CC[C@H](C)[C@@H]1NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2CSSC[C@@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(N)=O)C(=O)N2)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC1=O CHEMBL4559408 Ki 2.0 nM
CC1=C(N2CCC3(CCN(CC(O)c4ccc5c(c4Cl)COC5=O)CC3)C2=O)COC1=O CHEMBL3935296 IC50 3.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(C2=CC(=O)OC2)C3=O)ccc2c1COC2=O CHEMBL3895661 IC50 4.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(C2=C(F)C(=O)OC2)C3=O)ccc2c1COC2=O CHEMBL3967802 IC50 4.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccns2)C3=O)ccc2c1COC2=O CHEMBL4062753 IC50 4.0 nM
COc1nccc(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)n1 CHEMBL4103004 IC50 5.0 nM
CC1=C(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O CHEMBL3913475 IC50 5.0 nM
Cc1c([C@@H](O)CN2CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)CC2)ccc2c1COC2=O CHEMBL3696475 IC50 6.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(C2=C(Cl)C(=O)OC2)C3=O)ccc2c1COC2=O CHEMBL3962588 IC50 6.0 nM
CCOc1cc(-n2cc(CNC[C@H](O)c3ccc4c(c3C)COC4=O)cn2)ccc1C#N CHEMBL4548110 IC50 6.2 nM
Cc1cc(-c2ncc(CNC[C@H](O)c3ccc4c(c3C)COC4=O)s2)ccc1C#N CHEMBL4563446 IC50 6.6 nM
Cc1cc(-c2cc(CN3C[C@@H](c4ccc5c(c4C)COC5=O)N[C@@H](C)C3)on2)ncc1C#N CHEMBL4549009 IC50 6.6 nM
C[C@@H]1CC2(CCN(C[C@@H](O)c3ccc4c(c3)-c3nnnn3C4)CC2)C(=O)N1C1=CC(=O)OC1 CHEMBL3808666 IC50 7.0 nM
Cc1c([C@H](O)CN2CCC3(CC2)CCN(C2=C(F)C(=O)OC2)CC3)ccc2c1COC2=O CHEMBL5205738 IC50 7.0 nM
Cc1nsc(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)n1 CHEMBL4095422 IC50 8.0 nM
Cc1c([C@@H]2CN(Cc3ccc(-n4cc(C#N)cn4)cn3)CCN2)ccc2c1COC2=O CHEMBL4462473 IC50 8.8 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2cnc(C#N)cn2)CC3)ccc2c1COC2=O CHEMBL3622114 IC50 9.0 nM
CC1=C(N2CCC3(CCN(C[C@@H](O)c4cc5c(cc4Cl)Cn4nnnc4-5)CC3)C2=O)COC1=O CHEMBL3808614 IC50 9.0 nM
Cc1c([C@H](O)CN2CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)CC2)ccc2c1COC2=O CHEMBL3696477 IC50 9.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccc(C#N)cn2)C3)ccc2c1COC2=O CHEMBL3622105 IC50 10.0 nM
CC1=C(N2CCC3(CCN(CCc4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O CHEMBL3906183 IC50 10.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)C[C@H](C)N(C2=CC(=O)OC2)C3=O)ccc2c1COC2=O CHEMBL3893871 IC50 10.0 nM
CC1=C(N2CCCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O CHEMBL3904469 IC50 10.0 nM
CO[C@@H](CN1C2CCC1CC1(CCN(C3=C(C)C(=O)OC3)C1=O)C2)c1ccc2c(c1C)COC2=O CHEMBL3976313 IC50 10.0 nM
CC1=C(N2CCC3(CCN([C@@H](C)[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O CHEMBL3906190 IC50 10.0 nM
CC1=C(N2CCC3(CCN([C@H](C)[C@@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O CHEMBL4108107 IC50 10.0 nM
CCC1CC2(CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)CC2)C(=O)N1C1=CC(=O)OC1 CHEMBL3902424 IC50 10.0 nM
CC1=C(N2CCC3(CCN(CC(O)c4ccc5c(c4C4CC4)COC5=O)CC3)C2=O)COC1=O CHEMBL3897405 IC50 10.0 nM
CC1=C(N2CCC3(CCN(C(C)(C)C(O)c4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O CHEMBL3922034 IC50 10.0 nM
Cc1c([C@@H](O)CN2CCC3(CCCN(C4=CC(=O)OC4)C3=O)CC2)ccc2c1COC2=O CHEMBL3966873 IC50 10.0 nM
CCc1c(C(O)CN2CCC3(CC2)CCN(C2=C(C)C(=O)OC2)C3=O)ccc2c1COC2=O CHEMBL3929846 IC50 10.0 nM
CC1=C(N2CCC3(CCN(CC(O)c4ccc5c(c4F)COC5=O)CC3)C2=O)COC1=O CHEMBL3902899 IC50 10.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CC(=O)N(c2ccc(C#N)cn2)C3)ccc2c1COC2=O CHEMBL3622104 IC50 10.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2cncc(C#N)c2)C3)ccc2c1COC2=O CHEMBL4066423 IC50 10.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CC(=O)N(c2cncc(C#N)c2)C3)ccc2c1COC2=O CHEMBL4079335 IC50 10.0 nM
Cc1cc(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2)cnc1C#N CHEMBL3622112 IC50 10.1 nM
CC1=C(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4)-c4nnnn4C5)CC3)C2=O)COC1=O CHEMBL3808611 IC50 11.0 nM
Cc1c([C@@H](O)CN2CCC3(CCCN3C[C@H](O)c3ccc4c(c3C)COC4=O)C2)ccc2c1COC2=O CHEMBL3921305 IC50 11.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccncc2)C3=O)ccc2c1COC2=O CHEMBL4092262 IC50 11.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(C2=CC(=O)CC2)C3=O)ccc2c1COC2=O CHEMBL5080394 IC50 11.0 nM
Cc1nc(C(O)CN2CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)CC2)ccc1C#N CHEMBL3612814 IC50 12.0 nM
Cc1c(CCN2CCC3(CC2)CC(=O)N(c2ccc(C#N)cn2)C3)ccc2c1COC2=O CHEMBL3622106 IC50 12.0 nM
Cc1c(CCN2CCN(CC(C)c3ccc4c(c3C)COC4=O)CC2)ccc2c1COC2=O CHEMBL3663635 IC50 12.0 nM
Cc1cc(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)sn1 CHEMBL4075906 IC50 12.0 nM
Cc1c([C@H](O)CN2CCN(C[C@@H](O)c3ccc4c(c3C)COC4=O)CC2)ccc2c1COC2=O CHEMBL3696476 IC50 12.0 nM
[2H]C([2H])([2H])Oc1cc(C(O)CN2CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)CC2)ncc1C#N CHEMBL3612928 IC50 13.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccc(C#N)nn2)CC3)ccc2c1COC2=O CHEMBL3622115 IC50 13.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ncc(C#N)cn2)CC3)ccc2c1COC2=O CHEMBL3622113 IC50 14.0 nM
Cc1c([C@@H](N)CN2CCC3(CC2)CC(=O)N(c2ccc(C#N)cn2)C3)ccc2c1COC2=O CHEMBL3622111 IC50 14.0 nM
Cc1nc(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2)ccc1C#N CHEMBL3622107 IC50 14.0 nM
C[C@H]1CC2(CCN(C[C@@H](O)c3ccc4c(c3)-c3nnnn3C4)CC2)C(=O)N1C1=CC(=O)OC1 CHEMBL3808836 IC50 14.0 nM
Cc1c([C@@H](O)CN2CCN(C[C@@H](O)c3ccc(-n4cnnn4)nc3)CC2)ccc2c1COC2=O CHEMBL4106465 IC50 14.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccc(C#N)cc2)C3)ccc2c1COC2=O CHEMBL3622110 IC50 15.0 nM
Cc1c(C(O)CN2CCN(CC(O)c3ccc4c(c3C)COC4=O)CC2)ccc2c1COC2=O CHEMBL4559965 IC50 15.0 nM
CC1=C(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)CCC1=O CHEMBL5085300 IC50 15.0 nM
Cc1cc(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2)ncc1C#N CHEMBL3622108 IC50 17.0 nM
CC1=C(N2CCC3(CCN(C[C@H](O)c4cc5c(cc4C)Cn4nnnc4-5)CC3)C2=O)COC1=O CHEMBL3808714 IC50 17.0 nM
Cc1c(CCN2CCN(CCc3ccc(C#N)c(F)c3Cl)CC2)ccc2c1COC2=O CHEMBL3663633 IC50 17.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccc(=O)n(C)n2)C3=O)ccc2c1COC2=O CHEMBL4069245 IC50 17.0 nM
COc1nsc(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)n1 CHEMBL4075319 IC50 17.0 nM
Cc1c([C@@H](O)CN2CCN(C[C@H](O)c3ccc4c(c3)C[C@@H](C)OC4=O)CC2)ccc2c1COC2=O CHEMBL4113065 IC50 17.5 nM
Cc1c([C@@H](O)CN2CCN(C[C@H](O)c3ccc(C#N)cn3)CC2)ccc2c1COC2=O CHEMBL3612807 IC50 18.0 nM
Cc1c([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@H]3CO2)ccc(F)c1C#N CHEMBL3964482 IC50 18.0 nM
COc1cc(C(O)CN2CCN(CC(O)c3ccc4c(c3)C[C@@H](C)OC4=O)CC2)ncc1C#N CHEMBL4109160 IC50 18.0 nM
CCC1=C(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O CHEMBL5078395 IC50 18.0 nM
CC1=C(N2C(=O)C3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)CC2C)COC1=O CHEMBL3940633 IC50 18.0 nM
CC1=C(N2CCC3(CCN(C[C@@H](O)c4ccc5c(c4)-c4nnnn4C5)CC3)C2=O)COC1=O CHEMBL3810281 IC50 19.0 nM
Cc1cc(C#N)cnc1N1CCC2(CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)CC2)C1 CHEMBL3622109 IC50 20.0 nM
Cc1c(CCN2CCN(C(=O)Cc3ccc(-n4cnnn4)nc3)CC2)ccc2c1COC2=O CHEMBL3692706 IC50 20.0 nM
C[C@H]1CC2(CCN(C[C@H](O)c3ccc4c(c3)-c3nnnn3C4)CC2)C(=O)N1C1=CC(=O)OC1 CHEMBL3810197 IC50 20.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)C[C@@H](C)N(C2=CC(=O)OC2)C3=O)ccc2c1COC2=O CHEMBL4114084 IC50 20.0 nM
CC1=C(N2C(=O)C3(CCN(C[C@@H](O)c4ccc5c(c4C)COC5=O)CC3)CC2C)COC1=O CHEMBL4110200 IC50 20.0 nM
CC1=C(N2CCC3(CCN(C[C@H](O)c4cc5c(cc4C)C(=O)OC5)CC3)C2=O)COC1=O CHEMBL3901468 IC50 20.0 nM
Cc1c([C@@H](O)CN2C3CCC2CC2(CC(C)N(C4=CC(=O)OC4)C2=O)C3)ccc2c1COC2=O CHEMBL3924649 IC50 20.0 nM
Cc1c([C@H](O)CN2C3CCC2CC2(CC(C)N(C4=CC(=O)OC4)C2=O)C3)ccc2c1COC2=O CHEMBL4108052 IC50 20.0 nM
CC1=C(N2CCC3(CCN(C[C@@H](F)c4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O CHEMBL4112984 IC50 20.0 nM
CCC1CC2(CCN(C[C@@H](O)c3ccc4c(c3C)COC4=O)CC2)C(=O)N1C1=CC(=O)OC1 CHEMBL4112308 IC50 20.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CC(C2CC2)N(C2=CC(=O)OC2)C3=O)ccc2c1COC2=O CHEMBL3962455 IC50 20.0 nM
CO[C@@H](CN1CCC2(CC1)CCN(C1=CC(=O)OC1C)C2=O)c1ccc2c(c1C)COC2=O CHEMBL3891230 IC50 20.0 nM
CCC1=C(N2CCC3(CCN(C[C@H](OC)c4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O CHEMBL3923794 IC50 20.0 nM
CO[C@@H](CN1CCC2(CC1)CCN(C1=CC(=O)OC1)C2=O)c1ccc2c(c1C)COC2=O CHEMBL3891643 IC50 20.0 nM
[C-]#[N+]c1cc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)ccc1F CHEMBL3959750 IC50 20.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2cnsc2)C3=O)ccc2c1COC2=O CHEMBL4086822 IC50 20.0 nM
COc1cc(C(O)CN2C3CCC2C2CCC3N2C[C@H](O)c2ccc3c(c2C)COC3=O)ncc1C#N CHEMBL3915907 IC50 21.0 nM
Cc1c([C@@H](O)CN2CCN(CCc3ccc4c(c3)CCOC4=O)CC2)ccc2c1COC2=O CHEMBL3915018 IC50 21.0 nM
O=[N+]([O-])c1ccc(CCN2CCN(CCc3ccc([N+](=O)[O-])cc3)CC2)cc1 CHEMBL2146755 IC50 24.0 nM
CCOc1cc(C(O)CN2CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)CC2)ncc1C#N CHEMBL3612926 IC50 24.0 nM
Cc1nc(-n2cnnn2)ccc1[C@H](O)CN1CCN(C[C@H](O)c2ccc3c(c2C)COC3=O)CC1 CHEMBL3895051 IC50 24.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(C2=CC(=O)OC2C)C3=O)ccc2c1COC2=O CHEMBL5084415 IC50 24.0 nM
O=C1OCc2cc(CCN3CCN(CCc4ccc5c(c4)COC5=O)CC3)ccc21 CHEMBL2146870 IC50 26.0 nM
Cc1c(C(F)CN2CCN(C(=O)Cc3ccc(-n4cnnn4)nc3)CC2)ccc2c1COC2=O CHEMBL3792978 IC50 26.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(C2=CC(=O)OC2)C3)ccc2c1COC2=O CHEMBL5085209 IC50 26.0 nM
COc1cc([C@@H](O)CN2CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)CC2)ncc1C#N CHEMBL3612810 IC50 27.0 nM
Cc1c(C#N)cccc1[C@@H]1CN2CCN(C(=O)Cc3ccc(-n4cnnn4)nc3)C[C@@H]2CO1 CHEMBL3964139 IC50 27.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccns2)C3)ccc2c1COC2=O CHEMBL4059846 IC50 27.0 nM
Cc1c(CCN2CCc3c(cnn3-c3ccc(C#N)c(F)c3)C2)ccc2c1COC2=O CHEMBL3914024 IC50 27.46 nM
Cc1c(C(O)CN2CCc3nc(-n4cc(C#N)c5ccccc54)ncc3C2)ccc2c1COC2=O CHEMBL4465260 IC50 28.0 nM
O=C1OCc2cc(CCN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)CC3)ccc21 CHEMBL3794155 IC50 29.0 nM
Cc1cc(-n2cnnn2)ncc1[C@@H](O)CN1CCN(C[C@H](O)c2ccc3c(c2C)COC3=O)CC1 CHEMBL3954047 IC50 29.0 nM
Cc1c([C@@H](O)CN2CCN(C[C@@H](O)c3ccc4c(c3)C[C@@H](C)OC4=O)CC2)ccc2c1COC2=O CHEMBL4114504 IC50 29.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccc(S(C)(=O)=O)cn2)C3)ccc2c1COC2=O CHEMBL4098260 IC50 29.0 nM
[C-]#[N+]c1ccc(C(O)CN2C3COCC2CN(C[C@H](O)c2ccc4c(c2C)COC4=O)C3)nc1 CHEMBL3946181 IC50 29.5 nM
N#Cc1ccc(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)cc1F CHEMBL2146873 IC50 30.0 nM
Cc1c([C@@H](O)CN2CC3COCC(C2)N3C[C@H](O)c2ccc3c(c2C)COC3=O)ccc2c1COC2=O CHEMBL3975216 IC50 30.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CC(C)N(C2=CC(=O)OC2)C3=O)ccc2c1COC2=O CHEMBL3918213 IC50 30.0 nM
CC1=C(N2CCC3(CCN(C[C@@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O CHEMBL4109988 IC50 30.0 nM
CC1=C(N2CC(=O)C3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O CHEMBL3961509 IC50 30.0 nM
CC1=C(N2CCC3(CCN(C[C@@H](O)c4cc5c(cc4C)C(=O)OC5)CC3)C2=O)COC1=O CHEMBL4110777 IC50 30.0 nM
CC1=C(N2C=CC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O CHEMBL3938047 IC50 30.0 nM
CCO[C@@H](CN1CCC2(CC1)CCN(C1=C(C)C(=O)OC1)C2=O)c1ccc2c(c1C)COC2=O CHEMBL3916760 IC50 30.0 nM
CC1=CC2(CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)CC2)C(=O)N1C1=CC(=O)OC1 CHEMBL3921543 IC50 30.0 nM
CO[C@@H](CN1CCC2(CC1)CCN(C1=CC(=O)OC1)C2)c1ccc2c(c1C)COC2=O CHEMBL3975315 IC50 30.0 nM
CO[C@H](CN1CCC2(CC1)CCN(C1=CC(=O)OC1C)C2=O)c1ccc2c(c1C)COC2=O CHEMBL4113270 IC50 30.0 nM
[C-]#[N+]c1c(F)ccc(C2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)CC3CO2)c1C CHEMBL3890000 IC50 30.0 nM
CC1=C(N2CCC3(CCN(C[C@H](O)c4cc5c(cc4Cl)Cn4nnnc4-5)CC3)C2=O)COC1=O CHEMBL3809742 IC50 31.0 nM
Cc1c([C@@H](O)CN2CCCC3(CCCN(C(=O)c4ccc(-n5cnnn5)nc4)C3)C2)ccc2c1COC2=O CHEMBL3966034 IC50 31.0 nM
Cc1c([C@@H](O)CN2CCN(C[C@@H](O)c3ccc4c(c3)C[C@H](C)OC4=O)CC2)ccc2c1COC2=O CHEMBL3919535 IC50 31.5 nM
Cc1noc(CNC(=O)c2ccc(C)c(S(=O)(=O)Nc3ccc(-c4cnco4)cc3)c2)n1 CHEMBL4172084 pIC50 31.62 nM
C[C@@H]1CC2(CCN(C[C@H](O)c3ccc4c(c3)-c3nnnn3C4)CC2)C(=O)N1C1=CC(=O)OC1 CHEMBL3809005 IC50 32.0 nM
Cc1c([C@@H](O)CN2C3COCC2CN(CCc2ccc4c(c2)C[C@H](C)OC4=O)C3)ccc2c1COC2=O CHEMBL3916282 IC50 32.0 nM
Cc1cc(-n2cnnn2)ncc1[C@H](O)CN1CCN(C[C@H](O)c2ccc3c(c2C)COC3=O)CC1 CHEMBL3968305 IC50 32.5 nM
Cc1c([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)cn4)C[C@H]3CO2)ccc(F)c1C#N CHEMBL3974889 IC50 33.0 nM
Cc1c([C@@H](O)CN2CCN(CCc3ccc4c(c3)C[C@@H](C)OC4=O)CC2)ccc2c1COC2=O CHEMBL4111169 IC50 33.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CC(=O)N(c2cnc(S(C)(=O)=O)cn2)C3)ccc2c1COC2=O CHEMBL4086237 IC50 34.0 nM
Cc1c(CCN2CCN(CC(O)c3ccc4c(c3C)COC4=O)CC2)ccc2c1COC2=O CHEMBL3696479 IC50 34.0 nM
COc1cc(CCN2CCN(CCc3ccc4c(c3C)COC4=O)CC2)ccc1C#N CHEMBL3612796 IC50 35.0 nM
CC1=C(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4)-c4nnnn4C5)C[C@@H]3F)C2=O)COC1=O CHEMBL3810184 IC50 35.0 nM
Cc1c([C@@H](O)CN2CCN(C[C@H](O)c3ccc(-n4cnnn4)nc3)CC2)ccc2c1COC2=O CHEMBL3926414 IC50 35.0 nM
Cc1c([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)ccc(F)c1C#N CHEMBL3911740 IC50 36.0 nM
Cc1c([C@H](O)CN2CC3CCN(C[C@@H](O)c4ccc5c(c4C)COC5=O)C3C2)ccc2c1COC2=O CHEMBL4110093 IC50 36.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2cnc(S(C)(=O)=O)cn2)C3)ccc2c1COC2=O CHEMBL4064760 IC50 37.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccc(-n4cnnn4)cn2)C3)ccc2c1COC2=O CHEMBL4062576 IC50 37.0 nM
O=C1OCc2c1ccc(CCN1CCN(C(=O)Cc3ccc(-n4cnnn4)cc3)CC1)c2F CHEMBL2441420 IC50 38.0 nM
O=C1OCCc2cc(CCN3CCN(CC(O)c4ccc5c(c4C(F)(F)F)COC5=O)CC3)ccc21 CHEMBL3948756 IC50 38.0 nM
Cc1c(C(O)CN2CCc3nc(-n4ncc5c(C#N)cccc54)ncc3C2)ccc2c1COC2=O CHEMBL4447159 IC50 38.0 nM
Cc1c([C@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@H]3CO2)ccc(F)c1C#N CHEMBL3920038 IC50 39.0 nM
Cc1c([C@@H](O)CN2C(C)CC3CN(CC(O)c4ccc(C#N)cn4)CC32)ccc2c1COC2=O CHEMBL3897788 IC50 39.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(C2=C(C4CC4)C(=O)OC2)C3=O)ccc2c1COC2=O CHEMBL3978489 IC50 40.0 nM
Cc1c([C@@H](O)CN2CCC3(C=CN(C4=CC(=O)OC4)C3=O)CC2)ccc2c1COC2=O CHEMBL3892183 IC50 40.0 nM
CC1=C(N2CCC3(CCN(C[C@H](F)c4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O CHEMBL3906586 IC50 40.0 nM
CO[C@@H](CN1CCC2(CC1)CCN(C1=C(C)C(=O)OC1)C2=O)c1ccc2c(c1C)COC2=O CHEMBL3986501 IC50 40.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)C(=O)N(C2=CC(=O)OC2)c2ccccc23)ccc2c1COC2=O CHEMBL3976581 IC50 40.0 nM
COC1CN(C[C@H](O)c2ccc3c(c2C)COC3=O)CCC12CCN(C1=C(C)C(=O)OC1)C2=O CHEMBL3911915 IC50 40.0 nM
O=C1OCc2cc([C@@H]3CN4CCN(C(=O)Cc5ccc(-n6cnnn6)nc5)C[C@H]4CO3)ccc21 CHEMBL3909199 IC50 40.0 nM
[C-]#[N+]c1scc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)c1C CHEMBL3926954 IC50 40.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@H]3CO2)c1Cl CHEMBL3908351 IC50 40.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)c1C CHEMBL3906322 IC50 40.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@H]3CO2)c1C CHEMBL3930838 IC50 40.0 nM
[C-]#[N+]c1c(F)ccc(C2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)CC3CO2)c1C CHEMBL3985014 IC50 40.0 nM
Cc1c([C@@H](O)CN2CC3CC(C)N(C[C@H](O)c4ccc5c(c4C)COC5=O)C3C2)ccc2c1COC2=O CHEMBL3929018 IC50 40.0 nM
Cc1c([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)ccc(F)c1C#N CHEMBL3924012 IC50 41.0 nM
Cc1c([C@@H](O)CN2CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)C(C)(C)C2)ccc2c1COC2=O CHEMBL3902083 IC50 41.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccc(=O)n(C4CCCC4)n2)C3=O)ccc2c1COC2=O CHEMBL4071141 IC50 41.0 nM
Cc1c([C@@H](O)[C@H](C)N2CCC3(CCN(c4ccc(=O)n(C)n4)C3=O)CC2)ccc2c1COC2=O CHEMBL4075415 IC50 42.0 nM
COc1cc(C(O)CN2CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)CC2)ccc1C#N CHEMBL3612811 IC50 43.0 nM
CC1=C(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4)-c4nnnn4C5)C[C@H]3F)C2=O)COC1=O CHEMBL3809734 IC50 43.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CC(=O)N(c2ccc(S(C)(=O)=O)cn2)C3)ccc2c1COC2=O CHEMBL4066256 IC50 43.0 nM
O=C(Cc1ccc(-n2cnnn2)nc1)N1CCN2C[C@@H](c3ccc4nonc4c3)OC[C@@H]2C1 CHEMBL3939330 IC50 45.0 nM
Cc1nc(C(O)CN2C3CCC2C2CCC3N2C[C@H](O)c2ccc3c(c2C)COC3=O)ccc1C#N CHEMBL3938464 IC50 45.0 nM
Cc1c([C@@H](O)CN2C3COCC2CN(CCc2ccc4c(c2)C[C@@H](C)OC4=O)C3)ccc2c1COC2=O CHEMBL4109569 IC50 45.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CC(=O)N(C2=CC(=O)OC2)C3)ccc2c1COC2=O CHEMBL5091929 IC50 45.0 nM
Cc1c([C@@H](O)CN2CCN(CC(O)c3cc(C4CC4)c(C#N)cn3)CC2)ccc2c1COC2=O CHEMBL3612924 IC50 46.0 nM
CCc1c(C(O)CN2CCN(CCc3ccc4c(c3)CCOC4=O)CC2)ccc2c1COC2=O CHEMBL3939978 IC50 46.0 nM
Cc1c([C@@H](O)CN2CCC3(CCCN3S(=O)(=O)c3ccc(-n4cnnn4)cc3)C2)ccc2c1COC2=O CHEMBL3890061 IC50 46.0 nM
Cc1c([C@@H](O)CN2CCC3CN(CC(O)c4ccc(C#N)cn4)CC32)ccc2c1COC2=O CHEMBL3926746 IC50 47.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccc(C#N)cn2)CC3)ccc2c1COC2=O CHEMBL4070123 IC50 47.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2cnsn2)C3=O)ccc2c1COC2=O CHEMBL4076563 IC50 47.0 nM
COc1cc(C(O)CN2CCN(CCc3ccc4c(c3C)COC4=O)CC2)ncc1C#N CHEMBL3612806 IC50 49.0 nM
Cc1c(C#N)cccc1[C@@H]1CN2CCN(C(=O)Cc3ccc(-n4cnnn4)nc3)C[C@H]2CO1 CHEMBL3913955 IC50 50.0 nM
COc1cc(F)c(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)cc1C#N CHEMBL3663634 IC50 50.0 nM
CO[C@@H](CN1CCC2(CC1)C[C@H](C)N(C1=CC(=O)OC1)C2=O)c1ccc2c(c1C)COC2=O CHEMBL3891382 IC50 50.0 nM
CC1=C(N2CCC3(CCN([C@H](C)[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O CHEMBL4108449 IC50 50.0 nM
CO[C@@H](CN1CCC2(CC1)CC(=O)N(C1=CC(=O)OC1)C2)c1ccc2c(c1C)COC2=O CHEMBL3929202 IC50 50.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)c1Cl CHEMBL3918164 IC50 50.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccc(S(C)(=O)=O)nc2)C3)ccc2c1COC2=O CHEMBL4087218 IC50 50.0 nM
Cc1c(CCN2CCC3(CC2)CCN(c2ccc(=O)n(C)n2)C3=O)ccc2c1COC2=O CHEMBL4075868 IC50 51.0 nM
[C-]#[N+]c1ccc(N2CCCC(NC[C@H](O)c3ccc4c(c3C)COC4=O)C2)nc1 CHEMBL3701214 IC50 52.0 nM
CCOc1cc(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)ccc1C#N CHEMBL2146877 IC50 53.0 nM
Cc1c([C@H](O)CN2C(C)CC3CN(CC(O)c4ccc(C#N)cn4)CC32)ccc2c1COC2=O CHEMBL4109530 IC50 53.0 nM
[C-]#[N+]c1ccc(N2CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)CC2)nc1 CHEMBL3981482 IC50 54.0 nM
Cc1c([C@@H](O)CN2C[C@H]3CC[C@@H](C2)N3S(=O)(=O)c2ccc(-n3cnnn3)cc2)ccc2c1COC2=O CHEMBL3936695 IC50 54.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2sncc2Cl)C3=O)ccc2c1COC2=O CHEMBL4071329 IC50 54.0 nM
Cc1nc(-n2cnnn2)ccc1[C@@H](O)CN1CCN(C[C@H](O)c2ccc3c(c2C)COC3=O)CC1 CHEMBL3910806 IC50 55.0 nM
COc1cc(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)ccn1 CHEMBL4071345 IC50 56.0 nM
O=C1OCCc2cc([C@@H]3CN4CCN(C(=O)Cc5ccc(-n6cnnn6)nc5)C[C@H]4CO3)ccc21 CHEMBL3889781 IC50 57.0 nM
Cc1c([C@H](O)CN2CC3CC(C)N(C[C@@H](O)c4ccc5c(c4C)COC5=O)C3C2)ccc2c1COC2=O CHEMBL4113517 IC50 57.0 nM
O=C1OCCc2cc([C@@H]3CN4CCN(C(=O)Cc5ccc(-n6cnnn6)cc5)C[C@H]4CO3)ccc21 CHEMBL3987135 IC50 57.0 nM
CNc1nccc(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)n1 CHEMBL4078730 IC50 59.0 nM
COc1cc(CCN2CCN(CC(F)c3ccc4c(c3C)COC4=O)CC2)ccc1C#N CHEMBL3612798 IC50 60.0 nM
Cc1c([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@@H]3CO2)ccc(F)c1C#N CHEMBL3943156 IC50 60.0 nM
CC1=C(N2CCC3(CCN(C(CO)Cc4ccc5c(c4C)COC5=O)CC3)C2=O)COC1 CHEMBL3975693 IC50 60.0 nM
CO[C@@H](CN1CCC2(CC1)CCN(C1=C(C)C(=O)OC1C)C2=O)c1ccc2c(c1C)COC2=O CHEMBL3937134 IC50 60.0 nM
O=C1C=C(N2CCC3(CCN(CC4OCCc5c4ccc4c5COC4=O)CC3)C2=O)CO1 CHEMBL3966510 IC50 60.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)cn4)C[C@H]3CO2)c1Cl CHEMBL3908018 IC50 60.0 nM
[C-]#[N+]c1cccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)c1C CHEMBL3964829 IC50 60.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@@H]3CO2)c1Cl CHEMBL4113192 IC50 60.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@H]3CO2)c1Cl CHEMBL3901064 IC50 60.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CN2)c1C CHEMBL4109858 IC50 60.0 nM
O=C1OCc2cc([C@H]3CN4CCN(C(=O)Cc5ccc(-n6cnnn6)nc5)C[C@H]4CO3)ccc21 CHEMBL3976314 IC50 60.0 nM
Cc1c(C#N)cccc1[C@@H]1CN2CCN(C(=O)Cc3ccc(-n4cnnn4)cc3)C[C@H]2CO1 CHEMBL4451354 IC50 60.0 nM
O=C1OCCc2cc(CCN3CCN(C(=O)Cc4ccc(-n5cnnn5)cc4)CC3)ccc21 CHEMBL2441408 IC50 61.0 nM
Cc1cc(C(O)CN2CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)CC2)ncc1C#N CHEMBL3612813 IC50 61.0 nM
COc1ccc(C(=O)NC(C)c2cnn(C)n2)cc1S(=O)(=O)Nc1ccc(Cl)cc1 CHEMBL4159883 IC50 61.0 nM
Cc1c([C@@H](O)CN2CC3CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)C3C2)ccc2c1COC2=O CHEMBL3912073 IC50 62.0 nM
Cc1c([C@@H](O)CN2CCC3CN(S(=O)(=O)c4ccc(C#N)cc4)CC32)ccc2c1COC2=O CHEMBL3938901 IC50 62.0 nM
Cc1noc(CNC(=O)c2ccc(C)c(S(=O)(=O)Nc3ccc(Cl)cc3)c2)n1 CHEMBL4174695 IC50 62.0 nM
O=C1OCc2cc(CCN3CCN(C(=O)Cc4ccc(-n5cnnn5)cc4)CC3)ccc21 CHEMBL2441437 IC50 64.0 nM
Cc1c([C@@H](O)CN2C3COCC2CN(CC(O)c2ccc4c(c2)C[C@@H](C)OC4=O)C3)ccc2c1COC2=O CHEMBL4114645 IC50 64.0 nM
Cc1c([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)ccc2c1COC2=O CHEMBL3929578 IC50 65.0 nM
[C-]#[N+]c1ccc(NCC2CCCN2C[C@H](O)c2ccc3c(c2C)COC3=O)nc1 CHEMBL3701212 IC50 65.0 nM
Cc1cnsc1N1CCC2(CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)CC2)C1=O CHEMBL4067649 IC50 65.0 nM
O=C1OCc2cc(C3CN4CCN(C(=O)Cc5ccc(-n6cnnn6)cc5)CC4CO3)ccc21 CHEMBL4544141 IC50 65.0 nM
Cc1cc(-n2cnnn2)cnc1CC(=O)N1CCN(CCc2ccc3c(c2C)COC3=O)CC1 CHEMBL3793380 IC50 66.0 nM
Cc1c(CCN2CCc3c(cnn3-c3ccc4c(c3)COC4=O)C2)ccc2c1COC2=O CHEMBL3958403 IC50 66.0 nM
Cc1c([C@@H](O)CN2C3COCC2CC(CC(O)c2ccc4c(c2)C[C@H](C)OC4=O)C3)ccc2c1COC2=O CHEMBL3932059 IC50 66.0 nM
Cc1c([C@H](O)CN2CCC3(CCCN3S(=O)(=O)c3ccc(-n4cnnn4)cc3)C2)ccc2c1COC2=O CHEMBL4113259 IC50 66.0 nM
COc1cc([C@H](O)CN2CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)CC2)ncc1C#N CHEMBL3612809 IC50 67.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccc(=O)n(C)n2)C3)ccc2c1COC2=O CHEMBL4082637 IC50 68.0 nM
Cc1c(C(F)CN2CCN(C(=O)Cc3ccc(-n4cnnn4)cc3)CC2)ccc2c1COC2=O CHEMBL4566857 IC50 69.0 nM
COc1cc(C(O)CN2CCN(CCc3ccc4c(c3C)COC4=O)CC2)ccc1C#N CHEMBL3612805 IC50 70.0 nM
Cc1c([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)cn4)C[C@H]3CO2)ccc(F)c1C#N CHEMBL3892013 IC50 70.0 nM
CC1=C(N2CC(C)C3(CCN(C[C@@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O CHEMBL4114598 IC50 70.0 nM
CC1=C(N2CCC3(CCN([C@@H](C)[C@@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O CHEMBL3897230 IC50 70.0 nM
COCC1=C(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O CHEMBL3889995 IC50 70.0 nM
O=C1C=C(N2CCC3(CCN(CCc4ccc5c(c4)COC5=O)CC3)C2=O)CO1 CHEMBL3911150 IC50 70.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)c1Cl CHEMBL3977997 IC50 70.0 nM
Cc1c([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@@H]3CO2)ccc2c1COC2=O CHEMBL3922156 IC50 70.0 nM
C[C@@H]1Cc2cc([C@H]3CN4CCN(C(=O)Cc5ccc(-n6cnnn6)nc5)CC4CO3)ccc2C(=O)O1 CHEMBL4111199 IC50 70.0 nM
[C-]#[N+]c1ccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@@H]3CO2)cc1OC CHEMBL4110397 IC50 70.0 nM
[C-]#[N+]c1ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)cc1F CHEMBL3951160 IC50 70.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4C)C[C@H]3CO2)c1F CHEMBL3902364 IC50 70.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CN2)c1C CHEMBL4107766 IC50 70.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)cn4)C[C@H]3CO2)c1C CHEMBL3893906 IC50 70.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)c1OC CHEMBL3959612 IC50 70.0 nM
Cc1cc(-n2cnnn2)ccc1CC(=O)N1CCN(CCc2ccc3c(c2)COC3=O)CC1 CHEMBL2441414 IC50 71.0 nM
[C-]#[N+]c1cnc(C(O)CN2C3COCC2CN(C[C@H](O)c2ccc4c(c2C)COC4=O)C3)cc1OC CHEMBL3983666 IC50 71.0 nM
Cc1c([C@@H](O)CN2CCN(C[C@H](O)c3ccc4c(c3)C[C@H](C)OC4=O)CC2)ccc2c1COC2=O CHEMBL3935179 IC50 71.0 nM
Cc1c(CCN2CCN(C(=O)Cc3ccc(-n4cnnn4)cc3)CC2)ccc2c1COC2=O CHEMBL2441417 IC50 72.0 nM
Cc1c([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)ccc2nonc12 CHEMBL3922938 IC50 72.0 nM
Cc1c([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)cn4)C[C@H]3CO2)ccc(F)c1C#N CHEMBL3933749 IC50 73.0 nM
Cc1c(CCN2CCc3nc(-c4ccc5c(c4)COC5=O)oc3C2)ccc2c1COC2=O CHEMBL3983850 IC50 74.74 nM
N#Cc1ccc(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)cc1Cl CHEMBL2146874 IC50 75.0 nM
Cc1c([C@H](O)CN2CCC3(CCCN3C[C@@H](O)c3ccc4c(c3C)COC4=O)C2)ccc2c1COC2=O CHEMBL4107891 IC50 76.0 nM
Cc1nc(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2)ccc1S(C)(=O)=O CHEMBL4093830 IC50 76.0 nM
Cc1c(CCN2CCN(CCc3ccc4c(c3C)COC4=O)CC2)ccc2c1COC2=O CHEMBL4534171 IC50 76.0 nM
CCn1nc(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)ccc1=O CHEMBL4093121 IC50 77.0 nM
Cc1c([C@@H](O)CN2C[C@H]3C[C@@H]2CN3C[C@H](O)c2ccc3c(c2)C[C@H](C)OC3=O)ccc2c1COC2=O CHEMBL3975707 IC50 78.0 nM
N#Cc1ccc(CCN2CCN(CCc3ccc([N+](=O)[O-])cc3)CC2)cc1 CHEMBL2146757 IC50 79.0 nM
Cc1cc(S(=O)(=O)N2CCCC23CCN(C[C@H](O)c2ccc4c(c2C)COC4=O)C3)ccc1-n1cnnn1 CHEMBL3893472 IC50 79.0 nM
CC1=CN(C2=C(C)C(=O)OC2)C(=O)C12CCN(C[C@H](O)c1ccc3c(c1C)COC3=O)CC2 CHEMBL3957402 IC50 80.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)cn4)C[C@@H]3CO2)c1C CHEMBL4108460 IC50 80.0 nM
C[C@H]1Cc2cc([C@@H]3CN4CCN(C(=O)Cc5ccc(-n6cnnn6)nc5)C[C@H]4CO3)ccc2C(=O)O1 CHEMBL3908072 IC50 80.0 nM
[C-]#[N+]c1c(OC)ccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)c1C CHEMBL3895610 IC50 80.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)c(F)c4)C[C@H]3CO2)c1C CHEMBL3954398 IC50 80.0 nM
N#Cc1ccc(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)cc1OC1CC1 CHEMBL2146879 IC50 81.0 nM
Cc1c([C@@H](O)CN2CCN3CC(c4ccc5c(c4)C[C@@H](C)OC5=O)C[C@H]3C2)ccc2c1COC2=O CHEMBL3975647 IC50 81.43 nM
Cc1c([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)ccc2nonc12 CHEMBL3891108 IC50 83.0 nM
Cc1c([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nn4)C[C@H]3CO2)ccc(F)c1C#N CHEMBL3900985 IC50 86.0 nM
Cc1ccc(C(=O)NCc2cn(C)nn2)cc1S(=O)(=O)Nc1ccc(Cl)cc1 CHEMBL4175004 IC50 86.0 nM
Cc1c([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)ccc2c1COC2=O CHEMBL3900159 IC50 88.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CN(c2ccc(=O)n(C)n2)CCO3)ccc2c1COC2=O CHEMBL4062796 IC50 88.0 nM
O=C1OCc2c1cccc2-c1ccc(CCN2CCN(CCc3ccc([N+](=O)[O-])cc3)CC2)cc1 CHEMBL2146856 IC50 89.0 nM
COc1cc(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)ccc1C#N CHEMBL2146876 IC50 89.0 nM
O=C1OCc2cc(CCN3CCN(CCc4ccc([N+](=O)[O-])cc4)CC3)ccc21 CHEMBL3612795 IC50 89.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccc(C#N)nc2)C3)ccc2c1COC2=O CHEMBL4097359 IC50 89.0 nM
CC1=C(N2CC(C)C3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O CHEMBL3904677 IC50 90.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)cn4)C[C@H]3CO2)c1C CHEMBL3921897 IC50 90.0 nM
[C-]#[N+]c1c(F)ccc(C2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)CC3CO2)c1F CHEMBL3922492 IC50 90.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)cc4C)C[C@H]3CO2)c1C CHEMBL3904037 IC50 90.0 nM
O=C1OCc2c1ccc([C@H]1CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO1)c2Cl CHEMBL3952700 IC50 90.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@@H]3CO2)c1F CHEMBL4114896 IC50 90.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)c(C)n4)C[C@H]3CO2)c1C CHEMBL3945202 IC50 90.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)c(F)c4)C[C@@H]3CO2)c1C CHEMBL4108434 IC50 90.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4C)C[C@H]3CO2)c1C CHEMBL3923225 IC50 90.0 nM
Cc1c([C@H](O)CN2CCCC3(CCCN(C(=O)c4ccc(-n5cnnn5)nc4)C3)C2)ccc2c1COC2=O CHEMBL4107055 IC50 94.0 nM
Cc1c(C(C)CN2CCN(C(=O)Cc3ccc(-n4cnnn4)nc3)CC2)ccc2c1COC2=O CHEMBL3794292 IC50 95.0 nM
Cc1c([C@@H](O)CN2CCN(C[C@@H](O)c3ccc4c(c3)CCS4(=O)=O)CC2)ccc2c1COC2=O CHEMBL4114555 IC50 95.0 nM
Cc1c([C@@H](O)CN2CCN(C[C@H](O)c3ccc4c(c3)CCS4(=O)=O)CC2)ccc2c1COC2=O CHEMBL3967230 IC50 95.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CC(=O)N(c2ccc(=O)n(C)n2)C3)ccc2c1COC2=O CHEMBL4059965 IC50 95.0 nM
Cc1c(C(F)CN2CCN(CC(F)c3ccc4c(c3C)COC4=O)CC2)ccc2c1COC2=O CHEMBL4573466 IC50 96.0 nM
CC1=C(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)C(C)OC1=O CHEMBL5077809 IC50 98.0 nM
N#Cc1ccc(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)cc1Br CHEMBL2146875 IC50 99.0 nM
Cc1c([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CS2)ccc2c1COC2=O CHEMBL3921834 IC50 100.0 nM
CNC(CN1CCC2(CC1)CCN(C1=C(C)C(=O)OC1)C2=O)c1ccc2c(c1C)COC2=O CHEMBL3956491 IC50 100.0 nM
CO[C@H](CN1CCC2(CC1)CCN(C1=C(C)C(=O)OC1C)C2=O)c1ccc2c(c1C)COC2=O CHEMBL4111715 IC50 100.0 nM
O=C1OCc2cc([C@@H]3CN4CCN(C(=O)Cc5ccc(-n6cnnn6)cn5)C[C@H]4CO3)ccc21 CHEMBL3914553 IC50 100.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)cn4)C[C@H]3CO2)c1F CHEMBL3981572 IC50 100.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4C)C[C@H]3CO2)c1C CHEMBL3938189 IC50 100.0 nM
[C-]#[N+]c1cc([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@H]3CO2)ccc1F CHEMBL3943437 IC50 100.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@H]3CN2)c1C CHEMBL4108822 IC50 100.0 nM
Cc1noc(CNC(=O)c2ccc(C)c(S(=O)(=O)Nc3ccc(-c4ccno4)cc3)c2)n1 CHEMBL4166791 pIC50 100.0 nM
[C-]#[N+]c1ccc(NCC2(C)CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)C2)nc1 CHEMBL3701215 IC50 103.0 nM
Cc1c([C@@H](O)CN2CC3CCN(C(=O)c4ccc(-n5cnnn5)nc4)CC3C2)ccc2c1COC2=O CHEMBL3974535 IC50 103.0 nM
O=C(Cc1ccc(-n2cnnn2)nc1)N1CCN2C[C@H](c3ccc4nonc4c3)OC[C@@H]2C1 CHEMBL3933230 IC50 104.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CN(c2ccc(C#N)cn2)C3)ccc2c1COC2=O CHEMBL4087753 IC50 104.0 nM
Cc1ccc(C(=O)NCc2cn(C)nn2)cc1S(=O)(=O)Nc1ccc(-c2ccno2)cc1 CHEMBL4161489 IC50 104.0 nM
Cc1c([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@@H]3CO2)ccc2c1COC2=O CHEMBL3928846 IC50 105.0 nM
Cc1c([C@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)cn4)C[C@H]3CO2)ccc(F)c1C#N CHEMBL3928945 IC50 107.0 nM
Cc1c([C@@H](O)CN2CCC3(CCCN(C(=O)c4ccc(-n5cnnn5)nc4)C3)C2)ccc2c1COC2=O CHEMBL3941677 IC50 108.0 nM
O=C(Cc1ccc(-n2cnnn2)cc1)N1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1 CHEMBL2441433 IC50 110.0 nM
COc1cc(CCN2CCN(CC(OC)c3ccc4c(c3C)COC4=O)CC2)ccc1C#N CHEMBL3612800 IC50 110.0 nM
CO[C@@H](CN1CCC2(CC1)CC(=O)N(C1=C(C)C(=O)OC1)C2)c1ccc2c(c1C)COC2=O CHEMBL3960223 IC50 110.0 nM
Cc1c([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)cn4)C[C@H]3CO2)ccc2c1COC2=O CHEMBL3923574 IC50 110.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)cn4)C[C@H]3CO2)c1Cl CHEMBL3890107 IC50 110.0 nM
[C-]#[N+]c1scc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)c1C CHEMBL3955762 IC50 110.0 nM
[C-]#[N+]c1c(F)cc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)cc1OC CHEMBL3905862 IC50 110.0 nM
Cc1c(C#N)cccc1[C@H]1CN2CCN(C(=O)Cc3ccc(-n4cnnn4)nc3)C[C@H]2CO1 CHEMBL3896006 IC50 112.0 nM
Cc1c([C@@H](O)CN2C[C@H]3C[C@@H]2CN3C[C@@H](O)c2ccc3c(c2)C[C@H](C)OC3=O)ccc2c1COC2=O CHEMBL3937548 IC50 116.0 nM
Cc1c([C@@H](O)CN2CCCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)C3)C2)ccc2c1COC2=O CHEMBL3928662 IC50 117.0 nM
COc1cc(CCN2CCN(CC(O)c3ccc4c(c3C)COC4=O)CC2)ccc1C#N CHEMBL3612799 IC50 120.0 nM
O=C1OCc2cc(CCC3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)CC3)ccc21 CHEMBL3792423 IC50 120.0 nM
Cc1c([C@@H](O)CN2C[C@H]3C[C@@H]2CN3C[C@H](O)c2ccc3c(c2)C[C@@H](C)OC3=O)ccc2c1COC2=O CHEMBL4112317 IC50 120.0 nM
Cc1c([C@@H](O)CN2C[C@H]3C[C@@H]2CN3C[C@@H](O)c2ccc3c(c2)C[C@@H](C)OC3=O)ccc2c1COC2=O CHEMBL4109200 IC50 120.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)c1F CHEMBL3907453 IC50 120.0 nM
O=C1OCCc2cc([C@H]3CN4CCN(C(=O)Cc5ccc(-n6cnnn6)nc5)C[C@@H]4CO3)ccc21 CHEMBL3942711 IC50 120.0 nM
[C-]#[N+]c1ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)cc1OC CHEMBL3914104 IC50 120.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)cc4C)C[C@@H]3CO2)c1C CHEMBL4109881 IC50 120.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4C)C[C@H]3CO2)c1C CHEMBL3964510 IC50 120.0 nM
[C-]#[N+]c1c(F)cc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)cc1OC CHEMBL3933879 IC50 120.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4C)C[C@H]3CO2)c1C CHEMBL3917792 IC50 120.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@H]3CO2)c1OC CHEMBL3981098 IC50 120.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@H]3CN2)c1C CHEMBL4109815 IC50 120.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)cn4)C[C@H]3CN2)c1C CHEMBL4111740 IC50 120.0 nM
[C-]#[N+]c1cc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)cn4)C[C@H]3CO2)ccc1F CHEMBL3890676 IC50 120.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccnnc2)C3=O)ccc2c1COC2=O CHEMBL4086697 IC50 120.0 nM
Cc1cc(S(=O)(=O)N2CCCC23CCN(C[C@@H](O)c2ccc4c(c2C)COC4=O)C3)ccc1-n1cnnn1 CHEMBL4109814 IC50 125.0 nM
CCS(=O)(=O)c1cnc(N2CC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)CC2=O)cn1 CHEMBL4074870 IC50 127.0 nM
COc1cc(C(O)CN2CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)CC2)nc(C)c1C#N CHEMBL3612925 IC50 130.0 nM
Cc1cc(C#N)cnc1C(O)CN1CCN(C[C@H](O)c2ccc3c(c2C)COC3=O)CC1 CHEMBL3612922 IC50 130.0 nM
Cc1c([C@@H](O)CN2C3CCC2C2CCC3N2C(=O)c2ccc(-n3cnnn3)nc2)ccc2c1COC2=O CHEMBL3911583 IC50 130.0 nM
Cc1c([C@H](O)CN2C[C@@H]3C[C@H]2CN3CC(O)c2ccc3c(c2)C[C@H](C)OC3=O)ccc2c1COC2=O CHEMBL3942929 IC50 130.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)cn4)C[C@H]3CO2)c1C CHEMBL3950382 IC50 130.0 nM
[C-]#[N+]c1cccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)c1C CHEMBL3889681 IC50 130.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)c(F)c4)C[C@H]3CO2)c1C CHEMBL3968801 IC50 130.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ncns2)C3=O)ccc2c1COC2=O CHEMBL4070003 IC50 130.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccc(=O)n(C(F)F)n2)C3=O)ccc2c1COC2=O CHEMBL4070542 IC50 130.0 nM
Cc1c([C@@H](O)CN2CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)C3(CCCC3)C2)ccc2c1COC2=O CHEMBL3931450 IC50 134.0 nM
CC1CN(CCc2ccc([N+](=O)[O-])cc2)CCN1CCc1ccc([N+](=O)[O-])cc1 CHEMBL2146867 IC50 140.0 nM
Cc1c([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@@H]3CN2)ccc2c1COC2=O CHEMBL3898579 IC50 140.0 nM
Cc1c([C@@H](O)CN2[C@@H]3CC[C@H]2CN(C(=O)c2ccc(-n4cnnn4)nc2)C3)ccc2c1COC2=O CHEMBL3952746 IC50 140.0 nM
Cc1c([C@@H](O)CN2C[C@@H]3C[C@H]2CN3CC(O)c2ccc3c(c2)C[C@H](C)OC3=O)ccc2c1COC2=O CHEMBL3954970 IC50 140.0 nM
Cc1c([C@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@H]3CO2)ccc2c1COC2=O CHEMBL3954385 IC50 140.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)cc4C)C[C@@H]3CO2)c1C CHEMBL4111908 IC50 140.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)c1OC CHEMBL3947333 IC50 140.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4C)C[C@@H]3CO2)c1C CHEMBL4113152 IC50 140.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4C)C[C@H]3CO2)c1Cl CHEMBL3912385 IC50 140.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@@H]3CO2)c1Cl CHEMBL4109730 IC50 140.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)c(C)n4)C[C@@H]3CO2)c1C CHEMBL4107662 IC50 140.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)c(C)c4)C[C@@H]3CO2)c1C CHEMBL4109018 IC50 140.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4C)C[C@@H]3CO2)c1Cl CHEMBL4111488 IC50 140.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)c(F)c4)C[C@@H]3CO2)c1C CHEMBL4115298 IC50 140.0 nM
Cc1c([C@@H]2CN3CCN(C(=O)Nc4ccc(-n5cnnn5)nc4)C[C@@H]3CO2)ccc(F)c1C#N CHEMBL4106608 IC50 140.0 nM
Cc1c([C@H](O)CN2CCN(CCc3ccc4c(c3)C[C@@H](C)OC4=O)CC2)ccc2c1COC2=O CHEMBL4114415 IC50 145.0 nM
COc1cc(C(C)CN2CCN(CCc3ccc4c(c3C)COC4=O)CC2)ccc1C#N CHEMBL3612803 IC50 150.0 nM
[C-]#[N+]c1ccc(S(=O)(=O)NCC2CN(C[C@H](O)c3ccc4c(c3C)COC4=O)C2)cc1 CHEMBL3701209 IC50 150.0 nM
Cc1cc(S(=O)(=O)N2[C@@H]3CC[C@H]2CN(C[C@H](O)c2ccc4c(c2C)COC4=O)C3)ccc1-n1cnnn1 CHEMBL3951125 IC50 150.0 nM
Cc1c([C@@H](O)CN2C[C@@H]3C[C@H]2CN3C[C@H](O)c2ccc3c(c2)C[C@@H](C)OC3=O)ccc2c1COC2=O CHEMBL4108477 IC50 150.0 nM
CC1=C(N2CCC3(CCN(CC(NC4CC4)c4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O CHEMBL3951964 IC50 150.0 nM
O=C1OCc2c1ccc([C@H]1CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO1)c2Br CHEMBL3904560 IC50 150.0 nM
[C-]#[N+]c1c(Cl)ccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)c1C CHEMBL3942421 IC50 150.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)cn4)C[C@H]3CO2)c1C CHEMBL3915661 IC50 150.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@@H]3CO2)c1C CHEMBL4109362 IC50 150.0 nM
COc1cc(C(O)CN2CCN(CC(O)c3ccc4c(c3)C[C@H](C)OC4=O)CC2)ncc1C#N CHEMBL3928525 IC50 151.0 nM
O=C(Cc1ccc(-n2cnnn2)cc1)N1CCN(CCc2ccc3nonc3c2)CC1 CHEMBL2441436 IC50 160.0 nM
Cc1c(C#N)cccc1C1CN2CCN(C(=O)Cc3cnc(-n4cnnn4)nc3)CC2CO1 CHEMBL3937660 IC50 160.0 nM
C[C@@H]1Cc2cc(C3CN4CCN(C(=O)Cc5cnc(-n6cnnn6)nc5)CC4CO3)ccc2C(=O)O1 CHEMBL4112668 IC50 160.0 nM
Cc1nc(-n2cnnn2)ccc1CC(=O)N1CCN2C[C@H](c3ccc4c(c3)CCOC4=O)OCC2C1 CHEMBL4115429 IC50 160.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)cn4)C[C@@H]3CO2)c1C CHEMBL4113198 IC50 160.0 nM
[C-]#[N+]c1cc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)c(F)cc1F CHEMBL3951582 IC50 160.0 nM
Cc1c([C@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)cn4)C[C@H]3CO2)ccc2c1COC2=O CHEMBL3942839 IC50 160.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@H]3CO2)c1OC CHEMBL3955700 IC50 160.0 nM
Cc1c([C@@H]2CN3CCN(C(=O)Nc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)ccc(F)c1C#N CHEMBL3965496 IC50 160.0 nM
Cc1c(C(C)CN2CCN(C(=O)Cc3ccc(-n4cnnn4)cc3)CC2)ccc2c1COC2=O CHEMBL4522413 IC50 160.0 nM
O=[N+]([O-])c1ccc(CCN2CCN(CCc3ccc4nonc4c3)CC2)cc1 CHEMBL2146853 IC50 170.0 nM
COc1cc(CCN2CCN(CC(C)c3ccc4c(c3C)COC4=O)CC2)ccc1C#N CHEMBL3612797 IC50 170.0 nM
Cc1c([C@@H](O)CN2CC3CCC2CN3S(=O)(=O)c2ccc(-n3cnnn3)cc2)ccc2c1COC2=O CHEMBL3945854 IC50 170.0 nM
C[C@H]1Cc2cc(C3CN4CCN(C(=O)Cc5cnc(-n6cnnn6)nc5)CC4CO3)ccc2C(=O)O1 CHEMBL3917506 IC50 170.0 nM
Cc1cc(-n2cnnn2)ncc1CC(=O)N1CCN2C[C@@H](c3ccc4c(c3)CCOC4=O)OC[C@@H]2C1 CHEMBL3907469 IC50 170.0 nM
[C-]#[N+]c1c(F)cc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@@H]3CO2)cc1F CHEMBL4115533 IC50 170.0 nM
[C-]#[N+]c1c(F)cc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@@H]3CO2)cc1OC CHEMBL4113205 IC50 170.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4ncc(-n5cnnn5)cc4Cl)C[C@H]3CO2)c1C CHEMBL3933678 IC50 170.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5nnnc5C)cn4)C[C@H]3CO2)c1C CHEMBL3984656 IC50 170.0 nM
O=C1OCc2cc([C@H]3CN4CCN(C(=O)Cc5ccc(-n6cnnn6)cn5)C[C@H]4CO3)ccc21 CHEMBL3984382 IC50 180.0 nM
C[C@H]1Cc2cc([C@H]3CN4CCN(C(=O)Cc5ccc(-n6cnnn6)nc5)C[C@@H]4CO3)ccc2C(=O)O1 CHEMBL3899647 IC50 180.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)cn4)C[C@H]3CO2)c1OC CHEMBL3970670 IC50 180.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4cncc(-n5cnnn5)c4)C[C@H]3CO2)c1C CHEMBL3974310 IC50 180.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)c(C)n4)C[C@H]3CO2)c1C CHEMBL3890255 IC50 180.0 nM
[C-]#[N+]c1c(F)ccc(C2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)CC3CCO2)c1C CHEMBL3943796 IC50 180.0 nM
Cc1c([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CS2)ccc(F)c1C#N CHEMBL3965111 IC50 180.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2cnn(C)c(=O)c2)C3=O)ccc2c1COC2=O CHEMBL4075427 IC50 180.0 nM
COc1cc(CC(C)N2CCN(CCc3ccc4c(c3C)COC4=O)CC2)ccc1C#N CHEMBL3612802 IC50 190.0 nM
CC1=C(N2CCC3(CCN(C[C@@H](O)c4ccc5c(c4C)COC5=O)CC3F)C2=O)COC1=O CHEMBL4108430 IC50 190.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4ccnc(-n5cnnn5)c4)C[C@H]3CO2)c1C CHEMBL3897878 IC50 190.0 nM
[C-]#[N+]c1c(F)cc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)cc1F CHEMBL3919527 IC50 190.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4cc(C)c(-n5cnnn5)cn4)C[C@H]3CO2)c1C CHEMBL3894061 IC50 190.0 nM
[C-]#[N+]c1ccc([C@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@H]3CO2)cc1OC CHEMBL3972099 IC50 190.0 nM
[C-]#[N+]c1cc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)c(F)cc1OC CHEMBL3910599 IC50 190.0 nM
Cc1nccc(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)n1 CHEMBL4071603 IC50 190.0 nM
Cc1c([C@@H](O)CN2C3CCC2C2CCC3N2CC(O)c2ccc(C#N)cn2)ccc2c1COC2=O CHEMBL3976654 IC50 197.0 nM
Cc1c([C@@H](O)CN2C[C@@H]3C[C@H]2CN3S(=O)(=O)c2ccc(C#N)cc2)ccc2c1COC2=O CHEMBL3925446 IC50 200.0 nM
[C-]#[N+]c1cccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4C)C[C@H]3CO2)c1C CHEMBL3913289 IC50 200.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4C)C[C@@H]3CO2)c1C CHEMBL4109977 IC50 200.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)c(C)n4)C[C@@H]3CO2)c1C CHEMBL4107007 IC50 200.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4c(C)nc(-n5cnnn5)nc4C)C[C@@H]3CO2)c1C CHEMBL4110265 IC50 200.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4ncc(-n5cnnn5)cc4Cl)C[C@@H]3CO2)c1C CHEMBL4106818 IC50 200.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4C(F)(F)F)C[C@H]3CO2)c1C CHEMBL3971605 IC50 200.0 nM
Cc1c([C@@H](O)CN2CCCC3(CCCN(C[C@H](O)c4ccc5c(c4C)COC5=O)C3)C2)ccc2c1COC2=O CHEMBL3957558 IC50 201.0 nM
O=C1OCCc2cc([C@H]3CN4CCN(C(=O)Cc5ccc(-n6cnnn6)nc5)C[C@H]4CO3)ccc21 CHEMBL3940901 IC50 205.0 nM
CC1=C(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3F)C2=O)COC1=O CHEMBL3966889 IC50 210.0 nM
[C-]#[N+]CCNC(CN1CCC2(CC1)CCN(C1=C(C)C(=O)OC1)C2=O)c1ccc2c(c1C)COC2=O CHEMBL3925237 IC50 210.0 nM
Cc1cc(-n2cnnn2)ncc1CC(=O)N1CCN2C[C@H](c3ccc4c(c3C)COC4=O)OC[C@@H]2C1 CHEMBL3905104 IC50 210.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4C)C[C@@H]3CO2)c1C CHEMBL4112890 IC50 210.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nn4)C[C@@H]3CO2)c1C CHEMBL4113213 IC50 210.0 nM
Cc1c(C2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)CC3CCO2)ccc2c1COC2=O CHEMBL3970522 IC50 210.0 nM
Cc1c(C2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)CC3CCO2)ccc2c1COC2=O CHEMBL3957768 IC50 210.0 nM
CCOC(CN1CCN(CCc2ccc(C#N)c(OC)c2)CC1)c1ccc2c(c1C)COC2=O CHEMBL3612801 IC50 220.0 nM
COCCNC(CN1CCC2(CC1)CCN(C1=C(C)C(=O)OC1)C2=O)c1ccc2c(c1C)COC2=O CHEMBL3909772 IC50 220.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@@H]3CO2)c1F CHEMBL4113857 IC50 220.0 nM
[C-]#[N+]c1c(F)cc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@@H]3CO2)cc1OC CHEMBL4111127 IC50 220.0 nM
[C-]#[N+]c1cccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@@H]3CO2)c1C CHEMBL4114973 IC50 220.0 nM
[C-]#[N+]c1c(F)ccc(C2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)CC3CCO2)c1C CHEMBL3921308 IC50 220.0 nM
Cc1cc(-n2cnnn2)ncc1NC(=O)N1CCN2C[C@@H](c3ccc(F)c(C#N)c3C)OC[C@@H]2C1 CHEMBL3909746 IC50 220.0 nM
CC1=C(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3O)C2=O)COC1=O CHEMBL3935104 IC50 230.0 nM
[C-]#[N+]c1ccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)cc1OC CHEMBL3889640 IC50 230.0 nM
Cc1cc2c(cc1[C@H]1CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO1)COC2=O CHEMBL3934674 IC50 230.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4ncc(-n5cnnn5)cc4C)C[C@H]3CO2)c1C CHEMBL3968943 IC50 230.0 nM
C[C@@H]1Cc2cc([C@@H]3CN4CCN(C(=O)Cc5ccc(-n6cnnn6)nc5)C[C@H]4CN3)ccc2C(=O)O1 CHEMBL4110392 IC50 230.0 nM
[C-]#[N+]c1ccc(S(=O)(=O)N2CCC3CN(C[C@H](O)c4ccc5c(c4)COC5=O)CC32)cc1 CHEMBL3914370 IC50 234.0 nM
CC(Cc1ccc([N+](=O)[O-])cc1)N1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1 CHEMBL2146866 IC50 240.0 nM
O=[N+]([O-])c1ccc2nc(COCc3nc4ccc([N+](=O)[O-])cc4[nH]3)[nH]c2c1 CHEMBL2146753 IC50 240.0 nM
C[C@H]1Cc2cc(CCN3CCN(CCc4ccc5c(c4)C[C@H](C)OC5=O)CC3)ccc2C(=O)O1 CHEMBL3663632 IC50 240.0 nM
Cc1c([C@@H](O)CN2CCC3(CCCN(C4=CC(=O)OC4)C3)CC2)ccc2c1COC2=O CHEMBL3970099 IC50 240.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4ncc(-n5cnnn5)cc4C)C[C@H]3CO2)c1C CHEMBL3899685 IC50 240.0 nM
O=C1OCCc2cc([C@@H]3CN4CCN(C(=O)Cc5cnc(-n6cnnn6)nc5)C[C@H]4CO3)ccc21 CHEMBL3894177 IC50 240.0 nM
[C-]#[N+]c1cc([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@H]3CN2)ccc1F CHEMBL4110963 IC50 240.0 nM
Cc1c([C@@H](O)CN2CCCC2CNS(=O)(=O)c2ccc(-n3cnnn3)cc2)ccc2c1COC2=O CHEMBL3701213 IC50 245.0 nM
O=C1OCc2c1ccc(CCN1CCN(C(=O)Cc3ccc(-n4cnnn4)cc3)CC1)c2Cl CHEMBL2441421 IC50 250.0 nM
CC1=C(N2CCC3(CCN(CC(NCC(F)F)c4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O CHEMBL3933519 IC50 250.0 nM
[C-]#[N+]c1ccc([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)cc4C)C[C@@H]3CO2)cc1OC CHEMBL4110624 IC50 250.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4cccc(-n5cnnn5)n4)C[C@H]3CO2)c1C CHEMBL3896814 IC50 250.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4cc(C)c(-n5cnnn5)cn4)C[C@@H]3CO2)c1C CHEMBL4113647 IC50 250.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)cn4)C[C@H]3CN2)c1C CHEMBL4115667 IC50 250.0 nM
Cc1c([C@@H]2CN3CCN(C(=O)Nc4ccc(-n5cnnn5)cn4)C[C@@H]3CO2)ccc(F)c1C#N CHEMBL4115675 IC50 250.0 nM
Cc1nsc(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2)n1 CHEMBL4071221 IC50 250.0 nM
Cc1c([C@@H](O)CN2CCCC2CNCC(O)c2ccc(C#N)cn2)ccc2c1COC2=O CHEMBL3701205 IC50 254.0 nM
[C-]#[N+]c1ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@@H]3CO2)cc1OC CHEMBL4108095 IC50 260.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4C(F)(F)F)C[C@H]3CO2)c1C CHEMBL3947314 IC50 260.0 nM
Cc1nc(-n2cnnn2)ccc1[C@@H](O)CN1CCC2(CC1)CCN(c1ccc(=O)n(C)n1)C2=O CHEMBL4071084 IC50 260.0 nM
Cc1c([C@@H](O)CN2CCCCC2CNCC(O)c2ccc(C#N)cn2)ccc2c1COC2=O CHEMBL3701208 IC50 269.0 nM
Cc1cc(S(=O)(=O)N2C[C@@H]3C[C@H]2CN3C[C@H](O)c2ccc3c(c2C)COC3=O)ccc1-n1cnnn1 CHEMBL3978494 IC50 270.0 nM
[C-]#[N+]c1scc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)cn4)C[C@H]3CO2)c1C CHEMBL3928137 IC50 270.0 nM
[C-]#[N+]c1c(F)cc([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@@H]3CO2)cc1F CHEMBL4113278 IC50 270.0 nM
Cc1c([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)cn4)C[C@H]3CS2)ccc(F)c1C#N CHEMBL3974187 IC50 270.0 nM
Cc1c([C@@H](O)CN2CCC3CN(C(=O)c4ccc(-n5cnnn5)nc4)CC32)ccc2c1COC2=O CHEMBL3979419 IC50 270.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2cn(C)c(=O)cn2)C3=O)ccc2c1COC2=O CHEMBL4084167 IC50 270.0 nM
O=[N+]([O-])c1ccc(CN2CCOCCOCCN(Cc3ccc([N+](=O)[O-])cc3)CCOCC2)cc1 CHEMBL1354806 IC50 272.6 nM
Cc1c(C(CO)NCC2CCCN2C[C@H](O)c2ccc3c(c2C)COC3=O)ccc2c1COC2=O CHEMBL3701203 IC50 278.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)c(C)c4)C[C@@H]3CO2)c1C CHEMBL4111303 IC50 280.0 nM
Cc1c([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CS2(=O)=O)ccc(F)c1C#N CHEMBL3897754 IC50 280.0 nM
Cc1cc(-n2cnnn2)ncc1NC(=O)N1CCN2C[C@H](c3ccc(F)c(C#N)c3C)OC[C@H]2C1 CHEMBL4110978 IC50 280.0 nM
O=[N+]([O-])c1ccc(CN2CCOCCOCCN(Cc3ccc([N+](=O)[O-])cc3)CCOCC2)cc1 CHEMBL1401670 IC50 290.0 nM
[C-]#[N+]c1c(OC)ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)c1C CHEMBL3927101 IC50 290.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)cn4)C[C@H]3CO2)c1F CHEMBL3967419 IC50 290.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4c(C)nc(-n5cnnn5)nc4C)C[C@H]3CO2)c1C CHEMBL3940361 IC50 290.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)C(C)c4cnc(-n5cnnn5)nc4)C[C@H]3CO2)c1C CHEMBL3950059 IC50 290.0 nM
N#Cc1ccc(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)cc1 CHEMBL2146871 IC50 300.0 nM
CCc1c(CCN2CCN(C(=O)Cc3ccc(-n4cnnn4)cc3)CC2)ccc2c1COC2=O CHEMBL2441418 IC50 300.0 nM
COc1cc(C(C)(C)CN2CCN(CCc3ccc4c(c3C)COC4=O)CC2)ccc1C#N CHEMBL3612804 IC50 300.0 nM
[C-]#[N+]c1cc([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@@H]3CO2)ccc1F CHEMBL4110319 IC50 300.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4c(C)nc(-n5cnnn5)nc4C)C[C@@H]3CO2)c1C CHEMBL4112834 IC50 300.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nn4)C[C@H]3CO2)c1C CHEMBL3928736 IC50 300.0 nM
[C-]#[N+]c1c(C)c([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@@H]3CO2)cc(C)c1F CHEMBL4108941 IC50 300.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CC(=O)N(c2ccc(S(C)(=O)=O)nc2)C3)ccc2c1COC2=O CHEMBL4105076 IC50 308.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)C(C)c4ccc(-n5cnnn5)nc4C)C[C@H]3CO2)c1C CHEMBL3956833 IC50 310.0 nM
[C-]#[N+]c1ccc(N2C[C@H]3CC[C@@H](C2)N3C[C@H](O)c2ccc3c(c2C)COC3=O)nc1 CHEMBL3967209 IC50 316.0 nM
Cc1c([C@@H](O)CN2CCCC3(CCCN(C(=O)c4ccc(S(C)(=O)=O)nc4)C3)C2)ccc2c1COC2=O CHEMBL3900206 IC50 319.4 nM
CC1=C(N2CCC3(CCN(CC(c4ccc5c(c4C)COC5=O)N4CCC4)CC3)C2=O)COC1=O CHEMBL3937712 IC50 320.0 nM
[C-]#[N+]c1cccc([C@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@H]3CO2)c1C CHEMBL3916415 IC50 320.0 nM
[C-]#[N+]c1ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4C)C[C@H]3CO2)cc1OC CHEMBL3982314 IC50 320.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)cc4CC)C[C@@H]3CO2)c1C CHEMBL4112679 IC50 320.0 nM
C[C@@H]1Cc2cc(C3CN4CCN(C(=O)Cc5ccc(-n6cnnn6)nc5)CC4(C)CO3)ccc2C(=O)O1 CHEMBL4111364 IC50 320.0 nM
Cc1c([C@@H]2CN3CCN(C(=O)Nc4ccc(-n5cnnn5)cn4)C[C@H]3CO2)ccc(F)c1C#N CHEMBL3936577 IC50 320.0 nM
O=C1OCc2cc(CCN3CCN(C(=O)Cc4ccc(-n5cnnn5)cc4C4CC4)CC3)ccc21 CHEMBL2441415 IC50 330.0 nM
[C-]#[N+]c1cccc([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@@H]3CO2)c1C CHEMBL4112459 IC50 330.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4C)C[C@@H]3CO2)c1C CHEMBL4107321 IC50 330.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4ncc(-n5cnnn5)cc4OC)C[C@@H]3CO2)c1C CHEMBL4107451 IC50 330.0 nM
[C-]#[N+]c1c(OC)ccc([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@H]3CO2)c1C CHEMBL3906498 IC50 330.0 nM
CC(CN1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1)c1ccc([N+](=O)[O-])cc1 CHEMBL2146865 IC50 340.0 nM
Cc1c([C@@H](O)CN2CCN(CC(O)c3ncc(C#N)cc3Cl)CC2)ccc2c1COC2=O CHEMBL3612923 IC50 340.0 nM
[C-]#[N+]c1ccc(NCC2(c3ccccc3)CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)C2)nc1 CHEMBL3701216 IC50 340.0 nM
CC1=C(N2C(=O)C3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)CC2C2CC2)COC1=O CHEMBL3893441 IC50 340.0 nM
[C-]#[N+]c1cc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)cn4)C[C@H]3CO2)c(F)cc1F CHEMBL3980493 IC50 340.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4ccnc(-n5cnnn5)c4)C[C@H]3CO2)c1C CHEMBL3969072 IC50 340.0 nM
O=C(Cc1ccc(-n2cnnn2)nc1)N1CCN2C[C@@H](c3cccc(-n4cnnn4)c3)OC[C@@H]2C1 CHEMBL3917904 IC50 340.0 nM
Cc1cc(-n2cnnn2)ncc1NC(=O)N1CCN2C[C@@H](c3ccc(F)c(C#N)c3C)OC[C@H]2C1 CHEMBL4114984 IC50 340.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2cc(-c4ccccc4)ns2)C3=O)ccc2c1COC2=O CHEMBL4093627 IC50 340.0 nM
Cc1c([C@@H](O)CN2CCCC3(CCCN3C[C@H](O)c3ccc4c(c3C)COC4=O)C2)ccc2c1COC2=O CHEMBL3921091 IC50 348.0 nM
C[C@@H]1Cc2cc([C@]3(C)CN4CCN(C(=O)Cc5ccc(-n6cnnn6)nc5)C[C@H]4CO3)ccc2C(=O)O1 CHEMBL4112811 IC50 350.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4cccc(-n5cnnn5)n4)C[C@@H]3CO2)c1C CHEMBL4109354 IC50 350.0 nM
[C-]#[N+]c1cc([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@H]3CO2)c(F)cc1OC CHEMBL3942717 IC50 350.0 nM
[C-]#[N+]c1c(C)c([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@@H]3CO2)cc(C)c1F CHEMBL4110210 IC50 350.0 nM
O=C(Cc1ccc(-n2cnnn2)cn1)N1CCN2C[C@@H](c3ccc4nonc4c3)OC[C@@H]2C1 CHEMBL3950743 IC50 350.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)C(F)(F)c4cnc(-n5cnnn5)nc4)C[C@H]3CO2)c1C CHEMBL3968924 IC50 350.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)OCCN(c2ccc(=O)n(C)n2)C3=O)ccc2c1COC2=O CHEMBL4075425 IC50 350.0 nM
Cc1c([C@H](O)CN2CCC3(CC2)CCN(C2=CC(=O)OC2)C3=O)ccc2c1COC2=O CHEMBL4111474 IC50 370.0 nM
CC1=C(N2CCC3(CCN(CC(NC4CCC4)c4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O CHEMBL3953064 IC50 370.0 nM
[C-]#[N+]c1ccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)cc1F CHEMBL3914420 IC50 370.0 nM
[C-]#[N+]c1c(F)cc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)cc1F CHEMBL3891458 IC50 370.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)c1C1CC1 CHEMBL3908625 IC50 380.0 nM
[C-]#[N+]c1scc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)cn4)C[C@H]3CO2)c1C CHEMBL3937000 IC50 390.0 nM
[C-]#[N+]c1cncc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)c1C CHEMBL3906696 IC50 390.0 nM
Cc1c([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@@H]3CO2)ccc2c1COC2=O CHEMBL4115217 IC50 390.0 nM
[C-]#[N+]c1ccc([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@H]3CO2)cc1OC CHEMBL3904462 IC50 390.0 nM
[C-]#[N+]c1c(F)ccc([C@H]2CN3CCN(C(=O)Cc4cccc(-n5cnnn5)n4)C[C@@H]3CO2)c1C CHEMBL4115283 IC50 390.0 nM
Cc1c([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CN2)ccc2c1COC2=O CHEMBL4114405 IC50 390.0 nM
Cc1ccc(NS(=O)(=O)c2cc(C(=O)NCc3nc(C)no3)ccc2C)cc1 CHEMBL4162926 pIC50 398.11 nM
Cc1c([C@@H](O)CN2CCN(C[C@@H](O)c3ccc(C#N)cn3)CC2)ccc2c1COC2=O CHEMBL3612808 IC50 410.0 nM
CNc1cc(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)ccc1C#N CHEMBL2146881 IC50 410.0 nM
Cc1c([C@@H](O)CNC2(C3CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)C3)CCC2)ccc2c1COC2=O CHEMBL3701201 IC50 420.0 nM
C[C@H]1Cc2cc([C@]3(C)CN4CCN(C(=O)Cc5ccc(-n6cnnn6)nc5)C[C@H]4CO3)ccc2C(=O)O1 CHEMBL3934359 IC50 420.0 nM
Cc1c([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CS2)ccc2c1COC2=O CHEMBL3968794 IC50 420.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccc(=O)n(C)c2)C3=O)ccc2c1COC2=O CHEMBL4078280 IC50 420.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CN(c2ccns2)C3)ccc2c1COC2=O CHEMBL4081764 IC50 420.0 nM
O=C1OCc2c1ccc(CCN1CCN(C(=O)Cc3ccc(-n4cnnn4)cc3)CC1)c2C1CC1 CHEMBL2441419 IC50 430.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccncn2)C3=O)ccc2c1COC2=O CHEMBL4072014 IC50 430.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2cc(C)c(=O)n(C)n2)C3=O)ccc2c1COC2=O CHEMBL4061173 IC50 430.0 nM
O=C1OCc2cc(CCN3CCN(C(=O)Cc4ccc(-n5cnnn5)cc4)CC3)cc(F)c21 CHEMBL2441427 IC50 440.0 nM
Cc1c(C(CO)NCC2CCCCN2C[C@H](O)c2ccc3c(c2C)COC3=O)ccc2c1COC2=O CHEMBL3701204 IC50 446.0 nM
COc1cc(CC(=O)N2CCN(CCc3ccc4c(c3)COC4=O)CC2)ccc1-n1cnnn1 CHEMBL2441410 IC50 450.0 nM
O=C1OCc2cc(CCN3CCN(C(=O)Cc4ccc(-n5cnnn5)cc4)CC3)c(F)cc21 CHEMBL2441424 IC50 460.0 nM
Cc1cc2c(cc1CCN1CCN(C(=O)Cc3ccc(-n4cnnn4)cc3)CC1)COC2=O CHEMBL2441423 IC50 460.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)cn4)C[C@H]3CO2)c1OC CHEMBL3984820 IC50 460.0 nM
Cc1c(C(O)CN2CCc3nc(-c4ccc(C#N)cc4F)ncc3C2)ccc2c1COC2=O CHEMBL3904835 IC50 463.0 nM
N#Cc1cccc(CCN2CCN(C(=O)Cc3ccc(-n4cnnn4)cc3)CC2)c1 CHEMBL2441435 IC50 470.0 nM
Cc1cc(C#N)ccc1-c1ncc2c(n1)CCN(CCc1ccc3c(c1C)COC3=O)C2 CHEMBL3930903 IC50 477.1 nM
Cc1c(C2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)CC3CO2)ccc2c1COC2=O CHEMBL3911512 IC50 480.0 nM
Cc1c([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)cccc1-n1cnnn1 CHEMBL3945797 IC50 480.0 nM
[C-]#[N+]c1c(F)cc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@@H]3CO2)cc1F CHEMBL4111683 IC50 490.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CN(c2ccc(=O)n(C)n2)C(=O)O3)ccc2c1COC2=O CHEMBL4093837 IC50 490.0 nM
O=C1OCCc2cc([C@@H]3CN4CCN(C(=O)Cc5cnc(-n6cnnn6)cn5)C[C@H]4CO3)ccc21 CHEMBL3960187 IC50 500.0 nM
Cc1c([C@@H](O)CNCC2CCCN2C[C@H](O)c2ccc3c(c2C)COC3=O)ccc2c1COC2=O CHEMBL3701202 IC50 510.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2cc(-c4ccccc4)no2)C3=O)ccc2c1COC2=O CHEMBL4072929 IC50 510.0 nM
Cc1c(C(O)CN2CCN(C(=O)Cc3ccc(-n4cnnn4)cc3)CC2)ccc2c1COC2=O CHEMBL4438583 IC50 510.0 nM
O=C1OCc2cc(CCN3CCN(C(=O)Cc4ccc(-n5cnnn5)cc4C(F)(F)F)CC3)ccc21 CHEMBL2441416 IC50 520.0 nM
O=C(Cc1cnc(-n2cnnn2)nc1)N1CCN2C[C@@H](c3ccc4nonc4c3)OC[C@@H]2C1 CHEMBL3935471 IC50 530.0 nM
O=C1OCc2cc(CC(=O)N3CCN(CCc4ccc([N+](=O)[O-])cc4)CC3)ccc21 CHEMBL2441431 IC50 540.0 nM
Cc1c([C@H](O)CN2CC3CN(CC(O)c4ccc(C#N)cn4)C3C2)ccc2c1COC2=O CHEMBL4112713 IC50 540.0 nM
CSc1cc(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)ccc1C#N CHEMBL2146880 IC50 550.0 nM
N#Cc1cc(CC(=O)N2CCN(CCc3ccc4c(c3)COC4=O)CC2)ccc1-n1cnnn1 CHEMBL2441411 IC50 550.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CC(=O)N(c2ccns2)C3)ccc2c1COC2=O CHEMBL4067063 IC50 550.0 nM
[C-]#[N+]c1c(F)ccc([C@@H]2CN3CCN(C(=O)Cc4cccc(-n5cnnn5)n4)C[C@H]3CO2)c1C CHEMBL3921335 IC50 560.0 nM
Cc1c([C@H](O)CN2CCN(CCc3ccc4c(c3)CCOC4=O)CC2)ccc2c1COC2=O CHEMBL4108603 IC50 564.0 nM
Cc1c([C@H](O)CN2CCC3CN(CC(O)c4ccc(C#N)cn4)CC32)ccc2c1COC2=O CHEMBL4112388 IC50 566.0 nM
Cn1nc(N2CCC3(CCN(C[C@H](O)c4ccc(-n5cnnn5)nn4)CC3)C2=O)ccc1=O CHEMBL4098143 IC50 570.0 nM
C[C@H]1Cc2cc([C@H]3CN4CCN(C(=O)Cc5ccc(-n6cnnn6)nc5)C[C@H]4CO3)ccc2C(=O)O1 CHEMBL3967395 IC50 580.0 nM
Cc1c([C@H](O)CN2CC[C@@H](NC[C@H](O)c3ccc4c(c3C)COC4=O)C2)ccc2c1COC2=O CHEMBL3701200 IC50 595.0 nM
Cc1c([C@@H](O)CN2CCC3CN(C(=O)c4ccc(-n5cnnn5)cn4)CC32)ccc2c1COC2=O CHEMBL3950394 IC50 602.2 nM
O=C1OCc2cc(CCN3CCN(C(=O)Cc4ccc(-n5cnnn5)c(F)c4)CC3)ccc21 CHEMBL2441409 IC50 610.0 nM
N#Cc1ccc(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)cc1OC(F)(F)F CHEMBL2146878 IC50 620.0 nM
Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccc(=O)n(C)n2)CC3)ccc2c1COC2=O CHEMBL4076697 IC50 620.0 nM
Cc1c([C@H](O)CN2CCC3CN(S(=O)(=O)c4ccc(C#N)cc4)CC32)ccc2c1COC2=O CHEMBL4110272 IC50 662.0 nM
O=C1OCc2c1ccc([C@@H]1CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO1)c2Cl CHEMBL3945109 IC50 670.0 nM
[C-]#[N+]c1c(Cl)ccc([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)c1C CHEMBL3899496 IC50 680.0 nM
Cc1c([C@@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)cn4)C[C@@H]3CO2)ccc2c1COC2=O CHEMBL4111351 IC50 690.0 nM
Cc1cc2c(cc1[C@@H]1CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO1)COC2=O CHEMBL3933589 IC50 750.0 nM
COc1cc(C(O)CN2CC3CN(C[C@H](O)c4ccc5c(c4C)COC5=O)C3C2)ncc1C#N CHEMBL3931092 IC50 788.5 nM
N#Cc1ccc(CCN2CCN(CCc3ccc(C#N)cc3)CC2)cc1 CHEMBL2146868 IC50 790.0 nM
O=C1OCc2cc(CCN3CCN(C(=O)Cc4ccc(-n5cnnn5)cc4)CC3)cc(Cl)c21 CHEMBL2441428 IC50 830.0 nM
Cc1c([C@@H](O)CN2CCN(CC(O)c3cc(C(F)(F)F)c(C#N)cn3)CC2)ccc2c1COC2=O CHEMBL3612927 IC50 850.0 nM
Cc1c([C@@H](O)CN2CC3CCN(C(=O)c4ccc(C#N)cn4)CC3C2)ccc2c1COC2=O CHEMBL3889848 IC50 865.0 nM
CSc1ccc(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2)cn1 CHEMBL4068517 IC50 901.0 nM
Cc1c([C@@H](O)CN2CC3CN(CC(O)c4ccc(C#N)cn4)C3C2)ccc2c1COC2=O CHEMBL3901043 IC50 916.3 nM
N#Cc1ccc(CCN2CCN(C(=O)Cc3ccc(-n4cnnn4)cc3)CC2)cc1 CHEMBL2441434 IC50 920.0 nM
COc1ccc(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2)cn1 CHEMBL4089640 IC50 1000.0 nM