COc1ccc2nc(-c3cccs3)nc(NN3C(=O)C=C(C)C3=O)c2c1 CHEMBL337665 IC50 3.0 nM
COc1cccc2nc(-c3cccs3)nc(NN3C(=O)C=C(C)C3=O)c12 CHEMBL129857 IC50 8.0 nM
Cc1nc(Cl)ncc1C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL132495 IC50 20.0 nM
Cc1ccc(-c2cccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc23)cn1 CHEMBL1761563 IC50 20.0 nM
CCOC(=O)c1cnc(-c2cccs2)nc1NN1C(=O)C=C(C)C1=O CHEMBL43549 IC50 20.0 nM
CCC(C)C(=O)O[C@H]1C(=O)O[C@@H]2C[C@H]3C(C)=CC(=O)[C@@H](O)[C@]3(C)[C@H]3[C@]4(O)OC[C@]32[C@@H]1[C@@H](C)[C@H]4O CHEMBL487194 IC50 32.0 nM
CCOC(=O)c1cnc(N(C)N2C(=O)C=C(C)C2=O)nc1CC CHEMBL85822 IC50 35.0 nM
CC[C@](C)(O)C(=O)O[C@H]1C(=O)O[C@@H]2C[C@H]3C(C)=CC(=O)[C@@H](O)[C@]3(C)[C@H]3[C@@]4(O)OC[C@]32[C@@H]1[C@@H](C)[C@H]4O CHEMBL458347 IC50 40.0 nM
Cc1ccc(-c2ncn(-c3ccc(Nc4ncc5ccc(-c6cn[nH]c6)cc5n4)cc3)n2)cn1 CHEMBL1761561 IC50 40.0 nM
Cn1cc(-c2ccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc3c2-c2cnn(C)c2)cn1 CHEMBL1761582 IC50 40.0 nM
Cn1cc(-c2ccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc3c2-c2ccccc2)cn1 CHEMBL1761583 IC50 40.0 nM
CCOC(=O)c1cnc(NN2C(=O)C=C(C)C2=O)nc1-c1ccc(C)s1 CHEMBL86615 IC50 45.0 nM
O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(Cl)nc1C(F)(F)F CHEMBL336546 IC50 50.0 nM
COc1c(-c2cnn(C)c2)ccc2cnc(Nc3ccc(-n4cnc(N5CCOCC5)n4)cc3)nc12 CHEMBL1761584 IC50 50.0 nM
COc1ccc2c3c(c4cc(OC)c(O)cc4c2c1)CN1CCC[C@H]1[C@H]3O CHEMBL250854 IC50 65.0 nM
COc1ccc2c3c(c4cc(OC)c(O)cc4c2c1)CN1CCC[C@@H]1C3 CHEMBL250474 IC50 68.0 nM
CC(C)=CC(=O)O[C@@H]1[C@H]2C(C)=C[C@H](O)[C@@H](O)[C@]2(C)[C@H]2[C@]3(O)OC[C@@]24[C@@H]1OC(=O)C[C@H]4[C@@H](C)[C@H]3O CHEMBL564009 IC50 71.0 nM
CC1=CC(=O)N(Nc2ncc(C(=O)c3ccccc3)c(C(F)(F)F)n2)C1=O CHEMBL315804 IC50 98.0 nM
O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(F)nc1C(F)(F)F CHEMBL131006 IC50 100.0 nM
Cn1cc(-c2ccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc3c2Cl)cn1 CHEMBL1761577 IC50 100.0 nM
CCOC(=O)c1cnc(-c2ccccc2)nc1NN1C(=O)C=C(C)C1=O CHEMBL42952 IC50 100.0 nM
O=C1Nc2cc(C(F)(F)F)ccc2Sc2nc(Cl)ncc21 CHEMBL3341912 IC50 100.0 nM
COc1ccc2c3c(c4cc(OC)c(OC)cc4c2c1)CN1CCC[C@H]1[C@@H]3O CHEMBL398325 IC50 110.0 nM
c1cc(-n2cnc(N3CCOCC3)n2)ccc1Nc1ncc2ccc(-c3cn[nH]c3)cc2n1 CHEMBL1761555 IC50 120.0 nM
Cn1cc(-c2ccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc3c2C2CC2)cn1 CHEMBL1761581 IC50 130.0 nM
COC1=C(C)[C@@H]2CC(=O)O[C@@H]3C[C@H]4[C@H](C)[C@@H](O)[C@H](O)C(=O)[C@]4(C)[C@@H](C1=O)[C@@]32C CHEMBL1807644 EC50 130.0 nM
Cc1c(-c2cnn(C)c2)ccc2cnc(Nc3ccc(-n4cnc(N5CCOCC5)n4)cc3)nc12 CHEMBL1761579 IC50 160.0 nM
O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(Cl)nc1Cl CHEMBL340779 IC50 200.0 nM
Cc1ncn(-c2ccc(Nc3ncc4cccc(-c5nccs5)c4n3)cc2)n1 CHEMBL1761569 IC50 200.0 nM
CC1=CC(=O)N(Nc2ncc(C(=O)OC(C)(C)C)c(C(F)(F)F)n2)C1=O CHEMBL87274 IC50 210.0 nM
COc1ccc(-c2cccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc23)cc1F CHEMBL1761565 IC50 250.0 nM
Cn1cc(-c2ccc3cnc(Nc4ccc(-n5cnc(-c6ccccn6)n5)cc4)nc3c2)cn1 CHEMBL1761562 IC50 290.0 nM
CCc1nc(Cl)ncc1C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL339462 IC50 300.0 nM
O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(Cl)nc1 CHEMBL337656 IC50 300.0 nM
CCOC(=O)c1cnc(N(C)N2C(=O)C=C(C)C2=O)nc1C(F)(F)F CHEMBL87433 IC50 300.0 nM
Cn1cc(-c2ccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc3c2)cn1 CHEMBL1761554 IC50 310.0 nM
CCOc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1C#N CHEMBL424872 EC50 318.0 nM
Cn1cc(-c2cccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc23)cn1 CHEMBL1761564 IC50 330.0 nM
O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(Cl)nc1-c1ccccc1 CHEMBL423150 IC50 400.0 nM
CCOC(=O)c1cnc(NN2C(=O)C=C(C)C2=O)nc1CC CHEMBL83026 IC50 400.0 nM
CCCc1nc(Cl)ncc1C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL262514 IC50 500.0 nM
COc1ccc(-c2cccc3cnc(Nc4ccc(-n5cnc(C)n5)cc4)nc23)cc1F CHEMBL1761568 IC50 500.0 nM
Cc1nc(Cl)ncc1C(=O)Nc1cc(Cl)cc(Cl)c1 CHEMBL3341901 IC50 500.0 nM
CNc1nc(-c2ccccc2)c(-c2nc3ccccc3c(=O)n2-c2ccccc2OC)s1 CHEMBL3341956 IC50 500.0 nM
O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(Cl)nc1C(F)(F)C(F)(F)F CHEMBL421280 IC50 600.0 nM
CC(C)n1cc(-c2ccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc3c2Cl)cn1 CHEMBL1761578 IC50 620.0 nM
Cc1ccc(-c2cccc3cnc(Nc4ccc5c(c4)OCO5)nc23)cn1 CHEMBL1761572 IC50 630.0 nM
CCNC(=O)N1CCC(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)CC1 CHEMBL248176 IC50 704.0 nM
CN(C)C(=O)N1CCC(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)CC1 CHEMBL393659 IC50 741.0 nM
CC1=CC(=O)N(Nc2ncc(-c3coc(C)n3)c(-c3cccs3)n2)C1=O CHEMBL3341914 IC50 760.0 nM
CC1CCN(NC(=O)N2CCC(Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)CC2)CC1 CHEMBL245935 IC50 807.0 nM
CC1CCN(C(=O)N2CCC(Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)CC2)CC1 CHEMBL245733 IC50 813.0 nM
CCc1nc(NN2C(=O)C=C(C)C2=O)ncc1-c1coc(C)n1 CHEMBL3341913 IC50 830.0 nM
Cc1ccc(-c2cccc3cnc(NC4CCC(O)CC4)nc23)cn1 CHEMBL1761575 IC50 930.0 nM
CCOC(=O)c1cnc(C(F)(F)F)nc1NN1C(=O)C=C(C)C1=O CHEMBL42719 IC50 1000.0 nM