CC(C)CS(=O)(=O)N1CCC[C@H](Nc2nc(N)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665180 Ki 0.000578 nM
N#CCS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3335691 Ki 0.000748 nM
CC(C)CS(=O)(=O)N1CCC[C@H](Nc2nc(S(C)(=O)=O)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665182 Ki 0.00094 nM
CC(C)CS(=O)(=O)N1CCC[C@H](Nc2ncncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665179 Ki 0.00098 nM
CN1CCN(c2ncc(-c3cnc4[nH]ccc4n3)c(N[C@H]3CCCN(S(=O)(=O)CCC(C)(C)C)C3)n2)CC1 CHEMBL3665202 Ki 0.00109 nM
CC(C)(C)CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3335690 Ki 0.0012 nM
CSc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(=O)(=O)CCC(C)(C)C)C2)n1 CHEMBL3665188 Ki 0.00121 nM
C[C@H]1C[C@H](Nc2nc(N3CCN(C)CC3)ncc2-c2cnc3[nH]ccc3n2)CN(S(=O)(=O)CC#N)C1 CHEMBL3665216 Ki 0.00207 nM
CC(C)CS(=O)(=O)N1CC[C@@H](O)[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665175 Ki 0.0021 nM
CC(C)CS(=O)(=O)N1CCC[C@H](Nc2nc(N(C)C)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665181 Ki 0.00248 nM
C[C@H]1C[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)CN(S(=O)(=O)CC#N)C1 CHEMBL3665222 Ki 0.0026 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(N3CCC(CC(N)=O)CC3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665199 Ki 0.00265 nM
CC(C)CS(=O)(=O)N1CCC[C@H](Nc2nc(N3CCN(C)CC3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665214 Ki 0.00337 nM
CC(C)CS(=O)(=O)N1C[C@@H](C)C[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3335692 Ki 0.003435 nM
O=S(=O)(CC1CC1)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665152 Ki 0.00373 nM
CS(=O)(=O)N1CC[C@@H](O)[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665176 Ki 0.0038 nM
CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]cc(Cl)c3n2)C1 CHEMBL3665174 Ki 0.00386 nM
CCCS(=O)(=O)N1C[C@@H](C)C[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665142 Ki 0.003981 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(NCCO)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665192 Ki 0.00402 nM
CC[C@H](CO)Nc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(C)(=O)=O)C2)n1 CHEMBL3335696 Ki 0.00429 nM
CS(=O)(=O)N1CCC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665119 Ki 0.004294 nM
CSc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(=O)(=O)CC(C)C)C2)n1 CHEMBL3665183 Ki 0.00448 nM
CC(C)CS(=O)(=O)N1C[C@@H](C)C[C@H](Nc2nc(N3CCN(C)CC3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665215 IC50 0.005185 nM
CC(C)CS(=O)(=O)N1CCC[C@H](Nc2nc(N3CCOCC3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665184 Ki 0.00525 nM
COCCNc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(C)(=O)=O)C2)n1 CHEMBL3665193 Ki 0.00535 nM
CS(=O)(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665122 Ki 0.005369 nM
CC[C@@H](CO)Nc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(C)(=O)=O)C2)n1 CHEMBL3665200 Ki 0.00548 nM
Cc1c[nH]c2ncc(-c3cccnc3N[C@H]3CCCN(S(C)(=O)=O)C3)nc12 CHEMBL3665172 Ki 0.00587 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(N3CC(C#N)C3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665206 Ki 0.00625 nM
CC(=O)N1CCC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665123 Ki 0.006572 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(NC3CCC(C#N)CC3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665207 Ki 0.00679 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(N3CC[C@@H](O)C3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3335697 Ki 0.00756 nM
Cc1ccc(-c2cnc3[nH]ccc3n2)c(NC2CCCN(S(=O)(=O)CC(C)(C)C)C2)n1 CHEMBL3665150 Ki 0.008383 nM
CS(=O)(=O)N1CCC[C@H](Nc2[nH]c(=O)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3335695 Ki 0.0086 nM
CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]cc(C#N)c3n2)C1 CHEMBL3665171 Ki 0.00867 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(N)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3335694 Ki 0.00893 nM
CS(=O)(=O)N1CC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665128 Ki 0.009203 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(N3CCOCC3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3335698 Ki 0.00931 nM
Cc1ccc(-c2cnc3[nH]ccc3n2)c(NC2CCCN(S(C)(=O)=O)C2)n1 CHEMBL3665146 Ki 0.009688 nM
CC(C)CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3335689 Ki 0.01046 nM
CN1CCN(c2ncc(-c3cnc4[nH]ccc4n3)c(N[C@H]3CCCN(S(C)(=O)=O)C3)n2)CC1 CHEMBL3335699 Ki 0.01055 nM
CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]cc(C4CC4)c3n2)C1 CHEMBL3665173 Ki 0.01074 nM
CN(C)[C@@H]1CCN(c2ncc(-c3cnc4[nH]ccc4n3)c(N[C@H]3CCCN(S(C)(=O)=O)C3)n2)C1 CHEMBL3665213 Ki 0.01081 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(N3CCC(CC(=O)O)CC3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665209 Ki 0.01167 nM
CC(C)CS(=O)(=O)N1CCC[C@H](Nc2nccnc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665167 Ki 0.01179 nM
CN1CCC(Nc2ncc(-c3cnc4[nH]ccc4n3)c(N[C@H]3CCCN(S(C)(=O)=O)C3)n2)CC1 CHEMBL3665201 Ki 0.01253 nM
CN(C)C1CCN(c2ncc(-c3cnc4[nH]ccc4n3)c(N[C@H]3CCCN(S(C)(=O)=O)C3)n2)CC1 CHEMBL3665203 Ki 0.01291 nM
C=C(C)C(=O)Nc1cc(-c2ncnc3[nH]cc(C(=O)OCC)c23)ccc1Cl CHEMBL3650991 IC50 0.013 nM
C=C(F)C(=O)Nc1cc(-c2ncnc3[nH]cc(C(=O)OCC)c23)ccc1F CHEMBL3651021 IC50 0.013 nM
C[C@H]1C[C@H](Nc2nc(N3CCN(C)CC3)ncc2-c2cnc3[nH]ccc3n2)CN(S(C)(=O)=O)C1 CHEMBL3665217 Ki 0.01339 nM
COc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(C)(=O)=O)C2)n1 CHEMBL3665189 Ki 0.01356 nM
COC1CCN(c2ncc(-c3cnc4[nH]ccc4n3)c(N[C@H]3CCCN(S(C)(=O)=O)C3)n2)CC1 CHEMBL3665197 Ki 0.01504 nM
CC(C)S(=O)(=O)N1C[C@@H](C)C[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665144 Ki 0.01517 nM
CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3335688 Ki 0.01553 nM
C=CC(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4ccccc4)c23)c1 CHEMBL3651050 IC50 0.016 nM
CCOc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(C)(=O)=O)C2)n1 CHEMBL3665191 Ki 0.01631 nM
CN(C)CCNc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(C)(=O)=O)C2)n1 CHEMBL3665211 Ki 0.01634 nM
Cc1ccc(-c2cnc3[nH]cc(Cl)c3n2)c(NC2CCCN(S(=O)(=O)CC3CC3)C2)n1 CHEMBL3665153 Ki 0.01754 nM
CS(=O)(=O)N1CCC[C@H](Nc2ncncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3335693 Ki 0.01878 nM
C[C@H]1C[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)CN(S(C)(=O)=O)C1 CHEMBL3665141 Ki 0.01905 nM
CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)CC1 CHEMBL3665151 Ki 0.01969 nM
CC(C)(O)CNc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(C)(=O)=O)C2)n1 CHEMBL3665195 Ki 0.01979 nM
Cc1ccc(-c2cnc3[nH]ccc3n2)c(NC2CCCN(S(=O)(=O)CC3CC3)C2)n1 CHEMBL3665149 Ki 0.01988 nM
C=C(CO)C(=O)Nc1cccc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 CHEMBL3651041 IC50 0.02 nM
CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NC(=O)/C=C/CN(C)C)c3)c12 CHEMBL3651060 IC50 0.02 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(N3CC[C@H](O)C3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665205 Ki 0.02131 nM
CSc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(C)(=O)=O)C2)n1 CHEMBL3665185 Ki 0.02368 nM
CN(C)S(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665177 Ki 0.02391 nM
C=C(F)C(=O)Nc1cccc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 CHEMBL3651015 IC50 0.024 nM
C=C(CF)C(=O)Nc1cccc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 CHEMBL3651040 IC50 0.024 nM
CCN1CCN(c2ncc(-c3cnc4[nH]ccc4n3)c(N[C@H]3CCCN(S(C)(=O)=O)C3)n2)CC1 CHEMBL3665212 Ki 0.02427 nM
CS(=O)(=O)N1CCC[C@H](Nc2nccnc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3357978 Ki 0.02468 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(N3CCS(=O)(=O)CC3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665196 Ki 0.02491 nM
C=C(COC)C(=O)Nc1cccc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 CHEMBL3651030 IC50 0.025 nM
CC(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665120 Ki 0.02511 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(NCCN)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665198 Ki 0.02518 nM
COC(=O)N1CCCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665130 Ki 0.02529 nM
CCS(=O)(=O)N1CCCC(Nc2nc(C)ccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665148 Ki 0.02549 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(Cl)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665190 Ki 0.0262 nM
CN(C)c1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(C)(=O)=O)C2)n1 CHEMBL3665186 Ki 0.02837 nM
CC(=O)N1CCCC(Nc2nc(C)ccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665145 Ki 0.03037 nM
CC(C)(C)NS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665178 Ki 0.03235 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(N3CCN(c4ccccn4)CC3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665208 Ki 0.03243 nM
CC(=O)N1CC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665126 Ki 0.03255 nM
C=CC(=O)Nc1cc(-c2ncnc3[nH]cc(C(=O)OCC)c23)ccc1C CHEMBL3650993 IC50 0.033 nM
CC(=O)N1CCCC(Nc2nc(C)ccc2-c2cnc3[nH]cc(Cl)c3n2)C1 CHEMBL3639640 Ki 0.03528 nM
COCCOC1CCCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 CHEMBL3652408 IC50 0.0368 nM
C=CS(=O)(=O)Nc1cccc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 CHEMBL3651032 IC50 0.037 nM
C=CC(=O)Nc1cccc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 CHEMBL3650988 IC50 0.04 nM
C[C@@H]1C[C@@H](CS(=O)(=O)N2CC[C@H](CO)C2)CC[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL3652402 IC50 0.0421 nM
C=C(Br)C(=O)Nc1cccc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 CHEMBL3651017 IC50 0.043 nM
C=C(C)C(=O)Nc1cc(-c2ncnc3[nH]cc(C(=O)OCC)c23)ccn1 CHEMBL3651014 IC50 0.049 nM
C=C(C)C(=O)Nc1cc(-c2ncnc3[nH]cc(C(=O)OCC)c23)cc(OC)n1 CHEMBL3650987 IC50 0.049 nM
N#CCC1(N2CCC[C@H](Nc3ncccc3-c3cnc4[nH]ccc4n3)C2)COC1 CHEMBL3665220 Ki 0.04998 nM
C=C(C)C(=O)Nc1cc(F)cc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 CHEMBL3650999 IC50 0.05 nM
CS(=O)(=O)N1CCCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665131 Ki 0.05062 nM
C=C(CNS(C)(=O)=O)C(=O)Nc1cccc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 CHEMBL3651037 IC50 0.052 nM
COc1nc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)ccc1C#N CHEMBL3951700 IC50 0.055 nM
CN(c1ccnc(Cl)n1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3941211 IC50 0.055 nM
CN(c1ccc(F)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3925605 IC50 0.055 nM
CN(c1ccc(Cl)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3920484 IC50 0.055 nM
CN(c1ccnc(C#N)c1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3937835 IC50 0.055 nM
CCN(c1ccc(C#N)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3893327 IC50 0.055 nM
C#CCN(c1c(F)cc(C#N)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3930290 IC50 0.055 nM
CN(c1cnc(N2CCOCC2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3942728 IC50 0.055 nM
C#Cc1ccc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)nc1 CHEMBL3960416 IC50 0.055 nM
C[C@@H](NC(=O)c1ccc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)c(F)c1)c1ccccc1 CHEMBL3951623 IC50 0.055 nM
CN(c1c(F)cc(C(=O)N[C@H](CO)c2ccccc2)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3890208 IC50 0.055 nM
COC[C@@H](NC(=O)c1cc(F)c(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)c(F)c1)c1ccccc1 CHEMBL3956882 IC50 0.055 nM
CN(c1ccc(S(=O)(=O)NC2CC2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3917906 IC50 0.055 nM
CC(=O)N1CCCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665129 Ki 0.05509 nM
CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NC(=O)C4(C)CO4)c3)c12 CHEMBL3651042 IC50 0.056 nM
CCCS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ncc3n2)C1 CHEMBL3665157 Ki 0.0651 nM
C=CC(=O)Nc1cc(-c2ncnc3[nH]cc(C(=O)OCC)c23)ccc1Cl CHEMBL3650995 IC50 0.066 nM
CC(C)CS(=O)(=O)N1C[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C[C@H](C(F)(F)F)C1 CHEMBL3665219 Ki 0.06732 nM
C=C(C)C(=O)Nc1cc(C#N)cc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 CHEMBL3651003 IC50 0.068 nM
C=C(C)C(=O)Nc1cc(-c2ncnc3[nH]cc(C(=O)OCC)c23)ccc1F CHEMBL3650996 IC50 0.07 nM
CC#CC(=O)Nc1cccc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 CHEMBL3651016 IC50 0.072 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(Nc3ccncc3)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665210 Ki 0.07654 nM
CS(=O)(=O)N1CCC[C@H](Nc2nc(C#N)ncc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665204 Ki 0.08035 nM
C=CC(=O)N1CCc2ccc(-c3ncnc4[nH]cc(C(=O)OCC)c34)cc21 CHEMBL3651000 IC50 0.081 nM
C=C(C)C(=O)Nc1cncc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 CHEMBL3650986 IC50 0.085 nM
C=C(C)C(=O)Nc1cc(-c2ncnc3[nH]cc(C(=O)OCC)c23)ccc1S(C)(=O)=O CHEMBL3651008 IC50 0.087 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.0913 nM
C[C@H]1C[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)CN(C2(CC#N)COC2)C1 CHEMBL3665221 Ki 0.09486 nM
CCS(=O)(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665133 Ki 0.09843 nM
CCC(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665137 Ki 0.09995 nM
C=CC(=O)Nc1cccc(Cn2ncc3cnc(Nc4cnn(CCOC)c4)nc32)c1 CHEMBL4748313 IC50 0.1 nM
FC(F)(F)CN1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665147 Ki 0.1029 nM
C=C(C)C(=O)Nc1cc(-c2ncnc3[nH]cc(C(=O)OCC)c23)ccc1OC CHEMBL3650997 IC50 0.11 nM
C=C(C)C(=O)Nc1ccc(F)c(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 CHEMBL3650998 IC50 0.11 nM
C=C(C)C(=O)Nc1cc(-c2ncnc3[nH]cc(C(=O)OCC)c23)ccc1O CHEMBL3651010 IC50 0.11 nM
C=C(C)C(=O)Nc1cc(-c2ncnc3[nH]cc(C(=O)OCC)c23)ccc1CO CHEMBL3651004 IC50 0.11 nM
C=CC(=O)Nc1cc(-c2ncnc3[nH]cc(C(=O)OCC)c23)ccc1OC CHEMBL3639498 IC50 0.11 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1n1ccc2cnc3[nH]cc(C#N)c3c21 CHEMBL5273533 IC50 0.11 nM
COC(=O)N1CC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665127 Ki 0.1128 nM
CC(C)(C)[C@@H](NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N1CC(C#N)C1 CHEMBL2325895 Kd 0.12 nM
CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ncc3n2)C1 CHEMBL3665156 Ki 0.1258 nM
C=CC(=O)N(C)c1cccc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 CHEMBL3651036 IC50 0.13 nM
CN(C)C(=O)C(C#N)=Cc1ccc(-c2nc3cnc4[nH]ccc4c3n2C2CCCCC2)o1 CHEMBL4128181 IC50 0.13 nM
CN(C)C(=O)/C(C#N)=C/c1ccc(-c2nc3cnc4[nH]ccc4c3n2C2CCCCC2)o1 CHEMBL4564280 IC50 0.13 nM
CC(C)COC1CCCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 CHEMBL3652407 IC50 0.132 nM
CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NC(=O)C4=CC(=O)CC4)c3)c12 CHEMBL3651027 IC50 0.14 nM
C=C(C)C(=O)Nc1cc(-c2ncnc3[nH]cc(C(=O)OCC)c23)ccc1C#N CHEMBL3651006 IC50 0.14 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1n1ccc2cnc3[nH]ccc3c21 CHEMBL5281283 IC50 0.14 nM
CC(C)CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ncc3n2)C1 CHEMBL3665158 Ki 0.1491 nM
C=C(C)C(=O)Nc1cc(-c2ncnc3[nH]cc(C(=O)OCC)c23)ccc1C CHEMBL3650992 IC50 0.15 nM
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 CHEMBL3650985 IC50 0.15 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@H]2CCCN(C)C2)c2nc(N)ncc2c1 CHEMBL5086526 pIC50 0.1585 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL221959 Kd 0.16 nM
COC(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)CC1 CHEMBL3665124 Ki 0.1604 nM
N#CCC(N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1)C(F)(F)F CHEMBL3665223 Ki 0.1611 nM
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4cccc(C)c4)c23)c1 CHEMBL3651043 IC50 0.17 nM
Cc1cc2cnc3[nH]ccc3c2n1[C@H]1CN(C(=O)CC#N)CC[C@H]1C CHEMBL5284762 IC50 0.17 nM
COC(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665121 Ki 0.1723 nM
CC(C)C(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665139 Ki 0.1763 nM
C=C(C)C(=O)Nc1cc(C)cc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 CHEMBL3651005 IC50 0.19 nM
C=CC(=O)Nc1cccc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1C CHEMBL3650994 IC50 0.19 nM
CS(=O)(=O)N1C[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C[C@H](C(F)(F)F)C1 CHEMBL3665218 Ki 0.1955 nM
C[C@H]1CN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C[C@@H]1CO CHEMBL3652404 IC50 0.198 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@H]2C[C@H]3CC[C@@H](C2)N3)c2nc(N)ncc2c1 CHEMBL5076189 pIC50 0.1995 nM
O=C(CCl)Nc1cccc(-c2cnc3ccccc3n2)c1 CHEMBL1427221 IC50 0.2 nM
CC1(C#N)CCCC1Nc1c(C(N)=O)cnn2cc(-c3ccccc3)cc12 CHEMBL3671790 IC50 0.2 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccccc4)cc23)CC[C@@]1(C)O CHEMBL3671816 IC50 0.2 nM
CC1(C)CN(c2ccc(C#N)cn2)CC[C@H]1Nc1c(C(N)=O)cnn2cc(N3CC[C@@H](O)C3=O)cc12 CHEMBL3667478 IC50 0.2 nM
CC[C@H]1CN(c2ncc(C#N)s2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC(C)C)c3)cc12 CHEMBL3672473 IC50 0.2 nM
CC(C)NC(=O)c1c[nH]c2ncc(Nc3ccc(/C=C(\C#N)C(=O)N(C)C)cc3)nc12 CHEMBL3910244 IC50 0.2 nM
CN1CCN(C(=O)/C(C#N)=C/c2ccc(Nc3cnc4[nH]cc(C(=O)C(C)(C)C)c4n3)cc2)CC1 CHEMBL3900351 IC50 0.2 nM
CN(C)C(=O)/C(C#N)=C/c1ccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)cc1 CHEMBL3951665 IC50 0.2 nM
CC(C)NC(=O)c1c[nH]c2ncc(Nc3ccc(/C=C(\C#N)C(=O)N4CCNCC4)cc3)nc12 CHEMBL3921536 IC50 0.2 nM
C=CC(=O)Nc1cccc(-c2c[nH]c3ncccc23)c1 CHEMBL5205601 IC50 0.2 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL2103743 Kd 0.2 nM
N#C/C=C/c1ccc(-c2nc3cnc4[nH]ccc4c3n2C2CCCCC2)o1 CHEMBL4128266 IC50 0.21 nM
C=C(Cl)C(=O)Nc1cccc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 CHEMBL3651018 IC50 0.22 nM
CN(C)c1ncc(-c2cnc3[nH]cc(C#N)c3n2)c(N[C@H]2CCCN(S(C)(=O)=O)C2)n1 CHEMBL3665187 Ki 0.2242 nM
CCCS(=O)(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665134 Ki 0.2781 nM
CC(C)CCS(=O)(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665143 Ki 0.2805 nM
C[C@@H](NC(=O)c1c[nH]c2ncc(-c3ncn4cc(F)ccc34)nc12)C(=O)N1CC(C#N)C1 CHEMBL2376157 IC50 0.3 nM
Cn1nc(-c2cnc3[nH]cc(C(=O)N[C@@H](C(=O)N4CC(C#N)C4)C4CC4)c3n2)c2ccc(Cl)cc21 CHEMBL2376154 IC50 0.3 nM
N#Cc1ccc(N2CC[C@@H](Nc3c(C(N)=O)cnc4[nH]ccc34)[C@@H](F)C2)nc1 CHEMBL3593777 IC50 0.3 nM
O=C(CBr)Nc1cccc(-c2cnc3ccccc3n2)c1 CHEMBL3648430 IC50 0.3 nM
Cc1cccc(-c2cc3c(N[C@@H]4CCC[C@]4(C)F)c(C(N)=O)cnn3c2)c1 CHEMBL3666889 IC50 0.3 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(CO)cc4)cc23)CC[C@]1(C)N CHEMBL3671811 IC50 0.3 nM
COc1ccc(-c2cc3c(N[C@@H]4CC[C@](C)(C(N)=O)C4(C)C)c(C(N)=O)cnn3c2)cn1 CHEMBL3671829 IC50 0.3 nM
CC[C@H]1CN(c2ncc(C#N)s2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)cc12 CHEMBL3672472 IC50 0.3 nM
CC[C@H]1CN(C(=O)C2(C#N)CCC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccnc(Cl)c3)cc12 CHEMBL3672462 IC50 0.3 nM
C=CC(=O)Nc1cccc(-c2ncnc3[nH]ccc23)c1 CHEMBL4085582 IC50 0.3 nM
C=CC(=O)N1C[C@H](Nc2ncnc3[nH]ccc23)CC[C@@H]1C CHEMBL4085457 IC50 0.3 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(B(O)O)cc3)ncc2C(F)(F)F)c1 CHEMBL4640647 IC50 0.3 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC(C)(O)C2)CC1 CHEMBL3652406 IC50 0.302 nM
CC(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)CC1 CHEMBL3665125 Ki 0.3103 nM
COc1cc(-c2ccc(O)cc2)cc2cnc(Nc3cnn(C)c3)nc12 CHEMBL5084861 pIC50 0.3162 nM
C=C(C)C(=O)n1ccc2ccc(-c3ncnc4[nH]cc(C(=O)OCC)c34)cc21 CHEMBL3651002 IC50 0.34 nM
CCCC(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665138 Ki 0.3592 nM
Cc1nccc(Nc2cc(NC3CCN(c4ccc(C#N)cn4)CC3)c(C(N)=O)cn2)n1 CHEMBL4591633 IC50 0.36 nM
CC(C)CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3ccn(C)c3n2)C1 CHEMBL3665161 Ki 0.3859 nM
N#CC(C#N)=Cc1ccc(-c2nc3cnc4[nH]ccc4c3n2C2CCCCC2)o1 CHEMBL4125719 IC50 0.39 nM
Cc1nccc(Nc2cc(N[C@@H]3CCN(c4ccc(C#N)cn4)C[C@@H]3F)c(C(N)=O)cn2)n1 CHEMBL4466236 IC50 0.39 nM
CC(C)S(=O)(=O)N1CCC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665132 Ki 0.3997 nM
COc1cc(-c2cnc3[nH]cc(C(=O)N[C@H](C)C(=O)N4CC(C#N)C4)c3n2)cc(OC)c1OC CHEMBL2376040 IC50 0.4 nM
C=C(C)C(=O)Nc1cc(-c2ncnc3[nH]cc(C(=O)OC)c23)ccc1F CHEMBL3651034 IC50 0.4 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccccc4)cc23)CC[C@]1(C)C(N)=O CHEMBL3671828 IC50 0.4 nM
C[C@@H]1[C@H]2CN(C(=O)CO)C[C@H]2C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccc(C(N)=O)cc3)cc12 CHEMBL3667469 IC50 0.4 nM
C[C@@H]1[C@H]2CN(S(C)(=O)=O)C[C@H]2C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3nnn(C)n3)cc12 CHEMBL3667472 IC50 0.4 nM
C[C@@H]1[C@H]2CN(C(=O)CO)C[C@H]2C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccc(C(=O)NC4CC4)cc3)cc12 CHEMBL3667474 IC50 0.4 nM
CC(=O)N1C[C@H]2C[C@@H](Nc3c(C(N)=O)cnn4cc(-c5cnn(C)c5)cc34)[C@H](C)[C@H]2C1 CHEMBL3667476 IC50 0.4 nM
CC[C@H]1CN(c2ccc(C#N)cn2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccc(=O)n(C)c3)cc12 CHEMBL3672451 IC50 0.4 nM
C[C@H]1CN(c2ccc(C#N)cn2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC(=O)N4CC(F)(F)C4)c3)cc12 CHEMBL3672453 IC50 0.4 nM
CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(/C=C(/C#N)C(N)=O)cc3)nc12 CHEMBL4114664 IC50 0.4 nM
CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(/C=C(\C#N)C(=O)N4CCC4)cc3)nc12 CHEMBL3976465 IC50 0.4 nM
C=CC(=O)N1CC[C@H]2CCN(c3ncnc4[nH]ccc34)[C@H]2C1 CHEMBL4064018 IC50 0.4 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(F)nc4)cc23)CC[C@]1(C)N CHEMBL4098840 IC50 0.4 nM
COc1cccc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)c1 CHEMBL4076794 IC50 0.4 nM
O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c1cc(N2CCN(C(=O)CCl)CC2)ccc1C(F)(F)F CHEMBL4463109 IC50 0.4 nM
C=CC(=O)NCCCN(C)c1ccc([N+](=O)[O-])c(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c1 CHEMBL4464668 IC50 0.4 nM
C=CC(=O)N1CCN(c2ccc([N+](=O)[O-])c(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c2)CC1 CHEMBL4450627 IC50 0.4 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc4c(c3)COB4O)ncc2C(F)(F)F)c1 CHEMBL4642642 IC50 0.4 nM
CC(C)S(=O)(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665135 Ki 0.413 nM
CSc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(C(=O)CC#N)C2)n1 CHEMBL3665194 Ki 0.4222 nM
C=CC(=O)Nc1ccc(F)c(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 CHEMBL4209692 IC50 0.43 nM
NC(=O)c1cnc2[nH]ccc2c1NC1C2CC3CC1CC(O)(C3)C2 CHEMBL4238926 IC50 0.43 nM
N#C[C@H]1CCN(C(=O)[C@H](NC(=O)c2c[nH]c3ncc(C4CC4)nc23)C2CC2)C1 CHEMBL2325898 IC50 0.44 nM
N#Cc1ccc(N2CCC(Nc3cc(Nc4ccccn4)ncc3C(N)=O)CC2)nc1 CHEMBL4455068 IC50 0.46 nM
C=C(C)C(=O)Nc1cc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c[nH]c1=O CHEMBL3651012 IC50 0.47 nM
CC(C)(O)C(=O)N1CCN(c2ccc(C(F)(F)F)c(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c2)CC1 CHEMBL1650951 IC50 0.5 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(CC(=O)NCC(F)(F)F)c3)ncc2Cl)c1 CHEMBL3601110 IC50 0.5 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)c3ccsn3)C4)n[nH]c2c1 CHEMBL3644619 IC50 0.5 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)c3cnc(N5CCCCC5)cn3)C4)n[nH]c2c1 CHEMBL3644620 IC50 0.5 nM
C[C@]1(F)CCC[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cccc(C(N)=O)c3)cc12 CHEMBL3666890 IC50 0.5 nM
C[C@]1(F)CCC[C@H]1Nc1c(C(N)=O)cnn2cc(N3CCCC3=O)cc12 CHEMBL3671794 IC50 0.5 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4cccnc4)cc23)CC[C@]1(C)N CHEMBL3671804 IC50 0.5 nM
CC1(C)CCC[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccccc3)cc12 CHEMBL3671819 IC50 0.5 nM
CNC(=O)Cn1cc(-c2cc3c(N[C@@H]4CN(c5ccc(Cl)cn5)C[C@@H]4C)c(C(N)=O)cnn3c2)cn1 CHEMBL3672474 IC50 0.5 nM
CC[C@H]1CN(S(C)(=O)=O)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC(C)C)c3)cc12 CHEMBL3672460 IC50 0.5 nM
CC[C@H]1CN(C(=O)OC(C)(C)C)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cc(C)no3)cc12 CHEMBL3672465 IC50 0.5 nM
CN(C)C(=O)/C(C#N)=C/c1ccc(Nc2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)c(F)c1 CHEMBL3960370 IC50 0.5 nM
CC[C@@H]1CN(c2ccc(C#N)cn2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)nc12 CHEMBL3914152 IC50 0.5 nM
Cn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CCN(c5ccc(C#N)nn5)CC4(C)C)c3n2)cn1 CHEMBL3905150 IC50 0.5 nM
CC[C@@H]1CN(c2ccc(C#N)nn2)CC[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC)c3)nc12 CHEMBL3975940 IC50 0.5 nM
CC[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cn[nH]c3)nc12 CHEMBL3935662 IC50 0.5 nM
CC(C)Oc1ccc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)cn1 CHEMBL4070136 IC50 0.5 nM
C=CC(=O)Nc1cccc(-c2ncnc3[nH]cc(CCOC)c23)c1 CHEMBL4288086 IC50 0.5 nM
C=CC(=O)N1CCOc2ccc(-c3ncnc4[nH]cc(CCOC)c34)cc21 CHEMBL4280180 IC50 0.5 nM
N#CN[C@H]1CCc2ccc(-c3ncnc4[nH]cc(-c5cccc(CO)c5)c34)cc21 CHEMBL4292341 IC50 0.5 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc4c(c3)B(O)OC4)ncc2C(F)(F)F)c1 CHEMBL4648837 IC50 0.5 nM
CC[C@H]1CN(c2ccc(C#N)cn2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)nc12 CHEMBL5285673 IC50 0.5 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@@H](C)CO)c2nc(NCCCCCN(C)C)ncc2c1 CHEMBL5075556 pIC50 0.5012 nM
CCCS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3cc[nH]c3n2)C1 CHEMBL3665159 Ki 0.5293 nM
CN(C(=O)CC#N)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3955948 IC50 0.55 nM
CN(C(=O)Nc1ccc(C#N)cc1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3960213 IC50 0.55 nM
CN(C(=O)CC(F)(F)F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3910875 IC50 0.55 nM
C=CCN(C1CCCC1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3955757 IC50 0.55 nM
N#Cc1ccc(N(C2CC2)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)nc1 CHEMBL3984764 IC50 0.55 nM
CCS(=O)(=O)N(C)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3954558 IC50 0.55 nM
CN(c1ccc(C#N)nn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3926930 IC50 0.55 nM
CN(c1ccc(C(F)(F)F)nn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3925768 IC50 0.55 nM
CN(CCC#N)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3913220 IC50 0.55 nM
CN(c1ccc([N+](=O)[O-])cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3952191 IC50 0.55 nM
CN(c1ccc(C#N)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3896481 IC50 0.55 nM
Cc1cc(Cl)nc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)c1C#N CHEMBL3973848 IC50 0.55 nM
Cc1cc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)ncc1[N+](=O)[O-] CHEMBL3890701 IC50 0.55 nM
CN(c1nc(Cl)nc2ccccc12)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3949963 IC50 0.55 nM
CN(c1ncnc2ccccc12)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3952555 IC50 0.55 nM
N#Cc1ccc(NC2CCN(c3ncnc4[nH]ccc34)C2)nc1 CHEMBL3968548 IC50 0.55 nM
CN(c1cnc(C#N)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3937204 IC50 0.55 nM
COc1cc2ncnc(N(C)[C@@H]3CCN(c4ncnc5[nH]ccc45)C3)c2cc1OC CHEMBL3897417 IC50 0.55 nM
CN(c1nc(Cl)c(C#N)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3930750 IC50 0.55 nM
CN(c1cccc(C#N)n1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3961850 IC50 0.55 nM
CN(C1NC(C#N)=CS1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3903286 IC50 0.55 nM
CN(c1ncc(Br)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3919799 IC50 0.55 nM
CN(c1ncc(C#N)cc1[N+](=O)[O-])[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3925815 IC50 0.55 nM
N#Cc1cnc(NC2CCN(c3ncnc4[nH]ccc34)C2)c([N+](=O)[O-])c1 CHEMBL3975440 IC50 0.55 nM
CCCN(c1ccc(C#N)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3940099 IC50 0.55 nM
CN(c1ncc(C#N)cc1Br)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3906885 IC50 0.55 nM
CN(c1ccc(C#N)cn1)[C@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3977509 IC50 0.55 nM
CN(c1ccc(C#N)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3915857 IC50 0.55 nM
CN(c1ccc(C#N)cc1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3899672 IC50 0.55 nM
CN(c1ccc(C#N)cc1[N+](=O)[O-])[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3980318 IC50 0.55 nM
CN(c1ccc(C#N)c2ccccc12)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3982307 IC50 0.55 nM
CN(c1ccc(C#N)c(Br)c1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3921320 IC50 0.55 nM
C#CCN(c1ccc(C#N)cc1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3905748 IC50 0.55 nM
CN(c1cncc(-n2ccnc2)n1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3914739 IC50 0.55 nM
CN(c1ccccn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3920581 IC50 0.55 nM
CN(c1ncccc1C#N)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3926059 IC50 0.55 nM
CN(c1ccc2nc[nH]c2n1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3934942 IC50 0.55 nM
CN(c1ccc2[nH]c(=O)[nH]c2n1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3962448 IC50 0.55 nM
COC(=O)c1ccc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)nc1 CHEMBL3976708 IC50 0.55 nM
CN(c1ccc(C(=O)NC2CC2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3902542 IC50 0.55 nM
CN(c1ccc(C(=O)N[C@H](CO)c2ccccc2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3984793 IC50 0.55 nM
CN(c1ccc(C(=O)N[C@@H](CO)c2ccccc2)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3977452 IC50 0.55 nM
CN(c1ccc(C(=O)NC2c3ccccc3CC2O)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3939312 IC50 0.55 nM
CN(c1ccc(C(=O)NCc2ccccc2)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3933796 IC50 0.55 nM
CN(c1ccc(C(=O)NCCO)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3902351 IC50 0.55 nM
CN(c1ccc(C(=O)NC(CO)c2ccc(Cl)cc2)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3896837 IC50 0.55 nM
CN(c1ccc(C(=O)NC[C@H](O)c2ccccc2)cc1F)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1 CHEMBL3914438 IC50 0.55 nM
CCS(=O)(=O)Nc1ccc(N(C)[C@@H]2CCN(c3ncnc4[nH]ccc34)C2)nc1 CHEMBL3982255 IC50 0.55 nM
CC(C)CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3cc[nH]c3n2)C1 CHEMBL3665168 Ki 0.5656 nM
C=CC(=O)Nc1ccc(CNc2nc(Nc3cnn(C)c3)ncc2Cl)cc1 CHEMBL3601706 IC50 0.58 nM
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4cccc(F)c4)c23)c1 CHEMBL3651044 IC50 0.59 nM
CC(C)CS(=O)(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 CHEMBL3665136 Ki 0.5933 nM
O=c1[nH]ccc2c3[nH]c(-c4c(F)cccc4Cl)nc3c3ccc(F)cc3c12 CHEMBL272424 IC50 0.6 nM
C[C@@H](NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(F)ccc34)nc12)C(=O)N1CC(C#N)C1 CHEMBL2376147 IC50 0.6 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(C)c3)ncc2Cl)c1 CHEMBL3601242 IC50 0.6 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(CC(=O)N4CCOCC4)c3)ncc2Cl)c1 CHEMBL3601112 IC50 0.6 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(C(C)(C)COC)c3)ncc2Cl)c1 CHEMBL3601119 IC50 0.6 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(CC(C)(C)O)c3)ncc2Cl)c1 CHEMBL3601121 IC50 0.6 nM
CS(=O)(=O)OCC(=O)Nc1cccc(-c2cnc3ccccc3n2)c1 CHEMBL3648433 IC50 0.6 nM
C[C@@H]1[C@H]2CN(S(C)(=O)=O)C[C@H]2C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnc(N)nc3)cc12 CHEMBL3667467 IC50 0.6 nM
C[C@H]1CN(c2ccc(C#N)cn2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC(=O)N4CCC(F)(F)C4)c3)cc12 CHEMBL3672454 IC50 0.6 nM
CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(/C=C(/C#N)S(C)(=O)=O)cc3)nc12 CHEMBL3955783 IC50 0.6 nM
CCCn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(c5ncc(C#N)cn5)C[C@H]4C)c3n2)cn1 CHEMBL3965169 IC50 0.6 nM
CC[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)nc12 CHEMBL3963792 IC50 0.6 nM
CC[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3c(C)nn(C)c3C)nc12 CHEMBL3905704 IC50 0.6 nM
CCn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CCN(c5ccc(C#N)nn5)CC4(C)C)c3n2)cn1 CHEMBL3980778 IC50 0.6 nM
CC[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)nc12 CHEMBL3952907 IC50 0.6 nM
Cc1cc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)ccn1 CHEMBL4073562 IC50 0.6 nM
C=CC(=O)NCCN(C)c1ccc(C(F)(F)F)c(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c1 CHEMBL4454565 IC50 0.6 nM
C=CC(=O)NCCCN(C)c1ccc(C(F)(F)F)c(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c1 CHEMBL4578121 IC50 0.6 nM
C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCOCC4)cc3)nc3[nH]cc(-c4ccncc4)c23)c1 CHEMBL4464404 IC50 0.6 nM
C=C(CC)C(=O)Nc1cccc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 CHEMBL3650990 IC50 0.61 nM
N#Cc1ccc(N2CCC(Nc3cc(Nc4ccncn4)ncc3C(N)=O)CC2)nc1 CHEMBL4463043 IC50 0.61 nM
COC12CC3CC(C1)C(Nc1c(C(N)=O)cnc4[nH]ccc14)C(C3)C2 CHEMBL4246788 IC50 0.63 nM
Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCC#N)c4c21)CNC3=O CHEMBL302449 pKi 0.631 nM
C=C(CN1CCOCC1)C(=O)Nc1cccc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 CHEMBL3651029 IC50 0.66 nM
C=C(C)C(=O)Nc1cc(-c2ncnc3[nH]cc(C(=O)OCC)c23)cnc1OC CHEMBL3651011 IC50 0.68 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OC)c(OCCCN4CCOCC4)c3)ncc2Cl)c1 CHEMBL4289281 IC50 0.69 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(C4CCOCC4)c3)ncc2Cl)c1 CHEMBL3601108 IC50 0.7 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(CCOC(F)F)c3)ncc2Cl)c1 CHEMBL3601118 IC50 0.7 nM
C=CC(=O)Nc1cccc(CN(C)c2nc(Nc3cnn(C)c3)ncc2Cl)c1 CHEMBL3601713 IC50 0.7 nM
C=CC(=O)Nc1cccc(Cn2ccc3cnc(Nc4ccc(N5CCN(C)CC5)cc4)nc32)c1 CHEMBL3601723 IC50 0.7 nM
CNC(=O)c1ccc(-c2cc3c(N[C@@H]4C[C@@H]5CN(C(=O)C(C)(C)O)C[C@@H]5[C@H]4C)c(C(N)=O)cnn3c2)cn1 CHEMBL3667471 IC50 0.7 nM
CN(C)C(=O)/C(C#N)=C/c1ccc(Nc2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)cc1F CHEMBL3967948 IC50 0.7 nM
CC(C)NC(=O)c1c[nH]c2ncc(Nc3ccc(/C=C(\C#N)C(=O)N4CCOCC4)cc3)nc12 CHEMBL3973173 IC50 0.7 nM
CCCn1cc(-c2cn3ncc(C(N)=O)c(N[C@@H]4CN(C(=O)C5(C#N)CC5)C[C@@H]4C)c3n2)cn1 CHEMBL3942856 IC50 0.7 nM
CC[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cn(C)nc3C)nc12 CHEMBL3896771 IC50 0.7 nM
CCCn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(C(=O)C5(C#N)CC5)C[C@H]4CC)c3n2)cn1 CHEMBL3949368 IC50 0.7 nM
C=CC(=O)N1CCC[C@@H](Nc2ncnc3[nH]ccc23)C1 CHEMBL4062946 IC50 0.7 nM
Cc1ccc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)cc1 CHEMBL4060536 IC50 0.7 nM
C[C@]1(NC#N)CCc2ccc(-c3ncnc4[nH]ccc34)cc21 CHEMBL4279720 IC50 0.7 nM
N#CN[C@H]1CCc2ccc(-c3ncnc4[nH]cc(-c5ccccc5)c34)cc21 CHEMBL4287845 IC50 0.7 nM
N#CC[C@H]1CC[C@H](n2c(=O)[nH]c3cnc(Nc4cc(Cl)c[nH]c4=O)nc32)CC1 CHEMBL4526485 IC50 0.7 nM
NC(=O)c1cnc2[nH]ccc2c1N[C@@H]1[C@@H]2CC3C[C@H]1C[C@@](O)(C3)C2 CHEMBL3137308 IC50 0.7 nM
NC(=O)c1cnc2[nH]ccc2c1NC1[C@@H]2CC3C[C@H]1CC(O)(C3)C2 CHEMBL5424861 IC50 0.7 nM
NC(=O)c1cnc2[nH]ccc2c1NC1C2CC3CC1CC(O)(C3)C2 CHEMBL4242999 IC50 0.71 nM
N#Cc1ccc(N2CCC(Nc3cc(Nc4cnccn4)ncc3C(N)=O)CC2)nc1 CHEMBL4454640 IC50 0.72 nM
CN1CCN(C(=O)C(C#N)=Cc2ccc(-c3nc4cnc5[nH]ccc5c4n3C3CCCCC3)o2)CC1 CHEMBL4125861 IC50 0.74 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@@H](OP(=O)(O)O)C2)CC1 CHEMBL3652410 IC50 0.768 nM
N#C/C(=C/c1cccc(-c2ncnc3[nH]ccc23)c1)C(N)=O CHEMBL5278864 IC50 0.77 nM
CC(Br)C(=O)Nc1cccc(-c2ncnc3[nH]ccc23)c1 CHEMBL5272677 IC50 0.77 nM
O=C(CCl)Nc1cccc(-c2ncnc3[nH]ccc23)c1 CHEMBL5270127 IC50 0.77 nM
C[C@H]1CN(c2ccc(C#N)cn2)CC[C@H]1Nc1c(C(N)=O)cnc2[nH]ccc12 CHEMBL3593779 IC50 0.78 nM
CCc1cc(O)c(F)cc1-c1cc(NC2CCN(C(C)=O)CC2)c2nc(N)ncc2c1 CHEMBL5084542 pIC50 0.7943 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@@H](C)CO)c2nc(N)ncc2c1 CHEMBL5078647 pIC50 0.7943 nM
Cn1nc(-c2cnc3[nH]cc(C(=O)N[C@@H](C(=O)N4CC(C#N)C4)C(C)(C)C)c3n2)c2ccc(Cl)cc21 CHEMBL2376155 IC50 0.8 nM
C[C@@H](NC(=O)c1c[nH]c2ncc(-c3cn(C)c4cc(Cl)ccc34)nc12)C(=O)N1CC(C#N)C1 CHEMBL2376143 IC50 0.8 nM
CS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL3645121 IC50 0.8 nM
CN(C)C(=O)c1ccc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)cc1 CHEMBL3671810 IC50 0.8 nM
Cc1nn(C)cc1-c1cn2ncc(C(N)=O)c(N[C@H]3CN(C(=O)C4(C#N)CC4)C[C@H]3C)c2n1 CHEMBL3939580 IC50 0.8 nM
CC[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C[C@H](C)O)c3)nc12 CHEMBL3938736 IC50 0.8 nM
CC[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C[C@@H](C)O)c3)nc12 CHEMBL3890933 IC50 0.8 nM
CCc1cc(O)ccc1-c1ccc2c(-c3ncc[nH]3)n[nH]c2c1 CHEMBL4086057 IC50 0.8 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(Cl)cc4)cc23)CC[C@]1(C)N CHEMBL4062062 IC50 0.8 nM
C#CC(=O)N1CCN(c2ccc(C(F)(F)F)c(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c2)CC1 CHEMBL4543011 IC50 0.8 nM
Cc1nccc(Nc2cc(NC3CCN(c4ccc(C#N)cc4)CC3)c(C(N)=O)cn2)n1 CHEMBL4463436 IC50 0.8 nM
C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc4c(c3)COB4O)ncc2OC)c1 CHEMBL4649397 IC50 0.8 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCCN4CCOCC4)cc3)ncc2Cl)c1 CHEMBL4290692 IC50 0.83 nM
C=CC(=O)Nc1ccc(CNc2nc(Nc3ccc(N4CCOCC4)cc3)ncc2Cl)cc1 CHEMBL3601705 IC50 0.87 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1n1cnc2cnc3[nH]ccc3c21 CHEMBL2152297 Ki 0.9 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3ccc(N4CCN(C)CC4)c(F)c3)ncc2Cl)c1 CHEMBL3601227 IC50 0.9 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3ccc(N4CCOCC4)c(F)c3)ncc2Cl)c1 CHEMBL3601233 IC50 0.9 nM
C=CC(=O)Nc1cccc(CN2C(=O)NCc3cnc(Nc4ccc(N5CCN(C)CC5)cc4)nc32)c1 CHEMBL3601726 IC50 0.9 nM
CC(=O)Nc1cc2c(N[C@@H]3CC[C@@](C)(O)C3(C)C)c(C(N)=O)cnn2c1 CHEMBL3666882 IC50 0.9 nM
COc1ccc(-c2cc3c(N[C@@H]4CCN(C(=O)C(N)=O)CC4(C)C)c(C(N)=O)cnn3c2)cn1 CHEMBL3667466 IC50 0.9 nM
CN(C)C(=O)/C(C#N)=C/c1ccc(Nc2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)cn1 CHEMBL3977489 IC50 0.9 nM
CC(C)n1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(c5ncc(C#N)cn5)C[C@H]4C)c3n2)cn1 CHEMBL3903685 IC50 0.9 nM
C[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C4CC4)c3)nc12 CHEMBL3956402 IC50 0.9 nM
CC[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C4CC4)c3)nc12 CHEMBL3963248 IC50 0.9 nM
COc1ccc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)cn1 CHEMBL4080797 IC50 0.9 nM
Cc1ccc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)cn1 CHEMBL4060444 IC50 0.9 nM
Cc1cccc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)c1 CHEMBL4087655 IC50 0.9 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccccc4)cc23)CC[C@]1(C)N CHEMBL4096145 IC50 0.9 nM
CS(=O)(=O)N[C@@H]1C[C@H](NC#N)c2cc(-c3ncnc4[nH]ccc34)ccc21 CHEMBL4292320 IC50 0.9 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCCN4CCN(CC)CC4)c(Cl)c3)ncc2Cl)c1 CHEMBL4294772 IC50 0.91 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OC)c(OCCCN4CCOCC4)c3)ncc2F)c1 CHEMBL4290449 IC50 0.95 nM
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4ccccc4F)c23)c1 CHEMBL3651045 IC50 0.96 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 IC50 1.0 nM
COC(=O)[C@]1(O)Cn2c3ccccc3c3c4c(c5c6ccccc6n(c5c32)C[C@H]1O)C(=O)NC4=O CHEMBL564940 IC50 1.0 nM
N#Cc1ccc2ncn(-c3ncc4[nH]c(=O)n([C@@H]5CCOc6c(F)cccc65)c4n3)c2c1 CHEMBL1079594 IC50 1.0 nM
C[C@@H](NC(=O)c1c[nH]c2ncc(-c3ncn4cc(F)cc(F)c34)nc12)C(=O)N1CC(C#N)C1 CHEMBL2376158 IC50 1.0 nM
C[C@]1(F)CCC[C@H]1Nc1c(C(N)=O)cnn2cccc12 CHEMBL3359927 IC50 1.0 nM
CC(C)CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3nc[nH]c3n2)C1 CHEMBL3665163 IC50 1.0 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)c3ccsn3)CC4)n[nH]c2c1 CHEMBL3644625 IC50 1.0 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)c3ccc(Cl)cn3)C4)n[nH]c2c1 CHEMBL3644628 IC50 1.0 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccccc4)cc23)CC[C@]1(C)NS(C)(=O)=O CHEMBL3671791 IC50 1.0 nM
COc1ccccc1-c1cc2c(NC3C4CC5CC3CC(O)(C5)C4)c(C(N)=O)cnn2c1 CHEMBL3671801 IC50 1.0 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(C#N)nc4)cc23)CC[C@]1(C)C(N)=O CHEMBL3671831 IC50 1.0 nM
C[C@@H]1[C@H]2CN(C(=O)C(C)(C)O)C[C@H]2C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnc(N)nc3)cc12 CHEMBL3667470 IC50 1.0 nM
CN(C)C(=O)/C(C#N)=C/c1ccc(Nc2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)cc1 CHEMBL3890245 IC50 1.0 nM
CN(C)C(=O)/C(C#N)=C/c1ccc(Nc2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)cc1Cl CHEMBL3891319 IC50 1.0 nM
CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(/C=C(\C#N)C(=O)N4CCCCC4)cc3)nc12 CHEMBL3956776 IC50 1.0 nM
CCNC(=O)/C(C#N)=C/c1ccc(Nc2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)cc1 CHEMBL3934694 IC50 1.0 nM
CCn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(c5ccc(C#N)cn5)C[C@H]4C)c3n2)cn1 CHEMBL3900587 IC50 1.0 nM
C[C@H](O)Cn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(c5ncc(C#N)cn5)C[C@H]4C)c3n2)cn1 CHEMBL3922873 IC50 1.0 nM
C[C@@H]1CN(c2ccc(C#N)cn2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C[C@@H](C)O)c3)nc12 CHEMBL3914278 IC50 1.0 nM
CCCn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(c5ccc(C#N)cn5)C[C@H]4C)c3n2)cn1 CHEMBL3937711 IC50 1.0 nM
CC[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC)c3)nc12 CHEMBL3896264 IC50 1.0 nM
CC[C@@H]1CN(C(=O)C2(C#N)CCC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)nc12 CHEMBL4115596 IC50 1.0 nM
CC[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3ccc4c(cnn4C)c3)nc12 CHEMBL3973287 IC50 1.0 nM
CC[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3ccn(C)n3)nc12 CHEMBL3922444 IC50 1.0 nM
CC[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C(C)C)c3)nc12 CHEMBL3936210 IC50 1.0 nM
N#CC1(C(=O)N2C[C@H](CF)[C@H](Nc3c(C(N)=O)cnn4cc(-c5ccc6c(c5)NC(=O)C6)nc34)C2)CC1 CHEMBL3982270 IC50 1.0 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(C#N)nc4)cc23)CC[C@]1(C)N CHEMBL4096795 IC50 1.0 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(C#N)cc4)cc23)CC[C@]1(C)N CHEMBL4091582 IC50 1.0 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4cccc(Cl)c4)cc23)CC[C@]1(C)N CHEMBL4076823 IC50 1.0 nM
CC1(NC#N)CCc2ccc(-c3ncnc4[nH]ccc34)cc21 CHEMBL4293778 IC50 1.0 nM
N#CN[C@H]1C[C@@H](O)c2ccc(-c3ncnc4[nH]ccc34)cc21 CHEMBL4294868 IC50 1.0 nM
COCCS(=O)(=O)N[C@@H]1C[C@H](NC#N)c2cc(-c3ncnc4[nH]ccc34)ccc21 CHEMBL4288935 IC50 1.0 nM
C=CC(=O)N1CCN(c2ccc(C(F)(F)F)c(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c2)CC1 CHEMBL4435664 Ki 1.0 nM
COc1ccc(-c2cc3c(N[C@H](CO)CC4CC4)c(C(N)=O)cnn3c2)cn1 CHEMBL4549451 IC50 1.0 nM
O=c1[nH]c2cnc(-c3cnc4ccc(F)cn34)nc2n1[C@@H]1CC[C@@H](O)c2ccccc21 CHEMBL4471599 IC50 1.0 nM
Cc1cncc(Nc2cc(NC3CCN(c4ccc(C#N)cn4)CC3)c(C(N)=O)cn2)n1 CHEMBL4470355 IC50 1.0 nM
CCC(=O)N1CCC(c2ccc(Nc3cc(NCc4cccc(-c5ccncc5)c4)c(C(N)=O)cn3)cc2)CC1 CHEMBL4584430 IC50 1.0 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc4c(c3)B(O)OC4(C)C)ncc2C(F)(F)F)c1 CHEMBL4645290 IC50 1.0 nM
OCCn1cc(Nc2ncc(Cl)c(NCc3cc(F)ccc3F)n2)cn1 CHEMBL4635876 pIC50 1.0 nM
COC[C@H](C)OC(=O)Cc1ccc(Nc2cc(Nc3ccccc3OC)c(C(N)=O)cn2)nc1 CHEMBL5412967 IC50 1.0 nM
NC(=O)c1nnc(-c2c(F)cccc2F)cc1Nc1ccc(N2CCOCC2)cn1 CHEMBL5420928 IC50 1.0 nM
COc1cc2c(=O)n(C3CCCCCCC3)c3c4cc[nH]c4ncc3c2cc1OC CHEMBL4281080 IC50 1.01 nM
CCCS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3ccn(C)c3n2)C1 CHEMBL3665160 Ki 1.026 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCCN4CCOCC4)c(Cl)c3)ncc2Cl)c1 CHEMBL4284156 IC50 1.06 nM
COc1cc2c(=O)n(C3CCCCCC3)c3c4cc[nH]c4ncc3c2cc1OC CHEMBL4291720 IC50 1.09 nM
C[C@@H](NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(Cl)ccc34)nc12)C(=O)N1CC(C#N)C1 CHEMBL2376144 IC50 1.1 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1n1c(=O)[nH]c2cnc3[nH]ccc3c21 CHEMBL3593591 IC50 1.1 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(CC(=O)N(C)C)c3)ncc2Cl)c1 CHEMBL3601111 IC50 1.1 nM
C=C(C)C(=O)Nc1cc(-c2ncnc3[nH]cc(C(=O)OCC)c23)cn(C)c1=O CHEMBL3651013 IC50 1.1 nM
C[C@@H]1CN(c2ccc(C#N)cn2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC(C)(C)O)c3)nc12 CHEMBL3973511 IC50 1.1 nM
C[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3ccc4c(cnn4C)c3)nc12 CHEMBL3951604 IC50 1.1 nM
CC[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccc4ncccc4c3)nc12 CHEMBL3890332 IC50 1.1 nM
CC[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3sc(C)nc3C)nc12 CHEMBL3980209 IC50 1.1 nM
CCOc1ccc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)cn1 CHEMBL4091096 IC50 1.1 nM
O=c1[nH]cc(F)cc1Nc1ncc2[nH]c(=O)n([C@@H]3CCOc4c(F)cccc43)c2n1 CHEMBL4526498 IC50 1.1 nM
O=c1[nH]cc(Cl)cc1Nc1ncc2[nH]c(=O)n([C@@H]3CCOc4c(F)cccc43)c2n1 CHEMBL4482927 IC50 1.1 nM
Cc1cnc(Nc2cc(NC3CCN(c4ccc(C#N)cn4)CC3)c(C(N)=O)cn2)cn1 CHEMBL4471707 IC50 1.1 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1n1cc(C#N)c2cnc3[nH]ccc3c21 CHEMBL5267452 IC50 1.1 nM
CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3nc[nH]c3n2)C1 CHEMBL3665155 Ki 1.185 nM
CC[C@@](C)(Nc1ccnc(-c2c[nH]c3ncccc23)n1)C(=O)NCC(F)(F)F CHEMBL3039513 IC50 1.2 nM
N#Cc1ccc(N2CCC(Nc3c(C(N)=O)cnc4[nH]ccc34)CC2)nn1 CHEMBL3593776 IC50 1.2 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3ccc(N4CCN(C)CC4)cc3)ncc2Cl)c1 CHEMBL3601226 IC50 1.2 nM
C=CC(=O)Nc1cccc(CSc2nc(Nc3cnn(C)c3)ncc2Cl)c1 CHEMBL3601712 IC50 1.2 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(Cc3cnc5ccccc5c3)C4)n[nH]c2c1 CHEMBL3644636 IC50 1.2 nM
C[C@@H]1CN(c2ncc(C#N)cn2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C[C@@H](C)O)c3)nc12 CHEMBL3945733 IC50 1.2 nM
C[C@H](O)Cn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(c5ccc(C#N)cn5)C[C@H]4C)c3n2)cn1 CHEMBL3899852 IC50 1.2 nM
Cc1nn(C)cc1-c1cn2ncc(C(N)=O)c(N[C@H]3CN(c4ncc(C#N)cn4)C[C@H]3C)c2n1 CHEMBL3949959 IC50 1.2 nM
C[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C[C@@H](O)C(F)(F)F)c3)nc12 CHEMBL3957930 IC50 1.2 nM
CC[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC(C)(C)O)c3)nc12 CHEMBL3913520 IC50 1.2 nM
C=CC(=O)N1CCC[C@@H](Oc2nc(Nc3ccc(N4CCN(CC)CC4)cc3)nc3[nH]cc(-c4cncc(NC)n4)c23)C1 CHEMBL4457018 IC50 1.2 nM
C=CC(=O)Nc1cccc(Nc2ncc(Cl)c(O[C@@H]3CO[C@H]4[C@@H]3OC[C@H]4O)n2)c1 CHEMBL5189603 IC50 1.2 nM
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(O[C@@H]3CO[C@H]4[C@@H]3OC[C@H]4OC)n2)ccc1N(C)CCN(C)C CHEMBL5193702 IC50 1.2 nM
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(O[C@@H]3CO[C@H]4[C@@H]3OCC4(F)F)n2)ccc1N(C)CCN(C)C CHEMBL5192736 IC50 1.2 nM
CCc1cc(O)c(F)cc1-c1cc(NC[C@H](C)O)c2nc(N)ncc2c1 CHEMBL5078141 pIC50 1.259 nM
CN1CCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)CC1 CHEMBL3652405 IC50 1.29 nM
N#Cc1ccc(N2CCC(Nc3c(C(N)=O)cnc4[nH]ccc34)CC2)nc1 CHEMBL3593771 IC50 1.3 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3ccc(N4CCOCC4)cc3)ncc2Cl)c1 CHEMBL3601231 IC50 1.3 nM
C=CC(=O)Nc1ccc(CNc2nc(Nc3cnn(CCOC)c3)ncc2Cl)cc1 CHEMBL3601708 IC50 1.3 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(S(=O)(=O)c3ccc(N5CCOCC5)nc3)C4)n[nH]c2c1 CHEMBL3644621 IC50 1.3 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)c3ccc(F)cc3)CC4)n[nH]c2c1 CHEMBL3644624 IC50 1.3 nM
CCn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(c5ncc(C#N)cn5)C[C@H]4C)c3n2)cn1 CHEMBL3923936 IC50 1.3 nM
C[C@@H]1CN(c2ncc(C#N)cn2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC(C)(C)O)c3)nc12 CHEMBL3924656 IC50 1.3 nM
C[C@H](O)Cn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(C(=O)C5(C#N)CC5)C[C@H]4C)c3n2)cn1 CHEMBL3957457 IC50 1.3 nM
CC[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C[C@H](O)C(F)(F)F)c3)nc12 CHEMBL3983334 IC50 1.3 nM
CCc1cc(O)ccc1-c1ccc2c(-c3nc4c([nH]3)CN(S(C)(=O)=O)CC4)n[nH]c2c1 CHEMBL4069951 IC50 1.3 nM
C=CC(=O)Nc1cccc(CNc2c(C(N)=O)cnn3cccc23)c1 CHEMBL4092337 IC50 1.3 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccccc4Cl)cc23)CC[C@]1(C)N CHEMBL4105015 IC50 1.3 nM
COc1ccccc1-c1cc2c(N[C@@H]3CC[C@](C)(N)C3(C)C)c(C(N)=O)cnn2c1 CHEMBL4071255 IC50 1.3 nM
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(O[C@@H]3CO[C@H]4[C@@H]3OC[C@H]4OCC)n2)ccc1N(C)CCN(C)C CHEMBL5176661 IC50 1.3 nM
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(O[C@@H]3CO[C@H]4[C@@H]3OC[C@H]4OC(C)C)n2)ccc1N(C)CCN(C)C CHEMBL5186937 IC50 1.3 nM
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(O[C@@H]3CO[C@H]4[C@@H]3OC[C@@H]4F)n2)ccc1N(C)CCN(C)C CHEMBL5201705 IC50 1.3 nM
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(O[C@@H]3CO[C@H]4[C@@H]3OC[C@H]4F)n2)ccc1N(C)CCN(C)C CHEMBL5180117 IC50 1.3 nM
Cn1cc(NC(=O)c2cc(C(=O)c3c(Cl)ccc(Cl)c3F)c[nH]2)cn1 CHEMBL5193786 Kd 1.3 nM
C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(OCCCN4CCOCC4)c(Cl)c3)nc3ccsc23)c1 CHEMBL4634992 IC50 1.38 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCC(=O)N4CCOCC4)cc3)ncc2Cl)c1 CHEMBL4289688 IC50 1.39 nM
C[C@H](NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(C)(C)C CHEMBL2325903 IC50 1.4 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3ccc(N4CCOCC4)cc3F)ncc2Cl)c1 CHEMBL3601232 IC50 1.4 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(C(F)F)c3)ncc2Cl)c1 CHEMBL3601106 IC50 1.4 nM
COc1ccc(F)cc1-c1c[nH]c2ncnc(-c3ccccc3)c12 CHEMBL3651059 IC50 1.4 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)c3ccc(Cl)cn3)CC4)n[nH]c2c1 CHEMBL3644641 IC50 1.4 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4cc(Cc5ccc(N6C=CC=CC6)nc5)cnc4[nH]3)n[nH]c2c1 CHEMBL3644643 IC50 1.4 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(Cc3ccccc3)CC4)n[nH]c2c1 CHEMBL3644627 IC50 1.4 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)c3ccc(C#N)nc3)CC4)n[nH]c2c1 CHEMBL3644630 IC50 1.4 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(Cc3ccc5ncccc5c3)C4)n[nH]c2c1 CHEMBL3644631 IC50 1.4 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(Cc3ccnc(C#N)c3)C4)n[nH]c2c1 CHEMBL3644634 IC50 1.4 nM
COc1ccc(-c2cc3c(N[C@@H]4CN(C(=O)CC#N)C[C@@H]4C)c(C(N)=O)cnn3c2)cn1 CHEMBL3667465 IC50 1.4 nM
CCC(=O)N1C[C@H]2C[C@@H](Nc3c(C(N)=O)cnn4cc(-c5ccc(F)nc5)cc34)[C@H](C)[C@H]2C1 CHEMBL3667477 IC50 1.4 nM
CC1(C)CN(c2ncc(C#N)cn2)CC[C@H]1Nc1c(C(N)=O)cnn2cc(N3CCC(CCCC(=O)O)C3=O)cc12 CHEMBL3667480 IC50 1.4 nM
CC[C@@H]1CN(C(=O)[C@H](C)O)CC[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC(C)C)c3)cc12 CHEMBL3667485 IC50 1.4 nM
C[C@H]1CN(C(=O)CC#N)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccc(F)nc3)cc12 CHEMBL3672455 IC50 1.4 nM
C[C@H]1CN(C(=O)CC#N)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccnc(F)c3)cc12 CHEMBL3672456 IC50 1.4 nM
CC[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccc(C)nc3)cc12 CHEMBL3672459 IC50 1.4 nM
C[C@@H]1CN(c2ccc(C#N)cn2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C[C@H](O)C(F)(F)F)c3)nc12 CHEMBL3923801 IC50 1.4 nM
C[C@H](c1ccc(F)cn1)n1c(=O)[nH]c2cnc(Nc3cc(Cl)c[nH]c3=O)nc21 CHEMBL4460058 IC50 1.4 nM
N#CCC(=O)N1CCC[C@H](n2c(=O)[nH]c3cnc(Nc4cc(Cl)c[nH]c4=O)nc32)C1 CHEMBL4443416 IC50 1.4 nM
C[C@@H]1CCN(C(=O)Cn2cnnn2)C[C@@H]1n1c(=O)[nH]c2cnc3[nH]ccc3c21 CHEMBL5268959 IC50 1.4 nM
CCOC(=O)c1c[nH]c2ncnc(-c3ccc4c(c3)CCN4)c12 CHEMBL3650977 IC50 1.5 nM
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4ccc(F)cc4)c23)c1 CHEMBL3651046 IC50 1.5 nM
C=C(C)C(=O)Nc1cc(-c2ncnc3[nH]cc(C(=O)OCC)c23)ccc1C(=O)N(C)C CHEMBL3651007 IC50 1.5 nM
C=C(C)C(=O)Nc1cc(-c2ncnc3[nH]cc(C(=O)OCC)c23)ccc1CN(C)C CHEMBL3651009 IC50 1.5 nM
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4cccc(F)c4Cl)c23)c1 CHEMBL3651047 IC50 1.5 nM
CN1CCN(c2ccc(Nc3nc4c(-c5ccc(CS(C)(=O)=O)cc5)cccn4n3)cc2)CC1 CHEMBL3642285 IC50 1.5 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(S(=O)(=O)c3ccc(Oc5ccccc5)nc3)C4)n[nH]c2c1 CHEMBL3644622 IC50 1.5 nM
C[C@@H]1[C@H]2CN(C(=O)CF)C[C@H]2C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnc(N)c(F)c3)cc12 CHEMBL3667473 IC50 1.5 nM
C[C@@H]1[C@H]2CN(C(=O)C(C)(C)O)C[C@H]2C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)cc12 CHEMBL3667475 IC50 1.5 nM
CC[C@@H]1CN(S(C)(=O)=O)CC[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CCC#N)c3)cc12 CHEMBL3667481 IC50 1.5 nM
CC[C@H]1CN(c2ccc(C#N)cn2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)cc12 CHEMBL3672452 IC50 1.5 nM
CC[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cn(C)nc3C)cc12 CHEMBL3672458 IC50 1.5 nM
CNC(=O)c1cccc(-c2cc3c(N[C@@H]4CN(C(=O)C5(C#N)CC5)C[C@@H]4OC)c(C(N)=O)cnn3c2)c1 CHEMBL3672466 IC50 1.5 nM
CO[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccc(F)cc3)cc12 CHEMBL3672467 IC50 1.5 nM
COC[C@H](O)Cn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(c5ncc(C#N)cn5)C[C@H]4C)c3n2)cn1 CHEMBL3975857 IC50 1.5 nM
C[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)nc12 CHEMBL3929793 IC50 1.5 nM
CCn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(C(=O)C5(C#N)CC5)C[C@H]4C)c3n2)cn1 CHEMBL3950992 IC50 1.5 nM
Cn1ncc2cc(-c3cn4ncc(C(N)=O)c(N[C@@H]5CN(C(=O)C6(C#N)CC6)C[C@@H]5CF)c4n3)ccc21 CHEMBL3899917 IC50 1.5 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccccc4F)cc23)CC[C@]1(C)N CHEMBL4076191 IC50 1.5 nM
COc1ccc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)cc1 CHEMBL4078773 IC50 1.5 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc4c(c3)B(O)OCC4)ncc2C(F)(F)F)c1 CHEMBL4648104 IC50 1.5 nM
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(O[C@@H]3CO[C@H]4[C@@H]3OC[C@H]4O)n2)ccc1N1C[C@H]2C[C@@H]1CN2C CHEMBL5184187 IC50 1.5 nM
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(O[C@@H]3CO[C@H]4[C@@H]3OC[C@H]4O)n2)ccc1N1C[C@@H]2C[C@H]1CO2 CHEMBL5205480 IC50 1.5 nM
CCc1cc(O)c(F)cc1-c1cc(NC(CO)CO)c2nc(N)ncc2c1 CHEMBL5085176 pIC50 1.585 nM
C=CC(=O)Nc1cccc(C(C)Nc2nc(Nc3cnn(CCOC)c3)ncc2Cl)c1 CHEMBL3601710 IC50 1.6 nM
C/C=C/C(=O)Nc1cccc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 CHEMBL3650989 IC50 1.6 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(S(=O)(=O)c3ccc(F)cc3)C4)n[nH]c2c1 CHEMBL3644626 IC50 1.6 nM
[C-]#[N+]c1ccc(-c2cc3c(N[C@H]4CC[C@@](C)(O)CC4)c(C(N)=O)cnn3c2)cc1 CHEMBL3671797 IC50 1.6 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(C(=O)NC5CC5)cc4)cc23)CC[C@]1(C)N CHEMBL3671807 IC50 1.6 nM
Cc1nn(C)c(C)c1-c1cn2ncc(C(N)=O)c(N[C@H]3CN(C(=O)C4(C#N)CC4)C[C@H]3C)c2n1 CHEMBL4106494 IC50 1.6 nM
CC[C@H]1CN(C(=O)C2(C#N)CCC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC)c3)nc12 CHEMBL4112225 IC50 1.6 nM
CC[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3ccnn3C)nc12 CHEMBL3960021 IC50 1.6 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccnc(F)c4)cc23)CC[C@]1(C)N CHEMBL4104127 IC50 1.6 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4cc[nH]n4)cc23)CC[C@]1(C)N CHEMBL4060984 IC50 1.6 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4cccc(F)c4)cc23)CC[C@]1(C)N CHEMBL4071806 IC50 1.6 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)c1ncnc2[nH]ncc12 CHEMBL4763913 IC50 1.6 nM
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(O[C@@H]3CO[C@H]4[C@@H]3OC[C@H]4O)n2)ccc1N1CCOCC1 CHEMBL5182065 IC50 1.6 nM
C=CC(=O)Nc1cccc(Cn2c(=O)ccc3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1 CHEMBL5193728 IC50 1.6 nM
C[C@@H]1CCN(c2ccc(C#N)cn2)C[C@@H]1n1c(=O)[nH]c2cnc3[nH]ccc3c21 CHEMBL5278895 IC50 1.6 nM
CC[C@@H]1CN(C(=O)NCC(F)(F)F)C[C@@H]1c1cnc2cnc3[nH]ccc3n12 CHEMBL3622821 IC50 1.6 nM
Cn1ccc2ncc(-c3cccnc3N[C@H]3CCCN(S(C)(=O)=O)C3)nc21 CHEMBL3665154 Ki 1.627 nM
COc1cc2c(=O)n(CC3CCCCC3)c3c4cc[nH]c4ncc3c2cc1OC CHEMBL4284499 IC50 1.65 nM
N#Cc1ccc(N2CC[C@H](Nc3c(C(N)=O)cnc4[nH]ccc34)[C@H](F)C2)nc1 CHEMBL3593778 IC50 1.7 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3cn(C)nc3C)ncc2Cl)c1 CHEMBL3601243 IC50 1.7 nM
Nc1ccn2ncc(C(=O)Nc3c[nH]nc3-c3cc(Cl)ccc3Cl)c2n1 CHEMBL3670393 Ki 1.7 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(N4CCCC4=O)cc23)CC[C@]1(C)N CHEMBL3671825 IC50 1.7 nM
COc1ccc(-c2cc3c(N[C@@H]4CC[C@](C)(NS(C)(=O)=O)C4(C)C)c(C(N)=O)cnn3c2)cn1 CHEMBL3671827 IC50 1.7 nM
CC[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cn(CC(C)(C)O)nc3C)nc12 CHEMBL3966881 IC50 1.7 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)c3ccc(F)cc3)C4)n[nH]c2c1 CHEMBL3644618 IC50 1.7 nM
O=c1[nH]c2cnc(-n3cnc4ccc(F)cc43)nc2n1[C@@H]1CCOc2c(F)cccc21 CHEMBL1079593 IC50 1.7 nM
C=CC(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL4746272 IC50 1.7 nM
C#CCCN(C)CCN(C)c1ccc(Nc2ncc(Cl)c(O[C@@H]3CO[C@H]4[C@@H]3OC[C@H]4OC)n2)cc1NC(=O)C=C CHEMBL5208026 IC50 1.7 nM
C=CC(=O)Nc1cccc(Cn2c(=O)ccc3cnc(Nc4cnn(CCO)c4)nc32)c1 CHEMBL5208885 IC50 1.7 nM
C[C@H](NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(C)(C)C#N CHEMBL2325906 IC50 1.8 nM
C[C@@H](NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(Cl)cc(F)c34)nc12)C(=O)N1CC(C#N)C1 CHEMBL2376152 IC50 1.8 nM
COc1ccc2c(-c3cnc4[nH]cc(C(=O)N[C@H](C)C(=O)N5CC(C#N)C5)c4n3)nn(C)c2c1 CHEMBL2376149 IC50 1.8 nM
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4cncs4)c23)c1 CHEMBL3651055 IC50 1.8 nM
CCOP(=O)(OCC)O[C@@H]1CCCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 CHEMBL3652409 IC50 1.8 nM
CC(=O)N1CCN(c2cc3c(N[C@@H]4C[C@@H]5CN(S(C)(=O)=O)C[C@@H]5[C@H]4C)c(C(N)=O)cnn3c2)C1=O CHEMBL3667468 IC50 1.8 nM
COC[C@H](O)Cn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(C(=O)C5(C#N)CC5)C[C@H]4C)c3n2)cn1 CHEMBL3921483 IC50 1.8 nM
Cc1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(C(=O)C5(C#N)CC5)C[C@H]4C)c3n2)ccn1 CHEMBL3980081 IC50 1.8 nM
Cc1ccccc1-c1cc2c(N[C@@H]3CC[C@](C)(N)C3(C)C)c(C(N)=O)cnn2c1 CHEMBL4068856 IC50 1.8 nM
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(O[C@@H]3CO[C@H]4[C@@H]3OC[C@H]4O)n2)ccc1N1CCC(N2CCN(C)CC2)CC1 CHEMBL5191734 IC50 1.8 nM
C=CC(=O)Nc1cccc(Cn2c(=O)ccc3cnc(Nc4cnn(C)c4)nc32)c1 CHEMBL5171952 IC50 1.8 nM
CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NC(=O)/C=C(/C)C(F)(F)F)c3)c12 CHEMBL3651026 IC50 1.9 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)c3cc(C#N)ccn3)CC4)n[nH]c2c1 CHEMBL3644623 IC50 1.9 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)c3ccc(C#N)nc3)C4)n[nH]c2c1 CHEMBL3644629 IC50 1.9 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(F)nc4)cc23)CC[C@]1(C)C(N)=O CHEMBL3671830 IC50 1.9 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4cncc(F)c4)cc23)CC[C@]1(C)N CHEMBL4088673 IC50 1.9 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccccc4C#N)cc23)CC[C@]1(C)N CHEMBL4083798 IC50 1.9 nM
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(O[C@@H]3CO[C@H]4[C@@H]3OC[C@H]4O)n2)ccc1N1CCC(N(C)C)C1 CHEMBL5190599 IC50 1.9 nM
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(O[C@@H]3CO[C@H]4[C@@H]3OC[C@H]4O)n2)ccc1N(C)CCN(C)C CHEMBL5174210 IC50 1.9 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 1.995 nM
CCc1cc(O)c(F)cc1-c1cc(NS(=O)(=O)c2ccccn2)c2cn[nH]c2c1 CHEMBL4528395 pIC50 1.995 nM
C=C(C)[C@H]1CC[C@@H](C)[C@@H](N(C)c2ncnc3[nH]ccc23)C1 CHEMBL1630782 IC50 2.0 nM
N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL1789941 Kd 2.0 nM
CC(C)(C)CS(=O)(=O)N1CCC[C@H](NC(=O)Nc2cnc3[nH]ccc3n2)C1 CHEMBL3335686 IC50 2.0 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3ccc(N4CCN(C)CC4)c(Cl)c3)ncc2Cl)c1 CHEMBL3601228 IC50 2.0 nM
C=CC(=O)Nc1ccc(CNc2nc(Nc3cnn(CC(=O)NC)c3)ncc2Cl)cc1 CHEMBL3601707 IC50 2.0 nM
CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NC(=O)/C=C/c4ccncc4)c3)c12 CHEMBL3651024 IC50 2.0 nM
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(C(=O)OC)c23)c1 CHEMBL3651035 IC50 2.0 nM
C[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC(C)(C)O)c3)nc12 CHEMBL3958864 IC50 2.0 nM
CC[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3ccnc(C)c3)nc12 CHEMBL3917516 IC50 2.0 nM
CN1CCC(NC(=O)c2ccc(Nc3cc(NCc4ccccc4)c(C(N)=O)cn3)cc2)CC1 CHEMBL4096246 IC50 2.0 nM
N#CN[C@@H]1c2cc(-c3ncnc4[nH]ccc34)ccc2C[C@H]1O CHEMBL4281693 IC50 2.0 nM
C=CC(=O)N1CCN(c2ccc(C(F)(F)F)c(C3=C(c4cn(C)c5ccccc45)C(=O)NC3=O)c2)CC1 CHEMBL4461890 IC50 2.0 nM
COc1ccc(-c2cc3c(NC(CO)[C@H](O)C4CC4)c(C(N)=O)cnn3c2)cn1 CHEMBL4440767 IC50 2.0 nM
COc1ccc(-c2cc3c(N[C@H](CO)[C@@H](C)O)c(C(N)=O)cnn3c2)cn1 CHEMBL4547761 IC50 2.0 nM
O=C(CCCCCCn1cc(Nc2ncc(Cl)c(NC3CC3)n2)cn1)NO CHEMBL4466059 IC50 2.0 nM
C=CC(=O)Nc1cccc(Cn2c(=O)ccc3cnc(Nc4ccc(N5CCN(C)CC5)cc4)nc32)c1 CHEMBL5194482 IC50 2.0 nM
C=CC(=O)Nc1cccc(Cn2c(=O)ccc3cnc(Nc4cnn(C5CCN(C)CC5)c4)nc32)c1 CHEMBL5182971 IC50 2.0 nM
CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NC(=O)/C=C/COC)c3)c12 CHEMBL3651019 IC50 2.1 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(F)cc4)cc23)CC[C@]1(C)N CHEMBL4077508 IC50 2.1 nM
NC(=O)c1cnc2[nH]ccc2c1NC1C2CC3CC1CC(F)(C3)C2 CHEMBL4247874 IC50 2.1 nM
NC(=O)c1cnc2[nH]ccc2c1NC1C2CC3CC(C2)CC1C3 CHEMBL4249444 IC50 2.1 nM
C=CC(=O)Nc1cccc(CNc2cc(Nc3ccc(N4CCN(C)CC4)cc3)ncn2)c1 CHEMBL3601722 IC50 2.1 nM
C[C@@H]1CCN(C(=O)N2CCCCC2)C[C@@H]1n1c(=O)[nH]c2cnc3[nH]ccc3c21 CHEMBL5284080 IC50 2.1 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(Cc3ccc(O)cc3)C4)n[nH]c2c1 CHEMBL3644632 IC50 2.2 nM
COc1cccc(-c2cn3ncc(C(N)=O)c(N[C@@H]4CN(C(=O)C5(C#N)CC5)C[C@@H]4C)c3n2)n1 CHEMBL3922507 IC50 2.2 nM
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(O[C@@H]3CO[C@H]4[C@@H]3OC[C@H]4O)n2)ccc1N1CCN(CC)CC1 CHEMBL5184019 IC50 2.2 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 2.3 nM
C[C@@H](NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(C#N)ccc34)nc12)C(=O)N1CC(C#N)C1 CHEMBL2376148 IC50 2.3 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(CCOCCOCCOCCNC(=O)CCCC[C@@H]4SC[C@@H]5NC(=O)N[C@@H]54)c3)ncc2Cl)c1 CHEMBL3601862 IC50 2.3 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3ccc(N4CCN(C)CC4)cc3OC)ncc2Br)c1 CHEMBL3601715 IC50 2.3 nM
CCOC(=O)c1c[nH]c2ncnc(-c3ccc(N)cc3)c12 CHEMBL3650980 IC50 2.3 nM
C=C(C)C(=O)N1CCc2ccc(-c3ncnc4[nH]cc(C(=O)OCC)c34)cc21 CHEMBL3651001 IC50 2.3 nM
CC[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C(F)F)c3)nc12 CHEMBL3908821 IC50 2.3 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCN(Cc2ccc(Cl)cc2)[C@@H](C)C1 CHEMBL4783938 IC50 2.31 nM
CC(=O)N1CCCC(Nc2ncccc2-c2cnc3nc[nH]c3n2)C1 CHEMBL3665170 Ki 2.339 nM
Clc1cnc2nc1NCc1cccc(c1)OCCCc1cccc(c1)N2 CHEMBL3694581 IC50 2.4 nM
CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NC(=O)/C=C/c4c[nH]c5ccccc45)c3)c12 CHEMBL3651025 IC50 2.4 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(Cc3ccc(Oc5ccccc5)nc3)C4)n[nH]c2c1 CHEMBL3644637 IC50 2.4 nM
Cc1c[nH]c(=O)c(Nc2ncc3[nH]c(=O)n([C@@H]4CCOc5c(F)cccc54)c3n2)c1 CHEMBL4536419 IC50 2.4 nM
C=CC(=O)Nc1cccc(CNc2cc(Nc3ccc(N4CCOCC4)cc3)ncn2)c1 CHEMBL4573218 IC50 2.4 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(C#N)cc2)[C@H](C)C1 CHEMBL4744772 IC50 2.41 nM
N[C@H]1CC[C@@H](Nc2cc[nH]c(=O)c2-c2nc3ccccc3[nH]2)CC1 CHEMBL3780091 IC50 2.5 nM
C[C@@H]1CN(C(=O)C2(C#N)CC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3ccnn3C)nc12 CHEMBL3943940 IC50 2.5 nM
CC(C)n1cc(-c2cn3ncc(C(N)=O)c(N[C@@H]4CN(C(=O)C5(C#N)CC5)C[C@@H]4CF)c3n2)cn1 CHEMBL3891603 IC50 2.5 nM
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(O[C@@H]3CO[C@H]4[C@@H]3OC[C@H]4O)n2)ccc1N1CCC(N(C)C)CC1 CHEMBL5185016 IC50 2.5 nM
Cc1c[nH]c2ncc3ccn([C@H]4CN(C(=O)CC#N)CC[C@H]4C)c3c12 CHEMBL5271864 IC50 2.5 nM
CCc1cc(O)c(F)cc1-c1cc(NS(=O)(=O)C(C)C)c2cn[nH]c2c1 CHEMBL4517645 pIC50 2.512 nM
CCc1cc(O)c(F)cc1-c1cc(NS(=O)(=O)CC)c2cn[nH]c2c1 CHEMBL4483364 pIC50 2.512 nM
CCc1cc(O)c(F)cc1-c1cc(NS(C)(=O)=O)c2cn[nH]c2c1 CHEMBL4539949 pIC50 2.512 nM
CCc1cc(O)c(F)cc1-c1cc(NC[C@@H](C)O)c2nc(N)ncc2c1 CHEMBL5079248 pIC50 2.512 nM
COc1cc2c(=O)n([C@@H]3CCCN(C(=O)CC#N)C3)c3c4cc[nH]c4ncc3c2cc1OC CHEMBL4290597 IC50 2.55 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(Cc3cccc(OC)c3)C4)n[nH]c2c1 CHEMBL3644635 IC50 2.6 nM
O=c1[nH]c2cnc(-c3cnc4ccc(F)cn34)nc2n1[C@@H]1CCOc2c(F)cccc21 CHEMBL4448906 IC50 2.6 nM
C[C@H](c1ccccc1)n1c(=O)[nH]c2cnc(-c3cnc4ccc(F)cn34)nc21 CHEMBL4450301 IC50 2.7 nM
CC(C)[C@H](C)n1cc(-c2cc(N3CCOCC3)n(C)n2)c2[nH]nc(N)c2c1=O CHEMBL3763213 IC50 2.8 nM
COc1cc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)ccn1 CHEMBL4069127 IC50 2.8 nM
C=CC(=O)N1CCN(c2ccc(C(F)(F)F)c(C3=C(c4c[nH]c5cc(F)ccc45)C(=O)NC3=O)c2)CC1 CHEMBL4444087 IC50 2.8 nM
O=c1[nH]cccc1Nc1ncc2[nH]c(=O)n([C@@H]3CCOc4c(F)cccc43)c2n1 CHEMBL4558494 IC50 2.8 nM
C[C@@H]1CCN(C(=O)N2CCCC2)C[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL4068357 IC50 2.8 nM
CN(c1ccccc1-c1cc(Cl)c2cnc(Nc3ccc(C4CCN(CC(N)=O)CC4)cc3)nn12)S(C)(=O)=O CHEMBL1934353 IC50 2.9 nM
C[C@@H](NC(=O)c1c[nH]c2ncc(-c3nn(C)c4ccccc34)nc12)C(=O)N1CC(C#N)C1 CHEMBL2376146 IC50 2.9 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnoc3)ncc2Cl)c1 CHEMBL3601244 IC50 2.9 nM
COCC(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL3645119 Kd 2.9 nM
Cc1ccc(C)c(-c2nn(C)cc2NC(=O)c2cnn3ccc(N)nc23)c1 CHEMBL2178803 Ki 2.9 nM
CC(C)n1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(C(=O)C5(C#N)CC5)C[C@H]4C)c3n2)cn1 CHEMBL3968963 IC50 2.9 nM
CCc1cc(O)ccc1-c1ccc2c(-c3nc4c([nH]3)CN(C)CC4)n[nH]c2c1 CHEMBL4066236 IC50 2.9 nM
COc1cc2c(=O)n(C3CCCCC3)c3c4cc[nH]c4ncc3c2cc1OC CHEMBL4295151 IC50 2.92 nM
O=C1NCc2c1c1c3cc(/C=C/Cn4ccnc4)ccc3n3c1c1c2c2cc(CO)ccc2n1CC(CO)C3 CHEMBL234066 IC50 3.0 nM
O=C1NCc2c1c1c3ccccc3n3c1c1c2c2cc(CO)ccc2n1CC(CO)C3 CHEMBL234936 IC50 3.0 nM
O=C1NC(=O)c2c1c1c3ccccc3n3c1c1c2c2ccccc2n1C[C@H](O)[C@H](O)C3 CHEMBL563588 IC50 3.0 nM
C[C@@H](NC(=O)c1c[nH]c2ncc(-c3nn(C)c4ccc(Cl)cc34)nc12)C(=O)N1CC(C#N)C1 CHEMBL2376145 IC50 3.0 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cccc23)CC[C@@]1(C)O CHEMBL3359915 IC50 3.0 nM
C[C@@H]1CCCC[C@@H]1n1c(=O)[nH]c2cnc3[nH]ccc3c21 CHEMBL3593579 IC50 3.0 nM
CC[C@@H]1CCCC[C@@H]1n1c(=O)[nH]c2cnc3[nH]ccc3c21 CHEMBL3593584 IC50 3.0 nM
CCCS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3nc[nH]c3n2)C1 CHEMBL3665162 IC50 3.0 nM
CNC(=O)[C@H]1CCCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)C1 CHEMBL3645120 Kd 3.0 nM
CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3cc[nH]c3n2)C1 CHEMBL3665165 IC50 3.0 nM
CN(C)CCN1C(=O)S/C(=C\c2ccc(Nc3cnc4[nH]cc(C(=O)C(C)(C)C)c4n3)cc2)C1=O CHEMBL3950608 IC50 3.0 nM
CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(/C=C4\SC(=O)N(CCN)C4=O)cc3)nc12 CHEMBL3959163 IC50 3.0 nM
COc1ccc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(C(=O)C5(C#N)CC5)C[C@H]4C)c3n2)cn1 CHEMBL3980515 IC50 3.0 nM
NC(=O)c1cnc(Nc2ccc3c(c2)CC(=O)N3)cc1NCc1ccccc1 CHEMBL4098698 IC50 3.0 nM
NC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1NCc1cc(F)ccc1F CHEMBL4068975 IC50 3.0 nM
COCCc1c[nH]c2ncnc(-c3ccc4c(c3)N(C#N)CC(F)(F)O4)c12 CHEMBL4284396 IC50 3.0 nM
N#CN[C@H]1CCc2ccc(-c3ncnc4[nH]ccc34)cc21 CHEMBL4281393 IC50 3.0 nM
COc1ccc(-c2cc3c(N[C@H](CO)CC(C)C)c(C(N)=O)cnn3c2)cn1 CHEMBL4467881 IC50 3.0 nM
C[C@@H](O)[C@@H](CO)Nc1c(C(N)=O)cnn2cc(-c3ccccc3)cc12 CHEMBL4447360 IC50 3.0 nM
CC(C)(C#N)c1cccc(-c2ccnc3[nH]ccc23)n1 CHEMBL4453941 Ki 3.0 nM
C[C@H](c1ccc(F)cn1)n1c(=O)[nH]c2cnc(-c3cnc4ccc(F)cn34)nc21 CHEMBL4536396 IC50 3.0 nM
C=CC(=O)Nc1cccc(Cn2c(=O)ccc3cnc(Nc4ccccc4OC)nc32)c1 CHEMBL5196607 IC50 3.0 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC CHEMBL4435170 IC50 3.0 nM
COc1ccccc1Nc1cc(Nc2ccc(CC(=O)O[C@@H]3CCOC3)cn2)ncc1C(N)=O CHEMBL5407260 IC50 3.0 nM
C[C@@H](NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(C5CC5)ccc34)nc12)C(=O)N1CC(C#N)C1 CHEMBL2376150 IC50 3.1 nM
COC(=O)Cc1ccc(OC)c(-c2c[nH]c3ncnc(-c4ccccc4)c23)c1 CHEMBL3651056 IC50 3.1 nM
C[C@@H]1CN(c2nnc(C(F)(F)F)s2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(CC(C)(C)O)c3)nc12 CHEMBL3985826 IC50 3.1 nM
C=CC(=O)Nc1cccc(Cn2c(=O)ccc3cnc(Nc4ccc(N(C)CCN(C)C)cc4OC)nc32)c1 CHEMBL5186701 IC50 3.1 nM
Cn1cc(Nc2ncc(Br)c(Nc3ccccc3C(N)=O)n2)cn1 CHEMBL1994669 pKi 3.162 nM
CC1CCN(C(=O)CC#N)CC1c1ncc2cnc3[nH]ccc3n12 CHEMBL1966175 pKi 3.162 nM
CCc1cc(O)c(F)cc1-c1cc(NS(=O)(=O)N(C)C)c2cn[nH]c2c1 CHEMBL4534573 pIC50 3.162 nM
CCc1cc(O)c(F)cc1-c1cc(NS(=O)(=O)c2ccccc2Cl)c2cn[nH]c2c1 CHEMBL4560212 pIC50 3.162 nM
CCc1cc(O)c(F)cc1-c1cc(NS(=O)(=O)CCC(=O)OC)c2cn[nH]c2c1 CHEMBL4483513 pIC50 3.162 nM
CCc1cc(O)c(F)cc1-c1cc(NS(=O)(=O)C2CC2)c2cn[nH]c2c1 CHEMBL4554460 pIC50 3.162 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@H](C)CO)c2nc(N)ncc2c1 CHEMBL5074310 pIC50 3.162 nM
CCc1cc(O)c(F)cc1-c1cc(NC2CCN(C)CC2)c2nc(N)ncc2c1 CHEMBL5077126 pIC50 3.162 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@@H]2C[C@H]3CC[C@@H](C2)N3)c2nc(N)ncc2c1 CHEMBL5075673 pIC50 3.162 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@@H](C)CO)c2nc(NCCOCCN(C)C)ncc2c1 CHEMBL5094089 pIC50 3.162 nM
NC(=O)c1cnc2[nH]ccc2c1N[C@@H]1C[C@H]2CC[C@@H]1C2 CHEMBL4241916 IC50 3.2 nM
CCN1CCN(c2ccc(Nc3ncc4scc(-c5cccc(NS(C)(=O)=O)c5)c4n3)cc2)CC1 CHEMBL4846921 IC50 3.2 nM
Cc1nc2cnc3ccc(-c4cc(Cl)c(O)c(Cl)c4)cc3c2n1[C@@H]1CCCN(C)C1 CHEMBL5192754 IC50 3.2 nM
CCOC(=O)c1c[nH]c2ncnc(-c3ccc(N(C)C)cc3)c12 CHEMBL3703503 IC50 3.3 nM
CCOC(=O)c1c[nH]c2ncnc(-c3cccc(OCc4ccccc4)c3)c12 CHEMBL3703506 IC50 3.3 nM
CC(C)[C@@H](C)n1cc(-c2cc(C(C)(C)O)n(C)n2)c2[nH]nc(N)c2c1=O CHEMBL3765822 IC50 3.3 nM
N#CCC(=O)N1CC(F)(F)C12CCCN(c1ncnc3[nH]ccc13)C2 CHEMBL3689517 IC50 3.3 nM
COc1ccc(-c2cc3c(N[C@H]4CCN(C(=O)[C@H](C)O)CC4(C)C)c(C(N)=O)cnn3c2)cn1 CHEMBL3672471 IC50 3.3 nM
C=CC(=O)N1CCN(c2ccc(Cl)c(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c2)CC1 CHEMBL4470305 Ki 3.3 nM
O=C(CCCCCCn1cc(Nc2ncc(Cl)c(Nc3cccc(Cl)c3)n2)cn1)NO CHEMBL4471710 IC50 3.3 nM
C=CC(=O)Nc1cccc(Cn2c(=O)ccc3cnc(Nc4ccc(N5CCN(C(C)=O)CC5)cc4OC)nc32)c1 CHEMBL5180842 IC50 3.3 nM
C=CC(=O)Nc1cccc(Cn2c(=O)ccc3cnc(Nc4cnn(CCOC)c4)nc32)c1 CHEMBL5200659 IC50 3.3 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(Cl)cc2)[C@H](C)C1 CHEMBL4761365 IC50 3.36 nM
C[C@@H](NC(=O)c1c[nH]c2ncc(-c3cnc4cc(Cl)ccn34)nc12)C(=O)N1CC(C#N)C1 CHEMBL2376159 IC50 3.4 nM
N#Cc1ccc(N2CCC(Nc3c(C(N)=O)cnc4[nH]ccc34)CC2)cc1 CHEMBL3593770 IC50 3.4 nM
COc1ccccc1-c1c[nH]c2ncnc(-c3ccccc3)c12 CHEMBL3651057 IC50 3.4 nM
CC1CN(C(=O)CC#N)C12CCCN(c1ncnc3[nH]ccc13)C2 CHEMBL3689514 IC50 3.4 nM
CCCn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(C(=O)C5(C#N)CC5)C[C@H]4CF)c3n2)cn1 CHEMBL3919654 IC50 3.4 nM
O=c1[nH]cccc1Nc1ncc2[nH]c(=O)n([C@@H]3CC[C@@H](O)c4ccccc43)c2n1 CHEMBL4556988 IC50 3.4 nM
Cc1cnc(Nc2cnn(C)c2)nc1-c1cnn([C@H](CC#N)C2CCCC2)c1 CHEMBL5395308 IC50 3.4 nM
CCOC(=O)c1c[nH]c2ncnc(-c3cccc(OCC(F)(F)F)c3)c12 CHEMBL3703488 IC50 3.5 nM
C=CS(=O)(=O)Nc1cccc(CNc2c(C(N)=O)cnn3cccc23)c1 CHEMBL4084598 IC50 3.5 nM
Clc1cccc(Nc2nc(Nc3cn[nH]c3)ncc2Cl)c1 CHEMBL4453646 IC50 3.5 nM
N#CC[C@H]1CC[C@H](n2c(=O)[nH]c3cnc(Nc4ccc[nH]c4=O)nc32)CC1 CHEMBL4463007 IC50 3.5 nM
CN1CCN(c2ccc(Nc3cc(NCc4cccc(NC(=O)CC#N)c4)ncn3)cc2)CC1 CHEMBL4546009 IC50 3.5 nM
N#Cc1cnc(N2CCC(Nc3c(C(N)=O)cnc4[nH]ccc34)CC2)cn1 CHEMBL3593775 IC50 3.6 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3cc(F)c(N4CCN(C(C)=O)CC4)c(F)c3)ncc2Cl)c1 CHEMBL3601236 IC50 3.6 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4cc(C(=O)c5ccc(Oc6ccccc6F)cc5OCC(C)NN)cnc4[nH]3)n[nH]c2c1 CHEMBL3644642 IC50 3.6 nM
Cc1nn(C)c(C)c1-c1cn2ncc(C(N)=O)c(N[C@H]3CN(C(=O)C(C)(C)C#N)C[C@H]3C)c2n1 CHEMBL3951139 IC50 3.6 nM
N#CCC(=O)N1CCC[C@H](n2c(=O)[nH]c3cnc(Nc4ccc[nH]c4=O)nc32)C1 CHEMBL4550310 IC50 3.6 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(C(F)(F)F)cc2)[C@H](C)C1 CHEMBL5398372 IC50 3.63 nM
N#CC1(C(=O)N2C[C@H](CF)[C@H](Nc3c(C(N)=O)cnn4cc(-c5cnn(C6CC6)c5)nc34)C2)CC1 CHEMBL3906388 IC50 3.7 nM
O=C(CCCCCCn1cc(Nc2ncc(Cl)c(N3CCCCC3)n2)cn1)NO CHEMBL4562491 IC50 3.7 nM
C=CC(=O)N1CCC[C@H]1COc1nc(Nc2ccc(N3CCN(C(C)=O)CC3)cc2)nc2[nH]cc(-c3cncc(NC)n3)c12 CHEMBL4543893 IC50 3.7 nM
N#CCC(=O)N1CCC[C@@H](n2cnc3cnc4[nH]ccc4c32)C1 CHEMBL2152300 Ki 3.8 nM
CCOC(=O)c1c[nH]c2ncnc(-c3ccc4c(c3)OCO4)c12 CHEMBL3703504 IC50 3.8 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4cccc(C#N)c4)cc23)CC[C@]1(C)N CHEMBL4070687 IC50 3.8 nM
CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@@H](OC(=O)C(C)(C)C)C2)CC1 CHEMBL3652403 IC50 3.89 nM
CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NC(=O)/C=C/c4nccs4)c3)c12 CHEMBL3651028 IC50 3.9 nM
C[C@H](c1ncc(F)cn1)n1c(=O)[nH]c2cnc(-c3cnc4ccc(F)cn34)nc21 CHEMBL4469844 IC50 3.9 nM
CN(c1ncnc2[nH]ccc12)N1CCC[C@@H](C(=O)NCC#N)C1 CHEMBL5191898 IC50 3.9 nM
CCC1CC(NS(=O)(=O)C2CC2)CC1c1ncc2cnc3[nH]ccc3n12 CHEMBL1992073 pKi 3.981 nM
CCc1cc(O)c(F)cc1-c1cc(NS(=O)(=O)CCOC)c2cn[nH]c2c1 CHEMBL4569613 pIC50 3.981 nM
CCc1cc(O)c(F)cc1-c1cc(NS(=O)(=O)C2CCCC2)c2cn[nH]c2c1 CHEMBL4521312 pIC50 3.981 nM
CCc1cc(O)c(F)cc1-c1cc(NS(=O)(=O)CC2CCC2)c2cn[nH]c2c1 CHEMBL4580425 pIC50 3.981 nM
C=C(C)[C@H]1CCC(C)[C@@H](N(C)c2ncnc3[nH]ccc23)C1 CHEMBL1630781 IC50 4.0 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)c(F)c(N3CCS(=O)(=O)CC3)n2)n[nH]1 CHEMBL2381986 IC50 4.0 nM
CCOC(=O)c1c[nH]c2ncnc(-c3cc4ccccc4o3)c12 CHEMBL3650978 IC50 4.0 nM
CC(C)[C@H](C)n1cc(-c2cc(N3CCS(=O)(=O)CC3)n(C)n2)c2[nH]nc(N)c2c1=O CHEMBL3765517 IC50 4.0 nM
CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(/C=C4\SC(=O)NC4=O)cc3)nc12 CHEMBL3941879 IC50 4.0 nM
CCn1cc(-c2cn3ncc(C(N)=O)c(N[C@H]4CN(C(=O)C5(C#N)CC5)C[C@H]4CF)c3n2)cn1 CHEMBL3928562 IC50 4.0 nM
Cc1cnccc1-c1cc2c(N[C@@H]3CC[C@](C)(N)C3(C)C)c(C(N)=O)cnn2c1 CHEMBL4084341 IC50 4.0 nM
C=CC(=O)N1CCN(c2ccc(C(F)(F)F)c(C3=C(c4c[nH]c5ncccc45)C(=O)NC3=O)c2)CC1 CHEMBL4522075 IC50 4.0 nM
CC(C)CNc1c(C(N)=O)cnn2cc(-c3ccccc3)cc12 CHEMBL4440261 IC50 4.0 nM
COC[C@@H](C)OC(=O)Cc1ccc(Nc2cc(Nc3ccccc3OC)c(C(N)=O)cn2)nc1 CHEMBL5404574 IC50 4.0 nM
COCCOC(=O)Cc1ccc(Nc2cc(Nc3ccccc3OC)c(C(N)=O)cn2)nc1 CHEMBL5422886 IC50 4.0 nM
NC(=O)c1cnc(Nc2ccc(N3CCC[C@@H](C(N)=O)C3)cc2)nc1NC1CC1 CHEMBL3645122 Kd 4.1 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(Cc3cccnc3C#N)C4)n[nH]c2c1 CHEMBL3644638 IC50 4.1 nM
C=CC(=O)Nc1cccc(Cn2c(=O)ccc3cnc(Nc4ccc(C5CCN(C)CC5)cc4OC)nc32)c1 CHEMBL5206323 IC50 4.1 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1n1ncc2cnc3[nH]ccc3c21 CHEMBL5276916 IC50 4.1 nM
CCOC(=O)c1c[nH]c2ncnc(-c3ccc(-c4ccccc4)cc3)c12 CHEMBL3703500 IC50 4.2 nM
C=CC(=O)N1CCC(Oc2nc(Nc3ccc(N4CCOCC4)cc3)nc3[nH]cc(-c4ccnc(NC)c4)c23)CC1 CHEMBL4549626 IC50 4.2 nM
CCc1cc(O)ccc1-c1ccc2c(C(N)=O)n[nH]c2c1 CHEMBL4096219 IC50 4.3 nM
C=CC(=O)Nc1cc(CNc2nc(Nc3cnn(C)c3)ncc2Cl)ccc1F CHEMBL3601127 IC50 4.4 nM
Cc1nn(C)cc1-c1cn2ncc(C(N)=O)c(N[C@H]3CN(C(=O)C(C)(C)C#N)C[C@H]3C)c2n1 CHEMBL3890788 IC50 4.4 nM
C=CC(=O)N(C)C1CCN(c2ccc(C(F)(F)F)c(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c2)C1 CHEMBL4464446 IC50 4.4 nM
Cn1cc(-c2cn3ncc(C(N)=O)c(N[C@@H]4CN(C(=O)C5(C#N)CC5)C[C@@H]4CF)c3n2)cn1 CHEMBL3904090 IC50 4.5 nM
NC(=O)c1cnc(Nc2ccccc2)cc1NCc1ccccc1 CHEMBL4072239 IC50 4.5 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3cc(F)c(N4CCN(C)CC4)cc3F)ncc2Cl)c1 CHEMBL3601230 IC50 4.6 nM
CCOC(=O)c1c[nH]c2ncnc(-c3ccc4c(c3)NCC4)c12 CHEMBL3703493 IC50 4.6 nM
CCOC(=O)c1c[nH]c2ncnc(-c3ccc(C)c(N)c3)c12 CHEMBL3703489 IC50 4.6 nM
CC(C)[C@H](C)n1cc(-c2cc(C3CCOCC3)n(C)n2)c2[nH]nc(N)c2c1=O CHEMBL3764277 IC50 4.6 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccncc4F)cc23)CC[C@]1(C)N CHEMBL4079880 IC50 4.6 nM
NC(=O)c1cnn2cc(-c3ccc(F)cc3)cc2c1NC12CC3CC(O)(CC(O)(C3)C1)C2 CHEMBL3671817 IC50 4.7 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3ccc(N4CCN(C)CC4)cc3OC)ncc2Cl)c1 CHEMBL3601223 IC50 4.8 nM
CCOC(=O)c1c[nH]c2ncnc(-c3cc4ccccc4s3)c12 CHEMBL3703505 IC50 4.8 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(Cl)nc2)[C@H](C)C1 CHEMBL5427932 IC50 4.81 nM
N#CCC(=O)Nc1ccc(CNc2cc(Nc3ccc(N4CCOCC4)cc3)ncn2)cc1 CHEMBL4518786 IC50 4.84 nM
CN(C)C(=O)CN1CN([C@H]2CC[C@H](CNCC(F)(F)F)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3901870 IC50 4.9 nM
CN1CN([C@H]2CC[C@H](COCCC#N)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3896113 IC50 4.9 nM
CC1(C)CC(n2c(=O)[nH]c3cnc(-c4cnc5ccc(F)cn45)nc32)CCO1 CHEMBL4574559 IC50 4.9 nM
Cc1nc2cnc3ccc(-c4cc(Cl)c(O)c(Cl)c4)cc3c2n1C1CCCN(C)C1 CHEMBL5187370 IC50 4.9 nM
CC(C)(C)c1nc2c3ccc(F)cc3c3c(=O)[nH]ccc3c2[nH]1 CHEMBL21156 IC50 5.0 nM
O=C1NC(=O)c2c1c1c3ccccc3n3c1c1c2c2ccccc2n1CC(O)CC3 CHEMBL562934 IC50 5.0 nM
CC(=O)N[C@@H]1CCc2ccc(Oc3cnc4[nH]cc(C(=O)N[C@@H](C(=O)N5CC(C#N)C5)C5CC5)c4n3)cc21 CHEMBL2376439 IC50 5.0 nM
CC1(C)CCC[C@H]1Nc1c(C(N)=O)cnn2cccc12 CHEMBL3359908 IC50 5.0 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cccc23)CC[C@]1(C)N CHEMBL3359921 IC50 5.0 nM
CC(C)CS(=O)(=O)N1C[C@@H](C)C[C@H](NC(=O)Nc2cnc3[nH]ccc3n2)C1 CHEMBL3335687 IC50 5.0 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1n1c(=O)n(C)c2cnc3[nH]ccc3c21 CHEMBL3593592 IC50 5.0 nM
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(C4=CCOCC4)c23)c1 CHEMBL3651053 IC50 5.0 nM
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4cnco4)c23)c1 CHEMBL3651065 IC50 5.0 nM
C[C@@H]1CN(C(=O)C2(C#N)CCC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)nc12 CHEMBL4108712 IC50 5.0 nM
NC(=O)c1cnn2cc(-c3ccccc3)cc2c1NC1CCCC1 CHEMBL4472924 IC50 5.0 nM
Cc1cc(Nc2nc([C@@H](O)c3ccc(F)cc3)nc3ccccc23)n[nH]1 CHEMBL3939800 Kd 5.0 nM
COc1ccccc1Nc1cc(Nc2ccc(CC(=O)O[C@H]3CCOC3)cn2)ncc1C(N)=O CHEMBL5396554 IC50 5.0 nM
O=c1[nH]c2cnc(-n3cnc4ccc(F)cc43)nc2n1C1CCOc2c(F)cccc21 CHEMBL2000393 pKi 5.012 nM
CC1CCN(C(=O)CC#N)CC1N(C)c1ncnc2[nH]ccc12 CHEMBL234085 pKi 5.012 nM
CCc1cc(O)c(F)cc1-c1cc(NS(=O)(=O)c2cccnc2)c2cn[nH]c2c1 CHEMBL4563039 pIC50 5.012 nM
CCc1cc(O)c(F)cc1-c1cc(NCCO)c2nc(N)ncc2c1 CHEMBL5082928 pIC50 5.012 nM
CCc1cc(O)c(F)cc1-c1cc(NCCCO)c2nc(N)ncc2c1 CHEMBL5084340 pIC50 5.012 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@@H]2CCCN(C)C2)c2nc(N)ncc2c1 CHEMBL5087255 pIC50 5.012 nM
CCc1cc(O)c(F)cc1-c1cc(N[C@@H](C)CO)c2nc(NCCCN(C)C)ncc2c1 CHEMBL5076101 pIC50 5.012 nM
C[C@@H]1CCCC[C@@H]1Nc1c(C(N)=O)cnc2[nH]ccc12 CHEMBL3593761 IC50 5.1 nM
N#CCC(=O)N1CC(F)(F)C12CCN(c1ncnc3[nH]ccc13)C2 CHEMBL3689516 IC50 5.1 nM
C[C@]1(O)CCCC[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3ccccc3)cc12 CHEMBL3671821 IC50 5.1 nM
Cc1cc(-c2cn3ncc(C(N)=O)c(N[C@@H]4CN(C(=O)C5(C#N)CC5)C[C@@H]4CF)c3n2)ccn1 CHEMBL3927910 IC50 5.1 nM
CCn1cc(-c2cnc3[nH]cc(C(=O)N[C@H](C)C(=O)N4CC(C#N)C4)c3n2)cn1 CHEMBL2376142 IC50 5.2 nM
NC(=O)c1ccc(N2CCC(Nc3c(C(N)=O)cnc4[nH]ccc34)CC2)nc1 CHEMBL3593773 IC50 5.2 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3cc(F)c(N4CCOCC4)cc3F)ncc2Cl)c1 CHEMBL3601234 IC50 5.2 nM
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4ccccc4C)c23)c1 CHEMBL3651048 IC50 5.2 nM
CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NC(=O)/C=C/C(C)=O)c3)c12 CHEMBL3651022 IC50 5.3 nM
CC(C)C(C)n1cc(-c2ccc(N3CCOCC3)cn2)c2[nH]nc(N)c2c1=O CHEMBL3763252 IC50 5.3 nM
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4ccc(C)cc4)c23)c1 CHEMBL3651049 IC50 5.4 nM
CN1CN([C@H]2CC[C@H](CNS(=O)(=O)CC(F)(F)F)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3947242 IC50 5.4 nM
C=CC(=O)N1CCN(c2ccc(C(F)(F)F)c(C3=C(c4c[nH]c5ccc(F)cc45)C(=O)NC3=O)c2)CC1 CHEMBL4441142 IC50 5.4 nM
O=C1Nc2ccccc2-c2ccnc3[nH]cc(c23)C1c1ccc(O)cc1 CHEMBL584052 Ki 5.5 nM
CCOC(=O)c1c[nH]c2ncnc(-c3ccccc3)c12 CHEMBL3703485 IC50 5.5 nM
COc1cncc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)c1 CHEMBL3671815 IC50 5.5 nM
COc1ccc(Cl)cc1-c1c(NC(=O)c2c(N)nn3cccnc23)cnn1CC(N)=O CHEMBL3667521 Ki 5.5 nM
CN(C(=O)/C(C#N)=C/c1ccc(Nc2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)cc1)c1ccccc1 CHEMBL3949322 IC50 5.5 nM
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(O[C@@H]3CO[C@H]4[C@@H]3OC[C@H]4O)n2)ccc1N1CCC2(CCN(C)CC2)CC1 CHEMBL5207354 IC50 5.5 nM
C[C@@H]1CCN(C(=O)N2CCOCC2)C[C@@H]1n1c(=O)[nH]c2cnc3[nH]ccc3c21 CHEMBL5268710 IC50 5.5 nM
CCOC(=O)c1c[nH]c2ncnc(-c3cccc(O)c3)c12 CHEMBL3703501 IC50 5.6 nM
CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(Cc3cccc(O)c3)C4)n[nH]c2c1 CHEMBL3644633 IC50 5.6 nM
Cn1nccc1-c1cc2c(N[C@@H]3C[C@@H](O)[C@@H](O)C3(C)C)c(C(N)=O)cnn2c1 CHEMBL3671792 IC50 5.6 nM
CC[C@@H]1CN(C(=O)[C@@H](O)CC)CC[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)cc12 CHEMBL3667482 IC50 5.6 nM
CCOC(=O)c1c[nH]c2ncnc(-c3ccc(OC)cc3)c12 CHEMBL3703487 IC50 5.7 nM
CCOC(=O)c1c[nH]c2ncnc(-c3ccc(O)cc3)c12 CHEMBL3703495 IC50 5.7 nM
N#CCC(=O)N1CCCC12CCCN(c1ncnc3[nH]ccc13)C2 CHEMBL3689519 IC50 5.8 nM
C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 CHEMBL2386635 Ki 5.9 nM
CC1CCN(C(=O)CC#N)C12CCN(c1ncnc3[nH]ccc13)C2 CHEMBL3693601 IC50 5.9 nM
Cc1cc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)nc(C)n1 CHEMBL364623 IC50 6.0 nM
O=C1NCc2c1c1c3ccccc3n3c1c1c2c2ccccc2n1C[C@@H](O)[C@@H](O)C3 CHEMBL559787 IC50 6.0 nM
N#Cc1ccc2ncn(-c3ncc4[nH]c(=O)n(Cc5c(F)cccc5F)c4n3)c2c1 CHEMBL1079523 IC50 6.0 nM
CC1(C)[C@H](O)CC[C@H]1Nc1c(C(N)=O)cnn2cccc12 CHEMBL3359913 IC50 6.0 nM
CCOC(=O)c1c[nH]c2ncnc(C3=CCCCC3)c12 CHEMBL3703490 IC50 6.0 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(NS(C)(=O)=O)cc23)CC[C@@]1(C)O CHEMBL3671832 IC50 6.0 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccccc4C(N)=O)cc23)CC[C@]1(C)N CHEMBL3671808 IC50 6.0 nM
N#CNC1CCc2ccc(-c3ncnc4[nH]ccc34)cc21 CHEMBL4292010 IC50 6.0 nM
C[C@H]1Cc2ccc(-c3ncnc4[nH]ccc34)cc2[C@@H]1NC#N CHEMBL4278647 IC50 6.0 nM
CCC(=O)N1CCN(c2ccc([N+](=O)[O-])c(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c2)CC1 CHEMBL4541648 IC50 6.0 nM
C[C@H](c1ccc(F)cn1)n1c(=O)[nH]c2cnc(Nc3cc(F)c[nH]c3=O)nc21 CHEMBL4517586 IC50 6.0 nM
Cc1ccc(-c2cc3c(NC4C5CC6CC4CC(O)(C6)C5)c(C(N)=O)cnn3c2)cc1 CHEMBL3671803 IC50 6.1 nM
Cc1ccncc1-c1cc2c(N[C@@H]3CC[C@](C)(N)C3(C)C)c(C(N)=O)cnn2c1 CHEMBL3671805 IC50 6.1 nM
C/C=C/C(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL4750184 IC50 6.1 nM
C=CC(=O)Nc1cccc(CNc2nc(NC)nc(Nc3cc(C(C)(C)C)[nH]n3)n2)c1 CHEMBL5192697 IC50 6.16 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3cc(F)c(OCCN4CCOCC4)c(F)c3)ncc2Cl)c1 CHEMBL3601238 IC50 6.2 nM
Cn1nccc1-c1cc2c(NC3C4CC5CC3CC(O)(C5)C4)c(C(N)=O)cnn2c1 CHEMBL3671802 IC50 6.2 nM
C=CC(=O)N1CCCC(n2nc(-c3cnn(C)c3)c3c(N)ncnc32)C1 CHEMBL4244148 IC50 6.2 nM
CN(c1ncnc2[nH]ccc12)N1CCC[C@@H](C(=O)NCC(F)(F)F)C1 CHEMBL5175536 IC50 6.2 nM
O=C1NCN([C@H]2CC[C@H](CNCC(F)(F)Br)CC2)c2c1cnc1[nH]ccc21 CHEMBL3934061 IC50 6.3 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 6.31 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 6.31 nM
CCc1cc(O)c(F)cc1-c1cc(NS(=O)(=O)CCO)c2cn[nH]c2c1 CHEMBL4543715 pIC50 6.31 nM
CCc1cc(O)c(F)cc1-c1cc(NCCNC)c2nc(N)ncc2c1 CHEMBL5076068 pIC50 6.31 nM
Clc1cnc2nc1NCc1cccc(c1)OCCOc1cccc(c1)N2 CHEMBL3694583 IC50 6.4 nM
CC(C)[C@H](C)n1cc(-c2ccn(C)n2)c2[nH]nc(N)c2c1=O CHEMBL3764030 IC50 6.4 nM
C=CC(=O)N1CCC(Nc2ccc(C(F)(F)F)c(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c2)CC1 CHEMBL4533508 IC50 6.4 nM
c1ccc(-c2c(-c3ccc(OCCN4CCCC4)cc3)[nH]c3ncnc(NCC4SCCS4)c23)cc1 CHEMBL2087875 Ki 6.5 nM
CCOC(=O)c1c[nH]c2ncnc(-c3ccc4[nH]ncc4c3)c12 CHEMBL3650979 IC50 6.5 nM
C=CC(=O)Nc1cccc(C(C)Nc2nc(Nc3ccc(N4CCN(C)CC4)cc3OC)ncc2Cl)c1 CHEMBL3601709 IC50 6.6 nM
CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NC(=O)/C(C)=C/CN(C)C)c3)c12 CHEMBL3651061 IC50 6.6 nM
CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NC(=O)/C=C/c4ccccn4)c3)c12 CHEMBL3651023 IC50 6.6 nM
N#CCC(=O)N1CCC(F)(F)C12CCN(c1ncnc3[nH]ccc13)C2 CHEMBL3693602 IC50 6.6 nM
CO[C@H]1CN(C(=O)C2(C#N)CC2)C[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccc(C#N)cc3)cc12 CHEMBL3672468 IC50 6.6 nM
O=C1NCc2nc(-c3c(F)cccc3F)cc(Nc3ccc(C(=O)N4CCCC4)cc3)c21 CHEMBL5180050 Ki 6.6 nM
COC(=O)Cn1c(=O)c2cc(OC)c(OC)cc2c2cnc3[nH]ccc3c21 CHEMBL4278842 IC50 6.65 nM
O=C(c1ccc(F)cc1)N1CCc2[nH]c(-c3n[nH]c4cc(-c5cc(F)c(O)cc5CC(F)(F)F)ccc34)nc2C1 CHEMBL3644639 IC50 6.7 nM
CC[C@@H]1CN(C(=O)CC(F)(F)F)CC[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)cc12 CHEMBL3667486 IC50 6.7 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccncc4)cc23)CC[C@]1(C)N CHEMBL4063870 IC50 6.7 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCCN4CCOCC4)c(OC)c3)ncc2Cl)c1 CHEMBL4292468 IC50 6.77 nM
CCOC(=O)c1c[nH]c2ncnc(-c3ccc(N4CCS(=O)(=O)CC4)cc3)c12 CHEMBL3650983 IC50 6.8 nM
N#CCC(=O)N1CCC(F)(F)C12CCCN(c1ncnc3[nH]ccc13)C2 CHEMBL3693603 IC50 6.8 nM
C[C@]1(F)CCC[C@H]1Nc1c(C(N)=O)cnn2cc(N3CCOC3=O)cc12 CHEMBL3671823 IC50 6.8 nM
COc1ccccc1-c1c[nH]c2ncnc(-c3ccc4cn(C)nc4c3)c12 CHEMBL3651058 IC50 6.9 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(C#N)cn2)[C@H](C)C1 CHEMBL5430795 IC50 6.93 nM
CC(=O)/C1=C/Cn2c3ccccc3c3c4c(c5c6ccccc6n(c5c32)C1)C(=O)NC4=O CHEMBL557101 IC50 7.0 nM
C[C@@H](Nc1cc(-c2c(N)nn3cccnc23)ncn1)c1ccc(F)cc1 CHEMBL583895 IC50 7.0 nM
N#Cc1ccc2ncn(-c3ncc4[nH]c(=O)n(C5CCOCC5)c4n3)c2c1 CHEMBL1080323 IC50 7.0 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)c(C#N)cc2F)n[nH]1 CHEMBL1774056 IC50 7.0 nM
CC(C)CS(=O)(=O)N1CCC[C@H](NC(=O)Nc2cnc3[nH]ccc3n2)C1 CHEMBL3335685 IC50 7.0 nM
C=CC(=O)Nc1cccc(CN2C(=O)N(C)Cc3cnc(Nc4ccc(N5CCN(C)CC5)cc4)nc32)c1 CHEMBL3601727 IC50 7.0 nM
CC[C@@H]1CN(C(=O)[C@H](C)O)CC[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccnc(OC)c3)cc12 CHEMBL3667484 IC50 7.0 nM
NC(=O)c1ccc(Nc2cc(NCc3ccccc3)c(C(N)=O)cn2)cc1 CHEMBL4060298 IC50 7.0 nM
C=CC(=O)Nc1ccc2ncn(-c3cncc(NC(C)(C)C)n3)c2c1 CHEMBL4209458 IC50 7.0 nM
N#CNC1CCOc2ccc(-c3ncnc4[nH]ccc34)cc21 CHEMBL4288201 IC50 7.0 nM
N#CN[C@H]1CCOc2ccc(-c3ncnc4[nH]ccc34)cc21 CHEMBL4284952 IC50 7.0 nM
C=CC(=O)Nc1cccc(CNc2cc(Nc3cnn(CCOC)c3)ncn2)c1 CHEMBL4574614 IC50 7.0 nM
Cc1cc(Nc2ncc(Cl)c(-c3cnn(CCC#N)c3)n2)sn1 CHEMBL5423566 IC50 7.0 nM
NC(=O)c1nnc(-c2c(F)cccc2F)cc1Nc1ccc(N2CCOCC2=O)cn1 CHEMBL5413489 IC50 7.0 nM
CC1CN(C(=O)CC#N)C12CCN(c1ncnc3[nH]ccc13)C2 CHEMBL3689518 IC50 7.1 nM
C[C@]1(F)CCC[C@H]1Nc1c(C(N)=O)cnn2cc(N3CCOCC3=O)cc12 CHEMBL3671824 IC50 7.1 nM
CC[C@@H]1CN(C(=O)C(C)(C)O)CC[C@H]1Nc1c(C(N)=O)cnn2cc(-c3ccnc(C)c3)cc12 CHEMBL3667483 IC50 7.1 nM
CCc1cc(O)ccc1-c1ccc2c(-c3nc4c([nH]3)CN(C(C)=O)CC4)n[nH]c2c1 CHEMBL4093813 IC50 7.1 nM
C[C@@H]1CCN(C(=O)C(C)(C)C#N)C[C@@H]1n1c(=O)[nH]c2cnc3[nH]ccc3c21 CHEMBL5288765 IC50 7.1 nM
CCOC(=O)c1c[nH]c2ncnc(-c3ccc4cn(C)nc4c3)c12 CHEMBL3703486 IC50 7.2 nM
C=CC(=O)Nc1cccc(CNc2cc(Nc3cnn(CCO)c3)ncn2)c1 CHEMBL4572373 IC50 7.2 nM
NC(=O)c1cnn2cc(-c3ccc4scnc4c3)cc2c1NC12CC3CC(O)(CC(O)(C3)C1)C2 CHEMBL3671818 IC50 7.3 nM
COCCn1cc(Nc2cc(NCc3cccc(NC(=O)CC#N)c3)ncn2)cn1 CHEMBL4563864 IC50 7.3 nM
C=CC(=O)Nc1cccc(CNc2nc(Nc3cc(F)c(N4CCC(O)CC4)c(F)c3)ncc2Cl)c1 CHEMBL3601237 IC50 7.4 nM
O=C(CCCCCn1cc(Nc2ncc(Cl)c(Nc3ccc(Cl)cc3)n2)cn1)NO CHEMBL4526274 IC50 7.4 nM
CCOC(=O)c1c[nH]c2ncnc(-c3ccc(-n4cccn4)cc3)c12 CHEMBL3650982 IC50 7.5 nM
CCOC(=O)c1c[nH]c2ncnc(-c3ccc(Cl)c(N)c3)c12 CHEMBL3703491 IC50 7.5 nM
CCOC(=O)c1c[nH]c2ncnc(-c3ccccc3F)c12 CHEMBL3703498 IC50 7.5 nM
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4cnc[nH]4)c23)c1 CHEMBL3651051 IC50 7.5 nM
CNC(=O)c1ccc(-c2cc3c(N[C@@H]4CN(C(=O)OC)C[C@@H]4C)c(C(N)=O)cnn3c2)cn1 CHEMBL3672457 IC50 7.5 nM
C=CC(=O)N1CCN(c2ccc(C(F)(F)F)c(C3=C(c4c[nH]c5cc(C)ccc45)C(=O)NC3=O)c2)CC1 CHEMBL4459688 IC50 7.5 nM
CCOC(=O)c1c[nH]c2ncnc(-c3cccc(C)c3)c12 CHEMBL3703502 IC50 7.6 nM
NC(=O)c1cnn2cc(-c3ccc(F)cc3)cc2c1NC1CCOCC1 CHEMBL3667453 IC50 7.6 nM
Cc1cnc(Nc2ccc(N3CCOCC3)cc2)nc1-c1cc2c(o1)CCN(C(=O)CC#N)C2 CHEMBL4590082 IC50 7.6 nM
O=C(CCCCCCn1cc(Nc2ncc(Cl)c(Nc3ccc(Cl)cc3)n2)cn1)NO CHEMBL4575813 IC50 7.6 nM
CC(C)[C@H](C)NC(=O)c1c[nH]c2ncc(C3CC3)nc12 CHEMBL2325899 IC50 7.8 nM
C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CCC#N)CC1 CHEMBL2386636 Ki 7.8 nM
C=C(C)C(=O)Nc1cccc(CNc2nc(Nc3cnn(CCOC)c3)ncc2Cl)c1 CHEMBL3601123 IC50 7.8 nM
CC[C@@H]1CN(C(=O)[C@@H](C)O)CC[C@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)cc12 CHEMBL3672450 IC50 7.8 nM
C=CC(=O)Nc1ccc(CNc2cc(Nc3ccc(N4CCN(C)CC4)cc3)ncn2)cc1 CHEMBL4577029 IC50 7.9 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(Cc4ccccc4)c3n2)c1 CHEMBL1993424 pKi 7.943 nM
Clc1cc(-c2c[nH]c3ncccc23)cc(NCc2ccccc2)n1 CHEMBL1969588 pKi 7.943 nM
CCc1cc(O)ccc1-c1cc(NS(=O)(=O)CC)c2cn[nH]c2c1 CHEMBL4551061 pIC50 7.943 nM
CCS(=O)(=O)Nc1cc(-c2ccc(O)cc2)cc2[nH]ncc12 CHEMBL4531121 pIC50 7.943 nM
COc1cc(-c2cnc3cccc(-c4cc(F)c(CN5CCS(=O)(=O)CC5)c(F)c4)c3n2)ccc1OCCCN1CCOCC1 CHEMBL4634979 pIC50 7.943 nM
O=C1NC(=O)c2c1c1c3ccccc3n3c1c1c2c2ccccc2n1CC(O)CCC3 CHEMBL565066 IC50 8.0 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cc3F)c(F)c(N3CCOCC3)n2)n[nH]1 CHEMBL2381983 IC50 8.0 nM
C[C@@H](Nc1c(C(N)=O)cnn2cccc12)C(C)(C)C CHEMBL3359907 IC50 8.0 nM
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4ncco4)c23)c1 CHEMBL3651062 IC50 8.0 nM
NC(=O)c1cnc(Nc2ccccc2)cc1N[C@H](CO)c1ccccc1 CHEMBL4080656 IC50 8.0 nM
CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL4116008 IC50 8.0 nM
CC(C)(C)CNc1c(C(N)=O)cnn2cc(-c3ccccc3)cc12 CHEMBL4461011 IC50 8.0 nM
CN(c1ncnc2[nH]ccc12)N1CCCC(C(=O)NCC#N)C1 CHEMBL5172892 IC50 8.0 nM
Cc1cc(Nc2ccc3nc(C)n([C@@H]4CCc5ccc(F)cc54)c3c2)[nH]n1 CHEMBL5282343 IC50 8.0 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL1873475 IC50 8.0 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCN(Cc2ccc(Cl)cn2)[C@@H](C)C1 CHEMBL5423944 IC50 8.05 nM
CCOC(=O)c1c[nH]c2ncnc(-c3ccc4c(F)n(C)nc4c3)c12 CHEMBL3703492 IC50 8.1 nM
CCS(=O)(=O)Nc1cc2c(N[C@@H]3CC[C@@](C)(O)C3(C)C)c(C(N)=O)cnn2c1 CHEMBL3666886 IC50 8.1 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 8.2 nM
C[C@@H](NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N1CC(C#N)C1 CHEMBL2325894 IC50 8.2 nM
C/C=C/S(=O)(=O)Nc1cccc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 CHEMBL3651033 IC50 8.2 nM
CCOC(=O)c1c[nH]c2ncnc(-c3ccc(CO)c(N)c3)c12 CHEMBL3703494 IC50 8.3 nM
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(C4CCOCC4)c23)c1 CHEMBL3651063 IC50 8.3 nM
C/C=C\C(=O)Nc1cccc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 CHEMBL3651020 IC50 8.3 nM
CCc1cc(O)ccc1-c1ccc2c(-c3nc4ccccc4[nH]3)n[nH]c2c1 CHEMBL3928932 IC50 8.3 nM
CN(c1ncnc2[nH]ccc12)N1CCCC(C(=O)NCC(F)F)C1 CHEMBL5202063 IC50 8.3 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCC(=O)N4CCOCC4)c(Cl)c3)ncc2Cl)c1 CHEMBL4286900 IC50 8.34 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(C(F)(F)F)nc2)[C@H](C)C1 CHEMBL5435417 IC50 8.39 nM
CCOC(=O)c1c[nH]c2ncnc(-c3cccc(Cl)c3)c12 CHEMBL3703496 IC50 8.4 nM
COc1ncc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)cn1 CHEMBL3671814 IC50 8.4 nM
C[C@@H]1CN(C(=O)C2(C#N)COC2)C[C@@H]1Nc1c(C(N)=O)cnn2cc(-c3cnn(C)c3)nc12 CHEMBL4110159 IC50 8.4 nM
O=c1[nH]c2cnc(-c3cnc4ccc(F)cn34)nc2n1[C@H]1CC[C@H](O)CC1 CHEMBL4467200 IC50 8.4 nM
C=CC(=O)Nc1ccc(CNc2cc(Nc3ccc(N4CCOCC4)cc3)ncn2)cc1 CHEMBL4566849 IC50 8.4 nM
CN(CC(F)(F)F)C[C@H]1CC[C@H](N2CNC(=O)c3cnc4[nH]ccc4c32)CC1 CHEMBL3930342 IC50 8.5 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCOC)cc3)ncc2F)c1 CHEMBL3301625 IC50 8.5 nM
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C1CC1 CHEMBL2325900 IC50 8.6 nM
CCNC(=O)c1ccc(-c2cc3c(N[C@@H]4CN(C(=O)C(C)(C)C#N)C[C@@H]4CC)c(C(N)=O)cnn3c2)cn1 CHEMBL3672461 IC50 8.6 nM
C[C@@H](NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N1CCC(C#N)C1 CHEMBL2325912 IC50 8.7 nM
CCOC(=O)c1c[nH]c2ncnc(-c3ccc4ccccc4c3)c12 CHEMBL3703497 IC50 8.8 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(N4CCC4=O)cc23)CC[C@]1(C)N CHEMBL3671826 IC50 8.8 nM
COc1cccc(CN2CC[C@@H](Nc3c(C(N)=O)cnc4[nH]ccc34)C[C@H]2C)c1 CHEMBL4787731 IC50 8.84 nM
COc1cccc(-c2cc3c(NC4C5CC6CC4CC(O)(C6)C5)c(C(N)=O)cnn3c2)c1 CHEMBL3671799 IC50 8.9 nM
COc1ncc(-c2cc3c(N[C@@H]4CN(C(=O)C5(C#N)CC5)C[C@@H]4CF)c(C(N)=O)cnn3c2)cn1 CHEMBL3672463 IC50 8.9 nM
COc1ccc(-c2cc3c(N[C@@H]4CN(S(C)(=O)=O)C[C@@H]4OC)c(C(N)=O)cnn3c2)cn1 CHEMBL3672469 IC50 8.9 nM
CN1CN([C@H]2CC[C@H](CNS(C)(=O)=O)CC2)c2c(cnc3[nH]ccc23)C1=O CHEMBL3919463 IC50 8.9 nM
CNc1nc(NCc2cccc(NC(=O)CCl)c2)nc(Nc2cc(C(C)(C)C)[nH]n2)n1 CHEMBL5197209 IC50 8.97 nM
O=C1NC(=O)c2c1c1c3ccccc3n3c1c1c2c2ccccc2n1C[C@@](O)(C(=O)O)[C@H](O)C3 CHEMBL550791 IC50 9.0 nM
O=C1NC(=O)c2c1c1c3ccccc3n3c1c1c2c2ccccc2n1C[C@@H](O)[C@@H](O)CC3 CHEMBL557846 IC50 9.0 nM
COc1cc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)ccc1C(=O)NCC#N CHEMBL1078364 IC50 9.0 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cc3)c(C#N)cc2F)n[nH]1 CHEMBL1774055 IC50 9.0 nM
CCOC(=O)c1c[nH]c2ncnc(-c3cccc(F)c3)c12 CHEMBL3703499 IC50 9.0 nM
CCCOC(=O)c1c[nH]c2ncnc(-c3ccc4cn(C)nc4c3)c12 CHEMBL3650984 IC50 9.0 nM
CN(CC(F)(F)F)C[C@H]1CC[C@H](N2CN(C)C(=O)c3cnc4[nH]ccc4c32)CC1 CHEMBL3892444 IC50 9.0 nM
NC(=O)c1cnc(Nc2ccc3[nH]ncc3c2)cc1NCc1ccccc1 CHEMBL4088523 IC50 9.0 nM
N#CCNC(=O)c1ccc(-c2nc(Nc3ccc(N4CCC(N5CCOCC5)CC4)cc3)ncc2Cl)cc1 CHEMBL5189266 IC50 9.0 nM
O=C(OCCn1c([N+](=O)[O-])cnc1/C=C/c1ccc(Cl)cc1Cl)c1ccc2c(c1)OCCO2 CHEMBL5267576 IC50 9.0 nM
C=CC(=O)Nc1ccc(-c2ccnc(Nc3cnn(CCOC)c3)n2)cc1 CHEMBL4780984 IC50 9.1 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(C(F)(F)F)cn2)[C@H](C)C1 CHEMBL5410919 IC50 9.11 nM
NC(=O)c1cnc2[nH]ccc2c1NC1CCN(c2ccc(CO)cn2)CC1 CHEMBL3593774 IC50 9.2 nM
CCOC(=O)c1c[nH]c2ncnc(-c3cccc(Nc4nc(Cl)ns4)c3)c12 CHEMBL3651031 IC50 9.2 nM
Clc1cnc2nc1NCc1cccc(c1)OCCc1cccc(c1)N2 CHEMBL3694578 IC50 9.2 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2cccc(Cl)c2)C[C@H]1F CHEMBL4777200 IC50 9.24 nM
CNC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCN(Cc2ccc(C(F)(F)F)cc2)[C@@H](C)C1 CHEMBL5397297 IC50 9.24 nM
C=CC(=O)Nc1ccc(CNc2cc(Nc3cnn(CCOC)c3)ncn2)cc1 CHEMBL4593058 IC50 9.3 nM
CC1(C)[C@@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(C#N)cc4)cc23)CC[C@@]1(C)N CHEMBL3666891 IC50 9.4 nM
C=CC(=O)Nc1ccc(CNc2cc(Nc3cnn(CCO)c3)ncn2)cc1 CHEMBL4541547 IC50 9.4 nM
CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(N5CCCC5)nc4)cc23)CC[C@]1(C)N CHEMBL3671806 IC50 9.5 nM
CN(C[C@H]1CC[C@H](N2CN(C3CC3)C(=O)c3cnc4[nH]ccc4c32)CC1)S(C)(=O)=O CHEMBL3898972 IC50 9.5 nM
CC[C@H](C)NC(=O)c1c[nH]c2ncc(C3CC3)nc12 CHEMBL2325902 IC50 9.6 nM
CCOC(=O)c1c[nH]c2ncnc(-c3ccc4cc[nH]c4c3)c12 CHEMBL3650981 IC50 9.7 nM
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4cccnc4)c23)c1 CHEMBL3651052 IC50 9.7 nM
CS(=O)(=O)N1C[C@H](CF)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(C(F)(F)F)nc4)cc23)C1 CHEMBL3672475 IC50 9.7 nM
Clc1ncc(CN2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)s1 CHEMBL3912553 IC50 9.8 nM
C=CC(=O)Nc1cccc(Cn2c(=O)ccc3cnc(Nc4ccc(N5CCN(C)CC5)cc4OCC)nc32)c1 CHEMBL5181254 IC50 9.8 nM
C=CC(=O)N1CCC(n2nc(-c3cnn(C)c3)c3c(N)ncnc32)C1 CHEMBL4249310 IC50 9.9 nM
COc1cc2c(=O)n(CC(=O)OC(C)(C)C)c3c4cc[nH]c4ncc3c2cc1OC CHEMBL4285332 IC50 9.94 nM
C[C@@H]1C[C@H](Nc2c(C(N)=O)cnc3[nH]ccc23)CCN1Cc1cccc(Cl)c1 CHEMBL4785998 IC50 9.94 nM