CCCCCCN(C)Cc1ccc(-c2[nH]c3c(C#N)cnn3c(=O)c2C(C)C)cc1 CHEMBL4536443 IC50 5.84 nM
CCCCCCN(C)CCc1ccc(-c2[nH]c3c(C#N)cnn3c(=O)c2C(C)C)cc1 CHEMBL4542928 IC50 6.24 nM
CCCCCCN(C)CCn1cc(-c2cc(C(=O)O)ccn2)nn1 CHEMBL5199483 IC50 8.8 nM
Nc1nc(-c2cc(C(=O)O)ccn2)cs1 CHEMBL3774692 IC50 12.0 nM
CN(C)CCc1cccc(C2CCN(CCc3cnn(-c4nccc5c(=O)[nH]cnc45)c3)CC2)c1 CHEMBL4438830 IC50 14.0 nM
CC(C)c1c(-c2ccccc2)[nH]c2c(C#N)cnn2c1=O CHEMBL4454253 IC50 14.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(Cc5ccc(F)cc5)CC4)cn3)nccc12 CHEMBL3775040 IC50 21.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(Cc5ccc6c(c5)OCO6)CC4)cn3)nccc12 CHEMBL3775451 IC50 21.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(Cc5ccc(C(F)(F)F)cc5)CC4)cn3)nccc12 CHEMBL3775516 IC50 22.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(Cc5ccc(Cl)cc5)CC4)cn3)nccc12 CHEMBL3775899 IC50 23.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(Cc5ccc(Cl)c(Cl)c5)CC4)cn3)nccc12 CHEMBL3774940 IC50 23.0 nM
N#Cc1ccc(C2CCN(CCc3cnn(-c4nccc5c(=O)[nH]cnc45)c3)CC2)cc1 CHEMBL3775814 IC50 24.0 nM
COc1ccc(-n2cc(C(=O)NCC(C)(C)N3CCOCC3)c(-c3ccccc3)n2)cc1 CHEMBL4782583 IC50 24.8 nM
Cc1cc(-c2cnn(C)c2)cc([C@@H]2CCN(C(=O)c3cc(C(C)C)n[nH]3)C2)n1 CHEMBL5287732 IC50 25.0 nM
CCN(CCN(C)C)C(=O)CNCc1cc(C(N)=O)ccn1 CHEMBL4078388 IC50 27.0 nM
COC(=O)c1ccnc(-c2cc(C(=O)O)ccn2)c1 CHEMBL3108956 IC50 30.0 nM
O=C([O-])c1ccnc(CNCc2ccco2)c1 CHEMBL3775362 IC50 30.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccc(CN6CCCC6)c5)CC4)cn3)nccc12 CHEMBL4592908 IC50 30.0 nM
CS(=O)(=O)c1ccc(C2CCN(CCc3cnn(-c4nccc5c(=O)[nH]cnc45)c3)CC2)cc1 CHEMBL3774665 IC50 32.0 nM
COc1ccc(C2CCN(CCc3cnn(-c4nccc5c(=O)[nH]cnc45)c3)CC2)cc1 CHEMBL3775545 IC50 34.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccc(CCN6CCOCC6)c5)CC4)cn3)nccc12 CHEMBL4440395 IC50 35.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cc(CN6CCCC6)cc(C(F)(F)F)c5)CC4)cn3)nccc12 CHEMBL4516101 IC50 38.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(Cc5ccccc5)CC4)cn3)nccc12 CHEMBL3774392 IC50 41.0 nM
COc1cccc(CC2CCN(CCc3cnn(-c4nccc5c(=O)[nH]cnc45)c3)CC2)c1 CHEMBL3775465 IC50 41.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccs5)CC4)cn3)nccc12 CHEMBL3775668 IC50 46.0 nM
CN(C)CCc1ccc(C2CCN(CCc3cnn(-c4nccc5c(=O)[nH]cnc45)c3)CC2)cc1 CHEMBL4585876 IC50 48.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(Cc5cccnc5)CC4)cn3)nccc12 CHEMBL3775956 IC50 50.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5ccncc5)CC4)cn3)nccc12 CHEMBL3775277 IC50 50.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cc(Cl)cc(Cl)c5)CC4)cn3)nccc12 CHEMBL3775894 IC50 51.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5ccc(F)cc5)CC4)cn3)nccc12 CHEMBL3775953 IC50 52.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5ccc(CCN6CCOCC6)cc5)CC4)cn3)nccc12 CHEMBL4466130 IC50 53.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5ccc(F)cc5F)CC4)cn3)nccc12 CHEMBL3775121 IC50 54.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccc(-c6cncnc6)c5)CC4)cn3)nccc12 CHEMBL4558689 IC50 54.0 nM
CC(C)c1cc(C(=O)N2CC[C@@H](NC(=O)C3CC3)C2)[nH]n1 CHEMBL4088737 IC50 55.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(Cc5noc(C6CC6)n5)CC4)cn3)nccc12 CHEMBL3775130 IC50 57.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccc(-c6cccnc6)c5)CC4)cn3)nccc12 CHEMBL4567766 IC50 59.0 nM
CCN(CCN(C)C)C(=O)CNCc1cc(C(=O)O)ccn1 CHEMBL3787669 IC50 59.0 nM
O=C([O-])c1ccnc(CNCc2ccccc2)c1 CHEMBL3775095 IC50 60.0 nM
CC(C)(C)c1cccc(C2CCN(CCc3cnn(-c4nccc5c(=O)[nH]cnc45)c3)CC2)c1 CHEMBL4520178 IC50 63.0 nM
O=c1[nH]c(Oc2cnn(Cc3ccccc3)c2)nc2cnccc12 CHEMBL3771180 pIC50 63.1 nM
CN(CCCc1cnn(-c2nccc3c(=O)[nH]cnc23)c1)Cc1ccc(C#N)cc1 CHEMBL3774922 IC50 64.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccc(Cl)c5)CC4)cn3)nccc12 CHEMBL3774537 IC50 65.0 nM
CC(C)c1c(-c2cnn(C(C)(C)C)c2)[nH]c2c(C#N)cnn2c1=O CHEMBL3785583 IC50 65.5 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5ccc(Cl)cc5)CC4)cn3)nccc12 CHEMBL3775977 IC50 67.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccc(C(F)(F)F)c5)CC4)cn3)nccc12 CHEMBL3775548 IC50 70.0 nM
CN(CCc1cnn(-c2nccc3c(=O)[nH]cnc23)c1)Cc1ccc(C#N)cc1 CHEMBL3775135 IC50 76.0 nM
CN(CCc1cnn(-c2nccc3c(=O)[nH]cnc23)c1)Cc1ccc(F)cc1 CHEMBL3774747 IC50 78.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccc(-c6ccccn6)c5)CC4)cn3)nccc12 CHEMBL4561958 IC50 79.0 nM
O=C(O)c1ccncc1NCc1ccco1 CHEMBL3775237 IC50 79.0 nM
O=c1[nH]c(Oc2cnn(CC3CCCCC3)c2)nc2cnccc12 CHEMBL3771198 pIC50 79.43 nM
CN(CCc1cnn(-c2nccc3c(=O)[nH]cnc23)c1)Cc1ccc(Cl)c(Cl)c1 CHEMBL3775145 IC50 80.0 nM
CCN1CCC(c2cnn(-c3nccc4c(=O)[nH]cnc34)c2)CC1 CHEMBL4560811 IC50 81.0 nM
COc1cccc(C2CCN(CCc3cnn(-c4nccc5c(=O)[nH]cnc45)c3)CC2)c1 CHEMBL4538741 IC50 86.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccc(F)c5)CC4)cn3)nccc12 CHEMBL4447515 IC50 96.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cc(CCN6CCOCC6)cc(C(F)(F)F)c5)CC4)cn3)nccc12 CHEMBL4553540 IC50 96.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5ccc(-c6ccncc6)cc5)CC4)cn3)nccc12 CHEMBL4590283 IC50 108.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccc(CN6CCOCC6)c5)CC4)cn3)nccc12 CHEMBL4549505 IC50 113.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5ccccc5Cl)CC4)cn3)nccc12 CHEMBL3775823 IC50 119.0 nM
O=C(O)c1ccnc(-c2cscn2)c1 CHEMBL3775933 IC50 122.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC5(CCc6ccccc65)CC4)cn3)nccc12 CHEMBL4449500 IC50 123.0 nM
CC(C)c1ccc(Oc2nc3cnccc3c(=O)[nH]2)cn1 CHEMBL3769511 pIC50 125.89 nM
O=c1[nH]c(Oc2cnn(C3CCCC3)c2)nc2cnccc12 CHEMBL3769724 pIC50 125.89 nM
Cc1ccsc1CNc1cnccc1C(=O)O CHEMBL3775889 pIC50 125.89 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cc(F)cc(F)c5)CC4)cn3)nccc12 CHEMBL3774456 IC50 126.0 nM
O=c1[nH]cnc2c(-n3cc(C4CCN(C5CCCC5)CC4)cn3)nccc12 CHEMBL4529932 IC50 132.0 nM
CN(CCc1cnn(-c2nccc3c(=O)[nH]cnc23)c1)Cc1ccc(S(C)(=O)=O)cc1 CHEMBL3774701 IC50 136.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5ccccc5)CC4)cn3)nccc12 CHEMBL3774457 IC50 142.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCCC4)cn3)nccc12 CHEMBL3774710 IC50 150.0 nM
CC(C)c1cccc(C2CCN(CCc3cnn(-c4nccc5c(=O)[nH]cnc45)c3)CC2)c1 CHEMBL4476629 IC50 156.0 nM
CN1CCC(c2cnn(-c3nccc4c(=O)[nH]cnc34)c2)CC1 CHEMBL4483780 IC50 163.0 nM
N#Cc1c(O)c2ccncc2[nH]c1=O CHEMBL4560583 IC50 170.0 nM
N[C@@H]1C[C@H]1c1ccc(NC(=O)c2ccnc(-c3cc(C(=O)O)ccn3)c2)cc1 CHEMBL3108958 IC50 190.0 nM
O=c1[nH]c(Oc2ccc(Cl)c(O)c2)nc2cnccc12 CHEMBL3770740 pIC50 199.53 nM
O=C(O)c1ccc(O)c2ncccc12 CHEMBL1230640 IC50 200.0 nM
O=c1[nH]cnc2c(-n3cc(C4CCN(CC5CCC5)CC4)cn3)nccc12 CHEMBL4525269 IC50 202.0 nM
CC(C)COc1cccc(C2CCN(CCc3cnn(-c4nccc5c(=O)[nH]cnc45)c3)CC2)c1 CHEMBL4473678 IC50 213.0 nM
Cc1ccc(C)c2c1CCC21CCN(CCc2cnn(-c3nccc4c(=O)[nH]cnc34)c2)CC1 CHEMBL4435185 IC50 214.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5ccc(-c6cccnc6)cc5)CC4)cn3)nccc12 CHEMBL4559561 IC50 246.0 nM
CCN(CCN(C)C)C(=O)CNCc1cc(CNC(=O)C(F)(F)F)ccn1 CHEMBL3786409 IC50 250.0 nM
O=C1CCCN1c1ccc(C2CCN(CCc3cnn(-c4nccc5c(=O)[nH]cnc45)c3)CC2)cc1 CHEMBL4522584 IC50 313.0 nM
Nc1nc(-c2nccc3c(=O)[nH]cnc23)cs1 CHEMBL3774798 IC50 331.0 nM
CN(C)CCc1cnn(-c2nccc3c(=O)[nH]cnc23)c1 CHEMBL3775454 IC50 340.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCCCC4)cn3)nccc12 CHEMBL3775500 IC50 342.0 nM
CC(C)c1cc(C(=O)N2CC[C@@H](NC(=O)NC3CC3)C2)n[nH]1 CHEMBL5206280 IC50 353.0 nM
Cn1cc(CN2CCC(c3cnn(-c4nccc5c(=O)[nH]cnc45)c3)CC2)cn1 CHEMBL4483792 IC50 377.0 nM
O=c1[nH]cnc2c(CNCc3ccccc3)nccc12 CHEMBL3775615 IC50 440.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC5(CC4)OCc4ccccc45)cn3)nccc12 CHEMBL4464471 IC50 470.0 nM
NNC(=O)CCC(=O)O CHEMBL2164246 IC50 480.0 nM
O=C(O)c1ccnc(C(=O)O)c1 CHEMBL316034 pIC50 501.19 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5ccc(-c6cncnc6)cc5)CC4)cn3)nccc12 CHEMBL4438034 IC50 549.0 nM
CC(C)N1CCC(c2cnn(-c3nccc4c(=O)[nH]cnc34)c2)CC1 CHEMBL4455283 IC50 566.0 nM
O=c1[nH]cnc2c(-n3cc(C4CCN(CC5CC5)CC4)cn3)nccc12 CHEMBL4532069 IC50 571.0 nM
CC(C)c1c(-c2cnn(CCNC(=O)CCl)c2)[nH]c2c(C#N)cnn2c1=O CHEMBL5277258 IC50 571.0 nM
CCOC(=O)c1ccnc(CNCC(=O)N(CC)CCN(C)C)c1 CHEMBL3786593 IC50 580.0 nM
O=C(O)c1ccnc(-c2ccccn2)c1 CHEMBL3621852 pIC50 630.96 nM
CC(=O)N1CC(n2cc(-c3cc(C(=O)O)ccn3)nn2)C1 CHEMBL3621865 pIC50 630.96 nM
O=c1[nH]cnc2c(CNCc3ccco3)nccc12 CHEMBL3774765 IC50 730.0 nM
C=CC(=O)Nc1cccc(CN(C)CCc2cnn(-c3nccc4c(=O)[nH]cnc34)c2)c1 CHEMBL5277129 IC50 778.0 nM
O=c1[nH]cnc2c(-c3cscn3)nccc12 CHEMBL3775636 IC50 830.0 nM
CC(C)CN1CCC(c2cnn(-c3nccc4c(=O)[nH]cnc34)c2)CC1 CHEMBL4445652 IC50 856.0 nM
O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5ccc(-c6ccccn6)cc5)CC4)cn3)nccc12 CHEMBL4572027 IC50 896.0 nM
O=C(O)c1ccnc(CN2CCNCC2)c1 CHEMBL5275243 IC50 980.0 nM