CCc1c(C)[nH]c2c(-c3cnn(-c4cc(CO)ccn4)c3)cnn2c1=O CHEMBL3786038 IC50 2.3 nM
CN(C)CCc1cnn(-c2cc(C(=O)O)ccn2)c1OCc1ccc(F)cc1 CHEMBL4228806 IC50 3.0 nM
N#Cc1ccc(COc2ccnn2-c2cc(C(=O)O)ccn2)cc1 CHEMBL4229271 IC50 4.0 nM
CCCCCCN(C)CCc1ccc(-c2[nH]c3c(C#N)cnn3c(=O)c2C(C)C)cc1 CHEMBL4542928 IC50 4.37 nM
CCCCCCCN(C)Cc1ccc(-c2[nH]c3c(C#N)cnn3c(=O)c2C(C)C)cc1 CHEMBL5272926 IC50 4.37 nM
CC(C)c1c(-c2cn[nH]c2)[nH]c2c(C#N)cnn2c1=O CHEMBL4594120 IC50 5.3 nM
CC(C)c1c(-c2cnn(-c3ccccc3)c2)[nH]c2c(C#N)cnn2c1=O CHEMBL4548921 IC50 5.6 nM
O=C(O)c1ccnc(-n2nccc2OCc2ccc(Br)cc2)c1 CHEMBL4226978 IC50 6.0 nM
CC(C)c1c(-c2ccco2)[nH]c2c(C#N)cnn2c1=O CHEMBL4518175 IC50 6.2 nM
CC(C)c1c(-c2cnn(C3CC3)c2)[nH]c2c(C#N)cnn2c1=O CHEMBL4469253 IC50 7.9 nM
N#Cc1cnn2c(=O)c(C3CCC3)c(-c3ccccc3)[nH]c12 CHEMBL4435805 IC50 9.2 nM
Cc1[nH]c2c(C#N)cnn2c(=O)c1C(C)C CHEMBL4468119 IC50 9.3 nM
CCc1[nH]c2c(C#N)cnn2c(=O)c1C(C)C CHEMBL4525674 IC50 9.5 nM
CC(C)c1c(-c2cncnc2)[nH]c2c(C#N)cnn2c1=O CHEMBL4468139 IC50 10.0 nM
CC(C)c1c(-c2ccccc2)[nH]c2c(C#N)cnn2c1=O CHEMBL4454253 IC50 10.0 nM
CC(C)c1c(-c2cnn(CCNC(=O)CCl)c2)[nH]c2c(C#N)cnn2c1=O CHEMBL5277258 IC50 10.0 nM
CC(C)c1c(-c2cnn(CCC#N)c2)[nH]c2c(C#N)cnn2c1=O CHEMBL4444473 IC50 10.1 nM
COCCn1cc(-c2[nH]c3c(C#N)cnn3c(=O)c2C(C)C)cn1 CHEMBL4464271 IC50 10.4 nM
CCc1c(-c2ccc(=O)[nH]c2)[nH]c2c(C#N)cnn2c1=O CHEMBL4538785 IC50 11.0 nM
CCn1cc(-c2[nH]c3c(C#N)cnn3c(=O)c2C(C)C)cn1 CHEMBL4587659 IC50 11.1 nM
CC(C)c1c(-c2cnn(C3CCC3)c2)[nH]c2c(C#N)cnn2c1=O CHEMBL4542354 IC50 11.2 nM
CC(C)c1c(Cc2ccccc2)[nH]c2c(C#N)cnn2c1=O CHEMBL4567032 IC50 11.9 nM
COc1cc(Cl)ccc1COc1ccnn1-c1cc(C(=O)O)ccn1 CHEMBL4228292 IC50 12.0 nM
CC(C)c1c(-c2cccnc2)[nH]c2c(C#N)cnn2c1=O CHEMBL4537301 IC50 12.3 nM
C#CC(C)c1c(-c2ccccc2)[nH]c2c(C#N)cnn2c1=O CHEMBL4516977 IC50 12.8 nM
Cc1cc(Cl)ccc1COc1ccnn1-c1cc(C(=O)O)ccn1 CHEMBL3786952 IC50 13.0 nM
CCc1c(-c2cccnc2)[nH]c2c(C#N)cnn2c1=O CHEMBL4444632 IC50 13.0 nM
CC(C)c1c(CCc2ccccc2)[nH]c2c(C#N)cnn2c1=O CHEMBL4444121 IC50 13.1 nM
CC(C)c1c(-c2cnn(C)c2)[nH]c2c(C#N)cnn2c1=O CHEMBL4539736 IC50 13.3 nM
CC(C)c1c(-c2cnn(C(C)C)c2)[nH]c2c(C#N)cnn2c1=O CHEMBL4458334 IC50 13.8 nM
CC(C)c1c(-c2cccc(C(F)(F)F)c2)[nH]c2c(C#N)cnn2c1=O CHEMBL4447703 IC50 13.9 nM
CC(C)c1c(-c2cnn(C(C)(C)C)c2)[nH]c2c(C#N)cnn2c1=O CHEMBL3785583 IC50 14.0 nM
O=C(O)c1ccnc(-n2nccc2OCc2ccc(Cl)cc2)c1 CHEMBL3785832 IC50 14.0 nM
CC(C)Cn1cc(-c2[nH]c3c(C#N)cnn3c(=O)c2C(C)C)cn1 CHEMBL3785443 IC50 15.0 nM
CCc1c(-c2ccccc2)[nH]c2c(C#N)cnn2c1=O CHEMBL4464860 IC50 15.0 nM
CCOC(=O)c1c(O)c2ccncc2[nH]c1=O CHEMBL4637168 IC50 15.1 nM
C=CC(C)c1c(-c2ccccc2)[nH]c2c(C#N)cnn2c1=O CHEMBL4577929 IC50 15.5 nM
CC(C)c1c(-c2cnn(C3COC3)c2)[nH]c2c(C#N)cnn2c1=O CHEMBL4450386 IC50 15.9 nM
CC(C)c1c(/C=C/c2ccccc2)[nH]c2c(C#N)cnn2c1=O CHEMBL4457381 IC50 17.5 nM
O=C(O)c1ccnc(-n2nccc2OCc2ccc(Cl)cc2F)c1 CHEMBL4228546 IC50 18.0 nM
CC(C)c1c(Oc2ccccc2)[nH]c2c(C#N)cnn2c1=O CHEMBL4434847 IC50 18.0 nM
CCC(C)c1c(-c2ccccc2)[nH]c2c(C#N)cnn2c1=O CHEMBL4470689 IC50 18.0 nM
CC(C)c1c(-c2ccc(C(F)(F)F)cc2)[nH]c2c(C#N)cnn2c1=O CHEMBL4564949 IC50 18.2 nM
CCOc1cc(Cl)ccc1COc1ccnn1-c1cc(C(=O)O)ccn1 CHEMBL4229264 IC50 19.0 nM
CCc1c(C)[nH]c2c(C#N)cnn2c1=O CHEMBL4468103 IC50 20.0 nM
C=Cc1c(-c2ccccc2)[nH]c2c(C#N)cnn2c1=O CHEMBL4551293 IC50 20.1 nM
Cc1ccc(-c2[nH]c3c(C#N)cnn3c(=O)c2C(C)C)cc1 CHEMBL4546025 IC50 20.3 nM
CC(C)c1c(-c2ccc(Cl)cc2)[nH]c2c(C#N)cnn2c1=O CHEMBL4518024 IC50 20.4 nM
C#CCc1c(-c2ccccc2)[nH]c2c(C#N)cnn2c1=O CHEMBL4462289 IC50 21.1 nM
CCCCCCN(C)Cc1ccc(-c2[nH]c3c(C#N)cnn3c(=O)c2C(C)C)cc1 CHEMBL4536443 IC50 22.7 nM
Cc1cc(O[C@H](C)C(=O)NCC(=O)NCC(=O)O)c2c3c(c(=O)oc2c1)CCC3 CHEMBL5175566 IC50 23.8 nM
C/C=C/c1[nH]c2c(C#N)cnn2c(=O)c1C(C)C CHEMBL4457963 IC50 24.0 nM
C=C/C(O[C@H](C)C(=O)NCC(=O)NCC(=O)O)=c1/c2c(c(=O)oc1=C)CCC2 CHEMBL5273040 IC50 24.0 nM
C=C(C)c1c(-c2ccccc2)[nH]c2c(C#N)cnn2c1=O CHEMBL4540055 IC50 24.7 nM
COc1ccc(-n2cc(C(=O)NCC(C)(C)N3CCOCC3)c(-c3ccccc3)n2)cc1 CHEMBL4782583 IC50 24.9 nM
N#Cc1c(O)c2ccncc2[nH]c1=O CHEMBL4560583 IC50 25.0 nM
CCN(CCN(C)C)C(=O)CNCc1cc(C(=O)O)ccn1 CHEMBL3787669 IC50 25.0 nM
CC(C)(CNC(=O)c1cn(-c2ccccc2)nc1-c1ccccc1)N1CCOCC1 CHEMBL5287501 IC50 25.0 nM
CCN(CCN(C)C)C(=O)CNCc1cc(C(N)=O)ccn1 CHEMBL4078388 IC50 27.0 nM
CC(C)c1c(Nc2ccccc2)[nH]c2c(C#N)cnn2c1=O CHEMBL4544982 IC50 27.5 nM
CC(C)c1c[nH]c2c(C#N)cnn2c1=O CHEMBL4449759 IC50 28.3 nM
CC(C)c1c(-c2cccc(OC(F)(F)F)c2)[nH]c2c(C#N)cnn2c1=O CHEMBL4570968 IC50 28.9 nM
CCc1cnn(-c2cc(C(=O)O)ccn2)c1OCc1ccc(F)cc1 CHEMBL4225915 IC50 29.0 nM
CC(CO)c1c(-c2ccccc2)[nH]c2c(C#N)cnn2c1=O CHEMBL4474549 IC50 29.0 nM
N#Cc1cnn2c(=O)c(Br)c(-c3ccccc3)[nH]c12 CHEMBL4589575 IC50 29.3 nM
C=CC(=O)Nc1cccc(CN(C)CCc2cnn(-c3nccc4c(=O)[nH]cnc34)c2)c1 CHEMBL5277129 IC50 30.0 nM
COc1cc(-c2[nH]c3c(C#N)cnn3c(=O)c2C(C)C)ccn1 CHEMBL4548987 IC50 31.6 nM
Cc1ccc(COc2ccnn2-c2cc(C(=O)O)ccn2)cc1 CHEMBL4228087 IC50 32.0 nM
O=C(O)c1ccnc(-n2nccc2OCc2ccc(Cl)cc2OCc2ccccc2)c1 CHEMBL4227526 IC50 32.0 nM
CC(C)c1c(-c2ccc(OC(F)(F)F)cc2)[nH]c2c(C#N)cnn2c1=O CHEMBL4442998 IC50 35.9 nM
O=C(O)c1ccnc(-n2nccc2OCc2ccc(F)cc2)c1 CHEMBL4225013 IC50 38.0 nM
CCc1ccc(COc2ccnn2-c2cc(C(=O)O)ccn2)cc1 CHEMBL4227237 IC50 44.0 nM
CC(C)c1cc(C(=O)N2CC[C@@H](NC(=O)C3CC3)C2)[nH]n1 CHEMBL4088737 IC50 45.0 nM
CCNC(=O)c1c(O)c2ccncc2[nH]c1=O CHEMBL4441819 IC50 50.0 nM
CC(C)c1c(-c2ccc(OCCNC(=O)CCl)cc2)[nH]c2c(C#N)cnn2c1=O CHEMBL5285505 IC50 50.0 nM
CCCc1c(C)[nH]c2c(C#N)cnn2c1=O CHEMBL4557175 IC50 55.0 nM
O=C(O)c1ccnc2cc([C@@H](OCCN3CCCCC3)c3ccccc3Cl)[nH]c12 CHEMBL4096760 Kd 60.0 nM
CC(C)c1cc(C(=O)N2CCC(NC(=O)C3CCC3)C2)n[nH]1 CHEMBL4059597 IC50 60.0 nM
CN(C)C/C=C/C(=O)Nc1cccc(C(OCCN2CCCCC2)c2cc3nccc(C(=O)O)c3s2)c1 CHEMBL4287599 IC50 60.0 nM
CC(C)c1c(N2CCCCC2)[nH]c2c(C#N)cnn2c1=O CHEMBL4534149 IC50 63.2 nM
CC(C)c1cc(C(=O)N2CCC(NC(=O)C3CC3)C2)n[nH]1 CHEMBL4060968 IC50 65.0 nM
CCCCCCN(C)Cc1cccc(-c2[nH]c3c(C#N)cnn3c(=O)c2C(C)C)c1 CHEMBL4436444 IC50 65.3 nM
CNC(=O)c1c(O)c2ccncc2[nH]c1=O CHEMBL4471064 IC50 70.0 nM
O=C(O)c1ccnc(-n2nccc2OCc2ccc(Cl)cc2OCC2CC2)c1 CHEMBL4225515 IC50 75.0 nM
CC(C)c1c(N(C)C)[nH]c2c(C#N)cnn2c1=O CHEMBL4451492 IC50 76.6 nM
Cc1cnn(-c2cc(C(=O)O)ccn2)c1OCc1ccc(F)cc1 CHEMBL4225810 IC50 77.0 nM
CCCCCN(C)CCCCC(=O)N(O)CCC(=O)O CHEMBL3590426 IC50 79.0 nM
CC(C)c1cc(C(=O)N2CC[C@@H](NC(=O)NC3CC3)C2)n[nH]1 CHEMBL5206280 IC50 79.0 nM
O=C(O)c1ccnc(-n2ncc(CCO)c2OCc2ccc(F)cc2)c1 CHEMBL3786579 IC50 80.0 nM
CC(C)c1cc(C(=O)N2CCC(NC(=O)c3ccccc3)C2)[nH]n1 CHEMBL4071387 IC50 99.0 nM
CC(C)c1cc(C(=O)N2CC[C@@H](NC(=O)c3ccccc3)C2)[nH]n1 CHEMBL5286372 IC50 99.0 nM
COc1ccc(-c2c(-c3cc(C(=O)O)ccn3)ncn2C)cc1 CHEMBL3786803 IC50 100.0 nM
Cn1cnc(-c2cc(-c3nnn[nH]3)ccn2)c1 CHEMBL3786225 IC50 100.0 nM
O=C(O)c1ccncc1NCC12CC3CC(CC(C3)C1)C2 CHEMBL3786596 IC50 100.0 nM
O=C(O)c1ccnc2cc(OCc3ccc(Cl)c(OCC4CC4)c3)[nH]c12 CHEMBL3787548 IC50 100.0 nM
O=C(O)c1ccnc2cc(OCc3ccc(Cl)c(OC(F)(F)F)c3)[nH]c12 CHEMBL3785421 IC50 100.0 nM
COC(=O)c1ccnc(-n2nccc2OCc2ccc(Cl)cc2)c1 CHEMBL3786987 IC50 100.0 nM
O=C(O)c1ccncc1Nc1nn(C2CCCC2)c2ccc(F)cc12 CHEMBL3785470 IC50 100.0 nM
Cn1nc(Nc2cnccc2C(=O)O)c2cccnc21 CHEMBL3786617 IC50 100.0 nM
Cc1cc(O)n(-c2cc(C(=O)O)ccn2)n1 CHEMBL4286275 IC50 100.0 nM
Cc1nn(-c2cc(C(=O)O)ccn2)c(O)c1C CHEMBL4292883 IC50 100.0 nM
CCCc1cc(O)n(-c2cc(C(=O)O)ccn2)n1 CHEMBL4287794 IC50 100.0 nM
O=C(O)c1ccnc(-n2nc(Cc3ccccc3)cc2O)c1 CHEMBL4276814 IC50 100.0 nM
COCc1cc(O)n(-c2cc(C(=O)O)ccn2)n1 CHEMBL4277756 IC50 100.0 nM
Cc1ccc(-c2ccnn2-c2cc(C(=O)O)ccn2)cc1 CHEMBL4227799 IC50 100.0 nM
Cc1cccc(-c2ccnn2-c2cc(C(=O)O)ccn2)c1 CHEMBL4283282 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2-c2ccc(F)cc2F)c1 CHEMBL4228902 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2-c2ccc(F)c(F)c2)c1 CHEMBL4228839 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2-c2cccc(F)c2)c1 CHEMBL4227668 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2-c2cccc(O)c2)c1 CHEMBL4228384 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2-c2ccc(O)cc2)c1 CHEMBL4227544 IC50 100.0 nM
CS(=O)(=O)c1ccc(-c2ccnn2-c2cc(C(=O)O)ccn2)cc1 CHEMBL4227075 IC50 100.0 nM
COc1cc(-c2ccnn2-c2cc(C(=O)O)ccn2)ccc1C CHEMBL4226861 IC50 100.0 nM
COc1cc(-c2ccnn2-c2cc(C(=O)O)ccn2)ccc1Cl CHEMBL4225665 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2-c2ccc(Cl)c(O)c2)c1 CHEMBL4288537 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2-c2ccc3cn[nH]c3c2)c1 CHEMBL4284855 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2-c2ccc(F)cc2)c1 CHEMBL4226553 IC50 100.0 nM
CS(=O)(=O)c1ccc(-c2ccnn2-c2cc(C(=O)O)ccn2)cc1O CHEMBL4280506 IC50 100.0 nM
O=C(O)c1ccnc(-n2ccc(CCc3ccccc3)n2)c1 CHEMBL4281202 IC50 100.0 nM
Cc1c(-c2ccccc2)cnn1-c1cc(C(=O)O)ccn1 CHEMBL4286290 IC50 100.0 nM
Cc1cc(OCc2ccccc2)n(-c2cc(C(=O)O)ccn2)n1 CHEMBL4287797 IC50 100.0 nM
CCCCc1ccn(-c2cc(C(=O)O)ccn2)n1 CHEMBL4287102 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2-c2ccc(Br)cc2)c1 CHEMBL4282036 IC50 100.0 nM
CN(C)c1ccc(-c2ccnn2-c2cc(C(=O)O)ccn2)cc1 CHEMBL4283065 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2OCc2ccc3cn[nH]c3c2)c1 CHEMBL4285840 IC50 100.0 nM
CCCCOc1cc(Cl)ccc1COc1ccnn1-c1cc(C(=O)O)ccn1 CHEMBL4287296 IC50 100.0 nM
CC(C)COc1cc(Cl)ccc1COc1ccnn1-c1cc(C(=O)O)ccn1 CHEMBL4281159 IC50 100.0 nM
CC(C)Oc1cc(Cl)ccc1COc1ccnn1-c1cc(C(=O)O)ccn1 CHEMBL4282124 IC50 100.0 nM
CCC(C)Oc1cc(Cl)ccc1COc1ccnn1-c1cc(C(=O)O)ccn1 CHEMBL4292444 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2OCc2ccc(Cl)cc2OCc2ccc(F)cc2)c1 CHEMBL4289695 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2OCc2ccc(F)cc2/C=C/c2ccc(F)cc2)c1 CHEMBL4291083 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2OCc2ccc(Cl)cc2/C=C/c2ccc(F)cc2)c1 CHEMBL4294132 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2OCc2ccc(F)cc2CCc2ccc(F)cc2)c1 CHEMBL4295216 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2OCc2ccc(Cl)cc2CCc2ccc(F)cc2)c1 CHEMBL4278760 IC50 100.0 nM
CC1(C)Cc2cccc(COc3ccnn3-c3cc(C(=O)O)ccn3)c2O1 CHEMBL4285045 IC50 100.0 nM
CCc1cc(Cl)ccc1COc1ccnn1-c1cc(C(=O)O)ccn1 CHEMBL4285436 IC50 100.0 nM
Cc1ccc(COc2ccnn2-c2cc(C(=O)O)ccn2)c(Cl)c1 CHEMBL4283926 IC50 100.0 nM
CCc1cc(C)ccc1COc1ccnn1-c1cc(C(=O)O)ccn1 CHEMBL4279612 IC50 100.0 nM
CC(Oc1cc(Cl)ccc1COc1ccnn1-c1cc(C(=O)O)ccn1)c1ccccc1 CHEMBL4293050 IC50 100.0 nM
CC(Oc1cc(F)ccc1COc1ccnn1-c1cc(C(=O)O)ccn1)c1ccccc1 CHEMBL4294087 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2OCc2ccc(Cl)c(OCC3CC3)c2)c1 CHEMBL4287561 IC50 100.0 nM
Cc1cc(Br)ccc1COc1ccnn1-c1cc(C(=O)O)ccn1 CHEMBL4281578 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2OC2CCc3cc(F)ccc32)c1 CHEMBL4291175 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2OC2CCc3cc(Cl)ccc32)c1 CHEMBL4287020 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2OC2CCCc3cc(F)ccc32)c1 CHEMBL4287394 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2OC2CCCc3cc(Cl)ccc32)c1 CHEMBL4288436 IC50 100.0 nM
CCc1ccc(COc2ccnn2-c2cc(C(=O)O)ccn2)c(Cl)c1 CHEMBL4291477 IC50 100.0 nM
CCc1ccc(COc2ccnn2-c2cc(C(=O)O)ccn2)c(F)c1 CHEMBL4292524 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2OCc2ccc(C3CC3)cc2Cl)c1 CHEMBL4294656 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2OCc2ccc(C3CC3)cc2F)c1 CHEMBL4279637 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2OCc2ccc(C3CC3)c(Cl)c2)c1 CHEMBL4283497 IC50 100.0 nM
O=C(O)c1ccnc(-n2nccc2OCc2ccc(C3CC3)c(F)c2)c1 CHEMBL4287567 IC50 100.0 nM
Cn1cnc(-c2cc(C(=O)O)ccn2)c1-c1ccc(C(C)(C)C)cc1 CHEMBL4283867 IC50 100.0 nM
CNC(=O)c1cccc(-c2c(-c3cc(C(=O)O)ccn3)ncn2C)c1 CHEMBL4290866 IC50 100.0 nM
Cn1cnc(-c2cc(C(=O)O)ccn2)c1-c1cccc(CO)c1 CHEMBL4293936 IC50 100.0 nM
Cn1cnc(-c2cc(C(=O)O)ccn2)c1-c1ccc(OC(F)(F)F)cc1 CHEMBL4288145 IC50 100.0 nM
CCOc1ccc(-c2c(-c3cc(C(=O)O)ccn3)ncn2C)cc1 CHEMBL4285443 IC50 100.0 nM
O=C(O)c1ccnc(-c2cn(CCn3cccn3)cn2)c1 CHEMBL4290028 IC50 100.0 nM
Cn1cnc(-c2cc(C(=O)O)ccn2)c1-c1ccc(F)cc1OCC1CC1 CHEMBL4291787 IC50 100.0 nM
Clc1ccccc1Cn1cnc(-c2cc(-c3nn[nH]n3)ccn2)c1 CHEMBL4277136 IC50 100.0 nM
FC(F)(F)c1ccccc1CCn1cnc(-c2cc(-c3nn[nH]n3)ccn2)c1 CHEMBL4285453 IC50 100.0 nM
Clc1ccccc1CCn1cnc(-c2cc(-c3nn[nH]n3)ccn2)c1 CHEMBL4284366 IC50 100.0 nM
CCC(c1ccccc1)n1cnc(-c2cc(-c3nn[nH]n3)ccn2)c1 CHEMBL4288012 IC50 100.0 nM
CC(C)C(c1ccccc1)n1cnc(-c2cc(-c3nn[nH]n3)ccn2)c1 CHEMBL4289071 IC50 100.0 nM
Cn1cnc(-c2cc(-c3nn[nH]n3)ccn2)c1-c1ccc(F)cc1OCC1CC1 CHEMBL4286301 IC50 100.0 nM
FC(F)(F)c1cccc(Cn2cnc(-c3cc(-c4nn[nH]n4)ccn3)c2)c1Cl CHEMBL4290010 IC50 100.0 nM
O=C(O)c1ccnc(NCc2cccc(F)c2)c1 CHEMBL5268189 IC50 100.0 nM
Cc1cc(-c2cnn(Cc3ccccc3)c2)cc(C2CCN(C(=O)c3cc(C(C)C)n[nH]3)C2)n1 CHEMBL4077454 IC50 105.0 nM
Cc1cccc(-c2cc(C)nc(C3CCN(C(=O)c4cc(C(C)C)n[nH]4)C3)c2)c1 CHEMBL4071397 IC50 122.0 nM
Cc1cc(Oc2ccccc2)cc(C2CCN(C(=O)c3cc(C(C)C)n[nH]3)C2)n1 CHEMBL4092189 IC50 128.0 nM
COC1=C2C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(\C)[C@H](OC(N)=O)[C@@H](OC)/C=C\C=C(/C)C(=O)NC(=CC1=O)C2=O CHEMBL278315 IC50 130.0 nM
CO[C@H]1/C=C\C=C(/C)C(=O)NC2=CC(=O)C(NCCN(C)C)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(\C)[C@@H]1OC(N)=O)C2=O CHEMBL383824 IC50 130.0 nM
C=CCNC1=C2C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(\C)[C@H](OC(N)=O)[C@@H](OC)/C=C\C=C(/C)C(=O)NC(=CC1=O)C2=O CHEMBL109480 IC50 130.0 nM
CN1CCCC1CCOC(c1cc2nccc(C(=O)O)c2[nH]1)c1ccccc1Cl CHEMBL4081571 Kd 150.0 nM
Cc1cc(-c2cnn(C)c2)cc(C2CCN(C(=O)c3cc(C(C)C)n[nH]3)C2)n1 CHEMBL4083572 IC50 160.0 nM
O=c1[nH]c(C(F)(F)F)nc2cnccc12 CHEMBL4445747 IC50 160.0 nM
Cc1cc(-c2cnn(C)c2)cc([C@@H]2CCN(C(=O)c3cc(C(C)C)n[nH]3)C2)n1 CHEMBL5287732 IC50 160.0 nM
CCCCCCN(C)CCNC(=O)c1ccnc(-c2cc(C(=O)O)ccn2)c1 CHEMBL4446067 IC50 170.0 nM
CCCCCCN(C)Cc1cc(-c2[nH]c3c(C#N)cnn3c(=O)c2C(C)C)cs1 CHEMBL4556977 IC50 179.0 nM
O=C(O)c1ccnc2cc(C(OCCN3CCCCC3)c3ccccc3Cl)[nH]c12 CHEMBL4090351 Kd 180.0 nM
CC(Oc1ccnn1-c1cc(C(=O)O)ccn1)c1ccc(F)cc1 CHEMBL4225839 IC50 180.0 nM
Cc1ccc(-c2cn3cc(C)ccc3n2)cc1 CHEMBL1440422 IC50 190.0 nM
CC(C)c1cc(C(=O)N2CCC(NC(=O)C(C)(C)C)C2)n[nH]1 CHEMBL4089789 IC50 198.0 nM
CC(C)C(=O)NC1CCN(C(=O)c2cc(C(C)C)[nH]n2)C1 CHEMBL4061676 IC50 204.0 nM
CCc1c(-c2ccccc2C)[nH]c2c(C#N)cnn2c1=O CHEMBL4586086 IC50 206.0 nM
O=C(O)c1ccnc2cc(C(OCCN3CCC(F)(F)CC3)c3ccccc3Cl)[nH]c12 CHEMBL4070992 Kd 210.0 nM
CCc1c(C)n(C)c2c(C#N)cnn2c1=O CHEMBL4520731 IC50 214.0 nM
NNc1nccc(C(=O)O)n1 CHEMBL3793278 IC50 220.0 nM
O=C(O)c1ccnc2cc([C@H](OCCN3CCCCC3)c3ccccc3Cl)[nH]c12 CHEMBL4062359 Kd 220.0 nM
CCc1c(O)c2ccncc2[nH]c1=O CHEMBL4465724 IC50 230.0 nM
Clc1ccc(N/N=C(\c2ccccc2)c2ccccn2)nc1 CHEMBL1982368 IC50 230.0 nM
CCc1c(C)[nH]c2c(C#N)c(C)nn2c1=O CHEMBL4469878 IC50 237.0 nM
CCC1=C(C)NC2=C(C#N)C(C)=CC2C1=O CHEMBL5269002 IC50 238.0 nM
O=C(O)c1ccnc(-n2nccc2OCc2ccc(C(F)(F)F)cc2)c1 CHEMBL4228544 IC50 240.0 nM
O=C(O)c1ccnc2cc(C(OCCCN3CCCCC3)c3ccccc3Cl)[nH]c12 CHEMBL4066179 Kd 250.0 nM
O=C(O)c1ccnc(-n2nccc2OCc2ccc(C3CC3)cc2)c1 CHEMBL4224779 IC50 250.0 nM
CCC(=O)NC1CCN(C(=O)c2cc(C(C)C)[nH]n2)C1 CHEMBL4081928 IC50 251.0 nM
CN1CCCC1CCOC(c1cc2nccc(C(=O)O)c2s1)c1ccccc1Cl CHEMBL4284220 Kd 260.0 nM
Cc1cc(-c2ccoc2)cc(C2CCN(C(=O)c3cc(C(C)C)n[nH]3)C2)n1 CHEMBL4065511 IC50 265.0 nM
O=C(O)c1ccnc(-n2nccc2OCc2ccccc2F)c1 CHEMBL4227508 IC50 270.0 nM
CCOC(=O)c1ccnc(CNCC(=O)N(CC)CCN(C)C)c1 CHEMBL3786593 IC50 303.0 nM
COC(=O)c1c(-c2ccccc2)[nH]c2c(C#N)cnn2c1=O CHEMBL4483632 IC50 319.0 nM
CN(C)C/C=C/C(=O)Nc1cccc(C(OCCN2CCCCC2)c2cc3nccc(C(=O)O)c3[nH]2)c1 CHEMBL5276550 IC50 320.0 nM
CCc1c(C)nc2c(C#N)cnn2c1OC CHEMBL3786528 IC50 324.0 nM
Cc1cc(-c2cnn(C)c2)cc(C2CCN(C(=O)c3cc(C4CC4)n[nH]3)C2)n1 CHEMBL4069572 IC50 357.0 nM
CC(C)NC(=O)c1c(O)c2ccncc2[nH]c1=O CHEMBL4520567 IC50 400.0 nM
Cn1ccnc1CCOC(c1cc2nccc(C(=O)O)c2[nH]1)c1ccccc1Cl CHEMBL4077310 Kd 410.0 nM
O=C(O)c1ccnc(-n2nccc2OCc2cccc(F)c2)c1 CHEMBL4228781 IC50 430.0 nM
CCCc1cc(C(=O)N2CCC(c3cc(-c4cnn(C)c4)cc(C)n3)C2)[nH]n1 CHEMBL4090588 IC50 458.0 nM
Cc1cc(-c2cccnc2)cc(C2CCN(C(=O)c3cc(C(C)C)n[nH]3)C2)n1 CHEMBL4093169 IC50 469.0 nM
O=C(O)c1ccnc2cc(C(OCC3CCC(F)(F)CC3)c3ccccc3Cl)[nH]c12 CHEMBL4059617 Kd 470.0 nM
Nc1cccc(C(OCCN2CCCCC2)c2cc3nccc(C(=O)O)c3s2)c1 CHEMBL4276959 IC50 490.0 nM
CCCOC(c1cc2nccc(C(=O)O)c2[nH]1)c1ccccc1Cl CHEMBL4100530 Kd 530.0 nM
O=C(O)c1ccnc(-n2nccc2OCc2ccccc2)c1 CHEMBL4225358 IC50 550.0 nM
Cc1cc(=O)n2ncc(C#N)c2[nH]1 CHEMBL4448240 IC50 649.0 nM
CCN(C)C(=O)c1c(O)c2ccncc2[nH]c1=O CHEMBL4578848 IC50 700.0 nM
CCNC(=O)c1[nH]c2c(C#N)cnn2c(=O)c1CC CHEMBL4452124 IC50 712.0 nM
CC(C)c1cc(C(=O)N2CCC(n3cc(Br)cn3)C2)[nH]n1 CHEMBL4066567 IC50 727.0 nM
O=C(O)c1ccnc(C(=O)O)c1 CHEMBL316034 IC50 760.0 nM
Cc1cc(-c2cnn(C)c2)cc([C@H]2CCN(C(=O)c3cc(C(C)C)n[nH]3)C2)n1 CHEMBL5283892 IC50 770.0 nM
C[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=S)Nc1ccc(C2=C3C=CC(O)=CC3Oc3cc(O)ccc32)c(C(=O)O)c1)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(=O)O CHEMBL4173016 Kd 800.0 nM
C[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCC[N+](C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=S)Nc1ccc(C2=C3C=CC(O)=CC3Oc3cc(O)ccc32)c(C(=O)O)c1)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(=O)O CHEMBL4165111 Kd 800.0 nM
CCN(CCN(C)C)C(=O)CNCc1cc(C(=O)Oc2ccc(OC(C)C)cc2OC(C)C)ccn1 CHEMBL5272568 IC50 830.0 nM
CCc1cc(C(=O)N2CCC(c3cc(-c4cnn(C)c4)cc(C)n3)C2)[nH]n1 CHEMBL4080293 IC50 878.0 nM
N#Cc1cnn2c(=O)c3c([nH]c12)CCCC3 CHEMBL3786862 IC50 878.0 nM
Cc1cc(-c2cnn(C)c2)cc(C2CCN(C(=O)c3cc(C(C)(C)C)n[nH]3)C2)n1 CHEMBL4102674 IC50 897.0 nM
COc1cc(COc2cc3nccc(C(=O)O)c3[nH]2)ccc1Cl CHEMBL3786108 IC50 1000.0 nM
Cn1cnc(-c2cc(C(=O)O)ccn2)c1-c1ccc(OCC2CC2)cc1 CHEMBL3787664 IC50 1000.0 nM
Cc1nn(-c2cc(C(=O)O)ccn2)c(O)c1-c1ccccc1 CHEMBL4293636 IC50 1000.0 nM
O=C(O)c1ccnc(-n2nc(-c3ccccc3F)cc2O)c1 CHEMBL4288830 IC50 1000.0 nM
O=C(O)c1ccnc(-n2nc(-c3ccccc3Cl)cc2O)c1 CHEMBL4279127 IC50 1000.0 nM
O=C(O)c1ccnc(-n2nc(COc3ccccc3)cc2O)c1 CHEMBL4278777 IC50 1000.0 nM
O=C(O)c1ccnc(-n2nccc2-c2ccccc2)c1 CHEMBL4226822 IC50 1000.0 nM
Cc1ccc(-c2cc(C)nn2-c2cc(C(=O)O)ccn2)cc1 CHEMBL4279432 IC50 1000.0 nM
CCc1cc(-c2ccc(C)cc2)n(-c2cc(C(=O)O)ccn2)n1 CHEMBL4284610 IC50 1000.0 nM
Cc1ccnn1-c1cc(C(=O)O)ccn1 CHEMBL4280874 IC50 1000.0 nM
O=C(O)c1ccnc(-n2ccc(Cc3ccccc3)n2)c1 CHEMBL4284987 IC50 1000.0 nM
O=C(O)c1ccnc(-n2nccc2CCc2ccccc2)c1 CHEMBL4282258 IC50 1000.0 nM
COc1cc(C)nn1-c1cc(C(=O)O)ccn1 CHEMBL4285308 IC50 1000.0 nM
CCCCc1ccnn1-c1cc(C(=O)O)ccn1 CHEMBL4286063 IC50 1000.0 nM
O=C(O)c1ccnc(-n2nc(-c3ccc(Cl)cc3)cc2O)c1 CHEMBL4288934 IC50 1000.0 nM
O=C(O)c1ccnc(-n2nc(-c3cccc(Cl)c3)cc2O)c1 CHEMBL4287890 IC50 1000.0 nM
O=C(O)c1ccnc(-n2nc(C3CCCC3)cc2O)c1 CHEMBL4284863 IC50 1000.0 nM
O=C(O)c1ccnc(-c2cn(CCN3CCOCC3)cn2)c1 CHEMBL4284437 IC50 1000.0 nM