O=C(NC[C@H](NC(=O)c1c(Cl)cc(CCC(O)c2cccc(O)c2)cc1Cl)C(=O)O)c1cccs1 CHEMBL1221918 IC50 1.4 nM
CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1nc3cccc(C(=O)O)c3s1)C[C@H]2c1ccc(C#N)cc1 CHEMBL1094128 IC50 1.8 nM
CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ccc(-c3nnn[nH]3)cn1)C[C@H]2c1ccc(C#N)cc1 CHEMBL1098727 IC50 1.8 nM
CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ccc(C(=O)O)cn1)C[C@H]2c1ccc(C#N)cc1 CHEMBL1098726 IC50 2.5 nM
O=C(O)C1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c(C(F)(F)F)c2C(F)(F)F)CC1 CHEMBL337562 IC50 3.0 nM
C[C@H](NC(=O)c1cnc2n1[C@](C)(Cc1ccc(C#N)cc1)C(=O)N2c1cc(Cl)c(F)c(Cl)c1)C(=O)NC1(c2ccccn2)CC1 CHEMBL4530740 IC50 3.0 nM
CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1cc(C(=O)O)ccn1)C[C@H]2c1ccc(C#N)cc1 CHEMBL1094115 IC50 3.6 nM
CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1nc3cc(C(=O)O)ccc3o1)C[C@H]2c1ccc(C#N)cc1 CHEMBL1094127 IC50 4.0 nM
CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1nc3ccc(C(=O)O)cc3s1)C[C@H]2c1ccc(C#N)cc1 CHEMBL1098437 IC50 4.4 nM
CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1nc3cccc(C(=O)O)c3o1)C[C@H]2c1ccc(C#N)cc1 CHEMBL1095138 IC50 4.8 nM
O=C(O)C1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c(Cl)c2C(F)(F)F)CC1 CHEMBL139349 IC50 5.0 nM
COc1ccccc1Sc1ccc(/C=C/C(=O)N2CCC(C(=O)O)CC2)c(C(F)(F)F)c1C(F)(F)F CHEMBL336789 IC50 5.0 nM
Cn1ccc2cc(Sc3ccc(/C=C/C(=O)N4CCC(C(=O)O)CC4)c(C(F)(F)F)c3C(F)(F)F)ccc21 CHEMBL343390 IC50 5.0 nM
CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ncc(C(=O)O)s1)C[C@H]2c1ccc(C#N)cc1 CHEMBL1096088 IC50 5.0 nM
COc1ccccc1Sc1ccc(/C=C/C(=O)N2CCC(C(=O)O)CC2)c(C(F)(F)F)c1Cl CHEMBL139068 IC50 6.0 nM
Cn1ccc2cc(Sc3ccc(/C=C/C(=O)N4CCC(C(=O)O)CC4)c(Cl)c3Cl)ccc21 CHEMBL138185 IC50 6.0 nM
CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1nc3ccc(C(=O)O)cc3o1)C[C@H]2c1ccc(C#N)cc1 CHEMBL1095148 IC50 6.0 nM
CC(=O)N1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c(Cl)c2Cl)CC1 CHEMBL341999 IC50 7.0 nM
O=C(O)C1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c(Cl)c2Cl)CC1 CHEMBL139390 IC50 7.0 nM
COc1ccccc1Sc1ccc(/C=C/C(=O)N2CCC(C(=O)O)CC2)c(Cl)c1Cl CHEMBL140085 IC50 8.0 nM
COc1ccccc1Sc1ccc(/C=C/C(=O)N2CCOCC2)c(C(F)(F)F)c1Cl CHEMBL423725 IC50 8.0 nM
CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1cc(C(=O)O)ncn1)C[C@H]2c1ccc(C#N)cc1 CHEMBL1098760 IC50 8.0 nM
CC(C)c1ccccc1Sc1ccc(/C=C/C(=O)N2CCC(C(=O)O)CC2)c(Cl)c1Cl CHEMBL337322 IC50 10.0 nM
COc1ccccc1Sc1ccc(/C=C/C(=O)N2CCOCC2)c(Cl)c1Cl CHEMBL344897 IC50 10.0 nM
Cc1cc(N2C[C@@H](c3ccc(C#N)cc3)[C@]3(C2)C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)N3C)ncc1C(=O)O CHEMBL1099103 IC50 11.0 nM
CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ncc(C(=O)O)cn1)C[C@H]2c1ccc(C#N)cc1 CHEMBL1097733 IC50 11.0 nM
CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ccccn1)C[C@H]2c1ccc(C#N)cc1 CHEMBL1097384 IC50 11.0 nM
CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ccc(C#N)cn1)C[C@H]2c1ccc(C#N)cc1 CHEMBL1096039 IC50 11.0 nM
CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ccc(C#N)nc1)C[C@H]2c1ccc(C#N)cc1 CHEMBL1094753 IC50 12.0 nM
Cc1nc(N2C[C@@H](c3ccc(C#N)cc3)[C@]3(C2)C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)N3C)ccc1C(=O)O CHEMBL1098761 IC50 12.0 nM
CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ccc(C(=O)O)nn1)C[C@H]2c1ccc(C#N)cc1 CHEMBL1096053 IC50 13.0 nM
CCNC(=O)C1(Nc2nc(NC(C)c3ccc(Br)cc3)nc(N3CC4CC3CN4C(=O)c3cccc(C(F)(F)F)c3)n2)Cc2ccccc2C1 CHEMBL3298195 IC50 16.0 nM
CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(Cc1cc(C(=O)O)cs1)C[C@H]2c1ccc(C#N)cc1 CHEMBL214529 IC50 18.0 nM
CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1cnc(C(=O)O)cn1)C[C@H]2c1ccc(C#N)cc1 CHEMBL1098071 IC50 19.0 nM
CCNC(=O)C1(Nc2nc(NCCc3ccc(Cl)c(Cl)c3)nc(N3CC4CC3CN4S(=O)(=O)c3ccccc3OC(F)(F)F)n2)Cc2ccccc2C1 CHEMBL3298198 IC50 22.0 nM
CCNC(=O)C1(Nc2nc(NCCc3ccc(Cl)c(Cl)c3)nc(N3CC4CC3CN4C(=O)c3cccc(C(F)(F)F)c3)n2)Cc2ccccc2C1 CHEMBL3298197 IC50 23.0 nM
CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1nccc(C(=O)O)n1)C[C@H]2c1ccc(C#N)cc1 CHEMBL1094431 IC50 26.0 nM
C[C@]1(Cc2ccc(Br)cc2)NC(=O)N(c2cc(Cl)cc(Cl)c2)C1=O CHEMBL1221917 Kd 26.0 nM
CCN1/C(=C/C=C/C2=[N+](CCCCCC(=O)NCCCCNC(=O)C3(Nc4nc(NCCc5ccc(Cl)c(Cl)c5)nc(N5CC6CC5CN6S(=O)(=O)c5cccc(C(F)(F)F)c5)n4)Cc4ccccc4C3)c3ccc(S(=O)(=O)O)cc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21 CHEMBL3298661 IC50 28.0 nM
O=C(/C=C/c1ccc(Sc2ccc3c(c2)OCCO3)c(C(F)(F)F)c1)N1CCOCC1 CHEMBL136191 IC50 30.0 nM
O=C(c1cccc(C(F)(F)F)c1)N1CC2CC1CN2c1nc(NCCc2ccc(Cl)c(Cl)c2)nc(NC2(C(=O)O)Cc3ccccc3C2)n1 CHEMBL3298411 IC50 37.0 nM
CC(=O)N1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c(Cl)c2)CC1 CHEMBL275402 IC50 40.0 nM
CC(=O)N1CCN(C(=O)/C=C/c2ccc(Sc3ccccc3C(C)C)c([N+](=O)[O-])c2)CC1 CHEMBL19677 IC50 44.0 nM
O=C(O)C1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c(C(F)(F)F)c2)CC1 CHEMBL102030 IC50 50.0 nM
CC(=O)N1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c(C(F)(F)F)c2)CC1 CHEMBL138777 IC50 55.0 nM
CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ccnc(C(=O)O)c1)C[C@H]2c1ccc(C#N)cc1 CHEMBL1094116 IC50 56.0 nM
CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1nc(C(=O)O)co1)C[C@H]2c1ccc(C#N)cc1 CHEMBL1095137 IC50 58.0 nM
CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ccc(C#N)cc1)C[C@H]2c1ccc(C#N)cc1 CHEMBL1096040 IC50 60.0 nM
O=C(O)C1(Nc2nc(NCCc3ccc(Cl)c(Cl)c3)nc(N3CC4CC3CN4S(=O)(=O)c3cccc(C(F)(F)F)c3)n2)Cc2ccccc2C1 CHEMBL3298660 IC50 65.0 nM
O=C(NC[C@H](NC(=O)c1c(Cl)cc2c(c1Cl)CCN(C(=O)c1cc3ccccc3o1)C2)C(=O)O)c1cccs1 CHEMBL1222290 IC50 69.0 nM
COc1ccccc1Sc1ccc(/C=C/C(=O)N2CCOCC2)c(C)c1C CHEMBL343370 IC50 90.0 nM
CCN1/C(=C/C=C/C2=[N+](CCCCCC(=O)NCCCCNC(=O)C3(Nc4nc(NCCc5ccc(Cl)c(Cl)c5)nc(N5CC6CC5CN6C(=O)c5cccc(C(F)(F)F)c5)n4)Cc4ccccc4C3)c3ccc(S(=O)(=O)O)cc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21 CHEMBL3297752 IC50 100.0 nM
CC(=O)N1CCN(C(=O)/C=C/c2ccc(Sc3cccc(Cl)c3Cl)c([N+](=O)[O-])c2)CC1 CHEMBL130110 IC50 105.0 nM
CC(C)c1ccccc1SC1=CC=C(/C=C/C(=O)N2CCC(C(=O)O)CC2)C(F)C1F CHEMBL336265 IC50 115.0 nM
CCNC(=O)C1(Nc2nc(N[C@@H](C)c3ccc(Br)cc3)nc(N3CC4CC3CN4S(=O)(=O)c3ccccc3OC(F)(F)F)n2)Cc2ccccc2C1 CHEMBL3298196 IC50 117.0 nM
CC(=O)N1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c([N+](=O)[O-])c2)CC1 CHEMBL538164 IC50 139.0 nM
CC(=O)N1CCN(C(=O)/C=C/c2ccc(Sc3ccc(Cl)cc3Cl)c(Cl)c2)CC1 CHEMBL101416 IC50 140.0 nM
O=C(O)C1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c(Cl)c2)CC1 CHEMBL138860 IC50 145.0 nM
COc1ccccc1Sc1ccc(/C=C/C(=O)N2CCOCC2)cc1Cl CHEMBL138987 IC50 150.0 nM
CC(=O)OC(C)(C)/C=C/C(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@@H](C=C(O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C CHEMBL455056 IC50 180.0 nM
CCNC(=O)C1(Nc2nc(N[C@@H](C)c3ccccc3)nc(N3CC4CC3CN4C(=O)c3cccc(C(F)(F)F)c3)n2)Cc2ccccc2C1 CHEMBL3298406 IC50 180.0 nM
O=C(NC[C@H](NC(=O)c1c(Cl)cc2c(c1Cl)CCN(C(=O)c1cccc(Cl)c1)C2)C(=O)O)c1cccs1 CHEMBL1222021 IC50 240.0 nM
O=C(NC[C@H](NC(=O)c1c(Cl)cc2c(c1Cl)CCN(C(=O)c1ccc3ccoc3c1)C2)C(=O)O)c1cccs1 CHEMBL1222288 IC50 260.0 nM
COc1ccccc1Sc1ccc(/C=C/C(=O)N2CCC(C(=O)O)CC2)c(C(F)(F)F)c1 CHEMBL140234 IC50 265.0 nM
O=C(O)C1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c3ccccc23)CC1 CHEMBL140361 IC50 295.0 nM
CC(=O)OC(C)(C)/C=C/C(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@H](C[C@H](O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C CHEMBL507237 IC50 300.0 nM
O=C(c1cccc(C(F)(F)F)c1)N1CC2CC1CN2c1nc(NCCc2ccc(Cl)c(Cl)c2)nc(NC2Cc3ccccc3C2)n1 CHEMBL3298412 IC50 358.0 nM
O=C(NC[C@H](NC(=O)c1c(Cl)cc2c(c1Cl)CCN(C(=O)c1ccc(Cl)cc1)C2)C(=O)O)c1cccs1 CHEMBL1222022 IC50 430.0 nM
CCNC(=O)C1(Nc2nc(NCCc3ccccc3)nc(N3CC4CC3CN4C(=O)c3cccc(C(F)(F)F)c3)n2)Cc2ccccc2C1 CHEMBL3298409 IC50 488.0 nM
O=C(NC[C@H](NC(=O)c1c(Cl)cc2c(c1Cl)CCN(C(=O)c1ccc(Cl)cc1)C2)C(=O)O)c1ccccc1 CHEMBL1222132 IC50 550.0 nM
O=C(NC[C@H](NC(=O)c1c(Cl)cc2c(c1Cl)CCN(C(=O)c1ccc3c(c1)OCC3)C2)C(=O)O)c1cccs1 CHEMBL1222289 IC50 650.0 nM
CC(C)(O)/C=C/C(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@@H](C=C(O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C CHEMBL387737 IC50 950.0 nM