COCCOC1CCCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 CHEMBL3652408 IC50 0.00125 nM
CC(C)COC1CCCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 CHEMBL3652407 IC50 0.00133 nM
C[C@H]1CN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C[C@@H]1CO CHEMBL3652404 IC50 0.00199 nM
C[C@@H]1C[C@@H](CS(=O)(=O)N2CC[C@H](CO)C2)CC[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL3652402 IC50 0.00508 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC(C)(O)C2)CC1 CHEMBL3652406 IC50 0.00777 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(-c4cn[nH]c4)nc3)n2)CCN(C(=O)OCC(F)(F)F)CC1 CHEMBL3896068 IC50 0.01 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CCC(NCC(F)(F)F)CC1 CHEMBL3947540 IC50 0.02 nM
Cn1cc(-c2ccc(Nc3nn([C@H]4COCC[C@@H]4C#N)cc3C(N)=O)cc2)cn1 CHEMBL4078799 IC50 0.02 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@@H](OC(=O)C(C)(C)C)C2)CC1 CHEMBL3652403 IC50 0.0227 nM
CCOP(=O)(OCC)O[C@@H]1CCCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 CHEMBL3652409 IC50 0.0235 nM
CN1CCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)CC1 CHEMBL3652405 IC50 0.0245 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@@H](OP(=O)(O)O)C2)CC1 CHEMBL3652410 IC50 0.0263 nM
Cn1cc(-c2ccc(Nc3nn(C4(CC#N)CCN(C(=O)OCC(F)(F)F)CC4)cc3C(N)=O)cn2)cn1 CHEMBL3929513 IC50 0.03 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(Nc2ccc(F)cc2F)CC1 CHEMBL3904265 IC50 0.03 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(NCc2ccccc2Cl)CC1 CHEMBL3897977 IC50 0.03 nM
N#CC[C@@]1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(C(=O)OCC(F)F)C[C@@H]1F CHEMBL3965448 IC50 0.03 nM
C[C@](O)(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)cc1)C(F)F CHEMBL4113249 IC50 0.03 nM
C[C@@](O)(c1ccc(Nc2nn([C@H]3CC[C@@H](N4CCC4)C[C@@H]3C#N)cc2C(N)=O)cc1)C(F)(F)F CHEMBL3703048 IC50 0.04 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2cccc(O)c2)CC1 CHEMBL3933102 IC50 0.04 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(Nc2ccccc2F)CC1 CHEMBL3950253 IC50 0.04 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CCC(NCC(F)F)CC1 CHEMBL3940414 IC50 0.04 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(NCc2ccccc2)CC1 CHEMBL3959005 IC50 0.04 nM
C[C@@H]1NS(=O)(=O)c2ccc(Nc3nn([C@H]4COCC[C@@H]4C#N)cc3C(N)=O)cc21 CHEMBL4066906 IC50 0.04 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCN(Cc2ccc(C(F)(F)F)cc2)[C@@H](C)C1 CHEMBL5397297 IC50 0.044 nM
CC(C)(C)OC(=O)N1CC[C@](CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)[C@H](F)C1 CHEMBL4106834 IC50 0.05 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(Nc2cccc(F)c2)CC1 CHEMBL3916947 IC50 0.05 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CCC(Nc2ccccc2)CC1 CHEMBL3892599 IC50 0.05 nM
CC(F)(F)C(=O)N1CC[C@@](CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)nc3)n2)[C@@H](F)C1 CHEMBL3972665 IC50 0.05 nM
C[C@@](O)(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)cc1)C(F)F CHEMBL4112743 IC50 0.05 nM
CN(C)C(=O)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL4109943 IC50 0.05 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@H](O)C(F)(F)F)cc2)n1 CHEMBL4089118 IC50 0.05 nM
CN(C(=O)CC#N)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3955948 IC50 0.055 nM
CN(C(=O)Nc1cccc(C#N)c1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3979629 IC50 0.055 nM
CN(C(=O)CCc1c(Cl)cccc1Cl)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3950650 IC50 0.055 nM
CN(C(=O)Nc1ccc(C(F)(F)F)cc1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3975430 IC50 0.055 nM
CN(C(=O)Nc1ccc(Cl)cc1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3949513 IC50 0.055 nM
CN(C(=O)NC1CCOCC1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3966939 IC50 0.055 nM
CN(C(=O)N1CCCC1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3937190 IC50 0.055 nM
COc1nc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)ccc1C#N CHEMBL3951700 IC50 0.055 nM
CN(c1ccc(Cl)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3920484 IC50 0.055 nM
CN(c1ccc(Br)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3959770 IC50 0.055 nM
Cc1cc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)ncc1[N+](=O)[O-] CHEMBL3890701 IC50 0.055 nM
COc1cc2ncnc(N(C)[C@@H]3CCN(c4ncnc5[nH]ccc45)C3)c2cc1OC CHEMBL3897417 IC50 0.055 nM
CN(c1ccc(C#N)cc1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3899672 IC50 0.055 nM
CN(c1ccc(C#N)c(F)c1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL4112580 IC50 0.055 nM
CN(c1cc(F)c(C#N)c(F)c1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3963513 IC50 0.055 nM
CN(c1cccc(C#N)c1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3975138 IC50 0.055 nM
CN(c1ccnc(C#N)c1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3937835 IC50 0.055 nM
CN(c1ccc(S(=O)(=O)C(F)(F)F)cc1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3956529 IC50 0.055 nM
CN(c1ccc(C(F)(F)F)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3959358 IC50 0.055 nM
N#Cc1ccc(N(CC2CC2)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)nc1 CHEMBL3943572 IC50 0.055 nM
CN(c1cc2cn[nH]c2cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3951178 IC50 0.055 nM
C#CCN(c1cnc(C#N)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3923455 IC50 0.055 nM
C#CCN(c1ccc(C#N)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3959909 IC50 0.055 nM
CN(c1ccc(-c2ccncc2)cn1)[C@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3935913 IC50 0.055 nM
CN(c1ccncn1)[C@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3961670 IC50 0.055 nM
Cc1nc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)ccc1C#N CHEMBL3909092 IC50 0.055 nM
CN(c1ccc(-c2nnn[nH]2)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3945908 IC50 0.055 nM
CN(c1ccc(C(=O)NC[C@H](O)c2ccccc2)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3914438 IC50 0.055 nM
CN(c1ccc(NS(=O)(=O)C2=CCCS2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3917937 IC50 0.055 nM
CN(c1ccc(NS(=O)(=O)c2cccnc2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3892184 IC50 0.055 nM
CN(c1ccc(NS(C)(=O)=O)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3939379 IC50 0.055 nM
CC(C)S(=O)(=O)Nc1ccc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)nc1 CHEMBL3965713 IC50 0.055 nM
CN(c1ccc(NS(=O)(=O)Cc2ccccc2F)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3926865 IC50 0.055 nM
CN(c1ccc(S(=O)(=O)N[C@@H]2c3ccccc3C[C@H]2O)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3891549 IC50 0.055 nM
CN(c1ccc(S(N)(=O)=O)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL4113706 IC50 0.055 nM
CN(c1ccc(S(=O)(=O)NC2CC2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3917906 IC50 0.055 nM
COCCNS(=O)(=O)c1ccc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)nc1 CHEMBL3949238 IC50 0.055 nM
CN(c1ccc(S(=O)(=O)NC(C)(C)C)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3912482 IC50 0.055 nM
CNS(=O)(=O)c1ccc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)nc1 CHEMBL3902579 IC50 0.055 nM
CN(c1ccc(S(=O)(=O)NC[C@@H]2CCCO2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3905754 IC50 0.055 nM
CN(c1ccc(S(=O)(=O)NC2COC2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3930305 IC50 0.055 nM
CN(c1ccc(S(=O)(=O)NCCO)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3920398 IC50 0.055 nM
C[C@H](O)CNS(=O)(=O)c1ccc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)nc1 CHEMBL3948216 IC50 0.055 nM
CN(c1ccc(S(=O)(=O)NC2CCC[C@@H]2O)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3932862 IC50 0.055 nM
CN(c1ccc(S(=O)(=O)N2CCCC2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3956880 IC50 0.055 nM
CN(c1ccc(S(=O)(=O)N2CCNCC2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3905903 IC50 0.055 nM
CN(c1ccc(S(=O)(=O)N2CCOCC2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3983040 IC50 0.055 nM
CN(c1ccc(S(=O)(=O)Nc2ccc(F)cc2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3911472 IC50 0.055 nM
CN(c1ccc(S(=O)(=O)NCc2ccc(F)cc2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3917626 IC50 0.055 nM
CN(c1ccc(S(=O)(=O)NC2CCOCC2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3928129 IC50 0.055 nM
CC1(C)CN([C@@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc([C@H](O)C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3703023 IC50 0.06 nM
CC1(C)CN([C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc([C@H](O)C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3703064 IC50 0.06 nM
CC1(C)CN([C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc([C@@](C)(O)C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3703042 IC50 0.06 nM
CC1(C)CN([C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc([C@@H](O)C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3703037 IC50 0.06 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2cccnc2F)CC1 CHEMBL3895272 IC50 0.06 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(C(O)C(F)(F)F)nc3)n2)CCN(C(=O)OCC(F)(F)F)CC1 CHEMBL3984300 IC50 0.06 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ccccc2F)CC1 CHEMBL3945594 IC50 0.06 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(Nc2ccc(Cl)cc2)CC1 CHEMBL3942031 IC50 0.06 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(Nc2ccccc2)CC1 CHEMBL3929641 IC50 0.06 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(-n3ccnn3)cc2)n1 CHEMBL4096821 IC50 0.06 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2cccc(F)c2)CC1 CHEMBL3914149 IC50 0.07 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(C(=O)OCC(F)F)CC1 CHEMBL3946128 IC50 0.07 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(Nc2cccc(Cl)c2)CC1 CHEMBL3893735 IC50 0.07 nM
N#Cc1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL4061128 IC50 0.07 nM
COc1cc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)ccc1C#N CHEMBL4072848 IC50 0.07 nM
O=C(Nc1c[nH]nc1-c1cc2cn[nH]c2cc1OC(F)F)c1cnn2cccnc12 CHEMBL4746726 Ki 0.075 nM
CNC1CCC(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3702973 IC50 0.08 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2ccccn2)CC1 CHEMBL3973424 IC50 0.08 nM
CN(c1ccccc1)C1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1 CHEMBL3914311 IC50 0.08 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CCC(NC2CCOCC2)CC1 CHEMBL3911515 IC50 0.08 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CCC(N2CC(F)C2)CC1 CHEMBL3919665 IC50 0.08 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(NCc2ccccc2F)CC1 CHEMBL3943909 IC50 0.08 nM
N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL1789941 Ki 0.09 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CC1 CHEMBL3935178 IC50 0.09 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)CCC(N2CC(F)C2)CC1 CHEMBL3932064 IC50 0.09 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(Nc2ccccc2)CC1 CHEMBL3950965 IC50 0.09 nM
N#CC[C@]1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC[C@@H](NCc2ccccc2)CC1 CHEMBL3928653 IC50 0.09 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(NCc2ccc(F)cc2F)CC1 CHEMBL3915313 IC50 0.09 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@@H](O)C(F)(F)F)cc2)n1 CHEMBL4111960 IC50 0.09 nM
C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 CHEMBL2386635 Ki 0.1 nM
CS(=O)(=O)c1ccc(Nc2nn([C@H]3CC[C@@H](O)C[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3702957 IC50 0.1 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccccc4)cc23)CC[C@@]1(C)O CHEMBL3671816 IC50 0.1 nM
N#C[C@H]1C[C@H](N2CC3(CCC3)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@@H](O)C(F)(F)F)cc2)n1 CHEMBL3703063 IC50 0.1 nM
CC(C)(c1ccc(Nc2nn([C@@H]3CCCC[C@H]3C#N)cc2C(N)=O)cc1)[C@@H](O)C(F)(F)F CHEMBL3699531 IC50 0.1 nM
N#C[C@H]1C[C@@H](N2CC3(CCC3)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@H](O)C(F)(F)F)cc2)n1 CHEMBL3703059 IC50 0.1 nM
N[C@H]1CC[C@@H](Nc2cc[nH]c(=O)c2-c2nc3ccccc3[nH]2)CC1 CHEMBL3780091 IC50 0.1 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2cncnc2)CC1 CHEMBL3932352 IC50 0.1 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(C)(=O)=O)cc3)n2)CC1 CHEMBL3914600 IC50 0.1 nM
CNC(=O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1 CHEMBL3977608 IC50 0.1 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(N)(=O)=O)cc3)n2)CC1 CHEMBL3949472 IC50 0.1 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(Cl)c3)n2)CC1 CHEMBL3917002 IC50 0.1 nM
CC(C)(O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OCC(F)(F)F)CC3)cc2C(N)=O)cn1 CHEMBL3931250 IC50 0.1 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc4c(c3)CNC4=O)n2)CC1 CHEMBL3965904 IC50 0.1 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(CC(=O)O)cc3)n2)CC1 CHEMBL3900700 IC50 0.1 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ccccc2)CC1 CHEMBL3930900 IC50 0.1 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ccc(F)cc2)CC1 CHEMBL3906618 IC50 0.1 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2cccnc2F)CC1 CHEMBL3944488 IC50 0.1 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ccc(O)cc2)CC1 CHEMBL3927787 IC50 0.1 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ccc(O)nc2)CC1 CHEMBL3905008 IC50 0.1 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ccc(Cl)cc2)CC1 CHEMBL3982398 IC50 0.1 nM
CC(F)(F)C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1 CHEMBL3920186 IC50 0.1 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(C(=O)CCC(F)(F)F)CC1 CHEMBL3981780 IC50 0.1 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)CC(F)(F)F)CC1 CHEMBL3938808 IC50 0.1 nM
CC(C)NC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)CC1 CHEMBL3982094 IC50 0.1 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)CCN(C(=O)Nc2ccc(C#N)cc2)CC1 CHEMBL3922069 IC50 0.1 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)cc3)n2)CCC(N2CC(F)C2)CC1 CHEMBL3938195 IC50 0.1 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CCC(N2CCC(F)(F)CC2)CC1 CHEMBL3983487 IC50 0.1 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc([S+]([O-])C(F)F)cc3)n2)CCC(Nc2cccc(O)c2)CC1 CHEMBL3938031 IC50 0.1 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(Nc2cc(F)ccc2F)CC1 CHEMBL3926188 IC50 0.1 nM
COC1CN(C2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccnc(F)c4)n3)CC2)C1 CHEMBL3923034 IC50 0.1 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(NCc2ccc(Cl)cc2)CC1 CHEMBL3920570 IC50 0.1 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(NCc2ccccc2)CC1 CHEMBL3895727 IC50 0.1 nM
CC1(c2ccc(Nc3nn([C@H]4COCC[C@@H]4C#N)cc3C(N)=O)cc2)COC1 CHEMBL4113190 IC50 0.1 nM
COC(C)(C)c1ccc(Nc2nn([C@@H]3COCC[C@H]3C#N)cc2C(N)=O)cc1 CHEMBL3920418 IC50 0.1 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(OC(F)F)cc2)n1 CHEMBL4102140 IC50 0.1 nM
COc1cc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)ccc1Cl CHEMBL4071005 IC50 0.1 nM
CSc1ccc(OC(F)F)c(-c2n[nH]cc2NC(=O)c2cnc3cccnn23)c1 CHEMBL5268404 Ki 0.1 nM
N#CC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3900105 IC50 0.11 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)c(O)cc1OC(F)F)c1cnn2cccnc12 CHEMBL4789075 Ki 0.11 nM
CC(C)(C(=O)O)c1ccc(Nc2nn([C@@H]3CCCC[C@H]3C#N)cc2C(N)=O)cc1 CHEMBL3699544 IC50 0.12 nM
O=C(Nc1c[nH]nc1-c1cc(Br)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL4742159 Ki 0.12 nM
N#C[C@H]1C[C@@H](N2CC(O)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647728 IC50 0.13 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL4089234 IC50 0.13 nM
N#CCCNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 CHEMBL4563534 IC50 0.14 nM
N#CC[C@H]1CC[C@H](n2c(CC(=O)N3CCC(N4CCOCC4)CC3)nc3cnc4[nH]ccc4c32)CC1 CHEMBL4456630 IC50 0.14 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCN(Cc2ccc(Cl)cc2)[C@@H](C)C1 CHEMBL4783938 IC50 0.145 nM
CC(C)N[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647747 IC50 0.15 nM
C[C@](O)(c1ccc(Nc2nn([C@H]3CC[C@@H](N4CCC4)C[C@@H]3C#N)cc2C(N)=O)cc1)C(F)(F)F CHEMBL3703034 IC50 0.15 nM
CC1(C)CN([C@@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc([C@@](C)(O)C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3703038 IC50 0.15 nM
C[C@@](O)(c1ccc(Nc2nn([C@H]3CC[C@H](N4CCC4)C[C@@H]3C#N)cc2C(N)=O)cc1)C(F)(F)F CHEMBL3703027 IC50 0.15 nM
C[C@@H](N[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1)C1CC1 CHEMBL3647755 IC50 0.15 nM
N#C[C@H]1C[C@@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647741 IC50 0.15 nM
CC(C)(NC1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1)C1CC1 CHEMBL3647781 IC50 0.15 nM
CC1CN([C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(S(=O)(=O)C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3647759 IC50 0.15 nM
N#C[C@@H]1CCCCC1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)CC(F)(F)F)cc2)n1 CHEMBL3647923 IC50 0.15 nM
CC1(O)CN([C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3647771 IC50 0.15 nM
CN(C(C1CC1)C1CC1)[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647751 IC50 0.15 nM
N#C[C@H]1C[C@H](NCC2CC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647746 IC50 0.15 nM
O=C(Nc1cn(CC(=O)N2CC=CCC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3934709 Ki 0.15 nM
O=C(Nc1c[nH]nc1-c1cc(I)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL4764019 Ki 0.15 nM
N#C[C@H]1CCCCC1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)CF)cc2)n1 CHEMBL3702886 IC50 0.16 nM
CS(=O)(=O)NC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3984562 IC50 0.16 nM
CCCCN(C)CC#Cc1nc(-c2cc(Cl)ccc2OC(F)F)c(NC(=O)c2cnn3cccnc23)s1 CHEMBL3946275 Ki 0.16 nM
Cc1ncnc2ccc(Nc3nn([C@H]4COCC[C@@H]4C#N)cc3C(N)=O)cc12 CHEMBL4079092 IC50 0.16 nM
CN(c1ncnc2[nH]ccc12)N1CC[C@@H](C(=O)NCC(F)(F)F)C1 CHEMBL5175400 IC50 0.16 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc3c(c2)CN(CC(F)(F)F)C3=O)n1 CHEMBL3699521 IC50 0.17 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCC(F)(F)C2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3897112 Ki 0.17 nM
CN(C)c1cc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)cc(F)n1 CHEMBL4092626 IC50 0.18 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@@H](O)C(F)(F)F)cc2)n1 CHEMBL3699537 IC50 0.19 nM
O=C(Nc1cn(CC(=O)N2CCC(C(=O)O)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3983256 Ki 0.19 nM
COc1ccnc2c(F)cc(Nc3nn([C@H]4COCC[C@@H]4C#N)cc3C(N)=O)cc12 CHEMBL4088262 IC50 0.19 nM
Nc1nn2cccnc2c1C(=O)Nc1c[nH]nc1-c1cc(Cl)ccc1OC(F)F CHEMBL4740778 Ki 0.19 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(Cl)cc2)[C@H](C)C1 CHEMBL4761365 IC50 0.199 nM
CS(=O)(=O)NCc1nc2cnc3[nH]ccc3c2n1[C@@H]1C[C@H]2CC[C@@H]1C2 CHEMBL2206059 Ki 0.2 nM
N#C[C@H]1C[C@@H](NCC2CC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647745 IC50 0.2 nM
C[C@](O)(c1ccc(Nc2nn([C@H]3CC[C@H](N4CCC4)C[C@@H]3C#N)cc2C(N)=O)cc1)C(F)(F)F CHEMBL3703050 IC50 0.2 nM
N#C[C@H]1C[C@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3650684 IC50 0.2 nM
CCNC1CCC(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3702972 IC50 0.2 nM
CC1(C)CN([C@@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc([C@@H](O)C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3703053 IC50 0.2 nM
N#C[C@H]1C[C@H](N2CC3(CCC3)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@H](O)C(F)(F)F)cc2)n1 CHEMBL3703029 IC50 0.2 nM
CC(C)(C(=O)NCC(F)(F)F)c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3699558 IC50 0.2 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@H](O)C(F)(F)F)nc2)n1 CHEMBL3699551 IC50 0.2 nM
C[C@@](O)(c1ccc(Nc2nn([C@H]3CC[C@H](O)C[C@@H]3C#N)cc2C(N)=O)cc1)C(F)(F)F CHEMBL3647859 IC50 0.2 nM
C[C@H](N[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1)C1CC1 CHEMBL3647757 IC50 0.2 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)NCc3ccccc3)cc2)n1 CHEMBL3702904 IC50 0.2 nM
CC1CN([C@@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(S(=O)(=O)C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3647760 IC50 0.2 nM
CN(C)[C@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3702970 IC50 0.2 nM
N#C[C@H]1C[C@@H](N2CC3(CCC3)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@@H](O)C(F)(F)F)cc2)n1 CHEMBL3703036 IC50 0.2 nM
N#C[C@H]1C[C@H](O)CCC1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647924 IC50 0.2 nM
CC1(C)CN([C@@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc([C@](C)(O)C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3703024 IC50 0.2 nM
N#C[C@H]1CC(NCC(=O)O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647736 IC50 0.2 nM
CC(C)(C)N[C@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647777 IC50 0.2 nM
CC(N[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1)C1CC1 CHEMBL3647749 IC50 0.2 nM
C[C@@H]1[C@H]2CN(S(C)(=O)=O)C[C@H]2C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnc(N)nc3)cc12 CHEMBL3667467 IC50 0.2 nM
C[C@H]1CN(c2ccc(C#N)cn2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC(=O)N4CC(F)(F)C4)c3)cc12 CHEMBL3672453 IC50 0.2 nM
ClC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3954894 IC50 0.2 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(C)(=O)=O)cc3)n2)C1 CHEMBL3916939 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2cncc(F)c2)CC1 CHEMBL3905278 IC50 0.2 nM
COc1cc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)ccn1 CHEMBL3890522 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2ccc(C#N)cc2)CC1 CHEMBL3895654 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2cc(F)ccn2)CC1 CHEMBL3949065 IC50 0.2 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1 CHEMBL3938017 IC50 0.2 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C#N)cc3)n2)CC1 CHEMBL3976977 IC50 0.2 nM
CC(=O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1 CHEMBL3901812 IC50 0.2 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(=O)C(F)(F)F)cc3)n2)CC1 CHEMBL3974477 IC50 0.2 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(N)c3)n2)CC1 CHEMBL3985138 IC50 0.2 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(=O)N4CCOCC4)c(F)c3)n2)CC1 CHEMBL3942917 IC50 0.2 nM
Cc1noc(-c2ccc(Nc3nn(C4(CC#N)CCN(C(=O)OC(C)(C)C)CC4)cc3C(N)=O)cc2)n1 CHEMBL3984315 IC50 0.2 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(C#N)c3)n2)CC1 CHEMBL3938455 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(OC4CCC4)nc3)n2)CCN(C(=O)OCC(F)F)CC1 CHEMBL3971587 IC50 0.2 nM
Cn1cc(-c2cccc(Nc3nn(C4(CC#N)CCN(C(=O)OCC(F)(F)F)CC4)cc3C(N)=O)c2)cn1 CHEMBL3892613 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3cccnc3)n2)CCN(C(=O)OCC(F)(F)F)CC1 CHEMBL3984895 IC50 0.2 nM
COC(=O)Cc1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1 CHEMBL3968445 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2cccnc2)CC1 CHEMBL3949845 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2cncc(F)c2)CC1 CHEMBL3979997 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2cc3ccccc3[nH]2)CC1 CHEMBL3936186 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ccccc2Cl)CC1 CHEMBL3955398 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ccc(C#N)cc2)CC1 CHEMBL3901593 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(C(=O)OCC(F)(F)F)CC1 CHEMBL3905579 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)OCC(F)(F)CO)CC1 CHEMBL3906978 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)CCN(C(=O)OC2COC2)CC1 CHEMBL3924793 IC50 0.2 nM
C[C@H](OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1)C1CC1 CHEMBL3962716 IC50 0.2 nM
N#CCC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1 CHEMBL3933409 IC50 0.2 nM
CC(C)(O)CC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1 CHEMBL3905407 IC50 0.2 nM
CCC(F)(F)C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1 CHEMBL3986976 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(C(=O)CC(F)(F)F)CC1 CHEMBL3899110 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)Nc2ccc(C#N)cc2)CC1 CHEMBL3916587 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(Nc2ccccc2Cl)CC1 CHEMBL3951300 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc([S+]([O-])C(F)F)cc3)n2)CCC(NC2CCCCC2)CC1 CHEMBL3971240 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(Nc2ccc(F)cc2)CC1 CHEMBL3947052 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(Nc2ccccc2F)CC1 CHEMBL3896010 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(N2CCC(F)(F)CC2)CC1 CHEMBL3952669 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(Nc2cccnc2)CC1 CHEMBL3914703 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(N2CC(F)C2)CC1 CHEMBL3980737 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(NCc2ccc(F)cc2)CC1 CHEMBL3937127 IC50 0.2 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccnc(F)c2)n1 CHEMBL4067915 IC50 0.2 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(OC(F)(F)F)cc2)n1 CHEMBL4108565 IC50 0.2 nM
N#C[C@@H]1CCOC[C@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)c(F)c2)n1 CHEMBL3913755 IC50 0.2 nM
CC[C@@H]1CN(c2ccc(C#N)nn2)CC[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC)c3)nc12 CHEMBL3975940 IC50 0.2 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CC[C@@H](O)C2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL4108482 Ki 0.21 nM
O=C(Nc1cn(CCNCc2ccccc2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3921497 Ki 0.21 nM
O=C(Nc1cn(CCNCc2ccccc2O)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3910553 Ki 0.21 nM
O=C(Nc1cn(CCNCc2ccc(O)cc2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3901497 Ki 0.21 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL4744172 Ki 0.21 nM
Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL4777342 Ki 0.21 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)ccc1OC(F)F)c1cnc2cccnn12 CHEMBL4793262 Ki 0.21 nM
N#C[C@H]1CC(NC2COC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647731 IC50 0.22 nM
CC(C)(C#N)CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 CHEMBL4537718 IC50 0.22 nM
CN1CC[C@@H]2[C@H](CCN2C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL4115292 Ki 0.23 nM
O=C(Nc1cn(CC(=O)N2CCC(O)(c3ccncc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3897993 Ki 0.23 nM
O=C(Nc1cn(CC(=O)N2CCC(N3CC[S+]([O-])CC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3893449 Ki 0.23 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC CHEMBL4435170 Kd 0.23 nM
N#C[C@H]1C[C@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3699541 IC50 0.24 nM
CN(Cc1ccc(Cl)c(Cl)c1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3937195 Ki 0.24 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCC(CO)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3964279 Ki 0.24 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CC[C@H](O)C2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3938660 Ki 0.24 nM
O=C(Nc1cn(CC(=O)N2CCC(O)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3963271 Ki 0.24 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCOCC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3912167 Ki 0.24 nM
O=C(Nc1cn(CC(=O)N2CCCCC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3920142 Ki 0.24 nM
CN(CC(C)(C)C#N)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3984319 Ki 0.24 nM
CN(CC1(C#N)CC1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3981690 Ki 0.24 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2cc(F)c3nccc(Cl)c3c2)n1 CHEMBL4076473 IC50 0.24 nM
Cc1nccc(Nc2cc(N[C@@H]3CCN(c4ccc(C#N)cn4)C[C@@H]3F)c(C(N)=O)cn2)n1 CHEMBL4466236 IC50 0.24 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)NCc3ccncc3)cc2)n1 CHEMBL3702907 IC50 0.25 nM
C[C@]1(O)CC[C@H](n2cc(C(N)=O)c(Nc3ccc([C@@](C)(O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647845 IC50 0.25 nM
CS(=O)(=O)c1ccc(Nc2nn([C@H]3CC[C@@H](N4CC5(CCC5)C4)C[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3647722 IC50 0.25 nM
N#C[C@H]1C[C@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@H](O)C(F)(F)F)cc2)n1 CHEMBL3702949 IC50 0.25 nM
N#C[C@H]1C[C@@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3699499 IC50 0.25 nM
N#C[C@H]1C[C@@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647849 IC50 0.25 nM
N#C[C@H]1C[C@@H](NCC(F)F)CCC1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3702979 IC50 0.25 nM
N#C[C@@H]1CCCC[C@H]1n1cc(C(N)=O)c(Nc2ccc3c(c2)CCS3(=O)=O)n1 CHEMBL3639467 IC50 0.25 nM
CC(C)(C(=O)O)c1ccc(Nc2nn([C@H]3CCC(N4CC5(CCC5)C4)C[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3703047 IC50 0.25 nM
COCCNS(=O)(=O)c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3702919 IC50 0.25 nM
CS(=O)(=O)c1ccc(Nc2nn([C@@H]3CCCC[C@H]3C#N)cc2C(N)=O)cc1 CHEMBL3650683 IC50 0.25 nM
CS(=O)(=O)c1ccc(Nc2nn([C@H]3CC[C@H](N4CC5(CCC5)C4)C[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3703096 IC50 0.25 nM
O=C(Nc1cn(CCNCc2cccc(O)c2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3924016 Ki 0.25 nM
CSCCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3912919 Ki 0.25 nM
CC(C#N)CN(C)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3905788 Ki 0.25 nM
N#CC1(NC2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3915972 Ki 0.25 nM
N#CC[C@H]1CC[C@H](n2c(CC(=O)NCC(F)(F)F)nc3cnc4[nH]ccc4c32)CC1 CHEMBL4439418 IC50 0.25 nM
CN[C@@H]1CCC[C@H](n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL4107920 Ki 0.26 nM
CN(Cc1cccc(Br)c1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3931819 Ki 0.27 nM
CC(C)(C#N)CNC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3908154 Ki 0.27 nM
N#C[C@H]1CCCCC1n1cc(C(N)=O)c(Nc2ccc3c(c2)C(O)CS3(=O)=O)n1 CHEMBL3702883 IC50 0.28 nM
CCN(Cc1ccnc(Cl)c1)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3976701 Ki 0.28 nM
CCOC(=O)CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3921546 Ki 0.28 nM
N#C[C@H]1C[C@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647742 IC50 0.29 nM
CN(C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1)C1(CO)CC1 CHEMBL3939892 Ki 0.29 nM
CN(C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1)C1(C#N)CC1 CHEMBL3914162 Ki 0.29 nM
C#Cc1ccc2ncc(C(=O)Nc3c[nH]nc3-c3cc(Cl)ccc3OC(F)F)n2n1 CHEMBL4746416 Ki 0.29 nM
CS(=O)(=O)NCc1nc2cnc3[nH]ccc3c2n1C1CC2CCC1C2 CHEMBL2206638 Ki 0.3 nM
C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CCC#N)CC1 CHEMBL2386636 Ki 0.3 nM
N#C[C@H]1C[C@@H](NC2COC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(CC(F)(F)F)cc2)n1 CHEMBL3703051 IC50 0.3 nM
N#C[C@H]1C[C@H](N2CC(O)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647727 IC50 0.3 nM
[C-]#[N+][C@H]1C[C@@H]([N+]2(C)CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3902006 IC50 0.3 nM
CC(C)NS(=O)(=O)c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3702914 IC50 0.3 nM
N#C[C@H]1C[C@@H](NCc2ccccc2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccnc(F)c2)n1 CHEMBL3703068 IC50 0.3 nM
N#C[C@H]1C[C@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@@H](O)C(F)(F)F)cc2)n1 CHEMBL3702951 IC50 0.3 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)NCc3cccnc3)cc2)n1 CHEMBL3702905 IC50 0.3 nM
CC1(O)CN([C@@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3647772 IC50 0.3 nM
N#C[C@H]1C[C@@H](NCC(F)(F)F)CCC1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)F)cc2)n1 CHEMBL3702977 IC50 0.3 nM
CC(=O)c1ccc(Nc2nn([C@H]3CC[C@H](N4CCC4)C[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3703055 IC50 0.3 nM
N#C[C@H]1C[C@@H](N2CCOCC2)CCC1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3702978 IC50 0.3 nM
CC(C)(C(=O)O)c1ccc(Nc2nn([C@H]3CC[C@@H](N4CCC4)C[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3703052 IC50 0.3 nM
CN(C)[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647761 IC50 0.3 nM
N#C[C@H]1C[C@@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@H](O)C(F)(F)F)cc2)n1 CHEMBL3647856 IC50 0.3 nM
CC(=O)c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3699528 IC50 0.3 nM
N#C[C@H]1C[C@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@H](O)C(F)(F)F)cc2)n1 CHEMBL3703040 IC50 0.3 nM
N#C[C@@H]1CCCC[C@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)F)cc2)n1 CHEMBL3647922 IC50 0.3 nM
CC1(C)CN([C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc([C@](C)(O)C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3703060 IC50 0.3 nM
N#C[C@H]1C[C@@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@H](O)C(F)(F)F)cc2)n1 CHEMBL3703025 IC50 0.3 nM
CCN[C@H]1CC[C@@H](Nc2cc[nH]c(=O)c2-c2nc3ccccc3[nH]2)CC1 CHEMBL3780636 IC50 0.3 nM
C[C@@H]1[C@H]2CN(C(=O)CO)C[C@H]2C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccc(C(N)=O)cc3)cc12 CHEMBL3667469 IC50 0.3 nM
C[C@@H]1[C@H]2CN(C(=O)CO)C[C@H]2C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccc(C(=O)NC4CC4)cc3)cc12 CHEMBL3667474 IC50 0.3 nM
C[C@H]1CN(c2ccc(C#N)cn2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC(=O)N4CCC(F)(F)C4)c3)cc12 CHEMBL3672454 IC50 0.3 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccncc3)n2)CC1 CHEMBL3944048 IC50 0.3 nM
CC(C)(O)c1cccc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)n1 CHEMBL3918566 IC50 0.3 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2cccnc2)CC1 CHEMBL3899162 IC50 0.3 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2cccc(F)n2)CC1 CHEMBL3933330 IC50 0.3 nM
COC(=O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1 CHEMBL3967992 IC50 0.3 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(C)(C)O)cc3)n2)CC1 CHEMBL3938918 IC50 0.3 nM
CN(C)S(=O)(=O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1 CHEMBL3931150 IC50 0.3 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(=O)N4CCOCC4)cc3)n2)CC1 CHEMBL3902563 IC50 0.3 nM
Cc1nc(-c2ccc(Nc3nn(C4(CC#N)CCN(C(=O)OC(C)(C)C)CC4)cc3C(N)=O)cc2)no1 CHEMBL3901465 IC50 0.3 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(C4CCC4)nc3)n2)CCN(C(=O)OCC(F)F)CC1 CHEMBL3945622 IC50 0.3 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(Cc2cccc(O)c2)CC1 CHEMBL3944536 IC50 0.3 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(Cc2ccccc2)CC1 CHEMBL3958399 IC50 0.3 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ccccc2C#N)CC1 CHEMBL3950247 IC50 0.3 nM
COC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)CC1 CHEMBL3958942 IC50 0.3 nM
COCCOC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)CC1 CHEMBL3948300 IC50 0.3 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)OCC(F)(F)F)CC1 CHEMBL3933592 IC50 0.3 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)OC(CF)CF)CC1 CHEMBL3902263 IC50 0.3 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(C(=O)OCC2CC2)CC1 CHEMBL3909471 IC50 0.3 nM
C[C@@H](OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1)C1CC1 CHEMBL4111724 IC50 0.3 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)c2cccs2)CC1 CHEMBL3940586 IC50 0.3 nM
CC(C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1)C(F)(F)F CHEMBL3945985 IC50 0.3 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(C(=O)C2CC(F)(F)C2)CC1 CHEMBL3919061 IC50 0.3 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(S(=O)(=O)c2ccccc2)CC1 CHEMBL3910522 IC50 0.3 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CCC(Nc2cccnc2)CC1 CHEMBL3946481 IC50 0.3 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(Nc2cccc(F)c2)CC1 CHEMBL3927483 IC50 0.3 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(Nc2ccc(F)cc2)CC1 CHEMBL3951181 IC50 0.3 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CCC(N2CCC(O)CC2)CC1 CHEMBL3959238 IC50 0.3 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(NCc2cccc(F)c2)CC1 CHEMBL3970367 IC50 0.3 nM
CN(Cc1ccc(C(C)(C)C)cc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3958691 Ki 0.3 nM
O=C(Nc1cn(CC(=O)N2CCC(O)(c3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3953947 Ki 0.3 nM
COC(=O)CNC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3972612 Ki 0.3 nM
O=C(Nc1cn(CC(=O)N2CCN(Cc3ncco3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3947977 Ki 0.3 nM
C[C@@H](NCCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1)c1ccccc1 CHEMBL4107017 Ki 0.3 nM
N#C[C@H]1CCCN(C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)C1 CHEMBL4111727 Ki 0.3 nM
O=C(Nc1cn(Cc2cn(C3CCN(C4CCOC4)CC3)nn2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3956152 Ki 0.3 nM
CN(C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1)C1COC1 CHEMBL3911166 Ki 0.3 nM
N#C[C@@H]1CCOC[C@H]1n1cc(C(N)=O)c(Nc2ccccc2)n1 CHEMBL3916138 IC50 0.3 nM
CCn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CCN(c5ccc(C#N)nn5)CC4(C)C)c3n2)cn1 CHEMBL3980778 IC50 0.3 nM
Cn1ncc2cc(-c3cn4ncc(C(N)=O)c(N[C@@H]5CN(C(=O)C6(C#N)CC6)C[C@@H]5CF)c4n3)ccc21 CHEMBL3899917 IC50 0.3 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL4104623 IC50 0.3 nM
CC(C)CN1CCC(NC(=O)Cc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)CC1 CHEMBL4514898 IC50 0.3 nM
COc1cc2[nH]ncc2cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12 CHEMBL4755725 Ki 0.3 nM
CN(c1ncnc2[nH]ccc12)N1CCC[C@@H](C(=O)NCC#N)C1 CHEMBL5191898 IC50 0.3 nM
FC(F)(Br)CN[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3943928 IC50 0.31 nM
O=C(Nc1cn(CC(=O)N2CCC(OCCO)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3890657 Ki 0.31 nM
O=C(Nc1cn(CC(=O)N2CCN(Cc3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3951397 Ki 0.31 nM
COC(=O)CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3941118 Ki 0.31 nM
O=C(Nc1cn(CC(=O)N2CCC(N3CCSCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3908409 Ki 0.31 nM
CC(F)(F)CNC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3896662 Ki 0.31 nM
COc1cc(O)c(Cl)cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12 CHEMBL4740223 Ki 0.31 nM
O=C(Nc1c[nH]nc1-c1cc2ccccc2cc1OC(F)F)c1cnn2cccnc12 CHEMBL4745474 Ki 0.31 nM
CC(=O)Nc1cc(Nc2cccc(S(C)(=O)=O)n2)c(-c2ccccn2)cn1 CHEMBL5427277 IC50 0.31 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@H]2C[C@H]3CC[C@@H](C2)N3)c2nc(N)ncc2c1 CHEMBL5076189 pIC50 0.3162 nM
N#C[C@H]1C[C@H](O)CCC1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)F)cc2)n1 CHEMBL3699500 IC50 0.32 nM
N#Cc1cc(F)c(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)c(F)c1 CHEMBL3972475 IC50 0.32 nM
N#Cc1ccc(N2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)cc1 CHEMBL3970070 Ki 0.32 nM
Nc1nn2cccnc2c1C(=O)Nc1cn([C@H]2C[C@@H](N)C2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3901134 Ki 0.32 nM
O=C(O)CCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3951874 Ki 0.32 nM
N#C[C@@H]1CCCC[C@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)NCC3CC3)cc2)n1 CHEMBL3702887 IC50 0.33 nM
SC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3927252 IC50 0.33 nM
[N-]=[N+]=NC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL4111044 IC50 0.33 nM
N#CC1(CN2C[C@@H]3CN(C(=O)Cn4cc(NC(=O)c5cnn6cccnc56)c(-c5cc(Cl)ccc5OC(F)F)n4)C[C@@H]3C2)CCCCC1 CHEMBL3890535 Ki 0.33 nM
CN(CC(C)(F)F)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3970779 Ki 0.33 nM
CC1(O)CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3929644 Ki 0.33 nM
O=C(Nc1cn(CC(=O)N2CCC(O)(CO)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3906168 Ki 0.33 nM
CCN(Cc1cccnc1)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3915560 Ki 0.33 nM
CN(CC1=CC(=O)OC1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3948591 Ki 0.33 nM
CN(C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1)[C@H]1CCOC1 CHEMBL3891615 Ki 0.33 nM
N#C[C@@H]1C[C@@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647932 IC50 0.34 nM
CCCCCC(CC#N)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL3953929 IC50 0.34 nM
CN(CCC#N)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3964801 Ki 0.34 nM
O=C(Nc1cn(CC(=O)N2CCC(CO)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3968781 Ki 0.34 nM
O=C1CCC(CN2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)O1 CHEMBL3956628 Ki 0.34 nM
CN(CC1(CC#N)CC1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3916925 Ki 0.34 nM
CCS(=O)(=O)c1ccc(Nc2nn(C3CCCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3699511 IC50 0.35 nM
CN(C)[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647762 IC50 0.35 nM
CC(C)(c1ccc(Nc2nn([C@H]3CC[C@](C)(O)C[C@@H]3C#N)cc2C(N)=O)cc1)C(O)C(F)(F)F CHEMBL3647835 IC50 0.35 nM
[C-]#[N+][C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(/C(C)=N/OC)cc2)n1 CHEMBL3647919 IC50 0.35 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)Nc3ccncc3)cc2)n1 CHEMBL3702902 IC50 0.35 nM
C[C@@](O)(c1ccc(Nc2nn([C@H]3CC[C@@H](O)C[C@@H]3C#N)cc2C(N)=O)cc1)C(F)(F)F CHEMBL3702953 IC50 0.35 nM
N#C[C@H]1CC(NCCO)CCC1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3702980 IC50 0.35 nM
CC(C)N[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647748 IC50 0.35 nM
CS(=O)(=O)CCNC1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647725 IC50 0.35 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@@H](O)C(F)(F)F)nc2)n1 CHEMBL3699547 IC50 0.35 nM
COCCN1CCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3932570 Ki 0.35 nM
O=C(Nc1cn(CC(=O)N2CCC(F)(F)C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3968315 Ki 0.35 nM
O=C(Nc1cn(CC(=O)N2CCC(N3CCNCC3=O)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3975506 Ki 0.35 nM
CC(C)(c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1)[C@H](O)C(F)(F)F CHEMBL3699530 IC50 0.36 nM
CN(C)CCOC(=O)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3969204 Ki 0.36 nM
O=C1CN(C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CCN1 CHEMBL3956898 Ki 0.36 nM
N#CC1CCN(C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)C1 CHEMBL3920292 Ki 0.36 nM
CN1CCN(C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)C(=O)C1 CHEMBL3957195 Ki 0.36 nM
N#CC1(CNC2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3899109 Ki 0.36 nM
CS(=O)(=O)CCN1C[C@@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@@H]2C1 CHEMBL3904982 Ki 0.37 nM
CSc1ccc(CNCCn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)cc1 CHEMBL3935161 Ki 0.37 nM
O=C(Nc1cn(CC(=O)N2CCC(N3CC4CC(C3)O4)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3906087 Ki 0.37 nM
CC(C)(O)CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 CHEMBL4473572 IC50 0.37 nM
NC(=O)CCN1CCC(n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3921617 Ki 0.38 nM
COCCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3913842 Ki 0.38 nM
CCN(Cc1ccnc(C)c1)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3914623 Ki 0.38 nM
O=C(Nc1cn(CC(=O)N2CCN(N3CCOCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3938720 Ki 0.38 nM
O=C(Nc1cn(CC(=O)N2CCN(C3CCOC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3982408 Ki 0.38 nM
C[C@@H]1COCCN1C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL4107458 Ki 0.38 nM
N#CC1CCN(C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3967830 Ki 0.38 nM
CN1CN([C@H]2CC[C@H](CN3CCCS3(=O)=O)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3984749 IC50 0.38 nM
CC(C)CN1CCC2(CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)C1 CHEMBL3909300 Ki 0.39 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCC(O)(Cc3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3940032 Ki 0.39 nM
CC1(O)CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3947456 Ki 0.39 nM
O=C(Nc1cn(CC2(O)CCCC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3971083 Ki 0.39 nM
O=C(Nc1cn(CC(=O)N2CCC(N3CCC(O)CC3=O)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3896759 Ki 0.39 nM
COC(=O)CCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3909519 Ki 0.39 nM
O=C1CC(N2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CCO1 CHEMBL3957132 Ki 0.39 nM
CNC(=O)CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3932623 Ki 0.39 nM
O=C(Nc1cn(CC(=O)N2CCN(CCN3CCSCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3973184 Ki 0.39 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@H]2CCCN(C)C2)c2nc(N)ncc2c1 CHEMBL5086526 pIC50 0.3981 nM
N#CCC(=O)N1CCC[C@@H](n2cnc3cnc4[nH]ccc4c32)C1 CHEMBL2152300 Ki 0.4 nM
N#C[C@H]1C[C@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(CC(F)(F)F)cc2)n1 CHEMBL3703031 IC50 0.4 nM
N#C[C@H]1CC(NCC2CCS(=O)(=O)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3639465 IC50 0.4 nM
CC(C)(C)N[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc([C@H](O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3703030 IC50 0.4 nM
N#C[C@H]1CCCCC1n1cc(C(N)=O)c(Nc2ccc3c(c2)CCS3(=O)=O)n1 CHEMBL3702930 IC50 0.4 nM
CN(C)[C@@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3650674 IC50 0.4 nM
CC(=O)c1ccc(Nc2nn([C@H]3CC[C@@H](N4CCC4)C[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3703054 IC50 0.4 nM
[C-]#[N+][C@H]1C[C@@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3702982 IC50 0.4 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)N3CCOCC3)cc2)n1 CHEMBL3702920 IC50 0.4 nM
CC1(CN[C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(C(F)(F)F)cc4)n3)[C@@H](C#N)C2)COC1 CHEMBL3703006 IC50 0.4 nM
CN(C)[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(OC(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3703073 IC50 0.4 nM
N#C[C@H]1CC(NC2CCS(=O)(=O)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647729 IC50 0.4 nM
CC(C)(O)C1CN([C@@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3702987 IC50 0.4 nM
N#C[C@@H]1CCCC[C@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)NCCN3CCOCC3)cc2)n1 CHEMBL3702889 IC50 0.4 nM
N[C@H]1CC[C@@H](Nc2cc[nH]c(=O)c2-c2nc3c([nH]2)CCC(C(F)F)C3)CC1 CHEMBL3781442 IC50 0.4 nM
CNC(=O)c1ccc(-c2cc3c(N[C@@H]4C[C@@H]5CN(C(=O)C(C)(C)O)C[C@@H]5[C@H]4C)c(C(N)=O)cnn3c2)cn1 CHEMBL3667471 IC50 0.4 nM
CNC(=O)Cn1cc(-c2cc3c(N[C@@H]4CN(c5ccc(Cl)cn5)C[C@@H]4C)c(C(N)=O)cnn3c2)cn1 CHEMBL3672474 IC50 0.4 nM
BrC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3918308 IC50 0.4 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2ccc(F)nc2)CC1 CHEMBL3977196 IC50 0.4 nM
Cc1ccc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)cn1 CHEMBL3963918 IC50 0.4 nM
COc1ccc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)cn1 CHEMBL3933722 IC50 0.4 nM
CC(O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1 CHEMBL3960876 IC50 0.4 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(C(F)(F)F)c3)n2)CC1 CHEMBL3939638 IC50 0.4 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C#N)c(F)c3)n2)CC1 CHEMBL3953347 IC50 0.4 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(C(N)=O)c3)n2)CC1 CHEMBL3924220 IC50 0.4 nM
N#CCC1(n2cc(C(N)=O)c(Nc3cccc(-c4cc[nH]n4)c3)n2)CCN(C(=O)OCC(F)(F)F)CC1 CHEMBL3924108 IC50 0.4 nM
N#CCC1(n2cc(C(N)=O)c(Nc3cncc(Cl)c3)n2)CCN(C(=O)OCC(F)(F)F)CC1 CHEMBL3914049 IC50 0.4 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnnc3)n2)CC1 CHEMBL3897371 IC50 0.4 nM
Cc1cnc(F)c(CN2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccnc(F)c4)n3)CC2)c1 CHEMBL3981942 IC50 0.4 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(Cc2cccnc2)CC1 CHEMBL3922288 IC50 0.4 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2cccc(Cl)c2)CC1 CHEMBL3967309 IC50 0.4 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2ccncn2)CC1 CHEMBL3889909 IC50 0.4 nM
CC(CO)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1 CHEMBL3958861 IC50 0.4 nM
CS(=O)(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1 CHEMBL3906783 IC50 0.4 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(S(=O)(=O)C2CC2)CC1 CHEMBL3903172 IC50 0.4 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CCC(Nc2ccccc2O)CC1 CHEMBL3935010 IC50 0.4 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(C(=O)O[C@H]2CCOC2)CC1 CHEMBL3980102 IC50 0.4 nM
N#CCCNC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3963191 Ki 0.4 nM
CN(CC(F)(F)F)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3890537 Ki 0.4 nM
CSCCNCCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3958243 Ki 0.4 nM
O=C(Nc1cn(CC(=O)N2CCN(CCN3CCOCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3965809 Ki 0.4 nM
O=C(Nc1cn(CC(=O)N2CCC(CN3CCOCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3942091 Ki 0.4 nM
CN1CCC(COC(=O)C2(C)CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3924292 Ki 0.4 nM
O=C1CC(N2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CO1 CHEMBL3914221 Ki 0.4 nM
CN(C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1)[C@@H]1CCOC1 CHEMBL4112987 Ki 0.4 nM
CN1CCC(n2cc(Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)nn2)CC1 CHEMBL3984799 Ki 0.4 nM
N#CCCCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3964990 Ki 0.4 nM
N#C[C@@H]1CCOC[C@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)c(Cl)c2)n1 CHEMBL3923812 IC50 0.4 nM
Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(c5ccc(C#N)cn5)CC4C3)n2)cn1 CHEMBL3943922 IC50 0.4 nM
N#CCC(=O)N1CCC2(CCC(Nc3nc(Nc4cnn(CC5CC5)c4)ncc3Cl)CC2)CC1 CHEMBL3960628 IC50 0.4 nM
Cn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CCN(c5ccc(C#N)nn5)CC4(C)C)c3n2)cn1 CHEMBL3905150 IC50 0.4 nM
N#CC1(C(=O)N2C[C@H](CF)[C@H](Nc3c(C(N)=O)cnn4cc(-c5ccc6c(c5)NC(=O)C6)nc34)C2)CC1 CHEMBL3982270 IC50 0.4 nM
CCc1cc(O)ccc1-c1ccc2c(-c3nc4ccccc4[nH]3)n[nH]c2c1 CHEMBL3928932 IC50 0.4 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccccc2)n1 CHEMBL4100288 IC50 0.4 nM
N#Cc1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)cc1Cl CHEMBL4085737 IC50 0.4 nM
COc1cc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)cc(F)n1 CHEMBL4066193 IC50 0.4 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccccc4)cc23)CC[C@]1(C)N CHEMBL4096145 IC50 0.4 nM
O=C(Nc1cn(CC(=O)N2CCC3(CCN(CC4CCN(C(=O)OCc5ccccc5)CC4)C3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3891254 Ki 0.41 nM
O=C(Nc1cn(CC(=O)N2CCN(c3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3898868 Ki 0.41 nM
CN(C)C(=O)CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3961154 Ki 0.41 nM
CC1(C(=O)OCCN2CCOCC2)CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3958970 Ki 0.41 nM
O=C(O)CNC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3937898 Ki 0.41 nM
CN1CCN(C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1=O CHEMBL3922831 Ki 0.41 nM
CC(C#N)CNC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3940217 Ki 0.41 nM
O=C(Nc1cn(CC(=O)N2CCC(OCC(=O)N3CCOCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3981642 Ki 0.41 nM
CN(C)C(=O)CN1CCN(CC2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3928573 Ki 0.42 nM
CN(CC1OCCO1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3923151 Ki 0.42 nM
CN1CN([C@H]2CC[C@H](CNS(=O)(=O)CC(F)(F)F)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3947242 IC50 0.42 nM
CN(C)CC1(c2ccccc2)CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3900004 Ki 0.43 nM
CN1CCN(CC2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3943256 Ki 0.43 nM
Cc1cc2cnc3[nH]ccc3c2n1[C@H]1CN(C(=O)CC#N)CC[C@H]1C CHEMBL5284762 IC50 0.43 nM
CN1CCN(CCCN2CCC(n3cc(NC(=O)c4c(N)nn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)C1=O CHEMBL3949394 Ki 0.44 nM
O=C(Nc1cn(CC(=O)N2CCC3(CCNC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3915865 Ki 0.44 nM
CN(C)CCOC(=O)C1(C)CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3978448 Ki 0.44 nM
N#C[C@H]1CCCCC1n1cc(C(N)=O)c(Nc2ccc3c(c2)C=CS3(=O)=O)n1 CHEMBL3702884 IC50 0.45 nM
CC(C)(C(=O)O)c1ccc(Nc2nn([C@H]3CCC(N4CCC4)C[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3703046 IC50 0.45 nM
COC(C)(C)c1ccc(Nc2nn([C@H]3CC[C@@H](O)C[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3702947 IC50 0.45 nM
N#C[C@H]1C[C@@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@@H](O)C(F)(F)F)cc2)n1 CHEMBL3647857 IC50 0.45 nM
COC1CN(C2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(S(=O)(=O)C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3647724 IC50 0.45 nM
N#C[C@H]1C[C@@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C=O)cc2)n1 CHEMBL3703041 IC50 0.45 nM
C[C@](O)(c1ccc(Nc2nn([C@H]3CC[C@H](O)C[C@@H]3C#N)cc2C(N)=O)cc1)C(F)(F)F CHEMBL3647858 IC50 0.45 nM
N#C[C@H]1C[C@H](N2CC(F)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3703080 IC50 0.45 nM
[C-]#[N+][C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(/C=N/OC)cc2)n1 CHEMBL3647918 IC50 0.45 nM
N#C[C@H]1C[C@@H](NCC2(O)CC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3703003 IC50 0.45 nM
N#C[C@H]1C[C@@H](NCC(F)F)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647738 IC50 0.45 nM
CN(CC1Oc2ccccc2O1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3934132 Ki 0.45 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(CCCN3CCCC3=O)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3976610 Ki 0.45 nM
CS(=O)(=O)CCCN1CCC(n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3979537 Ki 0.45 nM
N#Cc1ccc(CN2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)cc1 CHEMBL3935981 Ki 0.45 nM
O=C(Nc1cn(CC(=O)N2CCN(CC3CC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3896141 Ki 0.45 nM
C[C@H](NCCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1)c1ccccc1 CHEMBL3897920 Ki 0.45 nM
N#CC1CN(C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)C1 CHEMBL3920585 Ki 0.45 nM
C[C@H]1COCCN1C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3956219 Ki 0.45 nM
O=C(Nc1cn(Cc2cn(C3CCN(C4CCOCC4)CC3)nn2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3948039 Ki 0.45 nM
CS(=O)(=O)CCCN1C[C@@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@@H]2C1 CHEMBL3926308 Ki 0.46 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CCCN4CCOC4=O)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3961393 Ki 0.46 nM
CN(CCO)C1CCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3889937 Ki 0.46 nM
O=C1C=C(CN2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CO1 CHEMBL3972830 Ki 0.46 nM
N#CCCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3932881 Ki 0.46 nM
CN1CCCC2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC21 CHEMBL3950981 Ki 0.46 nM
CSc1ccc(Cl)cc1-c1nn(C)cc1NC(=O)c1cnn2cccnc12 CHEMBL4750979 Ki 0.46 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1n1ccc2cnc3[nH]ccc3c21 CHEMBL5281283 IC50 0.46 nM
N#C[C@@H]1CCN(C(=O)[C@H](NC(=O)c2c[nH]c3ncc(C4CC4)nc23)C2CC2)C1 CHEMBL2325897 IC50 0.47 nM
O=C(Nc1cn(CC(=O)N2CC[C@H]3CNC[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3892055 Ki 0.47 nM
CS(=O)(=O)N1CCC(CN2C[C@@H]3CN(C(=O)Cn4cc(NC(=O)c5cnn6cccnc56)c(-c5cc(Cl)ccc5OC(F)F)n4)C[C@@H]3C2)CC1 CHEMBL3890487 Ki 0.47 nM
O=C(Nc1cn(CC(=O)N2CCN(CCO)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3911942 Ki 0.47 nM
O=C(Nc1cn(CC(=O)N2CCN(CC3CCOCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3981187 Ki 0.47 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)ccc1OC(F)F)c1snc2cccnc12 CHEMBL4788860 Ki 0.47 nM
N#CC1(c2ccccc2)CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3973547 Ki 0.48 nM
CC(c1ccccc1)N1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3974475 Ki 0.48 nM
O=C(Nc1cn(CC(=O)N2CCN(C3CCOCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3909510 Ki 0.48 nM
N#C[C@H]1CCCCC1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)CC(F)(F)F)cc2)n1 CHEMBL3699513 IC50 0.49 nM
CN1CC[C@H](n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3890200 Ki 0.49 nM
CN1CC[C@@H](n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL4108502 Ki 0.49 nM
CN1CCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3926009 Ki 0.49 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCN(CCO)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3925958 Ki 0.49 nM
O=C(Nc1cn(CC(=O)N2CCC[C@H]2CO)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3929573 Ki 0.49 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCOC(CO)C2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3979963 Ki 0.49 nM
NCCn1cc(NC(=O)c2c(N)nn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3933199 Ki 0.49 nM
CCOC(=O)CCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3915926 Ki 0.49 nM
O=C(Nc1cn(CC(=O)N2CCC(C(=O)OCCN3CCOCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3922554 Ki 0.49 nM
O=C(Nc1cn(CC(=O)N2CCC(N3C[C@@H]4C[C@H]3CO4)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3892587 Ki 0.49 nM
N#CCCCNC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3899912 Ki 0.49 nM
CN(CCCC#N)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3959085 Ki 0.49 nM
NC(=O)c1cnc2[nH]ccc2c1NC1C2CC3CC1CC(O)(C3)C2 CHEMBL4238926 IC50 0.49 nM
N#CC[C@H]1CC[C@H](n2c(CC(=O)NCc3ccc(F)cc3)nc3cnc4[nH]ccc4c32)CC1 CHEMBL4588333 IC50 0.49 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1n1cnc2cnc3[nH]ccc3c21 CHEMBL2152297 Ki 0.5 nM
CS(=O)(=O)c1ccc(Nc2nn([C@H]3CCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3699461 IC50 0.5 nM
COc1ccc(Cl)cc1-c1nn(CC(=O)N2CC=CCC2)cc1NC(=O)c1cnn2cccnc12 CHEMBL3667523 Ki 0.5 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)NC3CCCCC3)cc2)n1 CHEMBL3702903 IC50 0.5 nM
N#C[C@H]1C[C@@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(OC(F)(F)F)cc2)n1 CHEMBL3647848 IC50 0.5 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)NCc3ccccc3Cl)cc2)n1 CHEMBL3702912 IC50 0.5 nM
N#Cc1ccc(Nc2nn([C@H]3CC[C@H](O)C[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3647852 IC50 0.5 nM
N#C[C@H]1C[C@@H](N2CC3(CCC3)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccnc(F)c2)n1 CHEMBL3703098 IC50 0.5 nM
N#C[C@H]1C[C@@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(OC(F)F)cc2)n1 CHEMBL3703072 IC50 0.5 nM
CC(=O)N1CCN(S(=O)(=O)c2ccc(Nc3nn([C@H]4CCCC[C@@H]4C#N)cc3C(N)=O)cc2)CC1 CHEMBL3702910 IC50 0.5 nM
N#C[C@H]1CCCCC1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)F)cc2)n1 CHEMBL3699510 IC50 0.5 nM
N#C[C@H]1C[C@@H](NCC(F)F)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)F)cc2)n1 CHEMBL3703093 IC50 0.5 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)NCCN3CCCC3)cc2)n1 CHEMBL3702908 IC50 0.5 nM
CC(C)(c1ccc(Nc2nn([C@H]3CC[C@H](O)C[C@@H]3C#N)cc2C(N)=O)cc1)C(O)C(F)(F)F CHEMBL3647861 IC50 0.5 nM
CS(=O)(=O)N[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3647915 IC50 0.5 nM
O=c1[nH]ccc(N[C@H]2CC[C@@H](NCCF)CC2)c1-c1nc2ccccc2[nH]1 CHEMBL3781359 IC50 0.5 nM
C[C@H]1CN(C(=O)CC#N)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccnc(F)c3)cc12 CHEMBL3672456 IC50 0.5 nM
CC[C@H]1CN(S(C)(=O)=O)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC(C)C)c3)cc12 CHEMBL3672460 IC50 0.5 nM
CNC(=O)c1cccc(-c2cc3c(N[C@@H]4CN(C(=O)C5(C#N)CC5)C[C@@H]4OC)c(C(N)=O)cnn3c2)c1 CHEMBL3672466 IC50 0.5 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(Br)cc3)n2)CC1 CHEMBL3922934 IC50 0.5 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cccc(Cn4nnc5ccccc54)c3)n2)CC1 CHEMBL3905904 IC50 0.5 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(=O)N4CCS(=O)(=O)CC4)cc3)n2)CC1 CHEMBL3935508 IC50 0.5 nM
N#CCC1(n2cc(C(N)=O)c(Nc3cccc(Cn4nnc5ccccc54)c3)n2)CCN(C(=O)OCC(F)(F)F)CC1 CHEMBL3957158 IC50 0.5 nM
CC(O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cn1 CHEMBL3968473 IC50 0.5 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C#N)nc3)n2)CC1 CHEMBL3896338 IC50 0.5 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cccnc3)n2)CC1 CHEMBL3922799 IC50 0.5 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)CCN(C(=O)OCC(F)(F)F)CC1 CHEMBL3942252 IC50 0.5 nM
COc1cccc(CN2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccnc(F)c4)n3)CC2)c1 CHEMBL3959656 IC50 0.5 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)OCC(F)F)CC1 CHEMBL3893287 IC50 0.5 nM
CS(=O)(=O)CC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1 CHEMBL3911822 IC50 0.5 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(NC2CCCCC2)CC1 CHEMBL3890345 IC50 0.5 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc([S+]([O-])C(F)F)cc3)n2)CCC(Nc2ccc(O)cc2)CC1 CHEMBL3902507 IC50 0.5 nM
CN1CC[C@@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@@H]2C1 CHEMBL4106670 Ki 0.5 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CC(F)(F)F)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3922782 Ki 0.5 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCC(N3CC[C@@H](O)C3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL4115299 Ki 0.5 nM
CCCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3891057 Ki 0.5 nM
CN1CCN(C(=O)C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3937016 Ki 0.5 nM
N#C[C@@H]1CCN(Cc2cncs2)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3912265 IC50 0.5 nM
N#C[C@@H]1CS(=O)(=O)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL4110575 IC50 0.5 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2cnc3cc(Cl)ccc3c2)n1 CHEMBL4109202 IC50 0.5 nM
N#C[C@@H]1CCOC[C@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)nc2)n1 CHEMBL3938373 IC50 0.5 nM
N#C[C@@H]1CCOC[C@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)F)nc2)n1 CHEMBL3934877 IC50 0.5 nM
C[C@]1(C#N)CS(=O)(=O)CC1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3972345 IC50 0.5 nM
N#CCC(=O)N1CC2CC(Nc3nc(Nc4cnn(CC5CC5)c4)ncc3Cl)CC2C1 CHEMBL3985871 IC50 0.5 nM
CCc1cc(O)ccc1-c1ccc2c(-c3nc4c([nH]3)CN(C(C)=O)CC4)n[nH]c2c1 CHEMBL4093813 IC50 0.5 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C3CC3)cc2)n1 CHEMBL4077886 IC50 0.5 nM
COc1ccccc1-c1cc2c(N[C@@H]3CC[C@](C)(N)C3(C)C)c(C(N)=O)cnn2c1 CHEMBL4071255 IC50 0.5 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL221959 IC50 0.5 nM
COc1cc(-c2ccc(O)cc2)cc2cnc(Nc3cnn(C)c3)nc12 CHEMBL5084861 pIC50 0.5012 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@@H](C)CO)c2nc(N)ncc2c1 CHEMBL5078647 pIC50 0.5012 nM
CCc1cc(O)c(F)cc1-c1cc(NC[C@H](C)O)c2nc(N)ncc2c1 CHEMBL5078141 pIC50 0.5012 nM
O=C(Nc1cn(CC(=O)N2CC[C@@H]3CNCC[C@@H]32)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL4112868 Ki 0.51 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CC4CCN(C(=O)C5CCOCC5)CC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3918538 Ki 0.51 nM
CC1(CN(CCC(F)(F)F)C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)COC1 CHEMBL3923871 Ki 0.51 nM
O=C(Nc1cn(CC(=O)N2CCOC(CO)C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3962342 Ki 0.51 nM
CN1CCC(COC(=O)C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3892798 Ki 0.51 nM
CN1CCC2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC21 CHEMBL3983983 Ki 0.51 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)ccc1OC(F)F)c1cncc2scnc12 CHEMBL4780070 Ki 0.51 nM
CN(CC1(C#N)CCCCC1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3921728 Ki 0.52 nM
O=C(Nc1cn(CC(=O)N2CCC(N3Cc4ccc(Cl)cc4C3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3941221 Ki 0.52 nM
CN(C)C1CN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3932430 Ki 0.52 nM
CN[C@H]1C[C@@H](n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3977237 Ki 0.52 nM
O=C(O)CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3908328 Ki 0.52 nM
O=C(Nc1cn(CC(=O)N2CCC(N3CCCOCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3905858 Ki 0.52 nM
CNC(=O)c1nnc(NC(=O)C2CC2)c2[nH]c(-c3ccc(N)cc3OC)cc12 CHEMBL5424497 Kd 0.52 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C=O)cc2)n1 CHEMBL3699526 IC50 0.53 nM
O=C(Nc1cn(CC(=O)N2C[C@@H]3CN(C(=O)OCCCO)C[C@@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3959266 Ki 0.53 nM
CN(C)CCOC1CCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3970998 Ki 0.53 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(CCCC(=O)NCc3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3980959 Ki 0.53 nM
O=C(Nc1cn(CC(=O)N2CCC(C(=O)OCC3CCNCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3907971 Ki 0.53 nM
CNC(=O)[C@@H]1CCCN1C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3900605 Ki 0.53 nM
CCc1ccc(OC(F)F)c(-c2n[nH]cc2NC(=O)c2cnn3cccnc23)c1 CHEMBL4757833 Ki 0.53 nM
CN1C[C@@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@]2(c2ccccc2)C1 CHEMBL4112986 Ki 0.54 nM
CN(C)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3956075 Ki 0.54 nM
CC(=O)N1CCC(N2CCC(n3cc(NC(=O)c4c(N)nn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3904335 Ki 0.54 nM
CN1CCC2(CC1)CCN(C(=O)Cn1cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n1)C2 CHEMBL3943816 Ki 0.54 nM
O=C(Nc1cn(CC(=O)N2CCN(CCOCCO)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3967093 Ki 0.54 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCC(O)(c3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3893713 Ki 0.54 nM
O=C(Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1)NCC1(CO)CC1 CHEMBL3945218 Ki 0.54 nM
N#CC[C@H]1CC[C@H](n2c(CC(=O)NC34CCC(C(N)=O)(CC3)CC4)nc3cnc4[nH]ccc4c32)CC1 CHEMBL4447497 IC50 0.54 nM
COC[C@H](C(=O)Nc1cccc2c(-c3nc(Nc4cccc(S(C)(=O)=O)c4F)ncc3F)c[nH]c12)N1CCN(C)CC1 CHEMBL4447181 IC50 0.54 nM
CN(C)[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3703085 IC50 0.55 nM
N#Cc1ccc(Nc2nn([C@H]3CC[C@@H](O)C[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3702941 IC50 0.55 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2cnc3c(c2)CNC3=O)n1 CHEMBL3702897 IC50 0.55 nM
CN([C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1)C(C)(C)C CHEMBL3702986 IC50 0.55 nM
N#C[C@H]1C[C@@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@@H](O)C(F)(F)F)cc2)n1 CHEMBL3703058 IC50 0.55 nM
N#C[C@H]1C[C@@H](NCC(F)(F)F)CCC1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3702976 IC50 0.55 nM
CC1(CN2C[C@@H]3CN(C(=O)Cn4cc(NC(=O)c5cnn6cccnc56)c(-c5cc(Cl)ccc5OC(F)F)n4)C[C@@H]3C2)COC1 CHEMBL3929734 Ki 0.55 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(CCCC(=O)N3CCOCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3909533 Ki 0.55 nM
CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3950688 Ki 0.55 nM
CCN1CCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3912892 Ki 0.55 nM
N#CC1(c2ccccc2)CCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3934963 Ki 0.55 nM
CN1CCN(C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3968155 Ki 0.55 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CCCN4CCCC4=O)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3914541 Ki 0.56 nM
O=C(Nc1cn(CC(=O)N2CCC3(CNC3)C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3930303 Ki 0.56 nM
CN1CCC2(CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)C1 CHEMBL3933698 Ki 0.56 nM
CN(C)C1CCN(C(=O)c2ccc(-c3nc(-c4cc(Cl)ccc4OC(F)F)c(NC(=O)c4cnn5cccnc45)s3)cc2)CC1 CHEMBL3921881 Ki 0.56 nM
CN(C)Cc1ccc(-c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)cc1 CHEMBL3946308 Ki 0.56 nM
CC1(CN2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)COC1 CHEMBL3960123 Ki 0.56 nM
CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C(C)(C)C1 CHEMBL3933811 Ki 0.56 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)ccc1OC(F)F)c1cncc2c[nH]nc12 CHEMBL4760562 Ki 0.56 nM
O=C(Nc1c[nH]nc1-c1c(OC(F)F)ccc(Cl)c1F)c1cnn2cccnc12 CHEMBL4756876 Ki 0.56 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(C(F)(F)F)cc2)[C@H](C)C1 CHEMBL5398372 IC50 0.563 nM
CCCCC(CC#N)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL3919101 IC50 0.57 nM
O=C(Nc1cn(CC(=O)N2CCC(NC(c3ccccc3)C(F)(F)F)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3956283 Ki 0.57 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(CCCNC(=O)c3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3935850 Ki 0.57 nM
CN(CCC#N)C1CCC(=CCn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3933766 Ki 0.57 nM
COc1ccc(Cl)cc1-c1nn(C)cc1NC(=O)c1cnn2cccnc12 CHEMBL2178801 Ki 0.57 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCN(Cc2ccc(C#N)nc2)[C@@H](C)C1 CHEMBL5413283 IC50 0.577 nM
CNC(=O)c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3639983 IC50 0.58 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CC4(O)CCCCC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3979546 Ki 0.58 nM
NC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3910787 Ki 0.58 nM
CC(=O)N1CCC(CN2CCC(n3cc(NC(=O)c4c(N)nn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3914617 Ki 0.58 nM
CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C[C@@H]1CO CHEMBL4113953 Ki 0.58 nM
CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C[C@H]1CO CHEMBL3952702 Ki 0.58 nM
O=C(Nc1cn(CC(=O)N2CCOCC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3901982 Ki 0.58 nM
CN(C)C(=O)CN(C)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3931538 Ki 0.58 nM
N#C[C@H]1CCN(C(=O)[C@H](NC(=O)c2c[nH]c3ncc(C4CC4)nc23)C2CC2)C1 CHEMBL2325898 IC50 0.59 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2C[C@H]3CN(CC4CC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3950143 Ki 0.59 nM
NC(=O)CCCN1CCC(n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3937077 Ki 0.59 nM
Nc1nn2cccnc2c1C(=O)Nc1cn([C@@H]2CCNC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL4114441 Ki 0.59 nM
COC(=O)CCN(C)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3970778 Ki 0.59 nM
O=C(Nc1cn(CC(=O)N2CCC(C(=O)N3CCNCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3892301 Ki 0.59 nM
CN(CC1(C)OCCO1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3907006 Ki 0.59 nM
N#CCCN1CCC(n2cnc3cnc4[nH]ccc4c32)CC1 CHEMBL2152401 Ki 0.6 nM
CS(=O)(=O)NCCc1nc2cnc3[nH]ccc3c2n1C1CC2CCC1C2 CHEMBL2206639 Ki 0.6 nM
O=C(NCCc1ccn(-c2ccccc2)n1)c1ccc(-c2cccc3nc(NC(=O)C4CC4)nn23)cc1 CHEMBL3360349 IC50 0.6 nM
COCCN(C)[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647726 IC50 0.6 nM
CC(C)(c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1)[C@@H](O)C(F)(F)F CHEMBL3699532 IC50 0.6 nM
CN(C)C(=O)c1ccc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)cc1 CHEMBL3671810 IC50 0.6 nM
CC(C)(O)C1CN([C@@H]2CCC(n3cc(C(N)=O)c(Nc4ccc(Cl)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3647785 IC50 0.6 nM
N#C[C@H]1C[C@@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(CC(F)(F)F)cc2)n1 CHEMBL3703043 IC50 0.6 nM
N#C[C@H]1C[C@@H](N2C[C@@H]3[C@@H](CO)[C@@H]3C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3703013 IC50 0.6 nM
N#C[C@H]1C[C@H](N2CC3(CCC3)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3703004 IC50 0.6 nM
CS(=O)(=O)c1ccc(Nc2nn(C3CCCCC3C#N)cc2C(N)=O)cc1 CHEMBL3699477 IC50 0.6 nM
C[C@](O)(c1ccc(Nc2nn([C@H]3CC[C@@H](O)C[C@@H]3C#N)cc2C(N)=O)cc1)C(F)(F)F CHEMBL3702944 IC50 0.6 nM
N#C[C@H]1C[C@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(OC(F)F)cc2)n1 CHEMBL3702956 IC50 0.6 nM
N#C[C@H]1C[C@@H](NC(C2CC2)C2CC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647753 IC50 0.6 nM
N[C@H]1CC[C@H](Nc2cc[nH]c(=O)c2-c2nc3ccccc3[nH]2)CC1 CHEMBL3779913 IC50 0.6 nM
CC(C)(C)OC(=O)N1CC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(C)(=O)=O)cc3)n2)C1 CHEMBL4107213 IC50 0.6 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2ccc(OC(F)F)cn2)CC1 CHEMBL3942738 IC50 0.6 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2cncc(C#N)c2)CC1 CHEMBL3948069 IC50 0.6 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2ccc(C(F)(F)F)nc2)CC1 CHEMBL3984504 IC50 0.6 nM
COc1cncc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)c1 CHEMBL3948102 IC50 0.6 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cccc(Cn4ccnc4)c3)n2)CC1 CHEMBL3920686 IC50 0.6 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2cnccn2)CC1 CHEMBL3891090 IC50 0.6 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(Cc2cc(F)ccn2)CC1 CHEMBL3939808 IC50 0.6 nM
CC(C)(C)CC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1 CHEMBL3891000 IC50 0.6 nM
CS(=O)(=O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)CC#N)CC3)cc2C(N)=O)cc1 CHEMBL3915901 IC50 0.6 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(S(=O)(=O)c2ccco2)CC1 CHEMBL3929554 IC50 0.6 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(S(=O)(=O)c2cccc(Cl)c2)CC1 CHEMBL3917637 IC50 0.6 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(Nc2ccc(Cl)cc2)CC1 CHEMBL3950370 IC50 0.6 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(NCc2cccc(Cl)c2)CC1 CHEMBL3956020 IC50 0.6 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(C(=O)O[C@@H]2CCOC2)CC1 CHEMBL4111034 IC50 0.6 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2C[C@H]3CN(CC4CCC(F)(F)CC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3963779 Ki 0.6 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCC(N3CC[C@H](O)C3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3942542 Ki 0.6 nM
CN(C)C1CCN(C(=O)c2ccc(-n3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)cc2)CC1 CHEMBL3900032 Ki 0.6 nM
CC1(N2CCOCC2)CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3981362 Ki 0.6 nM
CNC(=O)[C@@H]1CCCN1CC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3962975 Ki 0.6 nM
Cc1ncoc1CN1CC[C@@H](C#N)[C@H](n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1 CHEMBL3917134 IC50 0.6 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(OCC(F)(F)F)nc2)n1 CHEMBL4113597 IC50 0.6 nM
Cc1nn(C)cc1-c1cn2ncc(C(N)=O)c(N[C@H]3CN(C(=O)C4(C#N)CC4)C[C@H]3C)c2n1 CHEMBL3939580 IC50 0.6 nM
CN([C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1)C1(C)COC1 CHEMBL4094682 IC50 0.6 nM
COc1ccc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)cc1 CHEMBL4078773 IC50 0.6 nM
Cc1cc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)ccn1 CHEMBL4073562 IC50 0.6 nM
COc1ccc(Cl)cc1-c1nn(C)cc1NC(=O)c1cncc2c[nH]nc12 CHEMBL4788474 Ki 0.6 nM
Clc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)s1 CHEMBL3949285 IC50 0.61 nM
CN1CC[C@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@H]2C1 CHEMBL3891137 Ki 0.61 nM
CC(C)Oc1ccc(CN(C)C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)cc1 CHEMBL3982069 Ki 0.61 nM
O=C(Nc1cn(CC(=O)N2CCN(CCCO)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3940929 Ki 0.61 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCC(Oc3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3896005 Ki 0.61 nM
N=C(N)CCCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3924451 Ki 0.61 nM
CN(CC(F)(F)c1ccccc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3945615 Ki 0.62 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCN(CC3CC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3984406 Ki 0.62 nM
O=C(Nc1cn(CCNCc2ccccn2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3965157 Ki 0.62 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.627 nM
CN(CC1(C)COC1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3944446 Ki 0.63 nM
CN(Cc1ccc(Cl)cc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3905167 Ki 0.63 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@@H]2C[C@H]3CC[C@@H](C2)N3)c2nc(N)ncc2c1 CHEMBL5075673 pIC50 0.631 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@@H](C)CO)c2nc(NCCCCCN(C)C)ncc2c1 CHEMBL5075556 pIC50 0.631 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCN(Cc2ccc(Cl)cn2)[C@@H](C)C1 CHEMBL5423944 IC50 0.637 nM
CN(C)C1CCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3937927 Ki 0.64 nM
CN(C)C(=O)CCCN1CCC(n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3971636 Ki 0.64 nM
CC(C)CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3900031 Ki 0.64 nM
[C-]#[N+][C@H]1C[C@@H](C(C)(C)O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647911 IC50 0.65 nM
CN(C)[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccccc3)n2)[C@@H](C#N)C1 CHEMBL3703100 IC50 0.65 nM
CN([C@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1)C1(C)COC1 CHEMBL3647805 IC50 0.65 nM
N#C[C@H]1C[C@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@@H](O)C(F)(F)F)cc2)n1 CHEMBL3703056 IC50 0.65 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CC3CNCC3C2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3936541 Ki 0.65 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CC4CCC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3952029 Ki 0.65 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CC4CCCCC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3971672 Ki 0.65 nM
N#CCCNC1CCC(=CCn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3929567 Ki 0.65 nM
CN1CN([C@H]2CC[C@H](CNS(C)(=O)=O)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3919463 IC50 0.65 nM
N#Cc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)s1 CHEMBL3937067 IC50 0.66 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CNC[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3931278 Ki 0.66 nM
CN1C[C@H]2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@H]2C1 CHEMBL4111284 Ki 0.66 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CC4CCC(F)(F)CC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3957547 Ki 0.66 nM
CN1C[C@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@@]2(c2ccccc2)C1 CHEMBL3905567 Ki 0.66 nM
CN(C)C1CN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3950178 Ki 0.66 nM
CCNC1CCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3984741 Ki 0.66 nM
O=C(Nc1cn(CC(=O)N2CCC[C@H]2C(O)CO)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3924226 Ki 0.66 nM
CC1CN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CCN1C CHEMBL3933501 Ki 0.66 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@H](O)C(F)F)nc2)n1 CHEMBL3699538 IC50 0.67 nM
CN(C)CC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3896994 Ki 0.67 nM
CN(CCC1CCCCC1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3965438 Ki 0.67 nM
CC(C)CN1CCC(n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3969253 Ki 0.67 nM
COc1cc2ccccc2cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12 CHEMBL4742382 Ki 0.67 nM
COCCN(C)C1CCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3914377 Ki 0.68 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(CCCO)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3912800 Ki 0.68 nM
O=C1CCC(Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)O1 CHEMBL3910212 Ki 0.68 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL2103743 Ki 0.68 nM
CN1CC[C@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC[C@H]21 CHEMBL3920824 Ki 0.69 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(CCCN3CCNC3=O)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3912643 Ki 0.69 nM
COC(=O)C1CCN(CCN2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3985677 Ki 0.69 nM
CCOC(=O)C1CCN(CCN2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3918255 Ki 0.69 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(CO)cc4)cc23)CC[C@]1(C)N CHEMBL3671811 IC50 0.7 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4cccnc4)cc23)CC[C@]1(C)N CHEMBL3671804 IC50 0.7 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(OC(F)F)cc2)n1 CHEMBL3702924 IC50 0.7 nM
N#C[C@H]1C[C@@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3703070 IC50 0.7 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(C(=O)NC5CC5)cc4)cc23)CC[C@]1(C)N CHEMBL3671807 IC50 0.7 nM
N#C[C@H]1C[C@H](NC2COC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(CC(F)(F)F)cc2)n1 CHEMBL3703049 IC50 0.7 nM
COc1ccc(Cl)cc1-c1nc(C)sc1NC(=O)c1cnn2cccnc12 CHEMBL3667519 Ki 0.7 nM
CN[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3703019 IC50 0.7 nM
N#C[C@H]1C[C@@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(OC(F)(F)F)cc2)n1 CHEMBL3703035 IC50 0.7 nM
N#C[C@H]1CC(NC2CC2)CCC1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3702975 IC50 0.7 nM
COc1ccc(Cl)cc1-c1nn(CC(=O)N2CCCC2C)cc1NC(=O)c1cnn2cccnc12 CHEMBL3667522 Ki 0.7 nM
O=c1[nH]ccc(N[C@H]2CC[C@@H](NCC(F)F)CC2)c1-c1nc2ccccc2[nH]1 CHEMBL3781394 IC50 0.7 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)c3ccc(C#N)nc3)C4)n[nH]c2c1 CHEMBL3644629 IC50 0.7 nM
CC1(C)CN(c2ccc(C#N)cn2)CC[C@H]1Nc1c(C(N)=O)cnn2cc(N3CC[C@@H](O)C3=O)cc12 CHEMBL3667478 IC50 0.7 nM
CC[C@H]1CN(C(=O)OC(C)(C)C)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cc(C)no3)cc12 CHEMBL3672465 IC50 0.7 nM
Fc1cc(Cl)ccc1CN1CCC(c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3949040 IC50 0.7 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2ccc(OC(F)F)nc2)CC1 CHEMBL3952926 IC50 0.7 nM
COc1ncc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)cn1 CHEMBL3971268 IC50 0.7 nM
CN(C)C(=O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1 CHEMBL3904021 IC50 0.7 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(C4CC4)nc3)n2)CCN(C(=O)OCC(F)F)CC1 CHEMBL3891348 IC50 0.7 nM
N#CCC1(n2cc(C(N)=O)c(Nc3cncc(F)c3)n2)CCN(C(=O)OCC(F)(F)F)CC1 CHEMBL3891171 IC50 0.7 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(Cc2c(F)ccc(F)c2F)CC1 CHEMBL3909340 IC50 0.7 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ccco2)CC1 CHEMBL3972223 IC50 0.7 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2cccc3cc[nH]c23)CC1 CHEMBL3956546 IC50 0.7 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(S(=O)(=O)C(F)(F)F)CC1 CHEMBL3901595 IC50 0.7 nM
COc1cccc(S(=O)(=O)N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccccc4)n3)CC2)c1 CHEMBL3893139 IC50 0.7 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(NCC(F)F)CC1 CHEMBL3936267 IC50 0.7 nM
CCOC(=O)N1CCC(CN2C[C@@H]3CN(C(=O)Cn4cc(NC(=O)c5cnn6cccnc56)c(-c5cc(Cl)ccc5OC(F)F)n4)C[C@@H]3C2)CC1 CHEMBL3932644 Ki 0.7 nM
CN1CCC2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2C1 CHEMBL3912732 Ki 0.7 nM
CN(CC1CCC(=O)O1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3962087 Ki 0.7 nM
CC(C)N1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3940918 Ki 0.7 nM
N#CCC1(COC(=O)N2CC[C@@H](C#N)[C@H](n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)C2)CC1 CHEMBL3927605 IC50 0.7 nM
N#C[C@@H]1CCN(Cc2ccc(F)cn2)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3959023 IC50 0.7 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)nc2)n1 CHEMBL4113945 IC50 0.7 nM
Cc1ccccc1-c1cc2c(N[C@@H]3CC[C@](C)(N)C3(C)C)c(C(N)=O)cnn2c1 CHEMBL4068856 IC50 0.7 nM
CN(c1ncnc2[nH]ccc12)N1CCC[C@@H](C(=O)NCC(F)(F)F)C1 CHEMBL5175536 IC50 0.7 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CC4CC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3984720 Ki 0.71 nM
CN1CC2CN(C(=O)Cn3cc(NC(=O)c4c(N)nn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2C1 CHEMBL3909568 Ki 0.71 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CC4CCN(C(=O)OCc5ccccc5)CC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3976307 Ki 0.71 nM
CN(C)CCOC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3979961 Ki 0.71 nM
Nc1nn2cccnc2c1C(=O)Nc1cn([C@H]2CCNC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3934335 Ki 0.71 nM
O=C(Nc1cn(CC(=O)N2CC3CCCNC3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3924255 Ki 0.71 nM
O=C(Nc1cn(Cc2cn(C3CCNCC3)nn2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3915071 Ki 0.71 nM
O=C(Nc1c[nH]nc1-c1cc(F)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL4798728 Ki 0.71 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCNCC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3903218 Ki 0.72 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CCCN4CCOCC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3981144 Ki 0.72 nM
CN(CCc1ccccn1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3897795 Ki 0.72 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCCNCC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3917854 Ki 0.72 nM
O=C(Nc1cn(CCNCc2ccncc2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3928249 Ki 0.72 nM
CC(C)(C)OC(=O)N1CC[C@@H](n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)[C@H](O)C1 CHEMBL4109552 Ki 0.72 nM
O=C(Nc1cn(CCNCc2cccnc2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3926601 Ki 0.72 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CCc4ccccc4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3901102 Ki 0.73 nM
CC(=O)NCCCN1CCC(n2cc(NC(=O)/C(C(=N)N)=C3\N=CC=CN3)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3927535 Ki 0.73 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCNCC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3907431 Ki 0.73 nM
CN(C)C(=O)[C@@H]1CCCN1CC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3890546 Ki 0.73 nM
CN1CC[C@@H]2[C@@H](CCN2C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3896393 Ki 0.74 nM
CN1CCC2CN(C(=O)Cn3cc(NC(=O)c4c(N)nn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CCC21 CHEMBL3892526 Ki 0.74 nM
COCCN(C)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3901746 Ki 0.74 nM
CS(=O)(=O)CCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3928370 Ki 0.74 nM
CN(C)[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(OC(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3703057 IC50 0.75 nM
C[C@]1(O)CC[C@H](n2cc(C(N)=O)c(Nc3ccc([C@](C)(O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647838 IC50 0.75 nM
CC1(C)CN([C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3647775 IC50 0.75 nM
N#C[C@H]1C[C@@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccccc2)n1 CHEMBL3702984 IC50 0.75 nM
O=C(Nc1cn(CC(=O)N2CCC(NCCc3ccc(O)cc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3952689 Ki 0.75 nM
CC1CN(C)CCN1C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3927656 Ki 0.75 nM
CN(C)C(=O)CNC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3900033 Ki 0.75 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CCCN4C(=O)Cc5ccccc54)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3980799 Ki 0.76 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(CCCC(=O)N3CCCCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3976050 Ki 0.76 nM
CN1CCC(n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3937878 Ki 0.76 nM
O=C(Nc1cn(CC(=O)N2C[C@@H]3CCN[C@@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3908233 Ki 0.76 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2cccc(OC)c2)C[C@@H]1F CHEMBL4747742 IC50 0.769 nM
O=C(Nc1cn(CC(=O)N2CC[C@H]3CN(CC4CCOCC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3898231 Ki 0.77 nM
CCOC(=O)CNC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3970958 Ki 0.77 nM
CCCCOc1ccc(CN(C)C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)cc1 CHEMBL3975956 Ki 0.78 nM
CN(C)C1CCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3959924 Ki 0.78 nM
CCOC(=O)CCCN1CCC(n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3898055 Ki 0.78 nM
CN(C)CC#Cc1nc(-c2cc(Cl)ccc2OC(F)F)c(NC(=O)c2cnn3cccnc23)s1 CHEMBL3970487 Ki 0.78 nM
CCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3955984 Ki 0.78 nM
N=C(N)CCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3909090 Ki 0.78 nM
Brc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)s1 CHEMBL3967749 IC50 0.79 nM
CN1C[C@@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@@H]2C1 CHEMBL3974166 Ki 0.79 nM
CN(Cc1ccccc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3959615 Ki 0.79 nM
CN(C)C(=O)CN1CCC(CN2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3982869 Ki 0.79 nM
CCc1cc(O)c(F)cc1-c1cc(NC2CCN(C(C)=O)CC2)c2nc(N)ncc2c1 CHEMBL5084542 pIC50 0.7943 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(C#N)nc2)[C@H](C)C1 CHEMBL5405043 IC50 0.799 nM
Cn1nc(-c2cnc3[nH]cc(C(=O)N[C@@H](C(=O)N4CC(C#N)C4)C4CC4)c3n2)c2ccc(Cl)cc21 CHEMBL2376154 IC50 0.8 nM
C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](NCC(F)(F)F)CC1 CHEMBL2386629 Ki 0.8 nM
C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1C1CCCCC1 CHEMBL2386640 Ki 0.8 nM
COCC(C)(C)N[C@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3647795 IC50 0.8 nM
C[C@H](N[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1)C1CC1 CHEMBL3647758 IC50 0.8 nM
[C-]#[N+][C@H]1C[C@@H](CF)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccnc(F)c2)n1 CHEMBL3647912 IC50 0.8 nM
CC(C)(C)N[C@H]1CCC(n2cc(C(N)=O)c(Nc3ccccc3)n2)[C@@H](C#N)C1 CHEMBL3647788 IC50 0.8 nM
C[C@@H](N[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1)C1CC1 CHEMBL3647756 IC50 0.8 nM
CC(C)(C)OC(=O)NC1CC[C@H](C#N)C(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1 CHEMBL3699492 IC50 0.8 nM
CN[C@@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)[C@@H](C#N)C1 CHEMBL3640018 IC50 0.8 nM
CC(C)(C)OC(=O)NC1CC[C@@H](C#N)C(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1 CHEMBL3699493 IC50 0.8 nM
COC(=O)C1CCc2[nH]c(-c3c(N[C@H]4CC[C@@H](N)CC4)cc[nH]c3=O)nc2C1 CHEMBL3780467 IC50 0.8 nM
COCCN[C@H]1CC[C@@H](Nc2cc[nH]c(=O)c2-c2nc3ccccc3[nH]2)CC1 CHEMBL3780230 IC50 0.8 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(Cc3ccccc3)CC4)n[nH]c2c1 CHEMBL3644627 IC50 0.8 nM
CC(=O)N1CCN(c2cc3c(N[C@@H]4C[C@@H]5CN(S(C)(=O)=O)C[C@@H]5[C@H]4C)c(C(N)=O)cnn3c2)C1=O CHEMBL3667468 IC50 0.8 nM
CC[C@H]1CN(c2ccc(C#N)cn2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccc(=O)n(C)c3)cc12 CHEMBL3672451 IC50 0.8 nM
CC[C@H]1CN(c2ncc(C#N)s2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)cc12 CHEMBL3672472 IC50 0.8 nM
CC[C@H]1CN(c2ncc(C#N)s2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC(C)C)c3)cc12 CHEMBL3672473 IC50 0.8 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1 CHEMBL3948386 IC50 0.8 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(C)(C)O)nc3)n2)CC1 CHEMBL3951123 IC50 0.8 nM
Cn1cc(-c2cncc(Nc3nn(C4(CC#N)CCN(C(=O)OCC(F)(F)F)CC4)cc3C(N)=O)c2)cn1 CHEMBL3945825 IC50 0.8 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(N4CCOCC4)nc3)n2)CC1 CHEMBL3912678 IC50 0.8 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)nc3)n2)CC1 CHEMBL3940671 IC50 0.8 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(Cc2c(F)cccc2F)CC1 CHEMBL3954853 IC50 0.8 nM
CC(OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1)C(F)(F)F CHEMBL3911136 IC50 0.8 nM
COc1ccc(S(=O)(=O)N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccccc4)n3)CC2)cc1 CHEMBL3978603 IC50 0.8 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(Nc2ccc(F)c(F)c2)CC1 CHEMBL3946178 IC50 0.8 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(NCC2CCCCC2)CC1 CHEMBL3915696 IC50 0.8 nM
COc1ccc(CCN(C)C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)cc1 CHEMBL3966370 Ki 0.8 nM
CN1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3952022 Ki 0.8 nM
N#C[C@@H]1CS(=O)(=O)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL4111885 IC50 0.8 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(F)nc2)n1 CHEMBL4110738 IC50 0.8 nM
Cn1cc(Nc2ncc(Cl)c(NC3CCC4(CC3)CCN(C(=O)CC#N)C4)n2)cn1 CHEMBL3944322 IC50 0.8 nM
C[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3ccc4c(cnn4C)c3)nc12 CHEMBL3951604 IC50 0.8 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4ccccc4[nH]3)n[nH]c2c1 CHEMBL4103980 IC50 0.8 nM
Cc1ccc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)cc1 CHEMBL4060536 IC50 0.8 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccccc4Cl)cc23)CC[C@]1(C)N CHEMBL4105015 IC50 0.8 nM
CC[C@@H]1CN(C(=O)NCC(F)(F)F)C[C@@H]1c1cnc2cnc3[nH]ccc3n12 CHEMBL3622821 IC50 0.8 nM
CNC(=O)CCCN1CCC(n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3900499 Ki 0.81 nM
CN1C[C@H]2C[C@@H]1CN2C(=O)Cn1cc(NC(=O)c2c(N)nn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL4111927 Ki 0.81 nM
CC(C)CN1C[C@@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@@H]2C1 CHEMBL3903720 Ki 0.82 nM
C[C@@H]1CN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C[C@H](C)N1 CHEMBL3934286 Ki 0.83 nM
CCOC(=O)C1(C)CCN(CCN2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3950272 Ki 0.83 nM
O=C(Nc1cn(CCNCc2ncco2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3935396 Ki 0.83 nM
O=C(Nc1cn(CCN[C@@H]2CCOC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL4110635 Ki 0.83 nM
CCN1C[C@@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@@H]2C1 CHEMBL3899762 Ki 0.84 nM
CN(C)C(=O)N1CCC(CN2C[C@@H]3CN(C(=O)Cn4cc(NC(=O)c5cnn6cccnc56)c(-c5cc(Cl)ccc5OC(F)F)n4)C[C@@H]3C2)CC1 CHEMBL3968299 Ki 0.84 nM
CN(CCOc1ccccc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3950892 Ki 0.84 nM
COC(=O)C1(C)CCN(CCN2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3895560 Ki 0.84 nM
CCNC(=O)O[C@@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647872 IC50 0.85 nM
C=C[C@@]1(O)CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3647846 IC50 0.85 nM
N#C[C@@H]1C[C@@H](NC2COC2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3639466 IC50 0.85 nM
CC1(N[C@H]2CCC(n3cc(C(N)=O)c(Nc4ccc(Cl)cc4)n3)[C@@H](C#N)C2)CCOCC1 CHEMBL3647808 IC50 0.85 nM
N#C[C@H]1CC([N+]2(CC3CC3)CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL4111738 IC50 0.85 nM
N#C[C@H]1CCC2(C[C@@H]1n1cc(C(N)=O)c(Nc3ccccc3)n1)OCCO2 CHEMBL3650681 IC50 0.85 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CCCOC(=O)C4CCC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3951947 Ki 0.85 nM
CN1CN([C@H]2CC[C@H](COCCC#N)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3896113 IC50 0.85 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)ccc1SC(F)F)c1cnn2cccnc12 CHEMBL4778284 Ki 0.85 nM
O=C(Nc1cn(CC(=O)N2CCC(N3CCCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3892717 Ki 0.86 nM
CN(CCc1ccccc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3906556 Ki 0.86 nM
CN(C)CCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3939335 Ki 0.86 nM
O=C(Nc1cn(CC(=O)N2CCN3CCCCC3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3913483 Ki 0.87 nM
O=C(Nc1cn(C/C=C/CN2CCOCC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3920894 Ki 0.87 nM
COCCCN1C[C@@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@@H]2C1 CHEMBL3916637 Ki 0.88 nM
O=C(Nc1cn(CC(=O)N2CCC(NCCc3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3951483 Ki 0.88 nM
CN1CCCC(n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3894688 Ki 0.88 nM
O=C1NCN([C@H]2CC[C@H](CNCC(F)(F)Br)CC2)c2c1cnc1[nH]ccc21 CHEMBL3934061 IC50 0.88 nM
CS(=O)(=O)NC[C@H]1CC[C@H](N2CN(CC(F)(F)F)C(=O)c3cnc4[nH]ccc4c32)CC1 CHEMBL3967370 IC50 0.88 nM
CN(C)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3925466 Ki 0.89 nM
CN(C)C1CCN(C(=O)C2CCN(c3nc(-c4cc(Cl)ccc4OC(F)F)c(NC(=O)c4cnn5cccnc45)s3)CC2)CC1 CHEMBL3906961 Ki 0.89 nM
COCCNCCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3957231 Ki 0.89 nM
NC1CCC(=CCn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3922122 Ki 0.89 nM
COc1ccc(Cl)cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12 CHEMBL4800012 Ki 0.89 nM
CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](n2cnc3cnc4[nH]ccc4c32)C1 CHEMBL2152296 Ki 0.9 nM
Cc1nc2cnc3[nH]ccc3c2n1C1CCN(CCC#N)CC1 CHEMBL2159143 Ki 0.9 nM
C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@@H](C#N)CC1 CHEMBL2386634 Ki 0.9 nM
N#C[C@H]1C[C@H](OCC2CC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@H](O)C(F)(F)F)cc2)n1 CHEMBL3702965 IC50 0.9 nM
N#C[C@H]1C[C@H](N2C[C@@H]3[C@@H](CO)[C@@H]3C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3702995 IC50 0.9 nM
N#C[C@H]1C[C@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3703097 IC50 0.9 nM
CC1(N[C@H]2CCC(n3cc(C(N)=O)c(Nc4ccc(Cl)cc4)n3)[C@@H](C#N)C2)CC1 CHEMBL3647778 IC50 0.9 nM
C[C@H](NC1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)cc3)n2)[C@@H](C#N)C1)C1CC1 CHEMBL3647764 IC50 0.9 nM
CS(=O)(=O)N[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3647914 IC50 0.9 nM
N#C[C@H]1CC(NCC(F)F)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)F)cc2)n1 CHEMBL3703089 IC50 0.9 nM
COCCN[C@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3647809 IC50 0.9 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)NCc3ccccn3)cc2)n1 CHEMBL3702906 IC50 0.9 nM
N#C[C@H]1C[C@@H](NC2CC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3647715 IC50 0.9 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)N3CCC4(CC3)OCCO4)cc2)n1 CHEMBL3702913 IC50 0.9 nM
CC1(C)CN([C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccccc4)n3)[C@@H](C#N)C2)C1 CHEMBL3647716 IC50 0.9 nM
CS(=O)(=O)N[C@@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)[C@H](C#N)C1 CHEMBL3650677 IC50 0.9 nM
N[C@H]1CC[C@@H](Nc2cc[nH]c(=O)c2-c2nc3c([nH]2)CCCC3)CC1 CHEMBL3780299 IC50 0.9 nM
COc1ncc(-c2cc3c(N[C@@H]4CN(C(=O)C5(C#N)CC5)C[C@@H]4CF)c(C(N)=O)cnn3c2)cn1 CHEMBL3672463 IC50 0.9 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cncc(Cl)c3)n2)CC1 CHEMBL3936727 IC50 0.9 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2cccc(C#N)c2)CC1 CHEMBL3899546 IC50 0.9 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)OC2CCC2)CC1 CHEMBL3942553 IC50 0.9 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)OCC2CC2(F)F)CC1 CHEMBL3982019 IC50 0.9 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)OCC2(O)CC2)CC1 CHEMBL3985566 IC50 0.9 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(C(=O)OC2CCOC2)CC1 CHEMBL3954705 IC50 0.9 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(C(=O)CC2CCCO2)CC1 CHEMBL3930998 IC50 0.9 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CN(C(=O)Nc2ccc(C#N)cc2)C1 CHEMBL4113838 IC50 0.9 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(N2CCC3C=CC=CC32)CC1 CHEMBL3901464 IC50 0.9 nM
CC(F)(F)C(=O)N1CC[C@](CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)nc3)n2)[C@H](F)C1 CHEMBL4108087 IC50 0.9 nM
O=C(Nc1cn(CCN[C@H]2CCOC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3909091 Ki 0.9 nM
N#C[C@@H]1CCOC[C@H]1n1cc(C(N)=O)c(Nc2cncc(F)c2)n1 CHEMBL3928267 IC50 0.9 nM
CC(=O)N1CCC2(CCC(Nc3nc(Nc4cnn(C)c4)ncc3Cl)CC2)CC1 CHEMBL3905686 IC50 0.9 nM
Cn1cc(Nc2ncc(Cl)c(NC3CCC4(CC3)CCN(C(=O)C(F)(F)F)CC4)n2)cn1 CHEMBL3953702 IC50 0.9 nM
CN(CC(F)(F)F)C[C@H]1CC[C@H](N2CN(CC#N)C(=O)c3cnc4[nH]ccc4c32)CC1 CHEMBL3968872 IC50 0.9 nM
CCc1cc(O)ccc1-c1ccc2c(-c3ncc[nH]3)n[nH]c2c1 CHEMBL4086057 IC50 0.9 nM
N#Cc1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)cc1C#N CHEMBL4064171 IC50 0.9 nM
Cc1cccc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)c1 CHEMBL4087655 IC50 0.9 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(Cl)cc4)cc23)CC[C@]1(C)N CHEMBL4062062 IC50 0.9 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(C#N)cc4)cc23)CC[C@]1(C)N CHEMBL4091582 IC50 0.9 nM
N#Cc1ccc(OC(F)F)c(-c2n[nH]cc2NC(=O)c2cnn3cccnc23)c1 CHEMBL4784721 Ki 0.9 nM
CN1CC[C@@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC[C@@H]21 CHEMBL4109979 Ki 0.91 nM
O=C(Nc1cn(CC(=O)N2CCC(NC3CCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3977209 Ki 0.91 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(CCCN3CCN(Cc4ccccc4)C3=O)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3903629 Ki 0.91 nM
CN1CCC2(CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C2)C1 CHEMBL3958363 Ki 0.91 nM
CCOC(=O)CCN(C)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3929711 Ki 0.91 nM
Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2C2CC2)n1 CHEMBL4756764 Ki 0.91 nM
O=C(Nc1cn(CC(=O)N2CCC(NCCc3ccc(Cl)cc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3892396 Ki 0.92 nM
CN1CC2(CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C2)C1 CHEMBL3921334 Ki 0.92 nM
N#CC[C@H]1CC[C@H](n2c(CNC(=O)CC3CC3)nc3cnc4[nH]ccc4c32)CC1 CHEMBL4437638 IC50 0.92 nM
CN(CCOc1ccc(Br)cc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3946998 Ki 0.93 nM
CN1CCN(C(=O)c2ccc(-c3nc(-c4cc(Cl)ccc4OC(F)F)c(NC(=O)c4cnn5cccnc45)s3)cc2)CC1 CHEMBL3891220 Ki 0.93 nM
O=C(Nc1cn([C@@H]2CCNC[C@H]2O)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL4106450 Ki 0.93 nM
CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1(C)C CHEMBL3942659 Ki 0.93 nM
CC(=O)SC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3905627 IC50 0.94 nM
CC(=O)N1CCC(CN2C[C@@H]3CN(C(=O)Cn4cc(NC(=O)c5cnn6cccnc56)c(-c5cc(Cl)ccc5OC(F)F)n4)C[C@@H]3C2)CC1 CHEMBL3956651 Ki 0.94 nM
CN1CC[C@H]2[C@H](CCN2C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL4107631 Ki 0.94 nM
N#C[C@H]1C[C@H](OC(=O)Nc2ccccc2)CCC1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3647868 IC50 0.95 nM
N#C[C@H]1C[C@@H](N2CC3(COC3)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3703087 IC50 0.95 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3702925 IC50 0.95 nM
CN(CCc1ccc(O)cc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3981440 Ki 0.95 nM
CN1[C@@H]2CC[C@H]1CN(C(=O)Cn1cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n1)C2 CHEMBL3950200 Ki 0.95 nM
O=C(Nc1cn(CC(=O)N2CCNCC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3980200 Ki 0.95 nM
COc1ccc(Cl)c(F)c1-c1n[nH]cc1NC(=O)c1cnn2cccnc12 CHEMBL4794915 Ki 0.95 nM
CN(C)CC1(O)CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3918506 Ki 0.97 nM
CN(CCOc1ccc(Cl)cc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3913096 Ki 0.97 nM
Clc1ncc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)s1 CHEMBL3912553 IC50 0.98 nM
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3ncnc4[nH]ccc34)cn2)C1 CHEMBL2105759 IC50 0.99 nM
IC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3934116 IC50 0.99 nM
CC(C)(O)CCN1C[C@@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@@H]2C1 CHEMBL3929116 Ki 0.99 nM
Cc1ccn2ncc(C(=O)Nc3c[nH]nc3-c3cc(Cl)ccc3OC(F)F)c2n1 CHEMBL4760406 Ki 0.99 nM
Cc1cnc(Nc2cnn(C)c2)nc1-c1cnn([C@H](CC#N)C2CCCC2)c1 CHEMBL5395308 IC50 0.99 nM
C[C@@H](NC(=O)c1c[nH]c2ncc(-c3cn(C)c4cc(Cl)ccc34)nc12)C(=O)N1CC(C#N)C1 CHEMBL2376143 IC50 1.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)c(CO)c2)n1 CHEMBL3699518 IC50 1.0 nM
CC1(CN[C@@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(C(F)(F)F)cc4)n3)[C@@H](C#N)C2)COC1 CHEMBL3702996 IC50 1.0 nM
N#C[C@@H]1C[C@H](OCC2CC2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc([C@H](O)C(F)(F)F)cc2)n1 CHEMBL3702964 IC50 1.0 nM
CC[N+]1(C2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(Cl)cc4)n3)[C@@H](C#N)C2)CCC1 CHEMBL4115335 IC50 1.0 nM
N#C[C@H]1C[C@H](O)CCC1n1cc(C(N)=O)c(Nc2ccnc(F)c2)n1 CHEMBL3699501 IC50 1.0 nM
CC1(C#N)CCCC1Nc1c(C(N)=O)cnn2cc(-c3ccccc3)cc12 CHEMBL3671790 IC50 1.0 nM
N#C[C@H]1C[C@H](NCC2(O)CC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3703014 IC50 1.0 nM
N#C[C@H]1C[C@@H](N2CC(F)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3703081 IC50 1.0 nM
CC1(C)CN([C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccnc(F)c4)n3)[C@@H](C#N)C2)C1 CHEMBL3703099 IC50 1.0 nM
N#C[C@@H]1CCCC[C@H]1n1cc(C(N)=O)c(Nc2ccc3c(c2)CN(CC(F)(F)F)C3=O)n1 CHEMBL3699522 IC50 1.0 nM
CN(c1ncnc2[nH]ccc12)[C@H]1C[C@@H](NS(=O)(=O)N2CCC(c3cc[nH]n3)CC2)C1 CHEMBL3655103 IC50 1.0 nM
N#Cc1ccc(Nc2nn([C@H]3CC[C@H](NCC(F)F)C[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3703084 IC50 1.0 nM
CN(CC(F)(F)F)[C@H]1CCC(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)[C@@H](C#N)C1 CHEMBL3647806 IC50 1.0 nM
N#C[C@H]1CC(N2CCC[C@H]2CF)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647733 IC50 1.0 nM
CN(C)[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(OC(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3703066 IC50 1.0 nM
COCC(C)N[C@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3647810 IC50 1.0 nM
N#C[C@H]1C[C@@H](N2CC3(CCC3)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccccc2)n1 CHEMBL3703101 IC50 1.0 nM
CC(C)(CF)c1ccc(Nc2nn([C@H]3CC[C@@H](O)C[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3702945 IC50 1.0 nM
CC1(C)CN([C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(Cl)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3647721 IC50 1.0 nM
CC(C)(CF)c1ccc(Nc2nn([C@H]3CC[C@H](O)C[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3647865 IC50 1.0 nM
N#C[C@H]1C[C@H](N2CC3(CCC3)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccnc(F)c2)n1 CHEMBL3647720 IC50 1.0 nM
N#C[C@H]1C[C@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)c(F)c2)n1 CHEMBL3702940 IC50 1.0 nM
CN([C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1)S(C)(=O)=O CHEMBL3647917 IC50 1.0 nM
CC1(c2ccc(Nc3nn([C@H]4CC[C@@H](O)C[C@@H]4C#N)cc3C(N)=O)cc2)COC1 CHEMBL3702954 IC50 1.0 nM
CC(N[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1)C1CC1 CHEMBL3647750 IC50 1.0 nM
CC(C)(CO)N[C@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3647783 IC50 1.0 nM
CC(C)(c1ccc(Nc2nn([C@H]3CC[C@@](C)(O)C[C@@H]3C#N)cc2C(N)=O)cc1)C(O)C(F)(F)F CHEMBL3647834 IC50 1.0 nM
N#C[C@H]1C[C@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3702942 IC50 1.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(OC(F)(F)F)cc2)n1 CHEMBL3702927 IC50 1.0 nM
CN([C@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1)C(C)(C)C1CC1 CHEMBL3647802 IC50 1.0 nM
C[C@H](N[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1)C1CC1 CHEMBL3703086 IC50 1.0 nM
C[C@](O)(c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cn1)C(F)F CHEMBL3699540 IC50 1.0 nM
N#C[C@H]1C[C@@H](N2CC(O)(C(F)(F)F)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3647773 IC50 1.0 nM
Cc1cccc(C)c1NS(=O)(=O)c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3702909 IC50 1.0 nM
CC1(c2ccc(Nc3nn([C@H]4CC[C@H](O)C[C@@H]4C#N)cc3C(N)=O)cc2)COC1 CHEMBL3647863 IC50 1.0 nM
N#C[C@@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3650680 IC50 1.0 nM
CC1CN([C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3703088 IC50 1.0 nM
N#C[C@H]1C[C@@H](N)CCC1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3647813 IC50 1.0 nM
CN[C@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)[C@@H](C#N)C1 CHEMBL3702971 IC50 1.0 nM
CC(C)(O)C1CC(CN[C@H]2CC[C@@H](n3cc(C(N)=O)c(Nc4ccc(C(F)(F)F)cc4)n3)[C@H](C#N)C2)C1 CHEMBL3647816 IC50 1.0 nM
CNC(=O)O[C@@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647871 IC50 1.0 nM
CN(C)S(=O)(=O)CCNC1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647730 IC50 1.0 nM
N#C[C@H]1CC(N(C2CC2)C2CC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647754 IC50 1.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)NCc3ccc(Cl)cc3)cc2)n1 CHEMBL3702911 IC50 1.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Br)cc2)n1 CHEMBL3699527 IC50 1.0 nM
CC(C)(C(=O)O)c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3699554 IC50 1.0 nM
N#C[C@H]1CC(N2CC[C@H](F)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647734 IC50 1.0 nM
C[C@H](N[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(OC(F)(F)F)cc3)n2)[C@@H](C#N)C1)C1CC1 CHEMBL3703062 IC50 1.0 nM
C[C@@]1(O)CC[C@H](n2cc(C(N)=O)c(Nc3ccc([C@](C)(O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647839 IC50 1.0 nM
CN(C)[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)[C@@H](C#N)C1 CHEMBL3703065 IC50 1.0 nM
N#C[C@H]1C[C@](O)(C2CC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647842 IC50 1.0 nM
CC1CN([C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccccc4)n3)[C@@H](C#N)C2)C1 CHEMBL3647718 IC50 1.0 nM
CC(C)(C)N[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3702985 IC50 1.0 nM
C[N+]1(C2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(Cl)cc4)n3)[C@@H](C#N)C2)CCC1 CHEMBL4112874 IC50 1.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@@H](O)C(F)F)nc2)n1 CHEMBL3699539 IC50 1.0 nM
CC1(N[C@H]2CCC(n3cc(C(N)=O)c(Nc4ccc(Cl)cc4)n3)[C@@H](C#N)C2)COC1 CHEMBL3647780 IC50 1.0 nM
N#C[C@@H]1C[C@H](OCC2CC2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc([C@@H](O)C(F)(F)F)cc2)n1 CHEMBL3702966 IC50 1.0 nM
N#C[C@H]1C[C@@H](N2CC(O)(C(F)(F)F)C2)CCC1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647786 IC50 1.0 nM
N#C[C@H]1C[C@@H](N2CCC23COC3)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647723 IC50 1.0 nM
N#Cc1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3699506 IC50 1.0 nM
CC1(C)C[N+](C)(C2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(Cl)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL4112271 IC50 1.0 nM
N#C[C@H]1C[C@@H](NCC(F)(F)F)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccnc(F)c2)n1 CHEMBL3703079 IC50 1.0 nM
N#C[C@H]1CC(N2CCC[C@@H]2CF)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647732 IC50 1.0 nM
C[C@]1(O)CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3647840 IC50 1.0 nM
CC(C)(N[C@H]1CCC(n2cc(C(N)=O)c(Nc3ccccc3)n2)[C@@H](C#N)C1)C1CC1 CHEMBL3647787 IC50 1.0 nM
C[C@@]1(O)CC[C@H](n2cc(C(N)=O)c(Nc3ccc([C@@](C)(O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647841 IC50 1.0 nM
N#C[C@H]1C[C@H](N2CC3(COC3)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3703091 IC50 1.0 nM
COCCN[C@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3702981 IC50 1.0 nM
CN(CC1(C)COC1)[C@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3647792 IC50 1.0 nM
CC1(C)CCN1[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647769 IC50 1.0 nM
COc1ccc(C#N)cc1-c1nn(CC2(O)CCCC2)cc1NC(=O)c1cnn2cccnc12 CHEMBL3667524 Ki 1.0 nM
CC[C@@H]1CN(S(C)(=O)=O)CC[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CCC#N)c3)cc12 CHEMBL3667481 IC50 1.0 nM
CC[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccc(C)nc3)cc12 CHEMBL3672459 IC50 1.0 nM
Brc1ncc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)s1 CHEMBL3931093 IC50 1.0 nM
O[C@@H]1CCN(C[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)C1 CHEMBL4113620 IC50 1.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1 CHEMBL3955591 IC50 1.0 nM
C[C@H]1CN(C(=O)OC(C)(C)C)CC[C@]1(CC#N)n1cc(C(N)=O)c(Nc2ccccc2)n1 CHEMBL3891937 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2cncc(C(F)(F)F)c2)CC1 CHEMBL3896471 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2ccc(C(O)C(F)(F)F)cc2)CC1 CHEMBL3905818 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2cccc(F)c2)CC1 CHEMBL3977394 IC50 1.0 nM
Cc1ccnc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)c1 CHEMBL3923710 IC50 1.0 nM
Cc1cncc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)c1 CHEMBL3920825 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2cc(C(F)(F)F)ccn2)CC1 CHEMBL3924811 IC50 1.0 nM
Cc1cc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)cnc1F CHEMBL3890129 IC50 1.0 nM
CC(C)(C)OC(=O)N1CC[C@](CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)[C@@H](F)C1 CHEMBL3894383 IC50 1.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)c(F)c3)n2)CC1 CHEMBL3930265 IC50 1.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cc(Cl)nc(Cl)c3)n2)CC1 CHEMBL3902783 IC50 1.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cncc(F)c3)n2)CC1 CHEMBL3908774 IC50 1.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cccc(Br)c3)n2)CC1 CHEMBL3951216 IC50 1.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cc(F)ncn3)n2)CC1 CHEMBL3965345 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(CC2CCCCC2)CC1 CHEMBL3973996 IC50 1.0 nM
Cc1ncc(CN2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccnc(F)c4)n3)CC2)s1 CHEMBL3892219 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ccon2)CC1 CHEMBL3960707 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(Cc2cc3ccccc3[nH]2)CC1 CHEMBL3952853 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(Cc2cnccn2)CC1 CHEMBL3894262 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(Cc2ccco2)CC1 CHEMBL3899688 IC50 1.0 nM
COc1ccc(CN2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccnc(F)c4)n3)CC2)cc1 CHEMBL3889517 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2cccc(=O)[nH]2)CC1 CHEMBL3975786 IC50 1.0 nM
COC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(C)(=O)=O)cc3)n2)CC1 CHEMBL3986584 IC50 1.0 nM
COCC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1 CHEMBL3932521 IC50 1.0 nM
CC1(COC(=O)N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)CC1 CHEMBL3962314 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3cncc(F)c3)n2)CCN(C(=O)OCC(F)F)CC1 CHEMBL3983335 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)OCC2CC2)CC1 CHEMBL3931158 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)OC2CCCC2)CC1 CHEMBL3961164 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)OC2CCOC2)CC1 CHEMBL3962407 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)OC2CCOC2)CC1 CHEMBL3911044 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)C2CC2)CC1 CHEMBL3907706 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(C(=O)CC2CC2)CC1 CHEMBL3986274 IC50 1.0 nM
CC(C)(C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1)C(F)(F)F CHEMBL3908935 IC50 1.0 nM
C[C@@H](O)CC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1 CHEMBL4109620 IC50 1.0 nM
CCS(=O)(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1 CHEMBL3900415 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(Nc2ccc(F)c(F)c2)CC1 CHEMBL3933473 IC50 1.0 nM
N#CCC1(C2C=C(C(N)=O)C(Nc3ccnc(F)c3)=N2)CCC(NC2CCOCC2)CC1 CHEMBL3890238 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(Nc2cccc(Cl)c2)CC1 CHEMBL3932767 IC50 1.0 nM
CN(CCS(C)(=O)=O)C1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1 CHEMBL3922614 IC50 1.0 nM
COC1CN(C2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)C1 CHEMBL3931541 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(NCC(F)(F)F)CC1 CHEMBL3923655 IC50 1.0 nM
N#CC[C@]1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CC[C@@H](N)CC1 CHEMBL3922061 IC50 1.0 nM
C[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@]1(CC#N)n1cc(C(N)=O)c(Nc2ccccc2)n1 CHEMBL4109703 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)O[C@H]2CCOC2)CC1 CHEMBL3912531 IC50 1.0 nM
O=C(Nc1cn(CC(=O)N2CCCN(CCO)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3941450 Ki 1.0 nM
CC(C)(C#N)COC(=O)N1CC[C@@H](C#N)[C@H](n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1 CHEMBL3917864 IC50 1.0 nM
N#C[C@@H]1CCN(C(=O)OCC(F)(F)CO)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3900020 IC50 1.0 nM
N#C[C@@H]1CCN(C(=O)OCCC2CC2)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3908048 IC50 1.0 nM
Cc1c(CN2CC[C@@H](C#N)[C@H](n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)C2)cnn1C CHEMBL3889987 IC50 1.0 nM
N#C[C@@H]1CCN(Cc2cccnc2F)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3947974 IC50 1.0 nM
Cc1ncc(CN2CC[C@@H](C#N)[C@H](n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)C2)s1 CHEMBL3974023 IC50 1.0 nM
N#C[C@@H]1CS(=O)(=O)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL4109366 IC50 1.0 nM
N#C[C@H]1CS(=O)(=O)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3932038 IC50 1.0 nM
Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(C(=O)CC#N)CC4C3)n2)cn1 CHEMBL3977718 IC50 1.0 nM
Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(S(C)(=O)=O)CC4C3)n2)cn1 CHEMBL3917073 IC50 1.0 nM
Cc1cnc(Nc2cnn(C)c2)nc1NC1CC2CN(c3ccc(C#N)cn3)CC2C1 CHEMBL3963780 IC50 1.0 nM
COc1cccc(-c2cn3ncc(C(N)=O)c(N[C@@H]4CN(C(=O)C5(C#N)CC5)C[C@@H]4C)c3n2)n1 CHEMBL3922507 IC50 1.0 nM
COc1cccc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)c1 CHEMBL4076794 IC50 1.0 nM
Cc1[nH]nc2[nH]c(=O)cc([C@H]3C[C@H]4C[C@@H]3C[C@@H]4CC#N)c12 CHEMBL4643061 IC50 1.0 nM
CCc1cc(O)c(F)cc1-c1cc(NC(CO)CO)c2nc(N)ncc2c1 CHEMBL5085176 pIC50 1.0 nM
Cc1[nH]nc2[nH]c(=O)cc(C3C[C@H]4C[C@@H]3C[C@@H]4CC#N)c12 CHEMBL5203044 IC50 1.0 nM
Cc1cnc(Nc2ccc(N3CCC(N4CCOCC4)CC3)cc2)nc1-c1ccc(C(=O)NCC#N)cc1 CHEMBL5175300 IC50 1.0 nM
N#CCNC(=O)c1ccc(-c2nc(Nc3ccc(N4CCC(N5CCOCC5)CC4)cc3)ncc2Cl)cc1 CHEMBL5189266 IC50 1.0 nM
COC[C@H](C)OC(=O)Cc1ccc(Nc2cc(Nc3ccccc3OC)c(C(N)=O)cn2)nc1 CHEMBL5412967 IC50 1.0 nM
CN1CCC2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CCC21 CHEMBL3981242 Ki 1.01 nM
O=C(Nc1sc(N2CCN(CC3CC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3959420 Ki 1.01 nM
CN1CC2(CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)C1 CHEMBL3957787 Ki 1.01 nM
Cc1ccc(OCCN(C)C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)cc1 CHEMBL3918941 Ki 1.04 nM
CCN1CC2CN(C(=O)Cn3cc(NC(=O)c4c(N)nn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2C1 CHEMBL3960474 Ki 1.05 nM
CN(C)C[C@H]1CCCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL4115152 Ki 1.06 nM
COC(=O)CNCCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3985077 Ki 1.06 nM
CNC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3966860 Ki 1.07 nM
CN(Cc1ccc(F)c(Br)c1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3902522 Ki 1.07 nM
O=C(Nc1cn(CC(=O)N2CC3(CCNCC3)C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3942739 Ki 1.07 nM
CCOC(=O)CN1CCC(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3932031 Ki 1.07 nM
O=C1CCC(CNCCn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)O1 CHEMBL3920178 Ki 1.07 nM
O=C(CCCN1CCC(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1)NC1CCOCC1 CHEMBL3984681 Ki 1.08 nM
CN1CCCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3944331 Ki 1.08 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CCCOC(=O)N4CCOCC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3944568 Ki 1.09 nM
CN(CCOc1ccccc1Cl)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3961979 Ki 1.09 nM
C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](NCC(F)F)CC1 CHEMBL2386630 Ki 1.1 nM
OCc1nc2cnc3[nH]ccc3c2n1C1CCCCC1 CHEMBL2386637 Ki 1.1 nM
O=C(c1cnc2[nH]c(-c3n[nH]c4cc(-c5cc(F)c(O)cc5CC(F)(F)F)ccc34)nc2c1)c1cnc(N2CCCCC2)cn1 CHEMBL3644645 IC50 1.1 nM
CC[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cn(C)nc3C)cc12 CHEMBL3672458 IC50 1.1 nM
CO[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccc(F)cc3)cc12 CHEMBL3672467 IC50 1.1 nM
Brc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3927649 IC50 1.1 nM
O=C1SCCC1NC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3920091 IC50 1.1 nM
CN1C[C@@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5ccc(N)nc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@@H]2C1 CHEMBL3918497 Ki 1.1 nM
CN1C[C@@H]2[C@H](C1)[C@H](CO)N(C(=O)Cn1cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n1)[C@@H]2c1ccccc1 CHEMBL3942241 Ki 1.1 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CCOCc4ccc(Cl)cc4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3915326 Ki 1.1 nM
CN(Cc1ccc2ccccc2c1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3919674 Ki 1.1 nM
CN(CC(F)(F)F)C1CCN(C(=O)C2CCN(c3nc(-c4cc(Cl)ccc4OC(F)F)c(NC(=O)c4cnn5cccnc45)s3)CC2)CC1 CHEMBL3934458 Ki 1.1 nM
CN1CCC2(C1)CN(C(=O)Cn1cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n1)C2 CHEMBL3975592 Ki 1.1 nM
Cc1nn(C)c(C)c1-c1cn2ncc(C(N)=O)c(N[C@H]3CN(C(=O)C4(C#N)CC4)C[C@H]3C)c2n1 CHEMBL4106494 IC50 1.1 nM
CCCn1cc(-c2cn3ncc(C(N)=O)c(N[C@@H]4CN(C(=O)C5(C#N)CC5)C[C@@H]4C)c3n2)cn1 CHEMBL3942856 IC50 1.1 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(Cl)cn2)[C@H](C)C1 CHEMBL5408324 IC50 1.1 nM
CN(Cc1cccc(C(F)(F)F)c1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3914169 Ki 1.12 nM
CN(C)C(=O)[C@@H]1CCCN1C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3894039 Ki 1.12 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2cccc(Cl)c2)[C@@H](C)C1 CHEMBL4789693 IC50 1.12 nM
CN1CCC2(CC1)CN(C(=O)Cn1cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n1)C2 CHEMBL3968827 Ki 1.13 nM
CN[C@@H](C)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3954236 Ki 1.13 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CCCO)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3950713 Ki 1.14 nM
Cc1ccc(CN(C)C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)c(C)c1 CHEMBL3980794 Ki 1.14 nM
CCN[C@@H](C)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3949681 Ki 1.14 nM
CCOC(=O)CNCCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3958066 Ki 1.15 nM
CN(CCc1ccc(C(F)(F)F)cc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3970542 Ki 1.16 nM
O=C(Nc1cn(C2CCN(CCCC(=O)N3CCOCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3976064 Ki 1.16 nM
CN(C)C[C@@H]1CCCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3951860 Ki 1.17 nM
CN(C)C[C@@H]1CCCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3975201 Ki 1.17 nM
CN1CC2(C1)CN(C(=O)Cn1cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n1)C2 CHEMBL3969424 Ki 1.17 nM
CN1CCN(c2ccc(-c3nc(-c4cc(Cl)ccc4OC(F)F)c(NC(=O)c4cnn5cccnc45)s3)cc2)CC1 CHEMBL3966147 Ki 1.17 nM
CN(Cc1cccc(Oc2ccccc2)c1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3915871 Ki 1.19 nM
CS(=O)(=O)N1CCC(n2cnc3cnc4[nH]ccc4c32)CC1 CHEMBL2152398 Ki 1.2 nM
Cc1nc2cnc3[nH]ccc3c2n1[C@@H]1CCNC[C@H]1F CHEMBL2159202 Ki 1.2 nM
C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](NCC(F)(F)F)C1 CHEMBL2386632 Ki 1.2 nM
CCOC1CCCN(S(=O)(=O)CC2CCC(N(C)c3ncnc4[nH]ccc34)CC2)C1 CHEMBL3652277 IC50 1.2 nM
COc1ccc(-c2cc3c(N[C@@H]4CC[C@](C)(C(N)=O)C4(C)C)c(C(N)=O)cnn3c2)cn1 CHEMBL3671829 IC50 1.2 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(S(=O)(=O)c3ccc(F)cc3)C4)n[nH]c2c1 CHEMBL3644626 IC50 1.2 nM
C[C@@H]1[C@H]2CN(C(=O)CF)C[C@H]2C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnc(N)c(F)c3)cc12 CHEMBL3667473 IC50 1.2 nM
CC[C@H]1CN(C(=O)C2(C#N)CCC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccnc(Cl)c3)cc12 CHEMBL3672462 IC50 1.2 nM
Clc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3986618 IC50 1.2 nM
FC(F)(F)CNC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3978202 IC50 1.2 nM
COc1ccc(C(O)(CN[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)C(F)(F)F)cc1 CHEMBL3953381 IC50 1.2 nM
CN(CCc1ccc(Cl)cc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3905546 Ki 1.2 nM
Cc1cc(-c2cn3ncc(C(N)=O)c(N[C@@H]4CN(C(=O)C5(C#N)CC5)C[C@@H]4CF)c3n2)ccn1 CHEMBL3927910 IC50 1.2 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccccc4F)cc23)CC[C@]1(C)N CHEMBL4076191 IC50 1.2 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4cccc(F)c4)cc23)CC[C@]1(C)N CHEMBL4071806 IC50 1.2 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(F)cc4)cc23)CC[C@]1(C)N CHEMBL4077508 IC50 1.2 nM
CC(C)Oc1ccc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)cn1 CHEMBL4070136 IC50 1.2 nM
COc1cc2c(=O)n([C@@H]3CCCN(C(=O)CC#N)C3)c3c4cc[nH]c4ncc3c2cc1OC CHEMBL4290597 IC50 1.2 nM
N#CC[C@H]1CC[C@H](n2c(CC(=O)N[C@H]3CC[C@H](O)CC3)nc3cnc4[nH]ccc4c32)CC1 CHEMBL4582390 IC50 1.2 nM
COCCOc1cc(Nc2cc(NC(C)=O)ncc2-c2ccccn2)nc(S(C)(=O)=O)c1 CHEMBL5422022 IC50 1.2 nM
CN(Cc1ccc(Br)cc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3900819 Ki 1.21 nM
C[N+](C)(CCCc1ccccc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3953340 Ki 1.21 nM
CCCCN(C)C1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3919476 Ki 1.22 nM
O=C(Nc1cn(CC(=O)N2CC3(CCNC3)C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3952559 Ki 1.22 nM
CC(C)(C)OC(=O)N1CC[C@H](O)[C@@H](n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3905318 Ki 1.22 nM
O=C(Nc1cn(C2CCN(CCCN3CCS(=O)(=O)CC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3971137 Ki 1.23 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(Cc3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3903778 Ki 1.23 nM
CN(CC1(C)COC1)C1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3920538 Ki 1.24 nM
COC(=O)[C@@H](N)CCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3915304 Ki 1.24 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(CCOCc3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3920777 Ki 1.25 nM
O=C(O)CNC1CCN(CCn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3978749 Ki 1.25 nM
CCc1cc(O)c(F)cc1-c1cc(NCCO)c2nc(N)ncc2c1 CHEMBL5082928 pIC50 1.259 nM
CCc1cc(O)c(F)cc1-c1cc(NCCCO)c2nc(N)ncc2c1 CHEMBL5084340 pIC50 1.259 nM
CCc1cc(O)c(F)cc1-c1cc(NC[C@@H](C)O)c2nc(N)ncc2c1 CHEMBL5079248 pIC50 1.259 nM
CN(C)C1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3921926 Ki 1.26 nM
O=C(Nc1cn(CC(=O)N2CCC(NCCc3ccc(C(F)(F)F)cc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3957933 Ki 1.28 nM
CCCCN(CC(F)(F)F)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3897207 Ki 1.28 nM
CN(CCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1)CC1CCC(=O)O1 CHEMBL3962664 Ki 1.28 nM
CN1CCN(C/C=C/Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3948702 Ki 1.29 nM
Cc1nc2cnc3[nH]ccc3c2n1C1CCCCC1 CHEMBL2159198 Ki 1.3 nM
Cc1nc2cnc3[nH]ccc3c2n1C1CCN(Cc2ccccc2)CC1 CHEMBL2159142 Ki 1.3 nM
Cc1ccncc1-c1cc2c(N[C@@H]3CC[C@](C)(N)C3(C)C)c(C(N)=O)cnn2c1 CHEMBL3671805 IC50 1.3 nM
Cc1cccc(-c2cc3c(N[C@@H]4CCC[C@]4(C)F)c(C(N)=O)cnn3c2)c1 CHEMBL3666889 IC50 1.3 nM
N[C@H]1CC[C@@H](Nc2cc[nH]c(=O)c2-c2nc3c([nH]2)CCC(C(=O)O)C3)CC1 CHEMBL3779939 IC50 1.3 nM
C[C@@H]1[C@H]2CN(S(C)(=O)=O)C[C@H]2C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3nnn(C)n3)cc12 CHEMBL3667472 IC50 1.3 nM
CS(=O)(=O)C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3934580 IC50 1.3 nM
N#CCCN(CCC#N)C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3951107 IC50 1.3 nM
FC(F)(Br)CNC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3985243 IC50 1.3 nM
FC(F)(F)C(NC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1)C(F)(F)F CHEMBL3916457 IC50 1.3 nM
Fc1ccc(C2(NC[C@H]3CC[C@H](c4nnn5cnc6[nH]ccc6c45)CC3)COC2)cc1 CHEMBL3926516 IC50 1.3 nM
O=S(=O)(C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1)C(F)(F)F CHEMBL3968041 IC50 1.3 nM
CC(C)N1C[C@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@H]2C1 CHEMBL3895921 Ki 1.3 nM
Cc1noc(C)c1-c1cn2ncc(C(N)=O)c(N[C@@H]3CN(C(=O)C4(C#N)CC4)C[C@@H]3CF)c2n1 CHEMBL3967441 IC50 1.3 nM
CCc1cc(O)ccc1-c1ccc2c(-c3nc4c([nH]3)CN(S(C)(=O)=O)CC4)n[nH]c2c1 CHEMBL4069951 IC50 1.3 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4cccc(Cl)c4)cc23)CC[C@]1(C)N CHEMBL4076823 IC50 1.3 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)ccc1OC1CC1)c1cnn2cccnc12 CHEMBL4762168 Ki 1.3 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Cl)[nH]n1 CHEMBL1231124 IC50 1.3 nM
O=C(Nc1sc(-c2ccc(CN3CC(F)C3)cc2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3923734 Ki 1.31 nM
CNC(=O)CN1CCC(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3954749 Ki 1.32 nM
CN1CCC2C(C1)OCCN2C(=O)Cn1cc(NC(=O)c2c(N)nn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3898224 Ki 1.33 nM
CCOC(=O)[C@@H](N)CCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3909987 Ki 1.34 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@@](O)(CSc3ccccn3)C2)CC1 CHEMBL3652368 IC50 1.36 nM
O=C(Nc1sc(N2CC(N3CCCCC3)C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3922979 Ki 1.36 nM
C[C@@H](Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1)N(C)C CHEMBL3925409 Ki 1.37 nM
O=C(Nc1sc(N2CCN(CC(F)(F)F)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3950547 Ki 1.38 nM
CN1C[C@@H]2C[C@H]1CN2C(=O)Cn1cc(NC(=O)c2c(N)nn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3949658 Ki 1.39 nM
N#CCc1ccccc1NCc1ccc(-c2cccc3nc(NC(=O)C4CC4)nn23)cc1 CHEMBL3360351 IC50 1.4 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccccc4)cc23)CC[C@]1(C)C(N)=O CHEMBL3671828 IC50 1.4 nM
C[C@]1(F)CCC[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cccc(C(N)=O)c3)cc12 CHEMBL3666890 IC50 1.4 nM
C[C@@H]1[C@H]2CN(C(=O)C(C)(C)O)C[C@H]2C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)cc12 CHEMBL3667475 IC50 1.4 nM
Brc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)o1 CHEMBL3979340 IC50 1.4 nM
C[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C4CC4)c3)nc12 CHEMBL3956402 IC50 1.4 nM
O=C1c2cnc3[nH]ccc3c2N([C@H]2CC[C@H](CNS(=O)(=O)C3CC3)CC2)CN1CC(F)(F)F CHEMBL3981673 IC50 1.4 nM
O=C1NCN([C@H]2CC[C@H](CNC3(C(F)(F)F)CC3)CC2)c2c1cnc1[nH]ccc21 CHEMBL3938113 IC50 1.4 nM
O=C1c2cnc3[nH]ccc3c2N([C@H]2CC[C@H](CN3CCCS3(=O)=O)CC2)CN1C1CC1 CHEMBL3911589 IC50 1.4 nM
CN(CC(F)(F)F)C[C@H]1CC[C@H](N2CNC(=O)c3cnc4[nH]ccc4c32)CC1 CHEMBL3930342 IC50 1.4 nM
N#Cc1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)cc1C1CC1 CHEMBL4098999 IC50 1.4 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CN(S(=O)(=O)c2cccc([N+](=O)[O-])c2)CC12CC2 CHEMBL4279526 IC50 1.4 nM
CCOc1ccc(Cl)cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12 CHEMBL4781087 Ki 1.4 nM
Cc1ccc(OC(F)F)c(-c2n[nH]cc2NC(=O)c2cnn3cccnc23)c1 CHEMBL4760135 Ki 1.4 nM
CN1CCN(CCCN2CCC(n3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)C1=O CHEMBL3941957 Ki 1.42 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@H](NC(=O)OC(C)(C)C)C2)CC1 CHEMBL3652299 IC50 1.44 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@@H](O)C2)CC1 CHEMBL3652312 IC50 1.44 nM
CN(CCOc1ccccc1Br)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3907313 Ki 1.45 nM
O=C(CNCCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1)OC1CCCC1 CHEMBL3894756 Ki 1.45 nM
O=C(Nc1cn(CC(O)CN2CCOCC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3894603 Ki 1.46 nM
CNC(=O)CCCN1CCC(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3913141 Ki 1.47 nM
CN1CCC2(CC1)CN(C(=O)Cn1cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n1)CCO2 CHEMBL3966652 Ki 1.49 nM
NC(=O)c1cnc(N[C@H](C2CC2)C(F)(F)F)c2c1[nH]c1cc(-c3cnc(N)nc3)ccc12 CHEMBL1835153 IC50 1.5 nM
Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](NCCC#N)CC1 CHEMBL2159205 Ki 1.5 nM
N#CCC(=O)N1CCC[C@@H](n2nnc3cnc4[nH]ccc4c32)C1 CHEMBL2392500 Ki 1.5 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1n1c(=O)[nH]c2cnc3[nH]ccc3c21 CHEMBL3593591 IC50 1.5 nM
COc1ccc(Cl)cc1-c1nn(CC(O)(C(F)(F)F)C(F)(F)F)cc1NC(=O)c1cnn2cccnc12 CHEMBL3639663 Ki 1.5 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4cc(C(=O)c5ccc(Oc6ccccc6F)cc5OCC(C)NN)cnc4[nH]3)n[nH]c2c1 CHEMBL3644642 IC50 1.5 nM
C[C@H]1CN(C(=O)CC#N)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccc(F)nc3)cc12 CHEMBL3672455 IC50 1.5 nM
CO[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccc(C#N)cc3)cc12 CHEMBL3672468 IC50 1.5 nM
Brc1csc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)c1 CHEMBL3896566 IC50 1.5 nM
O[C@H](CNC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1)c1ccccc1 CHEMBL4112919 IC50 1.5 nM
O=C(CC(F)(F)F)NC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3920329 IC50 1.5 nM
FC(F)(F)C(F)(F)CN[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3911096 IC50 1.5 nM
O=C(Nc1sc(CN2CCCCC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3946179 Ki 1.5 nM
CN(CC(F)(F)F)C[C@H]1CC[C@H](N2CN(C)C(=O)c3cnc4[nH]ccc4c32)CC1 CHEMBL3892444 IC50 1.5 nM
CCNC(=O)CCCN1CCC(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3983381 Ki 1.53 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC(c3nnn[nH]3)C2)CC1 CHEMBL3652383 IC50 1.55 nM
O=C(CCCN1CCC(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1)NC1COC1 CHEMBL3914878 Ki 1.55 nM
CN1CCCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3975210 Ki 1.55 nM
O=C(Nc1cn(C2CCN(CCCN3CCCC3=O)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3974801 Ki 1.56 nM
CCc1cc(O)c(F)cc1-c1cc(NCCNC)c2nc(N)ncc2c1 CHEMBL5076068 pIC50 1.585 nM
CCc1cc(O)c(F)cc1-c1cc(NC2CCN(C)CC2)c2nc(N)ncc2c1 CHEMBL5077126 pIC50 1.585 nM
COCCC1(C(N)=O)CCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)CC1 CHEMBL3652317 IC50 1.59 nM
OC[C@@H](O)c1nc2cnc3[nH]ccc3c2n1C1CCCCC1 CHEMBL2386645 Ki 1.6 nM
COc1ncc(Cl)cc1-c1nn(CC(=O)N(C)C)cc1NC(=O)c1cnn2cccnc12 CHEMBL3667529 Ki 1.6 nM
O=c1[nH]ccc(NC2CCNCC2)c1-c1nc2ccccc2[nH]1 CHEMBL3781196 IC50 1.6 nM
COc1ccc(-c2cc3c(N[C@@H]4CN(C(=O)CC#N)C[C@@H]4C)c(C(N)=O)cnn3c2)cn1 CHEMBL3667465 IC50 1.6 nM
CC(NC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1)c1ccc(F)c(F)c1 CHEMBL3957990 IC50 1.6 nM
Fc1cc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)ccc1Cl CHEMBL3986377 IC50 1.6 nM
Clc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)o1 CHEMBL3979988 IC50 1.6 nM
N#CCC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3944859 IC50 1.6 nM
CN1CN([C@H]2CC[C@H](CNC3(C(F)(F)F)CC3)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3903817 IC50 1.6 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccccc4C#N)cc23)CC[C@]1(C)N CHEMBL4083798 IC50 1.6 nM
CN(c1ncnc2[nH]ccc12)N1CCCC(C(=O)NCC#N)C1 CHEMBL5172892 IC50 1.6 nM
CN(c1ncnc2[nH]ccc12)N1CCCC(C(=O)NCC(F)F)C1 CHEMBL5202063 IC50 1.6 nM
O=C(Nc1cn(C2CCNCC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3985468 Ki 1.62 nM
O=C(Nc1sc(-c2ccncc2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3978806 Ki 1.63 nM
CC(=O)NCCCN1CCC(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3946737 Ki 1.65 nM
CC(=O)NCC1CCCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 CHEMBL3652293 IC50 1.66 nM
NC(=O)CCCN1CCC(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3985698 Ki 1.67 nM
CN(C)CC(O)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3915738 Ki 1.68 nM
COC[C@@H]1CCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 CHEMBL3652344 IC50 1.69 nM
CC1(n2cnc3cnc4[nH]ccc4c32)CCN(S(C)(=O)=O)CC1 CHEMBL2152409 Ki 1.7 nM
CS(=O)(=O)NCCc1nc2cnc3[nH]ccc3c2n1C1CCN(CCC#N)CC1 CHEMBL2206624 Ki 1.7 nM
C[C@@H]1C[C@@H](CS(=O)(=O)N2CCC[C@@H](O)C2)CC[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL3652398 IC50 1.7 nM
CO[C@@H]1CCCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 CHEMBL3652331 IC50 1.7 nM
CN[C@H]1CC2OC([C@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(O)=NC4 CHEMBL3975634 IC50 1.7 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(Cc3cnc5ccccc5c3)C4)n[nH]c2c1 CHEMBL3644636 IC50 1.7 nM
OC1CN(C[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)C1 CHEMBL3966840 IC50 1.7 nM
CSc1ccc(C(O)(CN[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)C(F)(F)F)cc1 CHEMBL3962138 IC50 1.7 nM
CN(C)CC(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3914779 Ki 1.7 nM
O=C(CN1CCOCC1)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3976520 Ki 1.7 nM
C[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)nc12 CHEMBL3929793 IC50 1.7 nM
CCc1cc(O)ccc1-c1ccc2c(C(N)=O)n[nH]c2c1 CHEMBL4096219 IC50 1.7 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4cc[nH]n4)cc23)CC[C@]1(C)N CHEMBL4060984 IC50 1.7 nM
CN(C)C(=O)CCCN(C)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3977319 Ki 1.72 nM
O=C(Nc1cn(CC(O)CN2CCCCC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3983445 Ki 1.73 nM
O=C(Nc1sc(N2CCC(N3CC(F)(F)C3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3983975 Ki 1.74 nM
Cc1nc2cnc3[nH]ccc3c2n1[C@@H]1CCC[C@@H](O)C1 CHEMBL2159210 Ki 1.8 nM
CC[C@@H](O)c1nc2cnc3[nH]ccc3c2n1C1CCCCC1 CHEMBL2386643 Ki 1.8 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@@](O)(Cn3cccn3)C2)CC1 CHEMBL3652361 IC50 1.8 nM
CCOc1ncc(-c2cc3c(N[C@@H]4CN(C(=O)C5(C#N)CC5)C[C@@H]4CF)c(C(N)=O)cnn3c2)cn1 CHEMBL3672464 IC50 1.8 nM
c1cc2c(ncn3nnc(C4CCN(Cc5csnn5)CC4)c23)[nH]1 CHEMBL3894161 IC50 1.8 nM
O=C(NCC(F)(F)F)[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3894516 IC50 1.8 nM
C[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C[C@@H](O)C(F)(F)F)c3)nc12 CHEMBL3957930 IC50 1.8 nM
CS(=O)(=O)NC[C@H]1CC[C@H](N2CN(C3CC3)C(=O)c3cnc4[nH]ccc4c32)CC1 CHEMBL3975691 IC50 1.8 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(Cc3ccccc3)CC4)n[nH]c2c1 CHEMBL4097152 IC50 1.8 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)ccc1OC(F)F)c1cncc2ccoc12 CHEMBL4778449 Ki 1.8 nM
CCN1CCN(c2ccc(Nc3ncc4scc(-c5cccc(NS(C)(=O)=O)c5)c4n3)cc2)CC1 CHEMBL4846921 IC50 1.8 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(C(F)(F)F)cn2)[C@H](C)C1 CHEMBL5410919 IC50 1.86 nM
C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](C#N)CC1 CHEMBL2386633 Ki 1.9 nM
CC[C@H]1CN(c2ccc(C#N)cn2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)cc12 CHEMBL3672452 IC50 1.9 nM
FC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3942741 IC50 1.9 nM
Cc1ccc(CNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)s1 CHEMBL3891947 IC50 1.9 nM
Fc1ccc(CCNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3949323 IC50 1.9 nM
c1cc2c(ncn3nnc([C@H]4CC[C@H](CNC5CC5)CC4)c23)[nH]1 CHEMBL3963443 IC50 1.9 nM
OC(CN[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1)(c1cccnc1)C(F)(F)F CHEMBL3926894 IC50 1.9 nM
COc1ccc(C(O)(CN[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)C(F)(F)F)cn1 CHEMBL3985391 IC50 1.9 nM
CN(CC(F)(F)F)C1CCN(C(=O)c2ccc(-n3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)cc2)CC1 CHEMBL3924554 Ki 1.9 nM
CCN1CN([C@H]2CC[C@H](CNS(=O)(=O)CC(F)(F)F)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3893247 IC50 1.9 nM
N#CCN1CN([C@H]2CC[C@H](CNC3(C(F)(F)F)CC3)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3983594 IC50 1.9 nM
COc1ccc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)cn1 CHEMBL4080797 IC50 1.9 nM
CN(c1ncnc2[nH]ccc12)[C@@H]1CCN(S(=O)(=O)c2cccc([N+](=O)[O-])c2)C1 CHEMBL4225016 IC50 1.9 nM
Cc1cncc(Nc2cc(NC3CCN(c4ccc(C#N)cn4)CC3)c(C(N)=O)cn2)n1 CHEMBL4470355 IC50 1.9 nM
COc1ccc(Cl)cc1-c1nn(C)cc1NC(=O)c1cncc2cccnc12 CHEMBL4795297 Ki 1.9 nM
CN(c1ncnc2[nH]ccc12)N1CCC(C(=O)NCC(F)(F)F)C1 CHEMBL5173932 IC50 1.9 nM
CCOC(=O)C(CC)n1c(=O)c2cc(OC)c(OC)cc2c2cnc3[nH]ccc3c21 CHEMBL4286762 IC50 1.91 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@@](O)(c3ccccc3)C2)CC1 CHEMBL3652362 IC50 1.92 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(C#N)cc2)[C@H](C)C1 CHEMBL4744772 IC50 1.93 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(CCCCOCCc3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3970566 Ki 1.99 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@H](C)CO)c2nc(N)ncc2c1 CHEMBL5074310 pIC50 1.995 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@@H]2CCCN(C)C2)c2nc(N)ncc2c1 CHEMBL5087255 pIC50 1.995 nM
O=c1[nH]ccc2c3[nH]c(-c4ccccc4Cl)nc3c3ccc(F)cc3c12 CHEMBL261386 IC50 2.0 nM
c1ncc(CN2CCC(n3cnc4cnc5[nH]ccc5c43)CC2)cn1 CHEMBL2152307 Ki 2.0 nM
Cc1nc2cnc3[nH]ccc3c2n1C1CCNCC1(F)F CHEMBL2159204 Ki 2.0 nM
C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@@H](NCC(F)(F)F)C1 CHEMBL2385096 Ki 2.0 nM
CCN1CCC(n2c([C@@H](C)O)nc3cnc4[nH]ccc4c32)C(F)(F)C1 CHEMBL2386648 Ki 2.0 nM
N#C[C@H]1CCC[C@H]1Nc1nc(-c2cn[nH]c2)nc2c(=O)[nH]ccc12 CHEMBL2436944 Ki 2.0 nM
C[C@H](N[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)cc3)n2)[C@@H](C#N)C1)C1CC1 CHEMBL3647763 IC50 2.0 nM
N#C[C@H]1CCCCC1n1cc(C(N)=O)c(Nc2ccc3c(c2)CCC(=O)N3)n1 CHEMBL3699512 IC50 2.0 nM
COCC(C)N(C)[C@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3647812 IC50 2.0 nM
N#C[C@H]1CCCCC1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)F)c(CO)c2)n1 CHEMBL3702885 IC50 2.0 nM
CS(=O)(=O)N[C@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647913 IC50 2.0 nM
C[C@]1(O)CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)c(F)c3)n2)[C@@H](C#N)C1 CHEMBL3647847 IC50 2.0 nM
N#C[C@H]1C[C@@H](NCCC(F)(F)F)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647739 IC50 2.0 nM
C[C@](O)(c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cn1)C(F)(F)F CHEMBL3699535 IC50 2.0 nM
N#C[C@H]1C[C@H](NCc2ccccc2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccnc(F)c2)n1 CHEMBL3703090 IC50 2.0 nM
CC(C)(c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1F)[C@H](O)C(F)(F)F CHEMBL3699533 IC50 2.0 nM
CC(C)(O)CN[C@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3647794 IC50 2.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccnc(F)c2)n1 CHEMBL3699503 IC50 2.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)nc2)n1 CHEMBL3702922 IC50 2.0 nM
N#C[C@@H]1C[C@@H](NC2CCC2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3647828 IC50 2.0 nM
CN[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)c(F)c3)n2)[C@@H](C#N)C1 CHEMBL3703018 IC50 2.0 nM
N#C[C@H]1C[C@H](N2CC(O)(C(F)(F)F)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3647774 IC50 2.0 nM
CC(C)(c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1F)[C@@H](O)C(F)(F)F CHEMBL3699534 IC50 2.0 nM
N#C[C@H]1C[C@@H](N2CC3(CCC3)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3702997 IC50 2.0 nM
N#C[C@H]1C[C@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)c(F)c2)n1 CHEMBL3703016 IC50 2.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)c(F)c2)n1 CHEMBL3699553 IC50 2.0 nM
N#C[C@H]1C[C@@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccnc(F)c2)n1 CHEMBL3703078 IC50 2.0 nM
CS(=O)(=O)C1CN(C(=O)[C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(Cl)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3647899 IC50 2.0 nM
CN[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3703021 IC50 2.0 nM
N#C[C@H]1C[C@@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)c(Cl)c2)n1 CHEMBL3647864 IC50 2.0 nM
CN(CCC(F)(F)F)[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647744 IC50 2.0 nM
CC1CN([C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(Cl)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3703067 IC50 2.0 nM
CC1(N[C@H]2CCC(n3cc(C(N)=O)c(Nc4ccccc4)n3)[C@@H](C#N)C2)CC1 CHEMBL3647789 IC50 2.0 nM
N#C[C@H]1CCCCC1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3699502 IC50 2.0 nM
N#C[C@H]1C[C@@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(OC(F)F)nc2)n1 CHEMBL3702939 IC50 2.0 nM
CC1(C)CN([C@@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3647776 IC50 2.0 nM
N#C[C@H]1CCCCC1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3699519 IC50 2.0 nM
CC1(CN[C@H]2CCC(n3cc(C(N)=O)c(Nc4ccc(Cl)cc4)n3)[C@@H](C#N)C2)COC1 CHEMBL3647790 IC50 2.0 nM
CN[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)c(F)c3)n2)[C@@H](C#N)C1 CHEMBL3703022 IC50 2.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)F)nc2)n1 CHEMBL3699560 IC50 2.0 nM
N#C[C@H]1CCCCC1n1cc(C(N)=O)c(Nc2ccc(-c3cn[nH]c3)nc2)n1 CHEMBL3702933 IC50 2.0 nM
CC(C)(C)OC(=O)N[C@@H]1CC[C@H](C#N)C(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1 CHEMBL3647925 IC50 2.0 nM
N#C[C@H]1C[C@@H](O)CCC1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3699480 IC50 2.0 nM
N#C[C@H]1C[C@H](OCC2CC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@@H](O)C(F)(F)F)cc2)n1 CHEMBL3702963 IC50 2.0 nM
C[C@H](N[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)c(F)c3)n2)[C@@H](C#N)C1)C1CC1 CHEMBL3703045 IC50 2.0 nM
CS(=O)(=O)c1ccc(Nc2nn(C3CCCC[C@@H]3C#N)cc2C(N)=O)cc1F CHEMBL3699509 IC50 2.0 nM
CC1(C)CN([C@@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccnc(F)c4)n3)[C@@H](C#N)C2)C1 CHEMBL3647719 IC50 2.0 nM
CN(C)[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3703092 IC50 2.0 nM
C[C@@H]1C[C@@H](C)N1[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3702989 IC50 2.0 nM
N#C[C@H]1C[C@@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)c(F)c2)n1 CHEMBL3647850 IC50 2.0 nM
N#C[C@H]1C[C@@H](NCC(F)(F)F)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3703076 IC50 2.0 nM
N#C[C@@H]1CC(CO)CCC1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3699488 IC50 2.0 nM
N#C[C@H]1C[C@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccccc2)n1 CHEMBL3702958 IC50 2.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2cnc3ccc(F)cc3c2)n1 CHEMBL3699549 IC50 2.0 nM
N#C[C@H]1C[C@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(OC(F)(F)F)cc2)n1 CHEMBL3703044 IC50 2.0 nM
COCCN(C)[C@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3647811 IC50 2.0 nM
COC(C)(C)CN[C@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3647801 IC50 2.0 nM
N#C[C@H]1C[C@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3703077 IC50 2.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2cnc3cc(F)ccc3c2)n1 CHEMBL3699542 IC50 2.0 nM
N#C[C@H]1CC(N2CC[C@@H](F)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647735 IC50 2.0 nM
CN(C)[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)c(F)c3)n2)[C@@H](C#N)C1 CHEMBL3703020 IC50 2.0 nM
[C-]#[N+][C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(CC(=O)O)cc2)n1 CHEMBL3647928 IC50 2.0 nM
N#C[C@H]1C[C@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)c(F)c2)n1 CHEMBL3702955 IC50 2.0 nM
[C-]#[N+][C@@H]1C[C@H](OCC2CC2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccnc(F)c2)n1 CHEMBL3702959 IC50 2.0 nM
N#C[C@H]1C[C@@H](N[C@H](C2CC2)C(F)(F)F)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3647765 IC50 2.0 nM
N#C[C@@H]1C[C@@H](NCC2CCC2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3647827 IC50 2.0 nM
CC(C)NC(=O)O[C@@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647869 IC50 2.0 nM
CS(=O)(=O)c1ccc(Nc2nn(C3CCCC[C@H]3C#N)cc2C(N)=O)cc1 CHEMBL3699476 IC50 2.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)NCc3ccc(C(F)(F)F)cc3)cc2)n1 CHEMBL3702917 IC50 2.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3702926 IC50 2.0 nM
N#C[C@H]1C[C@@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)c(F)c2)n1 CHEMBL3703015 IC50 2.0 nM
Cn1cc(-c2ccc(Nc3nn(C4CCCC[C@@H]4C#N)cc3C(N)=O)cn2)cn1 CHEMBL3702932 IC50 2.0 nM
N#C[C@H]1C[C@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)F)nc2)n1 CHEMBL3703028 IC50 2.0 nM
COCC(C)(C)N(C)[C@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3647807 IC50 2.0 nM
N#C[C@H]1C[C@H](NC2(O)CC2)CCC1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647793 IC50 2.0 nM
N#C[C@H]1C[C@@H](NC2(CO)CC2)CCC1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647796 IC50 2.0 nM
O=c1[nH]ccc(NC2CCOCC2)c1-c1nc2ccccc2[nH]1 CHEMBL3781427 IC50 2.0 nM
O=c1[nH]ccc(N[C@H]2CC[C@@H](NCC(F)(F)F)CC2)c1-c1nc2ccccc2[nH]1 CHEMBL3780647 IC50 2.0 nM
CC[C@@H]1CN(C(=O)[C@H](C)O)CC[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC(C)C)c3)cc12 CHEMBL3667485 IC50 2.0 nM
Fc1cc(C(F)(F)F)ccc1CN1CCC(c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3974989 IC50 2.0 nM
Fc1cc(C(F)(F)F)cc(F)c1CN1CCC(c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3949257 IC50 2.0 nM
N#CCCN(CCC#N)C1CCC(c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3953229 IC50 2.0 nM
CN(c1ccc(C(=O)NC2c3ccccc3C[C@H]2O)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL4108544 IC50 2.0 nM
CC(C)(C)OC(=O)N1CC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(=O)N4CCS(=O)(=O)CC4)cc3)n2)C1 CHEMBL4109520 IC50 2.0 nM
C[C@H]1C[C@](CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN1C(=O)OC(C)(C)C CHEMBL3916449 IC50 2.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1 CHEMBL3912439 IC50 2.0 nM
COc1cc(F)cc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)c1 CHEMBL3895843 IC50 2.0 nM
Cc1cc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)cnc1C CHEMBL3950086 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2ccc(F)cc2)CC1 CHEMBL3916493 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2ccc(F)c(F)c2)CC1 CHEMBL3964457 IC50 2.0 nM
CC(C)OC(=O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1 CHEMBL3948482 IC50 2.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)CC1 CHEMBL3903692 IC50 2.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cc(F)cc(F)c3)n2)CC1 CHEMBL3949440 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(Cc2cccc(F)c2)CC1 CHEMBL3939054 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ccnc3[nH]ccc23)CC1 CHEMBL3968775 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ccc3[nH]ccc3c2)CC1 CHEMBL3942622 IC50 2.0 nM
Cn1nccc1CN1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1 CHEMBL3923485 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2cccc(F)n2)CC1 CHEMBL3936802 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2cccc3ccnn23)CC1 CHEMBL3952017 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ccc(F)cn2)CC1 CHEMBL3984973 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(Cc2ccon2)CC1 CHEMBL3892671 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(Cc2ccc(F)cn2)CC1 CHEMBL3935250 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(Cc2cncc(F)c2)CC1 CHEMBL3911829 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(Cc2ccc3cc[nH]c3c2)CC1 CHEMBL3908733 IC50 2.0 nM
COc1ccccc1CN1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1 CHEMBL3914006 IC50 2.0 nM
CC(C)(CO)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1 CHEMBL3956545 IC50 2.0 nM
C[C@@H](OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1)C(F)(F)F CHEMBL4110226 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)OC2COC2)CC1 CHEMBL3969749 IC50 2.0 nM
COCC(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1 CHEMBL3944827 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)OCc2ccccc2F)CC1 CHEMBL3947243 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)OCc2cccnc2)CC1 CHEMBL3917676 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)OCc2ccncc2)CC1 CHEMBL3893183 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CN(C(=O)OCCF)C1 CHEMBL4111807 IC50 2.0 nM
CCC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1 CHEMBL3969943 IC50 2.0 nM
C/C=C/C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1 CHEMBL3936839 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)C2CCCCC2)CC1 CHEMBL3909103 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)c2ccsc2)CC1 CHEMBL3953465 IC50 2.0 nM
Cn1cc(C(=O)N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccnc(F)c4)n3)CC2)cn1 CHEMBL3982937 IC50 2.0 nM
CC(C)[C@@H](O)C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1 CHEMBL4108853 IC50 2.0 nM
CC(C)[C@H](O)C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1 CHEMBL3957574 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(C(=O)C2(C(F)(F)F)CC2)CC1 CHEMBL3982364 IC50 2.0 nM
CC(O)(C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1)C(F)F CHEMBL3898144 IC50 2.0 nM
CC(C)S(=O)(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1 CHEMBL3985654 IC50 2.0 nM
Cn1cnc(S(=O)(=O)N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccccc4)n3)CC2)c1 CHEMBL3907066 IC50 2.0 nM
Cc1ccc(NC(=O)N2CC(CC#N)(n3cc(C(N)=O)c(Nc4ccccc4)n3)C2)cc1 CHEMBL4114891 IC50 2.0 nM
CCOc1ccc(NC(=O)N2CC(CC#N)(n3cc(C(N)=O)c(Nc4ccccc4)n3)C2)cc1 CHEMBL3946078 IC50 2.0 nM
CCc1ccc(NC(=O)N2CC(CC#N)(n3cc(C(N)=O)c(Nc4ccccc4)n3)C2)cc1 CHEMBL3941640 IC50 2.0 nM
CC(C)NC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1 CHEMBL3944525 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(Nc2ccccn2)CC1 CHEMBL3931773 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(NC2CCCCC2)CC1 CHEMBL3909143 IC50 2.0 nM
N#CCC1(C2C=C(C(N)=O)C(Nc3ccc(F)cc3)=N2)CCC(NC2CCOCC2)CC1 CHEMBL3973507 IC50 2.0 nM
CC(C)(C)OC(=O)N1CC[C@@](CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)[C@H](F)C1 CHEMBL4106951 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)O[C@@H]2CCOC2)CC1 CHEMBL4109194 IC50 2.0 nM
CN(CCCN1CCC(n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1)C(=O)c1ccccc1 CHEMBL3964224 Ki 2.0 nM
CN(CC1(C#N)CCCCC1)C1CCN(C(=O)C2CCN(c3nc(-c4cc(Cl)ccc4OC(F)F)c(NC(=O)c4cnn5cccnc45)s3)CC2)CC1 CHEMBL3974690 Ki 2.0 nM
N#C[C@@H]1CCN(C(=O)OCc2ccccc2)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3951673 IC50 2.0 nM
N#C[C@@H]1CCN(Cc2cnccn2)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3944948 IC50 2.0 nM
N#C[C@@H]1CCN(Cc2ccon2)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3957147 IC50 2.0 nM
N#C[C@@H]1CCN(Cc2cocn2)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3982494 IC50 2.0 nM
Cn1ccc(CN2CC[C@@H](C#N)[C@H](n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)C2)n1 CHEMBL3968173 IC50 2.0 nM
N#C[C@@H]1CCN(Cc2cscn2)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3897013 IC50 2.0 nM
N#C[C@@H]1CCN(Cc2ncco2)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3968880 IC50 2.0 nM
Cn1nccc1CN1CC[C@@H](C#N)[C@H](n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1 CHEMBL3892314 IC50 2.0 nM
CCn1ccnc1CN1CC[C@@H](C#N)[C@H](n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1 CHEMBL3935618 IC50 2.0 nM
N#C[C@@H]1CN(Cc2cccc(F)n2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL4112701 IC50 2.0 nM
C[C@@](O)(c1ccc(Nc2nn([C@@H]3COCC[C@H]3C#N)cc2C(N)=O)cc1)C(F)F CHEMBL3959433 IC50 2.0 nM
N#C[C@H]1COCC[C@@H]1n1cc(C(N)=O)c(Nc2ccnc(F)c2)n1 CHEMBL3895755 IC50 2.0 nM
N#C[C@@H]1CS(=O)(=O)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL4107562 IC50 2.0 nM
C[C@@]1(C#N)CS(=O)(=O)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL4114824 IC50 2.0 nM
Cn1cc(Nc2ncc(Cl)c(NC3CCC4(CCNC4)CC3)n2)cn1 CHEMBL3970415 IC50 2.0 nM
Cn1cc(Nc2ncc(Cl)c(NC3CCC4CN(C(=O)CC#N)CC4C3)n2)cn1 CHEMBL3890379 IC50 2.0 nM
Cn1cc(Nc2ncc(Cl)c(NC3CCC4(CC3)CCN(C(=O)CC#N)CC4)n2)cn1 CHEMBL3939630 IC50 2.0 nM
Cn1cc(Nc2ncc(Cl)c(NC3CCC4(CC3)CCN(S(C)(=O)=O)CC4)n2)cn1 CHEMBL3929488 IC50 2.0 nM
Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(C(=O)C(F)(F)F)CC4C3)n2)cn1 CHEMBL3906000 IC50 2.0 nM
Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC(F)(F)F)CC4C3)n2)cn1 CHEMBL3961729 IC50 2.0 nM
Cc1nn(C)cc1Nc1ncc(Cl)c(NC2CC3CN(C(=O)CC#N)CC3C2)n1 CHEMBL3940613 IC50 2.0 nM
CCn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(C(=O)C5(C#N)CC5)C[C@H]4CF)c3n2)cn1 CHEMBL3928562 IC50 2.0 nM
CN1CN([C@H]2CC[C@H](CNCC(F)F)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3967688 IC50 2.0 nM
CN1CN([C@H]2CC[C@H](CNCC#N)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3976204 IC50 2.0 nM
CN1CN([C@H]2CC[C@H](CN3CC(O)C3)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3950208 IC50 2.0 nM
Cc1ccc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)cn1 CHEMBL4060444 IC50 2.0 nM
N#CCC1(n2cc(-c3ncnc4[nH]ccc34)cn2)CN(C2CCN(C(=O)c3ccnc(C(F)(F)F)c3F)CC2)C1 CHEMBL3622820 IC50 2.0 nM
O=C(Nc1nc2cccc([C@H]3CC[C@@H](NC(=O)[C@@H]4CC4(F)F)CC3)n2n1)C1CC1 CHEMBL5197758 IC50 2.0 nM
Cc1cnc(Nc2cnn(C)c2)nc1N1CC2CCCC(C1)N2CCC#N CHEMBL5412619 IC50 2.0 nM
CN1CC[C@H]2[C@@H](CCN2C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3925919 Ki 2.07 nM
CN(C)C[C@H]1CCCN1C(=O)Cn1cc(NC(=O)c2c(N)nn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL4108609 Ki 2.08 nM
CS(=O)(=O)NCCc1nc2cnc3[nH]ccc3c2n1C1CCCCC1 CHEMBL2206634 Ki 2.1 nM
CS(=O)(=O)NCc1nc2cnc3[nH]ccc3c2n1C1CCCSC1 CHEMBL2206629 Ki 2.1 nM
N#CCCN1CCC(n2nnc3cnc4[nH]ccc4c32)CC1 CHEMBL2392488 Ki 2.1 nM
COc1ccc(Cl)cc1-c1c(NC(=O)c2c(N)nn3cccnc23)cnn1CC(N)=O CHEMBL3667521 Ki 2.1 nM
NC(=O)c1cnn2cc(-c3ccc(F)cc3)cc2c1NC12CC3CC(O)(CC(O)(C3)C1)C2 CHEMBL3671817 IC50 2.1 nM
FC(F)(F)c1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)cn1 CHEMBL3897798 IC50 2.1 nM
CC(=O)OC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3892296 IC50 2.1 nM
N#CCNC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3955720 IC50 2.1 nM
N#CCNC[C@H]1CC[C@H](N2CNC(=O)c3cnc4[nH]ccc4c32)CC1 CHEMBL3981587 IC50 2.1 nM
CCc1cc(O)ccc1-c1ccc2c(-c3nc4c([nH]3)CN(C)CC4)n[nH]c2c1 CHEMBL4066236 IC50 2.1 nM
Cc1[nH]nc2[nH]c(=O)cc([C@H]3CC[C@H](CC(=O)N4CCC(c5ccccc5)C4)CC3)c12 CHEMBL4639606 IC50 2.1 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)ccc1OC(F)(F)F)c1cnn2cccnc12 CHEMBL4790609 Ki 2.1 nM
COc1cc(Nc2ncc(C)c(Nc3ccc4oc(=O)[nH]c4c3)n2)cc(C)c1F CHEMBL4594441 IC50 2.1 nM
O=C(Nc1cn(C2CCN(CCCN3CCOCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3894548 Ki 2.12 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCCC(C(=O)O)C2)CC1 CHEMBL3652289 IC50 2.13 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(F)nc4)cc23)CC[C@]1(C)C(N)=O CHEMBL3671830 IC50 2.2 nM
N#Cc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)c(F)c1 CHEMBL3899634 IC50 2.2 nM
N#Cc1ccc(N[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3906857 IC50 2.2 nM
FC(F)(F)CN[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3932456 IC50 2.2 nM
C[C@H](O)Cn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(C(=O)C5(C#N)CC5)C[C@H]4C)c3n2)cn1 CHEMBL3957457 IC50 2.2 nM
Cc1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(C(=O)C5(C#N)CC5)C[C@H]4C)c3n2)ccn1 CHEMBL3980081 IC50 2.2 nM
CN1CN([C@H]2CC[C@H](CNCC(F)(F)F)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3892672 IC50 2.2 nM
N#CCN1CN([C@H]2CC[C@H](CNCC(F)(F)F)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3901392 IC50 2.2 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)c3cnc(N5CCCCC5)cn3)C4)n[nH]c2c1 CHEMBL3644620 IC50 2.2 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(F)nc4)cc23)CC[C@]1(C)N CHEMBL4098840 IC50 2.2 nM
COc1cc(F)c(Cl)cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12 CHEMBL4755407 Ki 2.2 nM
CN(CCCc1ccccc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3898708 Ki 2.23 nM
CN(CCCC(N)=O)C1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3935428 Ki 2.23 nM
O=C(Nc1sc(N2CCC(N3CC(F)C3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3898459 Ki 2.28 nM
COc1ccc(F)cc1-c1nn(CC2(O)CCOCC2)cc1NC(=O)c1cnn2cccnc12 CHEMBL3667525 Ki 2.3 nM
N#CC=C1CCC(c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3985220 IC50 2.3 nM
CC[C@@H]1CN(c2ccc(C#N)cn2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)nc12 CHEMBL3914152 IC50 2.3 nM
C[C@@H]1CCN(C(=O)N2CC[C@@H](S(=O)(=O)c3cccc(O)c3)C2)C[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL4089515 IC50 2.3 nM
COc1cc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)ccn1 CHEMBL4069127 IC50 2.3 nM
CC[C@H]1CN(c2ccc(C#N)cn2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)nc12 CHEMBL5285673 IC50 2.3 nM
O=C(Nc1cn(C2CCN(CCCN3CCSCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3960068 Ki 2.32 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2cnc(C(F)(F)F)nc2)[C@H](C)C1 CHEMBL5393770 IC50 2.34 nM
c1ccc(CN2CCC(n3cnc4cnc5[nH]ccc5c43)CC2)cc1 CHEMBL2152305 Ki 2.4 nM
CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](n2nnc3cnc4[nH]ccc4c32)C1 CHEMBL2392485 Ki 2.4 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@H](CO)C2)CC1 CHEMBL3652333 IC50 2.4 nM
CC1(C)CN(c2ncc(C#N)cn2)CC[C@H]1Nc1c(C(N)=O)cnn2cc(N3CCC(CCCC(=O)O)C3=O)cc12 CHEMBL3667480 IC50 2.4 nM
Ic1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)o1 CHEMBL3923513 IC50 2.4 nM
Clc1ccc(C2(NC[C@H]3CC[C@H](c4nnn5cnc6[nH]ccc6c45)CC3)COC2)cc1 CHEMBL3941925 IC50 2.4 nM
COc1ccc(C(O)(CN[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)C(F)(F)F)cc1OC CHEMBL3949248 IC50 2.4 nM
CCCn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(c5ncc(C#N)cn5)C[C@H]4C)c3n2)cn1 CHEMBL3965169 IC50 2.4 nM
COc1ccc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(C(=O)C5(C#N)CC5)C[C@H]4C)c3n2)cn1 CHEMBL3980515 IC50 2.4 nM
O=C1NCN([C@H]2CC[C@H](CNCC(F)(F)F)CC2)c2c1cnc1[nH]ccc21 CHEMBL3986613 IC50 2.4 nM
O=C1c2cnc3[nH]ccc3c2N([C@H]2CC[C@H](CNCC(F)(F)F)CC2)CN1C1CC1 CHEMBL3956439 IC50 2.4 nM
Cc1cnccc1-c1cc2c(N[C@@H]3CC[C@](C)(N)C3(C)C)c(C(N)=O)cnn2c1 CHEMBL4084341 IC50 2.4 nM
O=C(CN1CCCCC1)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3966418 Ki 2.43 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2cccc(C#N)c2)C[C@@H]1F CHEMBL5441087 IC50 2.46 nM
CCCCN(CCOc1ccc(C)cc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3961634 Ki 2.47 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(S(=O)(=O)c3ccc(Oc5ccccc5)nc3)C4)n[nH]c2c1 CHEMBL3644622 IC50 2.5 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)c3ccsn3)CC4)n[nH]c2c1 CHEMBL3644625 IC50 2.5 nM
FC(F)(F)c1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3916915 IC50 2.5 nM
FC(F)(F)c1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)o1 CHEMBL3909146 IC50 2.5 nM
Clc1ccc(CCN[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3940782 IC50 2.5 nM
OC(CN[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1)(c1ccc(F)cc1)C(F)(F)F CHEMBL3946125 IC50 2.5 nM
FC1(F)Oc2ccc(CN3CCC(c4nnn5cnc6[nH]ccc6c45)CC3)cc2O1 CHEMBL3964008 IC50 2.5 nM
FC(F)CNC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3911142 IC50 2.5 nM
OC1(C(F)(F)F)CN(C[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)C1 CHEMBL3956945 IC50 2.5 nM
C[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3ccnn3C)nc12 CHEMBL3943940 IC50 2.5 nM
Cc1cc(Nc2nc([C@@H](O)c3ccc(F)cc3)nc3ccccc23)n[nH]1 CHEMBL3939800 Kd 2.5 nM
N#Cc1ccc(N2CCC(Nc3cc(Nc4cnccn4)ncc3C(N)=O)CC2)nc1 CHEMBL4454640 IC50 2.5 nM
CCc1cc(O)c(F)cc1-c1cc(OC)c2nc(N)ncc2c1 CHEMBL5077653 pIC50 2.512 nM
CCc1cc(O)c(F)cc1-c1cc(NCC2CCN(C)CC2)c2nc(N)ncc2c1 CHEMBL5075223 pIC50 2.512 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2C[C@@H](O)[C@@H](O)C2)CC1 CHEMBL3652342 IC50 2.52 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@H](c3ccccn3)C2)CC1 CHEMBL3652378 IC50 2.54 nM
O=C(Nc1cn(CC(=O)N2CCC(N(CCC(F)(F)F)Cc3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3900096 Ki 2.57 nM
CN(CCC#N)C1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3958770 Ki 2.59 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(Cl)nc2)[C@H](C)C1 CHEMBL5427932 IC50 2.59 nM
COC(=O)N[C@H]1CC[C@H](n2c(C)nc3cnc4[nH]ccc4c32)CC1 CHEMBL2159208 Ki 2.6 nM
CS(=O)(=O)NCc1nc2cnc3[nH]ccc3c2n1C1CCCCC1 CHEMBL2206633 Ki 2.6 nM
CC(=O)NCCc1nc2cnc3[nH]ccc3c2n1C1CCCCC1 CHEMBL2206632 Ki 2.6 nM
C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1C1CCN(CC(F)(F)F)CC1 CHEMBL2386646 Ki 2.6 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccccc4)cc23)CC[C@]1(C)NS(C)(=O)=O CHEMBL3671791 IC50 2.6 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(Cc3cccc(O)c3)C4)n[nH]c2c1 CHEMBL3644633 IC50 2.6 nM
Fc1ccc(CNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3984960 IC50 2.6 nM
Clc1ccc(CCNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3926817 IC50 2.6 nM
Clc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)cn1 CHEMBL3977017 IC50 2.6 nM
N#CCN(C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1)C(=O)CC(F)(F)F CHEMBL3952261 IC50 2.6 nM
N#CC(C#N)C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3930389 IC50 2.6 nM
CN1CN([C@H]2CC[C@H](CN(C)S(C)(=O)=O)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3952221 IC50 2.6 nM
O=C1c2cnc3[nH]ccc3c2N([C@H]2CC[C@H](CN3CCCS3(=O)=O)CC2)CN1CC(F)(F)F CHEMBL3957838 IC50 2.6 nM
Cc1nc2cnc3ccc(-c4cc(Cl)c(O)c(Cl)c4)cc3c2n1[C@@H]1CCCN(C)C1 CHEMBL5192754 IC50 2.6 nM
CC(C)(C)OC(=O)N1CC[C@@H](O)[C@H](n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL4109287 Ki 2.64 nM
CN(C)CC1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3912946 Ki 2.69 nM
CN1C[C@@H]2CN(C(=O)c3nc(-c4cc(Cl)ccc4OC(F)F)c(NC(=O)c4cnn5cccnc45)s3)C[C@@H]2C1 CHEMBL3890152 Ki 2.69 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(F)cc2)[C@H](C)C1 CHEMBL5405140 IC50 2.691 nM
CS(=O)(=O)N[C@H]1CC[C@H](n2cnc3cnc4[nH]ccc4c32)CC1 CHEMBL2152422 Ki 2.7 nM
C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@@H]1CCC[C@@H](O)C1 CHEMBL2386627 Ki 2.7 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccccc4C(N)=O)cc23)CC[C@]1(C)N CHEMBL3671808 IC50 2.7 nM
Fc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3922240 IC50 2.7 nM
OC(CNC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1)c1ccccc1 CHEMBL3896784 IC50 2.7 nM
FC(F)(F)C1(NC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)CC1 CHEMBL3916636 IC50 2.7 nM
COC[C@H](O)Cn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(C(=O)C5(C#N)CC5)C[C@H]4C)c3n2)cn1 CHEMBL3921483 IC50 2.7 nM
N#CCN1CN([C@H]2CC[C@H](CNCC(F)F)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3934831 IC50 2.7 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@H](C#N)C2)CC1 CHEMBL3652335 IC50 2.71 nM
CN(CC(F)(F)F)C1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3923526 Ki 2.72 nM
CNS(=O)(=O)[C@H]1CCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 CHEMBL3652352 IC50 2.78 nM
Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CCCOC1 CHEMBL2159200 Ki 2.8 nM
C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CCCOC1 CHEMBL2386653 Ki 2.8 nM
COc1ccc(-c2cccc3nc(Nc4ccc(NC(C)=O)cc4)nn23)cc1 CHEMBL3360330 IC50 2.8 nM
Nc1ccn2ncc(C(=O)Nc3c[nH]nc3-c3cc(Cl)ccc3Cl)c2n1 CHEMBL3670393 Ki 2.8 nM
FCCNC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3972506 IC50 2.8 nM
OC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3906967 IC50 2.8 nM
O=C(NCCc1ccc(F)cc1)[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3972033 IC50 2.8 nM
CC1(O)CN(C[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)C1 CHEMBL3977129 IC50 2.8 nM
CC[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccc4ncccc4c3)nc12 CHEMBL3890332 IC50 2.8 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CN(S(=O)(=O)c2cccc(F)c2)CC12CC2 CHEMBL4289789 IC50 2.8 nM
C[C@H]1CN(C(=O)CC#N)[C@]12CCN(c1ncnc3[nH]ccc13)C2 CHEMBL4297507 IC50 2.8 nM
Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2Cl)n1 CHEMBL2178799 Ki 2.8 nM
C[C@H]1CC(C(=O)CC#N)[C@]12CCN(c1ncnc3[nH]ccc13)C2 CHEMBL5421204 IC50 2.8 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(C(F)(F)F)nc2)[C@H](C)C1 CHEMBL5435417 IC50 2.86 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@H](CO)C2)CC1 CHEMBL3652304 IC50 2.88 nM
FC(F)(F)CN1CCC(n2cnc3cnc4[nH]ccc4c32)CC1 CHEMBL2152400 Ki 2.9 nM
N#CCCN1CCC(n2c(C3CC3)nc3cnc4[nH]ccc4c32)CC1 CHEMBL2206061 Ki 2.9 nM
Cc1ccc(C)c(-c2nn(C)cc2NC(=O)c2cnn3ccc(N)nc23)c1 CHEMBL2178803 Ki 2.9 nM
CC1(C)CCC[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccccc3)cc12 CHEMBL3671819 IC50 2.9 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)c3ccc(Cl)cn3)CC4)n[nH]c2c1 CHEMBL3644641 IC50 2.9 nM
Clc1ccc(CNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3954454 IC50 2.9 nM
O[C@@H](CNC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1)c1ccccc1 CHEMBL3896725 IC50 2.9 nM
O=C(NC[C@@H](O)c1ccccc1)[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL4115208 IC50 2.9 nM
N#Cc1ccc(N2CCC(Nc3cc(Nc4ccccn4)ncc3C(N)=O)CC2)nc1 CHEMBL4455068 IC50 2.9 nM
CN(c1ncnc2[nH]ccc12)N1CCCC(C(=O)NCC(F)(F)F)C1 CHEMBL5186743 IC50 2.9 nM
O=C(Nc1cn(CCN2CCNCC2=O)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3899509 Ki 2.91 nM
CN(C)CCC1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3944383 Ki 2.93 nM
O=C(Nc1sc(-c2ccc(CN3CC(F)(F)C3)cc2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3951444 Ki 2.93 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2cccc(C#N)n2)[C@H](C)C1 CHEMBL5440017 IC50 2.934 nM
O=C(Nc1cn([C@H]2CNCC[C@@H]2O)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3923446 Ki 2.94 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCCC(OCC(N)=O)C2)CC1 CHEMBL3652281 IC50 2.96 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@H](S(C)(=O)=O)C2)CC1 CHEMBL3652347 IC50 2.98 nM
CN1CCC(=CCn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3926957 Ki 2.99 nM
CC(=O)NCc1nc2cnc3[nH]ccc3c2n1C1CC2CCC1C2 CHEMBL2206637 Ki 3.0 nM
c1cc2c(ncc3[nH]nc(C4CCCCC4)c32)[nH]1 CHEMBL2322135 IC50 3.0 nM
CCc1nc(N[C@@H]2CCC[C@@H]2C#N)c2cc[nH]c(=O)c2n1 CHEMBL2436945 Ki 3.0 nM
CC(C)(N[C@@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1)C1CC1 CHEMBL3647782 IC50 3.0 nM
CNC(=O)O[C@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647874 IC50 3.0 nM
N#C[C@H]1C[C@@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C3CC3)cc2)n1 CHEMBL3647862 IC50 3.0 nM
N#C[C@H]1C[C@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)c(Cl)c2)n1 CHEMBL3702943 IC50 3.0 nM
CN(C)[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)[C@@H](C#N)C1 CHEMBL3703095 IC50 3.0 nM
CN(CC(F)F)[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3703082 IC50 3.0 nM
COC1CN([C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3640019 IC50 3.0 nM
N#C[C@H]1C[C@@H](NCC(F)(F)F)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647797 IC50 3.0 nM
N#C[C@H]1C[C@@H](NCC2CC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3702990 IC50 3.0 nM
C[C@@](O)(c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cn1)C(F)(F)F CHEMBL3699536 IC50 3.0 nM
N#C[C@H]1C[C@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)F)nc2)n1 CHEMBL3702952 IC50 3.0 nM
N#C[C@@H]1C[C@H](C(=O)NCC(F)(F)F)CCC1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647883 IC50 3.0 nM
CC(C)(O)C1CN([C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3703008 IC50 3.0 nM
N#C[C@H]1C[C@@H](C(=O)N2CCC(F)(F)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647901 IC50 3.0 nM
C[C@]1(C#N)CC[C@H](F)C[C@@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3647933 IC50 3.0 nM
N#C[C@H]1C[C@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)nc2)n1 CHEMBL3702948 IC50 3.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccnnc2)n1 CHEMBL3699555 IC50 3.0 nM
CS(=O)(=O)c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3650678 IC50 3.0 nM
CN[C@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3702974 IC50 3.0 nM
N#C[C@H]1C[C@@H](C(=O)N2CC(F)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647907 IC50 3.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(CN)cc2)n1 CHEMBL3699546 IC50 3.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(F)nc2)n1 CHEMBL3699520 IC50 3.0 nM
CN(c1ncnc2[nH]ccc12)[C@H]1C[C@@H](NS(=O)(=O)c2cc(C#N)ccn2)C1 CHEMBL3655089 IC50 3.0 nM
COC(=O)c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cn1 CHEMBL3702891 IC50 3.0 nM
N#C[C@H]1C[C@@H](N2CC(F)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3703074 IC50 3.0 nM
CS(=O)(=O)C1CN(C(=O)[C@@H]2CC[C@@H](n3cc(C(N)=O)c(Nc4ccc(Cl)cc4)n3)[C@H](C#N)C2)C1 CHEMBL3647881 IC50 3.0 nM
N#C[C@@H]1C[C@H](C(=O)N2CC(F)(F)C2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647888 IC50 3.0 nM
N#C[C@H]1C[C@H](NCCC(F)(F)F)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647740 IC50 3.0 nM
C[C@H]1C[C@H](C)N1[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3703001 IC50 3.0 nM
C[C@@]1(O)CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3647843 IC50 3.0 nM
CC(C)(c1ccc(Nc2nn([C@@H]3CCCC[C@H]3C#N)cc2C(N)=O)cc1)[C@H](O)C(F)(F)F CHEMBL3699529 IC50 3.0 nM
[C-]#[N+][C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccccc2)n1 CHEMBL3699463 IC50 3.0 nM
N#C[C@@H]1CCCC[C@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)nc2)n1 CHEMBL3699545 IC50 3.0 nM
N#C[C@@H]1CCCC[C@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)Nc3ccccn3)cc2)n1 CHEMBL3702888 IC50 3.0 nM
N#C[C@H]1C[C@@H](NCC(F)F)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccnc(F)c2)n1 CHEMBL3703083 IC50 3.0 nM
Cn1cc(-c2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)cc3C(N)=O)ccn2)cn1 CHEMBL3699523 IC50 3.0 nM
C=C[C@]1(O)CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3647836 IC50 3.0 nM
CNC(=O)c1c[nH]c(-c2c(N[C@H]3CC[C@@H](N)CC3)cc[nH]c2=O)n1 CHEMBL3781767 IC50 3.0 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(Cc3cccc(OC)c3)C4)n[nH]c2c1 CHEMBL3644635 IC50 3.0 nM
FC(F)[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3929124 IC50 3.0 nM
CC(C)(C)OC(=O)C1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1 CHEMBL3939566 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2cccc(OCCO)n2)CC1 CHEMBL3960729 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2cccc(C#N)n2)CC1 CHEMBL3889521 IC50 3.0 nM
CCOc1ccc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)cn1 CHEMBL3920283 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2cc(F)cc(F)c2)CC1 CHEMBL3917536 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2ccncc2)CC1 CHEMBL3892955 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2cccc(CF)n2)CC1 CHEMBL3911273 IC50 3.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cnc(C#N)nc3)n2)CC1 CHEMBL3962429 IC50 3.0 nM
Cn1ccc(-c2ccc(Nc3nn(C4(CC#N)CCN(C(=O)OC(C)(C)C)CC4)cc3C(N)=O)cc2)n1 CHEMBL3926301 IC50 3.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccncn3)n2)CC1 CHEMBL3927070 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(Cc2cccnc2)CC1 CHEMBL3933191 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(Cc2ccccc2Cl)CC1 CHEMBL3918828 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(Cc2ccc(Cl)cc2F)CC1 CHEMBL3946164 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ccn[nH]2)CC1 CHEMBL3948522 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ncco2)CC1 CHEMBL3957604 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(Cc2cccc(F)n2)CC1 CHEMBL3920671 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)OCc2ccccc2)CC1 CHEMBL3920087 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(C(=O)OC2CCOCC2)CC1 CHEMBL3943646 IC50 3.0 nM
CC(C)COC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1 CHEMBL3972281 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)OC2Cc3ccccc3C2)CC1 CHEMBL3976529 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)OC2CCOCC2)CC1 CHEMBL3908726 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)OCCC(F)(F)F)CC1 CHEMBL3963750 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)OC2CCOCC2)CC1 CHEMBL3977249 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CN(C(=O)OC2CCCC2)C1 CHEMBL4109140 IC50 3.0 nM
CC(CF)(CF)C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1 CHEMBL3907611 IC50 3.0 nM
COCC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1 CHEMBL3927869 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3cncc(F)c3)n2)CCN(C(=O)CC(F)(F)F)CC1 CHEMBL3947600 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(S(=O)(=O)c2ccccc2Cl)CC1 CHEMBL3979025 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(S(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1 CHEMBL3908689 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CN(C(=O)Nc2cccc(F)c2)C1 CHEMBL4111876 IC50 3.0 nM
N#CCC1(C2C=C(C(N)=O)C(Nc3ccnc(F)c3)=N2)CCC(N2CCC(O)CC2)CC1 CHEMBL3986677 IC50 3.0 nM
CCOC(=O)COC(=O)N1CC[C@@H](n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)[C@H](C#N)C1 CHEMBL4110556 IC50 3.0 nM
N#C[C@@H]1CCN(C(=O)OCC2CC2)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3977697 IC50 3.0 nM
N#C[C@@H]1CCN(C(=O)OC2COC2)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3902593 IC50 3.0 nM
N#C[C@@H]1CN(Cc2ccon2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL4109645 IC50 3.0 nM
N#C[C@@H]1CCOC[C@H]1n1cc(C(N)=O)c(Nc2ccc([C@@H](O)C(F)(F)F)cc2)n1 CHEMBL3899281 IC50 3.0 nM
C[C@](O)(c1ccc(Nc2nn([C@@H]3COCC[C@H]3C#N)cc2C(N)=O)cc1)C(F)F CHEMBL3947292 IC50 3.0 nM
COC(C)(C)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL4110650 IC50 3.0 nM
N#C[C@H]1CS(=O)(=O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3893456 IC50 3.0 nM
CN(c1nc(Nc2cnn(C)c2)ncc1Cl)C1CCC2(CCCN(C(=O)CC#N)C2)C1 CHEMBL3931866 IC50 3.0 nM
CC(=O)N1CC2CC(Nc3nc(Nc4cnn(C)c4)ncc3Cl)CC2C1 CHEMBL3944988 IC50 3.0 nM
Cn1cnc(Nc2ncc(Cl)c(NC3CCC4(CC3)CCN(C(=O)CC#N)CC4)n2)c1 CHEMBL3977733 IC50 3.0 nM
CC(C)n1cc(-c2cn3ncc(C(N)=O)c(N[C@@H]4CN(C(=O)C5(C#N)CC5)C[C@@H]4CF)c3n2)cn1 CHEMBL3891603 IC50 3.0 nM
CC[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cn[nH]c3)nc12 CHEMBL3935662 IC50 3.0 nM
CN1CN([C@H]2CC[C@H](CF)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3936358 IC50 3.0 nM
CN(c1ncnc2[nH]ccc12)[C@H]1C[C@@H](NS(=O)(=O)c2ccc(F)cc2)C1 CHEMBL4103698 IC50 3.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccccc2)n1 CHEMBL4076821 IC50 3.0 nM
Cc1[nH]nc2[nH]c(=O)cc([C@H]3CC[C@H](CC(=O)N4CC(Cc5ccccc5)C4)CC3)c12 CHEMBL4649484 IC50 3.0 nM
O=C(Nc1nc2cccc(C3CCC(NC(=O)C4CC4(F)F)CC3)n2n1)C1CC1 CHEMBL5200989 IC50 3.0 nM
O=C(Nc1nc2cccc(C3CCC4(CC3)CCN(C(=O)[C@@H]3CC3(F)F)CC4)n2n1)C1CC1 CHEMBL5191228 IC50 3.0 nM
O=C(Nc1nc2cccc(C3CCC4(CC3)CN(C(=O)[C@@H]3CC3(F)F)C4)n2n1)C1CC1 CHEMBL5172397 IC50 3.0 nM
Cc1cc(Nc2ncc(C)c(-c3cnn(CCC#N)c3)n2)sn1 CHEMBL5423027 IC50 3.0 nM
Cc1cc(Nc2ncc(Cl)c(-c3cnn(CCC#N)c3)n2)sn1 CHEMBL5423566 IC50 3.0 nM
COc1ccccc1Nc1cc(Nc2ccc(CC(=O)O[C@@H]3CCOC3)cn2)ncc1C(N)=O CHEMBL5407260 IC50 3.0 nM
CNC(=O)CCN1CCC(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3899968 Ki 3.02 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2C[C@H](CO)[C@@H](F)C2)CC1 CHEMBL3652351 IC50 3.03 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(CCCCc3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3974692 Ki 3.04 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC(S(=O)(=O)c3ccccc3)C2)CC1 CHEMBL3652384 IC50 3.05 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@@H](CO)C2)CC1 CHEMBL3652303 IC50 3.06 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@H](CS(N)(=O)=O)C2)CC1 CHEMBL3652337 IC50 3.1 nM
CCC(=O)N1C[C@H]2C[C@@H](Nc3c(C(N)=O)cnn4cc(-c5ccc(F)nc5)cc34)[C@H](C)[C@H]2C1 CHEMBL3667477 IC50 3.1 nM
c1cc2c(ncn3nnc(C4CC5CCC4C5)c23)[nH]1 CHEMBL3926766 IC50 3.1 nM
Fc1cc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)ccc1C(F)(F)F CHEMBL3931226 IC50 3.1 nM
CC(C#N)[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3945399 IC50 3.1 nM
O=C(Nc1cn(CC(=O)N2CCC(CN3CCC(F)(F)CC3)(c3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3911700 Ki 3.1 nM
N#CC1(C(=O)N2C[C@H](CF)[C@H](Nc3c(C(N)=O)cnn4cc(-c5cnn(C(F)F)c5)nc34)C2)CC1 CHEMBL3973864 IC50 3.1 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@@](O)(COc3cccc(F)c3)C2)CC1 CHEMBL3652355 IC50 3.12 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2cccc(Cl)c2)[C@H](C)C1 CHEMBL4779060 IC50 3.13 nM
COC(=O)N[C@@H]1CC[C@@H](n2cnc3cnc4[nH]ccc4c32)C1 CHEMBL2152424 Ki 3.2 nM
CC(C)(C)[C@@H](NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N1CC(C#N)C1 CHEMBL2325895 IC50 3.2 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@H](O)C2)CC1 CHEMBL3652287 IC50 3.2 nM
N[C@@H]1CC[C@H](Nc2cc[nH]c(=O)c2-c2nc3ccccc3[nH]2)C1 CHEMBL3779924 IC50 3.2 nM
CS(=O)(=O)c1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3908624 IC50 3.2 nM
OC(CN[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1)(c1ccccc1)C(F)(F)F CHEMBL3963428 IC50 3.2 nM
O=C(C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1)NCC(F)(F)F CHEMBL3950137 IC50 3.2 nM
N#CCNC[C@H]1CC[C@H](N2CN(CC(F)(F)F)C(=O)c3cnc4[nH]ccc4c32)CC1 CHEMBL3968326 IC50 3.2 nM
O=C1c2cnc3[nH]ccc3c2N([C@H]2CC[C@H](CNCC(F)(F)F)CC2)CN1CC(F)(F)F CHEMBL3891913 IC50 3.2 nM
COCN1CN([C@H]2CC[C@H](CN(C)CC(F)(F)F)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3961430 IC50 3.2 nM
C[C@@H]1CCN(C(=O)Cn2cnnn2)C[C@@H]1n1c(=O)[nH]c2cnc3[nH]ccc3c21 CHEMBL5268959 IC50 3.2 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1n1ccc2cnc3[nH]cc(C#N)c3c21 CHEMBL5273533 IC50 3.2 nM
C=CCN(CCOc1ccc(C)cc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3925455 Ki 3.22 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@H](c3ncccn3)C2)CC1 CHEMBL3652358 IC50 3.27 nM
CSCCOC(=O)CNCCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3945907 Ki 3.29 nM
CS(=O)(=O)NCc1nc2cnc3[nH]ccc3c2n1C1CCCCCC1 CHEMBL2206636 Ki 3.3 nM
N#Cc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3953550 IC50 3.3 nM
c1cc2c(ncn3nnc(C4CCCCCC4)c23)[nH]1 CHEMBL3917774 IC50 3.3 nM
O=C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3967735 IC50 3.3 nM
FC(F)(F)c1ccc(CNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3900746 IC50 3.3 nM
N#Cc1cc(F)ccc1NC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3919766 IC50 3.3 nM
NC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3923184 IC50 3.3 nM
Cc1nn(C)cc1-c1cn2ncc(C(N)=O)c(N[C@H]3CN(c4ncc(C#N)cn4)C[C@H]3C)c2n1 CHEMBL3949959 IC50 3.3 nM
CCN1CN([C@H]2CC[C@H](CNCC(F)(F)F)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3936693 IC50 3.3 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccnc(F)c4)cc23)CC[C@]1(C)N CHEMBL4104127 IC50 3.3 nM
O=C(Nc1c[nH]nc1-c1ccccc1OC(F)F)c1cnn2cccnc12 CHEMBL4757212 Ki 3.3 nM
CN(c1ncnc2[nH]ccc12)N1CCC(C(=O)NCC#N)C1 CHEMBL5189213 IC50 3.3 nM
CC(C)(C)OC(=O)N1CC[C@H](n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)[C@@H](O)C1 CHEMBL3921889 Ki 3.32 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(Cl)cc2)C[C@@H]1F CHEMBL5439582 IC50 3.32 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2cccc(OC)c2)[C@@H](C)C1 CHEMBL4750779 IC50 3.36 nM
CC[C@H](C(=O)N1CC(C#N)C1)n1c(=O)c2cc(OC)c(OC)cc2c2cnc3[nH]ccc3c21 CHEMBL4286103 IC50 3.37 nM
C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1C1CCN(CCC#N)CC1 CHEMBL2386647 Ki 3.4 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)c3ccc(C#N)nc3)CC4)n[nH]c2c1 CHEMBL3644630 IC50 3.4 nM
Fc1cnccc1CN1CCC(c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3940267 IC50 3.4 nM
OC(CN[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1)c1ccccc1 CHEMBL3954819 IC50 3.4 nM
Fc1ccc(C2(NC[C@H]3CC[C@H](c4nnn5cnc6[nH]ccc6c45)CC3)CCC2)cc1 CHEMBL3959692 IC50 3.4 nM
N#CCC(=O)N(CC(F)(F)F)C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3975399 IC50 3.4 nM
N#CC1CC12CCC(c1nnn3cnc4[nH]ccc4c13)CC2 CHEMBL3962051 IC50 3.4 nM
N#CCNC[C@H]1CC[C@H](N2CN(C3CC3)C(=O)c3cnc4[nH]ccc4c32)CC1 CHEMBL3976846 IC50 3.4 nM
N#CCCCN1CN([C@H]2CC[C@H](CNCC(F)(F)F)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3981841 IC50 3.4 nM
CCN1CN([C@H]2CC[C@H](CNS(C)(=O)=O)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3949572 IC50 3.4 nM
Clc1cccc(Nc2nc(Nc3cn[nH]c3)ncc2Cl)c1 CHEMBL4453646 IC50 3.4 nM
Cc1[nH]nc2[nH]c(=O)cc([C@H]3CC[C@H](CC(=O)N4CCC(C)(C)CC4)CC3)c12 CHEMBL4636507 IC50 3.4 nM
OCCc1nc2cnc3[nH]ccc3c2n1C1CCCCC1 CHEMBL2386638 Ki 3.5 nM
C[C@H](O)CNC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3902287 IC50 3.5 nM
OC(CN[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1)(c1ccc(Cl)cc1)C(F)(F)F CHEMBL3978620 IC50 3.5 nM
N#Cc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)cc1F CHEMBL3961357 IC50 3.5 nM
OCCNC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3904312 IC50 3.5 nM
O=C1COc2ccc(NC[C@H]3CC[C@H](c4nnn5cnc6[nH]ccc6c45)CC3)cc2N1 CHEMBL3933397 IC50 3.5 nM
N#CCNS(=O)(=O)C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3896324 IC50 3.5 nM
N#CCN1CN(C2CCCCC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3892634 IC50 3.5 nM
N#CCN1CN([C@H]2CC[C@H](CO)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3952936 IC50 3.5 nM
C[C@H](c1ncc(F)cn1)n1c(=O)[nH]c2cnc(-c3cnc4ccc(F)cn34)nc21 CHEMBL4469844 IC50 3.5 nM
N#Cc1ccc(N2CCC(Nc3cc(Nc4ccncn4)ncc3C(N)=O)CC2)nc1 CHEMBL4463043 IC50 3.5 nM
Cc1cccc(C[C@H]2CCCN2S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)n1 CHEMBL3652377 IC50 3.6 nM
C[C@@H]1[C@H]2CN(C(=O)C(C)(C)O)C[C@H]2C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnc(N)nc3)cc12 CHEMBL3667470 IC50 3.6 nM
CC[C@@H]1CN(C(=O)C(C)(C)O)CC[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccnc(C)c3)cc12 CHEMBL3667483 IC50 3.6 nM
N#CCCNC(=O)[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3921442 IC50 3.6 nM
CC[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C(F)F)c3)nc12 CHEMBL3908821 IC50 3.6 nM
CN1CN([C@H]2CC[C@H](CNC3(C#N)CC3)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3932070 IC50 3.6 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccncc4F)cc23)CC[C@]1(C)N CHEMBL4079880 IC50 3.6 nM
CN(c1ncnc2[nH]ccc12)[C@@H]1CCN(S(=O)(=O)c2ccc([N+](=O)[O-])cc2)C1 CHEMBL4227132 IC50 3.6 nM
CN(C)C1CCN(C(=O)c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3918206 Ki 3.63 nM
CC(C)(C)OC(=O)N[C@H]1CC[C@@H](n2cnc3cnc4[nH]ccc4c32)C1 CHEMBL2152425 Ki 3.7 nM
CC(=O)NCCc1nc2cnc3[nH]ccc3c2n1C1CCN(CCC#N)CC1 CHEMBL2206623 Ki 3.7 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)c3ccsn3)C4)n[nH]c2c1 CHEMBL3644619 IC50 3.7 nM
Fc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)cn1 CHEMBL3965965 IC50 3.7 nM
CCCn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(C(=O)C5(C#N)CC5)C[C@H]4CF)c3n2)cn1 CHEMBL3919654 IC50 3.7 nM
N#CC1(C(=O)N2C[C@H](CF)[C@H](Nc3c(C(N)=O)cnn4cc(-c5cnn(C6CC6)c5)nc34)C2)CC1 CHEMBL3906388 IC50 3.7 nM
CNC(=O)c1nnc(NC(=O)N2CCC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC CHEMBL5419627 Kd 3.7 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@H](CC#N)C2)CC1 CHEMBL3652305 IC50 3.76 nM
O=C(Nc1cn(CC(=O)N2CCC(N(Cc3ccccc3)CC(F)(F)F)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3949479 Ki 3.76 nM
CS(=O)(=O)NCc1nc2cnc3[nH]ccc3c2n1[C@H]1C[C@@H]2CC[C@H]1C2 CHEMBL2206058 Ki 3.8 nM
C[C@]1(F)CCC[C@H]1Nc1c(C(N)=O)cnn2cc(N3CCCC3=O)cc12 CHEMBL3671794 IC50 3.8 nM
CCOc1ccc(Cl)cc1-c1nn([C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cnn2cccnc12 CHEMBL3667528 Ki 3.8 nM
c1cc2c(ncn3nnc(C4CCCCC4)c23)[nH]1 CHEMBL3969473 IC50 3.8 nM
CN(C)C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3935688 IC50 3.8 nM
CC[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)nc12 CHEMBL3963792 IC50 3.8 nM
COCN1CN([C@H]2CC[C@H](CNCC(F)(F)F)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3963389 IC50 3.8 nM
O=C(Nc1cn([C@H]2CCNC[C@@H]2O)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3896379 Ki 3.85 nM
NC(=O)c1cnc2[nH]ccc2c1N[C@@H]1[C@@H]2CC3C[C@H]1C[C@@](O)(C3)C2 CHEMBL3137308 IC50 3.9 nM
CN(C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1)c1ccc(C#N)cc1 CHEMBL3897849 IC50 3.9 nM
N#Cc1ccc(NC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3956611 IC50 3.9 nM
c1nc(CCNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)c[nH]1 CHEMBL3956418 IC50 3.9 nM
Fc1ccc(CCN[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3983447 IC50 3.9 nM
FC(F)(F)C(F)(F)CNC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3972353 IC50 3.9 nM
CCCn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(C(=O)C5(C#N)CC5)C[C@H]4CC)c3n2)cn1 CHEMBL3949368 IC50 3.9 nM
CC[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3sc(C)nc3C)nc12 CHEMBL3980209 IC50 3.9 nM
NC(=O)c1cnc2[nH]ccc2c1NC1C2CC3CC1CC(O)(C3)C2 CHEMBL4242999 IC50 3.9 nM
Cc1nc(-c2cc(Cl)ccc2OC(F)F)c(NC(=O)c2cnn3cccnc23)[nH]1 CHEMBL4764700 Ki 3.9 nM
NC(=O)c1cnc2[nH]ccc2c1NC1[C@@H]2CC3C[C@H]1CC(O)(C3)C2 CHEMBL5424861 IC50 3.9 nM
O=C(Nc1cn(CC(=O)N2CCC(N(CCc3ccccc3)CC(F)(F)F)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3910000 Ki 3.98 nM
CCc1cc(O)c(F)cc1-c1cc(NS(C)(=O)=O)c2cn[nH]c2c1 CHEMBL4539949 pIC50 3.981 nM
CCc1cc(O)c(F)cc1-c1cc(N(C)CCO)c2nc(N)ncc2c1 CHEMBL5084913 pIC50 3.981 nM
c1cc2c(ncc3ncc(C4CCCCC4)n32)[nH]1 CHEMBL2322142 IC50 4.0 nM
CC(C)(C)c1nc2c3ccc(F)cc3c3c(=O)[nH]ccc3c2[nH]1 CHEMBL21156 IC50 4.0 nM
N#C[C@H]1C[C@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccnc(F)c2)n1 CHEMBL3703071 IC50 4.0 nM
N#C[C@H]1C[C@@H](N[C@@H](C2CC2)C(F)(F)F)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3647767 IC50 4.0 nM
[C-]#[N+][C@H]1C[C@@H](N2CCC2)CC[C@@H]1n1cc(Nc2ccc(OC(F)F)nc2)c(C(N)=O)c1 CHEMBL3702983 IC50 4.0 nM
CC(C)(O)C1CN([C@H]2CCC(n3cc(C(N)=O)c(Nc4ccc(Cl)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3647784 IC50 4.0 nM
C[C@H](N[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(OC(F)(F)F)cc3)n2)[C@@H](C#N)C1)C1CC1 CHEMBL3703033 IC50 4.0 nM
N#C[C@H]1CCCCC1n1cc(C(N)=O)c(Nc2ccccc2)n1 CHEMBL3650673 IC50 4.0 nM
Cc1cc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cnc1C#N CHEMBL3702898 IC50 4.0 nM
N#C[C@H]1CC[C@H](NCc2ccccc2)C[C@@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3699483 IC50 4.0 nM
CN(CC1CC1)[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647815 IC50 4.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(F)c(F)c2)n1 CHEMBL3702921 IC50 4.0 nM
CN(c1ncnc2[nH]ccc12)[C@H]1C[C@@H](NS(=O)(=O)N2CC(C#N)C2)C1 CHEMBL3655102 IC50 4.0 nM
N#C[C@H]1C[C@@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)nc2)n1 CHEMBL3647860 IC50 4.0 nM
N#C[C@H]1C[C@@H](NC2CCOCC2)CCC1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647791 IC50 4.0 nM
N#C[C@H]1C[C@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)nc2)n1 CHEMBL3702946 IC50 4.0 nM
N#C[C@H]1C[C@@H](NCC(F)F)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)c(F)c2)n1 CHEMBL3703061 IC50 4.0 nM
Cc1noc(-c2ccc(Nc3nn([C@H]4CCCC[C@@H]4C#N)cc3C(N)=O)cc2)n1 CHEMBL3699507 IC50 4.0 nM
CN(c1ncnc2[nH]ccc12)[C@H]1C[C@@H](CS(=O)(=O)c2ccc(F)c(Cl)c2)C1 CHEMBL3658867 IC50 4.0 nM
C[C@H](N[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1)C1CC1 CHEMBL3703069 IC50 4.0 nM
N#C[C@H]1CC(NC(C2CC2)C2CC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647737 IC50 4.0 nM
N#C[C@H]1C[C@@H](NCC(F)F)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(F)c(Cl)c2)n1 CHEMBL3703039 IC50 4.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccnc(Cl)c2)n1 CHEMBL3699508 IC50 4.0 nM
N#C[C@H]1CC(F)CCC1n1cc(C(N)=O)c(Nc2ccccc2)n1 CHEMBL3702934 IC50 4.0 nM
C[C@]1(C#N)CC[C@@H](F)C[C@@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3702929 IC50 4.0 nM
CC1(N[C@H]2CCC(n3cc(C(N)=O)c(Nc4ccccc4)n3)[C@@H](C#N)C2)COC1 CHEMBL3647803 IC50 4.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2cnc3cc(Cl)ccc3c2)n1 CHEMBL3699562 IC50 4.0 nM
N#C[C@H]1C[C@@H](OCC2CC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3702967 IC50 4.0 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4cc(Cc5ccc(N6C=CC=CC6)nc5)cnc4[nH]3)n[nH]c2c1 CHEMBL3644643 IC50 4.0 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(Cc3cccnc3C#N)C4)n[nH]c2c1 CHEMBL3644638 IC50 4.0 nM
O[C@H]1CCN(C[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)C1 CHEMBL3980241 IC50 4.0 nM
O[C@H]1Cc2ccccc2[C@H]1NC1CCC(c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3889789 IC50 4.0 nM
COc1ccc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)cc1OC CHEMBL3919793 IC50 4.0 nM
COc1cc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)ccc1F CHEMBL3896885 IC50 4.0 nM
Cc1ccc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)cc1 CHEMBL3895008 IC50 4.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cn3)n2)CC1 CHEMBL3983423 IC50 4.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(Cc2ccnc3[nH]ccc23)CC1 CHEMBL3931206 IC50 4.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(Cc2ccc3[nH]ccc3c2)CC1 CHEMBL3936674 IC50 4.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(Cc2cccc3cc[nH]c23)CC1 CHEMBL3921194 IC50 4.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(CCc2ccccc2)CC1 CHEMBL3890579 IC50 4.0 nM
CC(c1ccccc1)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1 CHEMBL3974409 IC50 4.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)OCC2CCC2)CC1 CHEMBL3953266 IC50 4.0 nM
COC(C)COC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1 CHEMBL3974257 IC50 4.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)OC2CCCOC2)CC1 CHEMBL3935881 IC50 4.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)OCc2cccc(F)c2)CC1 CHEMBL3955861 IC50 4.0 nM
COCCOC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1 CHEMBL3938472 IC50 4.0 nM
COCCOC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1 CHEMBL3951407 IC50 4.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)c2cccc(Cl)c2)CC1 CHEMBL3962864 IC50 4.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(C(=O)C(C2CCC2)C(F)(F)F)CC1 CHEMBL3927968 IC50 4.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(C(=O)Cn2ccnc2)CC1 CHEMBL3896472 IC50 4.0 nM
CCCCNC(=O)N1CC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1 CHEMBL3981696 IC50 4.0 nM
Cc1cccc(NC(=O)N2CC(CC#N)(n3cc(C(N)=O)c(Nc4ccccc4)n3)C2)c1 CHEMBL4110428 IC50 4.0 nM
CC(=O)c1cccc(NC(=O)N2CC(CC#N)(n3cc(C(N)=O)c(Nc4ccccc4)n3)C2)c1 CHEMBL4107428 IC50 4.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(Nc2ccccn2)CC1 CHEMBL3892313 IC50 4.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(N)CC1 CHEMBL3909605 IC50 4.0 nM
CC(F)(F)C(=O)N1CC[C@](CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)nc3)n2)[C@@H](F)C1 CHEMBL3898012 IC50 4.0 nM
N#C[C@@H]1CN(C(=O)OCCF)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL4106649 IC50 4.0 nM
N#C[C@@H]1CCN(C(=O)OC(CF)CF)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3908927 IC50 4.0 nM
CC(C)COC(=O)N1CC[C@@H](C#N)[C@H](n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1 CHEMBL3910184 IC50 4.0 nM
N#C[C@@H]1CCN(C(=O)OCC(F)(F)F)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3983426 IC50 4.0 nM
N#C[C@@H]1CCN(C(=O)OCCN2CCOCC2)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3973945 IC50 4.0 nM
CC1(COC(=O)N2CC[C@@H](C#N)[C@H](n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)C2)COC1 CHEMBL3930581 IC50 4.0 nM
N#C[C@@H]1CCN(Cc2cc(F)ccn2)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3897711 IC50 4.0 nM
Cc1cc(CN2CC[C@@H](C#N)[C@H](n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)C2)no1 CHEMBL3986662 IC50 4.0 nM
N#C[C@@H]1CN(Cc2ccn[nH]2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL4114576 IC50 4.0 nM
CC1=NOC(CN2CC[C@@H](n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)[C@H](C#N)C2)C1 CHEMBL4106905 IC50 4.0 nM
N#C[C@@H]1CCOC[C@H]1n1cc(C(N)=O)c(Nc2ccc([C@H](O)C(F)(F)F)cc2)n1 CHEMBL3900421 IC50 4.0 nM
Cn1cc(Nc2ncc(Cl)c(NC3CCC4(CC3)CCN(c3ccc(C#N)cn3)CC4)n2)cn1 CHEMBL3902637 IC50 4.0 nM
Cc1cnc(Nc2cnn(C)c2)nc1NC1CC2CN(S(C)(=O)=O)CC2C1 CHEMBL3956624 IC50 4.0 nM
CCn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(c5ccc(C#N)cn5)C[C@H]4C)c3n2)cn1 CHEMBL3900587 IC50 4.0 nM
Cn1cc(-c2cn3ncc(C(N)=O)c(N[C@@H]4CN(C(=O)C5(C#N)CC5)C[C@@H]4CF)c3n2)cn1 CHEMBL3904090 IC50 4.0 nM
CCOc1ccc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)cn1 CHEMBL4091096 IC50 4.0 nM
N#CC(C#N)=Cc1ccc(-c2nc3cnc4[nH]ccc4c3n2C2CCCCC2)o1 CHEMBL4125719 IC50 4.0 nM
Cc1cnc(Nc2cc(N3CCOCC3)cc(N3CCOCC3)c2)nc1Nc1cccc(CO)c1 CHEMBL4165758 IC50 4.0 nM
NC(=O)c1cnc2[nH]ccc2c1NC1C2CC3CC1CC(C2)C3O CHEMBL4446102 IC50 4.0 nM
COc1nn(C)cc1Nc1ncc(C)c(-c2c[nH]c3c(NCc4ccc(C)nc4C)cccc23)n1 CHEMBL4446962 IC50 4.0 nM
Cc1cc(Nc2cc3ncccc3c(N[C@H]3CC[C@@H]4C[C@H](C3)N4CCC#N)n2)n[nH]1 CHEMBL4782814 IC50 4.0 nM
Cc1cnc(Nc2ccc([N+](=O)[O-])cc2)nc1N1CCC2(CCNC2=O)CC1 CHEMBL5075663 IC50 4.0 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC(COCC3CC3)CC2)CC1 CHEMBL3652328 IC50 4.07 nM
N#Cc1ccc(N2CC[C@@H](Nc3c(C(N)=O)cnc4[nH]ccc34)[C@@H](F)C2)nc1 CHEMBL3593777 IC50 4.1 nM
COc1cncc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)c1 CHEMBL3671815 IC50 4.1 nM
F[C@H]1CCN(C[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)C1 CHEMBL3895546 IC50 4.1 nM
N#Cc1ccc(CN[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3903790 IC50 4.1 nM
O[C@H](CN[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1)c1ccccc1 CHEMBL4109603 IC50 4.1 nM
N#CCC(=O)NC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3981393 IC50 4.1 nM
CN(C[C@H]1CC[C@H](N2CN(C3CC3)C(=O)c3cnc4[nH]ccc4c32)CC1)S(C)(=O)=O CHEMBL3898972 IC50 4.1 nM
CN(c1ncnc2[nH]ccc12)[C@@H]1CCN(S(=O)(=O)c2cccc(C#N)c2)C1 CHEMBL4226840 IC50 4.1 nM
O=C(O)CN(CCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1)Cc1cccnc1 CHEMBL3980934 Ki 4.15 nM
CCc1cc(O)c(F)cc1-c1cc(NS(=O)(=O)CC)c2cn[nH]c2c1 CHEMBL4483364 pIC50 4.169 nM
CS(=O)(=O)NCc1nc2cnc3[nH]ccc3c2n1[C@@H]1CCC[C@@H](O)C1 CHEMBL2206628 Ki 4.2 nM
Clc1cnc2nc1NCc1cccc(c1)OCCCc1cccc(c1)N2 CHEMBL3694581 IC50 4.2 nM
COc1ccc(C#N)cc1-c1nn(Cc2nncn2C)cc1NC(=O)c1cnn2cccnc12 CHEMBL3667517 Ki 4.2 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(Cc3ccc5ncccc5c3)C4)n[nH]c2c1 CHEMBL3644631 IC50 4.2 nM
CC1CCCCC1c1nnn2cnc3[nH]ccc3c12 CHEMBL3936356 IC50 4.2 nM
N#CCNC(=O)[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3981542 IC50 4.2 nM
CCn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(C(=O)C5(C#N)CC5)C[C@H]4C)c3n2)cn1 CHEMBL3950992 IC50 4.2 nM
C[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC(C)(C)O)c3)nc12 CHEMBL3958864 IC50 4.2 nM
CC(C)n1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(C(=O)C5(C#N)CC5)C[C@H]4C)c3n2)cn1 CHEMBL3968963 IC50 4.2 nM
CC[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)nc12 CHEMBL3952907 IC50 4.2 nM
CCN1CN([C@H]2CC[C@H](CNS(=O)(=O)C3CC3)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3913622 IC50 4.2 nM
Cc1nccc(Nc2cc(NC3CCN(c4ccc(C#N)cc4)CC3)c(C(N)=O)cn2)n1 CHEMBL4463436 IC50 4.2 nM
COc1cc2c(=O)n(C3CCCCC3)c3c4cc[nH]c4ncc3c2cc1OC CHEMBL4295151 IC50 4.23 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@@H](O)[C@H](O)C2)CC1 CHEMBL3652285 IC50 4.28 nM
N#CCCN1CCC(n2c(C3CCC3)nc3cnc4[nH]ccc4c32)CC1 CHEMBL2206611 Ki 4.3 nM
COc1ccc(-c2cc3c(N[C@@H]4CC[C@](C)(NS(C)(=O)=O)C4(C)C)c(C(N)=O)cnn3c2)cn1 CHEMBL3671827 IC50 4.3 nM
NC(=O)c1cnn2cc(-c3ccc4scnc4c3)cc2c1NC12CC3CC(O)(CC(O)(C3)C1)C2 CHEMBL3671818 IC50 4.3 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(Cc3ccc(O)cc3)C4)n[nH]c2c1 CHEMBL3644632 IC50 4.3 nM
CCNC(=O)c1ccc(-c2cc3c(N[C@@H]4CN(C(=O)C(C)(C)C#N)C[C@@H]4CC)c(C(N)=O)cnn3c2)cn1 CHEMBL3672461 IC50 4.3 nM
FC(F)(F)c1ccc(CN[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3980979 IC50 4.3 nM
c1csc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)c1 CHEMBL3951230 IC50 4.3 nM
Clc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)c(Cl)n1 CHEMBL3936877 IC50 4.3 nM
O=C(O)C1CN(C[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)C1 CHEMBL3967880 IC50 4.3 nM
O=C(CC(F)(F)F)N(CC(F)(F)F)C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3924572 IC50 4.3 nM
CN(C)S(=O)(=O)C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3956450 IC50 4.3 nM
C[C@H](O)Cn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(c5ccc(C#N)cn5)C[C@H]4C)c3n2)cn1 CHEMBL3899852 IC50 4.3 nM
CC[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3c(C)nn(C)c3C)nc12 CHEMBL3905704 IC50 4.3 nM
COc1ccc(Cl)cc1-c1nn(C)cc1NC(=O)c1cncc2cn(C)nc12 CHEMBL4781423 Ki 4.3 nM
CCc1cc(O)c(F)cc1-c1cc(NS(=O)(=O)N(C)C)c2cn[nH]c2c1 CHEMBL4534573 pIC50 4.365 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@H](OCC(=O)N3CCCC3)C2)CC1 CHEMBL3652369 IC50 4.37 nM
COc1ccc(Cl)cc1-c1c(NC(=O)c2cnn3cccnc23)cnn1CCO CHEMBL3667515 Ki 4.4 nM
COc1ccc(-c2cc3c(N[C@@H]4CCN(C(=O)C(N)=O)CC4(C)C)c(C(N)=O)cnn3c2)cn1 CHEMBL3667466 IC50 4.4 nM
Fc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)c(Cl)c1 CHEMBL3925854 IC50 4.4 nM
OCCN(Cc1ccccc1)C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3965307 IC50 4.4 nM
CC[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3ccc4c(cnn4C)c3)nc12 CHEMBL3973287 IC50 4.4 nM
N#CCN1CN([C@H]2CC[C@H](CF)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3985528 IC50 4.4 nM
COc1ccccc1CS(=O)(=O)[C@H]1CCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 CHEMBL3652360 IC50 4.45 nM
N#CCCN[C@H]1CC[C@H](n2cnc3cnc4[nH]ccc4c32)CC1 CHEMBL2152420 Ki 4.5 nM
Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](NS(C)(=O)=O)CC1 CHEMBL2159206 Ki 4.5 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)c3ccc(F)cc3)CC4)n[nH]c2c1 CHEMBL3644624 IC50 4.5 nM
CC[C@@H]1CN(C(=O)[C@H](C)O)CC[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccnc(OC)c3)cc12 CHEMBL3667484 IC50 4.5 nM
N#Cc1ccc(CN2CCC(c3nnn4cnc5[nH]cc(Cl)c5c34)CC2)cc1 CHEMBL3954249 IC50 4.5 nM
CN(C)C[C@@H]1CCCN1C(=O)Cn1cc(NC(=O)c2c(N)nn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3954699 Ki 4.54 nM
CCCc1nc2cnc3[nH]ccc3c2n1C1CCN(CCC#N)CC1 CHEMBL2206060 Ki 4.6 nM
CC[C@@H](NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(Cl)ccc34)nc12)C(=O)N1CC(C#N)C1 CHEMBL2376153 IC50 4.6 nM
CNc1nc(N[C@@H]2CCC[C@@H]2C#N)c2cc[nH]c(=O)c2n1 CHEMBL2436939 Ki 4.6 nM
Cc1ncc(S(=O)(=O)N[C@H]2C[C@@H](N(C)c3ncnc4[nH]ccc34)C2)s1 CHEMBL3658869 IC50 4.6 nM
FC(F)(F)Sc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3912192 IC50 4.6 nM
O=C1COc2cc(NC[C@H]3CC[C@H](c4nnn5cnc6[nH]ccc6c45)CC3)ccc2N1 CHEMBL3909024 IC50 4.6 nM
O=C(Nc1cn([C@@H]2CNCC[C@H]2O)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL4115622 Ki 4.69 nM
CC(C)CC(=O)N[C@H]1CC[C@H](n2nnc3cnc4[nH]ccc4c32)CC1 CHEMBL2392484 Ki 4.7 nM
CS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL3645121 Kd 4.7 nM
CNC(=O)c1ccc(-c2cc3c(N[C@@H]4CN(C(=O)OC)C[C@@H]4C)c(C(N)=O)cnn3c2)cn1 CHEMBL3672457 IC50 4.7 nM
FC(F)(F)[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3900224 IC50 4.7 nM
N#CCCNC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3894474 IC50 4.7 nM
N#Cc1ccc(CN2CCC(c3ncn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3960910 IC50 4.7 nM
N#Cc1ccc(NC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1C#N CHEMBL3969516 IC50 4.7 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@H]2CN2CCCC2)CC1 CHEMBL3652379 IC50 4.73 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@H](S(=O)(=O)CCc3ccccc3)C2)CC1 CHEMBL3652354 IC50 4.79 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 4.8 nM
Cc1nc2cnc3[nH]ccc3c2n1[C@@H]1CC[C@@H](O)C1 CHEMBL2159214 Ki 4.8 nM
COc1ncc(C#N)cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12 CHEMBL3667518 Ki 4.8 nM
CC(=O)N[C@@H]1CCN(C[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)C1 CHEMBL4112922 IC50 4.8 nM
CNC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3948921 IC50 4.8 nM
N#CC(C#N)=C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3898818 IC50 4.8 nM
O=C(CCCCCn1cc(Nc2ncc(Cl)c(Nc3ccc(Cl)cc3)n2)cn1)NO CHEMBL4526274 IC50 4.8 nM
CCN(CC)C(=O)CO[C@@H]1CCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 CHEMBL3652372 IC50 4.86 nM
CO[C@H]1CC[C@H](n2c([C@@H](C)O)nc3cnc4[nH]ccc4c32)CC1 CHEMBL2386628 Ki 4.9 nM
COc1ccc(-c2nc3c(NCC4CCNCC4)c(Cl)cnc3[nH]2)cc1OC CHEMBL3747305 IC50 4.9 nM
N#Cc1cccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)c1 CHEMBL3892138 IC50 4.9 nM
FC(F)(F)c1cccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)c1 CHEMBL3936616 IC50 4.9 nM
c1cc2c(ncn3nnc(C4CCN(Cc5cncs5)CC4)c23)[nH]1 CHEMBL3983078 IC50 4.9 nM
Fc1ccc(CNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1C(F)(F)F CHEMBL3950680 IC50 4.9 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccncc4)cc23)CC[C@]1(C)N CHEMBL4063870 IC50 4.9 nM
CS(=O)(=O)NCc1nc2cnc3[nH]ccc3c2n1C1CCN(CC(F)(F)F)CC1 CHEMBL2206626 Ki 5.0 nM
N#C[C@H]1C[C@@H](NC2(C(F)(F)F)CC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647799 IC50 5.0 nM
N#C[C@H]1C[C@@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3647851 IC50 5.0 nM
CN(C)[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(OC(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3703032 IC50 5.0 nM
C[C@H]1C[C@H](C)N1[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3703000 IC50 5.0 nM
N#C[C@@H]1C(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCC[C@@H]1O CHEMBL3699473 IC50 5.0 nM
C[C@H](N[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)nc3)n2)[C@@H](C#N)C1)C1CC1 CHEMBL3702988 IC50 5.0 nM
C[C@H](N[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(OC(F)F)nc3)n2)[C@@H](C#N)C1)C1CC1 CHEMBL3703011 IC50 5.0 nM
CS(=O)(=O)c1ccc(Nc2nn([C@H]3CCC[C@H]3C#N)cc2C(N)=O)cc1 CHEMBL3699462 IC50 5.0 nM
CN(c1ncnc2[nH]ccc12)[C@H]1C[C@@H](NS(=O)(=O)C2CC(F)(F)C2)C1 CHEMBL3655094 IC50 5.0 nM
N#C[C@H]1C[C@H](O)CCC1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3699479 IC50 5.0 nM
CN(c1ncnc2[nH]ccc12)[C@H]1C[C@@H](NS(=O)(=O)N2CC[C@@H](C#N)C2)C1 CHEMBL3655098 IC50 5.0 nM
N#C[C@H]1C[C@@H](OC(=O)NC2CCCCC2)CCC1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3647867 IC50 5.0 nM
N#C[C@@H]1C[C@H](C(=O)N2CCC(F)(F)C2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647905 IC50 5.0 nM
N#C[C@H]1C[C@H](NC2CC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3647717 IC50 5.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)Nc3ccc4cccnc4c3)cc2)n1 CHEMBL3702915 IC50 5.0 nM
N#C[C@@H]1CC2(CCC1n1cc(C(N)=O)c(Nc3ccnc(F)c3)n1)CC2 CHEMBL3699495 IC50 5.0 nM
[C-]#[N+][C@H]1C[C@H](N2CCC2)CC[C@@H]1n1cc(Nc2ccc(OC(F)F)nc2)c(C(N)=O)c1 CHEMBL3650675 IC50 5.0 nM
C[C@@]1(O)CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)c(F)c3)n2)[C@@H](C#N)C1 CHEMBL3647837 IC50 5.0 nM
CN(c1ncnc2[nH]ccc12)[C@H]1C[C@@H](CS(=O)(=O)CC2CC(F)(F)C2)C1 CHEMBL3658863 IC50 5.0 nM
N#C[C@@H]1C[C@H](C(=O)NC2COC2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647886 IC50 5.0 nM
CN(c1ncnc2[nH]ccc12)[C@H]1C[C@@H](CS(=O)(=O)N2CC[C@@H](C#N)C2)C1 CHEMBL3658858 IC50 5.0 nM
N#C[C@H]1CCCC(F)[C@@H]1n1cc(C(N)=O)c(Nc2ccccc2)n1 CHEMBL3702935 IC50 5.0 nM
CC1(O)CN(C(=O)[C@@H]2CC[C@@H](n3cc(C(N)=O)c(Nc4ccc(Cl)cc4)n3)[C@H](C#N)C2)C1 CHEMBL3647900 IC50 5.0 nM
N#C[C@@H]1C[C@H](C(=O)NC2CC2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647892 IC50 5.0 nM
O=C(Nc1ccccc1)N1CCC(Nc2cc[nH]c(=O)c2-c2nc3ccccc3[nH]2)CC1 CHEMBL3781791 IC50 5.0 nM
O=c1[nH]ccc(NC2CCN(Cc3ccccc3)CC2)c1-c1nc2ccccc2[nH]1 CHEMBL3780485 IC50 5.0 nM
Cc1cc(C#N)ccc1NC1CCC(c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3913397 IC50 5.0 nM
FC(F)C(F)(F)Oc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3906687 IC50 5.0 nM
O=C(NCCc1ccc(Cl)cc1)[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3906986 IC50 5.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2ccnc3ccccc23)CC1 CHEMBL3896341 IC50 5.0 nM
Cc1cccc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)n1 CHEMBL3980404 IC50 5.0 nM
Cc1ccc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)cc1F CHEMBL3976446 IC50 5.0 nM
CC(C)(O)Cc1cccc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)n1 CHEMBL3948006 IC50 5.0 nM
Cc1cc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)ncn1 CHEMBL3954311 IC50 5.0 nM
CC1(C)CC(CN2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccnc(F)c4)n3)CC2)CCO1 CHEMBL3965488 IC50 5.0 nM
Cc1cnc(F)c(CN2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)c1 CHEMBL3915170 IC50 5.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)OCC2CCOC2)CC1 CHEMBL3953411 IC50 5.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CN(C(=O)OC2CCOC2)C1 CHEMBL4107353 IC50 5.0 nM
COCC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1 CHEMBL3945721 IC50 5.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)C2CCCO2)CC1 CHEMBL3893763 IC50 5.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)CN2CCCC2=O)CC1 CHEMBL3925830 IC50 5.0 nM
N#CCC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1 CHEMBL3976884 IC50 5.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(S(=O)(=O)c2ccc(-c3ccccc3)cc2)CC1 CHEMBL3899765 IC50 5.0 nM
CC(C)c1ccc(NC(=O)N2CC(CC#N)(n3cc(C(N)=O)c(Nc4ccccc4)n3)C2)cc1 CHEMBL4108781 IC50 5.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CN(C(=O)Nc2cc(F)ccc2F)C1 CHEMBL4107770 IC50 5.0 nM
Cc1cccc(Cl)c1NC(=O)N1CC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1 CHEMBL4107621 IC50 5.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(N2CCc3ccccc32)CC1 CHEMBL3960243 IC50 5.0 nM
CN(CCc1ccccc1)C1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3907485 Ki 5.0 nM
CC(C)(C)OC(=O)N1CC[C@H](C#N)[C@@H](n2cc(C(N)=O)c(Nc3ccccc3)n2)C1 CHEMBL4107397 IC50 5.0 nM
N#C[C@@H]1CN(C(=O)OCC(F)(F)CO)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL4114652 IC50 5.0 nM
CC1(COC(=O)N2CC[C@@H](C#N)[C@H](n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)C2)CC1 CHEMBL3979242 IC50 5.0 nM
CCOC(=O)N1CC[C@@H](C#N)[C@H](n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1 CHEMBL3894591 IC50 5.0 nM
N#C[C@@H]1CCN(CC2CCC2)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3981489 IC50 5.0 nM
N#C[C@@H]1CN(Cc2cscn2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL4112766 IC50 5.0 nM
N#C[C@@H]1CN(Cc2ncco2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL4114100 IC50 5.0 nM
N#C[C@@H]1CN(Cc2cccnc2F)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL4113820 IC50 5.0 nM
Cc1ncc(CN2CC[C@@H](n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)[C@H](C#N)C2)s1 CHEMBL4111745 IC50 5.0 nM
N#C[C@@H]1CN(CC2CCC2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL4114032 IC50 5.0 nM
N#C[C@H]1CS(=O)(=O)C[C@H]1n1cc(C(N)=O)c(Nc2ccnc(F)c2)n1 CHEMBL3909589 IC50 5.0 nM
N#C[C@@H]1CCOC[C@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3939984 IC50 5.0 nM
C[C@@H]1C[C@H](C#N)[C@@H](n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CO1 CHEMBL4114981 IC50 5.0 nM
Cc1cc(Nc2ncc(Cl)c(NC3CCC4(CC3)CCN(C(=O)CC#N)CC4)n2)nn1C CHEMBL3934227 IC50 5.0 nM
Cc1cc(Nc2ncc(Cl)c(NC3CC4CN(C(=O)CC#N)CC4C3)n2)nn1C CHEMBL3892350 IC50 5.0 nM
Cn1nc(C2CC2)cc1Nc1ncc(Cl)c(NC2CC3CN(C(=O)CC#N)CC3C2)n1 CHEMBL3971751 IC50 5.0 nM
Cc1cnc(Nc2cnn(C)c2)nc1NC1CC2CN(C(=O)CC#N)CC2C1 CHEMBL3977358 IC50 5.0 nM
CC[C@@H]1CN(C(=O)C2(C#N)CCC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)nc12 CHEMBL4115596 IC50 5.0 nM
CCN1CN([C@H]2CC[C@H](CNCC#N)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3944182 IC50 5.0 nM
CN1CN([C@H]2CC[C@H](C(F)F)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3964946 IC50 5.0 nM
COCCN1CN([C@H]2CC[C@H](CNCC(F)(F)F)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3981038 IC50 5.0 nM
CN(C[C@H]1CC[C@H](N2CN(CC(F)(F)F)C(=O)c3cnc4[nH]ccc4c32)CC1)S(C)(=O)=O CHEMBL3892991 IC50 5.0 nM
CN(CC1CC1)S(=O)(=O)C[C@H]1C[C@@H](N(C)c2ncnc3[nH]ccc23)C1 CHEMBL4093955 IC50 5.0 nM
Cc1cnc(Nc2cc(N3C[C@@H](C)N[C@@H](C)C3)cc(S(C)(=O)=O)c2)nc1Nc1cccc(CO)c1 CHEMBL4173835 IC50 5.0 nM
C[C@]1(NC#N)CCc2ccc(-c3ncnc4[nH]ccc34)cc21 CHEMBL4279720 IC50 5.0 nM
C[C@@H](O)[C@@H](CO)Nc1c(C(N)=O)cnn2cc(-c3ccccc3)cc12 CHEMBL4447360 IC50 5.0 nM
N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCC(N5CCC6(CCCO6)CC5)CC4)cc3)n2)cc1 CHEMBL5169511 IC50 5.0 nM
CC[C@@H]1CN(C(=O)NCC(F)(F)F)C[C@@H]1Nc1c(C(F)(F)F)cnc2[nH]ccc12 CHEMBL5430816 IC50 5.0 nM
COC[C@@H](C)OC(=O)Cc1ccc(Nc2cc(Nc3ccccc3OC)c(C(N)=O)cn2)nc1 CHEMBL5404574 IC50 5.0 nM
COc1ccccc1Nc1cc(Nc2ccc(CC(=O)O)cn2)ncc1C(N)=O CHEMBL5407329 IC50 5.0 nM
COc1ccccc1Nc1cc(Nc2ccc(CC(=O)O[C@H]3CCOC3)cn2)ncc1C(N)=O CHEMBL5396554 IC50 5.0 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2cccc(Cl)c2)C[C@@H]1F CHEMBL5434116 IC50 5.0 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@@H](C)CO)c2nc(NCCCN(C)C)ncc2c1 CHEMBL5076101 pIC50 5.012 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@@H](C)CO)c2nc(NCCOCCN(C)C)ncc2c1 CHEMBL5094089 pIC50 5.012 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC(O)(c3ccccc3)CC2)CC1 CHEMBL3652297 IC50 5.03 nM
CCOC(=O)CN(CCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1)Cc1cccnc1 CHEMBL3910888 Ki 5.04 nM
CN(Cc1ccccc1)C1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3892543 Ki 5.05 nM
O=C(N[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1)OCc1ccccc1 CHEMBL3927827 IC50 5.1 nM
Fc1ccc(C2(NC[C@H]3CC[C@H](c4nnn5cnc6[nH]ccc6c45)CC3)CC2)cc1 CHEMBL3889588 IC50 5.1 nM
O=C(NCC(O)(c1ccccc1)C(F)(F)F)[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3921202 IC50 5.1 nM
Cc1cnc(Nc2ccc(N3CCOCC3)cc2)nc1-c1cc2c(o1)CCN(C(=O)CC#N)C2 CHEMBL4590082 IC50 5.1 nM
CCCS(=O)(=O)N[C@H]1C[C@@H](N(C)c2ncnc3[nH]ccc23)C1 CHEMBL3655081 IC50 5.1 nM
C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@@H]1CCCN(C(=O)CC#N)C1 CHEMBL2386649 Ki 5.2 nM
N#Cc1ccc(CCNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3911362 IC50 5.2 nM
N#CCC(=O)N(CC#N)C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3904571 IC50 5.2 nM
O=C1c2cnc3[nH]ccc3c2N([C@H]2CC[C@H](CNCC(F)(F)F)CC2)CN1CC1CC1 CHEMBL3944237 IC50 5.2 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2C[C@@H](O)[C@H](c3ccccc3)C2)CC1 CHEMBL3652302 IC50 5.22 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(C#N)cn2)[C@H](C)C1 CHEMBL5430795 IC50 5.26 nM
C[C@@H]1C[C@@H](CS(=O)(=O)N2CCC[C@H](O)C2)CC[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL3652400 IC50 5.28 nM
COc1cc2c(=O)n([C@@H]3CCCNC3)c3c4cc[nH]c4ncc3c2cc1OC CHEMBL4287893 IC50 5.28 nM
CS(=O)(=O)NCc1nc2cnc3[nH]ccc3c2n1C1CCCC1 CHEMBL2206635 Ki 5.3 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCCC(F)C2)CC1 CHEMBL3652283 IC50 5.3 nM
Clc1cc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)ccn1 CHEMBL3957659 IC50 5.3 nM
Fc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)cc1F CHEMBL3953486 IC50 5.3 nM
c1ccc(CNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3967397 IC50 5.3 nM
c1cc[n+]2cc(CN3CCC(c4nnn5cnc6[nH]ccc6c45)CC3)sc2c1 CHEMBL4115251 IC50 5.3 nM
N#CCN1CCC(c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3902123 IC50 5.3 nM
CC1CC1NC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3892159 IC50 5.3 nM
N#C/C=C/[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3971373 IC50 5.3 nM
C[C@@H]1CN(c2ccc(C#N)cn2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC(C)(C)O)c3)nc12 CHEMBL3973511 IC50 5.3 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2C[C@@H](O)[C@H](C#N)C2)CC1 CHEMBL3652309 IC50 5.35 nM
NC[C@@H]1CCCN1C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3927987 Ki 5.35 nM
Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@@H](O)C1 CHEMBL2159215 Ki 5.4 nM
CC(C)CS(=O)(=O)NCc1nc2cnc3[nH]ccc3c2n1C1CCN(CCC#N)CC1 CHEMBL2206622 Ki 5.4 nM
C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](O)CC1 CHEMBL2386625 Ki 5.4 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4cccc5ncccc45)cc23)CC[C@]1(C)N CHEMBL3671812 IC50 5.4 nM
FC(F)(F)Oc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3918854 IC50 5.4 nM
Fc1ccc(NC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3983231 IC50 5.4 nM
Cc1ccc(CNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)o1 CHEMBL3948691 IC50 5.4 nM
Clc1ccc(CN[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3904756 IC50 5.4 nM
OC(CN1CCC(c2nnn3cnc4[nH]ccc4c23)CC1)c1ccc(C(F)(F)F)cc1 CHEMBL3947711 IC50 5.4 nM
N#Cc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)cc1C(F)(F)F CHEMBL3965217 IC50 5.4 nM
O=S(=O)(C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1)c1ccc(F)cc1 CHEMBL3975088 IC50 5.4 nM
N#CC[C@H]1CC[C@@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3902992 IC50 5.4 nM
CN1CN(C2CCCCC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3954540 IC50 5.4 nM
Cc1nccc(Nc2cc(NC3CCN(c4ccc(C#N)cn4)CC3)c(C(N)=O)cn2)n1 CHEMBL4591633 IC50 5.4 nM
CN(CC1(C#N)CCCCC1)C1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3897943 Ki 5.48 nM
CCc1cc(O)c(F)cc1-c1cc(NS(=O)(=O)CCC(=O)OC)c2cn[nH]c2c1 CHEMBL4483513 pIC50 5.495 nM
Cn1nc(-c2cnc3[nH]cc(C(=O)N[C@@H](C(=O)N4CC(C#N)C4)C(C)(C)C)c3n2)c2ccc(Cl)cc21 CHEMBL2376155 IC50 5.5 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@H](c3ccccc3F)C2)CC1 CHEMBL3652364 IC50 5.5 nM
O=S1(=O)CCN(C[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)CC1 CHEMBL3896777 IC50 5.5 nM
CN(CC#N)C[C@H]1CC[C@H](N2CN(C)C(=O)c3cnc4[nH]ccc4c32)CC1 CHEMBL3943509 IC50 5.5 nM
C[C@H](c1ccc(F)cn1)n1c(=O)[nH]c2cnc(-c3cnc4ccc(F)cn34)nc21 CHEMBL4536396 IC50 5.5 nM
N#CC[C@H]1CC[C@H](n2c(=O)[nH]c3cnc(Nc4ccc[nH]c4=O)nc32)CC1 CHEMBL4463007 IC50 5.5 nM
Cc1nc2cnc3ccc(-c4cc(Cl)c(O)c(Cl)c4)cc3c2n1[C@H]1CCCN(C)C1 CHEMBL5170534 IC50 5.5 nM
FC(F)(F)Oc1ccc(CNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3986660 IC50 5.6 nM
FC(F)(F)c1nc2cc(NC[C@H]3CC[C@H](c4nnn5cnc6[nH]ccc6c45)CC3)ccc2[nH]1 CHEMBL3965670 IC50 5.6 nM
CCCn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(c5ccc(C#N)cn5)C[C@H]4C)c3n2)cn1 CHEMBL3937711 IC50 5.6 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)ccc1OC(F)F)c1cnc2[nH]ccc2n1 CHEMBL4791878 Ki 5.6 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(Cl)cc2)[C@@H](C)C1 CHEMBL4777577 IC50 5.67 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(OC)cc2)C[C@@H]1F CHEMBL5404261 IC50 5.68 nM
CN1CCN(C(=O)c2ccc3[nH]c4c(C(N)=O)cc(-c5ccc(Cl)cc5)cc4c3c2)CC1 CHEMBL3589169 IC50 5.7 nM
c1ccc(CCNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3912419 IC50 5.7 nM
O=C(NCS(=O)(=O)c1ccccc1)[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3928338 IC50 5.7 nM
O=S(=O)(C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1)NCC(F)(F)F CHEMBL3979623 IC50 5.7 nM
CC(C)n1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(c5ncc(C#N)cn5)C[C@H]4C)c3n2)cn1 CHEMBL3903685 IC50 5.7 nM
COc1ccc(Cl)cc1-c1nn(C)cc1NC(=O)c1cncc2[nH]cnc12 CHEMBL4745011 Ki 5.7 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1ccc(C(=O)NO)cc1 CHEMBL5408198 IC50 5.7 nM
N[C@H]1CC[C@H](n2cnc3cnc4[nH]ccc4c32)CC1 CHEMBL2152414 Ki 5.8 nM
Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](O)CC1 CHEMBL2159209 Ki 5.8 nM
CS(=O)(=O)NCc1nc2cnc3[nH]ccc3c2n1C1CCCOC1 CHEMBL2206627 Ki 5.8 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(C#N)nc4)cc23)CC[C@]1(C)C(N)=O CHEMBL3671831 IC50 5.8 nM
N#Cc1ccc(NC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3983303 IC50 5.8 nM
Fc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)c(F)c1 CHEMBL3907770 IC50 5.8 nM
CC[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cn(C)nc3C)nc12 CHEMBL3896771 IC50 5.8 nM
CC[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C[C@@H](C)O)c3)nc12 CHEMBL3890933 IC50 5.8 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CN(S(=O)(=O)c2cccc(C#N)c2)CC12CC2 CHEMBL4293578 IC50 5.8 nM
CN(c1ncnc2[nH]ccc12)C1CCC(CS(=O)(=O)N2CC[C@@H](O)C2)CC1 CHEMBL3953856 IC50 5.84 nM
CN1C[C@@H]2CN(Cc3nc(-c4cc(Cl)ccc4OC(F)F)c(NC(=O)c4cnn5cccnc45)s3)C[C@@H]2C1 CHEMBL3914707 Ki 5.84 nM
N#Cc1cccc(CN[C@H]2CC[C@H](n3cnc4cnc5[nH]ccc5c43)CC2)c1 CHEMBL2152421 Ki 5.9 nM
N#CCCN[C@H]1CC[C@H](n2nnc3cnc4[nH]ccc4c32)CC1 CHEMBL2392480 Ki 5.9 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(Cc3ccnc(C#N)c3)C4)n[nH]c2c1 CHEMBL3644634 IC50 5.9 nM
c1cc2c(ncn3nnc([C@H]4CC[C@H](CN5CCC5)CC4)c23)[nH]1 CHEMBL3930431 IC50 5.9 nM
Cc1ccc(CNC(=O)[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)o1 CHEMBL3908073 IC50 5.9 nM
CC[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C4CC4)c3)nc12 CHEMBL3963248 IC50 5.9 nM
CC[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C(C)C)c3)nc12 CHEMBL3936210 IC50 5.9 nM
N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3c2CCN3)cn1 CHEMBL4637163 IC50 5.9 nM
C#CCC1(n2cc(-c3ncnc4[nH]ccc34)cn2)CN(S(=O)(=O)CC)C1 CHEMBL5427854 IC50 5.9 nM
Cc1cnc(Nc2ccc(N3CCN(C)CC3)c(F)c2)nc1Nc1ccc(C(=O)Nc2ccccc2N)cc1 CHEMBL5435038 IC50 5.9 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCCC(COc3ccc(F)cc3)C2)CC1 CHEMBL3652288 IC50 5.91 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2C[C@@H](O)[C@H](O)C2)CC1 CHEMBL3652343 IC50 5.92 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC(Cc3ncccn3)CC2)CC1 CHEMBL3652318 IC50 5.98 nM
CN(c1ncnc2[nH]ccc12)[C@H]1C[C@@H](NS(=O)(=O)CC2(CC#N)COC2)C1 CHEMBL3655085 IC50 6.0 nM
[C-]#[N+][C@H]1C[C@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(OC(F)(F)F)cc2)n1 CHEMBL3702937 IC50 6.0 nM
CC(C)CN[C@H]1CC[C@@H](n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)cc3)n2)[C@H](C#N)C1 CHEMBL3647819 IC50 6.0 nM
COC(=O)c1ncc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1C CHEMBL3702899 IC50 6.0 nM
CN(c1ncnc2[nH]ccc12)[C@H]1C[C@@H](CS(=O)(=O)N2CCC(O)(C(F)(F)F)CC2)C1 CHEMBL3658857 IC50 6.0 nM
[C-]#[N+][C@H]1C[C@H](OCC2CC2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccnc(F)c2)n1 CHEMBL3702960 IC50 6.0 nM
N#C[C@H]1C[C@@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)nc2)n1 CHEMBL3702991 IC50 6.0 nM
Cn1cc(-c2cncc(Nc3nn(C4CCCC[C@@H]4C#N)cc3C(N)=O)c2)cn1 CHEMBL3702931 IC50 6.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(F)c(Cl)c2)n1 CHEMBL3699559 IC50 6.0 nM
[C-]#[N+][C@@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(CC(=O)O)cc2)n1 CHEMBL3699478 IC50 6.0 nM
CC(C)NC(=O)O[C@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647873 IC50 6.0 nM
N#C[C@H]1C[C@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C3CC3)cc2)n1 CHEMBL3702950 IC50 6.0 nM
N#C[C@H]1C[C@H](O)CCC1n1cc(C(N)=O)c(Nc2ccccc2)n1 CHEMBL3699464 IC50 6.0 nM
CN(c1ncnc2[nH]ccc12)[C@H]1C[C@@H](CS(=O)(=O)c2cc(C#N)ccn2)C1 CHEMBL3658868 IC50 6.0 nM
CN(c1ncnc2[nH]ccc12)[C@H]1C[C@@H](NS(=O)(=O)C2CN(C3CC3)C2)C1 CHEMBL3655096 IC50 6.0 nM
CN(c1ncnc2[nH]ccc12)[C@H]1C[C@@H](NS(=O)(=O)[C@H]2C[C@H](CC#N)C2)C1 CHEMBL3655083 IC50 6.0 nM
[C-]#[N+][C@H]1C[C@@H](C(=O)N2CC(C)(C)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647875 IC50 6.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2cnc3ccc(Cl)cc3c2)n1 CHEMBL3699561 IC50 6.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(OC(F)F)nc2)n1 CHEMBL3702923 IC50 6.0 nM
N#Cc1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cn1 CHEMBL3702896 IC50 6.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)Nc3ccc(C(F)(F)F)cc3)cc2)n1 CHEMBL3702916 IC50 6.0 nM
CN(C1CCC1)[C@H]1CC[C@@H](n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)cc3)n2)[C@H](C#N)C1 CHEMBL3647820 IC50 6.0 nM
CN(c1ncnc2[nH]ccc12)[C@H]1C[C@@H](NS(=O)(=O)CC2CC(F)(F)C2)C1 CHEMBL3655093 IC50 6.0 nM
Cc1[nH]c(-c2c(N[C@H]3CC[C@@H](N)CC3)cc[nH]c2=O)nc1-c1ccccc1 CHEMBL3780977 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2cncc3ccccc23)CC1 CHEMBL3967557 IC50 6.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(CO)c3)n2)CC1 CHEMBL3896424 IC50 6.0 nM
COc1cc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)ccn1 CHEMBL3908597 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(C4CC4)c3)n2)CCN(C(=O)OCC(F)F)CC1 CHEMBL3899737 IC50 6.0 nM
Cc1cc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)nc(C)n1 CHEMBL3927951 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(Cc2ccc(-c3ccccc3)cc2)CC1 CHEMBL3971783 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2cn[nH]c2)CC1 CHEMBL3969454 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(CC2CCCCC2)CC1 CHEMBL3943338 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2cscn2)CC1 CHEMBL3935528 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2cocn2)CC1 CHEMBL3968639 IC50 6.0 nM
Cc1cc(CN2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccnc(F)c4)n3)CC2)no1 CHEMBL3930094 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2cccnn2)CC1 CHEMBL3941105 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(Cc2cccnn2)CC1 CHEMBL3905110 IC50 6.0 nM
CC(OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1)C1CC1 CHEMBL3977586 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)OCC2CCOCC2)CC1 CHEMBL3950104 IC50 6.0 nM
CC(C)(C)COC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1 CHEMBL3933703 IC50 6.0 nM
CS(=O)(=O)c1ccc(Nc2nn(C3(CC#N)CN(C(=O)OC4CCCC4)C3)cc2C(N)=O)cc1 CHEMBL3974659 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)c2ccccc2)CC1 CHEMBL3918038 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)c2cc3ccccc3[nH]2)CC1 CHEMBL3938961 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)c2ccc3ccccc3n2)CC1 CHEMBL3892346 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CN(C(=O)Nc2ccc(F)cc2F)C1 CHEMBL4110698 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(=O)CC1 CHEMBL3949820 IC50 6.0 nM
CC(C)(C)OC(=O)N1CC[C@H](C#N)[C@@H](n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1 CHEMBL4113261 IC50 6.0 nM
N#C[C@@H]1CN(C(=O)OC(CF)CF)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL4114118 IC50 6.0 nM
CC(OC(=O)N1CC[C@@H](C#N)[C@H](n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1)C1CC1 CHEMBL3903415 IC50 6.0 nM
N#C[C@@H]1CCN(C(=O)OCCF)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3916210 IC50 6.0 nM
CC(C)(C)COC(=O)N1CC[C@@H](C#N)[C@H](n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1 CHEMBL3891708 IC50 6.0 nM
CCOC(=O)COC(=O)N1CC[C@@H](C#N)[C@H](n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1 CHEMBL3939728 IC50 6.0 nM
N#C[C@@H]1CCN(C(=O)OC2CCOCC2)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3961679 IC50 6.0 nM
N#C[C@@H]1CCN(Cc2cccnn2)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3917035 IC50 6.0 nM
N#C[C@@H]1CCN(CCC2CCOCC2)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3980441 IC50 6.0 nM
CC1=NOC(CN2CC[C@@H](C#N)[C@H](n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)C2)C1 CHEMBL3963053 IC50 6.0 nM
N#C[C@@H]1CCN(CC2CCOC2)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3954457 IC50 6.0 nM
N#C[C@@H]1CN(Cc2cocn2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL4108063 IC50 6.0 nM
N#C[C@@H]1CN(Cc2cncc(F)c2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL4114959 IC50 6.0 nM
CC1(c2ccc(Nc3nn([C@@H]4COCC[C@H]4C#N)cc3C(N)=O)cc2)COC1 CHEMBL3895925 IC50 6.0 nM
Cc1cnc(Nc2cnn(C)c2)nc1NC1CCC2(CC1)CCN(C(=O)CC#N)CC2 CHEMBL3908086 IC50 6.0 nM
CSCN1CN([C@H]2CC[C@H](CNCC(F)(F)F)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3966746 IC50 6.0 nM
CN(c1ncnc2[nH]ccc12)[C@H]1C[C@@H](NS(=O)(=O)c2ccccc2)C1 CHEMBL4101374 IC50 6.0 nM
Cc1cnc(Nc2cc(N3CCN(CCO)CC3)cc(S(C)(=O)=O)c2)nc1Nc1cccc(CO)c1 CHEMBL4177188 IC50 6.0 nM
COc1ccc(-c2cc3c(N[C@H](CO)[C@@H](C)O)c(C(N)=O)cnn3c2)cn1 CHEMBL4547761 IC50 6.0 nM
C[C@@H]1[C@@H]2CN(c3nc(Nc4cnn(CCO)c4)ncc3F)C[C@]12NC(=O)[C@@H]1C[C@H]1C#N CHEMBL4644578 IC50 6.0 nM
O=C(Nc1nc2cccc(C3CCC4(CC3)CN(C(=O)C3CC3(F)F)C4)n2n1)C1CC1 CHEMBL5200095 IC50 6.0 nM
COCCOC(=O)Cc1ccc(Nc2cc(Nc3ccccc3OC)c(C(N)=O)cn2)nc1 CHEMBL5422886 IC50 6.0 nM
CCCS(=O)(=O)CC1CCCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 CHEMBL3652290 IC50 6.06 nM
CC(C)(C)OC(=O)N[C@H]1CC[C@H](n2cnc3cnc4[nH]ccc4c32)CC1 CHEMBL2152412 Ki 6.1 nM
CC(C)(C)OC(=O)N[C@H]1CC[C@@H](n2cnc3cnc4[nH]ccc4c32)CC1 CHEMBL2152413 Ki 6.1 nM
CC(=O)N[C@H]1CC[C@H](n2c(C)nc3cnc4[nH]ccc4c32)CC1 CHEMBL2159207 Ki 6.1 nM
[C-]#[N+]c1ccc(-c2cc3c(N[C@H]4CC[C@@](C)(O)CC4)c(C(N)=O)cnn3c2)cc1 CHEMBL3671797 IC50 6.1 nM
Fc1cccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)c1 CHEMBL3957937 IC50 6.1 nM
c1ccc(CCNC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3967682 IC50 6.1 nM
Cc1cnc(CNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cn1 CHEMBL3973302 IC50 6.1 nM
CC[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3ccnc(C)c3)nc12 CHEMBL3917516 IC50 6.1 nM
COc1cc(O)ccc1-c1ccc2c(-c3nc4ccccc4[nH]3)n[nH]c2c1 CHEMBL3914503 IC50 6.1 nM
CS(=O)(=O)N1CCC(n2nnc3cnc4[nH]ccc4c32)CC1 CHEMBL2392489 Ki 6.2 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(Cc3ccc(Oc5ccccc5)nc3)C4)n[nH]c2c1 CHEMBL3644637 IC50 6.2 nM
CS(=O)(=O)N1C[C@H](CF)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(C(F)(F)F)nc4)cc23)C1 CHEMBL3672475 IC50 6.2 nM
N#CCN[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3941431 IC50 6.2 nM
c1ccc(CCN[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3906263 IC50 6.3 nM
O=C1c2cnc3[nH]ccc3c2N([C@H]2CC[C@H](CF)CC2)CN1C1CC1 CHEMBL3960523 IC50 6.3 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CN(S(=O)(=O)c2ccc([N+](=O)[O-])cc2)CC12CC2 CHEMBL4276966 IC50 6.3 nM
CCOCCO[C@@H]1CCN(S(=O)(=O)CC2CCC(N(C)c3ncnc4[nH]ccc34)CC2)C1 CHEMBL3929066 IC50 6.31 nM
Cc1[nH]nc2[nH]c(=O)cc([C@H]3CC[C@H](NC(=O)[C@@H]4CC4(F)F)CC3)c12 CHEMBL4639973 IC50 6.4 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@H](C(N)=O)C2)CC1 CHEMBL3652330 IC50 6.45 nM
C[C@H]1CCCN1S(=O)(=O)C[C@H]1CC[C@H](N(C)c2ncnc3[nH]ccc23)CC1 CHEMBL3652357 IC50 6.47 nM
Cc1ccc(N2CCN(S(=O)(=O)C[C@H]3CC[C@H](N(C)c4ncnc5[nH]ccc45)CC3)CC2)nc1C CHEMBL3652389 IC50 6.48 nM
C[C@@H]1C[C@@H](CS(=O)(=O)N2CC[C@@H](CO)C2)CC[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL3652401 IC50 6.5 nM
N#Cc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)cc1C#N CHEMBL3964133 IC50 6.5 nM
c1cc2c(ncn3nnc([C@H]4CC[C@H](CN5CCCC5)CC4)c23)[nH]1 CHEMBL3900631 IC50 6.5 nM
N#CCN1CN([C@H]2CC[C@H](CNC3CC3)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3913143 IC50 6.5 nM
CN(C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1)C(Cc1ccccc1)C(F)(F)F CHEMBL3932229 Ki 6.51 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(C#N)cc2)C[C@@H]1F CHEMBL5423387 IC50 6.51 nM
COc1cc2c(=O)n(C3CCCCCC3)c3c4cc[nH]c4ncc3c2cc1OC CHEMBL4291720 IC50 6.59 nM
CC1(C)CN(C(=O)c2ccc(-c3cccc4nc(NC(=O)C5CC5)nn34)cc2)C1 CHEMBL3301606 IC50 6.6 nM
CC(C)(C)OC(=O)N[C@H]1CCN(C[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)C1 CHEMBL3947422 IC50 6.6 nM
Fc1ccc(N[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3907565 IC50 6.6 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4cncc(F)c4)cc23)CC[C@]1(C)N CHEMBL4088673 IC50 6.6 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(C#N)nc4)cc23)CC[C@]1(C)N CHEMBL4096795 IC50 6.6 nM
Cc1nc2cnc3ccc(-c4cc(Cl)c(O)c(Cl)c4)cc3c2n1C1CCCN(C)C1 CHEMBL5187370 IC50 6.6 nM
Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@@H](O)CC1 CHEMBL2159212 Ki 6.7 nM
COCC(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL3645119 Kd 6.7 nM
FC1(F)Oc2ccc(NC[C@H]3CC[C@H](c4nnn5cnc6[nH]ccc6c45)CC3)cc2O1 CHEMBL3917954 IC50 6.7 nM
C[C@@H]1CN(c2ccc(C#N)cn2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C[C@@H](C)O)c3)nc12 CHEMBL3914278 IC50 6.7 nM
Cc1cnc(Nc2cc(NC3CCN(c4ccc(C#N)cn4)CC3)c(C(N)=O)cn2)cn1 CHEMBL4471707 IC50 6.7 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@H](Oc3ccccc3C#N)C2)CC1 CHEMBL3652359 IC50 6.73 nM
Cc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)s1 CHEMBL3945676 IC50 6.8 nM
CC[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC)c3)nc12 CHEMBL3896264 IC50 6.8 nM
Cc1nc2cnc3ccc(-c4cc(Cl)c(O)c(Cl)c4)cc3c2n1C1CCOCC1 CHEMBL5181449 IC50 6.8 nM
C[C@@H]1C[C@H](Nc2c(C(N)=O)cnc3[nH]ccc23)CCN1Cc1cccc(Cl)c1 CHEMBL4785998 IC50 6.87 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@@H](c3ccccc3)C2)CC1 CHEMBL3652371 IC50 6.89 nM
CC(C)[C@H](C)n1cc(-c2ccc(N3CCOCC3)cn2)c2[nH]nc(N)c2c1=O CHEMBL3763991 IC50 6.9 nM
CC1(NC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)CC1 CHEMBL3904186 IC50 6.9 nM
FC1CN(C[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)C1 CHEMBL3985390 IC50 6.9 nM
O=C(NCC(O)(c1ccc(F)cc1)C(F)(F)F)[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3917056 IC50 6.9 nM
C[C@@H]1CN(c2nnc(C(F)(F)F)s2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC(C)(C)O)c3)nc12 CHEMBL3985826 IC50 6.9 nM
CCCS(=O)(=O)N1C[C@H](N(C)c2ncnc3[nH]ccc23)C2(CC2)C1 CHEMBL4285473 IC50 6.9 nM
CN(C(=O)OC(C)(C)C)[C@H]1CCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 CHEMBL3652363 IC50 6.91 nM
CCc1cc(O)c(F)cc1-c1cc(NS(=O)(=O)C(C)C)c2cn[nH]c2c1 CHEMBL4517645 pIC50 6.918 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@@H](O)[C@@H](O)C2)CC1 CHEMBL3652286 IC50 6.99 nM
N#CC1CCCC1Nc1ncnc2c(=O)[nH]ccc12 CHEMBL2436967 Ki 7.0 nM
CN(C(C1CC1)C1CC1)[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647752 IC50 7.0 nM
N#C[C@H]1C[C@@H](OC(=O)Nc2ccccc2)CCC1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3647866 IC50 7.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2cc(F)cc(Cl)c2)n1 CHEMBL3699552 IC50 7.0 nM
CN(C)[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(OC(F)F)nc3)n2)[C@@H](C#N)C1 CHEMBL3702994 IC50 7.0 nM
N#Cc1ncc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1F CHEMBL3702900 IC50 7.0 nM
CC(C)(C)OC(=O)C1CC[C@H](C#N)C(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1 CHEMBL3699498 IC50 7.0 nM
N#C[C@H]1C[C@@H](C(=O)NCC(F)(F)F)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647895 IC50 7.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2cncc(Cl)c2)n1 CHEMBL3699548 IC50 7.0 nM
N#C[C@H]1C[C@H](OC(=O)NC2CCCCC2)CCC1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3647870 IC50 7.0 nM
CC1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1 CHEMBL3699494 IC50 7.0 nM
CC1(C)CCN1[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647770 IC50 7.0 nM
CN(C)[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)c(F)c3)n2)[C@@H](C#N)C1 CHEMBL3703017 IC50 7.0 nM
CC(C)(CNC(=O)OC(C)(C)C)CNc1cc[nH]c(=O)c1-c1nc2c([nH]1)CCCC2 CHEMBL3781476 IC50 7.0 nM
Fc1ccc(CN[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3980095 IC50 7.0 nM
OCC1(NC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)CC1 CHEMBL3939232 IC50 7.0 nM
Cc1ccncc1N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1 CHEMBL3900321 IC50 7.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC2(CC1)OCCO2 CHEMBL3984652 IC50 7.0 nM
COc1cc(Nc2nn(C3(CC#N)CCN(C(=O)OCC(F)F)CC3)cc2C(N)=O)ccn1 CHEMBL3894307 IC50 7.0 nM
CC(=O)Nc1ccc(CN2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccccc4)n3)CC2)cc1 CHEMBL3981986 IC50 7.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)OCc2ccccn2)CC1 CHEMBL3979073 IC50 7.0 nM
COc1ccc(CC(=O)N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccccc4)n3)CC2)cc1 CHEMBL3926489 IC50 7.0 nM
Cc1ccc(C)c(NC(=O)N2CC(CC#N)(n3cc(C(N)=O)c(Nc4ccccc4)n3)C2)c1 CHEMBL4114510 IC50 7.0 nM
CCCNC(=O)N1CC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1 CHEMBL3960898 IC50 7.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CN(C(=O)Nc2ccc(F)c(F)c2)C1 CHEMBL4115252 IC50 7.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CCC(Nc2ccc(O)cc2)CC1 CHEMBL3966245 IC50 7.0 nM
N#CC[C@]1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC[C@@H](C(=O)NCC(F)(F)F)CC1 CHEMBL3983711 IC50 7.0 nM
N#C[C@@H]1CNCC[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL4112066 IC50 7.0 nM
N#C[C@@H]1CN(Cc2cnccn2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL4107174 IC50 7.0 nM
Cc1cc(CN2CC[C@@H](n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)[C@H](C#N)C2)no1 CHEMBL4115501 IC50 7.0 nM
CCn1ccnc1CN1CC[C@@H](n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)[C@H](C#N)C1 CHEMBL4109371 IC50 7.0 nM
Cc1cnc(Nc2cnn(C)c2)nc1NC1CCC2(CC1)CCN(C(=O)CC#N)C2 CHEMBL3894803 IC50 7.0 nM
Cn1cc(Nc2ncc(Cl)c(NC3CN(C(=O)CC#N)CC34CCCC4)n2)cn1 CHEMBL3959356 IC50 7.0 nM
Cc1c(Nc2ncc(Cl)c(NC3CC4CN(C(=O)CC#N)CC4C3)n2)cnn1C CHEMBL3971189 IC50 7.0 nM
CCN1CN([C@H]2CC[C@H](CN(C)S(C)(=O)=O)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3910814 IC50 7.0 nM
COc1nn(C)cc1Nc1ncc(Cl)c(-c2c[nH]c3c(NC(=O)[C@@H](C)N4CCN(C)CC4)cccc23)n1 CHEMBL4064366 IC50 7.0 nM
N#CCNC(=O)c1ccc(-c2nc(Nc3ccc(N4CCC(N5CCOCC5)CC4)cc3)ncc2F)cc1 CHEMBL5180789 IC50 7.0 nM
Cc1cc(Nc2ncc(C)c(N3CC(CC#N)(N4CCN(C)CC4)C3)n2)sn1 CHEMBL5396135 IC50 7.0 nM
CN(CC1(C#N)CCCCC1)C1CCN(C(=O)c2ccc(-n3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)cc2)CC1 CHEMBL3958362 Ki 7.05 nM
CC(=O)C1CCCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 CHEMBL3652279 IC50 7.07 nM
N#Cc1ccc(NC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)c(F)c1 CHEMBL3975250 IC50 7.1 nM
c1cc2c(ncn3nnc([C@H]4CC[C@H](CN5CCSC5)CC4)c23)[nH]1 CHEMBL3947889 IC50 7.1 nM
Cc1nn(C)c(C)c1-c1cn2ncc(C(N)=O)c(N[C@H]3CN(C(=O)C(C)(C)C#N)C[C@H]3C)c2n1 CHEMBL3951139 IC50 7.1 nM
O=C1c2cnc3[nH]ccc3c2N([C@H]2CC[C@H](CNCC(F)F)CC2)CN1C1CC1 CHEMBL3933776 IC50 7.1 nM
OC[C@H](O)c1nc2cnc3[nH]ccc3c2n1C1CCCCC1 CHEMBL2386644 Ki 7.2 nM
O[C@@H](CN[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1)c1ccccc1 CHEMBL3898196 IC50 7.2 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4cccc(C#N)c4)cc23)CC[C@]1(C)N CHEMBL4070687 IC50 7.2 nM
CCS(=O)(=O)N1C[C@H](N(C)c2ncnc3[nH]ccc23)C2(CC2)C1 CHEMBL4283965 IC50 7.2 nM
Cc1nc2cnc3ccc(-c4cc(Cl)c(O)c(Cl)c4)cc3c2n1[C@H]1CC[C@H](CO)CC1 CHEMBL5202812 IC50 7.2 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCCC(C(F)(F)F)C2)CC1 CHEMBL3652280 IC50 7.25 nM
Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CCC[C@@H](O)C1 CHEMBL2159211 Ki 7.3 nM
CS(=O)(=O)NCc1nc2cnc3[nH]ccc3c2n1C1CCN(CCC#N)CC1 CHEMBL2206621 Ki 7.3 nM
FC1(F)CCN(C[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)C1 CHEMBL3931713 IC50 7.3 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@H](S(=O)(=O)Cc3ccccc3)C2)CC1 CHEMBL3652353 IC50 7.34 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@@H](F)C2)CC1 CHEMBL3652307 IC50 7.35 nM
COc1cc(-c2cnc3[nH]cc(C(=O)N[C@H](C)C(=O)N4CC(C#N)C4)c3n2)cc(OC)c1OC CHEMBL2376040 IC50 7.4 nM
Cc1cc(NC(=O)c2cnn3ccc(N)nc23)n(-c2cc(Cl)ccc2C)n1 CHEMBL3670390 Ki 7.4 nM
O=C1OCCC1NC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3960109 IC50 7.4 nM
CCNC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3923711 IC50 7.4 nM
N#Cc1ccc(CCNC(=O)[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3986443 IC50 7.4 nM
CC(C)(O)c1cn(C[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)nn1 CHEMBL3963480 IC50 7.4 nM
Cc1nc2cnc3ccc(-c4cc(Cl)c(O)c(Cl)c4)cc3c2n1C1CCN(CN(C)C)CC1 CHEMBL5193593 IC50 7.4 nM
CC(=O)Nc1cc(Nc2cccc(S(C)(=O)=O)c2)c(-c2ccccn2)cn1 CHEMBL5417355 IC50 7.4 nM
C[C@@H]1C[C@@H](CS(=O)(=O)N2CCC(CO)CC2)CC[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL3652399 IC50 7.41 nM
CC[C@@H]1CN(C(=O)CC(F)(F)F)CC[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)cc12 CHEMBL3667486 IC50 7.5 nM
N#Cc1ccc(CNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3908040 IC50 7.5 nM
FC(F)CN[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3946758 IC50 7.5 nM
CN(C)C(=O)CN1CN([C@H]2CC[C@H](CNCC(F)(F)F)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3901870 IC50 7.5 nM
CCc1cc(O)ccc1-c1ccc2c(C(=O)NC)n[nH]c2c1 CHEMBL4078165 IC50 7.5 nM
C[C@@H]1CCN(C(=O)N2CCCC2)C[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL4068357 IC50 7.5 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1n1ncc2cnc3[nH]ccc3c21 CHEMBL5276916 IC50 7.5 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@@](C)(O)C2)CC1 CHEMBL3652336 IC50 7.6 nM
CC[C@@H]1CN(C(=O)[C@@H](O)CC)CC[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)cc12 CHEMBL3667482 IC50 7.6 nM
N#C[C@H]1CCN(C[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)C1 CHEMBL4107757 IC50 7.6 nM
CC1(C)CC1NC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3962117 IC50 7.6 nM
OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(C[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)CC1 CHEMBL3956966 IC50 7.6 nM
O=C(N[C@@H]1CCN(C[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)C1)C(F)(F)F CHEMBL4112721 IC50 7.6 nM
O=C(Nc1nc2cccc(-c3ccc(CN4CCC(F)(F)CC4)cc3)n2n1)C1CC1 CHEMBL3360356 IC50 7.69 nM
CN(C)S(=O)(=O)C[C@H]1CCCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 CHEMBL3652329 IC50 7.7 nM
O=C(c1ccc(F)cc1)N1CCc2[nH]c(-c3n[nH]c4cc(-c5cc(F)c(O)cc5CC(F)(F)F)ccc34)nc2C1 CHEMBL3644639 IC50 7.7 nM
N#CC1CN(C[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)C1 CHEMBL3939325 IC50 7.7 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC(C)(O)CC2)CC1 CHEMBL3652296 IC50 7.74 nM
CN(C)C1CCN(Cc2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3910933 Ki 7.74 nM
CS(=O)(=O)c1ccc(CNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3943994 IC50 7.8 nM
O=S(=O)(C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1)NC1CC1 CHEMBL3985119 IC50 7.8 nM
COC12CC3CC(C1)C(Nc1c(C(N)=O)cnc4[nH]ccc14)C(C3)C2 CHEMBL4246788 IC50 7.8 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cc(F)cnc12 CHEMBL4755436 Ki 7.8 nM
[2H]C([2H])([2H])NC(=O)c1cnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncc(F)cn2)c1OC CHEMBL4789639 IC50 7.8 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2cccc(OC)c2)C[C@H]1F CHEMBL4742766 IC50 7.86 nM
CC1(n2nnc3cnc4[nH]ccc4c32)CCN(S(C)(=O)=O)CC1 CHEMBL2392493 Ki 7.9 nM
Fc1ccc([C@@H]2C[C@H]2CN[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3922303 IC50 7.9 nM
CC[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cn(CC(C)(C)O)nc3C)nc12 CHEMBL3966881 IC50 7.9 nM
CC(C)Oc1ccc(Cl)cc1-c1nn(C)cc1NC(=O)c1cnn2cccnc12 CHEMBL4794314 Ki 7.9 nM
COc1cc(-c2cnc3cccc(-c4cc(F)c(CN5CCS(=O)(=O)CC5)c(F)c4)c3n2)ccc1OCCCN1CCOCC1 CHEMBL4634979 pIC50 7.943 nM
Cn1cc(Nc2ncc3cccc(NC4CCNCC4)c3n2)cn1 CHEMBL5076598 pIC50 7.943 nM
CCc1c(-c2cc(OC)c3nc(N)ncc3c2)ccc(O)c1F CHEMBL5089877 pIC50 7.943 nM
N#C[C@H]1C[C@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)nc2)n1 CHEMBL3703012 IC50 8.0 nM
CN(C)[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)nc3)n2)[C@@H](C#N)C1 CHEMBL3703005 IC50 8.0 nM
N#C[C@H]1C[C@@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)F)nc2)n1 CHEMBL3647854 IC50 8.0 nM
CN(c1ncnc2[nH]ccc12)[C@H]1C[C@@H](NS(=O)(=O)N2C[C@H]3C[C@@]3(C#N)C2)C1 CHEMBL3658853 IC50 8.0 nM
N#C[C@H]1C[C@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(OC(F)F)nc2)n1 CHEMBL3702938 IC50 8.0 nM
CN(C)[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)nc3)n2)[C@@H](C#N)C1 CHEMBL3703002 IC50 8.0 nM
C[C@H](N[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)c(F)c3)n2)[C@@H](C#N)C1)C1CC1 CHEMBL3703026 IC50 8.0 nM
N#C[C@H]1CCC[C@@H]1n1cc(C(N)=O)c(Nc2ccccc2)n1 CHEMBL3699459 IC50 8.0 nM
CC(CN)(CNC(=O)OC(C)(C)C)CNc1cc[nH]c(=O)c1-c1nc2c([nH]1)CCCC2 CHEMBL3780249 IC50 8.0 nM
COc1ccc(-c2cc3c(N[C@H]4CCN(C(=O)[C@H](C)O)CC4(C)C)c(C(N)=O)cnn3c2)cn1 CHEMBL3672471 IC50 8.0 nM
COc1ccc(-c2cc3c(N[C@@H]4CN(S(C)(=O)=O)C[C@@H]4OC)c(C(N)=O)cnn3c2)cn1 CHEMBL3672469 IC50 8.0 nM
Fc1ccccc1CN1CCC(c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3945964 IC50 8.0 nM
N#CCCN1CCN(C[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)CC1 CHEMBL3973072 IC50 8.0 nM
N#Cc1ccc(CNC(=O)[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3945378 IC50 8.0 nM
CC(C)(C)OC(=O)N1CC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1 CHEMBL4107287 IC50 8.0 nM
Cc1cc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)ccn1 CHEMBL3963309 IC50 8.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCSCC1 CHEMBL3892372 IC50 8.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccn3)n2)CC1 CHEMBL3951373 IC50 8.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cnccn3)n2)CC1 CHEMBL3934663 IC50 8.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(Cc2ccc3c(c2)OCO3)CC1 CHEMBL3973983 IC50 8.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2cc3ccccn3n2)CC1 CHEMBL3924304 IC50 8.0 nM
CC1(COC(=O)N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)COC1 CHEMBL3958656 IC50 8.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)OC2CCCCC2)CC1 CHEMBL3952618 IC50 8.0 nM
COc1ccc(C(=O)N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccccc4)n3)CC2)cc1 CHEMBL3945544 IC50 8.0 nM
CC1(C(=O)N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccnc(F)c4)n3)CC2)CCC1 CHEMBL3980147 IC50 8.0 nM
CCc1cccc(NC(=O)N2CC(CC#N)(n3cc(C(N)=O)c(Nc4ccccc4)n3)C2)c1 CHEMBL3938914 IC50 8.0 nM
Cc1ccc(NC(=O)N2CC(CC#N)(n3cc(C(N)=O)c(Nc4ccccc4)n3)C2)cc1F CHEMBL4110026 IC50 8.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(N2CCC(O)CC2)CC1 CHEMBL3900088 IC50 8.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(NCCF)CC1 CHEMBL3909552 IC50 8.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(NS(=O)(=O)c2cccc(F)c2)CC1 CHEMBL3941871 IC50 8.0 nM
CC(C)(C)CCOC(=O)N1CC[C@@H](C#N)[C@H](n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1 CHEMBL3942861 IC50 8.0 nM
N#C[C@@H]1CN(C(=O)OCC(F)F)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL4113767 IC50 8.0 nM
CC(OC(=O)N1CC[C@@H](C#N)[C@H](n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1)C(F)(F)F CHEMBL3893379 IC50 8.0 nM
COCCOC(=O)N1CC[C@@H](C#N)[C@H](n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1 CHEMBL3972715 IC50 8.0 nM
CC[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC(C)(C)O)c3)nc12 CHEMBL3913520 IC50 8.0 nM
CN(c1ncnc2[nH]ccc12)[C@H]1C[C@@H](NS(=O)(=O)CCCC(F)(F)F)C1 CHEMBL4079179 IC50 8.0 nM
CC1(NC#N)CCc2ccc(-c3ncnc4[nH]ccc34)cc21 CHEMBL4293778 IC50 8.0 nM
COc1nn(C)cc1Nc1ncc(Br)c(-c2c[nH]c3c(NC(=O)[C@@H](C)N4CCN(C)CC4)cccc23)n1 CHEMBL4577393 IC50 8.0 nM
CCC1(C(N)=O)CCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)CC1 CHEMBL3652316 IC50 8.01 nM
C[C@@H](O)CNC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL4109199 IC50 8.1 nM
c1cc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)ccn1 CHEMBL3905498 IC50 8.1 nM
C=C1CCC(c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3907503 IC50 8.1 nM
CC(=O)Nc1cc2c(N[C@@H]3CC[C@@](C)(O)C3(C)C)c(C(N)=O)cnn2c1 CHEMBL3666882 IC50 8.2 nM
CC1(n2cnc3cnc4[nH]ccc4c32)CCN(Cc2cncnc2)CC1 CHEMBL2152408 Ki 8.3 nM
O=C(Nc1nc2cccc(-c3ccc(Cc4ccc(O)c(CO)c4)cc3)n2n1)C1CC1 CHEMBL3360350 IC50 8.3 nM
CCn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(c5ncc(C#N)cn5)C[C@H]4C)c3n2)cn1 CHEMBL3923936 IC50 8.3 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC(c3nc(CS(C)(=O)=O)no3)CC2)CC1 CHEMBL3652322 IC50 8.33 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@](C)(O)C2)CC1 CHEMBL3652370 IC50 8.34 nM
CCOC(=O)NCc1nc2cnc3[nH]ccc3c2n1C1CCN(CCC#N)CC1 CHEMBL2206620 Ki 8.4 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(S(=O)(=O)c3ccc(N5CCOCC5)nc3)C4)n[nH]c2c1 CHEMBL3644621 IC50 8.4 nM
c1ccc(CN[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3985363 IC50 8.4 nM
OC1(CNC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)CCCCC1 CHEMBL3914847 IC50 8.4 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCN(c3ccccn3)CC2)CC1 CHEMBL3652390 IC50 8.43 nM
c1ccc(CN2CCC(n3nnc4cnc5[nH]ccc5c43)CC2)cc1 CHEMBL2392487 Ki 8.5 nM
C#CCNC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3959556 IC50 8.5 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CN(C(=O)CC#N)CC12CC2 CHEMBL4279819 IC50 8.5 nM
Fc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)cc1C(F)(F)F CHEMBL3899570 IC50 8.6 nM
N#C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3902333 IC50 8.6 nM
CNC(=O)c1cnc2[nH]ccc2c1NC1CCCN(Cc2cccc(OC)c2)CC1 CHEMBL4787133 IC50 8.61 nM
N#CCCN1CCC(n2c(CCC3CCCO3)nc3cnc4[nH]ccc4c32)CC1 CHEMBL2206614 Ki 8.7 nM
O=c1[nH]cc(F)cc1Nc1ncc2[nH]c(=O)n([C@@H]3CCOc4c(F)cccc43)c2n1 CHEMBL4526498 IC50 8.7 nM
O=C(CCCCCn1cc(Nc2ncc3ccn(Cc4cccc(F)c4)c3n2)cn1)NO CHEMBL5092781 IC50 8.7 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1ccc(C(=O)Nc2ccccc2N)cc1 CHEMBL5398464 IC50 8.7 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 8.8 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCSC2)CC1 CHEMBL3652394 IC50 8.8 nM
CC(C)NC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3906210 IC50 8.8 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@@](C)(CO)C2)CC1 CHEMBL3652334 IC50 8.88 nM
C[C@@H]1CN(C(=O)C2(C#N)CCC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)nc12 CHEMBL4108712 IC50 8.9 nM
CC[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C[C@H](C)O)c3)nc12 CHEMBL3938736 IC50 8.9 nM
Cc1nc2cnc3ccc(-c4cc(Cl)c(O)c(Cl)c4)cc3c2n1C1CCN(C)CC1 CHEMBL5184867 IC50 8.9 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 9.0 nM
C[C@]1(F)CCC[C@H]1Nc1c(C(N)=O)cnn2cccc12 CHEMBL3359927 IC50 9.0 nM
N#CC1CCC2(CC1n1cc(C(N)=O)c(Nc3ccccc3)n1)OCCO2 CHEMBL3699465 IC50 9.0 nM
CCCCS(=O)(=O)C[C@H]1C[C@@H](N(C)c2ncnc3[nH]ccc23)C1 CHEMBL3658860 IC50 9.0 nM
CN(c1ncnc2[nH]ccc12)[C@H]1C[C@@H](CS(=O)(=O)N2CCC(F)(F)CC2)C1 CHEMBL3658856 IC50 9.0 nM
COc1cccc(N2CCN(S(=O)(=O)c3ccc(Nc4nn([C@H]5CCCC[C@@H]5C#N)cc4C(N)=O)cc3)CC2)c1 CHEMBL3702918 IC50 9.0 nM
CC(C)(O)C1CN(C(=O)[C@@H]2CC[C@@H](n3cc(C(N)=O)c(Nc4ccc(Cl)cc4)n3)[C@H](C#N)C2)C1 CHEMBL3647876 IC50 9.0 nM
CN(c1ncnc2[nH]ccc12)[C@H]1C[C@@H](CS(=O)(=O)[C@H]2CC[C@H](C#N)C2)C1 CHEMBL3658864 IC50 9.0 nM
[C-]#[N+][C@@H]1C[C@@H](N(C)C2COC2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3647814 IC50 9.0 nM
N#C[C@@H]1C[C@H](C(=O)N[C@@H](C2CC2)C(F)(F)F)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647889 IC50 9.0 nM
N#C[C@H]1C[C@@H](C(=O)N[C@H](C2CC2)C(F)(F)F)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647887 IC50 9.0 nM
CC1(CNC(=O)[C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(Cl)cc4)n3)[C@@H](C#N)C2)COC1 CHEMBL3647904 IC50 9.0 nM
N#C[C@H]1C[C@H](NCC(F)F)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccnc(F)c2)n1 CHEMBL3703075 IC50 9.0 nM
[C-]#[N+][C@@H]1C[C@H](C(=O)N2CC(C)(C)C2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3650676 IC50 9.0 nM
N#C[C@@H]1C[C@H](C(=O)N2CC(F)C2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647906 IC50 9.0 nM
COc1ccc(-c2nc3c(NCC4CCNCC4)c(Cl)cnc3[nH]2)c(C)c1 CHEMBL3746766 IC50 9.0 nM
CC[C@@H]1CN(C(=O)[C@@H](C)O)CC[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)cc12 CHEMBL3672450 IC50 9.0 nM
O=C(NCc1ccc(F)cc1)[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3938956 IC50 9.0 nM
Cc1ncccc1N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1 CHEMBL3914684 IC50 9.0 nM
Cc1cncc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)n1 CHEMBL3903164 IC50 9.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(NCC2CC2)CC1 CHEMBL3981419 IC50 9.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(N2Cc3ccccc3C2)CC1 CHEMBL3950882 IC50 9.0 nM
COCCOC(=O)N1CC[C@@H](n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)[C@H](C#N)C1 CHEMBL4112478 IC50 9.0 nM
C#CCCOC(=O)N1CC[C@@H](n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)[C@H](C#N)C1 CHEMBL4106784 IC50 9.0 nM
CN(C)CCOC(=O)N1CC[C@@H](C#N)[C@H](n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1 CHEMBL3934188 IC50 9.0 nM
CC[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3ccn(C)n3)nc12 CHEMBL3922444 IC50 9.0 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CN(S(=O)(=O)c2ccccc2)CC12CC2 CHEMBL4283883 IC50 9.0 nM
CC(=O)N1C2CC1CN(C1CCN(c3ccc(Nc4nccc(-c5ccc(C(=O)NCC#N)cc5)n4)cc3)CC1)C2 CHEMBL5171759 IC50 9.0 nM
C[C@@H]1CCN(c2ccc(C#N)cn2)C[C@@H]1n1c(=O)[nH]c2cnc3[nH]ccc3c21 CHEMBL5278895 IC50 9.0 nM
COc1ccccc1Nc1cc(Nc2ccccn2)ncc1C(N)=O CHEMBL5409666 IC50 9.0 nM
COC(=O)Cc1ccc(Nc2cc(Nc3ccccc3Cl)c(C(N)=O)cn2)nc1 CHEMBL5409953 IC50 9.0 nM
NC(=O)c1cnc(Nc2ccc(CC(=O)O)cn2)cc1Nc1ccccc1Cl CHEMBL5431257 IC50 9.0 nM
CC(C)c1nc2cnc3[nH]ccc3c2n1C1CCN(CCC#N)CC1 CHEMBL2206062 Ki 9.1 nM
O[C@H]1CC[C@@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3943557 IC50 9.1 nM
c1coc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)c1 CHEMBL3891030 IC50 9.1 nM
c1cc2c(ncn3nnc([C@H]4CC[C@H](CNCC5CC5)CC4)c23)[nH]1 CHEMBL3957921 IC50 9.1 nM
CCc1cc(O)c(F)cc1-c1cc(NS(=O)(=O)C2CC2)c2cn[nH]c2c1 CHEMBL4554460 pIC50 9.12 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC(O)CC2)CC1 CHEMBL3639511 IC50 9.18 nM
COc1c(F)cc(Cl)cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12 CHEMBL4796325 Ki 9.2 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(C#N)cc2)C[C@H]1F CHEMBL5410927 IC50 9.23 nM
c1cc2c(ncc3ncn([C@H]4CC[C@H](NCC5CC5)CC4)c32)[nH]1 CHEMBL2152419 Ki 9.3 nM
Cc1nc2cnc3[nH]ccc3c2n1[C@@H]1CCNC[C@@H]1F CHEMBL2159203 Ki 9.3 nM
Cn1ccnc1CCc1nc2cnc3[nH]ccc3c2n1C1CCN(CCC#N)CC1 CHEMBL2206616 Ki 9.3 nM
Fc1ccc(NC[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3909814 IC50 9.3 nM
COc1ccc(S(=O)(=O)N2C[C@H](N(C)c3ncnc4[nH]ccc34)C3(CC3)C2)cc1 CHEMBL4283964 IC50 9.3 nM
CCc1cc(O)c(F)cc1-c1cc(NS(=O)(=O)CCOC)c2cn[nH]c2c1 CHEMBL4569613 pIC50 9.333 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccccc2)C[C@@H]1F CHEMBL5413771 IC50 9.38 nM
CN(c1ncc(C#N)cn1)[C@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3959421 IC50 9.4 nM
CCN1CN([C@H]2CC[C@H](CNCC(F)F)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3907106 IC50 9.4 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CN(S(=O)(=O)c2ccc(F)cc2)CC12CC2 CHEMBL4278452 IC50 9.4 nM
N#CCC(=O)N1CCC[C@H](n2c(=O)[nH]c3cnc(Nc4ccc[nH]c4=O)nc32)C1 CHEMBL4550310 IC50 9.4 nM
CNC(=O)c1cnc2[nH]ccc2c1NC1CCCN(Cc2cccc(Cl)c2)CC1 CHEMBL4759666 IC50 9.43 nM
COC(=O)N[C@H]1CC[C@H](n2cnc3cnc4[nH]ccc4c32)CC1 CHEMBL2151053 Ki 9.5 nM
O=C(Nc1nncs1)N1CCC(c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3969865 IC50 9.5 nM
CN(CCO)C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3942120 IC50 9.5 nM
N#CCN(CC1CC1)C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3942459 IC50 9.5 nM
CN(c1ncnc2[nH]ccc12)[C@@H]1CCN(S(=O)(=O)c2ccc(C(F)(F)F)cc2)C1 CHEMBL4227919 IC50 9.5 nM
CNS(=O)(=O)C[C@H]1CC[C@H](N(C)c2[nH]cnc3nccc2-3)CC1 CHEMBL2103874 IC50 9.53 nM
COC[C@H]1CCCN1S(=O)(=O)C[C@H]1CC[C@H](N(C)c2ncnc3[nH]ccc23)CC1 CHEMBL3652340 IC50 9.55 nM
O=S(=O)(c1ccccc1)N1CCC(n2cnc3cnc4[nH]ccc4c32)CC1 CHEMBL2152397 Ki 9.6 nM
C[C@@H]1CN(c2ccc(C#N)cn2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C[C@H](O)C(F)(F)F)c3)nc12 CHEMBL3923801 IC50 9.6 nM
Cc1nn(C)cc1-c1cn2ncc(C(N)=O)c(N[C@H]3CN(C(=O)C(C)(C)C#N)C[C@H]3C)c2n1 CHEMBL3890788 IC50 9.7 nM
CCCc1cc(O)ccc1-c1ccc2c(-c3nc4ccccc4[nH]3)n[nH]c2c1 CHEMBL4104931 IC50 9.7 nM
Cc1nnc(C2CCCN(S(=O)(=O)C[C@H]3CC[C@H](N(C)c4ncnc5[nH]ccc45)CC3)C2)o1 CHEMBL3652291 IC50 9.75 nM
N[C@H]1CC[C@@H](n2cnc3cnc4[nH]ccc4c32)CC1 CHEMBL2152415 Ki 9.8 nM
c1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3944831 IC50 9.8 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CN(S(=O)(=O)c2ccc(C#N)cc2)CC12CC2 CHEMBL4282998 IC50 9.8 nM
COC(=O)Cn1c(=O)c2cc(OC)c(OC)cc2c2cnc3[nH]ccc3c21 CHEMBL4278842 IC50 9.89 nM
COC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3975158 IC50 9.9 nM
F[C@@H]1CCN(C[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)C1 CHEMBL4112119 IC50 9.9 nM
NC(=O)[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3983344 IC50 9.9 nM
Cc1nc2cnc3ccc(-c4cc(Cl)c(O)c(Cl)c4)cc3c2n1[C@H]1CC[C@H](O)CC1 CHEMBL5177465 IC50 9.9 nM