Cc1cc(-c2nc(C(=O)Nc3cn(C4CCS(=O)(=O)CC4)nc3C(N)=O)co2)ccn1 CHEMBL5266792 IC50 -9.5 nM
CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)CCOCCOCCOCC#Cc2cnc(OC[C@@H]3CCC(=O)N3)c3cc(OC)c(C(N)=O)cc23)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1 CHEMBL4443947 IC50 0.022 nM
CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCC(N4CCC4)CC3)cc2C1=O CHEMBL4556091 IC50 0.026 nM
CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCN(C4COC4)CC3)cc2C1=O CHEMBL4566431 IC50 0.078 nM
CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCN(CC(F)F)CC3)cc2C1=O CHEMBL4545898 IC50 0.081 nM
COc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(C#CCCCCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)c2cc1C(N)=O CHEMBL4448950 IC50 0.099 nM
CC[C@H]1[C@@H](COc2nccc3cc(C(N)=O)c(OC)cc23)NC(=O)[C@@H]1F CHEMBL4066705 IC50 0.1 nM
CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCN(C4CC(F)(F)C4)CC3)cc2C1=O CHEMBL4445098 IC50 0.1 nM
COc1cc2nn([C@H]3CC[C@@]4(CCC(=O)N4C)CC3)cc2cc1C(=O)Nc1cnc2cccnn12 CHEMBL5190644 IC50 0.1 nM
CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCC(N4CC(F)(F)C4)CC3)cc2C1=O CHEMBL4568894 IC50 0.11 nM
CC(C)(O)CCN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2C1=O CHEMBL4472406 IC50 0.16 nM
CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2C1=O CHEMBL4475494 IC50 0.19 nM
Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCC[C@@H]4N)nc23)c(C(F)F)n1 CHEMBL3590479 IC50 0.2 nM
Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCC[C@@H]4N)nc23)c(C(F)F)n1 CHEMBL3634383 IC50 0.2 nM
Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCCNC4)nc23)c(C(F)F)n1 CHEMBL3634510 IC50 0.2 nM
CC[C@@H]1[C@H](F)C(=O)N[C@@H]1COc1nccc2cc(C(N)=O)c(OC)cc12 CHEMBL4081711 IC50 0.2 nM
CC[C@@H]1[C@H](F)C(=O)N[C@@H]1COc1cccc2cc(C(N)=O)c(OC)cc12 CHEMBL4520946 IC50 0.2 nM
COc1cc2nn([C@H]3CC[C@H](N(C)C(C)=O)CC3)cc2cc1C(=O)Nc1cnc2cccnn12 CHEMBL5202941 IC50 0.2 nM
COc1cc2nn([C@H]3CC[C@@]4(CC3)CC(=O)N(C)C4)cc2cc1C(=O)Nc1cnc2cccnn12 CHEMBL5176061 IC50 0.2 nM
COc1cc2nn([C@H]3CC[C@H](N(C)C(=O)[C@@H](C)O)CC3)cc2cc1C(=O)Nc1cnc2cccnn12 CHEMBL5196239 IC50 0.2 nM
Cn1cc(NC(=O)c2coc(-c3ccnc(NCC(F)(F)F)c3)n2)c(C(N)=O)n1 CHEMBL3353189 IC50 0.24 nM
COc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(C#CCOCCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)c2cc1C(N)=O CHEMBL4524299 IC50 0.29 nM
Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCC[C@@H]4N)nc23)c(C(N)=O)n1 CHEMBL3590474 IC50 0.3 nM
Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCC[C@@H]4N)nc23)c(C(F)(F)F)n1 CHEMBL3590478 IC50 0.3 nM
Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCC[C@@H]4N)nc23)c(Cl)n1 CHEMBL3634613 IC50 0.3 nM
COc1cc2c(OC[C@H]3NC(=O)[C@@H](F)[C@H]3C)nccc2cc1C(N)=O CHEMBL4093120 IC50 0.3 nM
COc1cc2nn([C@H]3CC[C@H](N(C)C(=O)N4CC[C@@H](O)C4)CC3)cc2cc1C(=O)Nc1cnc2cccnn12 CHEMBL5204583 IC50 0.3 nM
COc1cc2nn([C@H]3CC[C@H](N(C)C(=O)[C@@H](C)O)CC3)cc2cc1C(=O)Nc1cccn(-c2cn[nH]c2)c1=O CHEMBL5410702 IC50 0.3 nM
Cc1cc(Nc2ncc(-c3nc4ccccc4s3)c(NC3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc(C)n1 CHEMBL3353199 IC50 0.32 nM
COC(C)(C)CCN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2C1=O CHEMBL4466981 IC50 0.32 nM
CC(C)(C)C(=O)Nc1ccc2c(c1)nc(NC(=O)c1cccc(C(F)(F)F)c1)n2[C@H]1CC[C@@H](CO)CC1 CHEMBL3735504 Ki 0.34 nM
NC(=O)c1nn(-c2cccnc2)cc1NC(=O)c1coc(-c2ccnc(NCC(F)(F)F)c2)n1 CHEMBL3353188 IC50 0.36 nM
CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2C1=O CHEMBL4468790 IC50 0.38 nM
Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCNC4)nc23)c(C(F)F)n1 CHEMBL3634509 IC50 0.4 nM
Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCC[C@@H]4N)nc23)c(C#N)n1 CHEMBL3634616 IC50 0.4 nM
COc1cc2nn([C@H]3CC[C@H](N(C)C(=O)[C@@H](C)O)CC3)cc2cc1C(=O)Nc1cccn(CF)c1=O CHEMBL5428211 IC50 0.4 nM
COc1cc2nn([C@H]3CC[C@]4(CC3)COC(=O)N4C)cc2cc1C(=O)Nc1cccn(C)c1=O CHEMBL5421046 IC50 0.4 nM
O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1[C@H]1CC[C@@H](CO)CC1)c1cccc(C(F)(F)F)c1 CHEMBL3736036 Ki 0.42 nM
O=C(Nc1cc2c(cc1N1CCOCC1)C(=O)N(CC1CCOCC1)C2)c1cnn2cccnc12 CHEMBL4452765 IC50 0.47 nM
O=C(Nc1nc2ccc(CO)cc2n1[C@H]1CC[C@@H](CO)CC1)c1cccc(C(F)(F)F)c1 CHEMBL3734814 Ki 0.48 nM
Cn1cc(NC(=O)c2cnn3ccc(N4C[C@H](N)CC(F)(F)C4)nc23)c(C(F)F)n1 CHEMBL3590515 IC50 0.5 nM
Cn1cc(NC(=O)c2cnn3ccc(N4C[C@H](N)C[C@@H](F)C4)nc23)c(C(F)(F)F)n1 CHEMBL3590516 IC50 0.5 nM
Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC[C@@H]4N)nn23)c(C(F)F)n1 CHEMBL3634381 IC50 0.5 nM
O=C(Nc1nc2cc(CN3CCCC3=O)ccc2n1[C@H]1CC[C@H](O)CC1)c1cccc([N+](=O)[O-])c1 CHEMBL3734872 Ki 0.5 nM
CC[C@@H]1CC(=O)N[C@@H]1COc1nccc2cc(C(N)=O)c(OC)cc12 CHEMBL4091434 IC50 0.5 nM
O=C(Nc1cc2sc(N3CCOCC3)nc2cc1N1CCC(CO)CC1)c1cnn2cccnc12 CHEMBL4474636 Ki 0.5 nM
CN(C)c1nc2cc(N3CCC(CO)CC3)c(NC(=O)c3cnn4cccnc34)cc2s1 CHEMBL4464832 Ki 0.5 nM
COc1cc2nn([C@H]3CC[C@H](n4ccccc4=O)CC3)cc2cc1C(=O)Nc1cccn(C)c1=O CHEMBL5408807 IC50 0.5 nM
COc1cc2nn([C@H]3CC[C@H](n4ccnc4C(C)O)CC3)cc2cc1C(=O)Nc1cccn(C)c1=O CHEMBL5412221 IC50 0.5 nM
CN(C)CCn1cc2cc(NC(=O)c3cccc(C(F)(F)F)n3)c(C(C)(C)O)cc2n1 CHEMBL4791626 IC50 0.55 nM
COc1cc2c(OC[C@H]3NC(=O)[C@@]4(F)[C@@H]3[C@@H]4C)nccc2cc1C(N)=O CHEMBL4085199 IC50 0.6 nM
CN1CC[C@H](n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(C)ccc4n3)cn2)[C@H](F)C1 CHEMBL5193253 IC50 0.6 nM
C[C@H]1C[C@@H](n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(C)ccc4n3)cn2)CCN1C CHEMBL5200601 IC50 0.6 nM
CN1CCC(n2cc(Nc3nc(OC4(C)CC4)c4nc(-c5cncnc5)ccc4n3)cn2)CC1 CHEMBL5283628 IC50 0.6 nM
Cc1ncc(-c2nc3c(NC4(C)CC4)nc(Nc4cnn(C5CC6(C5)CN(C)C6)c4)nc3cc2F)cn1 CHEMBL5270030 IC50 0.6 nM
COc1cc2nn([C@H]3CC[C@H](N(C)C(=O)[C@@H](C)O)CC3)cc2cc1C(=O)Nc1cccn(C2CC2)c1=O CHEMBL5397509 IC50 0.6 nM
Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCCNC4)nn23)c(C(F)F)n1 CHEMBL3634511 IC50 0.7 nM
Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC[C@@H]4N)nn23)c(C#N)n1 CHEMBL3634615 IC50 0.7 nM
O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1[C@H]1CC[C@@H](CO)CC1)c1cccc([N+](=O)[O-])c1 CHEMBL3734854 Ki 0.7 nM
c1nc(N[C@H]2CC[C@H](N3CCOCC3)CC2)c2c(C3CCOCC3)c[nH]c2n1 CHEMBL4064608 Kd 0.7 nM
Cn1cc(NC(=O)c2ccc3cnc(NC4CCCCC4N)nn23)c(C(N)=O)n1 CHEMBL5282803 IC50 0.7 nM
Cc1cc(Nc2ncc(-c3ccc4ccccc4n3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc(C)n1 CHEMBL3601192 IC50 0.74 nM
Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCC[C@@H]4N)nc23)c(C#N)n1 CHEMBL3590477 IC50 0.8 nM
Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCNC4)nc23)c(C(F)(F)F)n1 CHEMBL3634505 IC50 0.8 nM
O=C(Nc1cc2sc(N3CCOCC3)nc2cc1N1CCOCC1)c1cnn2cccnc12 CHEMBL4568867 Ki 0.8 nM
CN(C)C(=O)CN1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(C)ccc4n3)cn2)CC1 CHEMBL5201376 IC50 0.8 nM
COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cnn(C)c1 CHEMBL5176837 IC50 0.8 nM
Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCNC4)nn23)c(C(F)F)n1 CHEMBL3634508 IC50 0.9 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(S(C)(=O)=O)c1 CHEMBL4113747 IC50 0.9 nM
Clc1ccc2ncc(-c3cccc(NC4CCNC4)n3)n2c1 CHEMBL401633 IC50 1.0 nM
Clc1ccc2ncc(-c3cccc(NC4CCNCC4)n3)n2c1 CHEMBL256570 IC50 1.0 nM
NC(=O)[C@@H](O)C[C@H]1CCc2sc3ncnc(O[C@H]4CC[C@H](N5CCOCC5)CC4)c3c21 CHEMBL3361255 Ki 1.0 nM
NCC1CCN(c2ccc(Cl)cc2NC(=O)c2cnn3cc(O)cnc23)CC1 CHEMBL3353219 IC50 1.0 nM
Cn1cc(NC(=O)c2cnn3ccc(N4CCNCC4)nc23)c(C(F)F)n1 CHEMBL3590488 IC50 1.0 nM
Cn1cc(NC(=O)c2cnn3ccc(N4C[C@H](N)CC(F)(F)C4)nc23)c(C(F)(F)F)n1 CHEMBL3590493 IC50 1.0 nM
Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCC[C@@H]4N)nc23)c(C(F)(F)F)n1 CHEMBL3634380 IC50 1.0 nM
Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC[C@@H]4N)nn23)c(C(F)F)n1 CHEMBL3634382 IC50 1.0 nM
Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCNC4)nn23)c(C(F)(F)F)n1 CHEMBL3634504 IC50 1.0 nM
Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCNC4)nn23)c(C(F)F)n1 CHEMBL3634507 IC50 1.0 nM
Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC[C@@H]4N)nn23)c(Cl)n1 CHEMBL3634513 IC50 1.0 nM
Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC[C@@H]4N)nn23)c(Cl)n1 CHEMBL3634514 IC50 1.0 nM
Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC[C@@H]4N)nn23)c(C#N)n1 CHEMBL3634614 IC50 1.0 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCOCC1 CHEMBL4106870 IC50 1.0 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCC1 CHEMBL4108575 IC50 1.0 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCC(F)C1 CHEMBL4112434 IC50 1.0 nM
CC(C)(C)Nc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4106804 IC50 1.0 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1COC1 CHEMBL4106613 IC50 1.0 nM
COC(=O)N1CCN([C@H]2CC[C@H](Nc3nc(Nc4cnn(C)c4)nc4ccc(C#N)cc34)CC2)CC1 CHEMBL4439748 IC50 1.0 nM
CC(=O)N1CCN([C@H]2CC[C@H](Nc3nc(Nc4cnn(C)c4)nc4ccc(C#N)cc34)CC2)CC1 CHEMBL4539647 IC50 1.0 nM
CN1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(C)ccc4n3)cn2)CC1 CHEMBL5174529 IC50 1.0 nM
CN(C)CC(=O)N1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(C)ccc4n3)cn2)CC1 CHEMBL5200432 IC50 1.0 nM
CN1CC[C@H](n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(C)ccc4n3)cn2)[C@@H](F)C1 CHEMBL5209502 IC50 1.0 nM
CN1CC2(CC(n3cc(Nc4nc(NC5(C)CC5)c5c(=O)n(C)ccc5n4)cn3)C2)C1 CHEMBL5193024 IC50 1.0 nM
CN1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(-c5cnn[nH]5)ccc4n3)cn2)CC1 CHEMBL5193053 IC50 1.0 nM
CN1CCC(n2cc(Nc3nc(OC4(C)CC4)c4nc(-c5cccnc5)ccc4n3)cn2)CC1 CHEMBL5288696 IC50 1.0 nM
CN1CCC(n2cc(Nc3nc(OC4(C)CC4)c4nc(-c5ccnnc5)ccc4n3)cn2)CC1 CHEMBL5281595 IC50 1.0 nM
CN1CCC(n2cc(Nc3nc(OC4(C)CC4)c4nc(-c5cncnc5)c(F)cc4n3)cn2)CC1 CHEMBL5290090 IC50 1.0 nM
CCn1cc(NC(=O)c2ccc3cnc(NC4CCCCC4N)nn23)c(C(N)=O)n1 CHEMBL5266861 IC50 1.0 nM
CC(C)Nc1cc(-n2ccc3cncnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4110834 IC50 1.1 nM
CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2NC(C)C)CC1 CHEMBL3902828 IC50 1.1 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cc(C2CC2)n[nH]1 CHEMBL4112384 IC50 1.1 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CCC(F)C1 CHEMBL4110840 IC50 1.1 nM
CC1(C)Cc2cc(NC(=O)c3cnn4cc(C(N)=O)cnc34)c(N3CCOCC3)cc2O1 CHEMBL4520118 Ki 1.1 nM
CC(C)(C)C(=O)Oc1ccc2c(c1)nc(NC(=O)c1cccc([N+](=O)[O-])c1)n2CCCO CHEMBL1236126 Ki 1.2 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC12CCC(O)(CC1)C2 CHEMBL4107911 IC50 1.2 nM
CC1(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)CC1 CHEMBL4114460 IC50 1.2 nM
CCn1cc(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1 CHEMBL4106801 IC50 1.2 nM
COC(=O)N1CC[C@@H](Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)C1 CHEMBL4110862 IC50 1.2 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@H]1CC[C@H](C(N)=O)CC1 CHEMBL4106665 IC50 1.2 nM
CC(C)(F)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1cccc(O)c1 CHEMBL4109209 IC50 1.2 nM
CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2S1(=O)=O CHEMBL4536154 IC50 1.2 nM
O=C(Nc1cc2oc(N3CCOCC3)nc2cc1N1CCC(CO)CC1)c1cnn2cccnc12 CHEMBL4515682 Ki 1.2 nM
O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1-c1ccc(CCO)cc1)c1cccc(C(F)(F)F)c1 CHEMBL3736465 Ki 1.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@H]1CC[C@@](C)(O)CC1 CHEMBL4114114 IC50 1.3 nM
Cn1nnnc1-c1ccc(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cc1 CHEMBL4110352 IC50 1.3 nM
CC(C)Nc1cc(-n2ccc3cnc(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4111162 IC50 1.3 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4109233 IC50 1.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)F)c1 CHEMBL4111280 IC50 1.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(Cl)cnc32)cc1Nc1cnn(CC(F)F)c1 CHEMBL4110464 IC50 1.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(Cl)cnc32)cc1Nc1cnn(CCCF)c1 CHEMBL4111498 IC50 1.3 nM
Cn1cc(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1 CHEMBL4108510 IC50 1.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@@H]1CCN(S(C)(=O)=O)C1 CHEMBL4111288 IC50 1.3 nM
COc1cc2c(OC[C@@H]3CCC(=O)N3)cccc2cc1C(N)=O CHEMBL4083655 IC50 1.3 nM
CCC[C@@H]1CC(=O)N[C@@H]1COc1nccc2cc(C(N)=O)c(OC)cc12 CHEMBL4103497 IC50 1.3 nM
Cn1cc(NC(=O)c2cnc3ccc(N[C@@H]4CCCNC4)nn23)c(C(F)F)n1 CHEMBL4791581 IC50 1.3 nM
CCNc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4115161 IC50 1.4 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCC(O)C1 CHEMBL4107813 IC50 1.4 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)O CHEMBL4109646 IC50 1.4 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](C(C)(C)O)CC1 CHEMBL3904136 IC50 1.4 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](C(C)(C)O)CC1 CHEMBL3985561 IC50 1.4 nM
CCCn1cc(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1 CHEMBL4111230 IC50 1.4 nM
C[C@H](F)CNc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL3921810 IC50 1.4 nM
CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(Nc3ccc4ncsc4n3)cc2NC2CCOCC2)CC1 CHEMBL3353195 IC50 1.5 nM
COC(C)(C)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC(C)C CHEMBL4108325 IC50 1.5 nM
C[C@@H](CO)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL3984144 IC50 1.5 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1cccc(NS(C)(=O)=O)c1 CHEMBL4109266 IC50 1.5 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NCC1(F)CCC1 CHEMBL4106742 IC50 1.5 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1cccc(CO)c1 CHEMBL4110216 IC50 1.5 nM
CC(C)Nc1cc(-n2ccc3cc(Cl)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4115627 IC50 1.5 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(Cl)cnc32)cc1Nc1cnn(CC(F)(F)F)c1 CHEMBL4107445 IC50 1.5 nM
CCNC(=O)n1cc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1 CHEMBL4114115 IC50 1.5 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(-c2ncccn2)c1 CHEMBL4107792 IC50 1.5 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2NC2CC2)CC1 CHEMBL3908153 IC50 1.5 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@@H]1CCN(c2ncc(F)cn2)C1 CHEMBL4110783 IC50 1.5 nM
C[C@@H](F)CNc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4112802 IC50 1.5 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@@H]1CCN(c2ncc(F)cn2)C1 CHEMBL4108248 IC50 1.5 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)c(N)nc32)cc1NC12CC(C1)C2 CHEMBL4108474 IC50 1.5 nM
CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCC(CO)CC3)cc2O1 CHEMBL4467170 Ki 1.5 nM
CC(C)CCn1cc(-c2cnc3c([nH]c4cc(C#N)ccc43)c2NC(C)C)nn1 CHEMBL5083433 IC50 1.5 nM
CC(C)Nc1c(-c2cn(C3CCNCC3)nn2)cnc2c1[nH]c1cc(C#N)ccc12 CHEMBL5088802 IC50 1.5 nM
O=C(Nc1nc2cc(F)ccc2n1[C@H]1CC[C@@H](CO)CC1)c1cccc([N+](=O)[O-])c1 CHEMBL3735949 Ki 1.6 nM
COC(C)(C)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCCC(CO)C1 CHEMBL4109207 IC50 1.6 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CC1 CHEMBL4111587 IC50 1.6 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCCOC1 CHEMBL4109973 IC50 1.6 nM
CC(C)Nc1cc(-n2ccc3cc(F)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4115151 IC50 1.6 nM
CC(C)(O)c1cccc(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)c1 CHEMBL4110722 IC50 1.6 nM
CC(=O)Nc1ccc(CCNC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC(C)C)cc1 CHEMBL3963886 IC50 1.6 nM
CC[C@@H](C)Nc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4112913 IC50 1.6 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(-c2ncc(F)cn2)c1 CHEMBL4109069 IC50 1.6 nM
CC(CCF)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4107752 IC50 1.6 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@H]1C[C@H](C(C)(C)O)C1 CHEMBL4114306 IC50 1.6 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C(N)=O)cnc32)cc1Nc1ccc2ncoc2c1 CHEMBL4110605 IC50 1.6 nM
CCNc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2c1[nH]c1cc(C#N)ccc12 CHEMBL5087642 IC50 1.6 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 1.7 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 Kd 1.7 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCCC(C)(C)O CHEMBL3965584 IC50 1.7 nM
CC(C)(O)CCNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCOCC1 CHEMBL3925564 IC50 1.7 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1ccc2ncsc2c1 CHEMBL4109550 IC50 1.7 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1cccc(C#N)c1 CHEMBL4107134 IC50 1.7 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1ccc(-n2cccn2)cc1 CHEMBL4106842 IC50 1.7 nM
CCNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2NC(C)C)CC1 CHEMBL3889742 IC50 1.7 nM
CS(=O)(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2NC2CC2)CC1 CHEMBL3956425 IC50 1.7 nM
CC(C)Nc1cc(-n2ccc3cnc(NCCO)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4106756 IC50 1.7 nM
CC(C)(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4107447 IC50 1.7 nM
CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC(C)C)CC1 CHEMBL3900682 IC50 1.7 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)(F)F)c1 CHEMBL4109434 IC50 1.7 nM
CCn1cc(Nc2cc(-n3ncc4cc(Cl)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1 CHEMBL4110545 IC50 1.7 nM
CC(F)(F)Cn1cc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1 CHEMBL4113628 IC50 1.7 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCN(S(C)(=O)=O)CC1 CHEMBL4108543 IC50 1.7 nM
O=C(Nc1cc2cccnc2cc1N1CCC(CO)CC1)c1cnn2cccnc12 CHEMBL4453861 Ki 1.7 nM
O=C(Nc1cc2[nH]c(N3CCOCC3)nc2cc1N1CCC(CO)CC1)c1cnn2cccnc12 CHEMBL4460055 Ki 1.7 nM
CNC(=O)c1nc(-c2cnc(Nc3ccc4ncsc4c3)cc2NC(C)C)sc1C CHEMBL3353197 IC50 1.8 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(Nc2ncc(C#N)cc2Cl)cc1NC1CC1 CHEMBL3353191 IC50 1.8 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCCC1 CHEMBL4114980 IC50 1.8 nM
CC(CCO)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4110098 IC50 1.8 nM
CC(=O)Nc1cccc(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)c1 CHEMBL4111696 IC50 1.8 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1ccc(C(N)=O)cc1 CHEMBL4109312 IC50 1.8 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCOCC1F CHEMBL4107284 IC50 1.8 nM
C[C@H](CF)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4106949 IC50 1.8 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@@](F)(c2nccn2C)CC1 CHEMBL3945800 IC50 1.8 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(C2COC2)c1 CHEMBL4107087 IC50 1.8 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)F)c1 CHEMBL4109866 IC50 1.8 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1ccn(CC(F)(F)F)n1 CHEMBL4107994 IC50 1.8 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NCCC(F)(F)F CHEMBL4115121 IC50 1.8 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1ccc2nn[nH]c2c1 CHEMBL4110300 IC50 1.8 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCC(F)C1(O)COC1 CHEMBL3975254 IC50 1.8 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC12CC(C1)C2 CHEMBL4111872 IC50 1.8 nM
Cn1c(N2CCOCC2)nc2cc(N3CCC(CO)CC3)c(NC(=O)c3cnn4cccnc34)cc21 CHEMBL4483477 Ki 1.8 nM
Cc1ncc(-c2ccc3nc(Nc4cnn(C5CCN(C)CC5)c4)nc(OC4(C)CC4)c3n2)cn1 CHEMBL5273100 IC50 1.8 nM
CC(C)Nc1cc(Nc2ncc(C#N)cc2Cl)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL3353190 IC50 1.9 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(Cl)cnc32)cc1NC1CCOCC1 CHEMBL4113144 IC50 1.9 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cncnc32)cc1NC1CC1 CHEMBL4114107 IC50 1.9 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1cccc(S(N)(=O)=O)c1 CHEMBL4107511 IC50 1.9 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CC(F)(F)C1 CHEMBL4115586 IC50 1.9 nM
CC(=O)N[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2NC2CC2)CC1 CHEMBL3929809 IC50 1.9 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](C(=O)NC(C)C)CC1 CHEMBL3895223 IC50 1.9 nM
CC(CF)Nc1cc(-n2ccc3cncnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4109783 IC50 1.9 nM
CC(C)Nc1cc(-n2ccc3cnc(NCC(C)(C)O)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4106447 IC50 1.9 nM
CC[C@H](C)Nc1cc(-n2ncc3cc(Cl)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL3895603 IC50 1.9 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)F CHEMBL4109739 IC50 1.9 nM
CC(C)Nc1cc(-n2cnc3cc(C#N)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4109597 IC50 1.9 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(Cl)cnc32)cc1Nc1cnn(CC(F)(F)F)c1 CHEMBL4115019 IC50 1.9 nM
CC(F)(F)Cn1cc(Nc2cc(-n3ncc4cc(Cl)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1 CHEMBL4114244 IC50 1.9 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1ccc2ncoc2c1 CHEMBL4110814 IC50 1.9 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@@H]1CCOC1 CHEMBL4111861 IC50 1.9 nM
COC(=O)N1CC(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)C1 CHEMBL4114846 IC50 1.9 nM
C[C@H](F)CNc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL3924209 IC50 1.9 nM
COc1cc2c(OC[C@H]3NC(=O)[C@H](F)[C@H]3C)nccc2cc1C(N)=O CHEMBL4071526 IC50 1.9 nM
CC(C)Nc1c(C(=O)NCCC2CCNC2)cnc2c1[nH]c1cc(C#N)ccc12 CHEMBL5074470 IC50 1.9 nM
c1cc(NC2CCNCC2)nc(-c2cnc3ccc(-c4cc[nH]n4)cn23)c1 CHEMBL255867 IC50 2.0 nM
N[C@H]1CCCC[C@H]1Nc1cccc2nc(-c3c(N[C@@H]4CCCNC4)nc(N4CCOCC4)[nH]c3=O)sc12 CHEMBL3353205 IC50 2.0 nM
Cc1ccc(-n2nc(N3CCN(S(C)(=O)=O)CC3)cc2NC(=O)c2cnn3cccnc23)nc1 CHEMBL3586511 IC50 2.0 nM
Cn1cc(NC(=O)c2cnn3ccc(NCCN)nc23)c(C(N)=O)n1 CHEMBL3590438 IC50 2.0 nM
Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCC[C@@H]4N)nc23)c(C(F)(F)C(F)(F)F)n1 CHEMBL3590480 IC50 2.0 nM
COc1cc(Nc2ncc(-c3nc4ccncc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)ccn1 CHEMBL3601079 IC50 2.0 nM
Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC[C@@H]4N)nn23)c(C(F)(F)F)n1 CHEMBL3634378 IC50 2.0 nM
Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCNC4)nn23)c(C(F)(F)F)n1 CHEMBL3634503 IC50 2.0 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cncnc32)cc1NC1CCOCC1 CHEMBL4112273 IC50 2.0 nM
CC(F)[C@H](C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL3946796 IC50 2.0 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](C(=O)NC2CC2)CC1 CHEMBL3926706 IC50 2.0 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NCCC(C)(C)F CHEMBL3976685 IC50 2.0 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CN(c2ncc(F)cn2)C1 CHEMBL4111218 IC50 2.0 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCCC1(O)CCCC1 CHEMBL3977494 IC50 2.0 nM
O=c1[nH]c(N2CCOCC2)nc(NCCN2CCCCC2)c1-c1nc2ccccc2s1 CHEMBL3945726 IC50 2.0 nM
N[C@H]1CCCC[C@H]1Nc1cccc2sc(-c3c(N[C@@H]4CCCNC4)nc(N4CCOCC4)[nH]c3=O)nc12 CHEMBL4113995 IC50 2.0 nM
NCC1CCN(c2cc3ncccc3cc2NC(=O)c2cnn3cccnc23)CC1 CHEMBL3950656 IC50 2.0 nM
CN1C(=O)C[C@@H]2CN([C@H]3CC[C@H](Nc4ncnc5[nH]cc(C6CCOCC6)c45)CC3)CC[C@@H]21 CHEMBL4078222 IC50 2.0 nM
CN1C(=O)C[C@H]2CN([C@H]3CC[C@H](Nc4ncnc5[nH]cc(C6CCOCC6)c45)CC3)CC[C@H]21 CHEMBL4102501 IC50 2.0 nM
CC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnc4[nH]cc(C5CCOCC5)c34)CC2)CC1 CHEMBL4080574 IC50 2.0 nM
Cn1cc(Nc2nc(N[C@H]3CC[C@H](N4CCOCC4)CC3)c3cc(C#N)ccc3n2)cn1 CHEMBL4452521 IC50 2.0 nM
Cc1cc(-c2nc(C(=O)Nc3cc4oc(N5CCOCC5)nc4nc3N3CCCC(F)C3)co2)ccn1 CHEMBL4789918 IC50 2.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2ccoc2)[C@H]2C=C[C@@H]1C2 CHEMBL5075301 IC50 2.0 nM
CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2c1[nH]c1cc(C#N)ccc12 CHEMBL5082351 IC50 2.0 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc2c([nH]c3cc(C#N)ccc32)c1NC1CCC1 CHEMBL5094956 IC50 2.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cc(F)cc(C(=O)N4CCCC4)c3)nc3ccsc23)[C@H]2C=C[C@@H]1C2 CHEMBL5169945 IC50 2.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc3ccn(C(F)F)c23)[C@H]2C=C[C@@H]1C2 CHEMBL5187995 IC50 2.0 nM
Cn1cc(Nc2nc(NC3(C)CC3)c3nc(CC#N)ccc3n2)cn1 CHEMBL5179237 IC50 2.0 nM
CN1CC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(C)ccc4n3)cn2)CCC1=O CHEMBL5178970 IC50 2.0 nM
CC(=O)N1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(C)ccc4n3)cn2)CC1 CHEMBL5207332 IC50 2.0 nM
CN1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(CC(F)F)ccc4n3)cn2)CC1 CHEMBL5186874 IC50 2.0 nM
C[C@H](F)Cn1ccc2nc(Nc3cnn(C4CCN(C)CC4)c3)nc(NC3(C)CC3)c2c1=O CHEMBL5190750 IC50 2.0 nM
C[C@H](F)Cn1ccc2nc(Nc3cnn(C4CC5(C4)CN(C)C5)c3)nc(NC3(C)CC3)c2c1=O CHEMBL5207654 IC50 2.0 nM
CN1CCC(n2cc(Nc3nc(OC4(C)CC4)c4nc(C5CC5)ccc4n3)cn2)CC1 CHEMBL5281524 IC50 2.0 nM
Cc1ncc(-c2nc3c(NC(C)C)nc(Nc4cnn(C5CC6(C5)CN(C)C6)c4)nc3cc2F)cn1 CHEMBL5274954 IC50 2.0 nM
NCCNc1ncc2ccc(C(=O)Nc3cn(CCO)nc3C(N)=O)n2n1 CHEMBL5277765 IC50 2.0 nM
CCCNc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4108677 IC50 2.1 nM
CC(C)(O)CNc1cc(-n2ccc3cc(Cl)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4107696 IC50 2.1 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1ccc(-n2cncn2)cc1 CHEMBL4113542 IC50 2.1 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)(F)F)c1 CHEMBL4115559 IC50 2.1 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(CCC#N)c1 CHEMBL4111974 IC50 2.1 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1cccc(C#N)c1F CHEMBL4108627 IC50 2.1 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1cccc(-c2ncc[nH]2)c1 CHEMBL4113582 IC50 2.1 nM
C[C@@H](CO)Nc1cc(-n2ccc3cc(F)cnc32)ncc1C(=O)N[C@H]1CC[C@H](C(C)(C)O)CC1 CHEMBL3915404 IC50 2.1 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC12CC3CC(CC(O)(C3)C1)C2 CHEMBL4110124 IC50 2.1 nM
CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCN(CC(N)=O)CC3)cc2O1 CHEMBL4483551 Ki 2.1 nM
COc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(Br)c2cc1C(N)=O CHEMBL4536517 IC50 2.1 nM
CC1(C)Cc2cc(NC(=O)c3coc(-c4ccnc(N)c4)n3)c(N3CCC(CO)CC3)cc2O1 CHEMBL5394332 IC50 2.1 nM
Cc1cc(Nc2ncc(-c3nc4ccccc4s3)c(NC3C[C@H](C(C)(C)O)[C@@H](O)[C@H]3O)n2)cc(C)n1 CHEMBL3353201 IC50 2.2 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@@H]1CCC[C@H]1O CHEMBL4114949 IC50 2.2 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1cccc(O)c1 CHEMBL4107137 IC50 2.2 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CCOCC1 CHEMBL4115033 IC50 2.2 nM
CC(C)(C)Cn1cc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1 CHEMBL4112374 IC50 2.2 nM
CC(C)(F)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)F)c1 CHEMBL4115485 IC50 2.2 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@@H]1COC[C@H]1O CHEMBL4115149 IC50 2.2 nM
CC(C)Nc1cc(-n2ccc3cc(CNC(=O)Cc4ccccc4)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4107665 IC50 2.2 nM
Cn1cc(-c2ccc(Nc3cc(-n4ncc5cc(C#N)cnc54)ncc3C(=O)NC[C@@H](F)C(C)(C)O)cc2)cn1 CHEMBL4108172 IC50 2.2 nM
CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ncc4cc(C#N)c(N)nc43)cc2N[C@H]2CCCC[C@@H]2F)CC1 CHEMBL3919786 IC50 2.2 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NCC(F)(F)F CHEMBL4109217 IC50 2.3 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)NC(C)C CHEMBL4113092 IC50 2.3 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@](O)(c2ccnn2C)CC1 CHEMBL3940719 IC50 2.3 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(O)C(C)C CHEMBL4115189 IC50 2.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(Cl)cnc32)cc1Nc1cnn(CC(F)F)c1 CHEMBL4106743 IC50 2.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(F)cnc32)cc1Nc1cnn(CC(F)F)c1 CHEMBL4109920 IC50 2.3 nM
CC(O)CCNc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4115108 IC50 2.3 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCC(=O)N1CCN(C)CC1 CHEMBL3931002 IC50 2.3 nM
CC(C)CC(=O)NCc1cnc2c(ccn2-c2cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn2)c1 CHEMBL4107848 IC50 2.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CCC(F)(F)C1 CHEMBL4108659 IC50 2.3 nM
CC(C)Nc1c(-c2cn(CCCO)nn2)cnc2sc(-c3cncs3)cc12 CHEMBL4761018 IC50 2.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC[C@@H](F)C(C)(C)O CHEMBL4112912 IC50 2.4 nM
C[C@@H](CF)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL3904382 IC50 2.4 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@H]1CC[C@H](O)CC1 CHEMBL4115100 IC50 2.4 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC(C)NS(C)(=O)=O CHEMBL3922475 IC50 2.4 nM
CC(Nc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O)C(F)(F)F CHEMBL4107426 IC50 2.4 nM
CCn1cc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1 CHEMBL4106715 IC50 2.4 nM
CC(C)(F)Cn1cc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1 CHEMBL4109952 IC50 2.4 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(CCCF)c1 CHEMBL4108464 IC50 2.4 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1cnn(C2CCOCC2)c1 CHEMBL4107855 IC50 2.4 nM
CCOC(C)(C)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC(C)C CHEMBL4115629 IC50 2.4 nM
COc1cc2c(OC[C@H]3NC(=O)[C@@H]4[C@@H](C)[C@@H]43)nccc2cc1C(N)=O CHEMBL4084228 IC50 2.4 nM
CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4643871 IC50 2.4 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1NC1CC1 CHEMBL4642013 IC50 2.4 nM
CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(-c3cn[nH]c3)cc12 CHEMBL4749904 IC50 2.4 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1cccc(C(N)=O)c1 CHEMBL4110867 IC50 2.5 nM
CCNc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](C(C)(C)O)CC1 CHEMBL3921034 IC50 2.5 nM
CC(C)Nc1cc(-n2cnc3cnc(NCCO)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4109831 IC50 2.5 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCc1ccncc1 CHEMBL3954452 IC50 2.5 nM
CC(Cn1cc(Nc2cc(-n3cnc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1)OC(F)F CHEMBL4113184 IC50 2.5 nM
CCCn1cc(Nc2cc(-n3ncc4cc(Cl)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1 CHEMBL4109113 IC50 2.5 nM
CCCn1cc(Nc2cc(-n3cnc4cc(Cl)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1 CHEMBL4107733 IC50 2.5 nM
CC(C)(F)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(Cl)cnc32)cc1Nc1cnn(CC(F)F)c1 CHEMBL4112525 IC50 2.5 nM
CC(C)(F)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)F)c1 CHEMBL4111627 IC50 2.5 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1ccc2[nH]ncc2c1 CHEMBL4113337 IC50 2.5 nM
CC(C)Nc1cc(Nc2ccc3nsnc3c2)ncc1-c1nnc(C(=O)N2CC[C@@H](O)C2)s1 CHEMBL3906505 IC50 2.5 nM
O=c1[nH]c(NC2CCC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2cnccc2s1 CHEMBL4107142 IC50 2.5 nM
COc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(C#CCCCCCCCCCCOc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)c2cc1C(N)=O CHEMBL4445579 IC50 2.5 nM
Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCNC4)nc23)c(C(F)F)n1 CHEMBL3634506 IC50 2.5 nM
CN1CCN(c2cccc(Nc3ncc(-c4nc5ccccc5s4)c(NC4C[C@H](CO)[C@@H](O)[C@H]4O)n3)c2)CC1 CHEMBL3353200 IC50 2.6 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@H](F)C(C)(C)O CHEMBL3947755 IC50 2.6 nM
CC(C)(O)CNc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4112926 IC50 2.6 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL3948538 IC50 2.6 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1CCN(C)CC1 CHEMBL3931392 IC50 2.6 nM
COCCn1cc(Nc2cc(-n3ncc4cc(Cl)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1 CHEMBL4107529 IC50 2.6 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(Cl)cnc32)cc1Nc1cnn(CCCF)c1 CHEMBL4109034 IC50 2.6 nM
CC(F)Cn1cc(Nc2cc(-n3cnc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1 CHEMBL4109898 IC50 2.6 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1Nc1ccc2nc[nH]c2c1 CHEMBL4112058 IC50 2.6 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cccc(C#N)c1 CHEMBL4114850 IC50 2.6 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1ccc(C#N)cc1 CHEMBL4111578 IC50 2.6 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1ccc2ncsc2c1 CHEMBL4113432 IC50 2.6 nM
CCCNc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4107116 IC50 2.6 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)c(N)nc32)cc1NC12CC3CC(CC(O)(C3)C1)C2 CHEMBL4115542 IC50 2.6 nM
CC1(C)Cc2cc(NC(=O)c3coc(-c4ccnc(N)c4)n3)c(N3CCOCC3)cc2O1 CHEMBL5425478 IC50 2.6 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCCc1ccc(S(N)(=O)=O)cc1 CHEMBL3914563 IC50 2.7 nM
CC(C)Nc1cc(-n2ncc3cc(Cl)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4109623 IC50 2.7 nM
CC1(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)CC1 CHEMBL4111088 IC50 2.7 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(Cl)cnc32)cc1Nc1cnn(CCC#N)c1 CHEMBL4109280 IC50 2.7 nM
CC(C)Nc1cc(-n2ccc3cc(CNC(=O)CC(C)(C)C)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4115268 IC50 2.7 nM
C[C@@H](F)CNc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4113645 IC50 2.7 nM
Cc1sc(-c2cnc(Nc3ccc4ncsc4c3)cc2NC(C)C)nc1C(=O)NCCCN1CCCCC1 CHEMBL3925654 IC50 2.7 nM
CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nc(C(N)=O)co1 CHEMBL3913888 IC50 2.7 nM
COc1cc2c(OC[C@H]3NC(=O)C[C@H]3C)nccc2cc1C(N)=O CHEMBL4070515 IC50 2.7 nM
O=C(Nc1cc2oc(N3CCOCC3)nc2cc1N1CCCCC1)c1cccc(-c2cn[nH]c2)n1 CHEMBL4760206 IC50 2.7 nM
CC(C)n1ccc2nc(Nc3ccc4cnn(C(C)C)c4c3)nc(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)c21 CHEMBL5178313 IC50 2.7 nM
CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nnc(C(=O)N2CC[C@H](O)C2)s1 CHEMBL3353196 IC50 2.8 nM
O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1[C@H]1CC[C@H](O)CC1)c1cccc([N+](=O)[O-])c1 CHEMBL3735673 Ki 2.8 nM
O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1-c1ccccc1)c1cccc(C(F)(F)F)c1 CHEMBL3736278 Ki 2.8 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NCC1(O)CCC1 CHEMBL4112750 IC50 2.8 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCC(=O)NC1CCS(=O)(=O)C1 CHEMBL3921524 IC50 2.8 nM
COC[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC(C)C CHEMBL4108617 IC50 2.8 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@](O)(c2ccncc2)CC1 CHEMBL3974716 IC50 2.8 nM
COC(C)(C)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC(C)C CHEMBL4110810 IC50 2.8 nM
CC[C@@H](C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4114010 IC50 2.8 nM
CC(C)(F)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(Cl)cnc32)cc1Nc1cnn(C(F)F)c1 CHEMBL4108814 IC50 2.8 nM
C[C@@H](Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O)C1CC1 CHEMBL4109005 IC50 2.8 nM
CCCOC(=O)NCc1cnc2c(ccn2-c2cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn2)c1 CHEMBL4113892 IC50 2.8 nM
CCCNc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4112023 IC50 2.8 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC12CCC(O)(CC1)C2 CHEMBL4111058 IC50 2.8 nM
CC(C)(O)[C@H]1CC[C@H](Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)C1 CHEMBL3980538 IC50 2.8 nM
CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nnc(C(=O)N2CCC(O)C2)s1 CHEMBL3934248 IC50 2.8 nM
Nc1ccc(-c2cccc(C(=O)Nc3cc4oc(N5CCOCC5)nc4nc3N3CCCCC3)n2)cn1 CHEMBL4743091 IC50 2.8 nM
CC(CF)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4110348 IC50 2.9 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CC1 CHEMBL4110250 IC50 2.9 nM
CCn1cc(Nc2cc(-n3cnc4cc(Cl)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1 CHEMBL4109693 IC50 2.9 nM
CCCn1cc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1 CHEMBL4113237 IC50 2.9 nM
CC(=O)N1CC[C@@H](Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)C1 CHEMBL4109546 IC50 2.9 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@@H]1CCN(C(=O)CC#N)C1 CHEMBL4112814 IC50 2.9 nM
Clc1ccc2ncn(-c3cccc(NC4CCNCC4)n3)c2c1 CHEMBL436653 IC50 3.0 nM
Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCC(F)(F)C[C@@H]4N)nc23)c(C(F)(F)F)n1 CHEMBL3590491 IC50 3.0 nM
Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CC(F)(F)CC[C@@H]4N)nc23)c(C(F)(F)F)n1 CHEMBL3590492 IC50 3.0 nM
Cc1cc(Nc2ncc(-c3nc4cnccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)ccn1 CHEMBL3601071 IC50 3.0 nM
Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CC(F)(F)CC[C@@H]4N)nn23)c(C(F)F)n1 CHEMBL3634501 IC50 3.0 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CCC(F)CC1 CHEMBL4109402 IC50 3.0 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)F CHEMBL4111152 IC50 3.0 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@H]1CCOC1 CHEMBL3984663 IC50 3.0 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CN(S(C)(=O)=O)C1 CHEMBL4113763 IC50 3.0 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCC(N)C1 CHEMBL4110735 IC50 3.0 nM
Cn1nnnc1-c1ccc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cc1 CHEMBL4108900 IC50 3.0 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CCN(c2ncc(F)cn2)CC1 CHEMBL4108818 IC50 3.0 nM
CC(C)(F)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC12CC3CC(CC(O)(C3)C1)C2 CHEMBL4112867 IC50 3.0 nM
COc1cc2nc(NCCO)ccc2cc1NC(=O)c1cnn2cccnc12 CHEMBL3979633 IC50 3.0 nM
N#Cc1ccc2ncnc(N[C@H]3CC[C@H](N4CCC(F)(F)CC4)CC3)c2c1 CHEMBL4069200 IC50 3.0 nM
N#Cc1ccc2ncnc(N[C@H]3CC[C@H](N4CCC(F)CC4)CC3)c2c1 CHEMBL4096446 IC50 3.0 nM
N#Cc1ccc2ncnc(N[C@H]3CC[C@H](N4CCN(S(=O)(=O)C5CC5)CC4)CC3)c2c1 CHEMBL4060511 IC50 3.0 nM
COC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnc4[nH]cc(C5CCOCC5)c34)CC2)CC1 CHEMBL4067181 IC50 3.0 nM
CN(C)C(=O)N1CCN([C@H]2CC[C@H](Nc3ncnc4[nH]cc(C5CCOCC5)c34)CC2)CC1 CHEMBL4104802 IC50 3.0 nM
CN(C)[C@H]1CC[C@H](Nc2ncnc3[nH]cc(C4CCC4)c23)CC1 CHEMBL4078625 IC50 3.0 nM
Cc1cnc(Nc2cccc(C(=O)N3CCCC3)c2)nc1N[C@H]1[C@@H](C(N)=O)[C@@H]2C=C[C@H]1C2 CHEMBL5076447 IC50 3.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2ccnc(F)c2)[C@H]2C=C[C@@H]1C2 CHEMBL5094640 IC50 3.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc3ccsc23)[C@H]2C=C[C@@H]1C2 CHEMBL5185144 IC50 3.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3ccc(F)c(C(=O)N4CCCC4)c3)nc3ccsc23)[C@H]2C=C[C@@H]1C2 CHEMBL5175590 IC50 3.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc3ccoc23)[C@H]2C=C[C@@H]1C2 CHEMBL5192205 IC50 3.0 nM
Cc1n[nH]c2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)c12 CHEMBL5183959 IC50 3.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc3ncsc23)[C@H]2C=C[C@@H]1C2 CHEMBL5187663 IC50 3.0 nM
CN1C[C@@H]2C[C@H]1C[C@@H]2n1cc(Nc2nc(NC3(C)CC3)c3c(=O)n(C)ccc3n2)cn1 CHEMBL5187604 IC50 3.0 nM
CN1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(C(F)F)ccc4n3)cn2)CC1 CHEMBL5189582 IC50 3.0 nM
C[C@H](F)Cn1ccc2nc(Nc3cnn([C@H]4C[C@H]5C[C@@H]4CN5C)c3)nc(NC3(C)CC3)c2c1=O CHEMBL5177080 IC50 3.0 nM
COC(=O)N1CCN([C@H]2CC[C@H](Nc3nc(Nc4cnn(C)c4)nc4ccc(CC#N)nc34)CC2)CC1 CHEMBL4582624 IC50 3.0 nM
CC(=O)N1CCC(n2cc(Nc3nc(OC4CCOCC4)c4nc(C)ccc4n3)cn2)CC1 CHEMBL5272567 IC50 3.0 nM
Cc1ccc2nc(Nc3cnn(C4CCN(C)CC4)c3)nc(OC3(C)CC3)c2n1 CHEMBL5274369 IC50 3.0 nM
CN1CCC(n2cc(Nc3nc(OC4(C)CC4)c4nc(-c5cnn(C)c5)ccc4n3)cn2)CC1 CHEMBL5266181 IC50 3.0 nM
Cc1ncc(-c2nc3c(OC4(C)CC4)nc(Nc4cnn(C5CCN(C)CC5)c4)nc3cc2F)cn1 CHEMBL5288931 IC50 3.0 nM
Cc1ncc(-c2nc3c(OC4(C)CC4)nc(Nc4cnn(C5CC6(C5)CN(C)C6)c4)nc3cc2F)cn1 CHEMBL5270903 IC50 3.0 nM
CN1CC2(CC(n3cc(Nc4nc(OC5(C)CC5)c5nc(C6CC6)c(F)cc5n4)cn3)C2)C1 CHEMBL5285779 IC50 3.0 nM
Cc1nc2c(OC3(C)CC3)nc(Nc3cnn(C4CC5(C4)CN(C)C5)c3)nc2cc1F CHEMBL5286869 IC50 3.0 nM
NC(=O)c1nn(CCO)cc1NC(=O)c1ccc2cnc(NC3CCCCC3N)nn12 CHEMBL5283042 IC50 3.0 nM
CNC(=O)c1nn(C)cc1NC(=O)c1ccc2cnc(NCCN)nn12 CHEMBL5266171 IC50 3.0 nM
CN1CCN(C(=O)Cn2cc3cc(NC(=O)c4cccc(C(F)(F)F)n4)c(OCC4CC4)cc3n2)CC1 CHEMBL5406696 IC50 3.0 nM
CC(C)(O)CCNC(=O)c1cnc(-n2ccc3cc(Cl)cnc32)cc1NC1CCOCC1 CHEMBL3890249 IC50 3.1 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(Cl)cnc32)cc1NC1CC1 CHEMBL4107169 IC50 3.1 nM
CC(C)Nc1cc(-n2ncc3cc(O)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4111012 IC50 3.1 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCc1ccc(S(N)(=O)=O)cc1 CHEMBL3890756 IC50 3.1 nM
COC(C)(C)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)c(N)nc32)cc1NC(C)C CHEMBL4114108 IC50 3.1 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1ccn(CC(F)F)n1 CHEMBL4110422 IC50 3.1 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCN(c2ccccc2)CC1 CHEMBL4113871 IC50 3.1 nM
CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nc(C(=O)NCCCN2CCCC2)cs1 CHEMBL3905639 IC50 3.1 nM
CC(C)CCNc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4112445 IC50 3.2 nM
COCCn1cc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1 CHEMBL4113624 IC50 3.2 nM
CCCC(=O)NCc1cnc2c(ccn2-c2cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn2)c1 CHEMBL4112394 IC50 3.2 nM
CCNc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4110619 IC50 3.2 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CCC(N)C1 CHEMBL4109707 IC50 3.2 nM
CNC(=O)c1ccc(Nc2cc(Nc3ccc4ncsc4c3)ncc2-c2nnc(C(=O)N3CC[C@@H](O)C3)s2)cc1 CHEMBL3935695 IC50 3.2 nM
CC1(C)Cc2cc(NC(=O)c3cnn4cc(O)cnc34)c(N3CCOCC3)cc2O1 CHEMBL4466092 Ki 3.2 nM
CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCC(C(N)=O)CC3)cc2O1 CHEMBL4461516 Ki 3.2 nM
CC(C)Nc1cc(Nc2ccn3nccc3n2)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4641090 IC50 3.2 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)ccc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4109437 IC50 3.3 nM
CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2N[C@@H](C)CO)CC1 CHEMBL3938824 IC50 3.3 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](O)CC1 CHEMBL3958699 IC50 3.3 nM
C[C@H](CF)Nc1cc(-n2ccc3cncnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4108187 IC50 3.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NCC(F)(F)C(C)(C)O CHEMBL4112724 IC50 3.3 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@](F)(c2ccnn2C)CC1 CHEMBL3893606 IC50 3.3 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCc1ccc(F)cc1 CHEMBL3986533 IC50 3.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(C2CCOCC2)c1 CHEMBL4110171 IC50 3.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(Cl)cnc32)cc1Nc1cnn(CCC#N)c1 CHEMBL4115117 IC50 3.3 nM
Cn1cc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1 CHEMBL4111561 IC50 3.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CC1c1c[nH]cn1 CHEMBL4115463 IC50 3.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cccc(C#N)c1F CHEMBL4108684 IC50 3.3 nM
CC(C)(O)[C@H]1CC[C@H](Nc2cc(-n3ncc4cc(Cl)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)C1 CHEMBL3930748 IC50 3.3 nM
CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ncc4cc(C#N)c(N)nc43)cc2N[C@@H]2CCCC[C@H]2F)CC1 CHEMBL4112444 IC50 3.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@H]1CC[C@H](NC(=O)C(F)F)CC1 CHEMBL4107389 IC50 3.3 nM
CC(=O)NC1CCN(C(=O)c2nnc(-c3cnc(Nc4ccc5ncsc5c4)cc3NC(C)C)s2)C1 CHEMBL3907736 IC50 3.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(Cl)cnc32)cc1NC1CCC1 CHEMBL4113064 IC50 3.4 nM
CC(C)Nc1cc(-n2ccc3cnc(N(C)C)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4107163 IC50 3.4 nM
CC[C@@H](C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC(C)(C)O CHEMBL4107281 IC50 3.4 nM
COC1CCC(NC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC(C)C)CC1 CHEMBL3954925 IC50 3.4 nM
COc1ccc(CCNC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC(C)C)cc1 CHEMBL3944928 IC50 3.4 nM
CC(C)(F)CCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC(C)(C)C CHEMBL3910109 IC50 3.4 nM
CC(C)CCNC(=O)c1cnc(-n2ncc3cc(C#N)c(N)nc32)cc1NC1COC1 CHEMBL3980604 IC50 3.4 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(F)cnc32)cc1NC1CCC(F)C1 CHEMBL4113443 IC50 3.4 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)c(N)nc32)cc1NC1CC1 CHEMBL4110746 IC50 3.4 nM
CC(C)Nc1cc(Nc2nc3ccnn3cc2F)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4634922 IC50 3.4 nM
CC(C)Nc1cc(Nc2ncc(Cl)cc2F)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL3353193 IC50 3.5 nM
CS(=O)(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2NC2CCOCC2)CC1 CHEMBL3973807 IC50 3.5 nM
CC(=O)N[C@H]1CC[C@H](NC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC(C)C)CC1 CHEMBL3925644 IC50 3.5 nM
COC1CCC(O)(CCNC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC(C)C)CC1 CHEMBL3923198 IC50 3.5 nM
CC(C)CCNC(=O)c1cnc(-n2ncc3cc(C#N)c(N)nc32)cc1NC(C)C CHEMBL3907387 IC50 3.5 nM
CC1(Nc2cc(-n3cnc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)CC1 CHEMBL4113284 IC50 3.5 nM
CC(C)n1cc(Nc2cc(-n3ncc4cc(Cl)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1 CHEMBL4109253 IC50 3.5 nM
CCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)F)c1 CHEMBL3920482 IC50 3.5 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1COCC1(F)F CHEMBL4108188 IC50 3.5 nM
CC(C)CCC(=O)NCc1cnc2c(ccn2-c2cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn2)c1 CHEMBL4113859 IC50 3.5 nM
CC(C)(O)c1cnc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)s1 CHEMBL4111235 IC50 3.5 nM
CNC(=O)CN1CCN(c2cc3c(cc2NC(=O)c2cnn4cccnc24)CC(C)(C)O3)CC1 CHEMBL4438027 Ki 3.5 nM
CC(C)Nc1cc(Nc2ccc3nsnc3c2)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4645407 IC50 3.5 nM
Cc1cc(-c2nc(C(=O)Nc3cc4oc(N5CCOCC5)nc4nc3N3CCC(O)CC3)co2)ccn1 CHEMBL4750630 IC50 3.5 nM
Cc1cc(C#N)cnc1Nc1cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn1 CHEMBL3353192 IC50 3.6 nM
CNC(=O)c1cccc(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)c1 CHEMBL4107577 IC50 3.6 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@H]1CC[C@](C)(O)CC1 CHEMBL4114551 IC50 3.6 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](S(C)(=O)=O)CC1 CHEMBL3947754 IC50 3.6 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@](O)(c2cccnc2)CC1 CHEMBL3969520 IC50 3.6 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCC(F)C1(O)COC1 CHEMBL3951199 IC50 3.6 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1(O)CCCC1 CHEMBL3922334 IC50 3.6 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCc1ccc(N(C[SH](=O)=O)S(C)(=O)=O)cc1 CHEMBL3923791 IC50 3.6 nM
CC(C)Nc1cc(-n2cnc3cnc(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)F CHEMBL4111656 IC50 3.6 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cc(-c2ccccc2)n[nH]1 CHEMBL4114476 IC50 3.6 nM
CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2O1 CHEMBL4473269 IC50 3.6 nM
O=C(Nc1cc2oc(N3CCOCC3)nc2nc1N1CCCCC1)c1coc(N2CC[C@H](O)C2)n1 CHEMBL4796558 IC50 3.6 nM
Cc1cc(-c2nc(C(=O)Nc3cc4oc(N5CCOCC5)nc4nc3N3CCC(F)CC3)co2)ccn1 CHEMBL4784665 IC50 3.6 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NCC1COC1 CHEMBL4111055 IC50 3.7 nM
CC(C)Nc1cc(-n2cnc3cnc(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4113937 IC50 3.7 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@](O)(c2ccccn2)CC1 CHEMBL3899111 IC50 3.7 nM
CCOC(C)(C)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC(C)C CHEMBL4108910 IC50 3.7 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](C(C)(C)O)C1 CHEMBL3984250 IC50 3.7 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1ccc(-n2cncn2)cc1 CHEMBL4107103 IC50 3.7 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1COC1 CHEMBL4114375 IC50 3.7 nM
O=c1[nH]c(N2CCN(c3cccnc3)CC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1 CHEMBL4109600 IC50 3.7 nM
COc1cc2c(OC[C@H]3NC(=O)[C@H](C)[C@H]3C)nccc2cc1C(N)=O CHEMBL4061801 IC50 3.7 nM
CC(=O)N[C@H]1CC[C@H](NC(=O)c2cnc3sc(-c4cncs4)cc3c2NC(C)C)CC1 CHEMBL4754408 IC50 3.7 nM
O=C(Nc1nc2cc(CN3CCOCC3)ccc2n1[C@H]1CC[C@H](O)CC1)c1cccc([N+](=O)[O-])c1 CHEMBL3735523 Ki 3.8 nM
CC(=O)N[C@H]1CC[C@H](NC(=O)c2cnc(-n3ncc4cc(C#N)c(N)nc43)cc2NC(C)C)CC1 CHEMBL3983043 IC50 3.8 nM
C[C@@H](F)CNc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4108028 IC50 3.8 nM
CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(-c3ccc(=O)[nH]c3)cc12 CHEMBL4762550 IC50 3.8 nM
CS(=O)(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2Nc2cccc(C(N)=O)c2)CC1 CHEMBL3985083 IC50 3.9 nM
CC(F)[C@H](C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL3933400 IC50 3.9 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC1CCC(C(C)(O)C2CC2)CC1 CHEMBL3914855 IC50 3.9 nM
CC(C)Nc1cc(-n2ncc3cnc(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4106938 IC50 3.9 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@H]1CC[C@H](NC(=O)c2ccccc2F)CC1 CHEMBL4112863 IC50 3.9 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 3.981 nM
CCc1ccc2nc(Nc3cc(Cc4ccccc4)nc(N[C@H]4CC[C@H](O)CC4)n3)sc2c1 CHEMBL2441273 pIC50 3.981 nM
N#Cc1ccc2ncc(-c3cccc(NC4CCNCC4)n3)n2c1 CHEMBL255873 IC50 4.0 nM
Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCC[C@@H]4O)nc23)c(C(F)F)n1 CHEMBL3590486 IC50 4.0 nM
Cc1cc(Nc2ncc(-c3nc(-c4ccccc4)cs3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc(C)n1 CHEMBL3601185 IC50 4.0 nM
CN(C)c1ccc(Nc2ncc(-c3nc4cnccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc1 CHEMBL3601072 IC50 4.0 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1cc2cc[nH]c2cn1 CHEMBL3910394 IC50 4.0 nM
CC(C)Nc1cc(-n2cnc3cc(Cl)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4115184 IC50 4.0 nM
CCCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)F)c1 CHEMBL3971510 IC50 4.0 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NCCN1CCOCC1 CHEMBL4106614 IC50 4.0 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CCN(c2ccccc2)CC1 CHEMBL4112812 IC50 4.0 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@H]1CC[C@H](C(C)(C)O)CC1 CHEMBL4112293 IC50 4.0 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@H]1CC[C@@](C)(O)CC1 CHEMBL4115045 IC50 4.0 nM
O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1csc(-n2ccnc2)n1 CHEMBL4111400 IC50 4.0 nM
NCC1CCN(c2cc(C(=O)Nc3ccccc3)ccc2NC(=O)c2cnn3cccnc23)CC1 CHEMBL3920056 IC50 4.0 nM
c1nc(S[C@H]2CC[C@H](N3CCOCC3)CC2)c2c(C3CCOCC3)c[nH]c2n1 CHEMBL4087063 IC50 4.0 nM
CNC(=O)c1cnc(Nc2ccc3[nH]ncc3c2)cc1N[C@@H](c1ccccc1)[C@H](O)CO CHEMBL4101382 IC50 4.0 nM
CN(C)[C@H]1CC[C@H](Nc2ncnc3[nH]cc([C@H]4CC[C@H](C(N)=O)CC4)c23)CC1 CHEMBL4279192 IC50 4.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2ccccc2F)[C@H]2C=C[C@@H]1C2 CHEMBL5088588 IC50 4.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc3[nH]ncc23)[C@H]2C=C[C@@H]1C2 CHEMBL5198583 IC50 4.0 nM
Cn1ccc2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)c21 CHEMBL5181320 IC50 4.0 nM
Cn1ncc2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)c21 CHEMBL5175829 IC50 4.0 nM
CN1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(C5CC5)ccc4n3)cn2)CC1 CHEMBL5193495 IC50 4.0 nM
C[C@@H](CF)n1ccc2nc(Nc3cnn(C4CCN(C)CC4)c3)nc(NC3(C)CC3)c2c1=O CHEMBL5188816 IC50 4.0 nM
CN1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(-c5cncnc5)ccc4n3)cn2)CC1 CHEMBL5191035 IC50 4.0 nM
CN1C[C@H]2C[C@@H]1C[C@@H]2n1cc(Nc2nc(NC3(C)CC3)c3c(=O)n(CC(F)F)ccc3n2)cn1 CHEMBL5184407 IC50 4.0 nM
CN1CC2(CC(n3cc(Nc4nc(NC5(C)CC5)c5c(=O)n(CC(F)F)ccc5n4)cn3)C2)C1 CHEMBL5178692 IC50 4.0 nM
Cc1ncc(-c2nc3c(OC4(C)CC4)nc(Nc4cnn([C@@H]5C[C@@H]6C[C@H]5CN6C)c4)nc3cc2F)cn1 CHEMBL5290338 IC50 4.0 nM
CC(C)Oc1cc2nn(CC(=O)N3CCN(C)CC3)cc2cc1NC(=O)c1cccc(C(F)(F)F)n1 CHEMBL5396130 IC50 4.0 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCCNS(C)(=O)=O CHEMBL3946114 IC50 4.1 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC1CCC2(CC1)NC(=O)NC2=O CHEMBL3925452 IC50 4.1 nM
CC(C)Nc1cc(-n2ncc3cc(Cl)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4112570 IC50 4.1 nM
CC(Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O)C(F)(F)F CHEMBL4107224 IC50 4.1 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1CC1 CHEMBL3952777 IC50 4.1 nM
CCn1nnnc1-c1ccc(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cc1 CHEMBL4112477 IC50 4.1 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@@H]1CCN(C(=O)CC(F)(F)F)C1 CHEMBL4113034 IC50 4.1 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@@H]1CCOC1 CHEMBL4111056 IC50 4.1 nM
C[C@H](F)CNc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL3933904 IC50 4.1 nM
CC[C@@H](CO)Nc1cc(-n2ncc3cc(Cl)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL3896654 IC50 4.1 nM
CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1C(=O)NCCC(C)(C)O CHEMBL4649875 IC50 4.1 nM
CC(C)n1ncc2ccc(Nc3nc(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)c4c(ccn4C)n3)cc21 CHEMBL5200765 IC50 4.1 nM
CC(C)Nc1cc(-n2ccc3cncnc32)ncc1C(=O)NCCC(C)(C)O CHEMBL3969623 IC50 4.2 nM
CC(C)Nc1cc(-n2ncc3cc(Br)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4106606 IC50 4.2 nM
CC(C)Nc1cc(-n2ccc3cccnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4110704 IC50 4.3 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@](F)(c2nccn2C)CC1 CHEMBL3982704 IC50 4.3 nM
CC(C)Nc1cc(-n2ncc3cc(Cl)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)F CHEMBL4111778 IC50 4.3 nM
CC(C)n1cc(Nc2cc(-n3cnc4cc(Cl)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1 CHEMBL4112222 IC50 4.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCC(NCC(F)(F)F)C1 CHEMBL4114212 IC50 4.3 nM
CC(C)Nc1cc(-n2ccc3cc(CNC(=O)CC4CCCC4)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4110095 IC50 4.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CC(F)(F)C1 CHEMBL4113934 IC50 4.3 nM
CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1C(=O)NCC(F)(F)C(C)(C)O CHEMBL4648202 IC50 4.3 nM
CC(C)n1ncc2ccc(Nc3nc(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)c4c(ccn4C(F)F)n3)cc21 CHEMBL5193503 IC50 4.3 nM
COc1cccc(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)c1 CHEMBL4111310 IC50 4.4 nM
CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cncnc43)cc2NC2CCOCC2)CC1 CHEMBL3911840 IC50 4.4 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCCC(F)(F)C1O CHEMBL4108104 IC50 4.4 nM
C[C@@H](CF)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCCC(C)(C)O CHEMBL3914423 IC50 4.4 nM
C[C@H](Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O)C1CC1 CHEMBL3977735 IC50 4.4 nM
CS(=O)(=O)NCCNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CC1 CHEMBL3921676 IC50 4.4 nM
CC[C@@H](CO)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL3910622 IC50 4.4 nM
CCNc1cc(-n2ccc3cc(C(N)=O)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4110658 IC50 4.5 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(Cl)cnc32)cc1NC1CCOCC1 CHEMBL4107578 IC50 4.5 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CCC1 CHEMBL4112884 IC50 4.5 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1ccc(N2CCOCC2)nc1 CHEMBL3905289 IC50 4.5 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCc1nc(Cc2ccccc2)no1 CHEMBL3898909 IC50 4.5 nM
CC(C)CCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC(C)C CHEMBL3924274 IC50 4.5 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1CCOCC1 CHEMBL3986782 IC50 4.5 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(C#N)cnc32)cc1NC1CCC1 CHEMBL4112848 IC50 4.5 nM
COc1cc(-c2nc(C(=O)Nc3cc4oc(N5CCOCC5)nc4nc3N3CCCCC3)co2)ccn1 CHEMBL4763990 IC50 4.5 nM
Cc1c[nH]c2ncnc(N[C@H]3CC[C@H](N(C)C)CC3)c12 CHEMBL4063689 pIC50 4.571 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@](C)(O)CC1 CHEMBL3911745 IC50 4.6 nM
C[C@H](CF)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4107902 IC50 4.6 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](NS(C)(=O)=O)CC1 CHEMBL3916631 IC50 4.6 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(F)cnc43)cc2NC2CC2)CC1 CHEMBL3977557 IC50 4.6 nM
CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)nccc2cc1C(N)=O CHEMBL4092338 IC50 4.6 nM
CNC(=O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CC1 CHEMBL4115518 IC50 4.7 nM
CC(C)Nc1cc(-n2ccc3cnc(N4CC[C@@H](O)C4)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4108854 IC50 4.7 nM
CC(C)(CO)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4110079 IC50 4.7 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCc1cccnc1 CHEMBL3949690 IC50 4.7 nM
CC[C@H](C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL3967712 IC50 4.7 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCc1c[nH]cn1 CHEMBL3955423 IC50 4.7 nM
C[C@@H](CO)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCCNS(C)(=O)=O CHEMBL3917759 IC50 4.7 nM
CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1N[C@@H](c1ccccc1)[C@H](O)CO CHEMBL4075955 IC50 4.7 nM
CC(C)c1c[nH]c2ncnc(N[C@H]3CC[C@H](N(C)C)CC3)c12 CHEMBL4085735 pIC50 4.786 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C(N)=O)cnc32)cc1NC1CCC1 CHEMBL4114139 IC50 4.8 nM
CC(C)Nc1cc(-n2ccc3cnc(N4CC[C@H](O)C4)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL3949060 IC50 4.8 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC(C)(C)NS(C)(=O)=O CHEMBL3891636 IC50 4.8 nM
CC(C)c1cc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)[nH]n1 CHEMBL4107677 IC50 4.8 nM
CC(C)(O)/C=C/Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4107316 IC50 4.8 nM
CC(C)Nc1cc(-n2ccc3cc(CNC(=O)OC(C)C)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4114483 IC50 4.8 nM
CC(C)(F)CCNc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4112418 IC50 4.8 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@@H]1C[C@H]1CO CHEMBL3982186 IC50 4.8 nM
COc1cc2c(OC[C@H]3NC(=O)[C@@H]4C[C@H]34)nccc2cc1C(N)=O CHEMBL4075552 IC50 4.8 nM
CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2sc(-c3ccncc3)cc12 CHEMBL4756721 IC50 4.8 nM
CC(=O)N[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cncnc43)cc2NC2CCOCC2)CC1 CHEMBL3978710 IC50 4.9 nM
COC(=O)N[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2NC(C)C)CC1 CHEMBL3932139 IC50 4.9 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCN1CCOCC1 CHEMBL3942383 IC50 4.9 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCC(F)C1CCOCC1 CHEMBL3950330 IC50 4.9 nM
Cn1cc(Nc2cc(-n3ncc4cc(Cl)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1 CHEMBL4113759 IC50 4.9 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1N[C@@H]1COC[C@H]1F CHEMBL4108427 IC50 4.9 nM
NC(=O)c1ccc2ncc(-c3cccc(NC4CCNCC4)n3)n2c1 CHEMBL403358 IC50 5.0 nM
Cc1ccc(-n2nc(N3CCN(C)CC3)cc2NC(=O)c2cnn3cccnc23)nc1 CHEMBL3586510 IC50 5.0 nM
Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC[C@@H]4N)nn23)c(C(F)(F)F)n1 CHEMBL3634379 IC50 5.0 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@](O)(c2nccs2)CC1 CHEMBL3921623 IC50 5.0 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NCCC(F)(F)F CHEMBL4111939 IC50 5.0 nM
C[C@H]1C[C@@H](Nc2nc(N3CCOCC3)[nH]c(=O)c2-c2ccc3ccccc3n2)[C@H](O)[C@@H]1O CHEMBL3901315 IC50 5.0 nM
COc1ccc(N2CCN(c3nc(N[C@@H]4CCCNC4)c(-c4nc5ccccc5s4)c(=O)[nH]3)CC2)nc1 CHEMBL4115508 IC50 5.0 nM
N#Cc1ccc2sc(-c3c(N[C@@H]4CCCNC4)nc(N4CCOCC4)[nH]c3=O)nc2c1 CHEMBL4107459 IC50 5.0 nM
CC(O)C1CCN(c2ccc(Cl)cc2NC(=O)c2cnn3cccnc23)CC1 CHEMBL3890299 IC50 5.0 nM
CNC(=O)c1cnc(Nc2ccc3c(c2)CC(=O)N3)cc1N[C@@H](c1ccccc1)[C@H](O)CO CHEMBL4065667 IC50 5.0 nM
CNC(=O)c1cnc(Nc2ccc(C#N)cc2)cc1N[C@@H](c1ccccc1)[C@H](O)CO CHEMBL4059465 IC50 5.0 nM
COC(=O)N1CCN([C@H]2CC[C@H](Nc3nc(Nc4cnn(C)c4)nc4ccc(C#N)nc34)CC2)CC1 CHEMBL4556866 IC50 5.0 nM
Cc1cc(-c2nc(C(=O)Nc3cc4oc(N5CCOCC5)nc4nc3N3CCCCC3)co2)ccn1 CHEMBL4790506 IC50 5.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2ccsc2)[C@H]2C=C[C@@H]1C2 CHEMBL5079990 IC50 5.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2-c2cncc(F)c2)[C@H]2C=C[C@@H]1C2 CHEMBL5079737 IC50 5.0 nM
CN1CCN(C(=O)c2cccc(Nc3ncc(-c4cccc(F)c4)c(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)n3)c2)CC1 CHEMBL5087788 IC50 5.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc3[nH]cnc23)[C@H]2C=C[C@@H]1C2 CHEMBL5208062 IC50 5.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc3ccccc23)[C@H]2C=C[C@@H]1C2 CHEMBL5178272 IC50 5.0 nM
Cc1n[nH]c2nc(Nc3cc(F)cc(N4CCOCC4)c3)nc(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)c12 CHEMBL5207689 IC50 5.0 nM
COC(=O)N1CCN([C@H]2CC[C@H](Nc3nc(Nc4cnn(C)c4)nc4ccc(C)nc34)CC2)CC1 CHEMBL4521212 IC50 5.0 nM
COC(=O)N1CCN([C@H]2CC[C@H](Nc3nc(Nc4cnn(C)c4)nc4ccn(C)c(=O)c34)CC2)CC1 CHEMBL5173450 IC50 5.0 nM
CC(C)n1ccc2nc(Nc3cnn(C4CCN(C)CC4)c3)nc(NC3(C)CC3)c2c1=O CHEMBL5205770 IC50 5.0 nM
C[C@H](CF)n1ccc2nc(Nc3cnn(C4CCN(C)CC4)c3)nc(NC3(C)CC3)c2c1=O CHEMBL5193438 IC50 5.0 nM
Cc1ncncc1-c1ccc2nc(Nc3cnn(C4CCN(C)CC4)c3)nc(OC3(C)CC3)c2n1 CHEMBL5270136 IC50 5.0 nM
CCOc1cc2nn(CC(=O)N3CCN(C)CC3)cc2cc1NC(=O)c1cccc(C(F)(F)F)n1 CHEMBL5426529 IC50 5.0 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 5.012 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H]([N+](=O)[O-])CC1 CHEMBL3970825 IC50 5.1 nM
C[C@H](CF)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCCC(C)(C)O CHEMBL4110597 IC50 5.1 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1ccc(N2CCOCC2)cc1 CHEMBL3923977 IC50 5.1 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC1CCN(S(=O)(=O)C(C)C)CC1 CHEMBL3966110 IC50 5.1 nM
CC(C)CCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1COC1 CHEMBL3956976 IC50 5.1 nM
C[C@]1(CO)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2O1 CHEMBL4466517 Ki 5.1 nM
C[C@@H](CF)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL3981034 IC50 5.2 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCCNS(=O)(=O)N1CCOCC1 CHEMBL3907139 IC50 5.2 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@H]1CC[C@H](NC2COC2)CC1 CHEMBL4113585 IC50 5.2 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@H]1CC[C@H](NC(=O)C2CC2)CC1 CHEMBL4114030 IC50 5.2 nM
CC(C)Nc1cc(Nc2ccn3nccc3c2)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4641886 IC50 5.2 nM
CC(C)Nc1c(-c2cn(CCCO)nn2)cnc2sc(-c3ccc(=O)[nH]c3)cc12 CHEMBL4789541 IC50 5.2 nM
CC(C)Nc1cc(Nc2ncc(C#N)cn2)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL3353194 IC50 5.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(Cl)cnc32)cc1NC1CC1 CHEMBL4113223 IC50 5.3 nM
CC(C)Nc1cc(-n2ncc3cc(F)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4111435 IC50 5.3 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@](F)(c2nccs2)CC1 CHEMBL3912832 IC50 5.3 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1ccc(N2CCNCC2)nc1 CHEMBL3895880 IC50 5.3 nM
CC(O)CCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC(C)C CHEMBL3916413 IC50 5.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCCC(CO)C1 CHEMBL4108787 IC50 5.3 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC1CCN(C[SH](=O)=O)CC1 CHEMBL3900602 IC50 5.3 nM
CCCCNC(=O)c1cnc(-n2ncc3cc(C#N)c(N)nc32)cc1NC1COC1 CHEMBL3951721 IC50 5.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NCCCF CHEMBL4108324 IC50 5.3 nM
CC(C)(F)CCNc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4110610 IC50 5.3 nM
CCOC(=O)NCc1cnc2c(ccn2-c2cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn2)c1 CHEMBL4115180 IC50 5.4 nM
CC(C)Nc1cc(-n2ccc3cc(CNC(=O)CC4CCCCC4)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4106835 IC50 5.4 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCCCOC(C)(C)C CHEMBL3947682 IC50 5.5 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@@H]1CC=C(c2ccncc2)CC1 CHEMBL4110687 IC50 5.5 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1COCC1(F)F CHEMBL4106712 IC50 5.5 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(Nc2ccc3cnccc3n2)cc1NC1CC1 CHEMBL3352825 IC50 5.6 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCCCOC(C)C CHEMBL3908695 IC50 5.6 nM
CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ncc4cc(Cl)cnc43)cc2NC(C)C)CC1 CHEMBL3914366 IC50 5.6 nM
CC(C)CCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@@H](C)CO CHEMBL3922192 IC50 5.6 nM
CC(C)(O)[C@H]1CCC[C@@H](Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)C1 CHEMBL3919364 IC50 5.6 nM
CS(=O)(=O)N1CC2(CN(c3nc(N[C@@H]4C[C@H](CO)[C@@H](O)[C@H]4O)c(-c4nc5ccccc5s4)c(=O)[nH]3)C2)C1 CHEMBL4112534 IC50 5.6 nM
O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc(-c2ccc(F)cc2)cs1 CHEMBL4115519 IC50 5.6 nM
CC1(CNc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)COC1 CHEMBL4109689 IC50 5.7 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(C#N)cnc32)cc1Nc1cnn(C(F)F)c1 CHEMBL4110222 IC50 5.7 nM
CS(=O)(=O)NCCNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC1CCOCC1 CHEMBL3954359 IC50 5.7 nM
CC(C)COC(=O)NCc1cnc2c(ccn2-c2cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn2)c1 CHEMBL4112197 IC50 5.7 nM
Cc1nccc2sc(-c3c(N[C@@H]4CCCNC4)nc(N4CCOCC4)[nH]c3=O)nc12 CHEMBL4107242 IC50 5.7 nM
CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1C(=O)NCCc1ccc(S(N)(=O)=O)cc1 CHEMBL4636136 IC50 5.7 nM
COc1cc(NC(=O)c2cccc(C(F)(F)F)n2)cc2cn(C3CCN(C)CC3)nc12 CHEMBL4764582 IC50 5.7 nM
CC(=O)N1CC(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)C1 CHEMBL4112117 IC50 5.8 nM
CC(C)(C)CNc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4114915 IC50 5.8 nM
CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCCC(O)CC3)cc2O1 CHEMBL4531013 Ki 5.8 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1(O)CCC(C)(O)CC1 CHEMBL3927317 IC50 5.9 nM
CCS(=O)(=O)N1CCC(NC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC(C)C)CC1 CHEMBL3934549 IC50 5.9 nM
CC(C)CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4112226 IC50 5.9 nM
CCCNC(=O)NCc1cnc2c(ccn2-c2cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn2)c1 CHEMBL4111603 IC50 5.9 nM
COc1cc2c(OC[C@@H]3CCC(=O)N3)ccnc2cc1C(N)=O CHEMBL4061890 IC50 5.9 nM
Clc1ccc2ncc(-c3cccc(NC4CNC4)n3)n2c1 CHEMBL256963 IC50 6.0 nM
COc1ccc2ncc(-c3cccc(NC4CCNCC4)n3)n2c1 CHEMBL402629 IC50 6.0 nM
O=c1[nH]c(N2CCN(c3cccnc3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1 CHEMBL3353202 IC50 6.0 nM
COCc1nn(C)cc1NC(=O)c1cnn2ccc(N[C@@H]3CCCC[C@@H]3N)nc12 CHEMBL3590476 IC50 6.0 nM
Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCCC[C@@H]4N)nc23)c(-c2nnco2)n1 CHEMBL3590481 IC50 6.0 nM
Cn1cc(NC(=O)c2cnn3ccc(N4CC[C@H](F)[C@@H](N)C4)nc23)c(C(F)(F)F)n1 CHEMBL3590517 IC50 6.0 nM
OC[C@H]1C[C@@H](Nc2nc(Nc3cncnc3)ncc2-c2nc3ccncc3s2)[C@H](O)[C@@H]1O CHEMBL3601078 IC50 6.0 nM
CC(C)(O)CCNC(=O)c1cnc(-n2ccc3cncnc32)cc1NC1CCOCC1 CHEMBL3894977 IC50 6.0 nM
[C-]#[N+]C1(NC(=O)c2cnc(-n3ncc4cc(C#N)c(N)nc43)cc2NC(C)C)CC1 CHEMBL3964003 IC50 6.0 nM
C[N+]1=C(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)CC=N1 CHEMBL4107861 IC50 6.0 nM
COc1ccnc(N2CCN(c3nc(N[C@@H]4CCCNC4)c(-c4nc5ccccc5s4)c(=O)[nH]3)CC2)c1 CHEMBL4108950 IC50 6.0 nM
CN(C)[C@H]1CC[C@H](Nc2ncnc3[nH]cc(C4CCOCC4)c23)CC1 CHEMBL4089379 IC50 6.0 nM
CN(C)[C@H]1CC[C@H](Nc2ncnc3[nH]cc(C4CCCC4)c23)CC1 CHEMBL4097418 IC50 6.0 nM
COC(=O)N1CCN([C@H]2CC[C@H](Nc3nc(Nc4cnn(C)c4)nc4ccc(C(C)C#N)nc34)CC2)CC1 CHEMBL4548760 IC50 6.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)ncc2C2CC2)[C@H]2C=C[C@@H]1C2 CHEMBL5090193 IC50 6.0 nM
CN1CCN(c2cc(Nc3ncc(-c4cccc(F)c4)c(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)n3)ccn2)CC1 CHEMBL5091192 IC50 6.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCOCC4)c3)nc3ccsc23)[C@H]2C=C[C@@H]1C2 CHEMBL5201935 IC50 6.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc3cc[nH]c23)[C@H]2C=C[C@@H]1C2 CHEMBL5184745 IC50 6.0 nM
CN1CCC(n2cc(Nc3nc(NC4(C)CC4)c4c(=O)n(-c5cn(C)nn5)ccc4n3)cn2)CC1 CHEMBL5190559 IC50 6.0 nM
CCOc1cc2nn(CC(=O)N3CCN(C(=O)c4ccccc4)CC3)cc2cc1NC(=O)c1cccc(C(F)(F)F)n1 CHEMBL5427784 IC50 6.0 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1(O)CCOCC1 CHEMBL3925280 IC50 6.1 nM
CC(C)Nc1cc(-n2ccc3cc(CNC(=O)CC(C)(C)O)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4110685 IC50 6.1 nM
N#Cc1cc2cnn(-c3cc(NC4COC4)c(C(=O)NCCC4CC4)cn3)c2nc1N CHEMBL3891376 IC50 6.1 nM
CC(F)CCNc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4109670 IC50 6.1 nM
CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2C1O CHEMBL4439292 Ki 6.1 nM
CC1(C)Cc2cc(NC(=O)c3cnn4cc(C#N)cnc34)c(N3CCOCC3)cc2O1 CHEMBL4456286 Ki 6.1 nM
C[C@@H](CF)Nc1cc(-n2ccc3cncnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL3928854 IC50 6.2 nM
CC(C)Nc1cc(-n2ncc3cncnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4108811 IC50 6.2 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC(=O)N1CCN(C)CC1 CHEMBL3898994 IC50 6.2 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](NC(=O)[C@H](C)O)CC1 CHEMBL3903828 IC50 6.2 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1(O)CC1 CHEMBL3916358 IC50 6.2 nM
CC(C)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)F)c1 CHEMBL3938766 IC50 6.2 nM
Cc1cc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)[nH]n1 CHEMBL4113185 IC50 6.2 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ncc4cc(Cl)cnc43)cc2NC2COC2)CC1 CHEMBL3943289 IC50 6.2 nM
O=c1[nH]c(N2CCC(c3cncnc3)CC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1 CHEMBL4112396 IC50 6.2 nM
CCCCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC(C)C CHEMBL3930830 IC50 6.3 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](C(C)(C)O)C1 CHEMBL3908035 IC50 6.3 nM
CC(C)Nc1cc(-n2ncc3cc(Cl)cnc32)ncc1C(=O)NCC(F)C1(O)COC1 CHEMBL3927743 IC50 6.3 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NCCC1CC1 CHEMBL3985063 IC50 6.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CN(c2ncc(F)cn2)C1 CHEMBL4106523 IC50 6.3 nM
O=C(Nc1nc2cc(F)ccc2n1[C@H]1CC[C@H](CO)CC1)c1cccc([N+](=O)[O-])c1 CHEMBL3735044 Ki 6.4 nM
CCNc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4109995 IC50 6.4 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@](O)(c2nccn2C)CC1 CHEMBL3898331 IC50 6.4 nM
CC(C)NC(=O)[C@H]1CC[C@H](Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)CC1 CHEMBL4108546 IC50 6.4 nM
O=C(Nc1nc2cc(F)ccc2n1[C@H]1CC[C@H](O)CC1)c1cccc([N+](=O)[O-])c1 CHEMBL3734846 Ki 6.5 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1CCCOC1 CHEMBL4108784 IC50 6.5 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC(C)(C)O CHEMBL3923273 IC50 6.5 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1CCCCO1 CHEMBL3953023 IC50 6.5 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1(O)CCC(F)(F)CC1 CHEMBL3902784 IC50 6.5 nM
CCCCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@@H](C)CO CHEMBL3894173 IC50 6.5 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(Cl)cnc32)cc1Nc1cnn(C2CCOCC2)c1 CHEMBL4108001 IC50 6.5 nM
O=c1[nH]c(N2CC3(CNC3)C2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1 CHEMBL4114620 IC50 6.5 nM
CC1(C)Cc2cc(NC(=O)c3cnn4cc(CO)cnc34)c(N3CCOCC3)cc2O1 CHEMBL4518559 Ki 6.5 nM
CCC1(O)CCCN(c2nc3nc(N4CCOCC4)oc3cc2NC(=O)c2coc(-c3ccnc(C)c3)n2)C1 CHEMBL4777409 IC50 6.5 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC1CCCCC1 CHEMBL3978447 IC50 6.6 nM
CC(C)(O)C(F)(F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)F)c1 CHEMBL3937950 IC50 6.6 nM
CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCN(CCO)CC3)cc2O1 CHEMBL4584820 Ki 6.6 nM
CC(=O)OC(C)(C)C(=O)NCCNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC(C)C CHEMBL3949459 IC50 6.7 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1cnc(N2CCOCC2)nc1 CHEMBL3938325 IC50 6.7 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1(O)CCOC1 CHEMBL3944351 IC50 6.7 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)c(N)nc32)ncc1C(=O)NC1(C)CC1 CHEMBL3892469 IC50 6.7 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C(N)=O)cnc32)cc1NCC1CNC1 CHEMBL4108062 IC50 6.7 nM
CC(C)(CNc1cc(-n2ncc3cc(Cl)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O)OC(F)F CHEMBL4112958 IC50 6.7 nM
O=C(Nc1cc2[nH]cnc2cc1N1CCC(CO)CC1)c1cnn2cccnc12 CHEMBL4554579 Ki 6.7 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ccc3cc(C#N)cnc32)cc1NC(CO)CF CHEMBL4115333 IC50 6.8 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](S(C)(=O)=O)CC1 CHEMBL3953510 IC50 6.8 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1ccc(CN2CCOCC2)cc1 CHEMBL3954291 IC50 6.8 nM
COC1CCN(c2ccc(NC(=O)c3cnc(-n4ncc5cc(C#N)cnc54)cc3NC(C)C)cn2)CC1 CHEMBL3931480 IC50 6.8 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@@H]1CCN(c2ncccn2)C1 CHEMBL4108523 IC50 6.8 nM
CCOC(=O)N1CC(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)C1 CHEMBL4106902 IC50 6.8 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cncnc32)cc1NC1CC1 CHEMBL4107673 IC50 6.9 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1ccc(N(C)C)nc1 CHEMBL3900811 IC50 6.9 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(Cl)cnc32)cc1N[C@@H]1C[C@H]1CO CHEMBL3951794 IC50 6.9 nM
CS(=O)(=O)N1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4c(C5CC5)nccc4s3)c(=O)[nH]2)CC1 CHEMBL4111648 IC50 6.9 nM
COc1ccc2ncc(-c3cccc(NC4CNC4)n3)n2c1 CHEMBL403433 IC50 7.0 nM
Cn1cc(-c2ccc3ncc(-c4cccc(NC5CCNCC5)n4)n3c2)cn1 CHEMBL255446 IC50 7.0 nM
Cc1ccc(-n2nc(C3CCN(C(C)C)CC3)cc2NC(=O)c2cnn3cccnc23)nc1 CHEMBL3586509 IC50 7.0 nM
COc1cc(Nc2ncc(-c3nc4cnccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)ccn1 CHEMBL3601075 IC50 7.0 nM
Cc1cnc2c(cnn2-c2cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn2)c1 CHEMBL4112161 IC50 7.0 nM
CC(CCF)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4111866 IC50 7.0 nM
Cc1cc(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)n(C)n1 CHEMBL4109108 IC50 7.0 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC2COC2)CC1 CHEMBL3976033 IC50 7.0 nM
O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1csc(-c2ccccc2)n1 CHEMBL4108981 IC50 7.0 nM
O=C(Nc1cc2cccnc2cc1O[C@H]1CC[C@@H](O)CC1)c1csc2cncnc12 CHEMBL3967068 IC50 7.0 nM
N#Cc1ccc2ncnc(N[C@H]3CC[C@H](N4CCOCC4)CC3)c2c1 CHEMBL4070214 IC50 7.0 nM
CN(C)[C@H]1CC[C@H](Nc2ncnc3ccc(C#N)cc23)CC1 CHEMBL4083650 IC50 7.0 nM
CCCCNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1NC(C)C CHEMBL4632511 IC50 7.0 nM
CN1CCN(c2cc(Nc3nc(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)c4sccc4n3)ccn2)CC1 CHEMBL5188095 IC50 7.0 nM
Cc1ncc(-c2ccc3nc(Nc4cnn(C5CCN(C)CC5)c4)nc(OC4(C)CC4)c3n2)c(C)n1 CHEMBL5270356 IC50 7.0 nM
CCNc1cc(-n2ccc3cc(Cl)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4107964 IC50 7.1 nM
CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2NC2CCOCC2)CC1 CHEMBL3954007 IC50 7.1 nM
CC(=O)N[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2NC2CCOCC2)CC1 CHEMBL3962798 IC50 7.1 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)N[C@@H]1CC[C@@H](C(C)(C)O)OC1 CHEMBL4108191 IC50 7.1 nM
CCOCCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1Nc1cnn(CC(F)F)c1 CHEMBL3910846 IC50 7.1 nM
O=c1[nH]c(N2CCc3ccccc3C2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1 CHEMBL3622516 IC50 7.2 nM
CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2S1(=O)=O CHEMBL4537890 IC50 7.2 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1ccc(N2CCN(C)CC2)cn1 CHEMBL3970192 IC50 7.3 nM
COC(=O)N1CC(Nc2cc(-n3ncc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)C1 CHEMBL4109155 IC50 7.3 nM
CC(C)(O)[C@]1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2O1 CHEMBL4576141 Ki 7.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(C#N)cnc32)cc1NC1CCOCC1 CHEMBL4112539 IC50 7.4 nM
CN1CCC2(CC1)Cc1cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc1O2 CHEMBL4524886 Ki 7.4 nM
CC1(C)Cc2cc(NC(=O)c3coc(-c4ccnc(N)c4)n3)c(N3CCN(CCO)CC3)cc2O1 CHEMBL5430303 IC50 7.4 nM
NC(=O)C[C@H]1CCc2sc3ncnc(O[C@H]4CC[C@H](N5CCOCC5)CC4)c3c21 CHEMBL3361254 Ki 7.5 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NCCNC(=O)C(C)(C)O CHEMBL3922141 IC50 7.5 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1(O)CCNC1 CHEMBL3940416 IC50 7.5 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NCC1CC1 CHEMBL4113245 IC50 7.5 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4109047 IC50 7.6 nM
COc1cc2c(OC[C@@H]3CCC(=O)N3)nccc2cc1C(N)=O CHEMBL4100091 IC50 7.6 nM
Cc1cc(-c2nc(C(=O)Nc3cc4cn(CCN(C)C)nc4cc3C(C)(C)O)co2)ccn1 CHEMBL4745104 IC50 7.7 nM
Cn1cc(NC(=O)c2cnc3ccc(N[C@@H]4CCNC4)nn23)c(C(F)F)n1 CHEMBL4794821 IC50 7.7 nM
O=C(Nc1nc2cc(F)ccc2n1[C@H]1CC[C@@H](CO)C1)c1cccc([N+](=O)[O-])c1 CHEMBL3735247 Ki 7.8 nM
CS[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2NC(C)C)CC1 CHEMBL3948840 IC50 7.8 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1cnn(C2CN(S(C)(=O)=O)C2)c1 CHEMBL3932554 IC50 7.8 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2cnc3cc(Cl)cnc32)cc1Nc1cnn(C(F)F)c1 CHEMBL4113207 IC50 7.8 nM
CCCCNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC1COC1 CHEMBL3979646 IC50 7.8 nM
C[C@@H](CO)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1CC1 CHEMBL3909749 IC50 7.9 nM
COCCn1cc(Nc2cc(-n3cnc4cc(Cl)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)cn1 CHEMBL4107168 IC50 7.9 nM
COc1ccc(-c2ccc3ncc(-c4cccc(NC5CCNCC5)n4)n3c2)cn1 CHEMBL402361 IC50 8.0 nM
CCN(Cc1cc(Nc2nc(C)cn3c(-c4cn[nH]c4)cnc23)sn1)C(C)(C)CO CHEMBL1232515 IC50 8.0 nM
CCN(Cc1cc(Nc2nc(C)cn3c(-c4cn[nH]c4)cnc23)sn1)C(C)(C)CO CHEMBL1650533 IC50 8.0 nM
COc1cc2ncccc2cc1NC(=O)c1csc2cnc(N(C)CCN)nc12 CHEMBL3353220 IC50 8.0 nM
Cn1cc(NC(=O)c2cnn3ccc(N[C@H]4CCCC[C@H]4N)nc23)c(C(N)=O)n1 CHEMBL3590473 IC50 8.0 nM
COc1cc(Nc2ncc(-c3ccc4ccccc4n3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)ccn1 CHEMBL3601189 IC50 8.0 nM
[C-]#[N+]CC(=O)N1CCC(CCNC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC(C)C)CC1 CHEMBL3921909 IC50 8.0 nM
CC(=O)N1CCC(Nc2cc(-n3ccc4cc(C#N)cnc43)ncc2C(=O)NC[C@@H](F)C(C)(C)O)CC1 CHEMBL4108168 IC50 8.0 nM
O=c1[nH]c(N2CCN(c3ccccn3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1 CHEMBL4110364 IC50 8.0 nM
O=c1[nH]c(N2CCN(c3cnccn3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1 CHEMBL4110266 IC50 8.0 nM
O=c1[nH]c(N2CCN(c3ccc(Cl)cn3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1 CHEMBL4112990 IC50 8.0 nM
Cc1cc(N2CCN(c3nc(N[C@@H]4CCCNC4)c(-c4nc5ccccc5s4)c(=O)[nH]3)CC2)sn1 CHEMBL4111001 IC50 8.0 nM
Cc1cnccc1N1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1 CHEMBL4109650 IC50 8.0 nM
O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc2cc(Cl)ccc2s1 CHEMBL4108791 IC50 8.0 nM
O=C(Nc1cc2cccnc2cc1N1CCCCC1)c1cnn2ccccc12 CHEMBL3895793 IC50 8.0 nM
CS(=O)(=O)N1CCN([C@H]2CC[C@H](Nc3ncnc4ccc(C#N)cc34)CC2)CC1 CHEMBL4088745 IC50 8.0 nM
CN(C)[C@H]1CC[C@H](Nc2ncnc3[nH]cc(C4CCOC4)c23)CC1 CHEMBL4081502 IC50 8.0 nM
O=C(Nc1cc2cccnc2cc1N1CCCCC1)c1cnn2cccnc12 CHEMBL4569648 Ki 8.0 nM
Cc1nc2ccc(Nc3cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn3)cc2s1 CHEMBL4643371 IC50 8.0 nM
Nc1ccc(-c2cccc(C(=O)Nc3cc4oc(N5CCOCC5)nc4cc3N3CCCCC3)n2)cn1 CHEMBL4757687 IC50 8.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3ccnc(N4CCOCC4)c3)ncc2-c2cccc(F)c2)[C@H]2C=C[C@@H]1C2 CHEMBL5093825 IC50 8.0 nM
Cc1c[nH]c2nc(Nc3cccc(C(=O)N4CCCC4)c3)nc(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)c12 CHEMBL5177543 IC50 8.0 nM
Cn1cc(Nc2nc(NC3(C)CC3)c3c(=O)n(C)ccc3n2)cn1 CHEMBL5183067 IC50 8.0 nM
COc1cc2nn(CC(=O)N3CCOCC3)cc2cc1NC(=O)c1cccc(C(F)F)n1 CHEMBL5421749 IC50 8.0 nM
CC(C)NC(=O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC(C)C CHEMBL4111430 IC50 8.1 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCN1CCS(=O)(=O)CC1 CHEMBL3947585 IC50 8.1 nM
COc1cnc(N2CC[C@@H](Nc3cc(-n4ncc5cc(C#N)cnc54)ncc3C(=O)NC[C@@H](F)C(C)(C)O)C2)nc1 CHEMBL4115327 IC50 8.1 nM
O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1-c1ccccc1)c1cccc([N+](=O)[O-])c1 CHEMBL3735719 Ki 8.2 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](NC(=O)[C@@H](C)O)CC1 CHEMBL4108032 IC50 8.2 nM
CC(C)Nc1cc(-n2ccc3cc(CNC(=O)NCc4ccccc4)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4114411 IC50 8.2 nM
CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2NC2CC2)CC1 CHEMBL3894635 IC50 8.3 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1(O)CCN(C)CC1 CHEMBL3932579 IC50 8.3 nM
COc1cc(NC(=O)c2cccc(C(F)(F)F)n2)cc2cn(CCC(C)(C)O)nc12 CHEMBL4797475 IC50 8.3 nM
CNC(=O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cc(C#N)cnc43)cc2CCC(C)(C)O)CC1 CHEMBL3917746 IC50 8.4 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1ccc(N2CCOCC2)cn1 CHEMBL3973052 IC50 8.4 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NCC1(F)CCC1 CHEMBL4115287 IC50 8.4 nM
Cc1nccc2sc(-c3c(N[C@@H]4C[C@H](CO)[C@@H](O)[C@H]4O)nc(N4CCOCC4)[nH]c3=O)nc12 CHEMBL4112827 IC50 8.4 nM
O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc2cc(F)ccc2s1 CHEMBL4111712 IC50 8.4 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NCCC1(O)CCN(C2COC2)CC1 CHEMBL3983180 IC50 8.5 nM
CC(C)(CN)CNc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4112662 IC50 8.5 nM
CC(C)(O)[C@H]1CC[C@H](NC(=O)c2cnc(-n3ncc4cc(C#N)cnc43)cc2Nc2cnn(CC(F)F)c2)CC1 CHEMBL3918080 IC50 8.6 nM
CCCCNC(=O)NCc1cnc2c(ccn2-c2cc(NC(C)C)c(C(=O)NC[C@@H](F)C(C)(C)O)cn2)c1 CHEMBL4108657 IC50 8.6 nM
O=c1[nH]c(N2CCCCC2)nc(N[C@@H]2CCCNC2)c1-c1nc2c(C3CC3)nccc2s1 CHEMBL4110413 IC50 8.6 nM
CC(C)(O)CCn1cc2cc(NC(=O)c3cccc(C(F)(F)F)n3)c(C(C)(C)O)cc2n1 CHEMBL4782801 IC50 8.6 nM
CC(C)Nc1cc(-n2cnc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)F CHEMBL4113524 IC50 8.7 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@H]1CCOC1 CHEMBL3965205 IC50 8.7 nM
CC(C)Nc1cc(Nc2ccc3nonc3c2)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4649636 IC50 8.7 nM
Cn1cc(NC(=O)c2cnc3ccc(N4CCC[C@@H](N)C4)nn23)c(C(F)F)n1 CHEMBL4793398 IC50 8.7 nM
Cn1cc(-c2cc3c(cc2NC(=O)c2coc(-c4ccnc(N)c4)n2)CC(C)(C)O3)cn1 CHEMBL5405160 IC50 8.7 nM
CC(O)CCNc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4107049 IC50 8.8 nM
CN1CCC2(CCN(c3nc(N[C@@H]4C[C@H](CO)[C@@H](O)[C@H]4O)c(-c4nc5ccccc5s4)c(=O)[nH]3)CC2)C1=O CHEMBL4110192 IC50 8.8 nM
CO[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)ccc32)cc1NC(C)C CHEMBL3897707 IC50 8.9 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(=O)N1CCN(S(C)(=O)=O)CC1 CHEMBL4115604 IC50 8.9 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(F)cnc32)cc1NC1CCC(O)C1 CHEMBL4113269 IC50 8.9 nM
O=c1[nH]c(N2CC3(COC3)C2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1 CHEMBL4109337 IC50 8.9 nM
Clc1ccc2ncc(-c3cccc(NC4CCCNC4)n3)n2c1 CHEMBL256961 IC50 9.0 nM
CC(C)Nc1cc(-n2ncc3cc(Cl)cnc32)ncc1C(=O)N[C@H]1CC[C@H](C(C)(C)O)CC1 CHEMBL3948919 IC50 9.0 nM
O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2CCCNC2)c1-c1nc2c(C3CC3)nccc2s1 CHEMBL4107471 IC50 9.0 nM
O=c1[nH]c(N2CCN(c3cc(Cl)ccn3)CC2)nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1 CHEMBL4112572 IC50 9.0 nM
CS(=O)(=O)c1ccccc1N1CCN(c2nc(N[C@@H]3CCCNC3)c(-c3nc4ccccc4s3)c(=O)[nH]2)CC1 CHEMBL4112091 IC50 9.0 nM
COc1cc2ncccc2cc1NC(=O)c1cnn2cc(O)cnc12 CHEMBL3978719 IC50 9.0 nM
COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL281948 Kd apparent 9.0 nM
CN(C)[C@H]1CC[C@H](Nc2ncnc3ccc(C(F)(F)F)cc23)CC1 CHEMBL4101649 IC50 9.0 nM
CN(C)C(=O)C1CCN([C@H]2CC[C@H](Nc3ncnc4[nH]cc(C5CCOCC5)c34)CC2)CC1 CHEMBL4086115 IC50 9.0 nM
Cc1cc(-c2nc(C(=O)Nc3cc4oc(N5CCOCC5)nc4nc3N3CC[C@@H](F)C3)co2)ccn1 CHEMBL4757349 IC50 9.0 nM
Cn1cc(NC(=O)c2cnc3ccc(N[C@@H]4CCCCNC4)nn23)c(C(F)F)n1 CHEMBL4787247 IC50 9.0 nM
N#Cc1ccc(-c2cnc(Nc3cccc(C(=O)N4CCCC4)c3)nc2N[C@H]2[C@@H](C(N)=O)[C@@H]3C=C[C@H]2C3)cc1 CHEMBL5077968 IC50 9.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cc(F)cc(N4CCOCC4)c3)nc3ccn(C(F)F)c23)[C@H]2C=C[C@@H]1C2 CHEMBL5173098 IC50 9.0 nM
COc1cc2nn(CC(=O)N3CCOCC3)cc2cc1NC(=O)c1cccc([C@@H](O)C(F)(F)F)n1 CHEMBL5426360 IC50 9.0 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC1CCc2nc(N)sc2C1 CHEMBL3894101 IC50 9.1 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)Nc1ccc(OCCN(C)C)cn1 CHEMBL3901331 IC50 9.2 nM
CNC(=O)c1cnc(-n2ncc3cc(C#N)c(N)nc32)cc1NC(C)C CHEMBL3961524 IC50 9.2 nM
CC(C)Nc1cc(-n2ncc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)C CHEMBL4111593 IC50 9.2 nM
CC(=O)N[C@H]1CC[C@H](NC(=O)c2cnc(-n3ccc4cncnc43)cc2NC(C)C)CC1 CHEMBL3958009 IC50 9.3 nM
CCC(O)(CC)[C@H](F)CNC(=O)c1cnc(-n2ncc3cncnc32)cc1NC(C)C CHEMBL4115569 IC50 9.3 nM
CC[C@@H](F)CNc1cc(-n2ncc3cc(Cl)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4112464 IC50 9.3 nM
CC(C)(O)[C@@H](F)CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1NC1CC1 CHEMBL4645368 IC50 9.3 nM
Cn1cc(NC(=O)c2cnn3ccc(N4CCC[C@@H](N)C4)nc23)c(C(F)F)n1 CHEMBL4784487 IC50 9.3 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(F)cnc32)cc1NC1CC1 CHEMBL4113637 IC50 9.5 nM
O=c1[nH]c(N2CCOCC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1ccc2ccccc2n1 CHEMBL4110461 IC50 9.5 nM
CNC(=O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NC(C)C CHEMBL4110155 IC50 9.6 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1N[C@@H]1CCN(C(=O)c2ccc(F)cc2F)C1 CHEMBL4106997 IC50 9.6 nM
CC(C)(O)[C@H](F)CNC(=O)c1cnc(-n2ncc3cc(C#N)cnc32)cc1NCCNS(C)(=O)=O CHEMBL4112120 IC50 9.7 nM
CC(C)NC(=O)[C@H](F)CNc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4114127 IC50 9.9 nM
CC(C)Nc1cc(N2CCc3cc(C#N)cnc32)ncc1C(=O)NC[C@@H](F)C(C)(C)O CHEMBL4107885 IC50 9.9 nM