COCCOC1CCCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 CHEMBL3652408 IC50 0.00405 nM
CC(C)COC1CCCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 CHEMBL3652407 IC50 0.00767 nM
CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)CC1 CHEMBL3665151 IC50 0.0089 nM
COC(=O)N1CCCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665130 IC50 0.0106 nM
CS(=O)(=O)N1CC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665128 IC50 0.0108 nM
C[C@H]1CN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C[C@@H]1CO CHEMBL3652404 IC50 0.0165 nM
CN1CCN(c2ncc(-c3cnc4[nH]ccc4n3)c(N[C@H]3CCCN(S(=O)(=O)CCC(C)(C)C)C3)n2)CC1 CHEMBL3665202 IC50 0.0172 nM
CC(=O)N1CCCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665129 IC50 0.0191 nM
CC(C)CS(=O)(=O)N1CCC[C@H](Nc2nc(N)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665180 IC50 0.0196 nM
C[C@@H]1C[C@@H](CS(=O)(=O)N2CC[C@H](CO)C2)CC[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL3652402 IC50 0.0199 nM
CS(=O)(=O)N1CC[C@@H](O)[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665176 IC50 0.0201 nM
CS(=O)(=O)N1CCCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665131 IC50 0.0209 nM
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3nc(Nc4ccc(C(=O)NCCCN5CCN(c6ccc(C7CCC(=O)NC7=O)cc6)CC5)cc4)nc4[nH]ccc34)cn2)C1 CHEMBL5090416 Kd 0.022 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(N3CCC(CC(N)=O)CC3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665199 IC50 0.0221 nM
CC(=O)N1CCC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665123 IC50 0.0228 nM
CC(C)(C)CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3335690 IC50 0.0245 nM
COC(=O)N1CC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665127 IC50 0.0276 nM
CS(=O)(=O)N1CCC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665119 IC50 0.0292 nM
CSc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(=O)(=O)CCC(C)(C)C)C2)n1 CHEMBL3665188 IC50 0.0293 nM
CS(=O)(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665122 IC50 0.0296 nM
C[C@H]1C[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)CN(S(=O)(=O)CC#N)C1 CHEMBL3665222 IC50 0.0332 nM
FC(F)(F)CN1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665147 IC50 0.035 nM
CS(=O)(=O)N1CCC[C@H](Nc2nccnc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3357978 IC50 0.0359 nM
N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL1789941 Kd 0.036 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC(C)(O)C2)CC1 CHEMBL3652406 IC50 0.0366 nM
Cc1c[nH]c2ncc(-c3cccnc3N[C@H]3CCCN(S(C)(=O)=O)C3)nc12 CHEMBL3665172 IC50 0.0367 nM
CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]cc(C4CC4)c3n2)C1 CHEMBL3665173 IC50 0.0384 nM
CC(=O)N1CC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665126 IC50 0.0397 nM
CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]cc(Cl)c3n2)C1 CHEMBL3665174 IC50 0.0398 nM
N#CCCn1cc(-c2nc(Nc3ccc(NC(=O)CCCCCCC(=O)NO)cc3)nc3[nH]ccc23)cn1 CHEMBL4242626 IC50 0.04 nM
C=CCCn1cc(-c2nc(Nc3ccc(NC(=O)CCCCCCC(=O)NO)cc3)nc3[nH]ccc23)cn1 CHEMBL4247128 IC50 0.041 nM
O=S(=O)(CC1CC1)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665152 IC50 0.0413 nM
Nc1nn2cccnc2c1C(=O)Nc1c[nH]nc1-c1cc(Cl)ccc1OC(F)F CHEMBL4740778 Ki 0.042 nM
CC[C@@H](CO)Nc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(C)(=O)=O)C2)n1 CHEMBL3665200 IC50 0.0432 nM
O=C(Nc1c[nH]nc1-c1cc(I)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL4764019 Ki 0.045 nM
Cc1ccc(-c2cnc3[nH]ccc3n2)c(NC2CCCN(S(C)(=O)=O)C2)n1 CHEMBL3665146 IC50 0.0464 nM
COC(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)CC1 CHEMBL3665124 IC50 0.047 nM
O=C(Nc1c[nH]nc1-c1cc(Br)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL4742159 Ki 0.047 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(N3CC(C#N)C3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665206 IC50 0.0485 nM
CC(C)CS(=O)(=O)N1CCC[C@H](Nc2nc(N3CCOCC3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665184 IC50 0.049 nM
CSc1ccc(OC(F)F)c(-c2n[nH]cc2NC(=O)c2cnc3cccnn23)c1 CHEMBL5268404 Ki 0.05 nM
O=C(Nc1c[nH]nc1-c1cc2cn[nH]c2cc1OC(F)F)c1cnn2cccnc12 CHEMBL4746726 Ki 0.052 nM
CC[C@H](CO)Nc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(C)(=O)=O)C2)n1 CHEMBL3335696 IC50 0.054 nM
CC(C)CS(=O)(=O)N1CCC[C@H](Nc2nc(N(C)C)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665181 IC50 0.0549 nM
CN(C(=O)CC#N)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3955948 IC50 0.055 nM
C=CCN(C1CCCC1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3955757 IC50 0.055 nM
N#Cc1ccc(N(C2CC2)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)nc1 CHEMBL3984764 IC50 0.055 nM
COc1nc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)ccc1C#N CHEMBL3951700 IC50 0.055 nM
N#Cc1ccc2c(c1)CCN2[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3932349 IC50 0.055 nM
CNS(=O)(=O)N(C)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL4115639 IC50 0.055 nM
CCS(=O)(=O)N(C)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3954558 IC50 0.055 nM
CN(c1ccc(C#N)nn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3926930 IC50 0.055 nM
CN(c1ccc(S(C)(=O)=O)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3949972 IC50 0.055 nM
CN(c1ccc(C(F)(F)F)nn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3925768 IC50 0.055 nM
CN(c1ccnc(Cl)n1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3941211 IC50 0.055 nM
CN(CCC#N)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3913220 IC50 0.055 nM
CN(c1ccc(F)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3925605 IC50 0.055 nM
CN(c1ccc(Cl)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3920484 IC50 0.055 nM
CN(c1ccc(C#N)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3896481 IC50 0.055 nM
Cc1cc(Cl)nc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)c1C#N CHEMBL3973848 IC50 0.055 nM
CN(c1ncnc2ccccc12)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3952555 IC50 0.055 nM
N#Cc1ccc(NC2CCN(c3ncnc4[nH]ccc34)C2)nc1 CHEMBL3968548 IC50 0.055 nM
CN(c1cnc(C#N)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3937204 IC50 0.055 nM
COc1cc2ncnc(N(C)[C@@H]3CCN(c4ncnc5[nH]ccc45)C3)c2cc1OC CHEMBL3897417 IC50 0.055 nM
CN(c1nc(Cl)c(C#N)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3930750 IC50 0.055 nM
CN(c1cccc(C#N)n1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3961850 IC50 0.055 nM
CN(C1NC(C#N)=CS1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3903286 IC50 0.055 nM
CN(c1ncc(Br)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3919799 IC50 0.055 nM
CCCN(c1ccc(C#N)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3940099 IC50 0.055 nM
CN(c1ncc(C#N)cc1Br)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3906885 IC50 0.055 nM
CN(c1ccc(C#N)cn1)[C@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3977509 IC50 0.055 nM
CN(c1ccc(C#N)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3915857 IC50 0.055 nM
CN(c1ccc(C#N)cc1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3899672 IC50 0.055 nM
CN(c1ccc(C#N)c2ccccc12)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3982307 IC50 0.055 nM
CN(c1ccc(C#N)c(Br)c1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3921320 IC50 0.055 nM
CN(c1ccnc(C#N)c1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3937835 IC50 0.055 nM
CN(c1ccc(S(=O)(=O)C(F)(F)F)cc1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3956529 IC50 0.055 nM
CN(c1ccc(C(F)(F)F)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3959358 IC50 0.055 nM
N#Cc1ccc(N(CC2CC2)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)nc1 CHEMBL3943572 IC50 0.055 nM
CN(c1cc2cn[nH]c2cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3951178 IC50 0.055 nM
CCN(c1ccc(C#N)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3893327 IC50 0.055 nM
C#CCN(c1ccc(C#N)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3959909 IC50 0.055 nM
C#CCN(c1c(F)cc(C#N)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3930290 IC50 0.055 nM
C#CCN(c1ccc(C#N)cc1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3905748 IC50 0.055 nM
CN(c1cnc(N2CCOCC2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3942728 IC50 0.055 nM
CN(c1cncc(-n2ccnc2)n1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3914739 IC50 0.055 nM
Cc1nc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)ccc1C#N CHEMBL3909092 IC50 0.055 nM
CN(c1ccccn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3920581 IC50 0.055 nM
Cc1cc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)ncc1C#N CHEMBL3948378 IC50 0.055 nM
CN(c1ncccc1C#N)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3926059 IC50 0.055 nM
CN(c1ccc(-c2nnn[nH]2)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3945908 IC50 0.055 nM
C#Cc1ccc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)nc1 CHEMBL3960416 IC50 0.055 nM
CN(c1ccc2nc[nH]c2n1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3934942 IC50 0.055 nM
CN(c1ccc2[nH]c(=O)[nH]c2n1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3962448 IC50 0.055 nM
COC(=O)c1ccc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)nc1 CHEMBL3976708 IC50 0.055 nM
CN(c1ccc(C(=O)NC2CC2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3902542 IC50 0.055 nM
CN(c1ccc(C(=O)N[C@H](CO)c2ccccc2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3984793 IC50 0.055 nM
CN(c1ccc(C(=O)N[C@@H](CO)c2ccccc2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3914972 IC50 0.055 nM
CN(c1ccc(C(=O)N[C@@H](CO)c2ccccc2)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3977452 IC50 0.055 nM
C[C@@H](NC(=O)c1ccc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)c(F)c1)c1ccccc1 CHEMBL3951623 IC50 0.055 nM
CN(c1ccc(C(=O)NC2c3ccccc3CC2O)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3939312 IC50 0.055 nM
CN(c1ccc(C(=O)Nc2cccc(Cl)c2)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3911346 IC50 0.055 nM
CN(c1ccc(C(=O)NCc2ccccc2)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3933796 IC50 0.055 nM
CN(c1ccc(C(=O)NCCO)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3902351 IC50 0.055 nM
CN(c1ccc(C(=O)Nc2ccccc2F)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3906692 IC50 0.055 nM
CN(c1ccc(C(=O)NC(CO)c2ccc(Cl)cc2)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3896837 IC50 0.055 nM
CN(c1ccc(C(=O)NC[C@H](O)c2ccccc2)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3914438 IC50 0.055 nM
CN(c1ccc(C(=O)N[C@H]2c3ccccc3C[C@@H]2O)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3914676 IC50 0.055 nM
CN(c1c(F)cc(C(=O)N[C@H](CO)c2ccccc2)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3890208 IC50 0.055 nM
COC[C@@H](NC(=O)c1cc(F)c(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)c(F)c1)c1ccccc1 CHEMBL3956882 IC50 0.055 nM
CCS(=O)(=O)Nc1ccc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)nc1 CHEMBL3982255 IC50 0.055 nM
CN(c1ccc(NS(=O)(=O)c2ccc(F)cc2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3944822 IC50 0.055 nM
CN(c1ccc(S(=O)(=O)NC2CC2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3917906 IC50 0.055 nM
CN(c1ccc(S(=O)(=O)NC[C@@H]2CCCO2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3905754 IC50 0.055 nM
CN(c1ccc(S(=O)(=O)NC2COC2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3930305 IC50 0.055 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)c(O)cc1OC(F)F)c1cnn2cccnc12 CHEMBL4789075 Ki 0.057 nM
CC(C)CS(=O)(=O)N1CCC[C@H](Nc2ncncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665179 IC50 0.0581 nM
CC(C)CS(=O)(=O)N1CCC[C@H](Nc2nc(N3CCN(C)CC3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665214 IC50 0.0585 nM
CN1CCN(CCCN2CCC(n3cc(NC(=O)c4c(N)nn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)C1=O CHEMBL3949394 Ki 0.06 nM
CN1CCN(c2ncc(-c3cnc4[nH]ccc4n3)c(N[C@H]3CCCN(S(C)(=O)=O)C3)n2)CC1 CHEMBL3335699 IC50 0.0603 nM
CC(C)CS(=O)(=O)N1CCC[C@H](Nc2nc(S(C)(=O)=O)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665182 IC50 0.0646 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(NCCO)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665192 IC50 0.0668 nM
CCCS(=O)(=O)N1C[C@@H](C)C[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665142 IC50 0.0676 nM
CC(C)CS(=O)(=O)N1C[C@@H](C)C[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3335692 IC50 0.07 nM
Nc1nn2cccnc2c1C(=O)Nc1cn([C@H]2C[C@@H](N)C2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3901134 Ki 0.07 nM
CN(C)[C@@H]1CCN(c2ncc(-c3cnc4[nH]ccc4n3)c(N[C@H]3CCCN(S(C)(=O)=O)C3)n2)C1 CHEMBL3665213 IC50 0.0708 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL4744172 Ki 0.071 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)ccc1OC(F)F)c1cnc2cccnn12 CHEMBL4793262 Ki 0.071 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(N)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3335694 IC50 0.0713 nM
COc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(C)(=O)=O)C2)n1 CHEMBL3665189 IC50 0.0717 nM
COCCNc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(C)(=O)=O)C2)n1 CHEMBL3665193 IC50 0.0763 nM
CSc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(=O)(=O)CC(C)C)C2)n1 CHEMBL3665183 IC50 0.0764 nM
CC(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)CC1 CHEMBL3665125 IC50 0.0765 nM
C#Cc1ccc2ncc(C(=O)Nc3c[nH]nc3-c3cc(Cl)ccc3OC(F)F)n2n1 CHEMBL4746416 Ki 0.078 nM
C[C@H]1C[C@H](Nc2nc(N3CCN(C)CC3)ncc2-c2cnc3[nH]ccc3n2)CN(S(=O)(=O)CC#N)C1 CHEMBL3665216 IC50 0.0782 nM
CC(C)CS(=O)(=O)N1CCC[C@H](Nc2nccnc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665167 IC50 0.0797 nM
CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3335688 IC50 0.0822 nM
CC(C)CS(=O)(=O)N1C[C@@H](C)C[C@H](Nc2nc(N3CCN(C)CC3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665215 IC50 0.0838 nM
CCC(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665137 IC50 0.0847 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)ccc1OC(F)F)c1snc2cccnc12 CHEMBL4788860 Ki 0.085 nM
CC(=O)N1CCCC(Nc2nc(C)ccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665145 IC50 0.0876 nM
N#CCS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3335691 IC50 0.088 nM
Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL4777342 Ki 0.088 nM
CN(c1cccc(-c2ccc3cnc(Nc4ccc(C5CCN(CC(N)=O)CC5)cc4)nn23)c1)S(C)(=O)=O CHEMBL1934340 IC50 0.09 nM
CC(C)CS(=O)(=O)N1CC[C@@H](O)[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665175 IC50 0.09 nM
CC(C)CN1CCC(n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3969253 Ki 0.09 nM
CS(=O)(=O)CCCN1CCC(n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3979537 Ki 0.09 nM
CC(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665120 IC50 0.0926 nM
COC(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665121 IC50 0.0986 nM
N#CC[C@@H](C1CCCC1)n1cc(-c2nc(Nc3ccc(C4CCNCC4)cc3)nc3[nH]ccc23)cn1 CHEMBL4743499 IC50 0.099 nM
Cc1ccc(Cl)cc1-c1nn(C)cc1NC(=O)c1cnn2ccc(N)nc12 CHEMBL2178805 Ki 0.1 nM
Cn1cc(NC(=O)c2cnn3ccc(N)nc23)c(-c2cc(Cl)ccc2Cl)n1 CHEMBL2178804 Ki 0.1 nM
Nc1ccn2ncc(C(=O)Nc3c[nH]nc3-c3cc(Cl)ccc3Cl)c2n1 CHEMBL3670393 Ki 0.1 nM
CC(F)(F)C(=O)N1CC[C@@](CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)nc3)n2)[C@@H](F)C1 CHEMBL3972665 IC50 0.1 nM
N#CC[C@@]1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(C(=O)OCC(F)F)C[C@@H]1F CHEMBL3965448 IC50 0.1 nM
CN(C)C(=O)CCCN1CCC(n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3971636 Ki 0.1 nM
CCCCN(C)CC#Cc1nc(-c2cc(Cl)ccc2OC(F)F)c(NC(=O)c2cnn3cccnc23)s1 CHEMBL3946275 Ki 0.1 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCC(CO)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3964279 Ki 0.1 nM
Cc1ccn2ncc(C(=O)Nc3c[nH]nc3-c3cc(Cl)ccc3OC(F)F)c2n1 CHEMBL4760406 Ki 0.1 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(N3CCOCC3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3335698 IC50 0.1026 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@@H](OP(=O)(O)O)C2)CC1 CHEMBL3652410 IC50 0.106 nM
COC1CCN(c2ncc(-c3cnc4[nH]ccc4n3)c(N[C@H]3CCCN(S(C)(=O)=O)C3)n2)CC1 CHEMBL3665197 IC50 0.1067 nM
CC(C)CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3335689 IC50 0.1079 nM
CN1CCC(Nc2ncc(-c3cnc4[nH]ccc4n3)c(N[C@H]3CCCN(S(C)(=O)=O)C3)n2)CC1 CHEMBL3665201 IC50 0.1084 nM
CN1CCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)CC1 CHEMBL3652405 IC50 0.109 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCOCC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3912167 Ki 0.11 nM
CN(C)S(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665177 IC50 0.1115 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(N3CCC(CC(=O)O)CC3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665209 IC50 0.1131 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.115 nM
CCOP(=O)(OCC)O[C@@H]1CCCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 CHEMBL3652409 IC50 0.116 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(CCCO)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3912800 Ki 0.12 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCC(F)(F)C2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3897112 Ki 0.12 nM
CCCC(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665138 IC50 0.1214 nM
CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]cc(C#N)c3n2)C1 CHEMBL3665171 IC50 0.1236 nM
CCC1CC(NS(=O)(=O)C2CC2)CC1c1ncc2cnc3[nH]ccc3n12 CHEMBL1992073 pKi 0.1259 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@@H](OC(=O)C(C)(C)C)C2)CC1 CHEMBL3652403 IC50 0.129 nM
CS(=O)(=O)N1CCC[C@H](Nc2[nH]c(=O)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3335695 IC50 0.1294 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2C[C@H]3CN(CC4CC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3950143 Ki 0.13 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(CCCN3CCCC3=O)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3976610 Ki 0.13 nM
O=C(Nc1cn(C2CCN(CCCN3CCS(=O)(=O)CC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3971137 Ki 0.13 nM
CC(=O)N1CCC(CN2CCC(n3cc(NC(=O)c4c(N)nn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3914617 Ki 0.13 nM
CCOC(=O)CCCN1CCC(n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3898055 Ki 0.13 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CC[C@@H](O)C2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL4108482 Ki 0.13 nM
N#CCCn1cc(-c2nc(Nc3ccc(C4CCNCC4)cc3)nc3[nH]ccc23)cn1 CHEMBL4753959 IC50 0.13 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(Cl)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665190 IC50 0.1314 nM
Cc1ccc(-c2cnc3[nH]ccc3n2)c(NC2CCCN(S(=O)(=O)CC(C)(C)C)C2)n1 CHEMBL3665150 IC50 0.1338 nM
CN(C)c1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(C)(=O)=O)C2)n1 CHEMBL3665186 IC50 0.1373 nM
CN(C)C1CCN(c2ncc(-c3cnc4[nH]ccc4n3)c(N[C@H]3CCCN(S(C)(=O)=O)C3)n2)CC1 CHEMBL3665203 IC50 0.1373 nM
CSc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(C)(=O)=O)C2)n1 CHEMBL3665185 IC50 0.139 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(CCCC(=O)N3CCOCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3909533 Ki 0.14 nM
O=C(Nc1c[nH]nc1-c1cc2ccccc2cc1OC(F)F)c1cnn2cccnc12 CHEMBL4745474 Ki 0.14 nM
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3nc(Nc4ccc(C(=O)NCCCCOc5ccc(C6CCC(=O)NC6=O)cc5)cc4)nc4[nH]ccc34)cn2)C1 CHEMBL5082136 Kd 0.14 nM
C[C@H]1C[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)CN(S(C)(=O)=O)C1 CHEMBL3665141 IC50 0.1401 nM
CCOc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(C)(=O)=O)C2)n1 CHEMBL3665191 IC50 0.1413 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(NC3CCC(C#N)CC3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665207 IC50 0.1455 nM
CC(=O)N1CCCC(Nc2nc(C)ccc2-c2cnc3[nH]cc(Cl)c3n2)C1 CHEMBL3639640 IC50 0.1466 nM
NS(=O)(=O)c1cc(Cl)c(Nc2nc3ccncc3c3c(=O)[nH]ccc23)c(Cl)c1 CHEMBL3126350 IC50 0.15 nM
NC(=O)CCN1CCC(n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3921617 Ki 0.15 nM
CN1CCCC(n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3894688 Ki 0.15 nM
CN1C[C@H]2C[C@@H]1CN2C(=O)Cn1cc(NC(=O)c2c(N)nn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL4111927 Ki 0.15 nM
O=C(Nc1cn(Cc2cn(C3CCN(C4CCOC4)CC3)nn2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3956152 Ki 0.15 nM
CCCn1cc(-c2nc(Nc3ccc(NC(=O)CCCCCCC(=O)NO)cc3)nc3[nH]ccc23)cn1 CHEMBL4243458 IC50 0.15 nM
N#CC[C@H](C1CCCC1)n1cc(-c2nc(Nc3ccc(C4CCNCC4)cc3)nc3[nH]ccc23)cn1 CHEMBL4750568 IC50 0.15 nM
CC(C)CC(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665140 IC50 0.1532 nM
Cc1ccc(-c2cnc3[nH]cc(Cl)c3n2)c(NC2CCCN(S(=O)(=O)CC3CC3)C2)n1 CHEMBL3665153 IC50 0.1543 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(CCCNC(=O)c3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3935850 Ki 0.16 nM
O=C(Nc1c[nH]nc1-c1c(OC(F)F)ccc(Cl)c1F)c1cnn2cccnc12 CHEMBL4756876 Ki 0.16 nM
COc1cc(O)c(Cl)cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12 CHEMBL4740223 Ki 0.16 nM
CCS(=O)(=O)N1CCCC(Nc2nc(C)ccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665148 IC50 0.1612 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(NCCN)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665198 IC50 0.1665 nM
Cc1ccc(-c2cnc3[nH]ccc3n2)c(NC2CCCN(S(=O)(=O)CC3CC3)C2)n1 CHEMBL3665149 IC50 0.1669 nM
CC(C)C(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665139 IC50 0.1684 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(N3CC[C@H](O)C3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665205 IC50 0.1694 nM
COc1ccccc1-c1ccc2cnc(Nc3ccc(C(=O)N4CCOCC4)cc3)nn12 CHEMBL1923571 IC50 0.17 nM
COc1ccccc1-c1ccc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nn12 CHEMBL1822515 IC50 0.17 nM
CN(Cc1cccc(Br)c1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3931819 Ki 0.17 nM
CC(=O)N1CCC(N2CCC(n3cc(NC(=O)c4c(N)nn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3904335 Ki 0.17 nM
CC(=O)NCCCN1CCC(n2cc(NC(=O)/C(C(=N)N)=C3\N=CC=CN3)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3927535 Ki 0.17 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCCNCC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3917854 Ki 0.17 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)ccc1OC(F)F)c1cncc2scnc12 CHEMBL4780070 Ki 0.17 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(N3CCN(c4ccccn4)CC3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665208 IC50 0.1751 nM
CC(C)(O)CNc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(C)(=O)=O)C2)n1 CHEMBL3665195 IC50 0.1769 nM
CC(C)(C)[C@@H](NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N1CC(C#N)C1 CHEMBL2325895 Kd 0.18 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(CCCC(=O)N3CCCCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3976050 Ki 0.18 nM
NC(=O)CCCN1CCC(n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3937077 Ki 0.18 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(CCCC(=O)NCc3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3980959 Ki 0.18 nM
CN1CCC(n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3937878 Ki 0.18 nM
O=C(Nc1cn(CC(=O)N2CCC(O)(c3ccncc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3897993 Ki 0.18 nM
CN[C@H]1C[C@@H](n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3977237 Ki 0.18 nM
CCN(Cc1ccnc(Cl)c1)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3976701 Ki 0.18 nM
Cc1cc(Nc2nc([C@@H](O)c3ccc(F)cc3)nc3ccccc23)n[nH]1 CHEMBL3939800 Kd 0.18 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(N3CC[C@@H](O)C3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3335697 IC50 0.1804 nM
CS(=O)(=O)N1CCC[C@H](Nc2ncncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3335693 IC50 0.1806 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCNCC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3903218 Ki 0.19 nM
O=C(CCCN1CCC(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1)NC1CCOCC1 CHEMBL3984681 Ki 0.19 nM
CCNC(=O)CCCN1CCC(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3983381 Ki 0.19 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(CCCN3CCNC3=O)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3912643 Ki 0.19 nM
O=C(Nc1c[nH]nc1-c1cc(F)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL4798728 Ki 0.19 nM
CCc1ccc(OC(F)F)c(-c2n[nH]cc2NC(=O)c2cnn3cccnc23)c1 CHEMBL4757833 Ki 0.19 nM
CC(C)CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3cc[nH]c3n2)C1 CHEMBL3665168 IC50 0.1915 nM
CN(C)CCNc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(C)(=O)=O)C2)n1 CHEMBL3665211 IC50 0.1921 nM
O=c1[nH]ccc2c3[nH]c(-c4c(F)cccc4Cl)nc3c3ccc(F)cc3c12 CHEMBL272424 IC50 0.2 nM
C[C@@H](Nc1cc(-c2c(N)nn3cccnc23)ncn1)c1ccc(F)cc1 CHEMBL583895 IC50 0.2 nM
COc1cc(Nc2ncc3ccc(-c4ccccc4)n3n2)cc(OC)c1OC CHEMBL1822511 IC50 0.2 nM
O=c1[nH]ccc2c(Nc3c(Cl)cc(C(O)C(F)F)cc3Cl)nc3ccncc3c12 CHEMBL3126349 IC50 0.2 nM
CC(C)(C)OC(=O)N1CC[C@](CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)[C@H](F)C1 CHEMBL4106834 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CCC(NCC(F)(F)F)CC1 CHEMBL3947540 IC50 0.2 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(NCc2ccccc2)CC1 CHEMBL3959005 IC50 0.2 nM
CNC(=O)CCCN1CCC(n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3900499 Ki 0.2 nM
CN1CC[C@H](n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3890200 Ki 0.2 nM
Nc1nn2cccnc2c1C(=O)Nc1cn([C@H]2CCNC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3934335 Ki 0.2 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CC[C@H](O)C2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3938660 Ki 0.2 nM
O=C(Nc1cn(CCNCc2cccc(O)c2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3924016 Ki 0.2 nM
O=C(Nc1cn(CC(=O)N2CCC(C(=O)O)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3983256 Ki 0.2 nM
C[C@](O)(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)cc1)C(F)F CHEMBL4113249 IC50 0.2 nM
C[C@@](O)(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)cc1)C(F)F CHEMBL4112743 IC50 0.2 nM
CN(C)C(=O)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL4109943 IC50 0.2 nM
COc1cc2[nH]ncc2cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12 CHEMBL4755725 Ki 0.2 nM
NCCn1cc(NC(=O)c2c(N)nn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3933199 Ki 0.21 nM
CN[C@@H]1CCC[C@H](n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL4107920 Ki 0.21 nM
O=C(Nc1cn(CCNCc2ccccc2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3921497 Ki 0.21 nM
CCN1CCN(c2ncc(-c3cnc4[nH]ccc4n3)c(N[C@H]3CCCN(S(C)(=O)=O)C3)n2)CC1 CHEMBL3665212 IC50 0.2125 nM
C[C@H]1C[C@H](Nc2nc(N3CCN(C)CC3)ncc2-c2cnc3[nH]ccc3n2)CN(S(C)(=O)=O)C1 CHEMBL3665217 IC50 0.2168 nM
N#CCC1(N2CCC[C@H](Nc3ncccc3-c3cnc4[nH]ccc4n3)C2)COC1 CHEMBL3665220 IC50 0.2185 nM
CS(=O)(=O)Nc1cccc(-c2ccc3cnc(Nc4ccc(C5CCN(CC(N)=O)CC5)cc4)nn23)c1 CHEMBL1934339 IC50 0.22 nM
CS(=O)(=O)c1ccc(-c2ccc3cnc(Nc4ccc(C5CCN(CC(N)=O)CC5)cc4)nn23)cc1 CHEMBL1934342 IC50 0.22 nM
CN1C[C@@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@]2(c2ccccc2)C1 CHEMBL4112986 Ki 0.22 nM
O=C(Nc1cn(C2CCN(CCCC(=O)N3CCOCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3976064 Ki 0.22 nM
COCCN1CCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3932570 Ki 0.22 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCC(O)(Cc3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3940032 Ki 0.22 nM
CC(C)(C)NS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665178 IC50 0.2215 nM
CC(C)S(=O)(=O)N1C[C@@H](C)C[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665144 IC50 0.2226 nM
CSc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(C(=O)CC#N)C2)n1 CHEMBL3665194 IC50 0.223 nM
COc1ccccc1-c1ccc2cnc(Nc3ccc(N4CCOCC4)cc3)nn12 CHEMBL1923573 IC50 0.23 nM
CN(Cc1ccc(C(C)(C)C)cc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3958691 Ki 0.23 nM
CN1CCN(CCCN2CCC(n3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)C1=O CHEMBL3941957 Ki 0.23 nM
CN1CC[C@@H](n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL4108502 Ki 0.23 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCOC(CO)C2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3979963 Ki 0.23 nM
O=C(Nc1cn(CCNCc2ccc(O)cc2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3901497 Ki 0.23 nM
C[C@@H](NCCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1)c1ccccc1 CHEMBL4107017 Ki 0.23 nM
CN1CCC(n2cc(Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)nn2)CC1 CHEMBL3984799 Ki 0.23 nM
CSc1ccc(Cl)cc1-c1nn(C)cc1NC(=O)c1cnn2cccnc12 CHEMBL4750979 Ki 0.23 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)ccc1SC(F)F)c1cnn2cccnc12 CHEMBL4778284 Ki 0.23 nM
N#CCC(N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1)C(F)(F)F CHEMBL3665223 IC50 0.2305 nM
O=C(Nc1cn(C2CCN(CCCN3CCCC3=O)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3974801 Ki 0.24 nM
O=C(Nc1cn(C2CCN(CCCN3CCSCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3960068 Ki 0.24 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCN(CCO)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3925958 Ki 0.24 nM
CCS(=O)(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665133 IC50 0.2469 nM
CN(C)C1CCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3937927 Ki 0.25 nM
NC(=O)CCCN1CCC(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3985698 Ki 0.25 nM
COc1cc(-c2cnc3cccc(-c4cc(F)c(CN5CCS(=O)(=O)CC5)c(F)c4)c3n2)ccc1OCCCN1CCOCC1 CHEMBL4634979 pIC50 0.2512 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(N3CCS(=O)(=O)CC3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665196 IC50 0.2551 nM
CCCCCC(CC#N)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL3953929 IC50 0.26 nM
CN1CCC2CN(C(=O)Cn3cc(NC(=O)c4c(N)nn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CCC21 CHEMBL3892526 Ki 0.26 nM
CN(C)C1CN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3932430 Ki 0.26 nM
O=C(Nc1cn(C2CCN(CCCN3CCOCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3894548 Ki 0.26 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(CCCN3CCN(Cc4ccccc4)C3=O)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3903629 Ki 0.26 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCC(O)(c3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3893713 Ki 0.26 nM
O=C(Nc1cn(Cc2cn(C3CCN(C4CCOCC4)CC3)nn2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3948039 Ki 0.26 nM
C=CCCn1cc(-c2nc(Nc3ccc(C4CCNCC4)cc3)nc3[nH]ccc23)cn1 CHEMBL4745155 IC50 0.26 nM
NC(=O)CN1CCC(c2ccc(Nc3ncc4ccc(-c5cccc(CO)c5)n4n3)cc2)CC1 CHEMBL1934341 IC50 0.27 nM
CN(c1ccc(-c2cccn3nc(Nc4ccc(CN5CCS(=O)(=O)CC5)cc4)nc23)cc1)S(C)(=O)=O CHEMBL3642343 IC50 0.27 nM
O=C(CCCN1CCC(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1)NC1COC1 CHEMBL3914878 Ki 0.27 nM
N#Cc1ccc(OC(F)F)c(-c2n[nH]cc2NC(=O)c2cnn3cccnc23)c1 CHEMBL4784721 Ki 0.27 nM
C[C@H](Nc1cc(-c2cnn(C)c2)cc(Nc2cnccn2)n1)c1ccc(F)cc1 CHEMBL4303389 IC50 0.27 nM
CN1CC2CN(C(=O)Cn3cc(NC(=O)c4c(N)nn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2C1 CHEMBL3909568 Ki 0.28 nM
CN(C)CC#Cc1nc(-c2cc(Cl)ccc2OC(F)F)c(NC(=O)c2cnn3cccnc23)s1 CHEMBL3970487 Ki 0.28 nM
O=C(Nc1cn(CCNCc2ccccc2O)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3910553 Ki 0.28 nM
Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2C2CC2)n1 CHEMBL4756764 Ki 0.28 nM
CNC(=O)CCCN1CCC(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3913141 Ki 0.29 nM
N#CC1(c2ccccc2)CCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3934963 Ki 0.29 nM
COc1ccc(Cl)c(F)c1-c1n[nH]cc1NC(=O)c1cnn2cccnc12 CHEMBL4794915 Ki 0.29 nM
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3ncnc4[nH]ccc34)cn2)C1 CHEMBL2105759 IC50 0.29 nM
COc1ccc(-c2ccc3cnc(Nc4ccc(N5CCN(C)CC5)cc4)nn23)cn1 CHEMBL1923588 IC50 0.3 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1n1cnc2cnc3[nH]ccc3c21 CHEMBL2152297 Ki 0.3 nM
Cc1ccc(C)c(-c2nn(C)cc2NC(=O)c2cnn3ccc(N)nc23)c1 CHEMBL2178803 Ki 0.3 nM
COc1ccc(Cl)cc1-c1nn(C)cc1NC(=O)c1cnn2cccnc12 CHEMBL2178801 Ki 0.3 nM
CN1CCN(c2ccc(Nc3nc4cccc(-c5ccc(S(C)(=O)=O)cc5)n4n3)cc2)CC1 CHEMBL2414547 Ki 0.3 nM
CCCCC(CC#N)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL3919101 IC50 0.3 nM
CCN1CC2CN(C(=O)Cn3cc(NC(=O)c4c(N)nn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2C1 CHEMBL3960474 Ki 0.3 nM
CCN1CCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3912892 Ki 0.3 nM
C[C@H](NCCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1)c1ccccc1 CHEMBL3897920 Ki 0.3 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)c3ccc(F)cc3)C4)n[nH]c2c1 CHEMBL3644618 IC50 0.3 nM
C[C@H](c1ccc(F)cn1)n1c(=O)[nH]c2cnc(-c3cnc4ccc(F)cn34)nc21 CHEMBL4536396 IC50 0.3 nM
Cc1cc2cnc3[nH]ccc3c2n1[C@H]1CN(C(=O)CC#N)CC[C@H]1C CHEMBL5284762 IC50 0.3 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1n1ccc2cnc3[nH]ccc3c21 CHEMBL5281283 IC50 0.3 nM
CN(Cc1ccc(Cl)c(Cl)c1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3937195 Ki 0.31 nM
Nc1nn2cccnc2c1C(=O)Nc1cn([C@@H]2CCNC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL4114441 Ki 0.31 nM
CSc1ccc(CNCCn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)cc1 CHEMBL3935161 Ki 0.31 nM
CCCS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3cc[nH]c3n2)C1 CHEMBL3665159 IC50 0.3102 nM
OCCn1cc(Nc2ncc(Cl)c(NCc3cc(F)ccc3F)n2)cn1 CHEMBL4635876 pIC50 0.3162 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CC3CNCC3C2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3936541 Ki 0.32 nM
N=C(N)CCCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3924451 Ki 0.32 nM
CSCCNCCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3958243 Ki 0.32 nM
CN1CCN(c2ccc(Nc3ncc4ccc(-c5cccc(S(=O)(=O)NC(C)(C)C)c5)n4n3)cc2)CC1 CHEMBL1923585 IC50 0.33 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2C[C@H]3CN(CC4CCC(F)(F)CC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3963779 Ki 0.33 nM
O=C1CCC(Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)O1 CHEMBL3910212 Ki 0.33 nM
Cc1ccc(OC(F)F)c(-c2n[nH]cc2NC(=O)c2cnn3cccnc23)c1 CHEMBL4760135 Ki 0.34 nM
COc1cc2ccccc2cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12 CHEMBL4742382 Ki 0.34 nM
CCCS(=O)(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665134 IC50 0.3428 nM
COc1ccccc1-c1ccc2cnc(Nc3cccc(N4CCOCC4)c3)nn12 CHEMBL1923575 IC50 0.35 nM
COc1ccccc1-c1ccc2cnc(Nc3ccc(N4CCN(C)CC4)c(F)c3)nn12 CHEMBL1923583 IC50 0.35 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(CCOCc3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3920777 Ki 0.35 nM
C[C@H](O)CN1CCN(c2ccc(Nc3ncc4ccc(-c5cccc(S(=O)(=O)NC(C)(C)C)c5)n4n3)cc2F)CC1 CHEMBL1923580 IC50 0.36 nM
CN1C[C@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@@]2(c2ccccc2)C1 CHEMBL3905567 Ki 0.36 nM
CN(C)C1CCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3959924 Ki 0.36 nM
CN1CCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3926009 Ki 0.36 nM
CCN(Cc1cccnc1)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3915560 Ki 0.36 nM
O=C(O)CCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3951874 Ki 0.36 nM
COc1ccc(Cl)cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12 CHEMBL4800012 Ki 0.36 nM
O=C(Nc1cn(CC(=O)N2CC=CCC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3934709 Ki 0.37 nM
CC(=O)NCCCN1CCC(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3946737 Ki 0.38 nM
O=C(Nc1cn(CC(=O)N2CCC(O)(c3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3953947 Ki 0.38 nM
CN(C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1)C1(CO)CC1 CHEMBL3939892 Ki 0.38 nM
CN(C)c1ncc(-c2cnc3[nH]cc(C#N)c3n2)c(N[C@H]2CCCN(S(C)(=O)=O)C2)n1 CHEMBL3665187 IC50 0.3889 nM
CN(CCO)C1CCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3889937 Ki 0.39 nM
CNC(=O)CCN1CCC(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3899968 Ki 0.39 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCN(CC3CC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3984406 Ki 0.39 nM
CCN(Cc1ccnc(C)c1)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3914623 Ki 0.39 nM
N=C(N)CCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3909090 Ki 0.39 nM
O=C(Nc1cn(CCNCc2ccccn2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3965157 Ki 0.39 nM
O=C(Nc1cn(CCN[C@H]2CCOC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3909091 Ki 0.39 nM
NC(=O)c1cnc(N[C@H](C2CC2)C(F)(F)F)c2c1[nH]c1cc(-c3cnc(N)nc3)ccc12 CHEMBL1835153 IC50 0.4 nM
Cn1cc(-c2ccc3c(c2)[nH]c2c(C(N)=O)cnc(N[C@H](C4CC4)C(F)(F)F)c23)cn1 CHEMBL1835142 IC50 0.4 nM
COc1ccc(-c2ccc3cnc(Nc4ccc(N5CCN(C)CC5)c(F)c4)nn23)cn1 CHEMBL1923589 IC50 0.4 nM
COc1ccc(-c2ccc3cnc(Nc4ccc(N5CCN(C)CC5)c(Cl)c4)nn23)cn1 CHEMBL1923590 IC50 0.4 nM
Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2Cl)n1 CHEMBL2178799 Ki 0.4 nM
CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4ccc(C(=O)N5CCOCC5)cc4)nc23)cc1 CHEMBL2414535 Ki 0.4 nM
COc1ccc(Cl)cc1-c1nc(C)sc1NC(=O)c1cnn2cccnc12 CHEMBL3667519 Ki 0.4 nM
CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4cccc(N5CCOCC5)c4)nc23)cc1 CHEMBL2062802 IC50 0.4 nM
CN(C)Cc1ccc(-c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)cc1 CHEMBL3946308 Ki 0.4 nM
O=C(Nc1cn(CC2(O)CCCC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3971083 Ki 0.4 nM
O=C(Nc1cn(CCNCc2ccncc2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3928249 Ki 0.4 nM
O=C(Nc1cn(CCN[C@@H]2CCOC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL4110635 Ki 0.4 nM
COC(C)(C)c1ccc(Nc2nn([C@@H]3COCC[C@H]3C#N)cc2C(N)=O)cc1 CHEMBL3920418 IC50 0.4 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Cl)[nH]n1 CHEMBL1231124 IC50 0.4 nM
CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4cccc(C5CCN(CC(N)=O)CC5)c4)nc23)cc1 CHEMBL3642405 IC50 0.41 nM
CN(C)C1CCN(C(=O)c2ccc(-c3nc(-c4cc(Cl)ccc4OC(F)F)c(NC(=O)c4cnn5cccnc45)s3)cc2)CC1 CHEMBL3921881 Ki 0.41 nM
CN(CCCN1CCC(n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1)C(=O)c1ccccc1 CHEMBL3964224 Ki 0.42 nM
O[C@]12C[C@@H]3C[C@H](C1)[C@H](Nc1c(-c4cn[nH]c4)cnc4[nH]ccc14)[C@@H](C3)C2 CHEMBL5422793 IC50 0.423 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(Cc3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3903778 Ki 0.43 nM
CN(C)CC(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3914779 Ki 0.43 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCNCC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3907431 Ki 0.44 nM
N#CC1(c2ccccc2)CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3973547 Ki 0.45 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cc3)c(C#N)cc2F)n[nH]1 CHEMBL1774055 Ki 0.45 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)ccc1OC1CC1)c1cnn2cccnc12 CHEMBL4762168 Ki 0.45 nM
CS(=O)(=O)CCN1CCC(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)CC1 CHEMBL3642411 IC50 0.46 nM
O=C(Nc1cn(C2CCNCC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3985468 Ki 0.46 nM
CS(=O)(=O)N1CCC(CN2C[C@@H]3CN(C(=O)Cn4cc(NC(=O)c5cnn6cccnc56)c(-c5cc(Cl)ccc5OC(F)F)n4)C[C@@H]3C2)CC1 CHEMBL3890487 Ki 0.46 nM
C[C@@H]1CN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C[C@H](C)N1 CHEMBL3934286 Ki 0.46 nM
O=C(Nc1cn(CC(=O)N2CCC[C@H]2CO)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3929573 Ki 0.46 nM
COC(=O)[C@@H](N)CCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3915304 Ki 0.46 nM
CC(C)CS(=O)(=O)N1C[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C[C@H](C(F)(F)F)C1 CHEMBL3665219 IC50 0.4635 nM
COc1ccccc1-c1ccc2cnc(Nc3ccc(N4CCN(C[C@H](C)O)CC4)cc3)nn12 CHEMBL1923574 IC50 0.47 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCC(Oc3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3896005 Ki 0.47 nM
CCOC(=O)[C@@H](N)CCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3909987 Ki 0.47 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@H](O)C(F)(F)F)cc2)n1 CHEMBL4089118 IC50 0.47 nM
CCn1c(C(=O)N(C2CC2)C2CC2)cc2c3c(ncn3C)c(Nc3cc(C)n(C)n3)nc21 CHEMBL3545215 Kd 0.48 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(CCCCOCCc3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3970566 Ki 0.48 nM
CN1C[C@@H]2C[C@H]1CN2C(=O)Cn1cc(NC(=O)c2c(N)nn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3949658 Ki 0.48 nM
Fc1cc(-c2cccc3ncc(-c4cnn(C5CCNCC5)c4)nc23)cc(F)c1CN1CCOCC1 CHEMBL1092926 IC50 0.48 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CC4CCC(F)(F)CC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3957547 Ki 0.49 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)ccc1OC(F)(F)F)c1cnn2cccnc12 CHEMBL4790609 Ki 0.49 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)ccc1OC(F)F)c1cncc2c[nH]nc12 CHEMBL4760562 Ki 0.49 nM
CCC[C@@H](Nc1cc(-c2c(N)nn3cccnc23)ncn1)c1ccc(F)cc1 CHEMBL584944 IC50 0.5 nM
Oc1ccc(C2Nc3ccccc3-c3ccnc4[nH]cc2c34)cc1F CHEMBL591096 Ki 0.5 nM
COc1ccc(Nc2ncc3ccc(-c4ccccc4OC)n3n2)cc1 CHEMBL1923570 IC50 0.5 nM
COc1ccccc1-c1ccc2cnc(Nc3ccc(N4CCN(C[C@H](C)O)CC4)c(F)c3)nn12 CHEMBL1923579 IC50 0.5 nM
COc1ccccc1-c1ccc2cnc(Nc3ccc(N4CCN(C)CC4)c(Cl)c3)nn12 CHEMBL1923584 IC50 0.5 nM
COc1ccc(-c2ccc3cnc(Nc4ccc(C5CCN(C[C@H](C)O)CC5)cc4)nn23)cn1 CHEMBL1923594 IC50 0.5 nM
N#C[C@H]1CCN(C(=O)[C@H](NC(=O)c2c[nH]c3ncc(C4CC4)nc23)C2CC2)C1 CHEMBL2325898 IC50 0.5 nM
CC(C)n1cc(-c2cccn3nc(Nc4ccc(C(=O)O)cc4)nc23)cn1 CHEMBL2414542 Ki 0.5 nM
O=C(O)c1ccc(Nc2nc3c(-c4cnn(C5CCCCC5)c4)cccn3n2)cc1 CHEMBL2414541 Ki 0.5 nM
CC(C)Cn1cc(-c2cccn3nc(Nc4ccc(C(=O)O)cc4)nc23)cn1 CHEMBL2414538 Ki 0.5 nM
CC(C)(O)c1cc(Cl)c(Nc2nc3ccncc3c3c(=O)[nH]ccc23)c(Cl)c1 CHEMBL3126347 IC50 0.5 nM
CC(C)(C)OC(=O)N1CCC(n2cc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)cn2)CC1 CHEMBL3644960 IC50 0.5 nM
COc1ccc(Cl)cc1-c1c(NC(=O)c2c(N)nn3cccnc23)cnn1CC(N)=O CHEMBL3667521 Ki 0.5 nM
Cc1cc(NC(=O)c2cnn3ccc(N)nc23)n(-c2cc(Cl)ccc2C)n1 CHEMBL3670390 Ki 0.5 nM
CN(c1ccc(C(=O)NC2c3ccccc3C[C@H]2O)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL4108544 IC50 0.5 nM
Cn1cc(-c2ccc(Nc3nn(C4(CC#N)CCN(C(=O)OCC(F)(F)F)CC4)cc3C(N)=O)cn2)cn1 CHEMBL3929513 IC50 0.5 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)CCN(C(=O)Nc2ccc(C#N)cc2)CC1 CHEMBL3922069 IC50 0.5 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CCCN4CCOC4=O)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3961393 Ki 0.5 nM
O=C(Nc1cn(CCNCc2ncco2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3935396 Ki 0.5 nM
Cn1cc(-c2ccc(Nc3nn([C@H]4COCC[C@@H]4C#N)cc3C(N)=O)cc2)cn1 CHEMBL4078799 IC50 0.5 nM
Cc1cnc(Nc2ccc(N3CCOCC3)cc2)nc1-c1cc2c(o1)CCN(C(=O)CC#N)C2 CHEMBL4590082 IC50 0.5 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL221959 IC50 0.5 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)ccc1OC(F)F)c1cncc2ccoc12 CHEMBL4778449 Ki 0.5 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@@H](C)CO)c2nc(NCCCCCN(C)C)ncc2c1 CHEMBL5075556 pIC50 0.5012 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCC(N3CC[C@H](O)C3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3942542 Ki 0.51 nM
CN(Cc1ccc(Br)cc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3900819 Ki 0.51 nM
O=C(Nc1cn(CCNCc2cccnc2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3926601 Ki 0.51 nM
CSCCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3912919 Ki 0.51 nM
Cc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1Nc1ccc(S(=O)(=O)NC(C)(C)C)cc1 CHEMBL5281221 IC50 0.51 nM
C[C@H]1C[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)CN(C2(CC#N)COC2)C1 CHEMBL3665221 IC50 0.5116 nM
CS(=O)(=O)c1cccc(-c2ccc3cnc(Nc4ccc(C5CCN(CC(N)=O)CC5)cc4)nn23)c1 CHEMBL1934343 IC50 0.52 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCC(N3CC[C@@H](O)C3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL4115299 Ki 0.52 nM
CS(=O)(=O)CCN1C[C@@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@@H]2C1 CHEMBL3904982 Ki 0.53 nM
CN(C)C[C@@H]1CCCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3975201 Ki 0.53 nM
COc1ccccc1-c1ccc2cnc(Nc3cccc(N4CCN(C[C@H](C)O)CC4)c3)nn12 CHEMBL1923577 IC50 0.54 nM
N#CC1(CN2C[C@@H]3CN(C(=O)Cn4cc(NC(=O)c5cnn6cccnc56)c(-c5cc(Cl)ccc5OC(F)F)n4)C[C@@H]3C2)CCCCC1 CHEMBL3890535 Ki 0.54 nM
CCOC(=O)CNCCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3958066 Ki 0.54 nM
CN1CCCC2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC21 CHEMBL3950981 Ki 0.54 nM
CN[C@H]1CC2OC([C@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(O)=NC4 CHEMBL3975634 IC50 0.55 nM
CS(=O)(=O)c1ccc(-c2cccc3nc(Nc4cccc(CN5CCS(=O)(=O)CC5)c4)nn23)cc1 CHEMBL3642344 IC50 0.55 nM
CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4cccc([C@@H]5CCN(CC(N)=O)C[C@@H]5O)c4)nc23)cc1 CHEMBL3642412 IC50 0.55 nM
CCCC(=O)N(C)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3974254 IC50 0.55 nM
CN(C(=O)C1(C#N)CC1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3965889 IC50 0.55 nM
CN(C(=O)CC#N)C1CCCN(c2ncnc3[nH]ccc23)C1 CHEMBL3969009 IC50 0.55 nM
CN([C@@H]1CCN(c2ncnc3[nH]ccc23)C1)S(=O)(=O)c1cccc(C#N)c1 CHEMBL3958078 IC50 0.55 nM
CN([C@@H]1CCN(c2ncnc3[nH]ccc23)C1)S(=O)(=O)c1cccc([N+](=O)[O-])c1 CHEMBL3963715 IC50 0.55 nM
CN(C(=O)Nc1cccc(C#N)c1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3979629 IC50 0.55 nM
CN(C(=O)Nc1ccc(C#N)cc1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3960213 IC50 0.55 nM
CN(C(=O)Nc1ccc(C(F)(F)F)cc1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3975430 IC50 0.55 nM
CC(C)S(=O)(=O)N(C)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3909435 IC50 0.55 nM
N#CCN(C1CCC1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3910166 IC50 0.55 nM
CN(C1CCCC1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3929901 IC50 0.55 nM
N#CCN(C1CC1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3968478 IC50 0.55 nM
C#CCN(C1CCOC1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3942396 IC50 0.55 nM
CN([C@@H]1CCN(c2ncnc3[nH]ccc23)C1)S(=O)(=O)C1CC1 CHEMBL3973113 IC50 0.55 nM
C#CCN(c1ccc(S(C)(=O)=O)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3943618 IC50 0.55 nM
CN(c1ccc(Br)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3959770 IC50 0.55 nM
CN(c1ccc([N+](=O)[O-])cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3952191 IC50 0.55 nM
Cc1cc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)nc(Cl)c1C#N CHEMBL3948936 IC50 0.55 nM
Cc1cc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)ncc1[N+](=O)[O-] CHEMBL3890701 IC50 0.55 nM
CN(c1nc(Cl)nc2ccccc12)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3949963 IC50 0.55 nM
CN(c1ncc(C#N)cc1Cl)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3890611 IC50 0.55 nM
CN(c1ccc(Cl)nn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3891047 IC50 0.55 nM
CN(c1ncc(Br)cc1C#N)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3919105 IC50 0.55 nM
CN(c1ccc(C#N)c(Cl)n1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3964318 IC50 0.55 nM
CN(c1ncc(C#N)cc1[N+](=O)[O-])[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3925815 IC50 0.55 nM
N#Cc1cnc(NC2CCN(c3ncnc4[nH]ccc34)C2)c([N+](=O)[O-])c1 CHEMBL3975440 IC50 0.55 nM
Cc1ccc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)nc1 CHEMBL3904624 IC50 0.55 nM
CN(c1ccc(C#N)cc1[N+](=O)[O-])[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3980318 IC50 0.55 nM
CN(c1c(F)cc(C#N)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3913608 IC50 0.55 nM
CN(c1ccc(C#N)cc1Br)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3924625 IC50 0.55 nM
C#CCN(c1ccc(C#N)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3964413 IC50 0.55 nM
CCOc1cnc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)cn1 CHEMBL3906422 IC50 0.55 nM
CN(c1ccc(-c2cccs2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3973893 IC50 0.55 nM
CN(c1ccncn1)[C@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3961670 IC50 0.55 nM
CN(c1ncc(C#N)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3937439 IC50 0.55 nM
CN(c1ccc(-c2nn[nH]n2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3968579 IC50 0.55 nM
CN(c1ccc2nn[nH]c2n1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3935988 IC50 0.55 nM
CN(c1ccc(C(=O)O)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3930951 IC50 0.55 nM
CN(C(=O)c1ccc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)nc1)c1ccc(F)cc1 CHEMBL3911946 IC50 0.55 nM
CN(C(=O)c1ccc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)nc1)c1ccccc1 CHEMBL3981902 IC50 0.55 nM
CN(c1ccc(C(=O)NC(CO)c2ccccc2Cl)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3985350 IC50 0.55 nM
CN(c1ccc(NS(C)(=O)=O)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3939379 IC50 0.55 nM
CC(C)S(=O)(=O)Nc1ccc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)nc1 CHEMBL3965713 IC50 0.55 nM
CNS(=O)(=O)c1ccc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)nc1 CHEMBL3902579 IC50 0.55 nM
CN(c1ccc(S(=O)(=O)NCCO)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3920398 IC50 0.55 nM
CN(c1ccc(S(=O)(=O)N2CCOCC2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3983040 IC50 0.55 nM
CN(c1ccc(S(=O)(=O)NC2CCOCC2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3928129 IC50 0.55 nM
CS(=O)(=O)CCCN1C[C@@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@@H]2C1 CHEMBL3926308 Ki 0.55 nM
N#Cc1ccc(CN2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)cc1 CHEMBL3935981 Ki 0.55 nM
O=C(Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1)NCC1(CO)CC1 CHEMBL3945218 Ki 0.55 nM
O=C(Nc1cn(CC(=O)N2CCCCC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3920142 Ki 0.55 nM
O=C(O)CNC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3937898 Ki 0.55 nM
O=C1CCC(CNCCn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)O1 CHEMBL3920178 Ki 0.55 nM
CS(=O)(=O)N1C[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C[C@H](C(F)(F)F)C1 CHEMBL3665218 IC50 0.5559 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CCCN4CCCC4=O)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3914541 Ki 0.56 nM
CN1CCN(C(=O)c2ccc(-c3nc(-c4cc(Cl)ccc4OC(F)F)c(NC(=O)c4cnn5cccnc45)s3)cc2)CC1 CHEMBL3891220 Ki 0.56 nM
COC(=O)CNCCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3985077 Ki 0.56 nM
CN(CC(C)(C)C#N)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3984319 Ki 0.56 nM
CN1CCCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3944331 Ki 0.57 nM
COCCNCCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3957231 Ki 0.57 nM
CC(C)S(=O)(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665135 IC50 0.5728 nM
CN1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3952022 Ki 0.58 nM
CC(C)CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3ccn(C)c3n2)C1 CHEMBL3665161 IC50 0.5802 nM
COCCN(C)C1CCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3914377 Ki 0.59 nM
O=C(CNCCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1)OC1CCCC1 CHEMBL3894756 Ki 0.59 nM
O=C(O)CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3908328 Ki 0.59 nM
CC[C@@H](Nc1cc(-c2c(N)nn3cccnc23)ncn1)c1ccc(F)cc1 CHEMBL569966 IC50 0.6 nM
CC(C)[C@@H](Nc1cc(-c2c(N)nn3cccnc23)ncn1)c1ccc(F)cc1 CHEMBL570217 IC50 0.6 nM
Oc1ccc(C2Nc3ccccc3-c3ccnc4[nH]cc2c34)c(F)c1 CHEMBL602183 Ki 0.6 nM
Cc1cc(Nc2nc(N3CCN(C(=O)Cc4ccc(Cl)cc4)CC3)nn3cccc23)n[nH]1 CHEMBL1682386 IC50 0.6 nM
COc1ccccc1-c1ccc2cnc(Nc3ccc(C4CCN(C[C@H](C)O)CC4)cc3)nn12 CHEMBL1923593 IC50 0.6 nM
COc1ccccc1-c1ccc2cnc(Nc3ccc(C4CCN(CC(N)=O)CC4)cc3)nn12 CHEMBL1934335 IC50 0.6 nM
Cc1ccc(Cl)cc1-c1nn(C)cc1NC(=O)c1cnn2cccnc12 CHEMBL2178800 Ki 0.6 nM
O=C(O)c1ccc(Nc2nc3c(-c4cnn(C5CCCC5)c4)cccn3n2)cc1 CHEMBL2414540 Ki 0.6 nM
CN(C)C(=O)c1ccc(Nc2nc3c(-c4ccc(S(C)(=O)=O)cc4)cccn3n2)cc1 CHEMBL2414534 Ki 0.6 nM
CC(C)c1cccc(-c2cccc3nc(Nc4ccnc(CO)c4)nn23)c1 CHEMBL2414549 Ki 0.6 nM
COc1ccc(-c2cccc3nc(Nc4ccc(N5CCN(C)CC5)cc4)nn23)cc1 CHEMBL2414544 Ki 0.6 nM
N#C[C@H]1CCC[C@H]1Nc1nc(-c2cn[nH]c2)nc2c(=O)[nH]ccc12 CHEMBL2436944 Ki 0.6 nM
CC(O)c1cc(Cl)c(Nc2nc3ccncc3c3c(=O)[nH]ccc23)c(Cl)c1 CHEMBL3126346 IC50 0.6 nM
CN1CCN(c2cccc(Nc3nc4c(-c5ccc(N(C)S(C)(=O)=O)cc5)cccn4n3)c2)CC1 CHEMBL3642296 IC50 0.6 nM
CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4ccc(N5CCCCC5)cc4)nc23)cc1 CHEMBL3642262 IC50 0.6 nM
CN1CCN(c2ccc(Nc3nc4c(-c5ccc(N(C)S(C)(=O)=O)cc5)cccn4n3)cc2)CC1 CHEMBL3642295 IC50 0.6 nM
CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4cccc(CN5CCOCC5)c4)nc23)cc1 CHEMBL3639411 IC50 0.6 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2cccnc2F)CC1 CHEMBL3895272 IC50 0.6 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CC1 CHEMBL3935178 IC50 0.6 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(C(O)C(F)(F)F)nc3)n2)CCN(C(=O)OCC(F)(F)F)CC1 CHEMBL3984300 IC50 0.6 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(-c4cn[nH]c4)nc3)n2)CCN(C(=O)OCC(F)(F)F)CC1 CHEMBL3896068 IC50 0.6 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(Nc2ccccc2)CC1 CHEMBL3929641 IC50 0.6 nM
O=C(Nc1cn(CC(=O)N2CCN(Cc3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3951397 Ki 0.6 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@@H](O)C(F)(F)F)cc2)n1 CHEMBL4111960 IC50 0.6 nM
CC1(c2ccc(Nc3nn([C@H]4COCC[C@@H]4C#N)cc3C(N)=O)cc2)COC1 CHEMBL4113190 IC50 0.6 nM
C[C@H](c1ncc(F)cn1)n1c(=O)[nH]c2cnc(-c3cnc4ccc(F)cn34)nc21 CHEMBL4469844 IC50 0.6 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL2103743 Kd 0.6 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CC4CCC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3952029 Ki 0.61 nM
CCNC1CCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3984741 Ki 0.61 nM
O=C(Nc1cn(C/C=C/CN2CCOCC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3920894 Ki 0.61 nM
CN(C)CC(O)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3915738 Ki 0.61 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(C#N)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665204 IC50 0.6186 nM
CN(C)C(=O)N1CCC(CN2C[C@@H]3CN(C(=O)Cn4cc(NC(=O)c5cnn6cccnc56)c(-c5cc(Cl)ccc5OC(F)F)n4)C[C@@H]3C2)CC1 CHEMBL3968299 Ki 0.62 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CC4CCCCC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3971672 Ki 0.62 nM
O=C(Nc1cn(CC(=O)N2CCC[C@H]2C(O)CO)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3924226 Ki 0.62 nM
CN1CN([C@H]2CC[C@H](CN3CCCS3(=O)=O)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3984749 IC50 0.62 nM
COc1ccc(Cl)cc1-c1nn(C)cc1NC(=O)c1cncc2cccnc12 CHEMBL4795297 Ki 0.62 nM
O=C(Nc1cn(CC(=O)N2CCC(O)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3963271 Ki 0.63 nM
O=C(Nc1cn(CC(=O)N2CCC(N3CC[S+]([O-])CC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3893449 Ki 0.63 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@H]2C[C@H]3CC[C@@H](C2)N3)c2nc(N)ncc2c1 CHEMBL5076189 pIC50 0.631 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(Nc3ccncc3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665210 IC50 0.6379 nM
CC(C)(C)NS(=O)(=O)c1cccc(-c2ccc3cnc(Nc4ccc(C5CCN(CC(N)=O)CC5)cc4)nn23)c1 CHEMBL1934337 IC50 0.64 nM
CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4cccc(CN5CCS(=O)(=O)CC5)c4)nc23)cc1 CHEMBL2062807 IC50 0.64 nM
CN(CC1(C#N)CC1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3981690 Ki 0.64 nM
CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4cccc(N5CCN(CC(N)=O)CC5)c4)nc23)cc1 CHEMBL3642404 IC50 0.65 nM
O=C(Nc1cn(CC(=O)N2CCC(F)(F)C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3968315 Ki 0.65 nM
O=C(Nc1cn(Cc2cn(C3CCNCC3)nn2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3915071 Ki 0.65 nM
CC(C)(C(=O)NCC(F)(F)F)c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3699558 IC50 0.66 nM
CS(=O)(=O)c1ccc(-c2cccc3nc(Nc4ccc(CN5CCS(=O)(=O)CC5)cc4)nn23)cc1 CHEMBL3642340 IC50 0.66 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CCc4ccccc4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3901102 Ki 0.66 nM
O=C(Nc1cn([C@@H]2CCNC[C@H]2O)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL4106450 Ki 0.66 nM
CNC(=O)CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3932623 Ki 0.66 nM
CC(C)CS(=O)(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665136 IC50 0.662 nM
CN1CC[C@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC[C@H]21 CHEMBL3920824 Ki 0.67 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CCCN4C(=O)Cc5ccccc54)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3980799 Ki 0.67 nM
O=C(Nc1cn(CC(=O)N2CCC(N3CCSCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3908409 Ki 0.67 nM
CN1CC[C@@H]2[C@H](CCN2C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL4115292 Ki 0.68 nM
O=C(Nc1cn(CC(=O)N2CCN(Cc3ncco3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3947977 Ki 0.68 nM
O=C(Nc1cn(CC(O)CN2CCCCC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3983445 Ki 0.68 nM
CN(C)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3956075 Ki 0.69 nM
CN(CC(C)(F)F)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3970779 Ki 0.69 nM
O=C(Nc1sc(N2CCN(CC3CC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3959420 Ki 0.69 nM
CN1CCC(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)CC1 CHEMBL2062809 IC50 0.7 nM
COc1ccc(-c2cccn3nc(Nc4cnn(C5CCOCC5)c4)nc23)cc1 CHEMBL2414537 Ki 0.7 nM
CCn1c(C(=O)N(C2CC2)C2CC2)cc2c3c(ncn3C)c(Nc3nc(C)c(C(=O)N4CCS(=O)(=O)CC4)s3)nc21 CHEMBL3622146 IC50 0.7 nM
CS(=O)(=O)c1ccc(-c2cccc3nc(Nc4ccc(N5CCOCC5)cc4)nn23)cc1 CHEMBL3642258 IC50 0.7 nM
CN1CCN(c2ccc(Nc3nc4c(-c5ccc(CS(C)(=O)=O)cc5)cccn4n3)cc2)CC1 CHEMBL3642285 IC50 0.7 nM
Cc1cnc(Nc2ccc(N3CCOCC3)cc2)nc1-c1cc2c(o1)CCN(S(C)(=O)=O)C2 CHEMBL3940537 IC50 0.7 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(=O)N4CCOCC4)c(F)c3)n2)CC1 CHEMBL3942917 IC50 0.7 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(=O)N4CCOCC4)cc3)n2)CC1 CHEMBL3902563 IC50 0.7 nM
CC(C)(O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OCC(F)(F)F)CC3)cc2C(N)=O)cn1 CHEMBL3931250 IC50 0.7 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CC4(O)CCCCC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3979546 Ki 0.7 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CCOCc4ccc(Cl)cc4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3915326 Ki 0.7 nM
CN(CCC#N)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3964801 Ki 0.7 nM
CC(F)(F)CNC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3896662 Ki 0.7 nM
N#Cc1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL4061128 IC50 0.7 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(-n3ccnn3)cc2)n1 CHEMBL4096821 IC50 0.7 nM
Cc1cnc(Nc2ccc(N3CCC(N(C)CCO)CC3)c(F)c2)nc1-c1cnn(C(C)C)c1 CHEMBL4447631 IC50 0.7 nM
C[C@H](c1ccccc1)n1c(=O)[nH]c2cnc(-c3cnc4ccc(F)cn34)nc21 CHEMBL4450301 IC50 0.7 nM
CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4cnn(C5CCNCC5)c4)nc23)cc1 CHEMBL3644961 IC50 0.71 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CCCN4CCOCC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3981144 Ki 0.71 nM
O=C(Nc1cn(CC(=O)N2CCN(CCCO)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3940929 Ki 0.71 nM
O=C(Nc1cn(CC(O)CN2CCOCC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3894603 Ki 0.71 nM
O=C1CN(C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CCN1 CHEMBL3956898 Ki 0.71 nM
Cc1cc(Nc2nc(O[C@@H](C)c3ncc(F)cn3)c(F)c(N3CCOCC3)n2)n[nH]1 CHEMBL2381980 Ki 0.72 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CCCOC(=O)C4CCC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3951947 Ki 0.72 nM
CN(C)CCOC1CCN(C(=O)Cn2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3970998 Ki 0.72 nM
O=C(Nc1cn(CC(=O)N2CCC3(CCNC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3915865 Ki 0.72 nM
CN1CCN(c2ccc(-c3nc(-c4cc(Cl)ccc4OC(F)F)c(NC(=O)c4cnn5cccnc45)s3)cc2)CC1 CHEMBL3966147 Ki 0.72 nM
CN(C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1)C1COC1 CHEMBL3911166 Ki 0.72 nM
CC(C)S(=O)(=O)N1CCC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665132 IC50 0.7285 nM
CN1Cc2ccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)cc2C1 CHEMBL3642389 IC50 0.73 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CC4CCN(C(=O)C5CCOCC5)CC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3918538 Ki 0.73 nM
N#CCCNC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3963191 Ki 0.73 nM
O=C(O)CNC1CCN(CCn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3978749 Ki 0.73 nM
CC(C)(O)CCN1C[C@@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@@H]2C1 CHEMBL3929116 Ki 0.74 nM
O=C(Nc1cn(CC(=O)N2CCN(c3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3898868 Ki 0.74 nM
CC(C#N)CN(C)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3905788 Ki 0.74 nM
CN(C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1)C1(C#N)CC1 CHEMBL3914162 Ki 0.74 nM
CC(C)(C#N)CNC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3908154 Ki 0.74 nM
C[C@H](O)CN1CCN(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)CC1 CHEMBL3642365 IC50 0.75 nM
CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4ccc(CN5CCS(=O)(=O)CC5)cc4)nc23)cc1 CHEMBL3642339 IC50 0.75 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CC4CC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3984720 Ki 0.75 nM
CNC(=O)CN1CCC(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3954749 Ki 0.75 nM
CN(CC1=CC(=O)OC1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3948591 Ki 0.75 nM
O=C1CCC(CN2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)O1 CHEMBL3956628 Ki 0.75 nM
N#CC1(NC2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3915972 Ki 0.75 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 IC50 0.75 nM
CN(CC(F)(F)F)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3890537 Ki 0.76 nM
N#Cc1ccc(N2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)cc1 CHEMBL3970070 Ki 0.76 nM
COC(=O)CNC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3972612 Ki 0.76 nM
O=C1CC(N2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CCO1 CHEMBL3957132 Ki 0.76 nM
N#C[C@H]1CCCN(C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)C1 CHEMBL4111727 Ki 0.76 nM
COc1ccc(-c2ccc3cnc(Nc4ccc(C5CCN(CC(N)=O)CC5)cc4)nn23)cn1 CHEMBL1934338 IC50 0.77 nM
O=C(Nc1sc(-c2ccncc2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3978806 Ki 0.77 nM
COC(=O)CCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3909519 Ki 0.77 nM
O=C1CC(N2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CO1 CHEMBL3914221 Ki 0.77 nM
CCOC(=O)CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3921546 Ki 0.77 nM
CN1CCC2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC21 CHEMBL3983983 Ki 0.77 nM
CCN1C[C@@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@@H]2C1 CHEMBL3899762 Ki 0.78 nM
CN1C[C@@H]2[C@H](C1)[C@H](CO)N(C(=O)Cn1cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n1)[C@@H]2c1ccccc1 CHEMBL3942241 Ki 0.78 nM
COCCCN1C[C@@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@@H]2C1 CHEMBL3916637 Ki 0.78 nM
O=C(Nc1cn(CC(=O)N2CCC(O)(CO)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3906168 Ki 0.78 nM
O=C(Nc1cn(CC(=O)N2CC3CCCNC3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3924255 Ki 0.78 nM
COc1ccc(Cl)cc1-c1nn(C)cc1NC(=O)c1cncc2c[nH]nc12 CHEMBL4788474 Ki 0.78 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc3c(c2)CN(CC(F)(F)F)C3=O)n1 CHEMBL3699521 IC50 0.79 nM
COc1cc(F)c(Cl)cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12 CHEMBL4755407 Ki 0.79 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 0.7943 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 0.7943 nM
N#CCC(C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL2002099 pKi 0.7943 nM
CC1CCN(C(=O)CC#N)CC1c1ncc2cnc3[nH]ccc3n12 CHEMBL1966175 pKi 0.7943 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 0.7943 nM
CCc1cc(O)c(F)cc1-c1cc(NC2CCN(C(C)=O)CC2)c2nc(N)ncc2c1 CHEMBL5084542 pIC50 0.7943 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@@H](C)CO)c2nc(N)ncc2c1 CHEMBL5078647 pIC50 0.7943 nM
Oc1ccc(C2=Nc3ccccc3-c3ncnc4[nH]cc2c34)c(Cl)c1 CHEMBL603048 Ki 0.8 nM
COc1ccccc1-c1ccc2cnc(Nc3cccc(N4CCN(C)CC4)c3)nn12 CHEMBL1923576 IC50 0.8 nM
COc1cc(-c2cnc3[nH]cc(C(=O)N[C@H](C)C(=O)N4CC(C#N)C4)c3n2)cc(OC)c1OC CHEMBL2376040 IC50 0.8 nM
O=c1[nH]ccc2c(Nc3c(Cl)cc(F)cc3Cl)nc3ccncc3c12 CHEMBL3126341 IC50 0.8 nM
CN1CCN(c2cccc(Nc3nc4cccc(-c5ccc(CN6CCS(=O)(=O)CC6)cc5)n4n3)c2)CC1 CHEMBL3642303 IC50 0.8 nM
O=C(NC1CCC(O)CC1)c1cnn2ccc(NC3CCc4ccccc43)nc12 CHEMBL3960901 Ki 0.8 nM
CN(C)S(=O)(=O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1 CHEMBL3931150 IC50 0.8 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(Nc2ccc(F)cc2F)CC1 CHEMBL3904265 IC50 0.8 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc([S+]([O-])C(F)F)cc3)n2)CCC(Nc2cccc(O)c2)CC1 CHEMBL3938031 IC50 0.8 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CNC[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3931278 Ki 0.8 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CC(F)(F)F)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3922782 Ki 0.8 nM
COC(=O)CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3941118 Ki 0.8 nM
O=C(CN1CCCCC1)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3966418 Ki 0.8 nM
CCc1cc(O)ccc1-c1ccc2c(-c3ncc[nH]3)n[nH]c2c1 CHEMBL4086057 IC50 0.8 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(OC(F)F)cc2)n1 CHEMBL4102140 IC50 0.8 nM
O=c1[nH]c2cnc(-c3cnc4ccc(F)cn34)nc2n1[C@@H]1CC[C@@H](O)c2ccccc21 CHEMBL4471599 IC50 0.8 nM
CCOc1ccc(Cl)cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12 CHEMBL4781087 Ki 0.8 nM
CN1C[C@@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@@H]2C1 CHEMBL3974166 Ki 0.81 nM
CCOC(=O)N1CCC(CN2C[C@@H]3CN(C(=O)Cn4cc(NC(=O)c5cnn6cccnc56)c(-c5cc(Cl)ccc5OC(F)F)n4)C[C@@H]3C2)CC1 CHEMBL3932644 Ki 0.81 nM
CC1(O)CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3947456 Ki 0.81 nM
CN(CCC#N)C1CCC(=CCn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3933766 Ki 0.81 nM
CC(C)CCS(=O)(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665143 IC50 0.8108 nM
CC1(O)CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3929644 Ki 0.83 nM
O=C(Nc1cn(CC(=O)N2CCOC(CO)C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3962342 Ki 0.83 nM
CCCS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ncc3n2)C1 CHEMBL3665157 IC50 0.8331 nM
CC(C)CN1C[C@@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@@H]2C1 CHEMBL3903720 Ki 0.84 nM
CN(C)C1CN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3950178 Ki 0.84 nM
CN(C)C1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3921926 Ki 0.84 nM
COCCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3913842 Ki 0.84 nM
CN(CCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1)CC1CCC(=O)O1 CHEMBL3962664 Ki 0.84 nM
CN1CCN(C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1=O CHEMBL3922831 Ki 0.84 nM
CN(C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1)[C@H]1CCOC1 CHEMBL3891615 Ki 0.84 nM
N#CCCCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3964990 Ki 0.84 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CC4CCN(C(=O)OCc5ccccc5)CC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3976307 Ki 0.85 nM
CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ncc3n2)C1 CHEMBL3665156 IC50 0.8586 nM
O=C(Nc1sc(N2CC(N3CCCCC3)C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3922979 Ki 0.86 nM
CN(C)C1CCN(C(=O)C2CCN(c3nc(-c4cc(Cl)ccc4OC(F)F)c(NC(=O)c4cnn5cccnc45)s3)CC2)CC1 CHEMBL3906961 Ki 0.86 nM
CCCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3891057 Ki 0.86 nM
N#CC1CCN(C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3967830 Ki 0.86 nM
O=C(Nc1c[nH]nc1-c1ccccc1OC(F)F)c1cnn2cccnc12 CHEMBL4757212 Ki 0.86 nM
CC1(CN2C[C@@H]3CN(C(=O)Cn4cc(NC(=O)c5cnn6cccnc56)c(-c5cc(Cl)ccc5OC(F)F)n4)C[C@@H]3C2)COC1 CHEMBL3929734 Ki 0.87 nM
CN(C)CC1(c2ccccc2)CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3900004 Ki 0.87 nM
O=C(Nc1cn(CC(=O)N2CCC(N3CCNCC3=O)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3975506 Ki 0.87 nM
O=C(Nc1cn(CC(=O)N2CCC(N3CCC(O)CC3=O)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3896759 Ki 0.88 nM
O=C(Nc1cn(CC(=O)N2CCN(CC3CC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3896141 Ki 0.88 nM
O=C(Nc1cn(CC(=O)N2CCN(C3CCOC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3982408 Ki 0.88 nM
CN1CCN(C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)C(=O)C1 CHEMBL3957195 Ki 0.88 nM
O=C(Nc1cn(CC(=O)N2CCN(CCO)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3911942 Ki 0.89 nM
O=C(Nc1cn(CC(=O)N2CCC(OCCO)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3890657 Ki 0.89 nM
O=C(Nc1cn(CC(=O)N2CCN(N3CCOCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3938720 Ki 0.89 nM
N#CC1CCN(C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)C1 CHEMBL3920292 Ki 0.89 nM
N#CCCNC1CCC(=CCn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3929567 Ki 0.89 nM
O=C(Nc1cn(CC(=O)N2C[C@@H]3CCN[C@@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3908233 Ki 0.89 nM
COc1cc2c(=O)n(C3CCCCCC3)c3c4cc[nH]c4ncc3c2cc1OC CHEMBL4291720 IC50 0.89 nM
Cc1cc(Nc2nc(N3CCN(C(=O)Cc4ccc(F)cc4)CC3)nn3cccc23)n[nH]1 CHEMBL1682384 IC50 0.9 nM
C[C@H](O)CN1CCC(c2ccc(Nc3ncc4ccc(-c5ccccc5N(C)S(C)(=O)=O)n4n3)cc2)CC1 CHEMBL1923592 IC50 0.9 nM
CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4ccc(N5CCOCC5)cc4)nc23)cc1 CHEMBL2062803 IC50 0.9 nM
O=C1CC[C@H](C(=O)Nc2ccc(-c3ccnc(Nc4ccc(N5CCOCC5)cc4)n3)cc2)N1 CHEMBL2208035 IC50 0.9 nM
COc1cccc(-c2cccc3nc(Nc4ccc(N5CCN(C)CC5)cc4)nn23)c1 CHEMBL2414546 Ki 0.9 nM
O=c1[nH]ccc2c(Nc3c(F)cc(F)cc3Cl)nc3ccncc3c12 CHEMBL3126352 IC50 0.9 nM
CCn1c(C(=O)N(C2CC2)C2CC2)cc2c3c(ncn3C)c(Nc3nc(C)c(C(=O)NC)s3)nc21 CHEMBL3622143 IC50 0.9 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)NCc3ccccc3)cc2)n1 CHEMBL3702904 IC50 0.9 nM
Nc1ccn2ncc(C(=O)Nc3ccnn3-c3cc(Cl)ccc3Cl)c2n1 CHEMBL3670394 Ki 0.9 nM
Nc1nn2cccnc2c1C(=O)Nc1cn(C2CCN(CCCCc3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F CHEMBL3974692 Ki 0.9 nM
O=C(Nc1cn(CC(=O)N2CCN(CCN3CCOCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3965809 Ki 0.9 nM
O=C(Nc1cn(CC(=O)N2CCN(CC3CCOCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3981187 Ki 0.9 nM
CC(=O)Nc1ccc(-c2ccnc(Nc3ccc(NC(=O)CCCCCCC(=O)NO)cc3)n2)cc1 CHEMBL4290831 IC50 0.9 nM
Cc1ccc(C(=O)/C=C/C(=O)N2CCc3ccc(Nc4ncc(C)c(-c5cnn(C(C)C)c5)n4)cc3C2)cc1 CHEMBL4789273 IC50 0.9 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 IC50 0.9 nM
C[C@]12O[C@@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL2367481 IC50 0.9 nM
O=C(Nc1cn(CC(=O)N2CCC(CO)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3968781 Ki 0.91 nM
CCOC(=O)CCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3915926 Ki 0.91 nM
N#CC1(CNC2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3899109 Ki 0.92 nM
O=C(Nc1cn(CC(=O)N2C[C@@H]3CN(C(=O)OCCCO)C[C@@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3959266 Ki 0.93 nM
CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3950688 Ki 0.93 nM
O=C(Nc1cn(CC(=O)N2CC[C@H]3CN(CC4CCOCC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3898231 Ki 0.94 nM
O=C1C=C(CN2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CO1 CHEMBL3972830 Ki 0.94 nM
CS(=O)(=O)c1ccc(-c2cccc3nc(Nc4cccc(CN5CCOCC5)c4)nn23)cc1 CHEMBL3642341 IC50 0.95 nM
C[C@@](O)(c1ccc(Nc2nn([C@H]3CC[C@H](O)C[C@@H]3C#N)cc2C(N)=O)cc1)C(F)(F)F CHEMBL3647859 IC50 0.95 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)NCc3ccncc3)cc2)n1 CHEMBL3702907 IC50 0.95 nM
CC(=O)N1CCC(CN2C[C@@H]3CN(C(=O)Cn4cc(NC(=O)c5cnn6cccnc56)c(-c5cc(Cl)ccc5OC(F)F)n4)C[C@@H]3C2)CC1 CHEMBL3956651 Ki 0.95 nM
O=C(Nc1sc(-c2ccc(CN3CC(F)C3)cc2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3923734 Ki 0.95 nM
CN1C[C@@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5ccc(N)nc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@@H]2C1 CHEMBL3918497 Ki 0.96 nM
CN1CC[C@@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@@H]2C1 CHEMBL4106670 Ki 0.96 nM
CN1CCN(C/C=C/Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3948702 Ki 0.96 nM
O=C(CN1CCOCC1)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3976520 Ki 0.96 nM
O=C(CCCCCCC(=O)Nc1ccc(Nc2nc(-c3cn[nH]c3)c3cc[nH]c3n2)cc1)NO CHEMBL4243347 IC50 0.96 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)ccc1OC(F)F)c1cnc2[nH]ccc2n1 CHEMBL4791878 Ki 0.96 nM
CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4cccc(N5CCNCC5)c4)nc23)cc1 CHEMBL3642402 IC50 0.97 nM
O=C(NO)C1CCN(CCOc2ccc3cc2COC/C=C/COCc2cccc(c2)-c2ccnc(n2)N3)CC1 CHEMBL3961053 IC50 0.97 nM
O=C(Nc1cn(CC(=O)N2CCC(N3CC4CC(C3)O4)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3906087 Ki 0.97 nM
CN(CC1(CC#N)CC1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3916925 Ki 0.98 nM
Cc1cnc(Nc2cnn(C)c2)nc1-c1cnn([C@H](CC#N)C2CCCC2)c1 CHEMBL5395308 IC50 0.98 nM
Cc1cc(Nc2ncc(C)c(N3CC4CCC(C3)N4CCC#N)n2)sn1 CHEMBL5405344 IC50 0.98 nM
Cc1cc(Nc2ncc(C)c(N3CC4CCCC(C3)N4CCC#N)n2)sn1 CHEMBL5404765 IC50 0.98 nM
CCOC(=O)CN1CCC(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3932031 Ki 0.99 nM
N#CCCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3932881 Ki 0.99 nM
O=C(Nc1cn(CC(=O)N2CCN(C3CCOCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3909510 Ki 0.99 nM
CC(C)(C)c1nc2c3ccc(F)cc3c3c(=O)[nH]ccc3c2[nH]1 CHEMBL21156 IC50 1.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 IC50 1.0 nM
O=C1Nc2ccccc2-c2ccnc3[nH]cc(c23)C1c1ccc(O)cc1 CHEMBL584052 Ki 1.0 nM
Oc1ccc(C2Nc3ccccc3-c3ncnc4[nH]cc2c34)c(F)c1 CHEMBL604038 Ki 1.0 nM
Oc1ccc(C2Nc3ccccc3-c3ncnc4[nH]cc2c34)cc1F CHEMBL589869 Ki 1.0 nM
CC(C)[C@@H](Nc1nc2cc[nH]c(=O)c2c2cc(F)ccc12)C(F)(F)F CHEMBL1289097 IC50 1.0 nM
CC(C)[C@@H](Nc1nc2cc[nH]c(=O)c2c2cnccc12)C(F)(F)F CHEMBL1289218 IC50 1.0 nM
Cc1cc(Nc2nc(N3CCN(C(=O)Cc4c(F)cc(Cl)cc4F)CC3)nn3cccc23)n[nH]1 CHEMBL1682388 IC50 1.0 nM
C[C@H](Nc1ncc(C(N)=O)c2[nH]c3cc(-c4cnn(C)c4)ccc3c12)C1CC1 CHEMBL1835137 IC50 1.0 nM
NC(=O)c1cnc(NC(C2CC2)C2CC2)c2c1[nH]c1cc(-c3cnc(N)nc3)ccc12 CHEMBL1833986 IC50 1.0 nM
NC(=O)c1cnc(N[C@H](C2CC2)C(F)(F)F)c2c1[nH]c1cc(-c3cn[nH]c3)ccc12 CHEMBL1835149 IC50 1.0 nM
C[C@H](O)CN1CCN(c2ccc(Nc3ncc4ccc(-c5ccccc5N(C)S(C)(=O)=O)n4n3)cc2F)CC1 CHEMBL1923578 IC50 1.0 nM
CN1CCN(c2ccc(Nc3ncc4ccc(-c5cccc(S(=O)(=O)NC(C)(C)C)c5)n4n3)cc2F)CC1 CHEMBL1923586 IC50 1.0 nM
CNC(=O)c1cnc(N)c2cc(-c3ccc(S(=O)(=O)NC(C)(C)C)cc3)sc12 CHEMBL1938654 IC50 1.0 nM
Cc1nc(-c2cccc(Cl)c2)c(NC(=O)c2cnn3ccc(N)nc23)s1 CHEMBL2178258 Ki 1.0 nM
Cn1cc(NC(=O)c2cnn3ccc(N)nc23)c(-c2cccc(Cl)c2)n1 CHEMBL2178254 Ki 1.0 nM
CCc1nc(N[C@@H]2CCC[C@@H]2C#N)c2cc[nH]c(=O)c2n1 CHEMBL2436945 Ki 1.0 nM
O=c1[nH]ccc2c(Nc3c(Cl)cc(-c4ccn[nH]4)cc3Cl)nc3ccncc3c12 CHEMBL3126348 IC50 1.0 nM
O=c1[nH]ccc2c(Nc3c(Cl)cc(C(F)(F)F)cc3Cl)nc3ccncc3c12 CHEMBL3126344 IC50 1.0 nM
NC(=O)c1cc(-c2ncnc3[nH]ccc23)cn1-c1cc(C(F)(F)F)ccc1Cl CHEMBL3403549 IC50 1.0 nM
CCc1ccc(Cl)cc1-n1cc(-c2ncnc3[nH]ccc23)cc1C(N)=O CHEMBL3403545 IC50 1.0 nM
Cc1ccc(Cl)cc1-n1cc(-c2ncnc3[nH]ccc23)cc1C(N)=O CHEMBL3403541 IC50 1.0 nM
N#C[C@@H]1CCCCC1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)CC(F)(F)F)cc2)n1 CHEMBL3647923 IC50 1.0 nM
CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4ccc(OCCN5CCCC5)cc4)nc23)cc1 CHEMBL3642256 IC50 1.0 nM
CC1(C)CN([C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc([C@@](C)(O)C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3703042 IC50 1.0 nM
CC(C)(c1ccc(Nc2nn([C@@H]3CCCC[C@H]3C#N)cc2C(N)=O)cc1)[C@@H](O)C(F)(F)F CHEMBL3699531 IC50 1.0 nM
COc1ccc(Nc2nc3cccc(-c4ccc(CN5CCS(=O)(=O)CC5)cc4)n3n2)cc1 CHEMBL3642324 IC50 1.0 nM
N#C[C@H]1CC(NCC(=O)O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647736 IC50 1.0 nM
COc1ccc(Nc2nc3c(-c4ccc(S(C)(=O)=O)cc4)cccn3n2)cc1 CHEMBL2062799 IC50 1.0 nM
CCCS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3nc[nH]c3n2)C1 CHEMBL3665162 IC50 1.0 nM
CC(C)NS(=O)(=O)c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3702914 IC50 1.0 nM
COc1cccc(Nc2nc3c(-c4ccc(S(C)(=O)=O)cc4)cccn3n2)c1 CHEMBL2062798 IC50 1.0 nM
N#C[C@H]1C[C@@H](N2CC(O)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647728 IC50 1.0 nM
COc1ccc(Nc2nc3c(C4=CCN(S(C)(=O)=O)CC4)cccn3n2)cc1 CHEMBL3642274 IC50 1.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)NCc3cccnc3)cc2)n1 CHEMBL3702905 IC50 1.0 nM
CC(C)CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ncc3n2)C1 CHEMBL3665158 IC50 1.0 nM
N#C[C@@H]1CCCC[C@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)NCC3CC3)cc2)n1 CHEMBL3702887 IC50 1.0 nM
COCCNS(=O)(=O)c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3702919 IC50 1.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)N3CCOCC3)cc2)n1 CHEMBL3702920 IC50 1.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)NC3CCCCC3)cc2)n1 CHEMBL3702903 IC50 1.0 nM
N#C[C@@H]1CCCC[C@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)NCCN3CCOCC3)cc2)n1 CHEMBL3702889 IC50 1.0 nM
C[C@]1(O)CC[C@H](n2cc(C(N)=O)c(Nc3ccc([C@@](C)(O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647845 IC50 1.0 nM
CCCS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3ccn(C)c3n2)C1 CHEMBL3665160 IC50 1.0 nM
COc1ccc(Cl)cc1-c1c(NC(=O)c2cnn3cccnc23)cnn1CCO CHEMBL3667515 Ki 1.0 nM
CC(=O)N1CCN(S(=O)(=O)c2ccc(Nc3nn([C@H]4CCCC[C@@H]4C#N)cc3C(N)=O)cc2)CC1 CHEMBL3702910 IC50 1.0 nM
C1=N/C2=N/c3ccc(OCCN4CCCC4)c(c3)COC/C=C/COCc3cccc(c3)C(=C1)N2 CHEMBL2035187 IC50 1.0 nM
CC1CN(C(=O)CC#N)C12CCCN(c1ncnc3[nH]ccc13)C2 CHEMBL3689514 IC50 1.0 nM
NC(=O)c1cc(-c2cccc(Cl)c2)cc2c1[nH]c1ccc(C(=O)N3CCOCC3)cc12 CHEMBL3622195 IC50 1.0 nM
CN1CCN(C(=O)c2ccc3[nH]c4c(C(N)=O)cc(-c5ccc(Cl)cc5)cc4c3c2)CC1 CHEMBL3589169 IC50 1.0 nM
NC(=O)c1cc(-c2cccc(Cl)c2)cc2c1[nH]c1ccc(C(=O)N3CCOC(CO)C3)cc12 CHEMBL3646838 IC50 1.0 nM
COc1ccc(-c2cc(C(N)=O)c3[nH]c4ccc(C(=O)N5CCN(C(=O)C6CC6)CC5)cc4c3c2)cc1F CHEMBL3646840 IC50 1.0 nM
COc1ccc(-c2cc(C(N)=O)c3[nH]c4ccc(C(=O)N5C[C@@H]6C[C@H]5CO6)cc4c3c2)cc1F CHEMBL3646841 IC50 1.0 nM
COc1ccc(-c2cc(C(N)=O)c3[nH]c4ccc(C(=O)N5CCC(O)CC5)cc4c3c2)cc1F CHEMBL3646842 IC50 1.0 nM
CC(C)(C)N1CCN(Cc2ccc3c(c2)[nH]c2c(C(N)=O)cc(-c4cccc(Cl)c4)nc23)CC1 CHEMBL3649606 IC50 1.0 nM
NC(=O)c1cc(-c2cccc(Cl)c2)nc2c1[nH]c1ccc(CN3CCOCC3)cc12 CHEMBL3649607 IC50 1.0 nM
CN1CCN(c2ccc3c(c2)[nH]c2c(C(N)=O)cc(-c4cccc(Cl)c4)nc23)CC1 CHEMBL3649609 IC50 1.0 nM
COc1ccc(-c2cc(C(N)=O)c3[nH]c4cc(N5CCN(C)CC5)ccc4c3n2)cc1F CHEMBL3639484 IC50 1.0 nM
CN1CCC(Nc2ccc3c(c2)[nH]c2c(C(N)=O)cc(-c4cccc(C(F)(F)F)c4)nc23)CC1 CHEMBL3649611 IC50 1.0 nM
NC(=O)c1cc(-c2ccc(CN3CCOCC3)cc2)nc2c1[nH]c1cc(N)ccc12 CHEMBL3649612 IC50 1.0 nM
NC(=O)c1cc(-c2ccc(CN3CCOCC3)cc2)nc2c1[nH]c1cc(N3CCS(=O)(=O)CC3)ccc12 CHEMBL3649613 IC50 1.0 nM
NC(=O)c1cc(-c2ccc(CN3CCOCC3)s2)nc2c1[nH]c1cc(N3CCOCC3=O)ccc12 CHEMBL3649614 IC50 1.0 nM
COc1ccc(-c2cc(C(N)=O)c3[nH]c4cc(N5CCOCC5)ccc4c3n2)cc1F CHEMBL3649615 IC50 1.0 nM
NC(=O)c1cc(-c2ccc(CN3CCOCC3)s2)nc2c1[nH]c1cc(N3CCOCC3)ccc12 CHEMBL3649616 IC50 1.0 nM
NC(=O)c1cc(-c2ccc(OCCN3CCOCC3)c(Cl)c2)nc2c1[nH]c1cc(N3CCOCC3)ccc12 CHEMBL3649617 IC50 1.0 nM
Cc1ccc(-c2cc(C(N)=O)c3[nH]c4ccc(C(=O)O)cc4c3c2)c(F)c1 CHEMBL3649628 IC50 1.0 nM
NC(=O)c1cc(-c2ncccn2)cc2c1[nH]c1cc(C(=O)N3CCOCC3)ccc12 CHEMBL3649629 IC50 1.0 nM
Cn1ccc2cc(-c3cc(C(N)=O)c4[nH]c5cc(C(=O)N6CCOCC6)ccc5c4n3)ccc21 CHEMBL3649630 IC50 1.0 nM
NC(=O)c1cc(-c2ccc3sccc3c2)nc2c1[nH]c1cc(C(=O)N3CCOCC3)ccc12 CHEMBL3649631 IC50 1.0 nM
NC(=O)c1cc(-c2ccc3scnc3c2)nc2c1[nH]c1cc(C(=O)N3CCOCC3)ccc12 CHEMBL3649633 IC50 1.0 nM
NC(=O)c1cc(-c2ccc(C3CC3)nc2)nc2c1[nH]c1cc(N3CCOCC3)ccc12 CHEMBL3649643 IC50 1.0 nM
CN(C)c1ccc(-c2cc(C(N)=O)c3[nH]c4cc(N5CCOCC5)ccc4c3n2)cn1 CHEMBL3649646 IC50 1.0 nM
NC(=O)c1cc(-c2ccc(N3CCOCC3)nc2)nc2c1[nH]c1cc(N3CCOCC3)ccc12 CHEMBL3649647 IC50 1.0 nM
COC(=O)N1CCN(C(=O)c2ccc3c(c2)[nH]c2c(C(N)=O)cc(-c4ccc(OC)c(F)c4)cc23)CC1 CHEMBL3649648 IC50 1.0 nM
COc1ccc(-c2cc(C(N)=O)c3[nH]c4cc(C(=O)N5CCCC(C)(O)C5)ccc4c3c2)cc1F CHEMBL3649649 IC50 1.0 nM
ClC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3954894 IC50 1.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(=O)N4CCS(=O)(=O)CC4)cc3)n2)CC1 CHEMBL3935508 IC50 1.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(C)(=O)=O)cc3)n2)CC1 CHEMBL3914600 IC50 1.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(N)(=O)=O)cc3)n2)CC1 CHEMBL3949472 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2cccc(O)c2)CC1 CHEMBL3933102 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(S(=O)(=O)c2ccccc2)CC1 CHEMBL3910522 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(Nc2ccccc2F)CC1 CHEMBL3950253 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CCC(Nc2ccccc2)CC1 CHEMBL3892599 IC50 1.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CCC(N2CC(F)C2)CC1 CHEMBL3919665 IC50 1.0 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(OC(F)(F)F)cc2)n1 CHEMBL4108565 IC50 1.0 nM
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCC(C(=O)NO)CC4)cc3)n2)cc1 CHEMBL4172110 IC50 1.0 nM
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCC(C(=O)NCCCC(=O)NO)CC4)cc3)n2)cc1 CHEMBL4175964 IC50 1.0 nM
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCC(C(=O)NCCCCC(=O)NO)CC4)cc3)n2)cc1 CHEMBL4168763 IC50 1.0 nM
Cc1cnc(Nc2ccc(N3CCC(N(C)CCCO)CC3)c(F)c2)nc1-c1cnn(C(C)C)c1 CHEMBL4560698 IC50 1.0 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@H]2CCCN(C)C2)c2nc(N)ncc2c1 CHEMBL5086526 pIC50 1.0 nM
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=O)c1c(F)cccc1F CHEMBL191003 IC50 1.0 nM
CN(CC1Oc2ccccc2O1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3934132 Ki 1.01 nM
CC1(C(=O)OCCN2CCOCC2)CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3958970 Ki 1.01 nM
O=C(Nc1cn(CC(=O)N2CCC(CN3CCOCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3942091 Ki 1.02 nM
CN1[C@@H]2CC[C@H]1CN(C(=O)Cn1cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n1)C2 CHEMBL3950200 Ki 1.03 nM
CN(C)C(=O)CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3961154 Ki 1.03 nM
CC1CN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CCN1C CHEMBL3933501 Ki 1.03 nM
CC(c1ccccc1)N1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3974475 Ki 1.04 nM
C[C@H]1CNC(=O)c2cnn3ccc(nc23)N[C@H](C)c2cc(F)ccc2O1 CHEMBL4298138 IC50 1.04 nM
O=C(Nc1sc(N2CCC(N3CC(F)(F)C3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3983975 Ki 1.05 nM
O=C(Nc1cn(CC(=O)N2CCC(C(=O)OCCN3CCOCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3922554 Ki 1.05 nM
CC(C)(C)OC(=O)N1CC[C@@H](n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)[C@H](O)C1 CHEMBL4109552 Ki 1.05 nM
CN(C)C(=O)CN1CCC(c2ccc(Nc3nc4c(-c5cnn(-c6ccc(F)cc6)c5)cccn4n3)cc2)CC1 CHEMBL3645015 IC50 1.06 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CCCOC(=O)N4CCOCC4)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3944568 Ki 1.06 nM
CC(C)(C)OC(=O)N1CC[C@H](O)[C@@H](n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3905318 Ki 1.06 nM
CC(C#N)CNC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3940217 Ki 1.06 nM
CCCCN(C)C1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3919476 Ki 1.07 nM
CN(CC1(C)COC1)C1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3920538 Ki 1.07 nM
COc1cc2c(=O)n(C3CCCCC3)c3c4cc[nH]c4ncc3c2cc1OC CHEMBL4295151 IC50 1.07 nM
O=C(Nc1sc(N2CCN(CC(F)(F)F)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3950547 Ki 1.08 nM
CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C[C@H]1CO CHEMBL3952702 Ki 1.08 nM
Cc1cc(Nc2nc(N3CCN(C(=O)c4ccccc4S(C)(=O)=O)CC3)nn3cccc23)n[nH]1 CHEMBL1682380 IC50 1.1 nM
Cc1ccc(CC(=O)N2CCN(c3nc(Nc4cc(C)[nH]n4)c4cccn4n3)CC2)cc1 CHEMBL1682382 IC50 1.1 nM
CN1CCN(c2ccc(Nc3ncc4ccc(-c5ccccc5N(C)S(C)(=O)=O)n4n3)cc2Cl)CC1 CHEMBL1923582 IC50 1.1 nM
CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4cccc(N5CCC(N6CCOCC6)CC5)c4)nc23)cc1 CHEMBL2062808 IC50 1.1 nM
Cn1nc(-c2cnc3[nH]cc(C(=O)N[C@@H](C(=O)N4CC(C#N)C4)C4CC4)c3n2)c2ccc(Cl)cc21 CHEMBL2376154 IC50 1.1 nM
CC(C)c1cc(-c2cccn3nc(Nc4ccc(C(=O)O)cc4)nc23)ccn1 CHEMBL2414539 Ki 1.1 nM
Cc1cc(Nc2nc3cccc(-c4cccc(C(C)C)c4)n3n2)ccn1 CHEMBL2414548 Ki 1.1 nM
CN1CCC(c2ccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)cc2)CC1 CHEMBL3642287 IC50 1.1 nM
CS(=O)(=O)c1ccc(-c2cccc3nc(Nc4ccc(CN5CCOCC5)cc4)nn23)cc1 CHEMBL3642314 IC50 1.1 nM
CN1CCN(c2ccc(Nc3nc4cccc(-c5ccc(CN6CCS(=O)(=O)CC6)cc5)n4n3)cc2)CC1 CHEMBL3642302 IC50 1.1 nM
CN(CC(F)(F)c1ccccc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3945615 Ki 1.1 nM
C[C@@H]1COCCN1C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL4107458 Ki 1.1 nM
O=C(Nc1cn(CC(=O)N2CCN(CCN3CCSCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3973184 Ki 1.1 nM
Cc1nccc(Nc2cc(N[C@@H]3CCN(c4ccc(C#N)cn4)C[C@@H]3F)c(C(N)=O)cn2)n1 CHEMBL4466236 IC50 1.1 nM
Cc1nc(-c2cc(Cl)ccc2OC(F)F)c(NC(=O)c2cnn3cccnc23)[nH]1 CHEMBL4764700 Ki 1.1 nM
Cc1cnc(Nc2ccc3c(c2)CNC3=O)nc1-c1cnn(CCC#N)c1 CHEMBL4845662 IC50 1.1 nM
Cc1cnc(Nc2ccc(N3CCN(C)CC3)c(F)c2)nc1Nc1ccc(S(=O)(=O)NC(C)(C)C)cc1 CHEMBL5289028 IC50 1.1 nM
O=C(Nc1cn(CC(=O)N2CCC3(CCN(CC4CCN(C(=O)OCc5ccccc5)CC4)C3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3891254 Ki 1.11 nM
O=C(Nc1cn(CC(=O)N2CCOCC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3901982 Ki 1.11 nM
CN(C)C1CCN(C(=O)c2ccc(-n3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)cc2)CC1 CHEMBL3900032 Ki 1.11 nM
CC1(CN2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)COC1 CHEMBL3960123 Ki 1.11 nM
N#CCCCNC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3899912 Ki 1.11 nM
C[C@@H](O)CN1CCN(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)CC1 CHEMBL3642366 IC50 1.13 nM
O=C(Nc1cn(CC(=O)N2C[C@H]3CN(CCCO)C[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3950713 Ki 1.13 nM
CC1(CN(CCC(F)(F)F)C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)COC1 CHEMBL3923871 Ki 1.13 nM
C[C@H](O)CN1CCN(c2ccc(Nc3ncc4ccc(-c5ccccc5N(C)S(C)(=O)=O)n4n3)cc2)CC1 CHEMBL1923569 IC50 1.14 nM
O=C(Nc1cn(CC(=O)N2CCC(NCCc3ccc(O)cc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3952689 Ki 1.15 nM
O=C(Nc1cn(CC(=O)N2CCC(N3Cc4ccc(Cl)cc4C3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3941221 Ki 1.15 nM
O=C(Nc1cn(CC(=O)N2CC[C@H]3CNC[C@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3892055 Ki 1.16 nM
CC(C)CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3900031 Ki 1.16 nM
CN(C)CCOC(=O)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3969204 Ki 1.16 nM
CN(CC1OCCO1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3923151 Ki 1.16 nM
CC(C)N1C[C@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@H]2C1 CHEMBL3895921 Ki 1.17 nM
O=C(Nc1cn(CC(=O)N2CCN(CCOCCO)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3967093 Ki 1.18 nM
CCN[C@@H](C)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3949681 Ki 1.19 nM
COc1ccc(CC(=O)N2CCN(c3nc(Nc4cc(C)[nH]n4)c4cccn4n3)CC2)cc1 CHEMBL1682385 IC50 1.2 nM
CN1CCN(c2ccc(Nc3ncc4ccc(-c5cccc(S(=O)(=O)NC(C)(C)C)c5)n4n3)cc2Cl)CC1 CHEMBL1923587 IC50 1.2 nM
N#CCC(=O)N1CCC[C@@H](n2cnc3cnc4[nH]ccc4c32)C1 CHEMBL2152300 Ki 1.2 nM
CCn1c(C(=O)N(C2CC2)C2CC2)cc2c3c(ncn3C)c(Nc3cc(C)[nH]n3)nc21 CHEMBL3622150 IC50 1.2 nM
CS(=O)(=O)NC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3984562 IC50 1.2 nM
CN(C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1)[C@@H]1CCOC1 CHEMBL4112987 Ki 1.2 nM
O=c1[nH]c2cnc(-c3cnc4ccc(F)cn34)nc2n1[C@@H]1CCOc2c(F)cccc21 CHEMBL4448906 IC50 1.2 nM
O=c1[nH]c2cnc(-n3cnc4ccc(F)cc43)nc2n1[C@@H]1CCOc2c(F)cccc21 CHEMBL1079593 IC50 1.2 nM
COc1c(F)cc(Cl)cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12 CHEMBL4796325 Ki 1.2 nM
O=C(Nc1cn(CC(=O)N2CC[C@@H]3CNCC[C@@H]32)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL4112868 Ki 1.21 nM
O=C(O)CN(CCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1)Cc1cccnc1 CHEMBL3980934 Ki 1.21 nM
CN1CC[C@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@H]2C1 CHEMBL3891137 Ki 1.22 nM
CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C[C@@H]1CO CHEMBL4113953 Ki 1.22 nM
CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3cc[nH]c3n2)C1 CHEMBL3665165 IC50 1.23 nM
CC(C)N1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3940918 Ki 1.24 nM
O=C(Nc1cn(CC(=O)N2CCN3CCCCC3C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3913483 Ki 1.25 nM
CN[C@@H](C)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3954236 Ki 1.25 nM
CC1(N2CCOCC2)CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3981362 Ki 1.25 nM
CNC(=O)[C@@H]1CCCN1C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3900605 Ki 1.25 nM
CN(C)C(=O)CN1CCN(CC2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3928573 Ki 1.25 nM
O=C(Nc1cn(CC(=O)N2CCC(N3C[C@@H]4C[C@H]3CO4)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3892587 Ki 1.25 nM
CN1CCC2C(C1)OCCN2C(=O)Cn1cc(NC(=O)c2c(N)nn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3898224 Ki 1.26 nM
CC(C)S(=O)(=O)c1ccc(-c2cccn3nc(Nc4cccc(N5CCN(C)CC5)c4)nc23)cc1 CHEMBL2062810 IC50 1.27 nM
O=C(NO)c1ccc(OCCOc2ccc3cc2COC/C=C/COCc2cccc(c2)-c2ccnc(n2)N3)cc1 CHEMBL3924682 IC50 1.27 nM
O=C(Nc1cn(CC(=O)N2CCC(NC(c3ccccc3)C(F)(F)F)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3956283 Ki 1.27 nM
O=C(Nc1cn(CC(=O)N2CCC3(CNC3)C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3930303 Ki 1.28 nM
CN1CC2(C1)CN(C(=O)Cn1cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n1)C2 CHEMBL3969424 Ki 1.29 nM
CC(C)CN1CCC2(CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)C1 CHEMBL3909300 Ki 1.29 nM
CSCCOC(=O)CNCCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3945907 Ki 1.29 nM
CS(=O)(=O)c1ccc(Nc2nc3c(-c4ccc(S(C)(=O)=O)cc4)cccn3n2)cc1 CHEMBL2062801 IC50 1.3 nM
Nc1ccn2ncc(C(=O)Nc3c[nH]nc3-c3cccc(Cl)c3)c2n1 CHEMBL2178255 Ki 1.3 nM
Cn1nc(-c2cnc3[nH]cc(C(=O)N[C@@H](C(=O)N4CC(C#N)C4)C(C)(C)C)c3n2)c2ccc(Cl)cc21 CHEMBL2376155 IC50 1.3 nM
CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3nc4cccc(-c5ccc(S(C)(=O)=O)cc5)n4n3)cc2)CC1 CHEMBL3642306 IC50 1.3 nM
CN1CCN(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)CC1 CHEMBL2062804 IC50 1.3 nM
CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4ccc(OCCN5CCOCC5)cc4)nc23)cc1 CHEMBL3642268 IC50 1.3 nM
CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C(C)(C)C1 CHEMBL3933811 Ki 1.3 nM
N#CC1CN(C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)C1 CHEMBL3920585 Ki 1.3 nM
O=C(Nc1cn(CC(=O)N2CCC(OCC(=O)N3CCOCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3981642 Ki 1.3 nM
O=c1[nH]cc(Cl)cc1Nc1ncc2[nH]c(=O)n([C@@H]3CCOc4c(F)cccc43)c2n1 CHEMBL4482927 IC50 1.3 nM
CN(CCc1ccc(O)cc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3981440 Ki 1.31 nM
CN(CC1(C#N)CCCCC1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3921728 Ki 1.34 nM
CC(C)(C)OC(=O)N1CC[C@@H](c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)[C@@H](O)C1 CHEMBL3642407 IC50 1.35 nM
O=C(Nc1cn(CC(=O)N2CC3(CCNCC3)C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3942739 Ki 1.37 nM
C[C@@H](Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1)N(C)C CHEMBL3925409 Ki 1.37 nM
O=C(Nc1cn(CCN2CCNCC2=O)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3899509 Ki 1.37 nM
CN(C)C[C@H]1CCCN1C(=O)Cn1cc(NC(=O)c2c(N)nn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL4108609 Ki 1.38 nM
CN1CCC2(C1)CN(C(=O)Cn1cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n1)C2 CHEMBL3975592 Ki 1.38 nM
Nc1nn2cccnc2c1-c1cc(NCc2ccc(Cl)cc2)ncn1 CHEMBL569012 IC50 1.4 nM
C[C@@H](Nc1cc(-c2c(N)nn3cccnc23)ncn1)c1ccccc1 CHEMBL568816 IC50 1.4 nM
CN1CCN(C2CCN(c3cccc(Nc4nc5c(-c6ccc(S(C)(=O)=O)cc6)cccn5n4)c3)CC2)CC1 CHEMBL2062529 IC50 1.4 nM
COc1ccc(-c2cccn3nc(Nc4cnn([C@H](C)CO)c4)nc23)cc1 CHEMBL2414536 Ki 1.4 nM
CCn1c(C(=O)N(C2CC2)C2CC2)cc2c3c(ncn3C)c(Nc3nccs3)nc21 CHEMBL3622134 IC50 1.4 nM
CCn1c(C(=O)N(C2CC2)C2CC2)cc2c3c(ncn3C)c(Nc3nc(C)c(S(C)(=O)=O)s3)nc21 CHEMBL3622145 IC50 1.4 nM
CCc1nc(Nc2nc3c(cc(C(=O)N(C4CC4)C4CC4)n3CC)c3c2ncn3C)sc1C CHEMBL3622142 IC50 1.4 nM
CS(=O)(=O)c1ccc(Nc2nc3cccc(-c4ccc(S(C)(=O)=O)cc4)n3n2)cc1 CHEMBL3642322 IC50 1.4 nM
O=C(CCCCCCOc1ccc2cc1COC/C=C/COCc1cccc(c1)-c1ccnc(n1)N2)NO CHEMBL3917405 IC50 1.4 nM
CN(CC1(C)COC1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3944446 Ki 1.4 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1n1ccc2cnc3[nH]cc(C#N)c3c21 CHEMBL5273533 IC50 1.4 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cc3F)c(F)c(N3CCOCC3)n2)n[nH]1 CHEMBL2381983 Ki 1.41 nM
CN(CC1(C#N)CCCCC1)C1CCN(C(=O)C2CCN(c3nc(-c4cc(Cl)ccc4OC(F)F)c(NC(=O)c4cnn5cccnc45)s3)CC2)CC1 CHEMBL3974690 Ki 1.41 nM
CN(CCCC#N)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3959085 Ki 1.41 nM
CN1CCN(CC2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3943256 Ki 1.42 nM
CN1CCN(Cc2cccc(Nc3nc4cccc(-c5ccc(S(C)(=O)=O)cc5)n4n3)c2)CC1 CHEMBL3642342 IC50 1.43 nM
CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4cccc([C@@H]5CCNC[C@@H]5O)c4)nc23)cc1 CHEMBL3642409 IC50 1.43 nM
CCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3955984 Ki 1.43 nM
O=C(Nc1sc(N2CCC(N3CC(F)C3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3898459 Ki 1.44 nM
O=C(Nc1cn(CC(=O)N2CCC(NCCc3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3951483 Ki 1.45 nM
CN1CCN(C(=O)C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3937016 Ki 1.45 nM
CN(CCCC(N)=O)C1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3935428 Ki 1.46 nM
CS(=O)(=O)CCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3928370 Ki 1.46 nM
CN1CC[C@@H]2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC[C@@H]21 CHEMBL4109979 Ki 1.47 nM
O=C(Nc1cn(CC(=O)N2CCC(NC3CCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3977209 Ki 1.47 nM
CN1CCC2(CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)C1 CHEMBL3933698 Ki 1.47 nM
COC(=O)CCN(C)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3970778 Ki 1.47 nM
O=C(Nc1cn(CC(=O)N2CCC(N3CCCOCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3905858 Ki 1.48 nM
Nc1nn2cccnc2c1-c1cc(NCc2ccc(F)cc2)ncn1 CHEMBL570686 IC50 1.5 nM
C[C@H](O)CN1CCC(c2ccc(Nc3ncc4ccc(-c5cccc(S(=O)(=O)NC(C)(C)C)c5)n4n3)cc2)CC1 CHEMBL1921819 IC50 1.5 nM
CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4ccccc4)nc23)cc1 CHEMBL2062796 IC50 1.5 nM
CCn1nc(Nc2nc3c(cc(C(=O)N(C4CC4)C4CC4)n3CC)c3c2ncn3C)cc1C CHEMBL3622148 IC50 1.5 nM
COc1ncc(C#N)cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12 CHEMBL3667518 Ki 1.5 nM
N#Cc1cc(F)c(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)c(F)c1 CHEMBL3972475 IC50 1.5 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL4089234 IC50 1.5 nM
N#CC[C@H]1CC[C@H](n2c(=O)[nH]c3cnc(Nc4ccc[nH]c4=O)nc32)CC1 CHEMBL4463007 IC50 1.5 nM
Cc1cc(Nc2ncc(C)c(N3CCN(CC#N)[C@@H](C)C3)n2)sn1 CHEMBL5415481 IC50 1.5 nM
CC1CN(C)CCN1C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3927656 Ki 1.54 nM
CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4ccc5c(c4)CCC(N4CCOCC4)CC5)nc23)cc1 CHEMBL3642368 IC50 1.55 nM
C[C@H]1COCCN1C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3956219 Ki 1.56 nM
c1cc2c(NC3CCCCCC3)c(-c3cn[nH]c3)cnc2[nH]1 CHEMBL5430869 IC50 1.575 nM
CCCS(=O)(=O)Nc1ccc(-c2ccc3[nH]nc(N)c3c2)cc1 CHEMBL1992342 pKi 1.585 nM
CCc1cc(O)c(F)cc1-c1cc(NC[C@H](C)O)c2nc(N)ncc2c1 CHEMBL5078141 pIC50 1.585 nM
CNC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3966860 Ki 1.59 nM
CN1CCC2(CC1)CCN(C(=O)Cn1cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n1)C2 CHEMBL3943816 Ki 1.59 nM
Oc1ccc(C2Nc3ccccc3-c3ccnc4[nH]cc2c34)cc1 CHEMBL600875 Ki 1.6 nM
CN1CCN(c2ccc(Nc3ncc4ccc(-c5ccccc5N(C)S(C)(=O)=O)n4n3)cc2)CC1 CHEMBL1821735 IC50 1.6 nM
Cc1ccccc1-c1nn(C)cc1NC(=O)c1cnn2ccc(N)nc12 CHEMBL2178802 Ki 1.6 nM
COc1ccc(-c2cccc3nc(Nc4ccc(C(=O)O)cc4)nn23)cc1 CHEMBL2414554 Ki 1.6 nM
O=C(NC1CCOCC1)c1cnn2ccc(NC3Cc4ccccc4C3)nc12 CHEMBL3670395 Ki 1.6 nM
CN(CCc1ccccn1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3897795 Ki 1.6 nM
CCOC(=O)CNC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3970958 Ki 1.6 nM
CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1(C)C CHEMBL3942659 Ki 1.6 nM
COc1cc(Nc2ncc(C)c(-c3cc4c(o3)CCN(C(=O)CC#N)C4)n2)cc(OC)c1OC CHEMBL4440795 IC50 1.6 nM
Cc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1-c1cc2c(o1)CCN(C(=O)CC#N)C2 CHEMBL4524343 IC50 1.6 nM
CC[C@@H]1CN(C(=O)NCC(F)(F)F)C[C@@H]1c1cnc2cnc3[nH]ccc3n12 CHEMBL3622821 IC50 1.6 nM
CN1C[C@H]2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C[C@H]2C1 CHEMBL4111284 Ki 1.61 nM
CN(CCC#N)C1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3958770 Ki 1.61 nM
O=C(Nc1cn(CC(=O)N2CCNCC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3980200 Ki 1.61 nM
CCN1CCP(=O)(c2ccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)cc2)CC1 CHEMBL3645118 IC50 1.62 nM
CN1CCN(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)C(=O)C1 CHEMBL3642424 IC50 1.63 nM
CN(CCCc1ccccc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3898708 Ki 1.63 nM
CNC(=O)[C@@H]1CCCN1CC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3962975 Ki 1.64 nM
CN1CCN(C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3968155 Ki 1.65 nM
CN(CCc1ccccc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3906556 Ki 1.66 nM
COCCN(C)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3901746 Ki 1.68 nM
CN1CC2(CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C2)C1 CHEMBL3921334 Ki 1.68 nM
O=C(Nc1cn(CC(=O)N2CCCN(CCO)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3941450 Ki 1.68 nM
CN1CCC2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2C1 CHEMBL3912732 Ki 1.69 nM
C[C@@H](N)C(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL2208032 IC50 1.7 nM
COc1ccc(-c2cccn3nc(Nc4ccc(C(=O)O)cc4)nc23)cc1 CHEMBL2414533 Ki 1.7 nM
CN1CCN(c2ccc(Nc3nc4c(-c5ccc(S(=O)(=O)N(C)C)cc5)cccn4n3)cc2)CC1 CHEMBL3642290 IC50 1.7 nM
CN1CCN(Cc2ccc(Nc3nc4cccc(-c5ccc(S(C)(=O)=O)cc5)n4n3)cc2)CC1 CHEMBL3642315 IC50 1.7 nM
N#CCC(=O)N1CC(F)(F)C12CCN(c1ncnc3[nH]ccc13)C2 CHEMBL3689516 IC50 1.7 nM
[N-]=[N+]=NC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL4111044 IC50 1.7 nM
O=C(Nc1cn([C@@H]2CNCC[C@H]2O)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL4115622 Ki 1.7 nM
NC(=O)c1cnc2[nH]ccc2c1NC1C2CC3CC1CC(O)(C3)C2 CHEMBL4238926 IC50 1.7 nM
N#CCC(=O)N1CCC[C@H](n2c(=O)[nH]c3cnc(Nc4ccc[nH]c4=O)nc32)C1 CHEMBL4550310 IC50 1.7 nM
O=C(NO)c1ccc(NCCOc2ccc3cc2COC/C=C/COCc2cccc(c2)-c2ccnc(n2)N3)cc1 CHEMBL3915689 IC50 1.71 nM
CN(C)CCOC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3979961 Ki 1.71 nM
CN1CCN(c2cccc(Nc3nc4c(-c5ccc(P(C)(C)=O)cc5)cccn4n3)c2)CC1 CHEMBL2062813 IC50 1.73 nM
CN1C[C@@H]2CN(Cc3nc(-c4cc(Cl)ccc4OC(F)F)c(NC(=O)c4cnn5cccnc45)s3)C[C@@H]2C1 CHEMBL3914707 Ki 1.73 nM
CN(C)C(=O)CN(C)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3931538 Ki 1.73 nM
CN1CCC2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CCC21 CHEMBL3981242 Ki 1.76 nM
CN(CCC1CCCCC1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3965438 Ki 1.77 nM
NC1CCC(=CCn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3922122 Ki 1.77 nM
CN1CC[C@@H]2[C@@H](CCN2C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3896393 Ki 1.78 nM
NC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3910787 Ki 1.78 nM
CN(C)CCOC(=O)C1(C)CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3978448 Ki 1.79 nM
C[C@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL457871 Kd 1.8 nM
COc1cc(F)c(CC(=O)N2CCN(c3nc(Nc4cc(C)n[nH]4)c4cccn4n3)CC2)c(F)c1 CHEMBL1615027 IC50 1.8 nM
Nc1ccn2ncc(C(=O)Nc3conc3-c3cccc(Cl)c3)c2n1 CHEMBL2178257 Ki 1.8 nM
CNc1nc(N[C@@H]2CCC[C@@H]2C#N)c2cc[nH]c(=O)c2n1 CHEMBL2436939 Ki 1.8 nM
CN1CCN(C2CCN(c3ccc(Nc4nc5c(-c6ccc(S(C)(=O)=O)cc6)cccn5n4)cc3)CC2)CC1 CHEMBL3642288 IC50 1.8 nM
Cc1nc(-c2ccccc2C)c(NC(=O)c2cnn3ccc(N)nc23)s1 CHEMBL3670391 Ki 1.8 nM
CN(Cc1ccc(Cl)cc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3905167 Ki 1.8 nM
CN1CN([C@H]2CC[C@H](CNS(=O)(=O)CC(F)(F)F)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3947242 IC50 1.8 nM
Cc1cnc(Nc2ccc(N3CCOCC3)cc2)nc1-c1ccc(NC(=O)CCCCCCC(=O)NO)cc1 CHEMBL4281785 IC50 1.8 nM
CC(=O)c1ccc(NC(=O)N2CCN(c3nc(Nc4ccc(N5CCOCC5)cc4)ncc3Cl)CC2)cc1 CHEMBL5412815 IC50 1.8 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1ccc(C(=O)NO)cc1 CHEMBL5408198 IC50 1.8 nM
CN(Cc1ccccc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3959615 Ki 1.81 nM
CCOC(=O)C1CCN(CCN2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3918255 Ki 1.81 nM
CN(CC(F)(F)F)C1CCN(C(=O)C2CCN(c3nc(-c4cc(Cl)ccc4OC(F)F)c(NC(=O)c4cnn5cccnc45)s3)CC2)CC1 CHEMBL3934458 Ki 1.82 nM
CN1CCC2(CC1)CN(C(=O)Cn1cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n1)C2 CHEMBL3968827 Ki 1.82 nM
COc1cc2c(=O)n(C3CCCCCCC3)c3c4cc[nH]c4ncc3c2cc1OC CHEMBL4281080 IC50 1.82 nM
CN1CC[C@H]2[C@H](CCN2C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL4107631 Ki 1.85 nM
CN(C)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3925466 Ki 1.87 nM
CCN1CCN(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)C(=O)C1 CHEMBL3642425 IC50 1.88 nM
CCn1cc(Nc2nc3c(-c4ccc(S(C)(=O)=O)cc4)cccn3n2)cn1 CHEMBL3644957 IC50 1.88 nM
CCn1c(C(=O)N(C2CC2)C2CC2)cc2c3c(ncn3C)c(Nc3nc(C)cs3)nc21 CHEMBL3622135 IC50 1.9 nM
CC(C)(C)OC(=O)N1CCC(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)CC1 CHEMBL3642401 IC50 1.9 nM
COc1ccc(Nc2nc3cccc(-c4ccc(S(C)(=O)=O)cc4)n3n2)cc1 CHEMBL3642320 IC50 1.9 nM
Clc1cnc2nc1NCc1cccc(c1)OCCCc1cccc(c1)N2 CHEMBL3694581 IC50 1.9 nM
N#CCC(=O)N1CC(F)(F)C12CCCN(c1ncnc3[nH]ccc13)C2 CHEMBL3689517 IC50 1.9 nM
N#CCCN(CCC#N)C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3951107 IC50 1.9 nM
CN(CC1CCC(=O)O1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3962087 Ki 1.9 nM
CN1CN([C@H]2CC[C@H](COCCC#N)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3896113 IC50 1.9 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C3CC3)cc2)n1 CHEMBL4077886 IC50 1.9 nM
Cc1c[nH]c(=O)c(Nc2ncc3[nH]c(=O)n([C@@H]4CCOc5c(F)cccc54)c3n2)c1 CHEMBL4536419 IC50 1.9 nM
CN(C)C(=O)CCCN(C)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3977319 Ki 1.91 nM
CN(CC1(C)OCCO1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3907006 Ki 1.92 nM
CN1CCC2(CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)C2)C1 CHEMBL3958363 Ki 1.93 nM
Cn1ccc2ncc(-c3cccnc3N[C@H]3CCCN(S(C)(=O)=O)C3)nc21 CHEMBL3665154 IC50 1.96 nM
COC(=O)C1CCN(CCN2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3985677 Ki 1.96 nM
CN(CCc1ccc(C(F)(F)F)cc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3970542 Ki 1.97 nM
c1ccc(CNc2nc(Nc3cc(C4CC4)[nH]n3)c3sccc3n2)cc1 CHEMBL1997924 pKi 1.995 nM
CCc1cc(O)c(F)cc1-c1cc(NC(CO)CO)c2nc(N)ncc2c1 CHEMBL5085176 pIC50 1.995 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@@H]2C[C@H]3CC[C@@H](C2)N3)c2nc(N)ncc2c1 CHEMBL5075673 pIC50 1.995 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@@H](C)CO)c2nc(NCCOCCN(C)C)ncc2c1 CHEMBL5094089 pIC50 1.995 nM
Oc1ccc(C2Nc3ccccc3-c3ccnc4[nH]cc2c34)cc1Br CHEMBL592033 Ki 2.0 nM
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(CN4CCS(=O)(=O)CC4)cc3)n2)cc1 CHEMBL1078889 IC50 2.0 nM
Cc1cc(Nc2nc(N3CCN(C(=O)CCc4ccccc4)CC3)nn3cccc23)n[nH]1 CHEMBL1682372 IC50 2.0 nM
Cn1cc(-c2ccc3c(c2)[nH]c2c(C(N)=O)cnc(NC(C4CC4)C4CC4)c23)cn1 CHEMBL1835141 IC50 2.0 nM
NC(=O)c1cnc(N[C@H](C2CC2)C(F)(F)F)c2c1[nH]c1cc(-c3ccc(N)nc3)ccc12 CHEMBL1835150 IC50 2.0 nM
NC(=O)c1cnc(N[C@H](C2CC2)C(F)(F)F)c2c1[nH]c1cc(-c3ccc(N4CCS(=O)(=O)CC4)nn3)ccc12 CHEMBL1835152 IC50 2.0 nM
NC(=O)c1cnc(NC(C2CC2)C2CC2)c2c1[nH]c1cc(-c3cccnn3)ccc12 CHEMBL1835147 IC50 2.0 nM
CCC(Nc1ncc(C(N)=O)c2[nH]c3cc(-c4cnn(C)c4)ccc3c12)C1CC1 CHEMBL1835139 IC50 2.0 nM
CN(c1ccccc1-c1ccc2cnc(Nc3ccc(C4CCN(CC(N)=O)CC4)cc3)nn12)S(C)(=O)=O CHEMBL1934336 IC50 2.0 nM
CC(C)(C)NS(=O)(=O)c1ccc(-c2cc3c(N)ncc(C(=O)NCCN4CCOCC4)c3s2)cc1 CHEMBL1938659 IC50 2.0 nM
Cc1cc(Nc2nc3cccc(-c4cnn(CC(C)C)c4)n3n2)ccn1 CHEMBL2414532 Ki 2.0 nM
CN1CCN(c2ccc(Nc3nc4cccc(-c5cccc(S(C)(=O)=O)c5)n4n3)cc2)CC1 CHEMBL2414545 Ki 2.0 nM
C[C@H](Nc1nc(Nc2cn(C)cn2)c2cc[nH]c2n1)c1ncc(F)cn1 CHEMBL3116050 IC50 2.0 nM
O=c1[nH]ccc2c(Nc3c(Cl)cncc3Cl)nc3ccncc3c12 CHEMBL3126342 IC50 2.0 nM
CCc1ccc(C(F)(F)F)cc1-c1[nH]c(-c2ccnc(N)n2)cc1C(N)=O CHEMBL3330130 IC50 2.0 nM
COc1ccc(-c2cc(C(N)=O)c3[nH]c4ccc(C(=O)N5CCOCC5)cc4c3c2)cc1 CHEMBL3622196 IC50 2.0 nM
COC(C)(C)c1ccc(Nc2nn([C@H]3CC[C@@H](O)C[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3702947 IC50 2.0 nM
N#C[C@H]1CCCCC1n1cc(C(N)=O)c(Nc2ccc3c(c2)C(O)CS3(=O)=O)n1 CHEMBL3702883 IC50 2.0 nM
N#C[C@H]1C[C@@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@H](O)C(F)(F)F)cc2)n1 CHEMBL3647856 IC50 2.0 nM
N#C[C@H]1CCCCC1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)CF)cc2)n1 CHEMBL3702886 IC50 2.0 nM
CN(C(C1CC1)C1CC1)[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647751 IC50 2.0 nM
[C-]#[N+][C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(/C=N/OC)cc2)n1 CHEMBL3647918 IC50 2.0 nM
CC(C)(c1ccc(Nc2nn([C@H]3CC[C@](C)(O)C[C@@H]3C#N)cc2C(N)=O)cc1)C(O)C(F)(F)F CHEMBL3647835 IC50 2.0 nM
N#C[C@H]1C[C@@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3699499 IC50 2.0 nM
CC(=O)c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3699528 IC50 2.0 nM
C[C@](O)(c1ccc(Nc2nn([C@H]3CC[C@H](O)C[C@@H]3C#N)cc2C(N)=O)cc1)C(F)(F)F CHEMBL3647858 IC50 2.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@H](O)C(F)(F)F)nc2)n1 CHEMBL3699551 IC50 2.0 nM
N#C[C@H]1C[C@H](N2CC(O)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647727 IC50 2.0 nM
[C-]#[N+][C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(/C(C)=N/OC)cc2)n1 CHEMBL3647919 IC50 2.0 nM
CC(C)(c1ccc(Nc2nn([C@H]3CC[C@H](O)C[C@@H]3C#N)cc2C(N)=O)cc1)C(O)C(F)(F)F CHEMBL3647861 IC50 2.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)NCCN3CCCC3)cc2)n1 CHEMBL3702908 IC50 2.0 nM
C[C@@](O)(c1ccc(Nc2nn([C@H]3CC[C@@H](O)C[C@@H]3C#N)cc2C(N)=O)cc1)C(F)(F)F CHEMBL3702953 IC50 2.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@@H](O)C(F)(F)F)cc2)n1 CHEMBL3699537 IC50 2.0 nM
C[C@@](O)(c1ccc(Nc2nn([C@H]3CC[C@@H](N4CCC4)C[C@@H]3C#N)cc2C(N)=O)cc1)C(F)(F)F CHEMBL3703048 IC50 2.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)Nc3ccncc3)cc2)n1 CHEMBL3702902 IC50 2.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)NCc3ccccc3Cl)cc2)n1 CHEMBL3702912 IC50 2.0 nM
N#C[C@@H]1CCCC[C@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)F)cc2)n1 CHEMBL3647922 IC50 2.0 nM
NC(=O)c1cc(-c2ccc(Cl)c(Cl)c2)cc2c1[nH]c1ccc(C(=O)N3CCOC(CO)C3)cc12 CHEMBL3646837 IC50 2.0 nM
COc1ccc(-c2cc(C(N)=O)c3[nH]c4ccc(C(=O)N5CCC[C@H](O)C5)cc4c3c2)cc1F CHEMBL3646839 IC50 2.0 nM
NC(=O)c1cc(-c2ccc(Cl)cc2)nc2c1[nH]c1cc(C(=O)N3CCOCC3)ccc12 CHEMBL3646848 IC50 2.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(C)(=O)=O)cc3)n2)C1 CHEMBL3916939 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2cncnc2)CC1 CHEMBL3932352 IC50 2.0 nM
CNC(=O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1 CHEMBL3977608 IC50 2.0 nM
CC(O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cn1 CHEMBL3968473 IC50 2.0 nM
CN(C)C(=O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1 CHEMBL3904021 IC50 2.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc4c(c3)CNC4=O)n2)CC1 CHEMBL3965904 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ccccc2F)CC1 CHEMBL3945594 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2ccccn2)CC1 CHEMBL3973424 IC50 2.0 nM
COC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)CC1 CHEMBL3958942 IC50 2.0 nM
CC(F)(F)C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1 CHEMBL3920186 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(S(=O)(=O)c2ccco2)CC1 CHEMBL3929554 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(S(=O)(=O)c2cccc(Cl)c2)CC1 CHEMBL3917637 IC50 2.0 nM
CC(C)NC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)CC1 CHEMBL3982094 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)CCC(N2CC(F)C2)CC1 CHEMBL3932064 IC50 2.0 nM
CN(c1ccccc1)C1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1 CHEMBL3914311 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CCC(N2CCC(F)(F)CC2)CC1 CHEMBL3983487 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(Nc2cccc(F)c2)CC1 CHEMBL3916947 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(Nc2ccccc2)CC1 CHEMBL3950965 IC50 2.0 nM
N#CC[C@]1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC[C@@H](NCc2ccccc2)CC1 CHEMBL3928653 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(NCc2ccc(F)cc2F)CC1 CHEMBL3915313 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(NCc2ccccc2Cl)CC1 CHEMBL3897977 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(NCc2ccccc2F)CC1 CHEMBL3943909 IC50 2.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(NCc2ccc(Cl)cc2)CC1 CHEMBL3920570 IC50 2.0 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccnc(F)c2)n1 CHEMBL4067915 IC50 2.0 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL4104623 IC50 2.0 nM
C[C@@H]1NS(=O)(=O)c2ccc(Nc3nn([C@H]4COCC[C@@H]4C#N)cc3C(N)=O)cc21 CHEMBL4066906 IC50 2.0 nM
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCC(C(=O)Nc5ccccc5N)CC4)cc3)n2)cc1 CHEMBL4164238 IC50 2.0 nM
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCC(C(=O)Nc5ccc(C(=O)NO)cc5)CC4)cc3)n2)cc1 CHEMBL4167685 IC50 2.0 nM
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCC(C(=O)NCCCCCCC(=O)NO)CC4)cc3)n2)cc1 CHEMBL4167286 IC50 2.0 nM
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCC(C(=O)NCCCCCCCC(=O)NO)CC4)cc3)n2)cc1 CHEMBL4159366 IC50 2.0 nM
CCCCN(C)C1CCN(c2ccc(Nc3ncc(C)c(-c4cnn(C(C)C)c4)n3)cc2F)CC1 CHEMBL4436572 IC50 2.0 nM
Clc1cccc(Nc2nc(Nc3cn[nH]c3)ncc2Cl)c1 CHEMBL4453646 IC50 2.0 nM
C[C@H](c1ccc(F)cn1)n1c(=O)[nH]c2cnc(Nc3cc(Cl)c[nH]c3=O)nc21 CHEMBL4460058 IC50 2.0 nM
CC(C)Oc1ccc(Cl)cc1-c1nn(C)cc1NC(=O)c1cnn2cccnc12 CHEMBL4794314 Ki 2.0 nM
Cc1cnc(Nc2ccc3c(c2)CN(C(=O)/C=C/C(=O)c2ccccc2)CC3)nc1-c1cnn(C(C)C)c1 CHEMBL4741075 IC50 2.0 nM
COC(=O)/C=C/CN1CCc2cc(Nc3ncc(C)c(-c4cnn(C(C)C)c4)n3)ccc2C1 CHEMBL4754856 IC50 2.0 nM
CO[C@]1(C(=O)N[C@@H](C)c2ccc(-n3cc(F)cn3)nc2)CC[C@H](c2nc(C)cc(Nc3cc(C)[nH]n3)n2)CC1 CHEMBL4582651 IC50 2.0 nM
Cc1cc(Nc2ccc3nc(C)n([C@@H]4CCc5ccc(F)cc54)c3c2)[nH]n1 CHEMBL5282343 IC50 2.0 nM
Cc1cc(Nc2ncc(Cl)c(-c3cnn(CCC#N)c3)n2)sn1 CHEMBL5423566 IC50 2.0 nM
Cc1cnc(Nc2ccc(N3CCOCC3)cc2)nc1-c1cnn(CCC#N)c1 CHEMBL5402073 IC50 2.0 nM
Cc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1-c1cnn(CCC#N)c1 CHEMBL5435482 IC50 2.0 nM
Cc1cc(Nc2ncc(C)c(-c3cnn(CCC#N)c3)n2)sn1 CHEMBL5423027 IC50 2.0 nM
COC[C@H](C)OC(=O)Cc1ccc(Nc2cc(Nc3ccccc3OC)c(C(N)=O)cn2)nc1 CHEMBL5412967 IC50 2.0 nM
CN(CCOc1ccccc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3950892 Ki 2.01 nM
CN(C)CC1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3912946 Ki 2.02 nM
O=C(Nc1cn(CC(=O)N2CCC(NCCc3ccc(Cl)cc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3892396 Ki 2.03 nM
Cc1ccc(OCCN(C)C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)cc1 CHEMBL3918941 Ki 2.03 nM
O=C(Nc1sc(CN2CCCCC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3946179 Ki 2.03 nM
CN(C)C(=O)CNC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3900033 Ki 2.03 nM
O=C(Nc1cn([C@H]2CNCC[C@@H]2O)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3923446 Ki 2.05 nM
CN(CCc1ccc(Cl)cc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3905546 Ki 2.07 nM
CN1CCC(=CCn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3926957 Ki 2.09 nM
Cc1cc(Nc2nc(N3CCN(C(=O)c4ccccc4Br)CC3)nn3cccc23)n[nH]1 CHEMBL1682379 IC50 2.1 nM
COc1ccccc1-c1ccc2cnc(Nc3ccc(S(=O)(=O)N(C)C)cc3)nn12 CHEMBL1923572 IC50 2.1 nM
CN(c1ncccc1-c1ccc2cnc(Nc3ccc(C4CCN(CC(N)=O)CC4)cc3)nn12)S(C)(=O)=O CHEMBL1934344 IC50 2.1 nM
Cc1nc2cnc3[nH]ccc3c2n1C1CCN(CCC#N)CC1 CHEMBL2159143 Ki 2.1 nM
Cc1ccc(C)c(-c2nn(C)cc2NC(=O)c2cnn3cccnc23)c1 CHEMBL2178266 Ki 2.1 nM
CN1CCN(c2ccc3c(c2)[nH]c2c(C(N)=O)cc(-c4ccccc4)cc23)CC1 CHEMBL3589325 IC50 2.1 nM
CCn1c(C(=O)N(C2CC2)C2CC2)cc2c3c(ncn3C)c(Nc3ncc(C)s3)nc21 CHEMBL3622136 IC50 2.1 nM
CC(C)S(=O)(=O)c1ccc(-c2cccn3nc(Nc4ccc(N5CCN(C)CC5)cc4)nc23)cc1 CHEMBL3642289 IC50 2.1 nM
CS(=O)(=O)c1ccc(-c2cccc3nc(Nc4ccc(OCCN5CCCC5)cc4)nn23)cc1 CHEMBL3642305 IC50 2.1 nM
CC1CN(C(=O)CC#N)C12CCN(c1ncnc3[nH]ccc13)C2 CHEMBL3689518 IC50 2.1 nM
O=C(Nc1sc(-c2ccc(CN3CC(F)(F)C3)cc2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3951444 Ki 2.1 nM
O=C1NCN([C@H]2CC[C@H](CNCC(F)(F)Br)CC2)c2c1cnc1[nH]ccc21 CHEMBL3934061 IC50 2.1 nM
CC(C)CN1CCC(NC(=O)Cc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)CC1 CHEMBL4514898 IC50 2.1 nM
CN(C)C[C@@H]1CCCN1C(=O)Cn1cc(NC(=O)c2c(N)nn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3954699 Ki 2.11 nM
CN(CCOc1ccc(Br)cc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3946998 Ki 2.11 nM
Fc1ccc(-n2cc(-c3cccn4nc(Nc5ccc(C6CCNCC6)cc5)nc34)cn2)cc1 CHEMBL3645014 IC50 2.12 nM
CN(Cc1cccc(Oc2ccccc2)c1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3915871 Ki 2.15 nM
CN1CCC(COC(=O)C2(C)CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3924292 Ki 2.16 nM
CN(CC(F)(F)F)C1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3923526 Ki 2.17 nM
Cc1cc(Nc2nc(N3CCN(C(=O)c4ccccc4)CC3)nn3cccc23)n[nH]1 CHEMBL1682371 IC50 2.2 nM
O=C(Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1)[C@H]1CCCN1 CHEMBL2208034 IC50 2.2 nM
CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4ccc(CN5CCOCC5)cc4)nc23)cc1 CHEMBL3642281 IC50 2.2 nM
N#CCC(=O)N1CCC12CCCN(c1ncnc3[nH]ccc13)C2 CHEMBL3689515 IC50 2.2 nM
SC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3927252 IC50 2.2 nM
CC(C)Oc1ccc(CN(C)C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)cc1 CHEMBL3982069 Ki 2.2 nM
CCc1cc(O)ccc1-c1ccc2c(-c3nc4ccccc4[nH]3)n[nH]c2c1 CHEMBL3928932 IC50 2.2 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1n1cc(C#N)c2cnc3[nH]ccc3c21 CHEMBL5267452 IC50 2.2 nM
COC(=O)C1(C)CCN(CCN2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3895560 Ki 2.22 nM
CN(CCOc1ccccc1Cl)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3961979 Ki 2.29 nM
O=C(Nc1cn(CC(=O)N2CCC(C(=O)N3CCNCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3892301 Ki 2.29 nM
CCCS(=O)(=O)N1CCc2cc(Nc3ncc(C)c(-c4cnn(C(C)C)c4)n3)ccc21 CHEMBL4845758 IC50 2.29 nM
Brc1ncc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)s1 CHEMBL3931093 IC50 2.3 nM
COCCn1cc(-c2nc(Nc3ccc(NC(=O)CCCCCCC(=O)NO)cc3)nc3[nH]ccc23)cn1 CHEMBL4250891 IC50 2.3 nM
O=c1[nH]cc(F)cc1Nc1ncc2[nH]c(=O)n([C@@H]3CCOc4c(F)cccc43)c2n1 CHEMBL4526498 IC50 2.3 nM
O=C(O)CCCCCCC(=O)Nc1ccc(NCCOc2ccc3cc2COC/C=C/COCc2cccc(c2)-c2ccnc(n2)N3)cc1 CHEMBL3964125 IC50 2.31 nM
CN(C)CCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3939335 Ki 2.33 nM
CN1CCC2(CC1)CN(C(=O)Cn1cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n1)CCO2 CHEMBL3966652 Ki 2.34 nM
CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4cccc(N5CCN(CCO)CC5)c4)nc23)cc1 CHEMBL3642375 IC50 2.37 nM
CC(C)(C)OC(=O)N1CC[C@@H](O)[C@H](n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL4109287 Ki 2.37 nM
CN(C)CC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3896994 Ki 2.38 nM
CN1CCCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3975210 Ki 2.38 nM
CN1C[C@@H]2CN(C(=O)c3nc(-c4cc(Cl)ccc4OC(F)F)c(NC(=O)c4cnn5cccnc45)s3)C[C@@H]2C1 CHEMBL3890152 Ki 2.38 nM
Cc1cnc(Nc2ccc3c(c2)CCN3S(=O)(=O)C2CC2)nc1-c1cnn(C(C)C)c1 CHEMBL4849458 IC50 2.38 nM
Cc1cc(Nc2nc(N3CCN(C(=O)Cc4ccc(F)cc4F)CC3)nn3cccc23)n[nH]1 CHEMBL1682387 IC50 2.4 nM
NC(=O)c1cc(-c2ccc(Cl)c(Cl)c2)cc2c1[nH]c1ccc(C(=O)N3CCOCC3)cc12 CHEMBL3589164 IC50 2.4 nM
CN1CCN(c2ccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)cc2)CC1 CHEMBL2062805 IC50 2.4 nM
CN1CCN(Cc2ccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)cc2)CC1 CHEMBL3642282 IC50 2.4 nM
N#CCC(=O)N1CCC[C@H](n2c(=O)[nH]c3cnc(Nc4cc(Cl)c[nH]c4=O)nc32)C1 CHEMBL4443416 IC50 2.4 nM
O=C(Nc1c[nH]nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cc(F)cnc12 CHEMBL4755436 Ki 2.4 nM
CN(C)CC1(O)CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3918506 Ki 2.42 nM
CN1CCC(COC(=O)C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3892798 Ki 2.42 nM
CCCCOc1ccc(CN(C)C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)cc1 CHEMBL3975956 Ki 2.44 nM
O=C(CCCCOc1ccc2cc1COC/C=C/COCc1cccc(c1)-c1ccnc(n1)N2)NO CHEMBL3980203 IC50 2.45 nM
O=C(Nc1cn(CC(=O)N2CCC(N3CCCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3892717 Ki 2.45 nM
CCCCN(CC(F)(F)F)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3897207 Ki 2.48 nM
CN(CCOc1ccc(Cl)cc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3913096 Ki 2.49 nM
CCOC(=O)CCN(C)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3929711 Ki 2.49 nM
CN(c1ccccc1-c1cc(Cl)c2cnc(Nc3ccc(C4CCN(CC(N)=O)CC4)cc3)nn12)S(C)(=O)=O CHEMBL1934353 IC50 2.5 nM
Cc1cc(NC(=O)c2cnn3ccc(N)nc23)n(-c2cccc(Cl)c2)n1 CHEMBL2178807 Ki 2.5 nM
CCn1c(C(=O)N(C2CC2)C2CC2)cc2c3c(ncn3C)c(Nc3nc(C)c(C)s3)nc21 CHEMBL3622137 IC50 2.5 nM
COc1ccc(Cl)cc1-c1nn(CC(=O)N2CC=CCC2)cc1NC(=O)c1cnn2cccnc12 CHEMBL3667523 Ki 2.5 nM
N#CCCN(CCC#N)C1CCC(c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3953229 IC50 2.5 nM
N#CC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3900105 IC50 2.5 nM
Cc1cnc(Nc2cnn(C)c2)nc1-c1cnn(CCC#N)c1 CHEMBL5438892 IC50 2.5 nM
Cc1cc(Nc2ncc(C)c(N3CC(O)(C4CC4)C3)n2)sn1 CHEMBL5434489 IC50 2.5 nM
CN(C)C(=O)CN1CCC(CN2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3982869 Ki 2.51 nM
CCN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1967998 pKi 2.512 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1979690 pKi 2.512 nM
CCc1cc(O)c(F)cc1-c1cc(NC[C@@H](C)O)c2nc(N)ncc2c1 CHEMBL5079248 pIC50 2.512 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@@H](C)CO)c2nc(NCCCN(C)C)ncc2c1 CHEMBL5076101 pIC50 2.512 nM
CCOC(=O)C1(C)CCN(CCN2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1 CHEMBL3950272 Ki 2.52 nM
O=C(O)CCCCCCOc1ccc2cc1COC/C=C/COCc1cccc(c1)-c1ccnc(n1)N2 CHEMBL3920872 IC50 2.57 nM
O=C(Nc1cn(CC(=O)N2CCC(NCCc3ccc(C(F)(F)F)cc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3957933 Ki 2.58 nM
NC(=O)c1cc(-c2ccccc2)cc2c1[nH]c1ccc(C(=O)N3CCOCC3)cc12 CHEMBL3589165 IC50 2.6 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1n1c(=O)[nH]c2cnc3[nH]ccc3c21 CHEMBL3593591 IC50 2.6 nM
NC(=O)c1cc(-c2ccc(Cl)cc2)cc2c1[nH]c1ccc(C(=O)N3CCOCC3)cc12 CHEMBL3622197 IC50 2.6 nM
COc1ccc(C#N)cc1-c1nn(Cc2nncn2C)cc1NC(=O)c1cnn2cccnc12 CHEMBL3667517 Ki 2.6 nM
COc1ccc(CCN(C)C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)cc1 CHEMBL3966370 Ki 2.6 nM
CC(=O)Nc1ccc(-c2ccnc(Nc3cccc(NC(=O)CCCCC(=O)NO)c3)n2)cc1 CHEMBL4284388 IC50 2.6 nM
C[C@H]1CN(C(=O)CC#N)[C@]12CCN(c1ncnc3[nH]ccc13)C2 CHEMBL4297507 IC50 2.6 nM
COc1ccc(Cl)cc1-c1nn(C)cc1NC(=O)c1cncc2[nH]cnc12 CHEMBL4745011 Ki 2.6 nM
CC(=O)Nc1ccc(-c2ccnc(NCc3ccc(OCCCCCC(=O)NO)cc3)n2)cc1 CHEMBL5274303 IC50 2.6 nM
C[C@H]1CC(C(=O)CC#N)[C@]12CCN(c1ncnc3[nH]ccc13)C2 CHEMBL5421204 IC50 2.6 nM
CN1CCN(c2ccc(Nc3nc4c(C#Cc5ccccc5N(C)S(C)(=O)=O)cccn4n3)cc2)CC1 CHEMBL3642410 IC50 2.61 nM
CC(C)(O)CN1CCN(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)CC1 CHEMBL3642367 IC50 2.61 nM
O=C(Nc1cn(CC(=O)N2CCC(C(=O)OCC3CCNCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3907971 Ki 2.62 nM
N#CCN1CCC(Nc2c(-c3cn[nH]c3)cnc3[nH]ccc23)CC1 CHEMBL5436383 IC50 2.641 nM
CN(C)C1CCN(Cc2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3910933 Ki 2.65 nM
CN1CC[C@H]2[C@@H](CCN2C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3925919 Ki 2.68 nM
CN(Cc1ccc(F)c(Br)c1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3902522 Ki 2.68 nM
N[C@H](CO)C(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL2208033 IC50 2.7 nM
Clc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)s1 CHEMBL3949285 IC50 2.7 nM
O=C(Nc1cn([C@H]2CCNC[C@@H]2O)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3896379 Ki 2.7 nM
CN1CN([C@H]2CC[C@H](CNS(C)(=O)=O)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3919463 IC50 2.7 nM
N#Cc1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)cc1Cl CHEMBL4085737 IC50 2.7 nM
Cc1cnc(Nc2ccccc2)nc1-c1cc2c(o1)CCN(S(C)(=O)=O)C2 CHEMBL4453064 IC50 2.7 nM
O=C(Nc1cn(CC(=O)N2CC3(CCNC3)C2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3952559 Ki 2.71 nM
N#CCCN1CCC(Nc2c(-c3cn[nH]c3)cnc3[nH]ccc23)CC1 CHEMBL5419271 IC50 2.716 nM
CCS(=O)(=O)N1CCc2cc(Nc3ncc(C)c(-c4cnn(C(C)C)c4)n3)ccc21 CHEMBL4867814 IC50 2.72 nM
CN(C)C(=O)[C@@H]1CCCN1CC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3890546 Ki 2.79 nM
Cc1cc(Nc2nc(N3CCN(C(=O)Cc4ccccc4)CC3)nn3cccc23)n[nH]1 CHEMBL1682367 IC50 2.8 nM
COc1cccc(-c2cc(C(N)=O)c3[nH]c4ccc(C(=O)N5CCOCC5)cc4c3c2)c1 CHEMBL3589166 IC50 2.8 nM
CN1CCN(c2cccc(Nc3nc4cccc(-c5ccc(S(C)(=O)=O)cc5)n4n3)c2)CC1 CHEMBL3642321 IC50 2.8 nM
CN1CCN(c2ccc(Nc3nc4cccc(-c5ccc(NS(C)(=O)=O)cc5)n4n3)cc2)CC1 CHEMBL3642313 IC50 2.8 nM
CC(=O)SC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3905627 IC50 2.8 nM
Brc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)o1 CHEMBL3979340 IC50 2.8 nM
FC(F)(Br)CN[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3943928 IC50 2.8 nM
N#CC[C@H]1CC[C@H](n2c(CC(=O)NC34CCC(C(N)=O)(CC3)CC4)nc3cnc4[nH]ccc4c32)CC1 CHEMBL4447497 IC50 2.8 nM
CCn1cc(Nc2nc3c(-c4ccc(C(F)(F)F)cc4)cccn3n2)cn1 CHEMBL3644963 IC50 2.84 nM
Cc1nc2cnc3[nH]ccc3c2n1C1CCN(Cc2ccccc2)CC1 CHEMBL2159142 Ki 2.9 nM
CN1CCN(c2ccc3c(c2)[nH]c2c(C(N)=O)cc(-c4cccc(Cl)c4)cc23)CC1 CHEMBL3589326 IC50 2.9 nM
C[N+](C)(CCCc1ccccc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3953340 Ki 2.9 nM
CC(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCCCC4)cc3)n2)cc1 CHEMBL4279986 IC50 2.9 nM
Cc1cnc(Nc2ccccc2)nc1-c1cc2c(o1)CCN(C(=O)CC#N)C2 CHEMBL4583532 IC50 2.9 nM
CC(=O)c1ccc(NC(=O)N2CCN(c3ccnc(Nc4ccc(N5CCOCC5)cc4)n3)CC2)cc1 CHEMBL4581423 IC50 2.9 nM
CN(Cc1ccc2ccccc2c1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3919674 Ki 2.91 nM
CN(C)CCC1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3944383 Ki 2.92 nM
CC(=O)Nc1ccc(-c2nc(Nc3cccc(OCCCCCCCC(=O)NO)c3)ncc2C)cc1 CHEMBL4290689 IC50 2.93 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCN(Cc2ccc(Cl)cc2)[C@@H](C)C1 CHEMBL4783938 IC50 2.94 nM
COc1cc(Nc2cncc(N[C@@H](C)c3ccc(F)cn3)n2)n[nH]1 CHEMBL570464 IC50 3.0 nM
Cc1cc(Nc2cnc(C#N)c(N[C@@H](C)c3ccc(F)cn3)n2)n[nH]1 CHEMBL576257 IC50 3.0 nM
Cc1cc(Nc2cncc(N[C@@H](C)c3ccc(F)cn3)n2)n[nH]1 CHEMBL569738 IC50 3.0 nM
Cc1cc(Nc2cncc(N[C@@H](C)c3ncc(F)cn3)n2)n[nH]1 CHEMBL570899 IC50 3.0 nM
OCc1ccc(C2Nc3ccccc3-c3ccnc4[nH]cc2c34)cc1 CHEMBL592034 Ki 3.0 nM
Cc1cnc(Nc2cc(N3CCOCC3)nc(N[C@@H](C)c3ncc(F)cn3)n2)s1 CHEMBL1088030 IC50 3.0 nM
COc1cc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)ccc1O CHEMBL1078274 IC50 3.0 nM
COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Cl)n[nH]1 CHEMBL1650723 IC50 3.0 nM
C[C@H](Nc1ncc(F)c(Nc2cc(C3CC3)[nH]n2)n1)c1ncc(F)cn1 CHEMBL1650698 IC50 3.0 nM
Cc1cc(Nc2nc(N3CCN(C(=O)c4ccccc4C)CC3)nn3cccc23)n[nH]1 CHEMBL1682373 IC50 3.0 nM
C[C@H](Nc1nc(Nc2cc(C3CC3)[nH]n2)c(F)cc1C#N)c1ccc(F)cc1 CHEMBL1774053 IC50 3.0 nM
O=c1[nH]ccc2c3[nH]c(-c4ccccc4Cl)nc3c3ccc(F)cc3c12 CHEMBL261386 IC50 3.0 nM
CC(C)C(Nc1ncc(C(N)=O)c2[nH]c3cc(-c4cnn(C)c4)ccc3c12)C1CC1 CHEMBL1835140 IC50 3.0 nM
NC(=O)c1cnc(NC(C2CC2)C2CC2)c2c1[nH]c1cc(-c3cn[nH]c3)ccc12 CHEMBL1835146 IC50 3.0 nM
CC(C)[C@@H](Nc1ncc(C(N)=O)c2[nH]c3cc(-c4cnn(C)c4)ccc3c12)C(F)(F)F CHEMBL1835144 IC50 3.0 nM
COCCNC(=O)c1cnc(N)c2cc(-c3ccc(S(=O)(=O)NC(C)(C)C)cc3)sc12 CHEMBL1938656 IC50 3.0 nM
Cc1cc(-c2ccc3nc(Nc4ccccc4)nn3c2)cc(C)c1C CHEMBL2171747 Ki 3.0 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)c(F)c(N3CCN(S(C)(=O)=O)CC3)n2)n[nH]1 CHEMBL2381975 IC50 3.0 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)c(F)c(N3CCS(=O)(=O)CC3)n2)n[nH]1 CHEMBL2381986 IC50 3.0 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)c(F)c(N3CCOCC3)n2)n[nH]1 CHEMBL2381979 IC50 3.0 nM
CCn1cc(-c2cccc3nc(Nc4ccnc(CO)c4)nn23)cn1 CHEMBL2414531 Ki 3.0 nM
N#C[C@H]1CCC[C@H]1Nc1nc(-c2ccccc2)nc2c(=O)[nH]ccc12 CHEMBL2436943 Ki 3.0 nM
C[C@H](Nc1nc(Nc2cn(C)cn2)c2ccccc2n1)c1ncc(F)cn1 CHEMBL3116058 IC50 3.0 nM
O=c1[nH]ccc2c(Nc3c(Cl)cc(OC(F)(F)F)cc3Cl)nc3ccncc3c12 CHEMBL3126343 IC50 3.0 nM
CCc1ccc(Cl)cc1-c1[nH]c(-c2ccnc(N)n2)cc1C(N)=O CHEMBL3330129 IC50 3.0 nM
CCc1ccc(Cl)cc1-c1cc(-c2ncnc3[nH]ccc23)[nH]c1C(N)=O CHEMBL3403553 IC50 3.0 nM
CS(=O)(=O)c1ccc(Nc2nn([C@@H]3CCCC[C@H]3C#N)cc2C(N)=O)cc1 CHEMBL3650683 IC50 3.0 nM
N#C[C@H]1C[C@@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@@H](O)C(F)(F)F)cc2)n1 CHEMBL3647857 IC50 3.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C=O)cc2)n1 CHEMBL3699526 IC50 3.0 nM
N#C[C@H]1C[C@H](O)CCC1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)F)cc2)n1 CHEMBL3699500 IC50 3.0 nM
CC1(O)CN([C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3647771 IC50 3.0 nM
COc1ccc(Nc2nc3c(-c4cnn(S(C)(=O)=O)c4)cccn3n2)cc1 CHEMBL3642280 IC50 3.0 nM
C[C@](O)(c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cn1)C(F)F CHEMBL3699540 IC50 3.0 nM
N#Cc1ccc(Nc2nn([C@H]3CC[C@H](O)C[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3647852 IC50 3.0 nM
CC(C)(c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1)[C@H](O)C(F)(F)F CHEMBL3699530 IC50 3.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)N3CCC4(CC3)OCCO4)cc2)n1 CHEMBL3702913 IC50 3.0 nM
N#Cc1ccc(Nc2nn([C@H]3CC[C@@H](O)C[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3702941 IC50 3.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@@H](O)C(F)(F)F)nc2)n1 CHEMBL3699547 IC50 3.0 nM
N#C[C@H]1CC(NC2COC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647731 IC50 3.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1N1CCc2nc(Nc3ccc(C(=O)N4CCN(C)CC4)nc3)ncc2C1 CHEMBL3658108 IC50 3.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1N1CCc2nc(Nc3ccc(C(=O)N4CCN(C)CC4)cc3)ncc2C1 CHEMBL3658087 IC50 3.0 nM
N#C[C@H]1C[C@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@H](O)C(F)(F)F)cc2)n1 CHEMBL3702949 IC50 3.0 nM
CS(=O)(=O)c1cccc(-c2cccn3nc(Nc4ccc(OCCN5CCCC5)cc4)nc23)c1 CHEMBL3642259 IC50 3.0 nM
Cc1cc(-n2cnc3ccc(N[C@@H](C)c4ccc(F)cn4)nc32)n[nH]1 CHEMBL3659504 IC50 3.0 nM
CC(C)CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3nc[nH]c3n2)C1 CHEMBL3665163 IC50 3.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@H](O)C(F)F)nc2)n1 CHEMBL3699538 IC50 3.0 nM
CS(=O)(=O)c1ccc(Nc2nn([C@H]3CC[C@@H](O)C[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3702957 IC50 3.0 nM
N#C[C@H]1C[C@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@@H](O)C(F)(F)F)cc2)n1 CHEMBL3702951 IC50 3.0 nM
N#C[C@H]1C[C@@H](NC2COC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(CC(F)(F)F)cc2)n1 CHEMBL3703051 IC50 3.0 nM
N#C[C@H]1C[C@H](O)CCC1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647924 IC50 3.0 nM
N#C[C@H]1C[C@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3650684 IC50 3.0 nM
BrC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3918308 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2ccc(C#N)cc2)CC1 CHEMBL3895654 IC50 3.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(C)(C)O)nc3)n2)CC1 CHEMBL3951123 IC50 3.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(C)(C)O)cc3)n2)CC1 CHEMBL3938918 IC50 3.0 nM
CC(=O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1 CHEMBL3901812 IC50 3.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(=O)C(F)(F)F)cc3)n2)CC1 CHEMBL3974477 IC50 3.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(N)c3)n2)CC1 CHEMBL3985138 IC50 3.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(Cl)c3)n2)CC1 CHEMBL3917002 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(OC4CCC4)nc3)n2)CCN(C(=O)OCC(F)F)CC1 CHEMBL3971587 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(C4CCC4)nc3)n2)CCN(C(=O)OCC(F)F)CC1 CHEMBL3945622 IC50 3.0 nM
COC(=O)Cc1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1 CHEMBL3968445 IC50 3.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(N4CCOCC4)nc3)n2)CC1 CHEMBL3912678 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2cccc(F)c2)CC1 CHEMBL3914149 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)CCN(C(=O)OC2COC2)CC1 CHEMBL3924793 IC50 3.0 nM
CCC(F)(F)C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1 CHEMBL3986976 IC50 3.0 nM
CS(=O)(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1 CHEMBL3906783 IC50 3.0 nM
COc1ccc(S(=O)(=O)N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccccc4)n3)CC2)cc1 CHEMBL3978603 IC50 3.0 nM
COc1cccc(S(=O)(=O)N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccccc4)n3)CC2)c1 CHEMBL3893139 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(S(=O)(=O)C2CC2)CC1 CHEMBL3903172 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)cc3)n2)CCC(N2CC(F)C2)CC1 CHEMBL3938195 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc([S+]([O-])C(F)F)cc3)n2)CCC(Nc2ccc(O)cc2)CC1 CHEMBL3902507 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(Nc2ccc(Cl)cc2)CC1 CHEMBL3942031 IC50 3.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CCC(NCC(F)F)CC1 CHEMBL3940414 IC50 3.0 nM
N#C[C@@H]1CCOC[C@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)F)nc2)n1 CHEMBL3934877 IC50 3.0 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(OCC(F)(F)F)nc2)n1 CHEMBL4113597 IC50 3.0 nM
N#C[C@@H]1CCOC[C@H]1n1cc(C(N)=O)c(Nc2ccccc2)n1 CHEMBL3916138 IC50 3.0 nM
Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(c5ccc(C#N)cn5)CC4C3)n2)cn1 CHEMBL3943922 IC50 3.0 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccccc2)n1 CHEMBL4100288 IC50 3.0 nM
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCC(C(=O)NCCCCCC(=O)NO)CC4)cc3)n2)cc1 CHEMBL4160833 IC50 3.0 nM
O=C(CCCCCCC(=O)Nc1ccc(Nc2nc(-c3cnn(CC4CCCC4)c3)c3cc[nH]c3n2)cc1)NO CHEMBL4250122 IC50 3.0 nM
Cc1cnc(Nc2ccc(N3CCC(N(C)CCN4CCN(C)CC4)CC3)c(F)c2)nc1-c1cnn(C(C)C)c1 CHEMBL4461809 IC50 3.0 nM
COc1ccc(F)cc1C(C)Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N CHEMBL4465076 IC50 3.0 nM
C[C@@H](Oc1cc(-c2cnn(C3CCOCC3)c2)cnc1N)c1cc(F)ccc1Cl CHEMBL4634591 IC50 3.0 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc([S+]([O-])NC(C)(C)C)c1 CHEMBL4637972 IC50 3.0 nM
Cc1cnc(Nc2ccc3c(c2)CCN(C(=O)/C=C/CN(C)C)C3)nc1-c1cnn(C(C)C)c1 CHEMBL4753549 IC50 3.0 nM
Cc1ccc(C(=O)/C=C/C(=O)N2CCc3cc(Nc4ncc(C)c(-c5cnn(C(C)C)c5)n4)ccc3C2)cc1 CHEMBL4759953 IC50 3.0 nM
Cc1cnc(Nc2ccc3c(c2)CCN3C(=O)CN2CCS(=O)(=O)CC2)nc1-c1cnn(C(C)C)c1 CHEMBL4862108 IC50 3.0 nM
Cc1cnc(Nc2ccc3c(c2)CCN3C(=O)[C@H]2CCCN2)nc1-c1cnn(C(C)C)c1 CHEMBL4873455 IC50 3.0 nM
Cc1cc(Nc2cc(CN3CCOCC3)c3nc(C)c(Cc4ccc(Cl)cc4F)n3n2)n[nH]1 CHEMBL2107823 IC50 3.0 nM
Cc1cnc(Nc2ccc(N3CCC(N4CCOCC4)CC3)cc2)nc1-c1ccc(C(=O)NCC#N)cc1 CHEMBL5175300 IC50 3.0 nM
N#CCNC(=O)c1ccc(-c2nc(Nc3ccc(N4CCC(N5CCOCC5)CC4)cc3)ncc2Cl)cc1 CHEMBL5189266 IC50 3.0 nM
Cc1cnc(Nc2ccc(CNC(=O)CCl)cc2)nc1-c1cnn(C(C)C)c1 CHEMBL5440964 IC50 3.0 nM
Cc1cc(Nc2ncc(C)c(N3CCN(CC#N)C(C)C3)n2)sn1 CHEMBL5429675 IC50 3.0 nM
CN1CCN(Cc2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)CC1 CHEMBL2062806 IC50 3.07 nM
CN1CC2(CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)C1 CHEMBL3957787 Ki 3.08 nM
CN(Cc1cccc(C(F)(F)F)c1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3914169 Ki 3.09 nM
CCCN(CC(F)(F)F)C(=O)C1CCCN(c2cc(-c3c(N)nn4cccnc34)ncn2)C1 CHEMBL569957 IC50 3.1 nM
Cc1cc(-c2cnc3cccc(-c4cc(F)c(CN5CCOCC5)c(F)c4)c3n2)ccc1C(=O)N1CCOCC1 CHEMBL1093119 IC50 3.1 nM
CN(C)[C@H]1CCN(C(=O)c2ccc3[nH]c4c(C(N)=O)cc(-c5ccc(Cl)c(Cl)c5)cc4c3c2)C1 CHEMBL3589170 IC50 3.1 nM
CCn1c(C(=O)N(C2CC2)C2CC2)cc2c3c(ncn3C)c(Nc3nc(C(=O)NC)c(C)s3)nc21 CHEMBL3622144 IC50 3.1 nM
CN1CCN(c2ccc(Nc3nc4c(-c5ccc(C(F)(F)F)cc5)cccn4n3)cc2)CC1 CHEMBL3642297 IC50 3.1 nM
COc1ccc(Cl)cc1-c1nn(CC(=O)N2CCCC2C)cc1NC(=O)c1cnn2cccnc12 CHEMBL3667522 Ki 3.1 nM
CN(CC(F)(F)F)C[C@H]1CC[C@H](N2CN(C)C(=O)c3cnc4[nH]ccc4c32)CC1 CHEMBL3892444 IC50 3.1 nM
O=C(CCCCCCC(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1)NO CHEMBL4286867 IC50 3.1 nM
COc1cc2c(=O)n([C@@H]3CCCN(C(=O)CC#N)C3)c3c4cc[nH]c4ncc3c2cc1OC CHEMBL4290597 IC50 3.12 nM
CN(CCOc1ccccc1Br)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3907313 Ki 3.17 nM
O=C(Nc1c[nH]nc1-c1cccc(Cl)c1)c1cnn2cccnc12 CHEMBL2178253 Ki 3.2 nM
Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cccc(Cl)c2)n1 CHEMBL2178252 Ki 3.2 nM
N#Cc1ccc(N2CC[C@@H](Nc3c(C(N)=O)cnc4[nH]ccc34)[C@@H](F)C2)nc1 CHEMBL3593777 IC50 3.2 nM
CS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL3645121 IC50 3.2 nM
CS(=O)(=O)c1cccc(-c2cccc3nc(Nc4ccc(N5CCOCC5)cc4)nn23)c1 CHEMBL3642309 IC50 3.2 nM
Cc1cc(NC(=O)c2cnn3ccc(Nc4cccc(C(F)(F)F)c4)nc23)on1 CHEMBL3670392 Ki 3.2 nM
COc1cc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)ccc1C#N CHEMBL4072848 IC50 3.2 nM
O=c1[nH]cccc1Nc1ncc2[nH]c(=O)n([C@@H]3CCOc4c(F)cccc43)c2n1 CHEMBL4558494 IC50 3.2 nM
Cc1nccc(Nc2cc(NC3CCN(c4ccc(C#N)cn4)CC3)c(C(N)=O)cn2)n1 CHEMBL4591633 IC50 3.2 nM
NC[C@@H]1CCCN1C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1 CHEMBL3927987 Ki 3.24 nM
CCOC(=O)CN(CCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1)Cc1cccnc1 CHEMBL3910888 Ki 3.27 nM
CN(CC(F)(F)F)C1CCN(C(=O)c2ccc(-n3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)cc2)CC1 CHEMBL3924554 Ki 3.28 nM
C[C@@H](NC(=O)c1c[nH]c2ncc(-c3cn(C)c4cc(Cl)ccc34)nc12)C(=O)N1CC(C#N)C1 CHEMBL2376143 IC50 3.3 nM
CN1CCN(c2ccc(Nc3nc4c(-c5cccc(S(C)(=O)=O)c5)cccn4n3)cc2)CC1 CHEMBL3642293 IC50 3.3 nM
Cc1cc(NC(=O)c2cnn3cccnc23)n(-c2cc(Cl)ccc2Cl)n1 CHEMBL3667510 Ki 3.3 nM
CCc1cc(O)ccc1-c1ccc2c(-c3nc4c([nH]3)CN(C(C)=O)CC4)n[nH]c2c1 CHEMBL4093813 IC50 3.3 nM
Cc1ccc(CN(C)C2CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)c(C)c1 CHEMBL3980794 Ki 3.33 nM
Nc1nn2cccnc2c1-c1cc(N2CCCC2c2ccc(F)cc2)ncn1 CHEMBL582808 IC50 3.4 nM
CN(C)c1cc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)cc(F)n1 CHEMBL4092626 IC50 3.4 nM
CC(=O)Nc1ccc(-c2ccnc(Nc3cccc(OCCCCCC(=O)NO)c3)n2)cc1 CHEMBL4280540 IC50 3.4 nM
COCC1CN(C2CCN(c3cc(OC)c(Nc4ncc(Br)c(Nc5ccc6c(c5P(C)(C)=O)OCCO6)n4)cc3C)CC2)C1 CHEMBL5188373 IC50 3.4 nM
Cc1cc(Nc2ncc(C)c(N3CCN(CC#N)CC3)n2)sn1 CHEMBL5402554 IC50 3.4 nM
Cc1cnc(Nc2cnn(C)c2)nc1N1CC2CCCC(C1)N2CCC#N CHEMBL5412619 IC50 3.4 nM
Cc1cc(Nc2ncc(C)c(N3CC(C4CC4)C3)n2)sn1 CHEMBL5403288 IC50 3.4 nM
CC(=O)Nc1cccc(Nc2nc3c(-c4ccc(S(C)(=O)=O)cc4)cccn3n2)c1 CHEMBL3644999 IC50 3.43 nM
CN(C)C(=O)[C@@H]1CCCN1C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3894039 Ki 3.44 nM
COc1ccccc1C(=O)N1CCN(c2nc(Nc3cc(C)[nH]n3)c3cccn3n2)CC1 CHEMBL1682377 IC50 3.5 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 3.5 nM
COc1cccc(-c2cc(C(N)=O)c3[nH]c4cc(C(=O)N5CC[C@H](N(C)C)C5)ccc4c3c2)c1 CHEMBL3589177 IC50 3.5 nM
COc1cccc(-c2cc(C(N)=O)c3[nH]c4ccc(C(=O)N5CCN(C)CC5)cc4c3c2)c1 CHEMBL3589171 IC50 3.5 nM
Cc1cc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)ccn1 CHEMBL4073562 IC50 3.5 nM
Cc1nccc(Nc2cc(NC3CCN(c4ccc(C#N)cc4)CC3)c(C(N)=O)cn2)n1 CHEMBL4463436 IC50 3.5 nM
Cn1ncc(NC(=O)c2cnn3cccnc23)c1-c1cc(Cl)ccc1Cl CHEMBL4786888 Ki 3.5 nM
C[C@@H]1CCN(C(=O)Cn2cnnn2)C[C@@H]1n1c(=O)[nH]c2cnc3[nH]ccc3c21 CHEMBL5268959 IC50 3.5 nM
COc1cc2c(=O)n(CC3CCCCC3)c3c4cc[nH]c4ncc3c2cc1OC CHEMBL4284499 IC50 3.57 nM
CCCN(CC)C(=O)C1CCCN(c2cc(-c3c(N)nn4cccnc34)ncn2)C1 CHEMBL569757 IC50 3.6 nM
Cc1cc(-c2ccccc2N(C)S(C)(=O)=O)n2nc(Nc3ccc(C4CCN(CC(N)=O)CC4)cc3)ncc12 CHEMBL1934352 IC50 3.6 nM
CC(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL1077458 IC50 3.6 nM
CC[C@@H]1CCCC[C@@H]1n1c(=O)[nH]c2cnc3[nH]ccc3c21 CHEMBL3593584 IC50 3.6 nM
CC(=O)Nc1ccc(-c2ccnc(Nc3cccc(OCCCCCCC(=O)NO)c3)n2)cc1 CHEMBL4294153 IC50 3.6 nM
N#CC[C@H]1CC[C@H](n2c(=O)[nH]c3cnc(Nc4cc(Cl)c[nH]c4=O)nc32)CC1 CHEMBL4526485 IC50 3.6 nM
Cc1cnc(Nc2ccc(C3CCN(C)CC3)c(F)c2)nc1Nc1ccc2c(c1)N(S(=O)(=O)C(C)(C)C)CC2 CHEMBL4762807 IC50 3.6 nM
CN(c1ncnc2[nH]ccc12)N1CCC[C@@H](C(=O)NCC#N)C1 CHEMBL5191898 IC50 3.6 nM
CCCCN(CCOc1ccc(C)cc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3961634 Ki 3.66 nM
CN1CCN(c2ccc(Nc3ncc4ccc(-c5ccccc5N(C)S(C)(=O)=O)n4n3)cc2F)CC1 CHEMBL1923581 IC50 3.7 nM
N#CCCN1CCC(n2nnc3cnc4[nH]ccc4c32)CC1 CHEMBL2392488 Ki 3.7 nM
CN1CCN(c2cccc(Nc3nc4c(-c5ccc(C(F)(F)F)cc5)cccn4n3)c2)CC1 CHEMBL2062811 IC50 3.7 nM
c1cc2c(ncn3nnc(C4CCN(Cc5csnn5)CC4)c23)[nH]1 CHEMBL3894161 IC50 3.7 nM
Cc1cnc(Nc2cc(F)c(N3CCOCC3)c(F)c2)nc1-c1cc2c(o1)CCN(S(C)(=O)=O)C2 CHEMBL4456396 IC50 3.7 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(Cl)cc2)[C@H](C)C1 CHEMBL4761365 IC50 3.7 nM
CC(C)(C)OC(=O)N1CCN(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)CC1 CHEMBL3642400 IC50 3.72 nM
CN(CCc1ccccc1)C1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3907485 Ki 3.72 nM
CC(C)(C)OC(=O)N1CC[C@H](n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)[C@@H](O)C1 CHEMBL3921889 Ki 3.72 nM
CN(Cc1ccccc1)C1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3892543 Ki 3.76 nM
O[C@]12C[C@H]3C[C@H](C[C@H](C1)[C@@H]3Nc1c(-c3cn[nH]c3)cnc3[nH]ccc13)C2 CHEMBL5437654 IC50 3.783 nM
CCCC(=O)N1CCC(Nc2c(-c3cn[nH]c3)cnc3[nH]ccc23)CC1 CHEMBL5398468 IC50 3.783 nM
N#CCC(=O)N1CCC[C@@H](n2nnc3cnc4[nH]ccc4c32)C1 CHEMBL2392500 Ki 3.8 nM
Cc1cnc(Nc2ccc3c(c2)CCN3C(=O)[C@H]2CCCN2C(=O)C2(C#N)CC2)nc1-c1cnn(C(C)C)c1 CHEMBL4873733 IC50 3.8 nM
Cc1cnc(Nc2ccc3c(c2)CCN3C(=O)C2CC2)nc1-c1cnn(C(C)C)c1 CHEMBL4854704 IC50 3.86 nM
CN(C)C(=O)CN1CCC(c2ccc(Nc3nc4c(-c5ccc(C#N)cc5)cccn4n3)cc2)CC1 CHEMBL3645072 IC50 3.88 nM
COc1cc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)ccc1Cl CHEMBL4071005 IC50 3.9 nM
CC(=O)Nc1ccc(-c2nc(Nc3cccc(OCCCCCCC(=O)NO)c3)ncc2C)cc1 CHEMBL4295224 IC50 3.9 nM
Cc1cc(Nc2ncc(C)c(N3CCC(CC#N)CC3)n2)sn1 CHEMBL5434965 IC50 3.9 nM
Cc1cc(Nc2ncc(C)c(N3CC4CCC(C3)N4CC#N)n2)sn1 CHEMBL5402797 IC50 3.9 nM
Cc1cc(Nc2ncc(C)c(N3CC(CC#N)(N4CCN(C)CC4)C3)n2)sn1 CHEMBL5396135 IC50 3.9 nM
CN(C)c1cccc(-c2cccn3nc(Nc4ccc(C5CCNCC5)cc4)nc23)c1 CHEMBL3645077 IC50 3.93 nM
Cc1cc(N2CCOCC2)cc2[nH]c(-c3c(NCC(O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL2005886 pKi 3.981 nM
Cn1cc(Nc2ncc(Br)c(Nc3ccccc3C(N)=O)n2)cn1 CHEMBL1994669 pKi 3.981 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 3.981 nM
Cc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1Nc1ccc(OCC(N)=O)cc1 CHEMBL1988838 pKi 3.981 nM
CC1CCN(C(=O)CC#N)CC1N(C)c1ncnc2[nH]ccc12 CHEMBL234085 pKi 3.981 nM
C[C@H](Nc1ccnc(-n2cnc3ccncc32)n1)c1ccccc1 CHEMBL221029 IC50 4.0 nM
Cc1cc(Nc2nc(O[C@@H](C)c3ccc(F)cn3)c(C#N)nc2C)n[nH]1 CHEMBL570192 IC50 4.0 nM
CCN(CC(F)(F)F)C(=O)C1CCCN(c2cc(-c3c(N)nn4cccnc34)ncn2)C1 CHEMBL569092 IC50 4.0 nM
Oc1ccc(C2Nc3ccccc3-c3ccnc4[nH]cc2c34)c(Cl)c1 CHEMBL591800 Ki 4.0 nM
Cc1cnc(Nc2cncc(N[C@@H](C)c3ncc(F)cn3)n2)s1 CHEMBL1087898 IC50 4.0 nM
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL1079077 IC50 4.0 nM
O=c1[nH]ccc2nc(Nc3c(F)cc(F)cc3Cl)c3ccc(F)cc3c12 CHEMBL1290651 IC50 4.0 nM
COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Br)n[nH]1 CHEMBL1650728 IC50 4.0 nM
COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)nc(N3CCOCC3)c2F)n[nH]1 CHEMBL1650736 IC50 4.0 nM
COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)nc(N3CCOCC3)c2Cl)n[nH]1 CHEMBL1650737 IC50 4.0 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2C)n[nH]1 CHEMBL1650725 IC50 4.0 nM
NC(=O)c1cnc(NC(C2CC2)C2CC2)c2c1[nH]c1cc(-c3cnc(N)cn3)ccc12 CHEMBL1835148 IC50 4.0 nM
CNC(=O)c1cnc(N)c2cc(-c3ccc(C(C)(C)C#N)cc3)sc12 CHEMBL1938653 IC50 4.0 nM
Cc1cc(Nc2nc(O[C@@H](C)c3ncc(F)cc3F)c(F)c(N3CCOCC3)n2)n[nH]1 CHEMBL2381984 IC50 4.0 nM
Cc1cc(Nc2nc(O[C@@H](C)c3ccc(F)cn3)c(F)c(N3CCOCC3)n2)n[nH]1 CHEMBL2381982 IC50 4.0 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)c(F)c(N3CCNCC3)n2)n[nH]1 CHEMBL2381976 IC50 4.0 nM
N#CC1CCCC1Nc1ncnc2c(=O)[nH]ccc12 CHEMBL2436967 Ki 4.0 nM
Cc1csc2c(Nc3cn(C)cn3)nc(N[C@@H](C)c3ncc(F)cn3)nc12 CHEMBL3116056 IC50 4.0 nM
N#C[C@H]1CCC2(C[C@@H]1n1cc(C(N)=O)c(Nc3ccccc3)n1)OCCO2 CHEMBL3650681 IC50 4.0 nM
C[C@@]1(O)CC[C@H](n2cc(C(N)=O)c(Nc3ccc([C@](C)(O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647839 IC50 4.0 nM
[C-]#[N+][C@H]1C[C@@H](C(C)(C)O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647911 IC50 4.0 nM
C[C@@]1(O)CC[C@H](n2cc(C(N)=O)c(Nc3ccc([C@@](C)(O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647841 IC50 4.0 nM
N#C[C@H]1C[C@@H](NCC(F)F)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647738 IC50 4.0 nM
CS(=O)(=O)CCNC1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647725 IC50 4.0 nM
N#C[C@@H]1CCCC[C@H]1n1cc(C(N)=O)c(Nc2ccc3c(c2)CCS3(=O)=O)n1 CHEMBL3639467 IC50 4.0 nM
N#C[C@H]1C[C@@H](N2CCC23COC3)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647723 IC50 4.0 nM
N#C[C@@H]1CCCC[C@H]1n1cc(C(N)=O)c(Nc2ccc3c(c2)CN(CC(F)(F)F)C3=O)n1 CHEMBL3699522 IC50 4.0 nM
CC1(C)CN([C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc([C@@H](O)C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3703037 IC50 4.0 nM
CC1(c2ccc(Nc3nn([C@H]4CC[C@H](O)C[C@@H]4C#N)cc3C(N)=O)cc2)COC1 CHEMBL3647863 IC50 4.0 nM
N#C[C@H]1C[C@H](NC2COC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(CC(F)(F)F)cc2)n1 CHEMBL3703049 IC50 4.0 nM
N#C[C@H]1C[C@@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647741 IC50 4.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)NCc3ccccn3)cc2)n1 CHEMBL3702906 IC50 4.0 nM
CC1(c2ccc(Nc3nn([C@H]4CC[C@@H](O)C[C@@H]4C#N)cc3C(N)=O)cc2)COC1 CHEMBL3702954 IC50 4.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)NCc3ccc(Cl)cc3)cc2)n1 CHEMBL3702911 IC50 4.0 nM
C[C@](O)(c1ccc(Nc2nn([C@H]3CC[C@@H](O)C[C@@H]3C#N)cc2C(N)=O)cc1)C(F)(F)F CHEMBL3702944 IC50 4.0 nM
CC(C)(c1ccc(Nc2nn([C@H]3CC[C@@](C)(O)C[C@@H]3C#N)cc2C(N)=O)cc1)C(O)C(F)(F)F CHEMBL3647834 IC50 4.0 nM
CCS(=O)(=O)c1ccc(Nc2nn(C3CCCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3699511 IC50 4.0 nM
CC(C)(c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1F)[C@@H](O)C(F)(F)F CHEMBL3699534 IC50 4.0 nM
C[C@]1(O)CC[C@H](n2cc(C(N)=O)c(Nc3ccc([C@](C)(O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647838 IC50 4.0 nM
Cc1ccc(NC(=O)NC2CCCC2)cc1N1CCc2nc(Nc3ccc(OCCN4CCCC4)cc3)ncc2C1 CHEMBL3658112 IC50 4.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@@H](O)C(F)F)nc2)n1 CHEMBL3699539 IC50 4.0 nM
N[C@H]1CC[C@@H](Nc2cc[nH]c(=O)c2-c2nc3ccccc3[nH]2)CC1 CHEMBL3780091 IC50 4.0 nM
N#Cc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)s1 CHEMBL3937067 IC50 4.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2cncc(F)c2)CC1 CHEMBL3905278 IC50 4.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2cccc(F)n2)CC1 CHEMBL3933330 IC50 4.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cccnc3)n2)CC1 CHEMBL3922799 IC50 4.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)CCN(C(=O)OCC(F)(F)F)CC1 CHEMBL3942252 IC50 4.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3cccnc3)n2)CCN(C(=O)OCC(F)(F)F)CC1 CHEMBL3984895 IC50 4.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ccc(F)cc2)CC1 CHEMBL3906618 IC50 4.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ccc(Cl)cc2)CC1 CHEMBL3982398 IC50 4.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(Nc2cccc(Cl)c2)CC1 CHEMBL3893735 IC50 4.0 nM
N#C[C@@H]1CCOC[C@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)c(F)c2)n1 CHEMBL3913755 IC50 4.0 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)nc2)n1 CHEMBL4113945 IC50 4.0 nM
N#C[C@@H]1CCOC[C@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)nc2)n1 CHEMBL3938373 IC50 4.0 nM
CC(=O)N1CCC2(CCC(Nc3nc(Nc4cnn(C)c4)ncc3Cl)CC2)CC1 CHEMBL3905686 IC50 4.0 nM
N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCC(C(=O)NO)CC4)cc3)n2)cc1 CHEMBL4162254 IC50 4.0 nM
O=C(CCCCCn1cc(Nc2ncc(Cl)c(Nc3ccc(Cl)cc3)n2)cn1)NO CHEMBL4526274 IC50 4.0 nM
Cc1cncc(Nc2cc(NC3CCN(c4ccc(C#N)cn4)CC3)c(C(N)=O)cn2)n1 CHEMBL4470355 IC50 4.0 nM
Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2CCO)n1 CHEMBL4742670 Ki 4.0 nM
Cc1cnc(Nc2ccc(CNC(=O)C3CC3)cc2)nc1-c1cnn(C(C)C)c1 CHEMBL5408994 IC50 4.0 nM
N#CCC1CCN(c2nc(Nc3ccc(N4CCC(O)CC4)cc3)c3c(=O)[nH]ncc3n2)CC1 CHEMBL4594275 IC50 4.0 nM
COc1ccccc1Nc1cc(Nc2ccc(CC(=O)O[C@@H]3CCOC3)cn2)ncc1C(N)=O CHEMBL5407260 IC50 4.0 nM
NC(=O)c1nnc(-c2c(F)cccc2F)cc1Nc1ccc(N2CCOCC2)cn1 CHEMBL5420928 IC50 4.0 nM
Cc1ccc(-n2cc(-c3cccn4nc(Nc5ccc(C6CCNCC6)cc5)nc34)cn2)cc1 CHEMBL3645021 IC50 4.04 nM
CN(C)C[C@@H]1CCCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL3951860 Ki 4.07 nM
CCOC1CCCN(S(=O)(=O)CC2CCC(N(C)c3ncnc4[nH]ccc34)CC2)C1 CHEMBL3652277 IC50 4.09 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1-c1cc2c(o1)CCN(S(C)(=O)=O)C2 CHEMBL4521339 IC50 4.1 nM
N#Cc1ccc(N2CCC(Nc3cc(Nc4cnccn4)ncc3C(N)=O)CC2)nc1 CHEMBL4454640 IC50 4.1 nM
O=C(CCCCCn1cc(Nc2ncc3ccn(Cc4cccc(F)c4)c3n2)cn1)NO CHEMBL5092781 IC50 4.1 nM
CN(CC1(C#N)CCCCC1)C1CCN(c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3897943 Ki 4.15 nM
CC(=O)Nc1ccc(-c2ccnc(Nc3cccc(N4CCOCC4)c3)n2)cc1 CHEMBL2208025 IC50 4.2 nM
CC[C@@H](NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(Cl)ccc34)nc12)C(=O)N1CC(C#N)C1 CHEMBL2376153 IC50 4.2 nM
CCn1c(C(=O)N(C2CC2)C2CC2)cc2c3c(ncn3C)c(NC)nc21 CHEMBL3622130 IC50 4.2 nM
COc1ccc(C#N)cc1-c1nn(CC2(O)CCCC2)cc1NC(=O)c1cnn2cccnc12 CHEMBL3667524 Ki 4.2 nM
Cc1cc(NC(=O)c2cnn3ccc(N)nc23)n(-c2ccccc2C)n1 CHEMBL3670397 Ki 4.2 nM
CCc1cc(O)ccc1-c1ccc2c(C(N)=O)n[nH]c2c1 CHEMBL4096219 IC50 4.2 nM
Cc1cnc(Nc2cc(F)c(N3CCOCC3)c(F)c2)nc1-c1cc2c(o1)CCN(C(=O)CC#N)C2 CHEMBL4449906 IC50 4.2 nM
CN(C)C1CCN(C(=O)c2nc(-c3cc(Cl)ccc3OC(F)F)c(NC(=O)c3cnn4cccnc34)s2)CC1 CHEMBL3918206 Ki 4.29 nM
CN1CCN(c2ccc(-c3cnc4cccc(-c5cc(F)c(CN6CCOCC6)c(F)c5)c4n3)cc2)CC1 CHEMBL1089773 IC50 4.3 nM
COc1cccc(-c2cc(C(N)=O)c3[nH]c4cc(C(=O)N5CCN(C)CC5)ccc4c3c2)c1 CHEMBL3622198 IC50 4.3 nM
O=C(CCCCCOc1ccc2cc1COC/C=C/COCc1cccc(c1)-c1ccnc(n1)N2)NO CHEMBL3951291 IC50 4.3 nM
IC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3934116 IC50 4.3 nM
Cc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1-c1ccc(NC(=O)CCCCCCC(=O)NO)cc1 CHEMBL4289006 IC50 4.3 nM
O=c1[nH]cccc1Nc1ncc2[nH]c(=O)n([C@@H]3CC[C@@H](O)c4ccccc43)c2n1 CHEMBL4556988 IC50 4.3 nM
Cc1cnc(Nc2ccc(OCC(=O)NO)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL5408205 IC50 4.33 nM
CNC(=O)c1cnc2[nH]ccc2c1NC1CCCN(Cc2cccc(OC)c2)CC1 CHEMBL4787133 IC50 4.34 nM
c1ccc(CN2CCC(n3cnc4cnc5[nH]ccc5c43)CC2)cc1 CHEMBL2152305 Ki 4.4 nM
CC(=O)Nc1ccc(-c2nc(Nc3ccc(N4CCOCC4)cc3)ncc2F)cc1 CHEMBL2208027 IC50 4.4 nM
C[C@@H]1CCCC[C@@H]1n1c(=O)[nH]c2cnc3[nH]ccc3c21 CHEMBL3593579 IC50 4.4 nM
Fc1cc(Cl)ccc1CN1CCC(c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3949040 IC50 4.4 nM
Clc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)o1 CHEMBL3979988 IC50 4.4 nM
Cc1cc(Nc2cc(C)[nH]n2)nc(N2CCC3(CC2)OCCN([C@@H](C)c2ccc(-n4cc(F)cn4)nc2)C3=O)n1 CHEMBL4846521 IC50 4.4 nM
Cc1cc(Nc2ncc(C)c(N3CC(CC#N)(N4CCCCC4)C3)n2)sn1 CHEMBL5432029 IC50 4.4 nM
COc1ccc(-c2cccn3nc(Nc4ccc(C5CCN(CC(=O)N(C)C)CC5)cc4)nc23)c(F)c1 CHEMBL3645076 IC50 4.41 nM
O=C(Nc1cn(CC(=O)N2CCC(N(CCC(F)(F)F)Cc3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3900096 Ki 4.45 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(C#N)cc2)[C@H](C)C1 CHEMBL4744772 IC50 4.46 nM
Cc1ccc(C(=O)N2CCN(c3nc(Nc4cc(C)[nH]n4)c4cccn4n3)CC2)cc1 CHEMBL1682374 IC50 4.5 nM
CNc1nc2c(cc(C(=O)N(C3CC3)C3CC3)n2CCCO)c2c1ncn2C CHEMBL3622128 IC50 4.5 nM
C[C@@H]1CCN(c2ccc(C#N)cn2)C[C@@H]1n1c(=O)[nH]c2cnc3[nH]ccc3c21 CHEMBL5278895 IC50 4.5 nM
CCN(CCC(F)(F)F)C(=O)C1CCCN(c2cc(-c3c(N)nn4cccnc34)ncn2)C1 CHEMBL570456 IC50 4.6 nM
Cc1cc(Nc2nc(N3CCN(C(=O)Cc4ccccc4F)CC3)nn3cccc23)n[nH]1 CHEMBL1682383 IC50 4.6 nM
Brc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)s1 CHEMBL3967749 IC50 4.6 nM
N#CCC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3944859 IC50 4.6 nM
O=C1NCN([C@H]2CC[C@H](CNCC(F)(F)F)CC2)c2c1cnc1[nH]ccc21 CHEMBL3986613 IC50 4.6 nM
CN(CC(F)(F)F)C[C@H]1CC[C@H](N2CNC(=O)c3cnc4[nH]ccc4c32)CC1 CHEMBL3930342 IC50 4.6 nM
CN1CCN(c2ccc(Nc3nccc(-c4ccc(NC(=O)CCCCCCC(=O)NO)cc4)n3)cc2)CC1 CHEMBL4292408 IC50 4.6 nM
O[C@]12C[C@@H]3C[C@H](C1)[C@@H](Nc1c(-c4cn[nH]c4)cnc4[nH]ccc14)[C@@H](C3)C2 CHEMBL5421116 IC50 4.634 nM
CN(C)C[C@H]1CCCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1 CHEMBL4115152 Ki 4.66 nM
CCCN(CCC)C(=O)C1CCCN(c2cc(-c3c(N)nn4cccnc34)ncn2)C1 CHEMBL569091 IC50 4.7 nM
O=C(CCCOc1ccc2cc1COC/C=C/COCc1cccc(c1)-c1ccnc(n1)N2)NO CHEMBL3942555 IC50 4.7 nM
N#CCC(=O)N1CCCC12CCCN(c1ncnc3[nH]ccc13)C2 CHEMBL3689519 IC50 4.7 nM
COc1ccc(Cl)cc1-c1nn(C)cc1NC(=O)c1cncc2cn(C)nc12 CHEMBL4781423 Ki 4.7 nM
Cc1cc(Nc2nc(N3CCN(C(=O)c4ccc(C#N)cc4)CC3)nn3cccc23)n[nH]1 CHEMBL1682376 IC50 4.8 nM
CCn1cc(-c2cccc3nc(Nc4ccnc(C)c4)nn23)cn1 CHEMBL2414556 Ki 4.8 nM
CC1(C)CC(n2c(=O)[nH]c3cnc(-c4cnc5ccc(F)cn45)nc32)CCO1 CHEMBL4574559 IC50 4.8 nM
C[C@H](c1ccc(F)cn1)n1c(=O)[nH]c2cnc(Nc3cc(F)c[nH]c3=O)nc21 CHEMBL4517586 IC50 4.8 nM
Cc1cc(NC(=O)c2cnn3cccnc23)n(-c2cc(Cl)ccc2C)n1 CHEMBL3667508 Ki 4.9 nM
CS(=O)(=O)c1cccc(-c2cccc3nc(Nc4ccc(CN5CCOCC5)cc4)nn23)c1 CHEMBL3642316 IC50 4.9 nM
Ic1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)o1 CHEMBL3923513 IC50 4.9 nM
CS(=O)(=O)NC[C@H]1CC[C@H](N2CN(C3CC3)C(=O)c3cnc4[nH]ccc4c32)CC1 CHEMBL3975691 IC50 4.9 nM
N#Cc1ccc(N2CCC(Nc3cc(Nc4ccccn4)ncc3C(N)=O)CC2)nc1 CHEMBL4455068 IC50 4.9 nM
Cc1c[nH]c2ncc3ccn([C@H]4CN(C(=O)CC#N)CC[C@H]4C)c3c12 CHEMBL5271864 IC50 4.9 nM
CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4cccc(N5CCN(CCCF)CC5)c4)nc23)cc1 CHEMBL3642408 IC50 4.93 nM
CN(C)C(=O)CN1CCC(c2ccc(Nc3nc4c(-c5cccc(N(C)C)c5)cccn4n3)cc2)CC1 CHEMBL3645078 IC50 4.99 nM
NC(=O)Nc1sc(-c2ccc(F)cc2)cc1C(N)=O CHEMBL257167 Ki 5.0 nM
Cc1cc(Nc2cnc(C#N)c(NC(C)c3ccc(F)cn3)n2)n[nH]1 CHEMBL568788 IC50 5.0 nM
COc1cc(Nc2nc3cccc(-c4ccc(NS(C)(=O)=O)cc4)c3o2)cc(OC)c1OC CHEMBL1081977 IC50 5.0 nM
Cc1cc(Nc2nc3cccc(-c4cc(F)c(CN5CCOCC5)c(F)c4)c3o2)ccc1C(=O)N(C)C CHEMBL1080159 IC50 5.0 nM
CNC(=O)c1ccc(Nc2nc3cccc(-c4cc(F)c(CN5CCOCC5)c(F)c4)c3o2)cc1C CHEMBL1082022 IC50 5.0 nM
Cc1cc(Nc2nc3cccc(-c4cc(F)c(CN5CCOCC5)c(F)c4)c3o2)ccc1C(=O)NCCCN(C)C CHEMBL1076700 IC50 5.0 nM
Cc1cnc(Nc2cc(N3CCOCC3)nc(N[C@@H](C)c3ccc(F)cn3)n2)s1 CHEMBL1087269 IC50 5.0 nM
N#Cc1ccc2ncn(-c3ncc4[nH]c(=O)n([C@@H]5CCOc6c(F)cccc65)c4n3)c2c1 CHEMBL1079594 IC50 5.0 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2F)n[nH]1 CHEMBL1650697 IC50 5.0 nM
Cn1cc(-c2ccc3c(c2)[nH]c2c(C(N)=O)ccc(NC4CCCCC4)c23)cn1 CHEMBL1835035 IC50 5.0 nM
C[C@H](Nc1ccc(C(N)=O)c2[nH]c3cc(-c4cnn(C)c4)ccc3c12)C(C)(C)C CHEMBL1835039 IC50 5.0 nM
CC(C)(C)NS(=O)(=O)c1ccc(-c2cc3c(N)ncc(C(=O)NCCN4CCCCC4)c3s2)cc1 CHEMBL1938658 IC50 5.0 nM
CC(C)(C)NS(=O)(=O)c1ccc(-c2cc3c(N)ncc(C(=O)NCCCN4CCOCC4)c3s2)cc1 CHEMBL1938660 IC50 5.0 nM
Cc1nc2cnc3[nH]ccc3c2n1C1CCCCC1 CHEMBL2159198 Ki 5.0 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)cc(N3CCOCC3)n2)n[nH]1 CHEMBL2381985 IC50 5.0 nM
COc1ccc(-c2cccc3nc(Nc4ccnc(C)c4)nn23)cc1 CHEMBL2414553 Ki 5.0 nM
NC(=O)c1cnc2[nH]ccc2c1N[C@@H]1[C@@H]2CC3C[C@H]1C[C@@](O)(C3)C2 CHEMBL3137308 IC50 5.0 nM
CNC1CCC(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3702973 IC50 5.0 nM
COC1CN(C2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(S(=O)(=O)C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3647724 IC50 5.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1N1CCc2nc(Nc3ccc(C(=O)NC4CCN(C)CC4)nc3)ncc2C1 CHEMBL3658111 IC50 5.0 nM
CS(=O)(=O)N[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3647915 IC50 5.0 nM
N#C[C@H]1C[C@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3699541 IC50 5.0 nM
N#C[C@H]1C[C@@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(OC(F)(F)F)cc2)n1 CHEMBL3647848 IC50 5.0 nM
N#C[C@H]1C[C@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647742 IC50 5.0 nM
Cc1ccc(NC(=O)c2cc(C(F)(F)F)ccn2)cc1N1CCc2nc(Nc3ccc(N4CCN(C)CC4)cc3)ncc2C1 CHEMBL3658109 IC50 5.0 nM
Clc1cnc2nc1NCc1cc(Br)cc(c1)OCCCc1cccc(c1)N2 CHEMBL3694592 IC50 5.0 nM
N#C[C@H]1CCCCC1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)F)cc2)n1 CHEMBL3699510 IC50 5.0 nM
N#C[C@H]1CCCCC1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)CC(F)(F)F)cc2)n1 CHEMBL3699513 IC50 5.0 nM
N#C[C@H]1C[C@@H](NCC(F)F)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)F)cc2)n1 CHEMBL3703093 IC50 5.0 nM
CC1(C)CN([C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc([C@H](O)C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3703064 IC50 5.0 nM
CN(C)[C@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3702970 IC50 5.0 nM
C[C@@](O)(c1ccc(Nc2nn([C@H]3CC[C@H](N4CCC4)C[C@@H]3C#N)cc2C(N)=O)cc1)C(F)(F)F CHEMBL3703027 IC50 5.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(OC(F)F)cc2)n1 CHEMBL3702924 IC50 5.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)c(CO)c2)n1 CHEMBL3699518 IC50 5.0 nM
N#C[C@@H]1C[C@@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647932 IC50 5.0 nM
CS(=O)(=O)c1ccc(Nc2nn([C@H]3CC[C@H](N4CC5(CCC5)C4)C[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3703096 IC50 5.0 nM
O=c1[nH]ccc(NC2CCOCC2)c1-c1nc2ccccc2[nH]1 CHEMBL3781427 IC50 5.0 nM
O=C(CCCCCCCOc1ccc2cc1COC/C=C/COCc1cccc(c1)-c1ccnc(n1)N2)NO CHEMBL3945293 IC50 5.0 nM
CC(C)(C)OC(=O)N1CC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(=O)N4CCS(=O)(=O)CC4)cc3)n2)C1 CHEMBL4109520 IC50 5.0 nM
COc1cc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)ccn1 CHEMBL3890522 IC50 5.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1 CHEMBL3938017 IC50 5.0 nM
Cc1noc(-c2ccc(Nc3nn(C4(CC#N)CCN(C(=O)OC(C)(C)C)CC4)cc3C(N)=O)cc2)n1 CHEMBL3984315 IC50 5.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2cccnc2)CC1 CHEMBL3949845 IC50 5.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2cncc(F)c2)CC1 CHEMBL3979997 IC50 5.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2ccncn2)CC1 CHEMBL3889909 IC50 5.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)OC(CF)CF)CC1 CHEMBL3902263 IC50 5.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(C(=O)OCC(F)F)CC1 CHEMBL3946128 IC50 5.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)CC(F)(F)F)CC1 CHEMBL3938808 IC50 5.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CCC(NC2CCOCC2)CC1 CHEMBL3911515 IC50 5.0 nM
COC1CN(C2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccnc(F)c4)n3)CC2)C1 CHEMBL3923034 IC50 5.0 nM
CC(F)(F)C(=O)N1CC[C@](CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)nc3)n2)[C@H](F)C1 CHEMBL4108087 IC50 5.0 nM
N#C[C@@H]1CCOC[C@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)c(Cl)c2)n1 CHEMBL3923812 IC50 5.0 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2cnc3cc(Cl)ccc3c2)n1 CHEMBL4109202 IC50 5.0 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(F)nc2)n1 CHEMBL4110738 IC50 5.0 nM
Cn1cc(Nc2ncc(Cl)c(NC3CCC4(CC3)CCN(C(=O)CC#N)C4)n2)cn1 CHEMBL3944322 IC50 5.0 nM
Cn1cc(Nc2ncc(Cl)c(NC3CCC4(CC3)CCN(S(C)(=O)=O)CC4)n2)cn1 CHEMBL3929488 IC50 5.0 nM
Cn1cc(Nc2ncc(Cl)c(NC3CCC4(CC3)CCN(C(=O)C(F)(F)F)CC4)n2)cn1 CHEMBL3953702 IC50 5.0 nM
N#Cc1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)cc1C#N CHEMBL4064171 IC50 5.0 nM
COC12CC3CC(C1)C(Nc1c(C(N)=O)cnc4[nH]ccc14)C(C3)C2 CHEMBL4246788 IC50 5.0 nM
NC(=O)c1cnc2[nH]ccc2c1NC1C2CC3CC1CC(O)(C3)C2 CHEMBL4242999 IC50 5.0 nM
NC(=O)c1cnc2[nH]ccc2c1NC1C2CC3CC1CC(C2)C3O CHEMBL4446102 IC50 5.0 nM
O=C(CCCCCCn1cc(Nc2ncc(Cl)c(NC3CC3)n2)cn1)NO CHEMBL4466059 IC50 5.0 nM
O=C(CCCCCn1cc(Nc2ncc(Cl)c(Nc3ccc(F)cc3)n2)cn1)NO CHEMBL4564021 IC50 5.0 nM
N#CC[C@@H](C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL1287854 IC50 5.0 nM
CC(=O)N1C2CC1CN(C1CCN(c3ccc(Nc4nccc(-c5ccc(C(=O)NCC#N)cc5)n4)cc3)CC1)C2 CHEMBL5171759 IC50 5.0 nM
N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCC(N5CC6OCCOC6C5)CC4)cc3)n2)cc1 CHEMBL5192167 IC50 5.0 nM
N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCC(N5CCC6(CCCO6)CC5)CC4)cc3)n2)cc1 CHEMBL5169511 IC50 5.0 nM
N#CCNC(=O)c1ccc(-c2nc(Nc3ccc(N4CCC(N5CCOCC5)CC4)cc3)ncc2F)cc1 CHEMBL5180789 IC50 5.0 nM
C=CS(=O)(=O)NCc1ccc(Nc2ncc(C)c(-c3cnn(C(C)C)c3)n2)cc1 CHEMBL5422938 IC50 5.0 nM
Cc1cnc(Nc2ccc(CNS(=O)(=O)C3CC3)cc2)nc1-c1cnn(C(C)C)c1 CHEMBL5419978 IC50 5.0 nM
NC(=O)c1cnc2[nH]ccc2c1NC1[C@@H]2CC3C[C@H]1CC(O)(C3)C2 CHEMBL5424861 IC50 5.0 nM
COC[C@@H](C)OC(=O)Cc1ccc(Nc2cc(Nc3ccccc3OC)c(C(N)=O)cn2)nc1 CHEMBL5404574 IC50 5.0 nM
COc1ccccc1Nc1cc(Nc2ccc(CC(=O)O[C@H]3CCOC3)cn2)ncc1C(N)=O CHEMBL5396554 IC50 5.0 nM
NC(=O)c1nnc(-c2c(F)cccc2F)cc1Nc1ccc(N2CCOCC2=O)cn1 CHEMBL5413489 IC50 5.0 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(Cc4ccccc4)c3n2)c1 CHEMBL1993424 pKi 5.012 nM
O=C1Nc2cc(-c3ccc(O)cc3)ccc2C1=Cc1ccc[nH]1 CHEMBL1980329 pKi 5.012 nM
O=c1[nH]c2cnc(-n3cnc4ccc(F)cc43)nc2n1C1CCOc2c(F)cccc21 CHEMBL2000393 pKi 5.012 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 5.012 nM
CCc1cc(O)c(F)cc1-c1cc(NS(=O)(=O)CC)c2cn[nH]c2c1 CHEMBL4483364 pIC50 5.012 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@H](C)CO)c2nc(N)ncc2c1 CHEMBL5074310 pIC50 5.012 nM
COc1cc(-c2cnc3cccc(-c4ccc(CC(=O)N5CCS(=O)(=O)CC5)cc4)c3n2)cc(OC)c1OC CHEMBL1093468 IC50 5.1 nM
CNc1ccn2ncc(C(=O)Nc3cc(C)nn3-c3cccc(Cl)c3)c2n1 CHEMBL2178247 Ki 5.1 nM
CC(=O)Nc1ccc(-c2nc(Nc3ccc(N4CCOCC4)cc3)ncc2C)cc1 CHEMBL2208028 IC50 5.1 nM
COCC(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL3645119 Kd 5.1 nM
Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2c(Cl)cccc2Cl)n1 CHEMBL2177122 Ki 5.2 nM
CN1CCC[C@@H]1C(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL2207759 IC50 5.2 nM
CN1CCN(c2ccc3c(c2)[nH]c2c(C(N)=O)cc(-c4ccc(CN5CCOCC5)c(Cl)c4)cc23)CC1 CHEMBL3589327 IC50 5.2 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)c3cnc(N5CCCCC5)cn3)C4)n[nH]c2c1 CHEMBL3644620 fIC50 5.2 nM
Cc1cc(Nc2nc(N3CCN(C(=O)Cc4ccccc4C)CC3)nn3cccc23)n[nH]1 CHEMBL1682381 IC50 5.3 nM
Cc1ccc(NC(=O)c2cc(C(F)(F)F)ccn2)cc1N1CCc2nc(Nc3ccc(C(=O)N4CCN(C)CC4)cc3)ncc2C1 CHEMBL3658119 IC50 5.3 nM
C[C@H](c1ccc(F)cn1)n1c(=O)[nH]c2cnc(Nc3ccc[nH]c3=O)nc21 CHEMBL4458055 IC50 5.3 nM
Cc1cnc(Nc2cc(NC3CCN(c4ccc(C#N)cn4)CC3)c(C(N)=O)cn2)cn1 CHEMBL4471707 IC50 5.3 nM
Cc1cnc(Nc2ccc(OCCCCCCC(=O)NO)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL5433552 IC50 5.32 nM
CS(=O)(=O)C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3934580 IC50 5.4 nM
COc1cc(O)ccc1-c1ccc2c(-c3nc4ccccc4[nH]3)n[nH]c2c1 CHEMBL3914503 IC50 5.4 nM
OC1CCN(c2cc(Nc3nccc4nc(-c5c(Cl)cccc5Cl)[nH]c34)ncn2)CC1 CHEMBL4070262 Ki 5.4 nM
O=c1[nH]c2cnc(-c3cnc4ccc(F)cn34)nc2n1[C@H]1CC[C@H](O)CC1 CHEMBL4467200 IC50 5.4 nM
Cc1cc(Nc2ncc(C)c(N3CC4CCCC(C3)N4CC#N)n2)sn1 CHEMBL5410239 IC50 5.4 nM
CN1CCN(c2ccc3c(c2)[nH]c2c(C(N)=O)cc(-c4ccc5c(cnn5C)c4)cc23)CC1 CHEMBL3589329 IC50 5.5 nM
COc1ccc(-c2cc(C(N)=O)c3[nH]c4cc(C(=O)N5CCOCC5)ccc4c3c2)cc1F CHEMBL3589176 IC50 5.5 nM
COc1ccc(-c2cc(C(N)=O)c3[nH]c4cc(C(=O)N5CCN(C)CC5)ccc4c3c2)cc1 CHEMBL3622199 IC50 5.5 nM
c1cc(-c2ccncc2)c2nc(Nc3ccc(N4CCOCC4)cc3)nn2c1 CHEMBL3642257 IC50 5.5 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CN(S(=O)(=O)c2cccc([N+](=O)[O-])c2)CC12CC2 CHEMBL4279526 IC50 5.5 nM
N#Cc1ccc(N2CCC(Nc3cc(Nc4ccncn4)ncc3C(N)=O)CC2)nc1 CHEMBL4463043 IC50 5.5 nM
C[C@@H](Nc1ccc2[nH]nc(/C=C/c3ccccn3)c2c1)c1cc(F)cc(F)c1 CHEMBL4792981 Kd 5.5 nM
CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4cccc(S(C)(=O)=O)c4)nc23)cc1 CHEMBL2062800 IC50 5.57 nM
O=C(Nc1cn(CCO)nc1-c1cccc(Cl)c1)c1cnn2cccnc12 CHEMBL2178260 Ki 5.6 nM
CS(=O)(=O)c1cccc(-c2cccn3nc(Nc4cccc(N5CCOCC5)c4)nc23)c1 CHEMBL3642270 IC50 5.6 nM
FC(F)(F)c1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)o1 CHEMBL3909146 IC50 5.6 nM
N#CCN(C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1)C(=O)CC(F)(F)F CHEMBL3952261 IC50 5.6 nM
CCc1cc(O)ccc1-c1ccc2c(-c3nc4c([nH]3)CN(S(C)(=O)=O)CC4)n[nH]c2c1 CHEMBL4069951 IC50 5.6 nM
N#CC[C@H]1CC[C@H](n2c(CC(=O)NCC(F)(F)F)nc3cnc4[nH]ccc4c32)CC1 CHEMBL4439418 IC50 5.6 nM
CC(C)(C#N)CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 CHEMBL4537718 IC50 5.6 nM
CN1CCN(c2cccc(Nc3nc4c(-c5cnn(-c6ccc(F)cc6)c5)cccn4n3)c2)CC1 CHEMBL3645020 IC50 5.64 nM
O=C(Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1)[C@H]1CCNC1 CHEMBL2207758 IC50 5.7 nM
COc1cccc(-c2cc(C(N)=O)c3[nH]c4cc(C(=O)N5CCOCC5)ccc4c3c2)c1 CHEMBL3589175 IC50 5.7 nM
Cc1cc(NC(=O)c2cnn3cccnc23)n(-c2cc(C#N)ccc2C)n1 CHEMBL3667509 Ki 5.7 nM
COc1ccc(Cl)cc1-c1nn(CC(O)(C(F)(F)F)C(F)(F)F)cc1NC(=O)c1cnn2cccnc12 CHEMBL3639663 Ki 5.7 nM
N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3c2CCN3)cn1 CHEMBL4637163 IC50 5.7 nM
C#CCC1(n2cc(-c3ncnc4[nH]ccc34)cn2)CN(S(=O)(=O)CC)C1 CHEMBL5427854 IC50 5.7 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@H](c3ncccn3)C2)CC1 CHEMBL3652358 IC50 5.72 nM
COc1ncc(Cl)cc1-c1nn(CC(=O)N(C)C)cc1NC(=O)c1cnn2cccnc12 CHEMBL3667529 Ki 5.8 nM
O=C1c2cnc3[nH]ccc3c2N([C@H]2CC[C@H](CNCC(F)(F)F)CC2)CN1CC1CCCO1 CHEMBL3916308 IC50 5.8 nM
CCC(=O)N1CCc2oc(-c3nc(Nc4ccc(N5CCOCC5)cc4)ncc3C)cc2C1 CHEMBL4464597 IC50 5.8 nM
N#Cc1ccc(-c2cccn3nc(Nc4ccc(C5CCNCC5)cc4)nc23)cc1 CHEMBL3645071 IC50 5.81 nM
COc1cc(Nc2ncc3ccn(-c4ccccn4)c3n2)cc(OC)c1OC CHEMBL205098 IC50 5.9 nM
C[C@@H](NC(=O)c1c[nH]c2ncc(-c3ncn4cc(F)ccc34)nc12)C(=O)N1CC(C#N)C1 CHEMBL2376157 IC50 5.9 nM
CN1CCN(c2cccc(Nc3nc4c(-c5cccc(CN(C)S(C)(=O)=O)c5)cccn4n3)c2)CC1 CHEMBL3642397 IC50 5.94 nM
CONC(=O)c1cc2c(N[C@@H](C)c3ccccc3)nc(-n3cnc4ccncc43)nc2n1C CHEMBL391492 IC50 6.0 nM
Cc1cc(Nc2cnc(C#N)c(N[C@@H](C)c3ncc(F)cn3)n2)n[nH]1 CHEMBL570002 IC50 6.0 nM
Nc1nn2cccnc2c1-c1cc(NCc2ccccc2)ncn1 CHEMBL570890 IC50 6.0 nM
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3cccc(CN4CCCC4)c3)n2)cc1 CHEMBL1078275 IC50 6.0 nM
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCC(O)CC4)cc3)n2)cc1 CHEMBL1079078 IC50 6.0 nM
Cc1cc(Nc2nc(N3CCN(C(=O)c4ccccc4C#N)CC3)nn3cccc23)n[nH]1 CHEMBL1682375 IC50 6.0 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)c(Cl)c(N3CCOCC3)n2)n[nH]1 CHEMBL2380329 IC50 6.0 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)c(F)c(N3CCOCC3)n2)n[nH]1 CHEMBL2381981 IC50 6.0 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(NC[C@H]4CCCO4)n3)cc2)CC1 CHEMBL3426891 IC50 6.0 nM
N#C[C@H]1CC(NCC(F)F)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)F)cc2)n1 CHEMBL3703089 IC50 6.0 nM
C=C[C@@]1(O)CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3647846 IC50 6.0 nM
N#C[C@H]1C[C@@H](N2CCOCC2)CCC1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3702978 IC50 6.0 nM
CC(C)(CF)c1ccc(Nc2nn([C@H]3CC[C@H](O)C[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3647865 IC50 6.0 nM
CC1(C)CN([C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc([C@](C)(O)C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3703060 IC50 6.0 nM
N#C[C@H]1C[C@H](N2CC(F)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3703080 IC50 6.0 nM
N#C[C@H]1C[C@@H](NCC(F)(F)F)CCC1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3702976 IC50 6.0 nM
N#C[C@H]1C[C@@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1 CHEMBL3647849 IC50 6.0 nM
CN(CC(F)(F)F)[C@H]1CCC(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)[C@@H](C#N)C1 CHEMBL3647806 IC50 6.0 nM
CN1CCN(c2ccc(Nc3ncc4c(n3)CCN(c3cc(NC(=O)c5cccc(C(F)(F)F)c5)ccc3Cl)C4=O)cc2)CC1 CHEMBL3658115 IC50 6.0 nM
CN([C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1)S(C)(=O)=O CHEMBL3647917 IC50 6.0 nM
CC(C)(CF)c1ccc(Nc2nn([C@H]3CC[C@@H](O)C[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3702945 IC50 6.0 nM
N#C[C@H]1CCCCC1n1cc(C(N)=O)c(Nc2ccc3c(c2)CCS3(=O)=O)n1 CHEMBL3702930 IC50 6.0 nM
Cn1c(C(=O)NCCCN2CCOCC2)cc2c(-c3ccc(NC(=O)C(C)(C)C)cc3)ncnc21 CHEMBL3798482 IC50 6.0 nM
Cc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1995703 IC50 6.0 nM
NC(=O)c1cc(-c2ccc(Cl)c(Cl)c2)cc2c1[nH]c1ccc(C(=O)NCCn3ccnc3)cc12 CHEMBL3646813 IC50 6.0 nM
NC(=O)c1cc(-c2ccc(Cl)c(Cl)c2)cc2c1[nH]c1ccc(C(=O)N[C@@H]3CCNC3)cc12 CHEMBL3646814 IC50 6.0 nM
NC(=O)c1cc(-c2ccc(Cl)c(Cl)c2)cc2c1[nH]c1ccc(C(=O)NCCN3CCOCC3)cc12 CHEMBL3646815 IC50 6.0 nM
CN(C)CCNC(=O)c1ccc2[nH]c3c(C(N)=O)cc(-c4ccc(Cl)c(Cl)c4)cc3c2c1 CHEMBL3646816 IC50 6.0 nM
CN1CCN(C(=O)c2ccc3c(c2)[nH]c2c(C(N)=O)cc(-c4ccc(Cl)c(Cl)c4)cc23)CC1 CHEMBL3622200 IC50 6.0 nM
COc1ccc(-c2cc(C(N)=O)c3[nH]c4cc(C(=O)N5CCN(C)CC5)ccc4c3c2)cc1F CHEMBL3646819 IC50 6.0 nM
CN1CCN(C(=O)c2ccc3c(c2)[nH]c2c(C(N)=O)cc(-c4ccccc4)cc23)CC1 CHEMBL3646820 IC50 6.0 nM
COc1cccc(-c2cc(C(N)=O)c3[nH]c4cc(C(=O)N5CCN(Cc6cccnc6)CC5)ccc4c3c2)c1 CHEMBL3646821 IC50 6.0 nM
COc1cccc(-c2cc(C(N)=O)c3[nH]c4cc(C(=O)NCCN(C)C)ccc4c3c2)c1 CHEMBL3646823 IC50 6.0 nM
COc1cccc(-c2cc(C(N)=O)c3[nH]c4cc(C(=O)C5O[C@H]6CN[C@H]5C6)ccc4c3c2)c1 CHEMBL3646826 IC50 6.0 nM
NC(=O)c1cc(-c2ccc(OC(F)(F)F)cc2)cc2c1[nH]c1cc(C(=O)N3CCOCC3)ccc12 CHEMBL3646835 IC50 6.0 nM
COc1ccc(-c2cc(C(N)=O)c3[nH]c4ccc(C(=O)N5CCOCC5)cc4c3c2)cc1OC CHEMBL3646836 IC50 6.0 nM
Cc1ccc(-c2cc(C(N)=O)c3[nH]c4cc(N5CCC(F)(F)C5)ccc4c3n2)cn1 CHEMBL3649608 IC50 6.0 nM
NC(=O)c1cc(-c2cccc(C(F)(F)F)c2)nc2c1[nH]c1cc(N3CCNCC3)ccc12 CHEMBL3649610 IC50 6.0 nM
COCCOc1ccc(-c2cc(C(N)=O)c3[nH]c4cc(N5CCOCC5)ccc4c3n2)cc1Cl CHEMBL3649618 IC50 6.0 nM
NC(=O)c1cc(-c2ccc(OCCN3CCCOCC3)c(Cl)c2)nc2c1[nH]c1cc(N3CCOCC3)ccc12 CHEMBL3649620 IC50 6.0 nM
COCCN1CCN(Cc2ccc(-c3cc(C(N)=O)c4[nH]c5cc(N6CCOCC6)ccc5c4n3)s2)CC1 CHEMBL3649621 IC50 6.0 nM
NC(=O)c1cc(-c2cc(CN3CCOCC3)co2)nc2c1[nH]c1cc(N3CCOCC3)ccc12 CHEMBL3649622 IC50 6.0 nM
CN1CCN(c2ccc(-c3cc(C(N)=O)c4[nH]c5cc(C(=O)N6CCOCC6)ccc5c4n3)cc2)CC1 CHEMBL3649637 IC50 6.0 nM
Cc1ccc(-c2cc(C(N)=O)c3[nH]c4cc(N5CCOCC5)ccc4c3c2)cn1 CHEMBL3589328 IC50 6.0 nM
NC(=O)c1cc(-c2ccc(CO)nc2)nc2c1[nH]c1cc(N3CCOCC3)ccc12 CHEMBL3649644 IC50 6.0 nM
NC(=O)c1cc(-c2ccc3scnc3c2)cc2c1[nH]c1cc(C(=O)N3CCOCC3)ccc12 CHEMBL3649654 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2cccnc2)CC1 CHEMBL3899162 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(c2cc(F)ccn2)CC1 CHEMBL3949065 IC50 6.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C#N)cc3)n2)CC1 CHEMBL3976977 IC50 6.0 nM
CC(O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1 CHEMBL3960876 IC50 6.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C#N)nc3)n2)CC1 CHEMBL3896338 IC50 6.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(C#N)c3)n2)CC1 CHEMBL3938455 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(Cc2cccc(O)c2)CC1 CHEMBL3944536 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ccccc2)CC1 CHEMBL3930900 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2cccnc2F)CC1 CHEMBL3944488 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ccc(O)cc2)CC1 CHEMBL3927787 IC50 6.0 nM
COCCOC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)CC1 CHEMBL3948300 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(S(=O)(=O)C(F)(F)F)CC1 CHEMBL3901595 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)Nc2ccc(C#N)cc2)CC1 CHEMBL3916587 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CCC(Nc2cccnc2)CC1 CHEMBL3946481 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CCC(Nc2ccccc2O)CC1 CHEMBL3935010 IC50 6.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(Nc2cc(F)ccc2F)CC1 CHEMBL3926188 IC50 6.0 nM
N#C[C@@H]1CCN(Cc2cncs2)C[C@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3912265 IC50 6.0 nM
C[C@]1(C#N)CS(=O)(=O)CC1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3972345 IC50 6.0 nM
Cn1cc(Nc2ncc(Cl)c(NC3CCC4CN(C(=O)CC#N)CC4C3)n2)cn1 CHEMBL3890379 IC50 6.0 nM
Cn1cc(Nc2ncc(Cl)c(NC3CCC4(CC3)CCN(C(=O)CC#N)CC4)n2)cn1 CHEMBL3939630 IC50 6.0 nM
CN1CN([C@H]2CC[C@H](CNC3(C(F)(F)F)CC3)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3903817 IC50 6.0 nM
COc1cc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)cc(F)n1 CHEMBL4066193 IC50 6.0 nM
CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL4116008 IC50 6.0 nM
CC(Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1cc(F)ccc1Cl CHEMBL4541291 IC50 6.0 nM
CC(=O)N1CCc2cc(Nc3ncc(C)c(-c4cnn(C(C)C)c4)n3)ccc21 CHEMBL4869302 IC50 6.0 nM
COc1cc(Nc2ncc(C)c(N3CCC4(CCNC4=O)CC3)n2)cc(OC)c1OC CHEMBL5078528 IC50 6.0 nM
N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCC(N5CCC6(CCC(=O)O6)CC5)CC4)cc3)n2)cc1 CHEMBL5186530 IC50 6.0 nM
CCS(=O)(=O)NCc1ccc(Nc2ncc(C)c(-c3cnn(C(C)C)c3)n2)cc1 CHEMBL5424098 IC50 6.0 nM
Cc1cnc(Nc2ccccc2)nc1-c1cnn(CCC#N)c1 CHEMBL5440510 IC50 6.0 nM
COCCOC(=O)Cc1ccc(Nc2cc(Nc3ccccc3OC)c(C(N)=O)cn2)nc1 CHEMBL5422886 IC50 6.0 nM
Brc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)cc1 CHEMBL3927649 IC50 6.1 nM
O=S(=O)(C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1)C(F)(F)F CHEMBL3968041 IC50 6.1 nM
N#CCNS(=O)(=O)C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3896324 IC50 6.1 nM
N#CC[C@H]1CC[C@H](n2c(CC(=O)N3CCC(N4CCOCC4)CC3)nc3cnc4[nH]ccc4c32)CC1 CHEMBL4456630 IC50 6.1 nM
COc1ccc(F)cc1-c1nn(CC2(O)CCOCC2)cc1NC(=O)c1cnn2cccnc12 CHEMBL3667525 Ki 6.2 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@H](c3ccccn3)C2)CC1 CHEMBL3652378 IC50 6.22 nM
NC(=O)CN1CCC(c2ccc(Nc3ncc4ccc(-c5cccc6cccnc56)n4n3)cc2)CC1 CHEMBL1934351 IC50 6.3 nM
Cn1cc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cn1 CHEMBL1984548 pKi 6.31 nM
CCc1cc(O)c(F)cc1-c1cc(NS(=O)(=O)N(C)C)c2cn[nH]c2c1 CHEMBL4534573 pIC50 6.31 nM
CCc1cc(O)c(F)cc1-c1cc(NCCO)c2nc(N)ncc2c1 CHEMBL5082928 pIC50 6.31 nM
CCc1cc(O)c(F)cc1-c1cc(NC2CCN(C)CC2)c2nc(N)ncc2c1 CHEMBL5077126 pIC50 6.31 nM
Cc1nc2cnc3[nH]ccc3c2n1[C@@H]1CCNC[C@H]1F CHEMBL2159202 Ki 6.4 nM
CNC(=O)c1ccc(Nc2ncc3c(n2)CCN(c2cc(NC(=O)c4cc(C(F)(F)F)ccn4)ccc2Cl)C3)cc1 CHEMBL3658126 IC50 6.4 nM
CN1CCN(c2cccc(Nc3nc4c(-c5cccc(S(C)(=O)=O)c5)cccn4n3)c2)CC1 CHEMBL3642294 IC50 6.4 nM
N#Cc1ccc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)c(F)c1 CHEMBL3899634 IC50 6.4 nM
O=C1NCN([C@H]2CC[C@H](CNC3(C(F)(F)F)CC3)CC2)c2c1cnc1[nH]ccc21 CHEMBL3938113 IC50 6.4 nM
CCN1CN([C@H]2CC[C@H](CNS(=O)(=O)CC(F)(F)F)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3893247 IC50 6.4 nM
CCc1cc(O)ccc1-c1ccc2c(-c3nc4c([nH]3)CN(C)CC4)n[nH]c2c1 CHEMBL4066236 IC50 6.4 nM
Cc1cnc(Nc2ccc(N3CCOCC3)cc2)nc1-c1cc2c(o1)CCN(C(=O)C(C)C)C2 CHEMBL4524537 IC50 6.4 nM
CC(=O)Nc1ccc(-c2ccnc(Nc3cccc(N4CCCCC4)c3)n2)cc1 CHEMBL2208024 IC50 6.5 nM
COCN1CN([C@H]2CC[C@H](CN(C)CC(F)(F)F)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3961430 IC50 6.5 nM
Clc1cccc(Cl)c1-c1nc2ccnc(Nc3cc(N4CCOCC4)ncn3)c2[nH]1 CHEMBL4093872 Ki 6.5 nM
C=CC(=O)N1CCCC(n2nc(-c3cc(C(C)(C)O)n(C)n3)c3c(N)ncnc32)C1 CHEMBL4454392 IC50 6.5 nM
Cc1cnc(Nc2ccc(C3CCN(C)CC3)c(F)c2)nc1Nc1ccc(F)c(NS(=O)(=O)C(C)(C)C)c1 CHEMBL4785050 IC50 6.5 nM
C=CC(=O)N1CCCC(N2NC(c3cc(C(C)(C)O)n(C)n3)c3c(N)ncnc32)C1 CHEMBL5272587 IC50 6.5 nM
CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3nc4cccc(-c5ccccc5)n4n3)cc2)CC1 CHEMBL3642308 IC50 6.6 nM
CN1CCC(c2ccc(Nc3nc4c(Nc5ccccc5S(C)(=O)=O)cccn4n3)cc2)CC1 CHEMBL3642348 IC50 6.6 nM
O=C1SCCC1NC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3920091 IC50 6.6 nM
O=C(Nc1nccc2cc(-c3c(Cl)cccc3Cl)sc12)C1CC1 CHEMBL4093172 Ki 6.6 nM
O=C(CCCCCCC(=O)Nc1ccc(-c2ccnc(Nc3cccc(N4CCCCC4)c3)n2)cc1)NO CHEMBL4277267 IC50 6.6 nM
N#CCCNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 CHEMBL4563534 IC50 6.6 nM
COc1cccc(-c2cccn3nc(Nc4ccc5c(c4)CNC5)nc23)c1 CHEMBL3645060 IC50 6.63 nM
Cc1cnc(Nc2ccc3c(c2)CCN3C(=O)C2CC2(F)F)nc1-c1cnn(C(C)C)c1 CHEMBL4864674 IC50 6.65 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCN(Cc2ccc(Cl)cn2)[C@@H](C)C1 CHEMBL5423944 IC50 6.68 nM
CC(C#N)[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3945399 IC50 6.7 nM
CN(C[C@H]1CC[C@H](N2CN(C3CC3)C(=O)c3cnc4[nH]ccc4c32)CC1)S(C)(=O)=O CHEMBL3898972 IC50 6.7 nM
CN1CCN(c2ccc(-c3cnc4cccc(-c5cc(F)c(CN6CCS(=O)(=O)CC6)c(F)c5)c4n3)cn2)CC1 CHEMBL1092925 IC50 6.8 nM
NC(=O)c1cc(-c2ccc(Cl)cc2Cl)cc2c1[nH]c1ccc(C(=O)N3CCOCC3)cc12 CHEMBL3589167 IC50 6.8 nM
CN(CC(F)(F)F)C[C@H]1CC[C@H](N2CN(CC#N)C(=O)c3cnc4[nH]ccc4c32)CC1 CHEMBL3968872 IC50 6.8 nM
c1cc2c(NC3CCCCC3)c(-c3cn[nH]c3)cnc2[nH]1 CHEMBL5439066 IC50 6.85 nM
C[C@@H]1C[C@@H](CS(=O)(=O)N2CCC[C@@H](O)C2)CC[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL3652398 IC50 6.89 nM
CC(=O)Nc1ccc(-c2ccnc(Nc3cccc(NC(=O)c4ccccc4Cl)c3)n2)cc1 CHEMBL2207766 IC50 6.9 nM
O=C(CCCCCC(=O)Nc1ccc(NCCOc2ccc3cc2COC/C=C/COCc2cccc(c2)-c2ccnc(n2)N3)cc1)NO CHEMBL3933593 IC50 6.9 nM
C[C@H](Nc1cc(N(C)C)nc(-n2cnc3ccncc32)n1)c1ccccc1 CHEMBL218579 IC50 7.0 nM
CCN(CC)C(=O)C1CCCN(c2cc(-c3c(N)nn4cccnc34)ncn2)C1 CHEMBL1204012 Ki 7.0 nM
CNc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2)ncc1Cl CHEMBL2171748 Ki 7.0 nM
Cc1cnc2nc1-c1cccc(c1)COCC=CCOCc1cc(ccc1OCCN1CCCC1)N2 CHEMBL2181088 IC50 7.0 nM
O=c1[nH]ccc2c(Nc3c(F)cc(F)cc3F)nc3ccncc3c12 CHEMBL3126340 IC50 7.0 nM
O=C(Nc1cnc2[nH]ccc2n1)NC1CCCN(CC(F)(F)F)C1 CHEMBL3335678 IC50 7.0 nM
N#C[C@H]1C[C@@H](N2CC3(CCC3)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@H](O)C(F)(F)F)cc2)n1 CHEMBL3703059 IC50 7.0 nM
C[C@](O)(c1ccc(Nc2nn([C@H]3CC[C@H](N4CCC4)C[C@@H]3C#N)cc2C(N)=O)cc1)C(F)(F)F CHEMBL3703050 IC50 7.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1N1CCc2nc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3)ncc2C1 CHEMBL3658096 IC50 7.0 nM
CC(C)(C(=O)O)c1ccc(Nc2nn([C@@H]3CCCC[C@H]3C#N)cc2C(N)=O)cc1 CHEMBL3699544 IC50 7.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1N1CCc2nc(Nc3ccc(N4CCNCC4)cc3)ncc2C1=O CHEMBL3658125 IC50 7.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1N1CCc2nc(Nc3ccc(C(=O)NCCO)cc3)ncc2C1 CHEMBL3658098 IC50 7.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2cnc3c(c2)CNC3=O)n1 CHEMBL3702897 IC50 7.0 nM
CNC(=O)c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3639983 IC50 7.0 nM
CN([C@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1)C1(C)COC1 CHEMBL3647805 IC50 7.0 nM
N#C[C@H]1CC(NC2CC2)CCC1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3702975 IC50 7.0 nM
N#C[C@H]1CC(NC2CCS(=O)(=O)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647729 IC50 7.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)NCc3ccc(C(F)(F)F)cc3)cc2)n1 CHEMBL3702917 IC50 7.0 nM
CC(C)[C@H](C)n1cc(-c2ccc(N3CCOCC3)cn2)c2[nH]nc(N)c2c1=O CHEMBL3763991 IC50 7.0 nM
CN1CCN(C(=O)c2ccc3c(c2)[nH]c2c(C(N)=O)cc(-c4ccc(Cl)nc4)cc23)CC1 CHEMBL3646818 IC50 7.0 nM
COc1cccc(-c2cc(C(N)=O)c3[nH]c4cc(C(=O)N5CCN(C(=O)C6CC6)CC5)ccc4c3c2)c1 CHEMBL3646825 IC50 7.0 nM
COc1cccc(-c2cc(C(N)=O)c3[nH]c4cc(NC(=O)OCCN)ccc4c3c2)c1 CHEMBL3646829 IC50 7.0 nM
NC(=O)c1cc(-c2ccc(F)c(F)c2)nc2c1[nH]c1cc(C(=O)N3CCOCC3)ccc12 CHEMBL3646847 IC50 7.0 nM
NC(=O)c1cc(-c2ccc(Cl)c(Cl)c2)nc2c1[nH]c1cc(OCCN3CCOCC3)ccc12 CHEMBL3646849 IC50 7.0 nM
NC(=O)c1cc(-c2ccc(OC3CCNCC3)c(Cl)c2)nc2c1[nH]c1cc(N3CCOCC3)ccc12 CHEMBL3649619 IC50 7.0 nM
Cn1ncc2ccc(-c3cc(C(N)=O)c4[nH]c5cc(C(=O)N6CCOCC6)ccc5c4n3)cc21 CHEMBL3649632 IC50 7.0 nM
Cc1cc(-c2cc(C(N)=O)c3[nH]c4cc(N5CCOCC5)ccc4c3n2)ccc1Cl CHEMBL3649645 IC50 7.0 nM
CC(C)(C)OC(=O)N1CC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(C)(=O)=O)cc3)n2)C1 CHEMBL4107213 IC50 7.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C#N)c(F)c3)n2)CC1 CHEMBL3953347 IC50 7.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(C(N)=O)c3)n2)CC1 CHEMBL3924220 IC50 7.0 nM
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)nc3)n2)CC1 CHEMBL3940671 IC50 7.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ccccc2Cl)CC1 CHEMBL3955398 IC50 7.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(Nc2ccccc2Cl)CC1 CHEMBL3951300 IC50 7.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(Nc2ccccc2F)CC1 CHEMBL3896010 IC50 7.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(Nc2cccnc2)CC1 CHEMBL3914703 IC50 7.0 nM
N#C[C@@H]1CCOC[C@H]1n1cc(C(N)=O)c(Nc2cncc(F)c2)n1 CHEMBL3928267 IC50 7.0 nM
CN(c1nc(Nc2cnn(C)c2)ncc1Cl)C1CCC2(CCCN(C(=O)CC#N)C2)C1 CHEMBL3931866 IC50 7.0 nM
N#CCNC[C@H]1CC[C@H](N2CNC(=O)c3cnc4[nH]ccc4c32)CC1 CHEMBL3981587 IC50 7.0 nM
N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2cc(F)c3nccc(Cl)c3c2)n1 CHEMBL4076473 IC50 7.0 nM
Cc1ncnc2ccc(Nc3nn([C@H]4COCC[C@@H]4C#N)cc3C(N)=O)cc12 CHEMBL4079092 IC50 7.0 nM
O=C(CCCCCn1cc(Nc2ncc(Cl)c(Nc3cccc(Cl)c3)n2)cn1)NO CHEMBL4462229 IC50 7.0 nM
Cc1cnc(Nc2ccc3c(c2)CCN(CC#N)C3)nc1-c1cnn(C(C)C)c1 CHEMBL4798378 IC50 7.0 nM
N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCC(N5CCOCC5)CC4)cc3)n2)cc1 CHEMBL5179590 IC50 7.0 nM
C[C@@H]1CCN(C(=O)N2CCCCC2)C[C@@H]1n1c(=O)[nH]c2cnc3[nH]ccc3c21 CHEMBL5284080 IC50 7.0 nM
Cc1cnc(Nc2ccc(CNC(=O)/C=C/C(=O)c3ccccc3)cc2)nc1-c1cnn(C(C)C)c1 CHEMBL5403283 IC50 7.0 nM
Cc1cc(Nc2ncc(C)c(N3CC(CC#N)(N4CCCC4)C3)n2)sn1 CHEMBL5430060 IC50 7.0 nM
Cc1cnc2nc1-c1cccc(c1)COC/C=C/COCc1cc(ccc1OCCN1CCCC1)N2 CHEMBL5439075 IC50 7.0 nM
COc1cc(C(F)(F)F)ccc1-c1cccc2nc(Nc3ccc4c(c3)CCN(CCS(C)(=O)=O)CC4)nn12 CHEMBL3644977 IC50 7.01 nM
O=C(Nc1cn(CC(=O)N2CCC(N(Cc3ccccc3)CC(F)(F)F)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3949479 Ki 7.04 nM
Cc1cc(-c2cnc3cccc(-c4ccc(CN5CCS(=O)(=O)CC5)cc4)c3n2)ccc1C(=O)N1CCN(C)CC1 CHEMBL1092063 IC50 7.1 nM
O=C(Nc1ccncc1-c1cccc(Cl)c1)c1cnn2cccnc12 CHEMBL2178249 Ki 7.1 nM
Fc1ccc(C2(NC[C@H]3CC[C@H](c4nnn5cnc6[nH]ccc6c45)CC3)COC2)cc1 CHEMBL3926516 IC50 7.1 nM
C[C@@H]1CCN(C(=O)N2CCCC2)C[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL4068357 IC50 7.1 nM
C=CC(=O)N1CCC(n2nc(-c3cc(C(C)(C)O)n(C)n3)c3c(N)ncnc32)C1 CHEMBL4557416 IC50 7.2 nM
N#CC[C@H]1CC[C@H](n2c(CC(=O)N[C@H]3CC[C@H](O)CC3)nc3cnc4[nH]ccc4c32)CC1 CHEMBL4582390 IC50 7.2 nM
C=CC(=O)N1CCC(N2NC(c3cc(C(C)(C)O)n(C)n3)c3c(N)ncnc32)C1 CHEMBL5279689 IC50 7.2 nM
CN1CCC(c2ccc(Nc3nc4c(-c5cccc(CN(C)S(C)(=O)=O)c5)cccn4n3)cc2)CC1 CHEMBL3642399 IC50 7.21 nM
Cc1cc(Nc2nc(N3CCN(C(=O)c4ccccc4Cl)CC3)nn3cccc23)n[nH]1 CHEMBL1682378 IC50 7.3 nM
C1=C/COCc2cc(ccc2OCCN2CCCC2)Nc2nccc(n2)-c2ccc(s2)COC/1 CHEMBL2035183 IC50 7.3 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1n1c(=O)n(C)c2cnc3[nH]ccc3c21 CHEMBL3593592 IC50 7.3 nM
N#CCC(=O)N(CC(F)(F)F)C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3975399 IC50 7.3 nM
C=CCN(CCOc1ccc(C)cc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1 CHEMBL3925455 Ki 7.3 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(C#N)cc4)cc23)CC[C@]1(C)N CHEMBL4091582 IC50 7.3 nM
CN(Cc1cccc(-c2cccn3nc(Nc4ccc(OCCN5CCCC5)cc4)nc23)c1)S(C)(=O)=O CHEMBL3642398 IC50 7.34 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(C(F)(F)F)cc2)[C@H](C)C1 CHEMBL5398372 IC50 7.39 nM
NC(=O)c1cc(-c2ccccc2)cc2c1[nH]c1cc(N3CCOCC3)ccc12 CHEMBL3589179 IC50 7.4 nM
NC(=O)c1cc(-c2ccccc2)cc2c1[nH]c1cc(C(=O)N3CCOCC3)ccc12 CHEMBL3589174 IC50 7.4 nM
COc1cc(C(F)(F)F)ccc1-c1cccc2nc(Nc3ccc4c(c3)CCNCC4)nn12 CHEMBL3644975 IC50 7.4 nM
FC(F)(F)c1nc2cc(NC[C@H]3CC[C@H](c4nnn5cnc6[nH]ccc6c45)CC3)ccc2[nH]1 CHEMBL3965670 IC50 7.4 nM
N#CCC(=O)N1CCC[C@@H](n2c(=O)[nH]c3cnc(Nc4ccc[nH]c4=O)nc32)C1 CHEMBL4587709 IC50 7.4 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC(O)(c3ccccc3)CC2)CC1 CHEMBL3652297 IC50 7.42 nM
CC(C)(O)COCc1cccc(Nc2sc(-c3c(F)cc(C(C)(C)O)cc3F)cc2C(N)=O)n1 CHEMBL3234895 IC50 7.5 nM
COc1cccc(-c2cccn3nc(Nc4ccc(C5CCNCC5)cc4)nc23)c1 CHEMBL3645062 IC50 7.6 nM
CN1CN([C@H]2CC[C@H](CN(C)S(C)(=O)=O)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3952221 IC50 7.6 nM
O=C1c2cnc3[nH]ccc3c2N([C@H]2CC[C@H](CN3CCCS3(=O)=O)CC2)CN1C1CC1 CHEMBL3911589 IC50 7.6 nM
Fc1ccc(C(F)(F)F)cc1-c1cccn2nc(Nc3ccc4c(c3)CCNCC4)nc12 CHEMBL3645002 IC50 7.64 nM
CC(=O)OC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3892296 IC50 7.7 nM
CS(=O)(=O)CCn1cc(-c2nc(Nc3ccc(NC(=O)CCCCCCC(=O)NO)cc3)nc3[nH]ccc23)cn1 CHEMBL4237600 IC50 7.7 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCCC(C(=O)O)C2)CC1 CHEMBL3652289 IC50 7.71 nM
Nc1nn2cccnc2c1-c1cc(OCc2ccc(F)cc2)ncn1 CHEMBL568815 IC50 7.8 nM
CNc1nc2c(cc(-c3nnnn3C3CC3)n2C[C@H](O)CO)c2c1ncn2C CHEMBL3622138 IC50 7.8 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4ccccc4[nH]3)n[nH]c2c1 CHEMBL4103980 IC50 7.9 nM
CC(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCN(C)CC4)cc3)n2)cc1 CHEMBL4290297 IC50 7.9 nM
CCc1cc(O)c(F)cc1-c1cc(NS(=O)(=O)c2ccccc2Cl)c2cn[nH]c2c1 CHEMBL4560212 pIC50 7.943 nM
CCc1cc(O)c(F)cc1-c1cc(NS(=O)(=O)C(C)C)c2cn[nH]c2c1 CHEMBL4517645 pIC50 7.943 nM
CCc1cc(O)c(F)cc1-c1cc(NS(C)(=O)=O)c2cn[nH]c2c1 CHEMBL4539949 pIC50 7.943 nM
CCS(=O)(=O)Nc1cc(-c2ccc(O)c(F)c2)cc2[nH]ncc12 CHEMBL4516561 pIC50 7.943 nM
CCc1cc(O)c(F)cc1-c1cc(NCCCO)c2nc(N)ncc2c1 CHEMBL5084340 pIC50 7.943 nM
CCc1cc(O)c(F)cc1-c1cc(NCCNC)c2nc(N)ncc2c1 CHEMBL5076068 pIC50 7.943 nM
CN1CCN(c2ccc(Nc3nc4c(-c5cccc(CN(C)S(C)(=O)=O)c5)cccn4n3)cc2)CC1 CHEMBL3642396 IC50 7.95 nM
O=C(Nc1cn(CC(=O)N2CCC(N(CCc3ccccc3)CC(F)(F)F)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3910000 Ki 7.95 nM
C[C@H](Nc1ccnc(-n2cnc3ccncc32)n1)c1ccc(F)cc1 CHEMBL221976 IC50 8.0 nM
C[C@@H](Nc1cc(-c2c(N)nn3cccnc23)ncn1)c1ccc(Cl)cc1 CHEMBL570206 IC50 8.0 nM
COc1cc(Nc2nc3cccc(-c4ccc5ncccc5c4)c3o2)cc(OC)c1OC CHEMBL1081975 IC50 8.0 nM
COc1cc(Nc2nc3cccc(-c4ccc(C(=O)N5CCOCC5)cc4)c3o2)cc(OC)c1OC CHEMBL1081978 IC50 8.0 nM
Cc1cc(Nc2nc3cccc(-c4ccc(C(=O)N5CCOCC5)cc4)c3o2)ccc1C(=O)N(C)C CHEMBL1081664 IC50 8.0 nM
Cc1cc(-c2cccc3nc(Nc4ccc(N5CCN(C)CC5)cc4)oc23)ccc1C(=O)N1CCOCC1 CHEMBL1082023 IC50 8.0 nM
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3cccc(CN4CCOCC4)c3)n2)cc1 CHEMBL1078277 IC50 8.0 nM
Cc1cnc(Nc2ccc(N3CCOCC3)cc2)nc1-c1ccc(C(=O)NCC#N)cc1 CHEMBL1078005 IC50 8.0 nM
NC(=O)c1cnc(N[C@H](C2CC2)C(F)(F)F)c2c1[nH]c1cc(-c3cnc(N4CCOCC4)nc3)ccc12 CHEMBL1835151 IC50 8.0 nM
CC(C)(C)NS(=O)(=O)c1ccc(-c2cc3c(N)ncc(C(=O)NCCO)c3s2)cc1 CHEMBL1938655 IC50 8.0 nM
CN(C)CCNC(=O)c1cnc(N)c2cc(-c3ccc(S(=O)(=O)NC(C)(C)C)cc3)sc12 CHEMBL1938657 IC50 8.0 nM
CS(=O)(=O)c1cccc(-c2cccn3nc(Nc4ccccc4)nc23)c1 CHEMBL2062795 IC50 8.0 nM
CC(C)c1cccc(-c2cccc3nc(NC(=O)C4CC4)nn23)c1 CHEMBL2414560 Ki 8.0 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1cc(C(F)(F)F)ccc1Cl CHEMBL3330125 IC50 8.0 nM
CCc1ccc(Cl)cc1-n1cc(-c2cc(N)ncn2)cc1C(N)=O CHEMBL3403543 IC50 8.0 nM
CCCOc1cccc(-c2cc(C(N)=O)c3[nH]c4ccc(C(=O)N5CCOCC5)cc4c3c2)c1 CHEMBL3589168 IC50 8.0 nM
CC(C)N[C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647747 IC50 8.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1N1CCc2nc(Nc3ccc(C(N)=O)nc3)ncc2C1 CHEMBL3658104 IC50 8.0 nM
C[C@]1(C#N)CC[C@H](F)C[C@@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 CHEMBL3647933 IC50 8.0 nM
CS(=O)(=O)N[C@@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3647914 IC50 8.0 nM
N#C[C@H]1C[C@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(CC(F)(F)F)cc2)n1 CHEMBL3703031 IC50 8.0 nM
N#C[C@H]1C[C@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1 CHEMBL3702942 IC50 8.0 nM
N#C[C@H]1C[C@H](O)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(OC(F)F)cc2)n1 CHEMBL3702956 IC50 8.0 nM
N#C[C@H]1C[C@@H](NCC2CC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3647745 IC50 8.0 nM
N#C[C@H]1CCCCC1n1cc(C(N)=O)c(Nc2ccc3c(c2)CCC(=O)N3)n1 CHEMBL3699512 IC50 8.0 nM
C[C@](O)(c1ccc(Nc2nn([C@H]3CC[C@@H](N4CCC4)C[C@@H]3C#N)cc2C(N)=O)cc1)C(F)(F)F CHEMBL3703034 IC50 8.0 nM
Cn1c(C(=O)NCCN2CCCC2)cc2c(-c3ccc(NC(=O)C(C)(C)C)cc3)ncnc21 CHEMBL3799882 IC50 8.0 nM
Cc1ccc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)cn1 CHEMBL3963918 IC50 8.0 nM
Cc1nc(-c2ccc(Nc3nn(C4(CC#N)CCN(C(=O)OC(C)(C)C)CC4)cc3C(N)=O)cc2)no1 CHEMBL3901465 IC50 8.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ccc(O)nc2)CC1 CHEMBL3905008 IC50 8.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(C(=O)OCC(F)(F)F)CC1 CHEMBL3905579 IC50 8.0 nM
CC(CO)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1 CHEMBL3958861 IC50 8.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(C(=O)c2cccs2)CC1 CHEMBL3940586 IC50 8.0 nM
CC(C)(O)CC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1 CHEMBL3905407 IC50 8.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(S(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1 CHEMBL3908689 IC50 8.0 nM
Cc1ncoc1CN1CC[C@@H](C#N)[C@H](n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1 CHEMBL3917134 IC50 8.0 nM
Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC(F)(F)F)CC4C3)n2)cn1 CHEMBL3961729 IC50 8.0 nM
N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCC(C(=O)Nc5ccccc5N)CC4)cc3)n2)cc1 CHEMBL4170168 IC50 8.0 nM
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCC(C(=O)Nc5ccc(/C=C/C(=O)NO)cc5)CC4)cc3)n2)cc1 CHEMBL4175555 IC50 8.0 nM
Cn1nc(-c2nn(C3CCCN(C(=O)CC#N)C3)c3ncnc(N)c23)cc1C(C)(C)O CHEMBL4590390 IC50 8.0 nM
Cn1cc(Nc2ncc(F)c(N3C[C@H]4CC[C@H](C3)N4C(=O)C3CC3)n2)cn1 CHEMBL4580985 fIC50 8.0 nM
CC(Oc1cc(-c2cnn(C3CCOCC3)c2)cnc1N)c1cc(F)ccc1Cl CHEMBL4644279 IC50 8.0 nM
Cn1cc(-c2cn3nccc3c(-c3cnn([C@]4(CC#N)C[C@H](C#N)C4)c3)n2)cn1 CHEMBL4740298 IC50 8.0 nM
Cc1nc(Cl)cc(Nc2c[nH]nc2-c2nc(-c3ccc(CN4CCOCC4)cc3)c[nH]2)n1 CHEMBL4794655 IC50 8.0 nM
N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCC(N5CC6CC(C5)O6)CC4)cc3)n2)cc1 CHEMBL5208298 IC50 8.0 nM
Cc1nnc(C2CCN(c3ccc(Nc4nccc(-c5ccc(C(=O)NCC#N)cc5)n4)cc3)CC2)o1 CHEMBL5192393 IC50 8.0 nM
Cn1nc(C2NN(C3CCCN(C(=O)CC#N)C3)c3ncnc(N)c32)cc1C(C)(C)O CHEMBL5279426 IC50 8.0 nM
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCC(CCc5ccc(/C=C/CC(=O)NO)cc5)CC4)cc3)n2)cc1 CHEMBL5272716 IC50 8.0 nM
COc1ccccc1Nc1cc(Nc2ccccn2)ncc1C(N)=O CHEMBL5409666 IC50 8.0 nM
C=CC(=O)NCc1ccc(Nc2ncc(C)c(-c3cnn(C(C)C)c3)n2)cc1 CHEMBL5432626 IC50 8.0 nM
Cc1cc(Nc2ncc(C)c(N3CC(CC#N)(OC4CC5(CC5)C4)C3)n2)sn1 CHEMBL5436997 IC50 8.0 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@@H](O)C2)CC1 CHEMBL3652312 IC50 8.04 nM
N#CCNC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3955720 IC50 8.1 nM
CN1CN([C@H]2CC[C@H](CF)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3936358 IC50 8.1 nM
Fc1ccc(-c2cccn3nc(Nc4ccc(C5CCNCC5)cc4)nc23)cc1 CHEMBL3645059 IC50 8.12 nM
CNc1nc2c(cc(C(=O)N(C3CC3)C3CC3)n2C[C@H](O)CO)c2c1ncn2C CHEMBL3622127 IC50 8.2 nM
CN1CN([C@H]2CC[C@H](CNCC(F)F)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3967688 IC50 8.2 nM
Cc1cnc(Nc2cc(F)c(C3CCN(C)CC3)c(F)c2)nc1Nc1ccc(F)c(NS(=O)(=O)C(C)(C)C)c1 CHEMBL4744236 IC50 8.2 nM
OCc1nc2cnc3[nH]ccc3c2n1C1CCCCC1 CHEMBL2386637 Ki 8.3 nM
Clc1cnc2nc1NCc1cccc(c1)OCCOc1cccc(c1)N2 CHEMBL3694583 IC50 8.3 nM
CN1CCN(c2ccc(Nc3nc4c(Nc5ccccc5S(C)(=O)=O)cccn4n3)cc2)CC1 CHEMBL3642304 IC50 8.3 nM
CN(C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1)C(Cc1ccccc1)C(F)(F)F CHEMBL3932229 Ki 8.33 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@@H](CO)C2)CC1 CHEMBL3652303 IC50 8.36 nM
Cc1cnc(Nc2ccc(OCCCCCCC(=O)NO)c(F)c2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL5395502 IC50 8.36 nM
FC(F)(F)CNC[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3978202 IC50 8.4 nM
CN(C)S(=O)(=O)C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3956450 IC50 8.4 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CN(S(=O)(=O)c2cccc(F)c2)CC12CC2 CHEMBL4289789 IC50 8.4 nM
COc1cc(Cl)ccc1-c1cccn2nc(Nc3ccc4c(c3)CCN(CC(=O)N(C)C)CC4)nc12 CHEMBL3645042 IC50 8.48 nM
CS(=O)(=O)c1cccc(-c2cccn3nc(Nc4ccc(N5CCOCC5)cc4)nc23)c1 CHEMBL3642261 IC50 8.5 nM
CN(c1ncnc2[nH]ccc12)N1CC[C@@H](C(=O)NCC(F)(F)F)C1 CHEMBL5175400 IC50 8.5 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(Cl)nc2)[C@H](C)C1 CHEMBL5427932 IC50 8.5 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2C[C@@H](O)[C@@H](O)C2)CC1 CHEMBL3652342 IC50 8.54 nM
CC(C)(O)CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 CHEMBL4473572 IC50 8.6 nM
Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2CO)n1 CHEMBL4748712 Ki 8.6 nM
O=C(Nc1sc(N2CCN(CCc3ccccc3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12 CHEMBL3931929 Ki 8.67 nM
C[C@H](N)C(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL2208031 IC50 8.7 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(C(F)(F)F)nc2)[C@H](C)C1 CHEMBL5435417 IC50 8.78 nM
CN1CCN(c2ccc(Nc3ncc4c(n3)CCN(c3cc(NC(=O)c5cccc(C(F)(F)F)c5)ccc3Cl)C4)cc2)CC1 CHEMBL3658123 IC50 8.8 nM
N#CC(C#N)C[C@H]1CC[C@H](c2nnn3cnc4[nH]ccc4c23)CC1 CHEMBL3930389 IC50 8.8 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2cccc(Cl)c2)[C@H](C)C1 CHEMBL4779060 IC50 8.83 nM
CN1CCC(c2cccc(Nc3nc4c(-c5cccc(N(C)S(C)(=O)=O)c5)cccn4n3)c2)CC1 CHEMBL3642352 IC50 8.88 nM
NC(=O)CN1CCC(c2ccc(Nc3ncc4ccc(-c5cnccn5)n4n3)cc2)CC1 CHEMBL1934347 IC50 8.9 nM
Cc1cnc(Nc2ccc(N3CCOCC3)cc2)nc1-c1cc2ccccc2o1 CHEMBL3907087 IC50 8.9 nM
COc1cc2c(=O)n([C@@H]3CCCNC3)c3c4cc[nH]c4ncc3c2cc1OC CHEMBL4287893 IC50 8.91 nM
COCCC1(C(N)=O)CCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)CC1 CHEMBL3652317 IC50 8.97 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2cccc(F)c2)[C@H](C)C1 CHEMBL5396523 IC50 8.97 nM
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(CN4CCOCC4)cc3)n2)cc1 CHEMBL1078689 IC50 9.0 nM
C[C@H](Nc1ncc(Cl)c(Nc2cc(N(C)C)[nH]n2)n1)c1ncc(F)cn1 CHEMBL1650730 IC50 9.0 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)nc(N3CCOCC3)c2Cl)n[nH]1 CHEMBL1650734 IC50 9.0 nM
Cn1cc(-c2ccc3c(c2)[nH]c2c(C(N)=O)cnc(N[C@@H](C4CC4)C(F)(F)F)c23)cn1 CHEMBL1835143 IC50 9.0 nM
N#C[C@H]1CCC[C@H]1Nc1ncnc2c(=O)[nH]ccc12 CHEMBL2436965 Ki 9.0 nM
O=c1[nH]ccc2c(Nc3c(F)cccc3C(F)(F)F)nc3ccncc3c12 CHEMBL3126345 IC50 9.0 nM
Cc1ccc(Cl)cc1-c1cc(-c2ncnc3[nH]ccc23)[nH]c1C(N)=O CHEMBL3403552 IC50 9.0 nM
CC1(O)CN([C@@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3647772 IC50 9.0 nM
CCNC(=O)O[C@@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)[C@@H](C#N)C1 CHEMBL3647872 IC50 9.0 nM
CN1CCN(c2ccc(Nc3ncc4c(n3)CCN(c3cc(NC(=O)c5cc(F)cc(C(F)(F)F)c5)ccc3Cl)C4=O)cc2)CC1 CHEMBL3658122 IC50 9.0 nM
[C-]#[N+][C@@H]1C[C@H](OCC2CC2)CC[C@H]1n1cc(C(N)=O)c(Nc2ccnc(F)c2)n1 CHEMBL3702959 IC50 9.0 nM
N#C[C@H]1C[C@@H](N2CC3(CCC3)C2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@@H](O)C(F)(F)F)cc2)n1 CHEMBL3703036 IC50 9.0 nM
CC1CN([C@H]2CC[C@H](n3cc(C(N)=O)c(Nc4ccc(S(=O)(=O)C(F)(F)F)cc4)n3)[C@@H](C#N)C2)C1 CHEMBL3647759 IC50 9.0 nM
CS(=O)(=O)c1ccc(Nc2nn(C3CCCCC3C#N)cc2C(N)=O)cc1 CHEMBL3699477 IC50 9.0 nM
N#C[C@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)nc2)n1 CHEMBL3702922 IC50 9.0 nM
N#C[C@@H]1CCCC[C@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)Nc3ccccn3)cc2)n1 CHEMBL3702888 IC50 9.0 nM
N#C[C@@H]1CCCC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(S(=O)(=O)C(F)(F)F)cc2)n1 CHEMBL3650680 IC50 9.0 nM
N#C[C@H]1C[C@@H](NCc2ccccc2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccnc(F)c2)n1 CHEMBL3703068 IC50 9.0 nM
N#C[C@H]1C[C@H](OCC2CC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@H](O)C(F)(F)F)cc2)n1 CHEMBL3702965 IC50 9.0 nM
Cc1ccc(NC(=O)CC(C)C(F)(F)F)cc1N1CCc2nc(Nc3ccc(N4CCN(C)CC4)cc3)ncc2C1 CHEMBL3658106 IC50 9.0 nM
CC(=O)c1ccc(Nc2nn([C@H]3CC[C@H](N4CCC4)C[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3703055 IC50 9.0 nM
CN(C)[C@@H]1CCC(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)[C@@H](C#N)C1 CHEMBL3650674 IC50 9.0 nM
Cc1cccc(C)c1NS(=O)(=O)c1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3702909 IC50 9.0 nM
N#Cc1ccc(Nc2nn([C@H]3CCCC[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3699506 IC50 9.0 nM
C[C@]1(O)CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1 CHEMBL3647840 IC50 9.0 nM
N#Cc1ccc(Nc2nn([C@H]3CC[C@H](NCC(F)F)C[C@@H]3C#N)cc2C(N)=O)cc1 CHEMBL3703084 IC50 9.0 nM
COc1ccccc1Nc1cc[nH]c(=O)c1C(=O)Nc1ccc(N2CCN(C)CC2)cc1 CHEMBL3780090 Ki(app) 9.0 nM
Cn1c(C(=O)NCCN2CCCC2)cc2c(-c3ccc(NC(=O)[C@@H]4CCCN4C(=O)OC(C)(C)C)cc3)ncnc21 CHEMBL3797831 IC50 9.0 nM
O=C(NO)c1cccc(NCCOc2ccc3cc2COC/C=C/COCc2cccc(c2)-c2ccnc(n2)N3)c1 CHEMBL3952364 IC50 9.0 nM
N#CC1CC12CCC(c1nnn3cnc4[nH]ccc4c13)CC2 CHEMBL3962051 IC50 9.0 nM
COc1ccc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)cn1 CHEMBL3933722 IC50 9.0 nM
COC(=O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1 CHEMBL3967992 IC50 9.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(Cc2cccnc2)CC1 CHEMBL3922288 IC50 9.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(Cc2ccc(C#N)cc2)CC1 CHEMBL3901593 IC50 9.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)OCC(F)F)CC1 CHEMBL3893287 IC50 9.0 nM
C[C@H](OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1)C1CC1 CHEMBL3962716 IC50 9.0 nM
N#CCC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1 CHEMBL3933409 IC50 9.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(C(=O)CCC(F)(F)F)CC1 CHEMBL3981780 IC50 9.0 nM
Cn1cnc(S(=O)(=O)N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccccc4)n3)CC2)c1 CHEMBL3907066 IC50 9.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)CCN(S(=O)(=O)c2ccccc2Cl)CC1 CHEMBL3979025 IC50 9.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(Nc2ccc(F)cc2)CC1 CHEMBL3947052 IC50 9.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCC(N2CCC(F)(F)CC2)CC1 CHEMBL3952669 IC50 9.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(NCc2ccc(F)cc2)CC1 CHEMBL3937127 IC50 9.0 nM
N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(NCc2cccc(F)c2)CC1 CHEMBL3970367 IC50 9.0 nM
C[C@@](O)(c1ccc(Nc2nn([C@@H]3COCC[C@H]3C#N)cc2C(N)=O)cc1)C(F)F CHEMBL3959433 IC50 9.0 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccccc4)cc23)CC[C@]1(C)N CHEMBL4096145 IC50 9.0 nM
Cc1cnc(Nc2ccc3c(c2)CN(C(=O)/C=C/CN(C)C)CC3)nc1-c1cnn(C(C)C)c1 CHEMBL4756422 IC50 9.0 nM
Cc1cnc(Nc2ccc(N3C4CCC3COC4)cc2)nc1N1CCC2(CCNC2=O)CC1 CHEMBL5091163 IC50 9.0 nM
Cc1cc(Nc2ncc(C)c(N3CC(CC#N)C3)n2)sn1 CHEMBL5417435 IC50 9.0 nM
NC(=O)c1nnc(-c2c(F)cccc2Cl)cc1Nc1ccc(N2CCOCC2)cc1 CHEMBL5440264 IC50 9.0 nM
CN(CC1(C#N)CCCCC1)C1CCN(C(=O)c2ccc(-n3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)cc2)CC1 CHEMBL3958362 Ki 9.03 nM
COc1ccc(-c2cccn3nc(Nc4ccc(C5CCNCC5)cc4)nc23)c(F)c1 CHEMBL3645074 IC50 9.04 nM
CCN1CCC[C@@H]1C(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL2207760 IC50 9.1 nM
Cc1cccc(Nc2nc3cccc(-c4cccc(C(C)C)c4)n3n2)c1 CHEMBL2414552 Ki 9.1 nM
FC(F)(F)c1ccc(-c2cccn3nc(Nc4cnn(CCN5CCCC5)c4)nc23)cc1 CHEMBL3644964 IC50 9.1 nM
CN1Cc2ccc(Nc3nc4c(NCc5ccccc5N(C)S(C)(=O)=O)cccn4n3)cc2C1 CHEMBL3642388 IC50 9.19 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC(S(=O)(=O)c3ccccc3)C2)CC1 CHEMBL3652384 IC50 9.2 nM
CC(=O)Nc1ccc(-c2ccnc(Nc3cccc(NC(=O)CCCCCCC(=O)NO)c3)n2)cc1 CHEMBL4282456 IC50 9.2 nM
Cc1cnc(Nc2ccc(F)cc2)nc1-c1cc2c(o1)CCN(C(=O)CC#N)C2 CHEMBL4471390 IC50 9.2 nM
N#CC[C@H]1CC[C@H](n2c(CC(=O)NCc3ccc(F)cc3)nc3cnc4[nH]ccc4c32)CC1 CHEMBL4588333 IC50 9.2 nM
Cc1cc(Nc2nc(N3CCN(C(=O)N(C)C)CC3)nn3cccc23)n[nH]1 CHEMBL1682370 IC50 9.3 nM
Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](NCCC#N)CC1 CHEMBL2159205 Ki 9.3 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC[C@@](O)(Cn3cccn3)C2)CC1 CHEMBL3652361 IC50 9.3 nM
CS(=O)(=O)c1ccc(-c2cccc3nc(Nc4cccc(S(C)(=O)=O)c4)nn23)cc1 CHEMBL3642323 IC50 9.3 nM
NS(=O)(=O)c1ccc(NC(=O)N2CCN(c3ccnc(Nc4ccc(N5CCOCC5)cc4)n3)CC2)cc1 CHEMBL4536858 IC50 9.3 nM
COc1cc(Nc2ncc(F)c(-c3cc4c(o3)CCN(S(C)(=O)=O)C4)n2)cc(OC)c1OC CHEMBL3970092 IC50 9.4 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1-c1cc2c(o1)CCN(C(=O)CC#N)C2 CHEMBL4552039 IC50 9.6 nM
c1cc2c(NC3CCCC3)c(-c3cn[nH]c3)cnc2[nH]1 CHEMBL5409529 IC50 9.642 nM
Cc1cc(NC(=O)c2cnn3cccnc23)c(-c2cccc(Cl)c2)cn1 CHEMBL2178250 Ki 9.7 nM
C=CC(=O)N1CCC(n2nc(-c3cc(C=O)n(C)n3)c3c(N)ncnc32)C1 CHEMBL4561431 IC50 9.7 nM
Cn1nc(C2NN(C3CCCN(C(=O)CC#N)C3)c3ncnc(N)c32)cc1C=O CHEMBL5282475 IC50 9.7 nM
CS(=O)(=O)c1ccc(-n2ccc3cnc(Nc4cnn(CCCCCC(=O)NO)c4)nc32)cc1 CHEMBL5093377 IC50 9.8 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 9.9 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CC(c3nnn[nH]3)C2)CC1 CHEMBL3652383 IC50 9.99 nM