C[C@@]12Cc3[nH]nc(C(=O)Nc4cnn([C@H](c5ccccc5)[C@H]5CCCCS5(=O)=O)c4)c3C[C@@H]1C2(F)F CHEMBL3426309 Ki 0.09 nM
CN(C)CC[C@@H](c1ccccc1)n1cc(NC(=O)c2n[nH]c3cc(-c4cn[nH]c4)ccc23)cn1 CHEMBL3263053 Ki 0.1 nM
O=S(=O)(c1ccccc1)c1cc(Nc2cc(C3CCCC3)[nH]n2)nc(N[C@H]2CC[C@H](O)CC2)c1 CHEMBL3355737 Ki 0.17 nM
COc1ccc2nc(Nc3cc(Cc4ccccc4)nc(N[C@H]4CC[C@H](O)CC4)n3)sc2n1 CHEMBL2441275 pKi 0.1995 nM
CC1(C)CCc2c(C(=O)Nc3cnn([C@H](c4ccccc4)C4CCNCC4)c3)n[nH]c2C1 CHEMBL3298373 Ki 0.2 nM
C[C@@]12Cc3[nH]nc(C(=O)Nc4cnn([C@H](c5ccccc5)C5CCS(=O)(=O)CC5)c4)c3C[C@@H]1C2 CHEMBL3426308 Ki 0.2 nM
CC1(C)CCc2c(C(=O)Nc3cnn([C@H](c4ccccc4)C4CCCS(=O)(=O)C4)c3)n[nH]c2C1 CHEMBL3426302 Ki 0.2 nM
CC1(C)CCc2c(C(=O)Nc3cnn([C@H](c4ccccc4)C4CC[S+]([O-])CC4)c3)n[nH]c2C1 CHEMBL3426305 Ki 0.2 nM
CC(C)(O)[C@@H](c1ccccc1)n1cc(NC(=O)c2n[nH]c3cc(-c4cn[nH]c4)ccc23)cn1 CHEMBL3263055 Ki 0.23 nM
O[C@H]1CC[C@H](Nc2nc(Cc3ccccc3)cc(Nc3nc4cccnc4s3)n2)CC1 CHEMBL2441276 pKi 0.2512 nM
N#Cc1ccc2nc(Nc3cc(Cc4ccccc4)nc(N[C@H]4CC[C@H](O)CC4)n3)sc2c1 CHEMBL2441274 pKi 0.2512 nM
Cc1cnc(Nc2cc(S(=O)(=O)c3ccccc3)cc(N[C@H]3CC[C@H](O)CC3)n2)s1 CHEMBL3355728 Ki 0.27 nM
CCC(O)(CC)c1ccc2cc(-c3n[nH]c4cc(C(F)F)sc34)[nH]c2c1 CHEMBL2017556 IC50 0.3 nM
CC1(C)CCc2c(C(=O)Nc3cnn(C(c4ccccc4)C4CN(CCF)C4)c3)n[nH]c2C1 CHEMBL3287196 Ki 0.3 nM
CC12Cc3[nH]nc(C(=O)Nc4cnn(Cc5ccccc5)c4)c3CC1C2(F)F CHEMBL3426307 Ki 0.3 nM
CC1(C)CCc2c(C(=O)Nc3cnn([C@H](c4ccccc4)C4CCCCS4(=O)=O)c3)n[nH]c2C1 CHEMBL3426303 Ki 0.3 nM
CC1(C)CCc2c(C(=O)Nc3cnn([C@H](c4ccccc4)C4CCS(=O)(=O)CC4)c3)n[nH]c2C1 CHEMBL3426304 Ki 0.3 nM
O[C@H]1CC[C@H](Nc2nc(Cc3ccccc3)cc(Nc3nc4ccc(Cl)cc4s3)n2)CC1 CHEMBL2441271 pKi 0.3162 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4cnco4)s3)nc3cc(CN[C@@H](C)C(C)(C)C)ccc31)C2 CHEMBL4203077 IC50 0.34 nM
O=S(=O)(c1ccccc1)c1cc(Nc2cc(C3CCCCC3)[nH]n2)nc(N[C@H]2CC[C@H](O)CC2)c1 CHEMBL3355738 Ki 0.38 nM
Cc1ccc2nc(Nc3cc(Cc4ccccc4)nc(N[C@H]4CC[C@H](O)CC4)n3)sc2c1 CHEMBL2441270 pKi 0.3981 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4ccnc(NC)c4)s3)nc3ccccc31)C2 CHEMBL4219011 IC50 0.41 nM
CCN(CC)Cc1cc([C@H]2C[C@@H]2C(=O)Nc2nc3ccc(-c4cn[nH]c4)cc3s2)ccc1OC CHEMBL3086538 Ki 0.5 nM
CC1(C)CCc2c(C(=O)Nc3cnn([C@H](c4ccccc4)C4CCS(=O)(=O)C4)c3)n[nH]c2C1 CHEMBL3426301 Ki 0.5 nM
CC1(C)CCc2c(C(=O)Nc3cnn([C@@H](CS(C)(=O)=O)c4ccccc4)c3)n[nH]c2C1 CHEMBL3426306 Ki 0.5 nM
C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCOCC4)cc3)nc3[nH]cc(-c4ccncc4)c23)c1 CHEMBL4464404 IC50 0.5 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4cc[nH]c(=O)c4)s3)nc3ccccc31)C2 CHEMBL4206765 IC50 0.53 nM
O=C(Nc1cnn([C@@H](CO)c2ccccc2)c1)c1n[nH]c2cc(-c3cn[nH]c3)ccc12 CHEMBL3263050 Ki 0.56 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4ccnc(C)n4)s3)nc3ccccc31)C2 CHEMBL4214683 IC50 0.58 nM
CN(C)Cc1ccc(C2CC2C(=O)Nc2nc3ccc(-c4cn[nH]c4)cc3s2)cc1 CHEMBL3086535 Ki 0.6 nM
CCc1ccc2nc(Nc3cc(Cc4ccccc4)nc(N[C@H]4CC[C@H](O)CC4)n3)sc2c1 CHEMBL2441273 pKi 0.631 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4cnco4)s3)nc3cc(CN[C@H]4CC[C@H](O)CC4)ccc31)C2 CHEMBL4216529 IC50 0.64 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4ccnc(N)c4)s3)nc3ccccc31)C2 CHEMBL4207292 IC50 0.67 nM
CN(C)Cc1ccc([C@H]2C[C@@H]2C(=O)Nc2nc3ccc(-c4cn[nH]c4)cc3s2)cc1 CHEMBL3086536 Ki 0.7 nM
CN(C)CC[C@@H](c1ccccc1)n1cc(NC(=O)c2n[nH]c3c2CCC(C)(C)C3)cn1 CHEMBL3298371 Ki 0.7 nM
Cc1cccc([C@H](CCN(C)C)n2cc(NC(=O)c3n[nH]c4c3CCC(C)(C)C4)cn2)c1 CHEMBL3298375 Ki 0.7 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4cnco4)s3)nc3cc(CNCC(C)(C)CO)ccc31)C2 CHEMBL4215147 IC50 0.7 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4cnco4)s3)nc3cc(NC)ccc31)C2 CHEMBL4216187 IC50 0.72 nM
N#Cc1cccc(Cn2cc(NC(=O)c3n[nH]c4cc(-c5cn[nH]c5)ccc34)cn2)c1 CHEMBL3263036 Ki 0.8 nM
CC(C)(O)[C@H](c1ccccc1)n1cc(NC(=O)c2n[nH]c3cc(-c4cn[nH]c4)ccc23)cn1 CHEMBL3263054 Ki 0.8 nM
CN(C)C[C@@H](c1ccccc1)n1cc(NC(=O)c2n[nH]c3c2CCC(C)(C)C3)cn1 CHEMBL3298370 Ki 0.8 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4cnco4)s3)nc3ccccc31)C2 CHEMBL4211372 IC50 0.81 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(C(F)F)s3)nc3cc(CNCC(C)(C)CO)ccc31)C2 CHEMBL4202941 IC50 0.87 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4ccnc(N)n4)s3)nc3ccccc31)C2 CHEMBL4217959 IC50 0.92 nM
CN(C)CC[C@H](c1ccccc1)n1cc(NC(=O)c2n[nH]c3cc(-c4cn[nH]c4)ccc23)cn1 CHEMBL3263052 Ki 0.93 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4cnco4)s3)nc3cc(F)ccc31)C2 CHEMBL4208358 IC50 0.99 nM
CC(C)(O)Cn1/c(=N/C(=O)c2ccc(-c3cn[nH]c3)s2)[nH]c2cc(CNC3CCCCC3)ccc21 CHEMBL493928 IC50 1.0 nM
CC(C)(O)Cn1/c(=N/C(=O)c2ccc(-c3cn[nH]c3)s2)[nH]c2cc(CNCc3ccccc3)ccc21 CHEMBL493537 IC50 1.0 nM
CN(Cc1cccnc1)Cc1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3cn[nH]c3)s1)n2CC(C)(C)O CHEMBL521695 IC50 1.0 nM
CC(C)CNCc1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3cn[nH]c3)s1)n2CC(C)(C)O CHEMBL522871 IC50 1.0 nM
C[C@@H](NCc1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3cn[nH]c3)s1)n2CC(C)(C)O)C(C)(C)C CHEMBL494993 IC50 1.0 nM
C[C@@H](N(C)Cc1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3cn[nH]c3)s1)n2CC(C)(C)O)C(C)(C)C CHEMBL495181 IC50 1.0 nM
C[C@H](NCc1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3cn[nH]c3)s1)n2CC(C)(C)O)C(C)(C)C CHEMBL522328 IC50 1.0 nM
C[C@H](N(C)Cc1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3cn[nH]c3)s1)n2CC(C)(C)O)C(C)(C)C CHEMBL522711 IC50 1.0 nM
CC1COCC(C)N1Cc1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3cn[nH]c3)s1)n2CC(C)(C)O CHEMBL522682 IC50 1.0 nM
O[C@H]1CC[C@H](Nc2nc(Cc3ccccc3)cc(Nc3nc4ccccc4s3)n2)CC1 CHEMBL2441269 pKi 1.0 nM
CC[C@@H](c1ccccc1)n1cc(NC(=O)c2n[nH]c3cc(-c4cn[nH]c4)ccc23)cn1 CHEMBL3263049 Ki 1.0 nM
Cc1cc2[nH]c(-c3n[nH]c4c3C[C@@H]3C(F)(F)[C@]3(C)C4)nc2cc1N(C)C(=O)[C@H](C)N1CCOCC1 CHEMBL5087453 IC50 1.0 nM
COc1ccc(-c2cc(Nc3cc(S(=O)(=O)c4ccccc4)cc(N[C@H]4CC[C@H](O)CC4)n3)n[nH]2)cc1 CHEMBL3355732 Ki 1.2 nM
CN(C)CC[C@@H](c1cccc(Cl)c1)n1cc(NC(=O)c2n[nH]c3c2CCC(C)(C)C3)cn1 CHEMBL3298376 Ki 1.2 nM
C=CC(=O)N1CCC[C@@H](Oc2nc(Nc3ccc(N4CCN(CC)CC4)cc3)nc3[nH]cc(-c4cncc(NC)n4)c23)C1 CHEMBL4457018 IC50 1.3 nM
N#Cc1cccc(Cn2cc(NC(=O)c3n[nH]c4cc(-c5ccc(N)nc5)ccc34)cn2)c1 CHEMBL3263035 Ki 1.4 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(C#N)cc3)nc3cc(CN[C@@H](C)C(C)(C)C)ccc31)C2 CHEMBL4210857 IC50 1.5 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(C(F)F)s3)nc3cc(CN4CCOCC4)ccc31)C2 CHEMBL4218914 IC50 1.52 nM
CCc1ccc2nc(Nc3cc(Cc4ccccc4)nc(N[C@H]4CC[C@H](O)CC4)n3)sc2n1 CHEMBL2441277 pKi 1.585 nM
O=S(=O)(c1ccccc1)c1cc(Nc2cc(C3CCC3)[nH]n2)nc(N[C@H]2CC[C@H](O)CC2)c1 CHEMBL3355736 Ki 1.6 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccns3)nc3cc(CN[C@@H](C)C(C)(C)C)ccc31)C2 CHEMBL4215807 IC50 1.62 nM
O=C(Nc1cnc(Cc2ccccc2)s1)c1n[nH]c2ccccc12 CHEMBL3263039 Ki 1.7 nM
O=S(=O)(c1ccccc1)c1cc(Nc2cc(-c3ccc(F)cc3)[nH]n2)nc(N[C@H]2CC[C@H](O)CC2)c1 CHEMBL3355733 Ki 1.8 nM
CC(C)(O)c1ccc2cc(-c3n[nH]c4ccsc34)[nH]c2c1 CHEMBL2017552 IC50 1.9 nM
CN(C)Cc1cccc([C@H]2C[C@@H]2C(=O)Nc2nc3ccc(-c4cn[nH]c4)cc3s2)c1 CHEMBL3086537 Ki 1.9 nM
Cc1cnc(Nc2cc(Cc3ccccc3)nc(N[C@H]3CC[C@H](O)CC3)n2)s1 CHEMBL2441267 pKi 1.995 nM
CC(C)(O)Cn1/c(=N/C(=O)c2ccc(-c3cn[nH]c3)s2)[nH]c2cc(CNc3ccccc3)ccc21 CHEMBL493319 IC50 2.0 nM
CN(Cc1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3cn[nH]c3)s1)n2CC(C)(C)O)C1CCCCC1 CHEMBL522849 IC50 2.0 nM
CNCc1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3cn[nH]c3)s1)n2CC(C)(C)O CHEMBL494135 IC50 2.0 nM
CCC(C)NCc1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3cn[nH]c3)s1)n2CC(C)(C)O CHEMBL495026 IC50 2.0 nM
CN(C)CCN(C)Cc1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3cn[nH]c3)s1)n2CC(C)(C)O CHEMBL492990 IC50 2.0 nM
CC(C)(O)Cn1/c(=N/C(=O)c2ccc(-c3cn[nH]c3)s2)[nH]c2cc(CN3CCOCC3)ccc21 CHEMBL494027 IC50 2.0 nM
CC(C)(O)Cn1/c(=N/C(=O)c2ccc(-c3cn[nH]c3)s2)[nH]c2cc(CN3CCC(O)C3)ccc21 CHEMBL494743 IC50 2.0 nM
CN(C(=O)c1ccc(F)cc1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCC(N)=O CHEMBL483581 IC50 2.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(C=O)s1)n2CCC(N)=O CHEMBL482169 IC50 2.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3ccncc3)s1)n2CCC(N)=O CHEMBL519960 IC50 2.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3cnco3)s1)n2CCC(N)=O CHEMBL481884 IC50 2.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3cn[nH]c3)s1)n2CCC(N)=O CHEMBL481720 IC50 2.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3cncc(C#N)c3)s1)n2CCC(N)=O CHEMBL481900 IC50 2.0 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3cccc(C(=O)Nc4ccc(C(C)C)c(C)c4)c3)c3c(N)ncnc32)C1 CHEMBL2179805 IC50 2.0 nM
C[C@@H](C(=O)N(C)c1ccc2[nH]c(-c3n[nH]c4c3C[C@@H]3C[C@]3(C)C4)nc2c1)C1CCOCC1 CHEMBL5090091 IC50 2.0 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(C(C)(F)F)s3)nc3ccccc31)C2 CHEMBL4204572 IC50 2.17 nM
C=CC(=O)N1CCC[C@@H]1COc1nc(Nc2ccc(N3CCN(C(C)=O)CC3)cc2)nc2[nH]cc(-c3cncc(NC)n3)c12 CHEMBL4593230 IC50 2.2 nM
O=S(=O)(c1ccccc1)c1cc(Nc2cc(-c3ccccc3)[nH]n2)nc(N[C@H]2CC[C@H](O)CC2)c1 CHEMBL3355730 Ki 2.3 nM
C=CC(=O)N1CCC(Oc2nc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)nc3[nH]cc(-c4cncc(NC)n4)c23)CC1 CHEMBL4463563 IC50 2.3 nM
CCC(O)(CC)c1ccc2cc(-c3n[nH]c4ccsc34)[nH]c2c1 CHEMBL2017553 IC50 2.4 nM
COc1ccc([C@H]2C[C@@H]2C(=O)Nc2nc3ccc(-c4cn[nH]c4)cc3s2)cc1 CHEMBL3086533 Ki 2.5 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL1873475 IC50 2.7 nM
COCCCn1c(NC(=O)c2ccno2)nc2cc(CNc3ccccc3)ccc21 CHEMBL528989 IC50 3.0 nM
Cc1ncc(-c2ccc(C(=O)/N=c3\[nH]c4cc(N(C)C(=O)c5ccccc5)ccc4n3CC(C)(C)O)s2)o1 CHEMBL492931 IC50 3.0 nM
CN(C)Cc1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3cn[nH]c3)s1)n2CC(C)(C)O CHEMBL494136 IC50 3.0 nM
CC(C)(O)Cn1/c(=N/C(=O)c2ccc(-c3cn[nH]c3)s2)[nH]c2cc(CN3CCCCC3)ccc21 CHEMBL493007 IC50 3.0 nM
CC(C)(O)Cn1/c(=N/C(=O)c2ccc(-c3cn[nH]c3)s2)[nH]c2cc(CN3CCCCC3CO)ccc21 CHEMBL493008 IC50 3.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCC(N)=O CHEMBL460824 IC50 3.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)nc(NC(=O)c1ccccc1)n2CCC(N)=O CHEMBL485202 IC50 3.0 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1ccc(Br)cc1)n2CCC(N)=O CHEMBL485607 IC50 3.0 nM
CC(C(=O)C1CCCCC1)c1ccc2c(c1)nc(CC(=O)c1ccc(C#N)cc1)n2CCC(N)=O CHEMBL485591 IC50 3.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3ccnc(F)c3)s1)n2CCC(N)=O CHEMBL520110 IC50 3.0 nM
CC12Cc3[nH]nc(C(=O)Nc4cnn(Cc5ccccc5)c4)c3CC1C2 CHEMBL3298369 Ki 3.0 nM
CN(C(=O)C(F)(F)C1CCOCC1)c1ccc2[nH]c(-c3n[nH]c4c3C[C@@H]3C[C@]3(C)C4)nc2c1 CHEMBL5088468 IC50 3.0 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 3.162 nM
C=CC(=O)N1CCC[C@@H]1Cn1/c(=N/C(=O)c2ccc(C(F)F)s2)[nH]c2cc(CN[C@@H](C)C(C)(C)C)ccc21 CHEMBL4541397 IC50 3.2 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(C(F)F)s3)nc3cc(CN[C@@H](C)C(C)(C)C)ccc31)C2 CHEMBL4206487 IC50 3.23 nM
O=C(Nc1ccn(Cc2ccccc2)n1)c1n[nH]c2ccccc12 CHEMBL3263038 Ki 3.4 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 3.59 nM
C=CC(=O)N1CCC(Oc2nc(Nc3ccc(N4CCOCC4)cc3)nc3[nH]cc(-c4cncc(NC)c4)c23)CC1 CHEMBL4440621 IC50 3.6 nM
C=CC(=O)NCCOc1cc(C(O)c2ccccc2)cc2[nH]c(-c3n[nH]c4cc(C(F)F)ccc34)cc12 CHEMBL4637414 IC50 3.6 nM
C=CC(=O)N1CCC[C@@H](Oc2nc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)nc3[nH]cc(-c4cncc(NC)n4)c23)C1 CHEMBL4469900 IC50 3.7 nM
C=CC(=O)N1CCC(Oc2nc(Nc3ccc(N4CCOCC4)cc3)nc3[nH]cc(-c4cncc(NC)n4)c23)CC1 CHEMBL4443805 IC50 3.7 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 3.981 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 3.981 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)O)c5)cnc(N)c34)cc2)c1 CHEMBL1989708 pKi 3.981 nM
COc1ccc2nc(Nc3cc(Cc4ccccc4)nc(N[C@H]4CC[C@H](O)CC4)n3)sc2c1 CHEMBL2441112 pKi 3.981 nM
CC(C)(O)Cn1/c(=N/C(=O)c2ccc(-c3cn[nH]c3)s2)[nH]c2cc(CN)ccc21 CHEMBL499219 IC50 4.0 nM
CN(C(=O)c1cccnc1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCC(N)=O CHEMBL485030 IC50 4.0 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCC(N)=O CHEMBL485556 IC50 4.0 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1ccc(Cl)cc1)n2CCC(N)=O CHEMBL483403 IC50 4.0 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1cccc(C#N)c1)n2CCC(N)=O CHEMBL485555 IC50 4.0 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCCn1ccnc1 CHEMBL485031 IC50 4.0 nM
Cc1cc(Nc2cc(S(=O)(=O)c3ccccc3)cc(N[C@H]3CC[C@H](O)CC3)n2)n[nH]1 CHEMBL3355726 Ki 4.0 nM
CC[C@@H](C(=O)N(C)c1ccc2cc(-c3n[nH]c4c3CCC(C)(C)C4)[nH]c2c1)N1CCOCC1 CHEMBL4636432 IC50 4.0 nM
C=CC(=O)NCCOc1cc(Cc2ccccc2)cc2[nH]c(-c3n[nH]c4cc(C(F)F)ccc34)cc12 CHEMBL4646281 IC50 4.0 nM
CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL4116008 IC50 4.0 nM
CNc1cc(-c2c[nH]c3nc(Nc4ccc(N5CCOCC5)cc4)nc(Oc4ccccc4)c23)ccn1 CHEMBL4471602 IC50 4.8 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(/C=C/C#N)s1)n2CCC(N)=O CHEMBL519250 IC50 5.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(/C=C/c3cccnc3)s1)n2CCC(N)=O CHEMBL485922 IC50 5.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(/C=C/c3ncc(N)cn3)s1)n2CCC(N)=O CHEMBL500517 IC50 5.0 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1cccnc1)n2CCC(N)=O CHEMBL485232 IC50 5.0 nM
CN1CCN(CCCn2c(NC(=O)c3ccc(C#N)cc3)nc3cc(N(C)C(=O)C4CCCCC4)ccc32)CC1 CHEMBL523633 IC50 5.0 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCC(=O)N1CCNCC1 CHEMBL491076 IC50 5.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3cccnc3)s1)n2CCC(N)=O CHEMBL481378 IC50 5.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3ccc(F)nc3)s1)n2CCC(N)=O CHEMBL475593 IC50 5.0 nM
C=CC(=O)N1CC[C@H](Nc2cc(CN[C@@H](C)C(C)(C)C)cc(Nc3nc4cccnc4s3)n2)C1 CHEMBL3397909 IC50 5.0 nM
O=C(Nc1cccc([C@@H]2CN(c3ncnc4[nH]ccc34)CCN2CCO)c1)Nc1c(F)cccc1N1CCCC1 CHEMBL4564973 Kd 5.0 nM
C=CC(=O)NCCOc1cc(Cc2ccc(OC)cc2)cc2[nH]c(-c3n[nH]c4cc(C(F)F)ccc34)cc12 CHEMBL4645126 IC50 5.0 nM
Cc1cc2[nH]c(-c3n[nH]c4c3C[C@@H]3C[C@]3(C)C4)nc2cc1N(C)C(=O)CN1CCOCC1=O CHEMBL5086824 IC50 5.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 pKi 5.012 nM
CCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)csc12 CHEMBL1979516 pKi 5.012 nM
CNc1cncc(-c2c[nH]c3nc(Nc4ccc(N5CCN(C(C)=O)CC5)cc4)nc(OC4CCCCC4)c23)n1 CHEMBL4520286 IC50 5.1 nM
COc1ccc([C@H]2C[C@@H]2C(=O)Nc2nc3ccc(-c4cncc(CO)c4)cc3s2)cc1 CHEMBL3086327 Ki 5.3 nM
COc1cccc(-c2cc(Nc3cc(S(=O)(=O)c4ccccc4)cc(N[C@H]4CC[C@H](O)CC4)n3)n[nH]2)c1 CHEMBL3355731 Ki 5.3 nM
CC1(C)CCc2c(C(=O)Nc3cnn(Cc4ccccc4)c3)n[nH]c2C1 CHEMBL3298288 Ki 5.3 nM
CNc1cncc(-c2c[nH]c3nc(Nc4ccc(N5CCN(C(C)=O)CC5)cc4)nc(Oc4ccccc4)c23)n1 CHEMBL4465231 IC50 5.4 nM
C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)nc3[nH]cc(-c4cncc(NC)n4)c23)c1 CHEMBL4438914 IC50 5.4 nM
C=CC(=O)NCCOc1cccc2[nH]c(-c3n[nH]c4cc(C(F)F)ccc34)cc12 CHEMBL4640099 IC50 5.6 nM
C=CC(=O)N1CCC[C@@H](Oc2nc(Nc3ccc(N4CCOCC4)cc3)nc3[nH]cc(-c4cncc(NC)n4)c23)C1 CHEMBL4458344 Ki 5.8 nM
C=CC(=O)NCCOc1cc(Cc2ccccc2)cc2[nH]c(-c3n[nH]c4cc(-c5cn[nH]c5)ccc34)cc12 CHEMBL4639739 IC50 5.8 nM
COc1cc(C)c(Sc2cnc(Nc3cc(C)cc(C)n3)s2)cc1C(=O)N1CCN(C(C)=O)CC1 CHEMBL208846 IC50 6.0 nM
COCCCn1c(NC(=O)c2cccnc2)nc2cc(CN(C)C3CCCCC3)ccc21 CHEMBL487357 IC50 6.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(/C=C/c3ccccn3)s1)n2CCC(N)=O CHEMBL486951 IC50 6.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(/C=C/c3ccccc3N)s1)n2CCC(N)=O CHEMBL507769 IC50 6.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(/C=C/c3ccc(N)cc3)s1)n2CCC(N)=O CHEMBL500349 IC50 6.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)nc(NC(=O)c1ccc(Cl)cc1)n2CCC(N)=O CHEMBL485203 IC50 6.0 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCc1ccccc1 CHEMBL519347 IC50 6.0 nM
Cc1ncc(-c2ccc(C(=O)/N=c3\[nH]c4cc(N(C)C(=O)c5ccccc5)ccc4n3CCC(N)=O)s2)o1 CHEMBL480754 IC50 6.0 nM
Cc1cc2[nH]c(-c3n[nH]c4c3C[C@@H]3C[C@]3(C)C4)nc2cc1N(C)C(=O)[C@H](C)N1CCOCC1 CHEMBL5084598 IC50 6.0 nM
Cc1c(N(C)C(=O)[C@H](C)N2CCOCC2)cc2nc(-c3n[nH]c4c3C[C@@H]3C[C@]3(C)C4)[nH]c2c1F CHEMBL5074957 IC50 6.0 nM
C=CC(=O)NCCOc1cccc2[nH]c(-c3n[nH]c4cc(-c5cn[nH]c5)ccc34)cc12 CHEMBL4640397 IC50 6.1 nM
CC1(C)CCc2c(C(=O)Nc3cnn([C@@H](CCS(C)(=O)=O)c4ccccc4)c3)n[nH]c2C1 CHEMBL3298374 Ki 6.2 nM
C=CC(=O)NCCOc1cc(C(OC2CCOCC2)c2ccccc2)cc2[nH]c(-c3n[nH]c4cc(C(F)F)ccc34)cc12 CHEMBL4633295 IC50 6.2 nM
O[C@H]1CC[C@H](Nc2nc(Nc3cc4ccccc4cn3)cc(C(F)(F)c3ccc(F)cc3)n2)CC1 CHEMBL2441281 pKi 6.31 nM
CS(=O)(=O)N1CCOC(CNc2nc(Cc3ccccc3)cc(Nc3cc(-c4ccco4)[nH]n3)n2)C1 CHEMBL2441279 pKi 6.31 nM
COc1ccc(C2CC2C(=O)Nc2nc3ccc(-c4cn[nH]c4)cc3s2)cc1 CHEMBL3086329 Ki 6.4 nM
COc1ccc([C@H]2C[C@@H]2C(=O)Nc2nc3ccc(-c4cc[nH]c(=O)c4)cc3s2)cc1 CHEMBL3086328 Ki 6.6 nM
O=C(Nc1cnn([C@H](CO)c2ccccc2)c1)c1n[nH]c2cc(-c3cn[nH]c3)ccc12 CHEMBL3263051 Ki 6.6 nM
CNCc1ccc(C(=O)Nc2ncc(Sc3cc(C(=O)N4CCOCC4)c(OC)cc3C)s2)[nH]1 CHEMBL209881 IC50 7.0 nM
CC(=O)N1CCN(C(=O)c2cc(Sc3cnc(Nc4cc(C)cc(C)n4)s3)ccc2O)CC1 CHEMBL379478 IC50 7.0 nM
CC(=O)N1CCN(C(=O)c2cc(Sc3cnc(Nc4cccc(Br)n4)s3)ccc2O)CC1 CHEMBL210248 IC50 7.0 nM
C=Cc1ccc(C(=O)/N=c2\[nH]c3cc(N(C)C(=O)c4ccccc4)ccc3n2CCC(N)=O)s1 CHEMBL487785 IC50 7.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(/C=C/c3cccc(N)n3)s1)n2CCC(N)=O CHEMBL501661 IC50 7.0 nM
COc1ccc(C(=O)N(C)c2ccc3c(c2)nc(NC(=O)c2ccc(C#N)cc2)n3CCC(N)=O)cc1 CHEMBL485626 IC50 7.0 nM
CCN(C(=O)c1ccccc1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCC(N)=O CHEMBL462301 IC50 7.0 nM
CCN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCC(N)=O CHEMBL458787 IC50 7.0 nM
CNc1cc(-c2c[nH]c(=O)c(NC(=O)c3ccc(N4CCCCC4)cc3)c2)ccn1 CHEMBL1765774 Ki 7.0 nM
CNc1cncc(-c2c[nH]c(=O)c(NC(=O)c3ccc(N4CCC[C@H]4CN4CCCC4)cc3)c2)n1 CHEMBL1765781 Ki 7.0 nM
CCC(O)(CC)c1ccc2c(-c3ccc(OC)cc3)c(-c3n[nH]c4ccsc34)[nH]c2c1 CHEMBL2017555 IC50 7.0 nM
CNc1cncc(-c2c[nH]c3nc(Nc4ccc(N5CCN(C(C)=O)CC5)cc4)nc(OC4CCOCC4)c23)n1 CHEMBL4562744 IC50 7.1 nM
N#Cc1cccc(Cn2cc(NC(=O)c3n[nH]c4cc(-c5cc[nH]n5)ccc34)cn2)c1 CHEMBL3263037 Ki 7.8 nM
C=CC(=O)N1CCC[C@H]1COc1nc(Nc2ccc(N3CCN(C(C)=O)CC3)cc2)nc2[nH]cc(-c3cncc(NC)n3)c12 CHEMBL4543893 IC50 7.8 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 7.943 nM
Cc1ncc(-c2ccc(C(=O)/N=c3\[nH]c4cc(CN(C)C5CCCCC5)ccc4n3CC(C)(C)O)s2)o1 CHEMBL493106 IC50 8.0 nM
Cc1ncc(-c2ccc(C(=O)/N=c3\[nH]c4cc(CNC5CCCCC5)ccc4n3CC(C)(C)O)s2)o1 CHEMBL493107 IC50 8.0 nM
CN(Cc1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3cn[nH]c3)s1)n2CC(C)(C)O)c1ccccc1 CHEMBL493318 IC50 8.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(/C=C/c3cnccn3)s1)n2CCC(N)=O CHEMBL488596 IC50 8.0 nM
CN(C(=O)C1CCC(F)(F)CC1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCC(N)=O CHEMBL519033 IC50 8.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)s1)n2CCC(N)=O CHEMBL457706 IC50 8.0 nM
CN(C(=O)C1CCC1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCC(N)=O CHEMBL516958 IC50 8.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3ncco3)s1)n2CCC(N)=O CHEMBL482367 IC50 8.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3ccnc(C#N)c3)s1)n2CCC(N)=O CHEMBL481738 IC50 8.0 nM
O=S(=O)(c1ccccc1)c1cc(Nc2nc3ccccc3s2)nc(N[C@H]2CC[C@H](O)CC2)c1 CHEMBL3355729 Ki 8.0 nM
CC1(CO)CCc2c(C(=O)Nc3cnn(Cc4ccccc4)c3)n[nH]c2C1 CHEMBL3298293 Ki 8.0 nM
C[C@@H](C(=O)N(C)c1cc(O)c2[nH]c(-c3n[nH]c4c3C[C@@H]3C[C@]3(C)C4)nc2c1)N1CCOCC1 CHEMBL5079033 IC50 8.0 nM
N#Cc1cccc(Cn2cc(NC(=O)c3n[nH]c4c3CC(c3cn[nH]c3)CC4)cn2)c1 CHEMBL3298286 Ki 8.3 nM
C=CS(=O)(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)c1C CHEMBL4248386 IC50 8.3 nM
CN(C)Cc1ccc([C@H]2C[C@@H]2C(=O)Nc2nc3ccc(-c4cccnc4)cc3s2)cc1 CHEMBL3086534 Ki 8.4 nM
C#CCCOC(c1ccccc1)c1cc(OCCNC(=O)C=C)c2cc(-c3n[nH]c4cc(C(F)F)ccc34)[nH]c2c1 CHEMBL4638717 IC50 8.5 nM
CCC(O)(CC)c1ccc2cc(-c3n[nH]c4cc(-c5ccccc5)sc34)[nH]c2c1 CHEMBL2017557 IC50 8.6 nM
C=CC(=O)N1CCC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL3647964 IC50 8.9 nM
COc1cc(C)c(Sc2cnc(NC(=O)C3CC3)s2)cc1C(=O)N1CCN(C(C)=O)CC1 CHEMBL211842 IC50 9.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(/C=C/c3cccc(N)c3)s1)n2CCC(N)=O CHEMBL499247 IC50 9.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(/C=C/c3ccc(O)cc3)s1)n2CCC(N)=O CHEMBL280766 IC50 9.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(/C=C/c3cn[nH]c3)s1)n2CCC(N)=O CHEMBL485936 IC50 9.0 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1cccc(Br)c1)n2CCC(N)=O CHEMBL483397 IC50 9.0 nM
CNC(=O)CCn1c(NC(=O)c2ccc(C#N)cc2)nc2cc(N(C)C(=O)C3CCCCC3)ccc21 CHEMBL483763 IC50 9.0 nM
O=C(CCl)NCCOc1cccc2[nH]c(-c3n[nH]c4cc(C(F)F)ccc34)cc12 CHEMBL4638552 IC50 9.0 nM
C=CC(=O)NCCOc1cc(Cc2cccc(OC)c2)cc2[nH]c(-c3n[nH]c4cc(C(F)F)ccc34)cc12 CHEMBL4635070 IC50 9.0 nM
CCc1cc2[nH]c(-c3n[nH]c4c3C[C@@H]3C[C@]3(C)C4)nc2cc1N(C)C(=O)[C@H](C)N1CCOCC1 CHEMBL5082562 IC50 9.0 nM
COC(=O)/C=C/c1ccc(C(=O)/N=c2\[nH]c3cc(N(C)C(=O)c4ccccc4)ccc3n2CCC(N)=O)s1 CHEMBL487786 IC50 10.0 nM
Cc1ccc(C(=O)N(C)c2ccc3c(c2)nc(NC(=O)c2ccc(C#N)cc2)n3CCC(N)=O)cc1 CHEMBL484945 IC50 10.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)nc(NC(=O)c1ccno1)n2CCC(N)=O CHEMBL458796 IC50 10.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)nc(NC(=O)c1ccoc1)n2CCC(N)=O CHEMBL460389 IC50 10.0 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1ccno1)n2CCC(N)=O CHEMBL485565 IC50 10.0 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1ccco1)n2CCC(N)=O CHEMBL485233 IC50 10.0 nM
COc1cccc(C(=O)Nc2nc3cc(N(C)C(=O)C4CCCCC4)ccc3n2CCC(N)=O)c1 CHEMBL520312 IC50 10.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3csc(N)n3)s1)n2CCC(N)=O CHEMBL520432 IC50 10.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3ccc(C#N)nc3)s1)n2CCC(N)=O CHEMBL521113 IC50 10.0 nM
Cc1ccc2cc(-c3n[nH]c4ccc(NC5CCN(C)CC5)cc34)[nH]c2c1 CHEMBL1684542 IC50 10.0 nM
C=CC(=O)N1CCCC(n2nc(-c3cccc(C(=O)Nc4cccc(C(C)(C)C)c4)c3)c3c(N)ncnc32)C1 CHEMBL2179790 IC50 10.0 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3cccc(C(=O)NCc4ccc(C(C)(C)C)cc4)c3)c3c(N)ncnc32)C1 CHEMBL2179806 IC50 10.0 nM
C#CC(=O)N1CCC[C@@H](n2nc(-c3cccc(C(=O)Nc4ccc(C(C)C)cc4)c3)c3c(N)ncnc32)C1 CHEMBL2179781 IC50 10.0 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3cccc(C(=O)Nc4ccc(C(C)C)cc4)c3)c3c(N)ncnc32)C1 CHEMBL2179804 IC50 10.0 nM
N#Cc1cccc(Cn2cc(NC(=O)c3n[nH]c4cc(-c5cccnc5)ccc34)cn2)c1 CHEMBL3262783 Ki 10.0 nM
O=C(Nc1cnn(Cc2ccccc2)c1)c1n[nH]c2c1CCC1(CC1)C2 CHEMBL3298291 Ki 10.0 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3cncs3)nc3cc(CN[C@@H](C)C(C)(C)C)ccc31)C2 CHEMBL4202618 IC50 10.1 nM
COc1cc(C)c(Sc2cnc(NC(=O)c3ccc(CNC(C)C(C)(C)C)cc3)s2)cc1C(=O)N1CCN(C(C)=O)CC1 CHEMBL209148 IC50 10.3 nM
CCC(O)(CC)c1cc(OCCN2CCOCC2)c2cc(-c3n[nH]c4ccsc34)[nH]c2c1 CHEMBL2017554 IC50 10.9 nM
Cc1ncc(-c2ccc(C(=O)/N=c3\[nH]c4cc(CNc5ccccc5)ccc4n3CC(C)(C)O)s2)o1 CHEMBL492758 IC50 11.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(/C=C/c3ccccc3)s1)n2CCC(N)=O CHEMBL519239 IC50 11.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3nccs3)s1)n2CCC(N)=O CHEMBL481559 IC50 11.0 nM
CNc1cncc(-c2c[nH]c(=O)c(NC(=O)c3ccc(N4CCCCC4)cc3)c2)n1 CHEMBL1765779 Ki 11.0 nM
CC[C@@H](c1ccccc1)n1cc(NC(=O)c2n[nH]c3ccccc23)cn1 CHEMBL3263044 Ki 11.0 nM
C=CC(=O)NC1(COc2cccc3[nH]c(-c4n[nH]c5cc(C(F)F)ccc45)cc23)CC1 CHEMBL4644905 IC50 11.0 nM
CC(=O)N1CCN(C(=O)c2cc(Sc3cnc(NC(=O)c4ccc(N(C)C)cc4)s3)c(C)cc2O)CC1 CHEMBL211355 IC50 12.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(/C=C/n3ccnc3)s1)n2CCC(N)=O CHEMBL487571 IC50 12.0 nM
CN(C(=O)c1ccc(Cl)cc1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCC(N)=O CHEMBL484766 IC50 12.0 nM
COc1ccc(C(=O)Nc2nc3cc(N(C)C(=O)C4CCCCC4)ccc3n2CCC(N)=O)cc1 CHEMBL484940 IC50 12.0 nM
CNc1cncc(-c2c[nH]c3nc(Nc4ccc(N5CCS(=O)(=O)CC5)cc4)nc(Oc4ccccc4)c23)n1 CHEMBL4590851 IC50 12.0 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 pKi 12.59 nM
O[C@H]1CC[C@H](Nc2nc(Cc3ccccc3)cc(Nc3nc4ccc(C(F)(F)F)cc4s3)n2)CC1 CHEMBL2441272 pKi 12.59 nM
COc1cccc(/C=C/c2ccc(C(=O)/N=c3\[nH]c4cc(N(C)C(=O)c5ccccc5)ccc4n3CCC(N)=O)s2)c1 CHEMBL454220 IC50 13.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3cnccn3)s1)n2CCC(N)=O CHEMBL519927 IC50 13.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 13.0 nM
COc1cc(C)c(Sc2cnc(NC(=O)c3ccc[nH]3)s2)cc1C(=O)N1CCN(C(C)=O)CC1 CHEMBL209163 IC50 14.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)nc(NC(=O)c1cccs1)n2CCC(N)=O CHEMBL457886 IC50 14.0 nM
CN(C)C(=O)CCn1c(NC(=O)c2ccc(C#N)cc2)nc2cc(N(C)C(=O)C3CCCCC3)ccc21 CHEMBL483764 IC50 14.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(Cl)s1)n2CCC(N)=O CHEMBL481379 IC50 14.0 nM
CC(=O)c1ccc(C(=O)/N=c2\[nH]c3cc(N(C)C(=O)c4ccccc4)ccc3n2CCC(N)=O)s1 CHEMBL480573 IC50 14.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3cocn3)s1)n2CCC(N)=O CHEMBL521432 IC50 14.0 nM
Cn1cnc(Nc2cc(S(=O)(=O)c3ccccc3)cc(N[C@H]3CC[C@H](O)CC3)n2)c1 CHEMBL3355727 Ki 14.0 nM
c1ccc(Oc2nc(Nc3ccc(N4CCOCC4)cc3)nc3[nH]cc(-c4ccncc4)c23)cc1 CHEMBL4546936 IC50 14.0 nM
Nc1cccc(Oc2nc(Nc3ccc(N4CCOCC4)cc3)nc3[nH]cc(-c4ccncc4)c23)c1 CHEMBL4559339 IC50 14.0 nM
O=C(O)C1CCN(C(=O)c2cc(Sc3cnc(Nc4cccc(Br)n4)s3)ccc2O)CC1 CHEMBL210123 IC50 15.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(Br)s1)n2CCC(N)=O CHEMBL481380 IC50 15.0 nM
N#Cc1cccc(Cn2cc(NC(=O)c3n[nH]c4ccccc34)cn2)c1 CHEMBL3262780 Ki 15.0 nM
CN(C)CC[C@H](c1ccccc1)n1cc(NC(=O)c2n[nH]c3c2CCC(C)(C)C3)cn1 CHEMBL3298372 Ki 15.0 nM
Cc1c(-c2c(F)cc(C(N)=O)c3[nH]c4c(c23)CC[C@H](C(C)(C)O)C4)cccc1-n1c(=O)c2cccc(F)c2n(C)c1=O CHEMBL3900554 IC50 15.0 nM
CNc1cncc(-c2c[nH]c3nc(Nc4ccc(N5CCN(C)CC5)cc4)nc(Oc4ccccc4)c23)n1 CHEMBL4540819 IC50 15.0 nM
C=CC(=O)N[C@@H]1Cn2c(c(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1=C CHEMBL4211949 IC50 15.1 nM
CNC(=O)C(C)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(C)cc5)cc4)csc23)cn1 CHEMBL1970142 pKi 15.85 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cnc4c(-c5cnn(C)c5)cnn4c3N)cc2)c1 CHEMBL508928 pKi 15.85 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1970317 pKi 15.85 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 15.85 nM
COc1ccc2nc(Nc3cc(C(F)(F)c4ccc(F)cc4)nc(N[C@H]4CC[C@H](O)CC4)n3)sc2n1 CHEMBL2441285 pKi 15.85 nM
NC(=O)C1CCN1c1nc(Cc2ccccc2)cc(Nc2cc(C3CCC3)[nH]n2)n1 CHEMBL2441278 pKi 15.85 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1ccccc1)n2CCC(N)=O CHEMBL519698 IC50 16.0 nM
CCCCn1c(NC(=O)c2ccc(C#N)cc2)nc2cc(N(C)C(=O)C3CCCCC3)ccc21 CHEMBL484390 IC50 16.0 nM
COCCCn1c(NC(=O)c2ccc(C#N)cc2)nc2cc(N(C)C(=O)C3CCCCC3)ccc21 CHEMBL484767 IC50 16.0 nM
Cc1ccc2cc(-c3n[nH]c4ccc(NC5CCNCC5)cc34)[nH]c2c1 CHEMBL1684541 IC50 16.0 nM
CNc1nccc(-c2c[nH]c(=O)c(NC(=O)c3ccc(N4CCCCC4)cc3)c2)n1 CHEMBL1738829 Ki 16.0 nM
Cc1cc2[nH]c(-c3n[nH]c4c3C[C@@H]3C[C@]3(C)C4)nc2cc1N(C)C(=O)[C@@H](C)N1CCOCC1 CHEMBL5080834 IC50 16.0 nM
COc1cc(C)c(Sc2cnc(NC(=O)c3ccc(N(C)C)cc3)s2)cc1C(=O)N1CCN(C(C)=O)CC1 CHEMBL379114 IC50 18.0 nM
CCCN(C(=O)c1ccccc1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCC(N)=O CHEMBL462514 IC50 18.0 nM
CN1CCN(C(=O)CCn2c(NC(=O)c3ccc(C#N)cc3)nc3cc(N(C)C(=O)C4CCCCC4)ccc32)CC1 CHEMBL444151 IC50 18.0 nM
COc1cc(C)c(Sc2cnc(NC(=O)C3CC3)s2)cc1C(=O)N1CCN(C(=O)CN(C)C)CC1 CHEMBL208901 IC50 19.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3ccccn3)s1)n2CCC(N)=O CHEMBL481721 IC50 19.0 nM
CC(C)(C)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1970104 pKi 19.95 nM
COc1ccc2nc(Nc3cc(C(F)(F)c4ccc(F)cc4)nc(N[C@H]4CC[C@H](O)CC4)n3)sc2c1 CHEMBL2441286 pKi 19.95 nM
COCc1ccc(C(=O)Nc2ncc(Sc3cc(C(=O)N4CCN(C(C)=O)CC4)c(OC)cc3C)s2)cc1 CHEMBL211291 IC50 20.0 nM
COCCCn1c(NC(=O)c2cccc(C#N)c2)nc2cc(CN(C)C3CCCCC3)ccc21 CHEMBL519088 IC50 20.0 nM
CC(C)C(=O)c1ccc(C(=O)/N=c2\[nH]c3cc(N(C)C(=O)c4ccccc4)ccc3n2CCC(N)=O)s1 CHEMBL480554 IC50 20.0 nM
CC(C)CN(C)C(=O)c1ccc2cc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1684679 IC50 20.0 nM
Cn1cncc1CNC(=O)c1ccc2cc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1684681 IC50 20.0 nM
CNc1cncc(-c2c[nH]c(=O)c(NC(=O)c3ccc(N4CCC[C@H]4CN4CCCC4)cc3)c2)c1 CHEMBL1765782 Ki 20.0 nM
CNc1cc(F)cc(-c2c[nH]c(=O)c(NC(=O)c3ccc(N4CCC[C@H]4CN4CCCC4)cc3)c2)c1 CHEMBL1765783 Ki 20.0 nM
C=CC(=O)N1CCCC(n2nc(-c3cccc(C(=O)Nc4ccc(C(C)C)cc4)c3)c3c(N)ncnc32)C1 CHEMBL2179788 IC50 20.0 nM
O=S(=O)(c1ccccc1)c1cc(Nc2cc(-c3ccc(C(F)(F)F)cc3)[nH]n2)nc(N[C@H]2CC[C@H](O)CC2)c1 CHEMBL3355734 Ki 20.0 nM
O=C(N[C@@H]1CCCN(c2ncnc3[nH]ccc23)C1)[C@H](Nc1cc(Cl)cc(Cl)c1)C1CC1 CHEMBL5175032 Kd 20.0 nM
O=C(N[C@@H]1CCCN(c2ncnc3[nH]ccc23)C1)[C@H](Nc1cc(F)cc(Cl)c1)C1CC1 CHEMBL5205957 Kd 20.0 nM
Cc1c(-c2c(Cl)cc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)cc2c(Cl)cccn2c1=O CHEMBL3928976 IC50 21.0 nM
C=CC(=O)Nc1cccc(-n2c(=O)c(C)nc3cnc(Nc4ccc(OCCOC)cc4)nc32)c1 CHEMBL5087785 IC50 21.9 nM
CC1CCc2c(C(=O)Nc3cnn(Cc4ccccc4)c3)n[nH]c2C1 CHEMBL3298287 Ki 22.0 nM
Fc1cnccc1-c1c[nH]c2nc(Nc3ccc(N4CCOCC4)cc3)nc(Oc3ccccc3)c12 CHEMBL4535060 IC50 22.0 nM
CCC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCOCC4)cc3)nc3[nH]cc(-c4ccncc4)c23)c1 CHEMBL4445095 IC50 22.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)nc1)n2CCC(N)=O CHEMBL457705 IC50 23.0 nM
Cc1ccc2cc(-c3n[nH]c4ccc(NC5CCN(Cc6ccccc6)CC5)cc34)[nH]c2c1 CHEMBL1684543 IC50 23.0 nM
CNc1cncc(-c2c[nH]c(=O)c(NC(=O)c3ccc(N4CCCCC4)cc3)c2)c1 CHEMBL1765780 Ki 23.0 nM
C=CC(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]c4c(c23)CCC(C(C)(C)O)C4)c1C CHEMBL4241958 IC50 23.0 nM
CNc1cncc(-c2c[nH]c3nc(Nc4ccc(N5CCOCC5)cc4)nc(Oc4ccccc4)c23)n1 CHEMBL4475416 IC50 23.0 nM
C=CC(=O)NCCOc1cccc2[nH]c(-c3n[nH]c4cc(C)ccc34)cc12 CHEMBL4632386 IC50 23.0 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1cccs1)n2CCCN CHEMBL233338 IC50 25.0 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1ccncc1)n2CCC(N)=O CHEMBL485402 IC50 25.0 nM
C=CC(=O)NCCOc1cc(C(O)(c2ccccc2)c2ccccc2)cc2[nH]c(-c3n[nH]c4cc(C(F)F)ccc34)cc12 CHEMBL4639930 IC50 25.0 nM
C=CC(=O)NCCOc1cc(Cc2c(OC)cccc2OC)cc2[nH]c(-c3n[nH]c4cc(C(F)F)ccc34)cc12 CHEMBL4634889 IC50 25.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)c1 CHEMBL1967116 pKi 25.12 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 25.12 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc32)c1C CHEMBL1990885 pKi 25.12 nM
Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCC#N)c4c21)CNC3=O CHEMBL302449 pKi 25.12 nM
CN1CCN(C2CCC(n3cc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1 CHEMBL1997617 pKi 25.12 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(Br)cc1)n2CCC(N)=O CHEMBL481361 IC50 26.0 nM
Cc1ccc2cc(-c3n[nH]c4ccc(NS(=O)(=O)c5cn(C)cn5)cc34)[nH]c2c1 CHEMBL1684524 IC50 26.0 nM
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 CHEMBL4569508 IC50 26.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 26.0 nM
C=CC(=O)N1C[C@H](Nc2ncnc3[nH]ccc23)CC[C@@H]1C CHEMBL4085457 Ki 26.9 nM
CN(Cc1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCCO)C1CCCCC1 CHEMBL486334 IC50 27.0 nM
CCN(C(=O)c1ccccc1)c1ccc2c(c1)nc(NC(=O)c1ccno1)n2CCC(N)=O CHEMBL517901 IC50 27.0 nM
CN(C(=O)c1ccncc1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCC(N)=O CHEMBL485201 IC50 27.0 nM
Cc1ccc2cc(-c3n[nH]c4ccc(NC(C)CN(C)C)cc34)[nH]c2c1 CHEMBL1684656 IC50 27.0 nM
CNc1cc(C#N)cc(-c2c[nH]c(=O)c(NC(=O)c3ccc(N4CCC[C@H]4CN4CCCC4)cc3)c2)c1 CHEMBL1765784 Ki 27.0 nM
N#Cc1ccc(Cn2cc(NC(=O)c3n[nH]c4ccccc34)cn2)cc1 CHEMBL3263046 Ki 27.0 nM
CCNCc1ccc(C(=O)Nc2ncc(Sc3cc(C(=O)N4CCN(C(C)=O)CC4)c(OC)cc3C)s2)cc1 CHEMBL210985 IC50 29.0 nM
CC(=O)N1CCN(C(=O)c2cc(Sc3cnc(Nc4ccccn4)s3)ccc2O)CC1 CHEMBL208542 IC50 30.0 nM
CC(=O)N1CCN(C(=O)c2cc(Sc3cnc(NC(=O)c4ccc(N(C)C)cc4)s3)ccc2O)CC1 CHEMBL209004 IC50 30.0 nM
CN(Cc1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCCn1ccnc1)C1CCCCC1 CHEMBL487563 IC50 30.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(/C=C/c3cccc(C(F)(F)F)c3)s1)n2CCC(N)=O CHEMBL442826 IC50 30.0 nM
Cc1ccc2cc(-c3n[nH]c4ccc(NC5CCN(Cc6ccccc6)C5)cc34)[nH]c2c1 CHEMBL1684655 IC50 30.0 nM
COc1ccc([C@H]2C[C@@H]2C(=O)Nc2nc3ccc(-c4cn[nH]c4C)cc3s2)cc1 CHEMBL3086331 Ki 30.0 nM
C=CC(=O)Nc1cccc(-c2cnc3[nH]cc(-c4cc5ccccc5[nH]4)c3n2)c1 CHEMBL3984768 IC50 30.0 nM
C=CC(=O)Nc1cccc(-c2cnc3[nH]cc(Cl)c3c2)c1 CHEMBL3963521 IC50 30.0 nM
C=CC(=O)Nc1cccc(-c2cnc3[nH]cc(C)c3c2)c1 CHEMBL3902509 IC50 30.0 nM
C#CC1(C(=O)Nc2cccc(-c3cnc4[nH]cc(Cl)c4c3)c2)CC1 CHEMBL3901385 IC50 30.0 nM
CC#CC(=O)Nc1cccc(-c2cnc3[nH]cc(Cl)c3c2)c1 CHEMBL3919260 IC50 30.0 nM
C#CC(=O)Nc1cccc(-c2cnc3[nH]cc(Cl)c3c2)c1 CHEMBL3915825 IC50 30.0 nM
CCC#CC(=O)Nc1cccc(-c2cnc3[nH]cc(Cl)c3c2)c1 CHEMBL3926317 IC50 30.0 nM
O=C(CF)Nc1cccc(-c2cnc3[nH]cc(Cl)c3c2)c1 CHEMBL3953949 IC50 30.0 nM
CC#CC(=O)Nc1cccc(-c2cnc3[nH]cc(C)c3c2)c1 CHEMBL3938761 IC50 30.0 nM
CCC#CC(=O)Nc1cccc(-c2cnc3[nH]cc(C)c3c2)c1 CHEMBL3962690 IC50 30.0 nM
Cc1c[nH]c2ncc(-c3cccc(NC(=O)CF)c3)cc12 CHEMBL3911910 IC50 30.0 nM
C=CC(=O)Nc1cccc(-c2cnc3[nH]cc(-c4cccc(F)c4OC)c3c2)c1 CHEMBL3939895 IC50 30.0 nM
C=CC(=O)Nc1cccc(-c2cnc3[nH]cc(-c4cccc(S(=O)(=O)N(C)C(C)(C)C)c4)c3c2)c1 CHEMBL3917327 IC50 30.0 nM
C=CC(=O)Nc1cccc(-c2cnc3[nH]cc(-c4cccc(S(=O)(=O)N(CC)CC)c4)c3c2)c1 CHEMBL3948653 IC50 30.0 nM
C=CC(=O)Nc1cccc(-c2cnc3[nH]cc(-c4cccc(C(=O)OCC)c4)c3c2)c1 CHEMBL3918545 IC50 30.0 nM
C=CC(=O)Nc1cccc(-c2cnc3[nH]cc(-c4cc(F)cc(F)c4OC)c3c2)c1 CHEMBL3946420 IC50 30.0 nM
CCC#CC(=O)Nc1cc(-c2cnc3[nH]cc(C)c3c2)ccc1F CHEMBL3909234 IC50 30.0 nM
CCC#CC(=O)Nc1cccc(-c2cnc3[nH]cc(-c4cccc(S(=O)(=O)N(C)C(C)(C)C)c4)c3c2)c1 CHEMBL3979472 IC50 30.0 nM
C=CC(=O)Nc1cccc(-c2cnc3[nH]cc(-c4cccc(S(=O)(=O)N(C)C(C)(C)C)c4)c3n2)c1 CHEMBL3918168 IC50 30.0 nM
Cc1n[nH]c2ncc(-c3cccc(NC(=O)/C=C/N(C)C)c3)cc12 CHEMBL3979809 IC50 30.0 nM
Cc1n[nH]c2ncc(-c3ccc(Cl)c(NC(=O)/C=C/N(C)C)c3)cc12 CHEMBL3942125 IC50 30.0 nM
C=CC(=O)Nc1cc(-c2cnc3[nH]nc(C)c3c2)ccc1Cl CHEMBL3968188 IC50 30.0 nM
CC/C=C/C(=O)Nc1cccc(-c2cnc3[nH]nc(C)c3c2)c1 CHEMBL3967741 IC50 30.0 nM
C=CC(=O)Nc1cccc(-c2cnc3[nH]ccc3c2)n1 CHEMBL3976245 IC50 30.0 nM
C=CC(=O)Nc1cccc(-c2cnc3[nH]cc(Cl)c3c2)n1 CHEMBL3964955 IC50 30.0 nM
C=CC(=O)Nc1cc(-c2cnc3[nH]ccc3c2)ccc1F CHEMBL3904442 IC50 30.0 nM
C=CC(=O)Nc1cc(-c2cnc3[nH]cc(Cl)c3c2)ccc1F CHEMBL3907847 IC50 30.0 nM
C=CC(=O)Nc1cccc(-c2cnc3[nH]cc(-c4cc5ccccc5[nH]4)c3c2)c1 CHEMBL3958574 IC50 30.0 nM
C=CC(=O)Nc1cccc(-c2cnc3[nH]cc(-c4cc5ccc(C)cc5[nH]4)c3c2)c1 CHEMBL3914851 IC50 30.0 nM
C#CC(=O)Nc1cccc(-c2cnc3[nH]ccc3c2)n1 CHEMBL3920364 IC50 30.0 nM
CCC#CC(=O)Nc1cccc(-c2cnc3[nH]ccc3c2)n1 CHEMBL3951591 IC50 30.0 nM
C#CC(=O)Nc1cccc(-c2cnc3[nH]cc(Cl)c3c2)n1 CHEMBL3937076 IC50 30.0 nM
CCC#CC(=O)Nc1cccc(-c2cnc3[nH]cc(Cl)c3c2)n1 CHEMBL3966831 IC50 30.0 nM
CC#CC(=O)Nc1cccc(-c2cnc3[nH]ccc3c2)n1 CHEMBL3968455 IC50 30.0 nM
CC#CC(=O)Nc1cccc(-c2cnc3[nH]cc(Cl)c3c2)n1 CHEMBL3962931 IC50 30.0 nM
C#CC(=O)Nc1cc(-c2cnc3[nH]ccc3c2)ccc1F CHEMBL3986267 IC50 30.0 nM
C#CC(=O)Nc1cc(-c2cnc3[nH]cc(Cl)c3c2)ccc1F CHEMBL3957567 IC50 30.0 nM
CCC#CC(=O)Nc1cc(-c2cnc3[nH]ccc3c2)ccc1F CHEMBL3981782 IC50 30.0 nM
CCC#CC(=O)Nc1cc(-c2cnc3[nH]cc(Cl)c3c2)ccc1F CHEMBL3956377 IC50 30.0 nM
CC#CC(=O)Nc1cc(-c2cnc3[nH]ccc3c2)ccc1F CHEMBL3973770 IC50 30.0 nM
CC#CC(=O)Nc1cc(-c2cnc3[nH]cc(Cl)c3c2)ccc1F CHEMBL3944305 IC50 30.0 nM
C#CC(=O)Nc1cccc(-c2cnc3[nH]cc(C)c3c2)n1 CHEMBL3958612 IC50 30.0 nM
CCC#CC(=O)Nc1cccc(-c2cnc3[nH]cc(C)c3c2)n1 CHEMBL3927614 IC50 30.0 nM
CC#CC(=O)Nc1cccc(-c2cnc3[nH]cc(C)c3c2)n1 CHEMBL3967872 IC50 30.0 nM
C#CC(=O)Nc1cc(-c2cnc3[nH]cc(C)c3c2)ccc1F CHEMBL3893228 IC50 30.0 nM
O=C(N[C@@H]1CCCN(c2ncnc3[nH]ncc23)C1)[C@H](Nc1cc(Cl)cc(C(F)(F)F)c1)C1CC1 CHEMBL5179394 Kd 30.0 nM
CC(C)Oc1ccc2cccc(-n3cc(NC(N)=O)c(C(N)=O)n3)c2c1 CHEMBL5169921 IC50 30.0 nM
N#Cc1cccc(Cn2cc(NC(=O)c3n[nH]c4c3CCCC4)cn2)c1 CHEMBL3298285 Ki 31.0 nM
O=C(/C=C/C(F)(F)F)NCCOc1cccc2[nH]c(-c3n[nH]c4cc(C(F)F)ccc34)cc12 CHEMBL4638862 IC50 31.0 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)csc12 CHEMBL1982476 pKi 31.62 nM
CCN(CC)CCNC(=O)C=Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL2004716 pKi 31.62 nM
CNc1cncc(-c2c[nH]c3nc(Nc4ccc(N5CCOCC5)cc4)nc(Oc4ccccc4)c23)c1 CHEMBL4469956 IC50 32.0 nM
C=CC(=O)NCCOc1cc(Cc2ccccc2OC)cc2[nH]c(-c3n[nH]c4cc(C(F)F)ccc34)cc12 CHEMBL4644593 IC50 32.0 nM
O=C(O)C1CCCN(C(=O)c2cc(Sc3cnc(Nc4cccc(Br)n4)s3)ccc2O)C1 CHEMBL384680 IC50 34.0 nM
COc1ccc(Sc2cnc(NC(=O)c3ccc(N(C)C)cc3)s2)cc1C(=O)N1CCN(C(C)=O)CC1 CHEMBL210528 IC50 34.0 nM
COCCCn1c(NC(=O)c2ccc(C#N)cc2)nc2cc(CN(C)CC3CCCC3)ccc21 CHEMBL487983 IC50 34.0 nM
C=CC(=O)NCCOc1cc(Cc2cccc(C)c2)cc2[nH]c(-c3n[nH]c4cc(C(F)F)ccc34)cc12 CHEMBL4642453 IC50 34.0 nM
CC(=O)N1CCN(C(=O)c2cc(CSc3cnc(NC(=O)c4ccc(CNC(C)C(C)(C)C)[nH]4)s3)cc(C)c2C)CC1 CHEMBL381296 IC50 35.0 nM
CN(C(=O)c1ccc(OC(F)(F)F)cc1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCC(N)=O CHEMBL490269 IC50 35.0 nM
Cc1ccc(C(=O)Nc2nc3cc(N(C)C(=O)C4CCCCC4)ccc3n2CCC(N)=O)cc1 CHEMBL521468 IC50 35.0 nM
CC(C)n1c(NC(=O)c2ccc(C#N)cc2)nc2cc(N(C)C(=O)C3CCCCC3)ccc21 CHEMBL484395 IC50 35.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(OCc3ccccc3)s1)n2CCC(N)=O CHEMBL480574 IC50 35.0 nM
O=C(Nc1cnn(Cc2cccc(Cl)c2)c1)c1n[nH]c2ccccc12 CHEMBL3263047 Ki 35.0 nM
COCCCn1c(NC(=O)c2ccncc2)nc2cc(CN(C)C3CCCCC3)ccc21 CHEMBL488170 IC50 36.0 nM
Cc1ccc2cc(-c3n[nH]c4ccc(NS(C)(=O)=O)cc34)[nH]c2c1 CHEMBL1684516 IC50 36.0 nM
O=C(Nc1cnn(Cc2ccccc2)c1)c1n[nH]c2ccccc12 CHEMBL3263045 Ki 36.0 nM
C=C(C)c1ccc(C(=O)/N=c2\[nH]c3cc(N(C)C(=O)c4ccccc4)ccc3n2CCC(N)=O)s1 CHEMBL485937 IC50 37.0 nM
O=C(Nc1cnn(Cc2ccccc2)c1)c1n[nH]c2c1CC1CC1C2 CHEMBL3298368 Ki 37.0 nM
COC(=O)/C=C(\C)c1ccc(C(=O)/N=c2\[nH]c3cc(N(C)C(=O)c4ccccc4)ccc3n2CCC(N)=O)s1 CHEMBL486147 IC50 39.0 nM
C/C(=C\c1cccnc1)c1ccc(C(=O)/N=c2\[nH]c3cc(N(C)C(=O)c4ccccc4)ccc3n2CCC(N)=O)s1 CHEMBL504194 IC50 39.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(-c3ccccc3)s1)n2CCC(N)=O CHEMBL518937 IC50 39.0 nM
CN1CCN(C(=O)c2ccc3c(c2)[nH]c2c(C(N)=O)ccc(-c4ccccc4F)c23)CC1 CHEMBL3621496 IC50 39.0 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(OC(F)F)cc5)cc4)csc23)cn1 CHEMBL1988387 pKi 39.81 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cn[nH]c5)cnc(N)c34)cc2)c1 CHEMBL1969102 pKi 39.81 nM
Cc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1Nc1ccc(OCC(N)=O)cc1 CHEMBL1988838 pKi 39.81 nM
CC(=O)N1CCN(C(=O)c2cc(CSc3cnc(NC(=O)c4ccc(N5CCNCC5)cc4)s3)cc(C)c2C)CC1 CHEMBL207329 IC50 40.0 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1cccs1)n2CCC(N)=O CHEMBL485564 IC50 40.0 nM
C=CC(=O)NCCOc1cccc2[nH]c(-c3n[nH]c4cc(Br)ccc34)cc12 CHEMBL4637293 IC50 40.0 nM
O=C(N[C@@H]1CCCN(c2ncnc3[nH]ccc23)C1)[C@H](Nc1cc(Cl)cc(C(F)(F)F)c1)C1CC1 CHEMBL5182743 Kd 40.0 nM
CN(Cc1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCC(N)=O)C1CCCCC1 CHEMBL487358 IC50 41.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(/C=C/c3cccc([N+](=O)[O-])c3)s1)n2CCC(N)=O CHEMBL500583 IC50 42.0 nM
O=C(Nc1cnn(Cc2ccccc2)c1)c1n[nH]c2c1CCC1(CCOC1)C2 CHEMBL3298367 Ki 42.0 nM
CNc1cncc(-c2c[nH]c3nc(Nc4ccc(OCCOC)cc4)nc(Oc4ccccc4)c23)n1 CHEMBL4531769 IC50 42.0 nM
Cc1ccc2cc(-c3n[nH]c4ccc(NS(=O)(=O)c5ncn(C)c5C)cc34)[nH]c2c1 CHEMBL1684525 IC50 43.0 nM
COc1ccc([C@H]2C[C@@H]2C(=O)Nc2nc3ccc(-c4cnn(C)c4)cc3s2)cc1 CHEMBL3086330 Ki 43.0 nM
CN(C)Cc1cccc(Cn2cc(NC(=O)c3n[nH]c4ccccc34)cn2)c1 CHEMBL3263048 Ki 44.0 nM
COCCCn1c(NC(=O)c2ccc(C#N)cc2)nc2cc(CNC3CCCCC3)ccc21 CHEMBL487982 IC50 45.0 nM
Cc1ccc2cc(-c3n[nH]c4ccc(NS(=O)(=O)c5cccc(F)c5)cc34)[nH]c2c1 CHEMBL1684519 IC50 45.0 nM
COCCCn1c(NC(=O)c2ccc(C#N)cc2)nc2cc(CN(C)C3CCCCC3)ccc21 CHEMBL486757 IC50 46.0 nM
COCCCn1c(NC(=O)c2ccc(Cl)cc2)nc2cc(CN(C)C3CCCCC3)ccc21 CHEMBL488187 IC50 46.0 nM
CN(Cc1ccc2c(c1)nc(NC(=O)c1ccno1)n2CCCn1ccnc1)C1CCCCC1 CHEMBL488398 IC50 46.0 nM
CN(C(=O)C1CC1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCC(N)=O CHEMBL460823 IC50 46.0 nM
COc1cccc(S(=O)(=O)Nc2ccc3[nH]nc(-c4cc5ccc(C)cc5[nH]4)c3c2)c1 CHEMBL1684521 IC50 46.0 nM
CNc1cc(-c2c[nH]c(=O)c(NC(=O)c3ccc(N4CCCCC4)cc3)c2)ncn1 CHEMBL1765775 Ki 46.0 nM
C=CC(=O)Nc1cccc(-n2c(=O)c(C)nc3cnc(Nc4ccc(OC)cc4)nc32)c1 CHEMBL2437471 IC50 46.1 nM
COc1cc(C)c(Sc2cnc(NC(=O)c3ccc(OC(C)C)cc3)s2)cc1C(=O)N1CCN(C(C)=O)CC1 CHEMBL380058 IC50 47.0 nM
COCCCn1c(NC(=O)c2ccno2)nc2cc(CN(C)C3CCCCC3)ccc21 CHEMBL450635 IC50 47.0 nM
Cc1ccc2cc(-c3n[nH]c4ccc(NS(=O)(=O)c5ccccc5F)cc34)[nH]c2c1 CHEMBL1684518 IC50 47.0 nM
COCCCn1c(NC(=O)c2ccc(C#N)cc2)nc2cc(CNc3ccccc3)ccc21 CHEMBL518932 IC50 48.0 nM
O=C(Nc1nc2ccc(-c3ccncc3)cc2s1)[C@H]1C[C@@H]1c1ccccc1 CHEMBL3086544 Ki 50.0 nM
C=CC(=O)N1CCC([C@@H]2CCNC3C(C(N)=O)C(c4ccc(Oc5ccccc5)cc4)=NN32)CC1 CHEMBL5193128 IC50 50.0 nM
C=CC(=O)N1CCC([C@@H]2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)CC1 CHEMBL3936761 IC50 50.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 pKi 50.12 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)cc1 CHEMBL1982466 pKi 50.12 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)csc12 CHEMBL2005631 pKi 50.12 nM
Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1nc(Nc2ccc(C(=O)N3CCOCC3)cc2)c2nc[nH]c2n1 CHEMBL3263640 IC50 52.0 nM
COCCCn1c(NC(=O)c2ccno2)nc2cc(CNC3CCCCC3)ccc21 CHEMBL488399 IC50 53.0 nM
CC[C@H](c1ccccc1)n1cc(NC(=O)c2n[nH]c3ccccc23)cn1 CHEMBL3263043 Ki 53.0 nM
Cc1cc(Nc2cc(Cc3ccccc3)nc(N[C@H]3CC[C@H](O)CC3)n2)n[nH]1 CHEMBL3355311 Ki 53.0 nM
CCCN(C(=O)c1ccccc1)c1ccc2c(c1)nc(NC(=O)c1ccc(Cl)cc1)n2CCC(N)=O CHEMBL485584 IC50 54.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(C(=O)c3ccccc3)s1)n2CCC(N)=O CHEMBL480555 IC50 55.0 nM
CC(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]c4cc(C(=O)N5CCN(C)CC5)ccc4c23)c1C CHEMBL3621515 IC50 55.0 nM
C#CCCN1CCN(c2ccc(Nc3nc(OC4CCN(C(=O)C=C)CC4)c4c(-c5cncc(NC)n5)c[nH]c4n3)cc2)CC1 CHEMBL4562542 IC50 55.0 nM
Cc1cccc(C(=O)Nc2nc3cc(N(C)C(=O)C4CCCCC4)ccc3n2CCC(N)=O)c1 CHEMBL483602 IC50 56.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccsc1)n2CCC(N)=O CHEMBL521241 IC50 57.0 nM
COc1ccc(/C=C/c2ccc(C(=O)/N=c3\[nH]c4cc(N(C)C(=O)c5ccccc5)ccc4n3CCC(N)=O)s2)cc1 CHEMBL444394 IC50 58.0 nM
C=CC(=O)N1CC(Oc2cccc3[nH]c(-c4n[nH]c5cc(C(F)F)ccc45)cc23)C1 CHEMBL4643808 IC50 58.0 nM
C=CC(=O)NCCOc1cc(Cc2cccc(C(F)(F)F)c2)cc2[nH]c(-c3n[nH]c4cc(C(F)F)ccc34)cc12 CHEMBL4646367 IC50 58.0 nM
C/C(=C\c1ccncc1)c1ccc(C(=O)/N=c2\[nH]c3cc(N(C)C(=O)c4ccccc4)ccc3n2CCC(N)=O)s1 CHEMBL501963 IC50 59.0 nM
CC(=O)N(C)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCC(N)=O CHEMBL458797 IC50 59.0 nM
N#Cc1cccc(Cn2cc(NC(=O)c3n[nH]c4cc(-c5ccncc5)ccc34)cn2)c1 CHEMBL3262782 Ki 59.0 nM
CC(=O)N1CCN(C(=O)c2cc(Sc3cnc(NC(=O)c4ccc(N(C)C)cc4)s3)c(C)cc2C)CC1 CHEMBL206905 IC50 60.0 nM
CN(C(=O)c1ccc2c(c1)nc(NC(=O)c1cccs1)n2CCCCC(N)=O)C1CCCCC1 CHEMBL232769 IC50 60.0 nM
COc1ccc2cc(-c3n[nH]c4cccnc34)[nH]c2c1 CHEMBL1288582 IC50 60.0 nM
CN(Cc1ccccc1)C(=O)c1ccc2cc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1684676 IC50 60.0 nM
O=C(Cc1ccc2cc(-c3n[nH]c4cccnc34)[nH]c2c1)c1ccccc1 CHEMBL1684662 IC50 60.0 nM
CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 CHEMBL4281823 IC50 60.0 nM
Nc1nc(-c2cccc(-n3ccc4cc(C5CC5)cc(F)c4c3=O)c2CO)c2cc(C3=CCN(C4COC4)CC3)[nH]c2n1 CHEMBL5077961 IC50 60.9 nM
CN1CCN(CCn2c(NC(=O)c3ccc(C#N)cc3)nc3cc(N(C)C(=O)C4CCCCC4)ccc32)CC1 CHEMBL490872 IC50 61.0 nM
O=S(=O)(c1ccccc1)c1cc(Nc2cc(-c3ccc(OC(F)(F)F)cc3)[nH]n2)nc(N[C@H]2CC[C@H](O)CC2)c1 CHEMBL3355735 Ki 61.0 nM
CN(C(=O)c1ccc2c(c1)nc(NC(=O)c1cnco1)n2CCC(N)=O)C1CCCCC1 CHEMBL231747 IC50 62.0 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1 CHEMBL460472 IC50 62.0 nM
C=CC(=O)NCCOc1cc(Cc2c(C)cc(C)cc2C)cc2[nH]c(-c3n[nH]c4cc(C(F)F)ccc34)cc12 CHEMBL4640845 IC50 62.0 nM
C/C(=C\C#N)c1ccc(C(=O)/N=c2\[nH]c3cc(N(C)C(=O)c4ccccc4)ccc3n2CCC(N)=O)s1 CHEMBL519388 IC50 63.0 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL572878 pKi 63.1 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 63.1 nM
Nc1ncc(-c2ccncc2)c2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1970083 pKi 63.1 nM
O[C@H]1CC[C@H](Nc2nc(Nc3ncc(Cc4ccccc4)s3)cc(C(F)(F)c3ccc(F)cc3)n2)CC1 CHEMBL2441283 pKi 63.1 nM
C=CC(=O)NCCOc1cccc2[nH]c(-c3n[nH]c4ccccc34)cc12 CHEMBL4638993 IC50 64.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(/C=C/c3ccncc3)s1)n2CCC(N)=O CHEMBL488397 IC50 65.0 nM
Cc1ccc2cc(-c3n[nH]c4ccc(NC(=O)CN(C)C)cc34)[nH]c2c1 CHEMBL1684499 IC50 65.0 nM
C=CC(=O)NCCOc1cc(C(OCCS(C)(=O)=O)c2ccccc2)cc2[nH]c(-c3n[nH]c4cc(C(F)F)ccc34)cc12 CHEMBL4645223 IC50 65.0 nM
CCN1CCCC(Nc2ccc3[nH]nc(-c4cc5ccc(C)cc5[nH]4)c3c2)C1 CHEMBL1684653 IC50 66.0 nM
COc1ccccc1/C=C/c1ccc(C(=O)/N=c2\[nH]c3cc(N(C)C(=O)c4ccccc4)ccc3n2CCC(N)=O)s1 CHEMBL501364 IC50 67.0 nM
CC(=O)Nc1ccc2[nH]nc(-c3cc4ccc(C)cc4[nH]3)c2c1 CHEMBL1684497 IC50 67.0 nM
CC(=O)c1ccc(C(=O)Nc2nc3cc(N(C)C(=O)C4CCCCC4)ccc3n2CCC(N)=O)cc1 CHEMBL483181 IC50 68.0 nM
CN(C(=O)c1ccc2c(c1)nc(NC(=O)c1cccnc1)n2CCC(N)=O)C1CCCCC1 CHEMBL231958 IC50 69.0 nM
COCCCn1c(NC(=O)c2ccc(C#N)cc2)nc2cc(CN3CCOCC3)ccc21 CHEMBL488186 IC50 69.0 nM
Cc1ccc2cc(-c3n[nH]c4ccc(NS(=O)(=O)c5ccccc5)cc34)[nH]c2c1 CHEMBL1684517 IC50 69.0 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 69.0 nM
CC1(C)CCc2[nH]nc(C(=O)Nc3cnn(Cc4ccccc4)c3)c2C1 CHEMBL3298289 Ki 69.0 nM
Cc1ccc2cc(-c3n[nH]c4cc(C#N)ccc34)[nH]c2c1 CHEMBL1289729 IC50 70.0 nM
Cc1ccc2cc(-c3n[nH]c4cccnc34)[nH]c2c1 CHEMBL1288610 IC50 70.0 nM
CCN(CC)C(=O)c1ccc2cc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1684677 IC50 70.0 nM
COCCN(C)C(=O)c1ccc2cc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1684678 IC50 70.0 nM
COCCc1ccc2cc(-c3n[nH]c4cccnc34)[nH]c2c1 CHEMBL1684657 IC50 70.0 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3cccc(C(=O)NCc4ccc(C)cc4)c3)c3c(N)ncnc32)C1 CHEMBL2179786 IC50 70.0 nM
Cc1ccc2cc(-c3n[nH]c4ccc(NC(=O)Nc5c(C)noc5C)cc34)[nH]c2c1 CHEMBL1684531 IC50 72.0 nM
CC(C)Oc1cc(-n2cnc3ccc(N[C@@H](C)c4ccc(F)cn4)nc32)n[nH]1 CHEMBL2151321 IC50 72.2 nM
COc1c(F)cc(F)cc1-c1c[nH]c2ncc(-c3cc(NC(=O)/C=C/CN(C)C)ccc3F)cc12 CHEMBL3925725 IC50 72.4 nM
COc1cc(F)c(C)cc1-c1c[nH]c2ncc(-c3cccc(NC(=O)/C=C/CN(C)C)c3)cc12 CHEMBL3948029 IC50 72.4 nM
C=CC(=O)Nc1cccc(-c2cnc3[nH]cc(-c4cc(C)c(F)cc4OC)c3c2)c1 CHEMBL3920230 IC50 72.4 nM
Cc1cccc(-c2c[nH]c3ncc(-c4cccc(NC(=O)/C=C/CN(C)C)c4)cc23)c1F CHEMBL3943435 IC50 72.4 nM
C=CC(=O)Nc1cccc(-c2cnc3[nH]cc(-c4cccc(C)c4F)c3c2)c1 CHEMBL3919033 IC50 72.4 nM
C=CC(=O)Nc1cccc(-c2cnc3c(c2)CC(=O)N3)c1 CHEMBL3934456 IC50 72.4 nM
Cc1c[nH]c2ncc(-c3cccc(NC(=O)/C=C/CN(C)C)c3)cc12 CHEMBL3906494 IC50 72.4 nM
CN(C)C/C=C/C(=O)Nc1cccc(-c2cnc3[nH]cc(Cl)c3c2)c1 CHEMBL3921295 IC50 72.4 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CC(N)=O CHEMBL484934 IC50 73.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(N3CCOCC3)s1)n2CCC(N)=O CHEMBL480753 IC50 74.0 nM
C=CC(=O)N1CCC(Oc2nc(Nc3ccc(N4CCOCC4)cc3)nc3[nH]cc(-c4cccc(NC)n4)c23)CC1 CHEMBL4574694 IC50 74.0 nM
C/C(=C\c1ccccc1)c1ccc(C(=O)/N=c2\[nH]c3cc(N(C)C(=O)c4ccccc4)ccc3n2CCC(N)=O)s1 CHEMBL510587 IC50 75.0 nM
O=C(Nc1cnn(Cc2ccccc2)c1)c1n[nH]c2c1CCC1(COC1)C2 CHEMBL3298366 Ki 75.0 nM
CNc1cccc(-c2c[nH]c3nc(Nc4ccc(N5CCOCC5)cc4)nc(Oc4ccccc4)c23)c1 CHEMBL4566405 IC50 75.0 nM
CN(C(=O)c1ccc2c(c1)nc(NC(=O)c1ccc([N+](=O)[O-])cc1)n2CCC(N)=O)C1CCCCC1 CHEMBL392048 IC50 76.0 nM
CNc1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCC(N)=O CHEMBL461029 IC50 76.0 nM
Cc1ccc2cc(-c3n[nH]c4ccc(NC5CCCNC5)cc34)[nH]c2c1 CHEMBL1684545 IC50 77.0 nM
C=CC(=O)NCCOc1cc(Cc2cccc(Cl)c2)cc2[nH]c(-c3n[nH]c4cc(C(F)F)ccc34)cc12 CHEMBL4640218 IC50 78.0 nM
CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL1084546 pKi 79.43 nM
Cn1cc(-c2cnn3c(N)c(-c4ccc(NC(=O)Nc5cccc(C(F)(F)F)c5)cc4)cnc23)cn1 CHEMBL1988717 pKi 79.43 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 pKi 79.43 nM
N#Cc1ccc2[nH]nc(-c3cc4ccccc4[nH]3)c2c1 CHEMBL1288387 IC50 80.0 nM
N#Cc1ccc2c(-c3cc4ccccc4[nH]3)n[nH]c2c1 CHEMBL1288478 IC50 80.0 nM
COc1ccc2cc(-c3n[nH]c4cc(F)ccc34)[nH]c2c1 CHEMBL1289730 IC50 80.0 nM
Cc1ccc2cc(-c3n[nH]c4ccc(NC5CCNC5)cc34)[nH]c2c1 CHEMBL1684654 IC50 80.0 nM
CCN(C(=O)c1ccc2c(c1)nc(NC(=O)c1ccc(Br)cc1)n2CCC(N)=O)C1CCCCC1 CHEMBL232363 IC50 81.0 nM
COCCCn1c(NC(=O)c2ccc(C#N)cc2)nc2cc(CNCCOC)ccc21 CHEMBL487987 IC50 81.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(N3CCCC3)s1)n2CCC(N)=O CHEMBL481567 IC50 81.0 nM
O=C1[C@H](Nc2cc(F)cc(Cl)c2)CCCN1[C@@H]1CCCN(c2ncnc3[nH]ccc23)C1 CHEMBL5169765 Kd 82.0 nM
CS(=O)(=O)NC(=O)C1CCCN(C(=O)c2cc(Sc3cnc(Nc4cccc(Br)n4)s3)ccc2O)C1 CHEMBL211601 IC50 83.0 nM
CCNC(=O)Nc1ccc2[nH]nc(-c3cc4ccc(C)cc4[nH]3)c2c1 CHEMBL1684528 IC50 83.0 nM
C/C=C/C(=O)NCCOc1cccc2[nH]c(-c3n[nH]c4cc(C(F)F)ccc34)cc12 CHEMBL4637765 IC50 84.0 nM
Cc1ccc2cc(-c3n[nH]c4ccc(NS(=O)(=O)c5c(C)nn(C)c5C)cc34)[nH]c2c1 CHEMBL1684526 IC50 85.0 nM
O=C(Nc1nc2ccc(-c3cccnc3)cc2s1)[C@H]1C[C@@H]1c1ccccc1 CHEMBL3086545 Ki 85.0 nM
COc1ccc2cc(-c3n[nH]c4ccc(NC(C)=O)cc34)[nH]c2c1 CHEMBL1684508 IC50 87.0 nM
c1ccc(Oc2nc(Nc3ccc(N4CCOCC4)cc3)nc3[nH]cc(-c4cccnc4)c23)cc1 CHEMBL4458161 IC50 87.0 nM
C=CC(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)c1C CHEMBL4237557 IC50 88.0 nM
COc1ccc(CCn2c(NC(=O)c3ccc(C#N)cc3)nc3cc(N(C)C(=O)C4CCCCC4)ccc32)cc1 CHEMBL522085 IC50 89.0 nM
CC(=O)N1CCN(C(=O)c2cc(CSc3cnc(NC(=O)c4ccc(CNC(C)C(C)(C)C)cc4)s3)cc(C)c2C)CC1 CHEMBL382362 IC50 90.0 nM
CC(=O)N1CCN(C(=O)c2cc(Sc3cnc(NC(=O)c4ccc(N(C)C)cc4)s3)ccc2N)CC1 CHEMBL210243 IC50 90.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1cccc(-c3ccccc3)c1)n2CCC(N)=O CHEMBL520768 IC50 90.0 nM
Cc1ccc2cc(-c3n[nH]c4cc(C)ccc34)[nH]c2c1 CHEMBL1288480 IC50 90.0 nM
CC#CC(=O)NCCOc1cccc2[nH]c(-c3n[nH]c4cc(C(F)F)ccc34)cc12 CHEMBL4632698 IC50 90.0 nM
O=C(N[C@@H]1CCCN(c2ncnc3[nH]ncc23)C1)[C@H](Nc1cc(Cl)cc(Cl)c1)C1CC1 CHEMBL5207862 Kd 90.0 nM
CN(C(=O)c1ccc2c(c1)nc(NC(=O)c1cccs1)n2CCCO)C1CCCCC1 CHEMBL233365 IC50 92.0 nM
O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)c1ccc(N2CCCCC2)cc1 CHEMBL1765097 Ki 93.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1 CHEMBL4550702 IC50 94.0 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc3ccccc3c1)n2CCC(N)=O CHEMBL480374 IC50 95.0 nM
CC(=O)N1CCN(C(=O)c2cc(CSc3cnc(NC(=O)c4ccc(CNC(CO)C(C)C)cc4)s3)cc(C)c2C)CC1 CHEMBL383129 IC50 96.0 nM
Cc1c(-c2ccc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1cnc2ccccc2c1=O CHEMBL3918580 IC50 96.0 nM
COCC(=O)Nc1ccc2[nH]nc(-c3cc4ccc(OC)cc4[nH]3)c2c1 CHEMBL1684509 IC50 98.0 nM
C=CC(=O)N1CC[C@H](Oc2nc(-c3n[nH]c(=O)[nH]3)cc3ccccc23)C1 CHEMBL5073622 pIC50 99.0 nM