnc(N)n3)cc2C(N)=O)c1C CHEMBL1964290 pKi 316.23 nM
Cc1n[nH]c2cnc(-c3cncc(OCC(N)Cc4cccc(C(F)(F)F)c4)c3)cc12 CHEMBL1998159 pKi 316.23 nM
Cc1c[nH]c2nccc(Oc3c(F)cc(Nc4cc(Cl)nc(N)n4)cc3F)c12 CHEMBL1971943 pKi 316.23 nM
CC(C)(C)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1970104 pKi 316.23 nM
Cc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1Nc1ccc(OCC(N)=O)cc1 CHEMBL1988838 pKi 316.23 nM
Brc1cnc2[nH]cc(-c3ccccc3)c2c1 CHEMBL1992634 pKi 316.23 nM
O=C(Nc1cc2oc(N3CCOCC3)nc2cc1N1CCC(CO)CC1)c1cnn2cccnc12 CHEMBL4515682 Ki 340.0 nM
CC(C)(CCO)Oc1cc2ncccc2cc1NC(=O)c1csc2cncnc12 CHEMBL3958152 IC50 364.0 nM
O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1-c1ccccc1)c1cccc([N+](=O)[O-])c1 CHEMBL3735719 Ki 374.0 nM
CNc1ncc2cc(-c3cc(NC(=O)NCCC(C)(C)C)c(F)cc3C)c(C)nc2n1 CHEMBL3577124 IC50 390.0 nM
CNC(=O)COc1ccc(Nc2nc(Nc3ccc(C)c(S(N)(=O)=O)c3)ncc2F)cc1 CHEMBL1978099 pKi 398.11 nM
Fc1cnc(Nc2ccccc2)nc1Nc1ccccc1 CHEMBL491758 pKi 398.11 nM
Cc1cc(O)ccc1-n1cc(C(N)=O)c(=O)c2ccc(-c3ccncc3)cc21 CHEMBL340921 pKi 398.11 nM
CC(C)(C)C(=O)Oc1ccc2c(c1)nc(NC(=O)c1cccc([N+](=O)[O-])c1)n2CCCO CHEMBL1236126 pKi 398.11 nM
O=C(Nc1cc2cccnc2cc1N1CCC(CO)CC1)c1cnn2cccnc12 CHEMBL4453861 Ki 400.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 441.0 nM
C=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1 CHEMBL31965 Kd 450.0 nM
NCC1CCN(c2cc(C(=O)Nc3ccccc3)ccc2NC(=O)c2cnn3cccnc23)CC1 CHEMBL3920056 IC50 450.0 nM
NCC1CCN(c2ccc(Cl)cc2NC(=O)c2cnn3cccnc23)CC1 CHEMBL3960537 IC50 463.0 nM
CN(C)c1ccc2cc(NC(=O)c3cnn4cccnc34)c(N3CCCCC3)cc2n1 CHEMBL4551768 Ki 500.0 nM
O=c1cc(-c2ccncc2)nc(NC2CCCCC2)[nH]1 CHEMBL1958401 pKi 501.19 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(Cc4ccccc4)c3n2)c1 CHEMBL1993424 pKi 501.19 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl CHEMBL458997 pKi 501.19 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 501.19 nM
O=C(NN=Cc1ccc(O)cc1O)Nc1cccc2nsnc12 CHEMBL1999811 pKi 501.19 nM
CCCCOc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1996817 pKi 501.19 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccc(Cl)c(Cl)c4)c3)cc12 CHEMBL1991063 pKi 501.19 nM
NCC1CCN(c2cc3ncccc3cc2NC(=O)c2cnn3cccnc23)CC1 CHEMBL3950656 Ki 510.0 nM
NCCCOc1cc2ncccc2cc1NC(=O)c1csc2cncnc12 CHEMBL3983893 IC50 529.0 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1 CHEMBL428690 Kd 540.0 nM
COc1cc2ncccc2cc1NC(=O)c1csc2cnc(NC3CC3)nc12 CHEMBL3903936 IC50 575.0 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 Kd 600.0 nM
O=C(Nc1cc(Cl)ccc1O[C@H]1CC[C@H](O)CC1)c1csc2cncnc12 CHEMBL3900127 IC50 600.0 nM
O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1-c1ccccc1)c1cccc(C(F)(F)F)c1 CHEMBL3736278 Ki 608.0 nM
COc1cc2ncccc2cc1NC(=O)c1csc2cnc(NCC(O)CO)nc12 CHEMBL3899862 IC50 608.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 609.0 nM
Cc1cc(C)cc(NC(=O)Nc2ccc3c(c2)CCc2sc4ncnc(N)c4c2-3)c1 CHEMBL1964687 pKi 630.96 nM
COc1cc(C)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL1975233 pKi 630.96 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL1967531 pKi 630.96 nM
NC(=O)c1ccc(-c2c[nH]c3nccc(Cl)c23)cc1 CHEMBL1982711 pKi 630.96 nM
COc1cccc(C(C)NC(=O)c2ccc(-c3ccncc3C)cc2)c1 CHEMBL1970217 pKi 630.96 nM
OCCC(Nc1nc2ccc(-c3ccncc3)cc2s1)c1ccccc1 CHEMBL1982122 pKi 630.96 nM
COc1cc2c(cc1F)C(c1ccccc1Cl)=Nc1c(n[nH]c1C)N2 CHEMBL1980391 pKi 630.96 nM
O=C(Nc1cc(Cl)ccc1N1CCCCC1)c1cnn2nc(O)cnc12 CHEMBL3930442 IC50 644.0 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1171837 Kd apparent 691.0 nM
O=C(Nc1cc(Cl)ccc1N1CCC(CO)CC1)c1csc2cncnc12 CHEMBL3898083 IC50 700.0 nM
COc1cc2ncccc2cc1NC(=O)c1csc2cnc(NCCN)nc12 CHEMBL3943097 IC50 712.0 nM
CCOC(=O)Cn1c(NC(=O)c2cccc([N+](=O)[O-])c2)nc2ccccc21 CHEMBL210194 IC50 750.0 nM
CC(O)CC(C)Oc1cc2ncccc2cc1NC(=O)c1csc2cncnc12 CHEMBL3893473 IC50 760.0 nM
CN(C)c1ccc(CNC(=O)c2cc3c(-c4ccccc4)n[nH]c3s2)cc1 CHEMBL1984367 pKi 794.33 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL1972158 pKi 794.33 nM
O=C(Nc1cccc(Cl)c1)Nc1ncc(CCNc2ncnc3ccsc23)s1 CHEMBL482767 pKi 794.33 nM
Nc1ncnc2sc(Br)c(-c3ccc(NC(=O)Cc4cccc(Cl)c4)cc3)c12 CHEMBL1980896 pKi 794.33 nM
NC(=O)c1cc2c(-c3ccc(F)cc3)cncc2s1 CHEMBL1974310 pKi 794.33 nM
COc1ccc(C=C2SC(=Nc3ccccc3)NC2=O)cc1O CHEMBL2000354 pKi 794.33 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(-c3c(C)sc4ncnc(N)c34)cc2)c1 CHEMBL371206 pKi 794.33 nM
O=c1nc(-c2cc3c(Oc4ccc(I)cc4)cncc3s2)[nH]o1 CHEMBL497151 pKi 794.33 nM
NCC1CCC(CNc2nc(NCc3ccccc3Cl)ncc2[N+](=O)[O-])CC1 CHEMBL246970 pKi 794.33 nM
O=C1Cc2c([nH]c3ccc([N+](=O)[O-])cc23)-c2ccccc2N1 CHEMBL50894 pKi 794.33 nM
COc1cccc(C(C)NC(=O)N2CC=C(c3c[nH]c4ncccc34)CC2)c1 CHEMBL1965845 pKi 794.33 nM
NCC1CCN(c2ccc(Cl)cc2NC(=O)c2csc3cncnc23)CC1 CHEMBL3944795 IC50 800.0 nM
Cc1cc(-c2nc(C(=O)Nc3cn(C4CCOCC4)nc3C(N)=O)co2)ccn1 CHEMBL3353187 IC50 800.0 nM
COc1ccc(Cl)cc1NC(=O)c1csc2cnc(NCCN)nc12 CHEMBL3942983 IC50 813.0 nM
O=C(Nc1cc2ccccc2cc1OC1CCC(O)CC1)c1cnn2cccnc12 CHEMBL3937613 IC50 817.0 nM
O=C(Nc1cc(Cl)ccc1N1CCC(CO)CC1)c1cnn2cc(O)cnc12 CHEMBL3944798 IC50 836.0 nM
NCC1CCN(c2cc3ncccc3cc2NC(=O)c2csc3cncnc23)CC1 CHEMBL3953525 IC50 850.0 nM
CC(O)C1CCN(c2ccc(Cl)cc2NC(=O)c2cnn3cccnc23)C1 CHEMBL3889839 IC50 897.0 nM
CC(C)(C)C(=O)Oc1ccc2c(c1)nc(NC(=O)c1cccc([N+](=O)[O-])c1)n2-c1ccc(CCCO)cc1 CHEMBL3735448 IC50 900.0 nM
c1nc(N[C@H]2CC[C@@H](N3CCOCC3)CC2)c2c(C3CCOCC3)c[nH]c2n1 CHEMBL4094760 IC50 910.0 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL1802358 Kd 930.0 nM
O=C(Nc1cc(Cl)ccc1OC1CCNCC1)c1csc2cccnc12 CHEMBL3902407 IC50 930.0 nM
CC(O)C1CCN(c2ccc(Cl)cc2NC(=O)c2cnn3cccnc23)CC1 CHEMBL3890299 IC50 970.0 nM
COc1cc2ncccc2cc1NC(=O)c1csc2cnc(N(C)CCN)nc12 CHEMBL3353220 IC50 982.5 nM
COc1ccc(CNc2c(Nc3ccncc3)c(=O)c2=O)c(OC)c1 CHEMBL2003768 pKi 1000.0 nM
O=C1CCCN1Cc1ccc2c(c1)[nH]c(=O)c1cccn12 CHEMBL539474 pKi 1000.0 nM
COc1cccc(C(C)NC(=O)c2ccc(-c3ccncc3)cc2)c1 CHEMBL1975121 pKi 1000.0 nM
Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)cncc21 CHEMBL1964692 pKi 1000.0 nM
O=C1NN=Cc2c[nH]c3cc(NC(=O)C4CC4c4ccccc4)cc1c23 CHEMBL1969502 pKi 1000.0 nM
Cc1ccc(-c2ccc(NC(=O)Nc3cccc(Br)c3)cc2)c2c(N)n[nH]c12 CHEMBL1973937 pKi 1000.0 nM
Cc1cccc(Nc2nccc(Nc3c(NC(C)C(C)(C)C)c(=O)c3=O)n2)c1 CHEMBL1969523 pKi 1000.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccccc4)c3)cc12 CHEMBL2002726 pKi 1000.0 nM
c1ccc(CNc2nc3ccc(-c4ccncc4)cc3s2)cc1 CHEMBL1983534 pKi 1000.0 nM
CSc1ccccc1CNc1ncc([N+](=O)[O-])c(NCC2CCC(CN)CC2)n1 CHEMBL392642 pKi 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM