Cn1ccnc1C(=O)Nc1cccc(Oc2ccc3c(/C=C/c4ccccn4)n[nH]c3c2)c1 CHEMBL3925855 Ki 0.02 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1336 Ki 0.021 nM
CN(C)c1ccc(/C=N/NC(=O)Cn2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)cc1 CHEMBL5189340 IC50 0.023 nM
Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)c(F)c3)c21 CHEMBL1254007 Ki 0.024 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5ccc(Cl)cc5)cccc4c3)c2cc1OC CHEMBL429743 IC50 0.03 nM
Cc1cnc(C(=O)Nc2cccc(Oc3ccc4c(/C=C/c5ccccc5)n[nH]c4c3)c2)s1 CHEMBL3898789 Ki 0.03 nM
CCn1nc(C)cc1C(=O)Nc1cccc(C(=O)c2ccc3c(/C=C/c4ccccn4)n[nH]c3c2)c1 CHEMBL3915607 Ki 0.03 nM
COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC CHEMBL2105717 IC50 0.035 nM
COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)c2cc1OC CHEMBL489326 IC50 0.035 nM
O=C(c1cccc(NC(=O)C2C[C@H]2c2ccccc2)c1)c1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL3899609 Ki 0.04 nM
O=C(NNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1)c1cccs1 CHEMBL3915544 Ki 0.04 nM
Cc1cc(C(=O)Nc2cc(Nc3ccc4c(/C=C/c5ccccn5)n[nH]c4c3)ccc2F)n(C)n1 CHEMBL3545335 Ki 0.04 nM
COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 CHEMBL24828 IC50 0.04 nM
O=C(Nc1cccc(C(=O)c2ccc3c(/C=C/c4ccccn4)n[nH]c3c2)c1)c1ccccc1 CHEMBL3952496 Ki 0.046 nM
O=C(c1cccc(NC(=O)c2ccc(Cl)s2)c1)c1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL3969695 Ki 0.05 nM
C=CCn1nc(C)cc1C(=O)Nc1cccc(C(=O)c2ccc3c(/C=C/c4ccccn4)n[nH]c3c2)c1 CHEMBL3904168 Ki 0.06 nM
Cc1cc(C(=O)Nc2cccc(C(=O)c3ccc4c(/C=C/c5ccccn5)n[nH]c4c3)c2)n(C)n1 CHEMBL3891895 Ki 0.06 nM
CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCCCS(C)(=O)=O)c(C(C)C)c23)c(F)cc1F CHEMBL195218 IC50 0.062 nM
O=C(c1cccc(NC(=O)c2cccc3[nH]ccc23)c1)c1ccc2c(/C=N/n3cccc3)n[nH]c2c1 CHEMBL3984370 Ki 0.062 nM
CN(c1cccc(NC(=O)c2ccccc2)c1)c1ccc2c(/C=C/c3ccc4c(c3)OCO4)n[nH]c2c1 CHEMBL3889841 Ki 0.08 nM
CCn1nc(C)cc1C(=O)Nc1cccc(Oc2ccc3c(/C=C/c4c[nH]cn4)n[nH]c3c2)c1 CHEMBL3954818 Ki 0.08 nM
COc1cc(C(=O)Nc2cccc(C(=O)c3ccc4c(/C=C/c5ccccn5)n[nH]c4c3)c2)cc(Cl)n1 CHEMBL3912174 Ki 0.08 nM
Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)ccc2C)n(C)n1 CHEMBL2180604 IC50 0.093 nM
O=C(c1cccc(NC(=O)c2cccc3[nH]ccc23)c1)c1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL3894732 Ki 0.093 nM
Cc1cc(C(=O)Nc2cccc(C(=O)c3ccc4c(/C=C/c5ccccn5)n[nH]c4c3)c2)n[nH]1 CHEMBL3891135 Ki 0.1 nM
CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL1289926 IC50 0.1 nM
O=C(c1cccc(NC(=O)c2ccccn2)c1)c1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL3959310 Ki 0.11 nM
O=C(Cc1cc(F)cc(F)c1)Nc1cccc(C(=O)c2ccc3c(/C=C/c4ccccn4)n[nH]c3c2)c1 CHEMBL3978730 Ki 0.11 nM
O=C(NCc1cccc(F)c1)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL3967940 Ki 0.11 nM
CONC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL3960830 Ki 0.11 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4ccc(C(F)(F)F)cc4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5411585 IC50 0.11 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)c3nn(-c4ccc(Cl)cc4)cc(C)c3=O)cc2)ccn1 CHEMBL5186748 IC50 0.12 nM
CCCCCCCCCCn1cc2c(N)ncnc2n1 CHEMBL363042 Ki 0.13 nM
CCn1nc(C)cc1C(=O)Nc1cc(C(=O)c2ccc3c(/C=C/c4ccccn4)n[nH]c3c2)ccc1C CHEMBL3930485 Ki 0.13 nM
O=C(Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1)c1cccn(-c2ccccc2)c1=O CHEMBL3093581 IC50 0.14 nM
CNC(=O)c1ccc(-c2ccc(NC(=O)Nc3cc(Br)cc(C(F)(F)F)c3)cc2)cn1 CHEMBL3586072 IC50 0.14 nM
O=C(Nc1cccc(Cl)c1)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL3972140 Ki 0.14 nM
CNC(=O)c1cc(-c2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL3586071 IC50 0.15 nM
Cc1cccc(C(=O)Nc2cccc(Oc3ccc4c(-c5cc6ccccc6[nH]5)n[nH]c4c3)c2)c1 CHEMBL3938388 Ki 0.15 nM
Cc1cc(NC(=O)c2c(NCc3ccncc3)ncn2C)ccc1C(F)(F)F CHEMBL238737 Ki 0.16 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC CHEMBL1289494 IC50 0.16 nM
Cn1ncc(NCc2ccncc2)c1C(=O)Nc1ccc(OC(F)(F)F)cc1 CHEMBL401040 Ki 0.17 nM
O=C(c1cccc(NC(=O)c2cccc3[nH]ccc23)c1)c1ccc2c(/C=C/c3ccccc3)n[nH]c2c1 CHEMBL3956824 Ki 0.18 nM
Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c2)n(C)n1 CHEMBL2348996 IC50 0.19 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4ccc(C)c(F)c4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5403470 IC50 0.19 nM
COc1cc(-c2cc(-c3ccc4ccccc4c3)nc(NN)c2C#N)ccc1O CHEMBL5399711 IC50 0.19 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5ccc(Cl)cc5)cccc4c3)c2cc1C(C)=O CHEMBL1242387 pIC50 0.1995 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5ccccc5)cccc4c3)c2cc1OC CHEMBL272824 pIC50 0.1995 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5ccon5)cccc4c3)c2cc1OC CHEMBL409538 pIC50 0.1995 nM
COc1cc2nccc(Oc3ccc4c(c3)OCCN4C(=O)Nc3ccc(C)cc3)c2cc1OC CHEMBL411630 pIC50 0.1995 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4)cc3)c2cc1OC CHEMBL368252 IC50 0.2 nM
COc1ccccc1NC(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cc1 CHEMBL426047 IC50 0.2 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(C)c4)cc3)c2cc1OC CHEMBL369760 IC50 0.2 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(Cl)cc4)cc3)c2cc1OC CHEMBL179165 IC50 0.2 nM
COc1cc2nccc(Oc3ccc4[nH]c(Nc5ccc(Cl)c(CN6CCN(C)CC6)c5)nc4c3)c2cc1OC CHEMBL427837 Ki 0.2 nM
Cn1cnc(NCc2ccncc2)c1C(=O)Nc1ccc(C(C)(C)C)cc1 CHEMBL393779 Ki 0.2 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5ccc(Cl)cc5)cccc4c3)c2cc1C(N)=O CHEMBL409512 IC50 0.2 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 0.2 nM
CNC(=O)c1ccccc1Sc1ccc2c(CCc3ccccn3)n[nH]c2c1 CHEMBL3939307 IC50 0.2 nM
Cn1nc(C(C)(C)C)cc1C(=O)Nc1cccc(C(=O)c2ccc3c(/C=C/c4ccccn4)n[nH]c3c2)c1 CHEMBL3915626 Ki 0.2 nM
C=C(c1cccc(NC(=O)c2ncc(C)s2)c1)c1ccc2c(/C=C/c3ccccc3)n[nH]c2c1 CHEMBL3914057 Ki 0.2 nM
O=C(Nc1ccc(-c2cccnc2)cc1)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL3586057 IC50 0.22 nM
Cc1ccc2cc(NC(=O)c3ccccc3Sc3ccc4c(/C=C/c5ccccc5)n[nH]c4c3)ccc2n1 CHEMBL3966821 Ki 0.22 nM
C/C=C/C(=O)Nc1cccc(C(=O)c2ccc3c(/C=C/c4ccccn4)n[nH]c3c2)c1 CHEMBL3891979 Ki 0.22 nM
CC(=O)c1ccc(C(=O)Nc2cccc(C(=O)c3ccc4c(/C=C/c5ccccn5)n[nH]c4c3)c2)s1 CHEMBL3899200 Ki 0.22 nM
CC(C)(C)c1ccc(C(=O)Nc2cccc(C(=O)c3ccc4c(/C=C/c5ccccn5)n[nH]c4c3)c2)cc1 CHEMBL3922242 Ki 0.23 nM
O=C(Nc1cc(Nc2ccc3c(/C=C/c4ccccc4)n[nH]c3c2)ccc1F)c1ccccc1 CHEMBL3919150 Ki 0.25 nM
N#Cc1c(-c2ccc(Cl)cc2)cc(-c2ccc3ccccc3c2)nc1NN CHEMBL5427972 IC50 0.25 nM
Cc1cc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(N)c34)cc2)ccc1F CHEMBL273187 pKi 0.2512 nM
Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1 CHEMBL2409778 IC50 0.26 nM
O=C(Nc1cccc(C(=O)c2ccc3c(/C=C/c4ccccn4)n[nH]c3c2)c1)c1ccncc1 CHEMBL3956618 Ki 0.26 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4ccc(C)cc4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5410264 IC50 0.26 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4cnn(C5CCCC5)c4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5421802 IC50 0.26 nM
CCn1nc(C)cc1C(=O)Nc1cccc(Oc2ccc3c(/C=C/c4c[nH]c(C)n4)n[nH]c3c2)c1 CHEMBL3965764 Ki 0.27 nM
CCCCCCCCC(O)Cn1cc2c(N)ncnc2n1 CHEMBL190239 Ki 0.28 nM
O=C(Nc1ccccc1)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL3963347 Ki 0.28 nM
O=C(Nc1cccc(Oc2ccc3c(/C=C/c4ccccn4)n[nH]c3c2)c1)c1ccccc1 CHEMBL3921873 Ki 0.29 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5nccs5)cccc4c3)c2cc1OC CHEMBL272691 IC50 0.3 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5cc(Cl)cc(Cl)c5)cccc4c3)c2cc1OC CHEMBL269916 IC50 0.3 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5cccc(Cl)c5)cccc4c3)c2cc1OC CHEMBL270092 IC50 0.3 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5ccc(Cl)cc5)cccc4c3F)c2cc1OC CHEMBL429585 IC50 0.3 nM
O=C(c1ccncc1)N1CCc2nc(-c3cc4cc(F)ccc4[nH]c3=O)[nH]c2C1 CHEMBL2016903 IC50 0.3 nM
COc1cc(-c2ccc3c(/C=C/c4ccc(OC)c(OC)c4)n[nH]c3c2)ccc1O CHEMBL3923888 Ki 0.3 nM
COC(=O)CN(CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1)CC(=O)OC CHEMBL3918564 IC50 0.3 nM
Nc1ncc2ccc(-c3ccc(NC(=S)Nc4ccc(OC(F)(F)F)cc4Br)cc3)cc2n1 CHEMBL4060841 IC50 0.31 nM
Nc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL403402 pKi 0.3162 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4ccnn4C4CCCC4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5425976 IC50 0.32 nM
O=C(c1cccc(NC(=O)c2ccno2)c1)c1ccc2c(/C=C/c3ccccc3)n[nH]c2c1 CHEMBL3922509 Ki 0.33 nM
CNC(=O)c1csc2cc(Oc3ccnc4cc(C5=NCCN5C)sc34)ccc12 CHEMBL1289925 IC50 0.34 nM
Cc1cccc(C(=O)Nc2cccc(N(C)c3ccc4c(/C=C/c5ccc6c(c5)OCO6)n[nH]c4c3)c2)c1 CHEMBL3951790 Ki 0.34 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4ccc5occc5c4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5403747 IC50 0.34 nM
N#Cc1c(-c2ccc([N+](=O)[O-])cc2)cc(-c2ccc3ccccc3c2)nc1NN CHEMBL5402284 IC50 0.34 nM
O=C(Nc1cccc(C(=O)c2ccc3c(-c4nc5ccccc5[nH]4)n[nH]c3c2)c1)c1ccccc1 CHEMBL3954085 Ki 0.35 nM
O=C(Nc1ccc(-c2cccnc2)cc1)Nc1cc(Br)cc(C(F)(F)F)c1 CHEMBL3586049 IC50 0.36 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4ccc(-c5ccccc5)cc4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5400860 IC50 0.36 nM
COc1cc2nccc(Oc3ccc4c(C(=O)NC5CC5)cccc4c3)c2cc1C(N)=O CHEMBL272250 IC50 0.37 nM
O=C(Nc1cccc(Oc2ccc3c(/C=C/c4ccccc4)n[nH]c3c2)c1)c1cccc2[nH]ccc12 CHEMBL3925024 Ki 0.37 nM
CCn1nc(C)cc1C(=O)Nc1cccc(Oc2ccc3c(/C=C/c4ccccc4)n[nH]c3c2)c1 CHEMBL3925826 Ki 0.37 nM
CCn1nc(C)cc1C(=O)Nc1cc(Nc2ccc3c(/C=C/c4ccccn4)n[nH]c3c2)c(F)cc1C CHEMBL3982880 Ki 0.37 nM
COc1cc2nccc(Oc3ccc4c(C(=O)NC5CC5)cccc4c3)c2cc1C(C)=O CHEMBL1241686 pIC50 0.3715 nM
Cc1cnc(C(=O)Nc2cccc(N(C)c3ccc4c(/C=C/c5ccccc5)n[nH]c4c3)c2)s1 CHEMBL3896103 Ki 0.39 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c2cc1OC CHEMBL180331 IC50 0.4 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(F)ccc4F)cc3)c2cc1OC CHEMBL179522 IC50 0.4 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(Cl)c3)c2cc1OC CHEMBL279351 IC50 0.4 nM
COCCOc1cc2ncnc(NC3=CC(=O)C(OC(CF)CF)=C(Cl)C3=O)c2cc1OC CHEMBL2113171 IC50 0.4 nM
CC1=CC[C@@H]2[C@@H](C1)c1c(O)cc(C(C)(C)CCCCBr)cc1OC2(C)C CHEMBL199561 Ki 0.4 nM
O=C(Nc1cccc(C(F)(F)F)c1)n1ccc2cc(Oc3ncnc4c3CNC4)ccc21 CHEMBL3747481 IC50 0.4 nM
O=C(O)Cc1cccc(Nc2cc(Oc3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)ncn2)c1 CHEMBL4875220 IC50 0.4 nM
COc1ccc(/C=C/C(=N/Nc2nncc3ccccc23)c2ccc(Cl)cc2)cc1 CHEMBL3897723 IC50 0.41 nM
O=C(Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c(F)c1)c1cccn(-c2ccccc2)c1=O CHEMBL3093583 IC50 0.42 nM
C(=C/c1ccccc1)\C(=N\Nc1nncc2ccccc12)c1ccccc1 CHEMBL3903713 IC50 0.42 nM
Cc1ccc(NC(=O)Cn2cc(-c3ccc4c(NC(=O)c5ccc(N6CCNCC6)cc5)n[nH]c4c3)cn2)cc1C(F)(F)F CHEMBL5275552 IC50 0.42 nM
N#Cc1ccc(Nc2nncc3ccccc23)cc1 CHEMBL3915508 IC50 0.43 nM
CN(c1cccc(NC(=O)c2cccc(C(F)(F)F)c2)c1)c1ccc2c(/C=C/c3ccc4c(c3)OCO4)n[nH]c2c1 CHEMBL3906996 Ki 0.43 nM
COc1ccc2c(Oc3ccc4c(C(=O)NC5CC5)cccc4c3)ccnc2c1 CHEMBL270342 pIC50 0.4467 nM
CNc1cc2c(cn1)cc(-c1ccc(F)c(NC(=O)Nc3cc(C(C)(C)C)no3)c1)c(=O)n2[C@H]1CCOC1 CHEMBL3577114 IC50 0.46 nM
CCCCCCCCCCCn1cc2c(N)ncnc2n1 CHEMBL190495 Ki 0.47 nM
Cc1ccc(Oc2ccc3nc(NC(=O)C4CC4)nn3c2)cc1NC(=O)c1scc(C)c1Cl CHEMBL2409785 IC50 0.48 nM
CC(=O)Nc1cccc(Oc2ccc3c(/C=C/c4ccccc4)n[nH]c3c2)c1 CHEMBL3944307 Ki 0.48 nM
COc1cc(O)c2c(c1)/C=C/C[C@@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O CHEMBL1668411 IC50 0.49 nM
O=C(Nc1cccc(C(=O)c2ccc3c(/C=C/c4ccccc4)n[nH]c3c2)c1)c1ccccc1 CHEMBL3941907 Ki 0.49 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(C)cc4)cc3)c2cc1OC CHEMBL362634 IC50 0.5 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4F)cc3)c2cc1OC CHEMBL179227 IC50 0.5 nM
COc1cc2nccc(Oc3ccc4oc(Nc5ccc(Cl)c(CN6CCN(C)CC6)c5)nc4c3)c2cc1OC CHEMBL230107 Ki 0.5 nM
COc1cc2nccc(Oc3ccc4oc(Nc5ccc(Cl)c(OC[C@@H]6CCCN6C)c5)nc4c3)c2cc1OC CHEMBL389963 Ki 0.5 nM
COc1cc2ncnc(Oc3ccc4oc(Nc5ccc(Cl)c(OC[C@@H]6CCCN6C)c5)nc4c3)c2cc1OC CHEMBL230003 Ki 0.5 nM
COc1cc2nccc(Oc3ccc4c(c3)OCCN4C(=O)Nc3ccc(Cl)cc3)c2cc1OC CHEMBL270548 IC50 0.5 nM
COc1cc2nccc(Oc3ccc4c(c3)OCCN4C(=O)Nc3ccc(C)cc3)c2cc1C(N)=O CHEMBL270954 IC50 0.5 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5ccc(C(F)(F)F)cc5)cccc4c3)c2cc1OC CHEMBL270985 IC50 0.5 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5cccc(C(F)(F)F)c5)cccc4c3)c2cc1OC CHEMBL271563 IC50 0.5 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5ccc(C)cc5)cccc4c3)c2cc1OC CHEMBL411091 IC50 0.5 nM
COc1ccc(NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]cc(C(=O)O)c2C)cc1 CHEMBL1173411 IC50 0.5 nM
O=C(Cc1ccncc1)N1CCc2nc(-c3cc4cc(Cl)ccc4[nH]c3=O)[nH]c2C1 CHEMBL2016927 IC50 0.5 nM
Nc1n[nH]c2cccc(-c3cccc(NC(=O)Nc4cccc(Cl)c4)c3)c12 CHEMBL3633294 IC50 0.5 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5cccnc5)cccc4c3)n2)c1 CHEMBL3739732 IC50 0.5 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5ccccc5)cccc4c3)n2)c1 CHEMBL3740721 IC50 0.5 nM
CC1(c2cc(NC(=O)n3ccc4cc(Oc5ncnc6c5CNC6)ccc43)n[nH]2)CC1 CHEMBL3746941 IC50 0.5 nM
COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1 CHEMBL491473 IC50 0.5 nM
COc1cc2nccc(Oc3ccc4c(c3)OCCN4C(=O)Nc3ccc(C)cc3)c2cc1C(C)=O CHEMBL1242575 pIC50 0.5012 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4ccc(OC(F)(F)F)cc4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5407330 IC50 0.51 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5438830 IC50 0.51 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4cnn(C(C)C)c4)c(F)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5421149 IC50 0.51 nM
COc1ccc(-c2ccc(Cn3cc(-c4ccc(NC(=O)C5CC5)cc4)nn3)cc2)cn1 CHEMBL4473253 IC50 0.52 nM
Cc1cccc(-c2cn(Cc3ccc(-c4cn[nH]c4)cc3)nn2)c1 CHEMBL4472113 IC50 0.53 nM
Cc1ccc(C(=O)Nc2ccc(Oc3ccc4nc(NC(=O)C5CC5)cn4c3)c(F)c2)c(=O)n1-c1ccccc1 CHEMBL3093579 IC50 0.54 nM
CCOC(=O)c1ccc(Nc2nncc3ccccc23)cc1 CHEMBL3906533 IC50 0.54 nM
O=C(c1cccc(NC(=O)c2cc(Cl)ccn2)c1)c1ccc2c(/C=C/c3ccccc3)n[nH]c2c1 CHEMBL3945318 Ki 0.54 nM
Clc1ccc(/C=C/C(=N/Nc2nncc3ccccc23)c2ccccc2)cc1 CHEMBL3900264 IC50 0.55 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4cccc(F)c4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5412761 IC50 0.55 nM
Cc1ccc(-c2cn(Cc3ccc(-c4cnn(C)c4)cc3)nn2)cc1 CHEMBL4543212 IC50 0.57 nM
COc1ccc(NC(=O)Nc2ccc(Oc3ncnc4cc(OCCCN5CCCC5)c(OC)cc34)cc2Cl)c(OC)c1 CHEMBL5411025 IC50 0.59 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cncc4[nH]nc(N)c34)cc2)c1 CHEMBL272938 IC50 0.6 nM
COc1cc2nccc(Oc3ccc4c(c3)OCCN4C(=O)Nc3ccc(Cl)cc3)c2cc1C(N)=O CHEMBL409867 IC50 0.6 nM
COc1cc2nccc(Oc3ccc4c(C(=O)NC5CC5)cccc4c3)c2cc1OC CHEMBL272198 IC50 0.6 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5cc(C)on5)cccc4c3)c2cc1OC CHEMBL259461 IC50 0.6 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5cccc(F)c5)cccc4c3)c2cc1OC CHEMBL412291 IC50 0.6 nM
Cc1n[nH]c2cc(N(C)c3ccnc(Nc4cccc(S(N)(=O)=O)c4)n3)ccc12 CHEMBL477611 IC50 0.6 nM
COc1cc2ncnc(Nc3ccc(C)c(O)c3)c2cc1OC CHEMBL478442 IC50 0.6 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc4c(C(=O)NC5CC5)cccc4c3)n2)c1 CHEMBL3741966 IC50 0.6 nM
CCONC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL3963146 Ki 0.6 nM
COc1cc2nccc(Oc3ccc4c(c3)OCCN4C(=O)Nc3ccc(Cl)cc3)c2cc1C(C)=O CHEMBL1242478 pIC50 0.6026 nM
C=C(c1cccc(NC(=O)c2ccccc2)c1)c1ccc2c(/C=C/c3ccccc3)n[nH]c2c1 CHEMBL3915043 Ki 0.63 nM
Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)ccnc21 CHEMBL1985888 pKi 0.631 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccc[nH]2)C(=O)N3)c1)Cc1ccccc1 CHEMBL1980407 pKi 0.631 nM
CCN(CC)CCCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL1999414 pKi 0.631 nM
C=C(c1cccc(NC(=O)OCc2ccccc2)c1)c1ccc2c(/C=C/c3ccccc3)n[nH]c2c1 CHEMBL3947822 Ki 0.64 nM
O=C(Nc1cccc(Oc2ccc3c(/C=C/c4ccccc4)n[nH]c3c2)c1)c1ccccc1 CHEMBL3961315 Ki 0.65 nM
Cc1ccc2cc(NC(=O)c3ccccc3Sc3ccc4c(/C=C/c5ccccn5)n[nH]c4c3)ccc2n1 CHEMBL3938361 Ki 0.66 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5393865 IC50 0.66 nM
Fc1ccc(Nc2nncc3ccccc23)cc1 CHEMBL3979610 IC50 0.67 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4ccc5c(ccn5C)c4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5410108 IC50 0.67 nM
O=C(O)c1ccc(Nc2nncc3ccccc23)cc1 CHEMBL3937949 IC50 0.68 nM
O=C(c1cccc(NC(=O)c2cccc(Cl)n2)c1)c1ccc2c(/C=C/c3ccccc3)n[nH]c2c1 CHEMBL3907378 Ki 0.68 nM
Clc1ccc(C(/C=C/c2ccccc2)=N\Nc2nncc3ccccc23)cc1 CHEMBL3966129 IC50 0.69 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(F)c4F)cc3)c2cc1OC CHEMBL179698 IC50 0.7 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2cc1OC CHEMBL360526 IC50 0.7 nM
Cc1cc(NC(=O)Nc2ccc(-c3cncc4[nH]nc(N)c34)cc2)ccc1F CHEMBL404669 IC50 0.7 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5ccc(C(C)(C)C)cc5)cccc4c3)c2cc1OC CHEMBL407715 IC50 0.7 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cnc4c(-c5cnn(C)c5)ccn4c3N)cc2)c1 CHEMBL453057 IC50 0.7 nM
O=C(Cc1ccccn1)N1CCc2nc(-c3cc4cc(F)ccc4[nH]c3=O)[nH]c2C1 CHEMBL2016924 IC50 0.7 nM
Cc1ccc(C(/C=C/c2ccc(F)cc2)=N\Nc2nncc3ccccc23)cc1 CHEMBL3983586 IC50 0.7 nM
CC(=O)N1Cc2ncnc(Oc3ccc4c(ccn4C(=O)Nc4cc(C5(C(F)(F)F)CC5)on4)c3)c2C[C@@H]1C CHEMBL4076909 IC50 0.7 nM
COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(N)=O CHEMBL1289601 IC50 0.7 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4ccccc4F)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5396911 IC50 0.7 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5394759 IC50 0.71 nM
Cc1cnc(C(=O)Nc2cccc(C(=O)c3ccc4c(/C=C/c5ccccc5)n[nH]c4c3)c2)s1 CHEMBL3948411 Ki 0.72 nM
Cc1ccc(NC(=O)Cn2cc(-c3ccc4c(NC(=O)c5cnn(C)c5)n[nH]c4c3)cn2)cc1C(F)(F)F CHEMBL4878552 IC50 0.73 nM
O=C(Nc1cccc(Oc2ccc3c(/C=C/c4ccc(Cl)cc4)n[nH]c3c2)c1)c1ccccc1 CHEMBL3892583 Ki 0.74 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4ccc(Br)cc4F)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5405000 IC50 0.74 nM
Cc1cc(C(=O)Nc2cccc(C(=O)c3ccc4c(/C=C/c5ccccn5)n[nH]c4c3)c2)on1 CHEMBL3918357 Ki 0.75 nM
COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cnn(C(C)C)c4)c4ccccc34)c2cc1OC CHEMBL4099365 IC50 0.75 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4cnn(C(C)C)c4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5412144 IC50 0.76 nM
Cc1cc(C)nc(NS(=O)(=O)c2ccc(Nc3nncc4ccccc34)cc2)n1 CHEMBL3950630 IC50 0.77 nM
Nc1n[nH]c2cccc(-c3cccc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)c3)c12 CHEMBL3633304 IC50 0.79 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5ccccn5)cccc4c3)c2cc1OC CHEMBL269915 pIC50 0.7943 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5cccnc5)cccc4c3)c2cc1OC CHEMBL406388 pIC50 0.7943 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5cc(C(C)(C)C)on5)cccc4c3)c2cc1OC CHEMBL408478 pIC50 0.7943 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)c(F)c3)c12 CHEMBL1980904 pKi 0.7943 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 IC50 0.8 nM
COC(=O)CNCCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1 CHEMBL3896004 IC50 0.8 nM
OC[C@H](Nc1cnc(-c2cc(Cl)ccc2O)c(-c2ccc3cnccc3c2)c1)c1ccccc1 CHEMBL4067871 IC50 0.8 nM
O=C(Nc1cccc(Oc2ccc3c(/C=C/c4ccco4)n[nH]c3c2)c1)c1ccccc1 CHEMBL3907574 Ki 0.83 nM
O=C(NNc1ccccn1)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL3931953 Ki 0.83 nM
CC1=[N+](c2ccccc2)C(=O)C(C(=O)Nc2ccc(Oc3ccc4nc(NC(=O)C5CC5)cn4c3)c(F)c2)C=C1 CHEMBL3765306 IC50 0.86 nM
Fc1ccc(/C=C/C(=N/Nc2nncc3ccccc23)c2ccccc2)cc1 CHEMBL3963403 IC50 0.88 nM
COc1cc2nccc(Oc3ccc4c(C(N)=O)cccc4c3)c2cc1OC CHEMBL271984 pIC50 0.8913 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC CHEMBL178455 IC50 0.9 nM
COCCOc1cc2ncnc(NC3=CC(=O)C(Oc4cccc(F)c4)=CC3=O)c2cc1OC CHEMBL2113187 IC50 0.9 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4ccccc4)ccc32)c(C)c1CC(=O)O CHEMBL1172422 IC50 0.9 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(C)c3)c2cc1OC CHEMBL1242557 IC50 0.9 nM
Nc1ncnc2scc(-c3ccc4c(C(=O)Nc5ccccc5)cccc4c3)c12 CHEMBL3288526 IC50 0.9 nM
COc1ccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5ccccc5)cccc4c3)n2)cc1OC CHEMBL3740856 IC50 0.9 nM
COc1cc(Nc2nccc(Oc3ccc4c(C(=O)Nc5ccccc5)cccc4c3)n2)cc(OC)c1OC CHEMBL3741641 IC50 0.9 nM
C[C@@H]1Cc2c(ncnc2Oc2ccc3c(ccn3C(=O)Nc3cc(C4(C)CC4)[nH]n3)c2)CN1 CHEMBL3746273 IC50 0.9 nM
C[C@H]1Cc2c(ncnc2Oc2ccc3c(ccn3C(=O)Nc3cc(C4(C)CC4)[nH]n3)c2)CN1 CHEMBL3746776 IC50 0.9 nM
Cc1cccc(C(=O)Nc2cccc(Oc3ccc4c(/C=C/c5ccccc5)n[nH]c4c3)c2)c1 CHEMBL3942288 Ki 0.9 nM
COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cc(C)on4)c4ccccc34)c2cc1OC CHEMBL4073263 IC50 0.92 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4cnn(C(C)C)c4)c(Cl)c3)ncnc2cc1OCCN1CCCC1 CHEMBL5414216 IC50 0.93 nM
Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c2)nn1C CHEMBL2348998 IC50 0.96 nM
COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OC[C@@H]1CCCN(C)C1 CHEMBL1907764 IC50 1.0 nM
CN(c1ccc(NC(=O)Nc2cc(C(F)(F)F)ccc2F)cc1)c1ccnc(Nc2cccc(S(N)(=O)=O)c2)n1 CHEMBL189354 IC50 1.0 nM
CN(c1ccc(NC(=O)Nc2cc(C(F)(F)F)ccc2F)cc1)c1ccnc(Nc2ccc(S(N)(=O)=O)cc2)n1 CHEMBL185716 IC50 1.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)c1 CHEMBL196363 IC50 1.0 nM
COCCOc1cc2ncnc(NC3=CC(=O)C(OC)=C(Cl)C3=O)c2cc1OC CHEMBL2113172 IC50 1.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3nsc4ncnc(N)c34)cc2)c1 CHEMBL376951 IC50 1.0 nM
CNc1ncc2cc(-c3cc(C(=O)Nc4cccc(C(F)(F)F)c4)ccc3C)ccc2n1 CHEMBL212964 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1 CHEMBL215943 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1C#Cc1cnc2ccccc2c1 CHEMBL219584 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1C#Cc1ccc(N)nc1 CHEMBL220874 IC50 1.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cncnc5)cnc(N)c34)cc2)c1 CHEMBL231127 IC50 1.0 nM
CN1CCC[C@@H]1COc1cc(Nc2nc3cc(Oc4ccnc5ccccc45)ccc3[nH]2)ccc1C(F)(F)F CHEMBL231370 Ki 1.0 nM
CCCn1c2ccc(/C(C)=N/OC)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL258014 IC50 1.0 nM
C/C(=N\O)c1ccc2[nH]c3c4c(c5c(c3c2c1)CNC5=O)-c1cn(C)nc1CC4 CHEMBL404322 IC50 1.0 nM
CO/N=C(\C)c1ccc2[nH]c3c4c(c5c(c3c2c1)CNC5=O)-c1cn(C)nc1CC4 CHEMBL257789 IC50 1.0 nM
Nc1n[nH]c2cncc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL256246 IC50 1.0 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(N)c34)cc2)c1 CHEMBL255744 IC50 1.0 nM
Nc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12 CHEMBL255746 IC50 1.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cncc4[nH]nc(N)c34)cc2)c1 CHEMBL271441 IC50 1.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(N)c34)cc2)c1 CHEMBL255743 IC50 1.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(N)c34)cc2)c1 CHEMBL257479 IC50 1.0 nM
COc1cc2nccc(Oc3ccc4c(c3)OCCN4C(=O)Nc3ccccc3)c2cc1OC CHEMBL429430 IC50 1.0 nM
COc1cc2nccc(Oc3ccc4c(c3)OCCN4C(=O)N[C@@H](C)c3ccccc3)c2cc1OC CHEMBL270306 IC50 1.0 nM
CCNC(=O)N1CCOc2cc(Oc3ccnc4cc(OC)c(OC)cc34)ccc21 CHEMBL272875 IC50 1.0 nM
COc1cc2nccc(Oc3ccc4c(c3)OCCN4C(=O)Nc3cccc(Cl)c3)c2cc1OC CHEMBL272878 IC50 1.0 nM
COc1cc2nccc(Oc3ccc4c(c3)OCCN4C(=O)Nc3cccc(C)c3)c2cc1OC CHEMBL270057 IC50 1.0 nM
COc1cc2nccc(Oc3ccc4c(c3)OCCN4C(=O)Nc3ccccc3C)c2cc1OC CHEMBL270058 IC50 1.0 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5cc(C)no5)cccc4c3)c2cc1OC CHEMBL270978 IC50 1.0 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5ccc(Cl)c(C(F)(F)F)c5)cccc4c3)c2cc1OC CHEMBL269914 IC50 1.0 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5ccc(F)cc5)cccc4c3)c2cc1OC CHEMBL410841 IC50 1.0 nM
COc1ccc2c(Oc3ccc4c(C(=O)Nc5ccc(Cl)cc5)cccc4c3)ccnc2c1 CHEMBL273062 IC50 1.0 nM
CCn1c2ccc(C(=O)c3cccs3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL402531 IC50 1.0 nM
CCCNC(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1Cl CHEMBL406381 IC50 1.0 nM
COc1ccc(NC(=O)Nc2nn(C)c3cc(Oc4ccnc5cc(OC)c(OC)cc45)ccc23)cc1 CHEMBL452569 IC50 1.0 nM
COc1ccccc1Nc1cccc2cc(Oc3ccnc4cc(OC)c(OC)cc34)ccc12 CHEMBL459896 IC50 1.0 nM
COc1cc2nccc(Oc3ccc4c(NC(=O)c5cccc(C(F)(F)F)c5)nn(C)c4c3)c2cc1OC CHEMBL462168 IC50 1.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cnc4c(-c5cnn(C)c5)cnn4c3N)cc2)c1 CHEMBL508928 IC50 1.0 nM
COc1cc2nccc(CN3CCc4c(cccc4C(=O)Nc4ccc(C(C)(C)C)cc4)C3)c2cc1OC CHEMBL493877 IC50 1.0 nM
COc1cc2nccc(CN3CCc4c(cccc4C(=O)Nc4ccc(F)c(C(F)(F)F)c4)C3)c2cc1OC CHEMBL493876 IC50 1.0 nM
COc1cc2nccc(CN3CCc4c(cccc4C(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)C3)c2cc1OC CHEMBL493253 IC50 1.0 nM
COc1cc2nccc(CN3CCc4c(cccc4C(=O)Nc4cccc(C(F)(F)F)c4)C3)c2cc1OC CHEMBL493047 IC50 1.0 nM
CCn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)C5(C(=O)Nc6ccccc6)CC5)cc4F)c3s2)c1 CHEMBL565807 IC50 1.0 nM
Oc1ccc(-c2cnn3cc(-c4ccc(OCCN5CCOCC5)cc4)cnc23)cc1O CHEMBL1271641 IC50 1.0 nM
Cc1c(/C=C2\C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)N(C[C@H](O)CN1CCOCC1)CC2 CHEMBL1276980 IC50 1.0 nM
Cc1c(/C=C2\C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)N(CCN1CCOCC1)CCC2 CHEMBL1277071 IC50 1.0 nM
COc1ccc(Nc2ncc3c(n2)-c2ccc(Cl)cc2NC(=S)C3)cc1CCCN(C)C CHEMBL1945502 IC50 1.0 nM
COc1cccc(OC)c1CNc1nc(NC2CCCCC2)nc2ccc(Cl)cc12 CHEMBL1996646 pKi 1.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CCO)c5)cnc(N)c34)cc2F)c1 CHEMBL1986851 pKi 1.0 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 pKi 1.0 nM
COc1ccc(-c2ccc(NC(=O)Nc3ccc(OC(F)(F)F)cc3)cc2)c2c(N)noc12 CHEMBL1973178 pKi 1.0 nM
O=C(c1cccnc1)N1CCc2nc(-c3cc4cc(F)ccc4[nH]c3=O)[nH]c2C1 CHEMBL2016900 IC50 1.0 nM
CS(=O)(=O)CCn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL2022853 IC50 1.0 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL2023221 IC50 1.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cc[nH]c5)cnc(N)c34)cc2)c1 CHEMBL2021941 IC50 1.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cnn(CC(=O)O)c3)ncc2Cl)[C@H]2C=C[C@@H]1C2 CHEMBL2071271 IC50 1.0 nM
O=C(Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c1)c1cccc(F)c1 CHEMBL2349006 IC50 1.0 nM
Cc1[nH]c2c(c1C(=O)NCCCN1CCOCC1)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430248 IC50 1.0 nM
CC(C)(C)c1cc(NC(=O)n2ccc3cc(Oc4ncnc5c4CCNC5)ccc32)n[nH]1 CHEMBL3747084 IC50 1.0 nM
N#CC1(c2ccc(NC(=O)c3cccnc3NCc3ccncc3)cc2)CCCC1 CHEMBL3545414 IC50 1.0 nM
COCCNCc1ccc(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccc(F)cc5)cc4F)c3s2)nc1 CHEMBL3989914 IC50 1.0 nM
C[C@H]1Cc2c(ncnc2Oc2ccc3c(ccn3C(=O)Nc3cc(C4(C(F)(F)F)CC4)on3)c2)CN1 CHEMBL3808921 IC50 1.0 nM
CC(C)(C)c1cc(NC(=O)n2ccc3cc(Oc4ncnc5c4CNC5)ccc32)n[nH]1 CHEMBL3808622 IC50 1.0 nM
Cc1ccoc1C(=O)Nc1cccc(C#Cc2cc(C(=O)N=S(C)(C)=O)cnc2N)c1 CHEMBL3978649 IC50 1.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3occc3C)c2)c1 CHEMBL3974963 IC50 1.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3cccc(C)c3)c2)c1 CHEMBL3970053 IC50 1.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3cc(C(F)(F)F)ccc3F)c2)c1 CHEMBL3918345 IC50 1.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3cccc(OC)c3)c2)c1 CHEMBL3933295 IC50 1.0 nM
COC(=O)CCCC[S@](C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3occc3C)c2)c1 CHEMBL3906392 IC50 1.0 nM
COC(=O)CCCC[S@@](C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3occc3C)c2)c1 CHEMBL4112857 IC50 1.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(C(=O)Nc3cc(C(C)(C)C)on3)c2)c1 CHEMBL3985051 IC50 1.0 nM
Cc1ccoc1C(=O)Nc1cccc(C#Cc2cncc(C(=O)N=S(C)(=O)CCCO)c2)c1 CHEMBL3897137 IC50 1.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(C(=O)NCCCN5CCOC(CO)C5)sc34)cc2F)c1 CHEMBL3964131 IC50 1.0 nM
CCOC(=O)CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1 CHEMBL3919480 IC50 1.0 nM
O=C(Nc1ccc(Oc2ncnc3cc(OCCCN4CCOCC4)c4c(c23)OCCO4)cc1F)Nc1cc(C(F)(F)F)ccc1F CHEMBL4455006 IC50 1.0 nM
Cc1ccc(-c2n[nH]c3cc(SCCC(=O)Nc4ccc(CN5CCN(C)CC5)c(C(F)(F)F)c4)ccc23)cn1 CHEMBL4556829 GI50 1.0 nM
CN1CCN(Cc2ccc(NC(=O)CCSc3ccc4c(-c5ccncc5)n[nH]c4c3)cc2C(F)(F)F)CC1 CHEMBL4517419 GI50 1.0 nM
CN1CCN(Cc2ccc(C(=O)NCCCSc3ccc4c(/C=C/c5ccccn5)n[nH]c4c3)cc2C(F)(F)F)CC1 CHEMBL4591810 GI50 1.0 nM
CCc1cccc(NC(=O)c2cccc3cc(Oc4cc(N)ncn4)ccc23)c1 CHEMBL5283863 IC50 1.0 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1171837 AC50 1.0 nM
Nc1ncc2ccc(-c3ccc(NC(=S)Nc4cc(Br)cc(C(F)(F)F)c4)cc3)cc2n1 CHEMBL4069517 IC50 1.05 nM
COc1cc(-c2cc(NC(=O)Nc3ccc(OCCCN4CCOCC4)cc3)cc(OC)c2OC)ccc1/C(C)=N/O CHEMBL3220323 IC50 1.08 nM
COc1ccc(NC(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)cc1 CHEMBL179593 IC50 1.1 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc([N+](=O)[O-])c4)cc3)c2cc1OC CHEMBL179360 IC50 1.1 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)c(F)c4)cc3)c2cc1OC CHEMBL179719 IC50 1.1 nM
COC(=O)Nc1nc2cc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)cc3)ccc2[nH]1 CHEMBL243908 IC50 1.1 nM
O=C(Nc1cccc(Oc2ccc3nc(NC(=O)C4CCOCC4)cn3n2)c1)c1cccc(C(F)(F)F)c1 CHEMBL2348989 IC50 1.1 nM
Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)ccc2F)n(C)n1 CHEMBL2348991 IC50 1.1 nM
CC(=O)Nc1cn2nc(Oc3cccc(NC(=O)c4cccc(F)c4)c3)ccc2n1 CHEMBL2349005 IC50 1.1 nM
Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4c3)c2)n(C)n1 CHEMBL2409779 IC50 1.1 nM
Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)c2)n(C)n1 CHEMBL2409775 IC50 1.1 nM
Cc1[nH]c2c(c1C(=O)N1CCOCC1)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430251 IC50 1.1 nM
Cc1[nH]c2c(c1C(=O)NCCO)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430262 IC50 1.1 nM
O=C(Nc1cccc(C(=O)c2ccc3c(/C=N/n4cnnc4)n[nH]c3c2)c1)c1ccccc1 CHEMBL3899567 Ki 1.1 nM
CN(C)c1cccc(C(=O)Nc2cccc(N(C)c3ccc4c(/C=C/c5ccc6c(c5)OCO6)n[nH]c4c3)c2)c1 CHEMBL3904228 Ki 1.1 nM
COc1cc(-c2ccc3c(/C=C/c4ccc(NC(=O)CN)cc4)n[nH]c3c2)ccc1O CHEMBL3919791 Ki 1.1 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4cccc5c4oc4ccccc45)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5426431 IC50 1.13 nM
COc1cc2c(Oc3ccc(NC(=O)NCc4ccccc4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5408069 IC50 1.15 nM
O=C(Nc1cccc(-c2cncc3ccccc23)c1)c1ccccc1NCc1ccncc1 CHEMBL347537 IC50 1.16 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c2cc1OC CHEMBL426602 IC50 1.2 nM
Nc1n[nH]c2cncc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12 CHEMBL404342 IC50 1.2 nM
COc1ccc2c(Oc3ccc4c(C(N)=O)cccc4c3)ccnc2c1 CHEMBL272252 IC50 1.2 nM
O=C(Nc1cccc(C(F)(F)F)c1)c1ccccc1NCc1ccncc1 CHEMBL153843 IC50 1.2 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 1.2 nM
CN(c1ccc(F)c(NC(=O)c2cccc(OC(C)(C)C#N)c2Cl)c1)c1ccc2nc(NC(=O)C3CC3)sc2n1 CHEMBL2204532 IC50 1.2 nM
Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c2)n(-c2ccccc2)n1 CHEMBL2348995 IC50 1.2 nM
Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)sc4n3)ccc2C)n(C)n1 CHEMBL2409782 IC50 1.2 nM
Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4c3)ccc2C)n(C)n1 CHEMBL2409780 IC50 1.2 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5cccc(F)c5)cccc4c3)n2)c1 CHEMBL3740487 IC50 1.2 nM
CCCCN1C(=O)CS/C1=N/Nc1nncc2ccccc12 CHEMBL3921710 IC50 1.2 nM
CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(N5CCN(CCO)CC5)cc4)c3)ccc12 CHEMBL4278642 IC50 1.2 nM
COc1cc2nccc(Oc3ccc4c(C(N)=O)cccc4c3)c2cc1C(C)=O CHEMBL1241685 pIC50 1.202 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(O)CO)c5)cnc(N)c34)cc2)cc1 CHEMBL1965170 pKi 1.259 nM
CCN(CC)CCCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)csc12 CHEMBL1996649 pKi 1.259 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3coc4c(C#CCN5CCOCC5)cnc(N)c34)cc2)c1 CHEMBL1983640 pKi 1.259 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4ccc(OC(F)F)cc4)cc3)c12 CHEMBL1972220 pKi 1.259 nM
Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4ccc(F)c(C(F)(F)F)c4)cc3)ccnc21 CHEMBL1966836 pKi 1.259 nM
NC(=O)c1c(OCc2c(F)cc(Br)cc2F)nsc1NC(=O)NCCCCN1CCCC1 CHEMBL253969 IC50 1.27 nM
CCN(CC)CCOc1ccc(NC(=O)Nc2cc(OC)c(OC)c(-c3ccc(/C(C)=N/O)c(OC)c3)c2)cc1 CHEMBL3220318 IC50 1.28 nM
CCCNC(=O)c1cccc2cc(Oc3ccnc4cc(OC)c(OC)cc34)ccc12 CHEMBL409103 pIC50 1.288 nM
CCNC(=O)c1cccc2cc(Oc3ccnc4cc(OC)c(OC)cc34)ccc12 CHEMBL269871 pIC50 1.288 nM
COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cccc(SC(F)(F)F)c4)cc3)cc2[nH]1 CHEMBL244095 IC50 1.3 nM
COc1cc2nccc(Oc3ccc4c(C(N)=O)cccc4c3)c2cc1C(N)=O CHEMBL260532 IC50 1.3 nM
COc1cc2ncnc(Oc3ccc4c(C(N)=O)cccc4c3)c2cc1OC CHEMBL270556 IC50 1.3 nM
COc1cc2nccc(Oc3ccc4c(C(=O)NC5CCC5)cccc4c3)c2cc1OC CHEMBL259252 IC50 1.3 nM
CC1=CC[C@@H]2[C@@H](C1)c1c(O)cc(C(C)(C)CCCCCCBr)cc1OC2(C)C CHEMBL1683648 Ki 1.3 nM
O=C(c1ccc(CN2CCCCC2)cc1)N1CCc2nc(-c3cc4ccccc4[nH]c3=O)[nH]c2C1 CHEMBL2016904 IC50 1.3 nM
O=C(Cc1ccccn1)N1CCc2nc(-c3cc4ccccc4[nH]c3=O)[nH]c2C1 CHEMBL2016923 IC50 1.3 nM
Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)ccc2Cl)n(C)n1 CHEMBL2348990 IC50 1.3 nM
Cn1nncc1C(=O)Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c1 CHEMBL2348999 IC50 1.3 nM
O=C(Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c1)c1ccno1 CHEMBL2349001 IC50 1.3 nM
O=C(Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c1)c1ccncc1 CHEMBL2349002 IC50 1.3 nM
Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)sc4n3)c2)n(C)n1 CHEMBL2409781 IC50 1.3 nM
Cc1ccc(NC(=O)c2cccc3cc(-c4cccc5[nH]nc(N)c45)ccc23)cc1 CHEMBL3288505 IC50 1.3 nM
CS(=O)(=O)Cc1ccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5ccccc5)cccc4c3)n2)cc1 CHEMBL3740673 IC50 1.3 nM
CS(=O)(=O)Nc1cccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5ccccc5)cccc4c3)n2)c1 CHEMBL3740276 IC50 1.3 nM
O=C(Nc1cccc(Nc2ccc3c(/C=C/c4ccccc4)n[nH]c3c2)c1)c1ccccc1 CHEMBL3985867 Ki 1.3 nM
CC(=O)c1cccc(C(=O)Nc2cccc(N(C)c3ccc4c(/C=C/c5ccc6c(c5)OCO6)n[nH]c4c3)c2)c1 CHEMBL3984623 Ki 1.3 nM
CC(=O)N1Cc2ncnc(Oc3ccc4c(ccn4C(=O)Nc4cc(C5CC5)on4)c3)c2C[C@@H]1C CHEMBL4077373 IC50 1.3 nM
O=C(Nc1cccc(C(F)(F)F)c1)c1cccc2cc(Oc3cc(CO)ncn3)ccc12 CHEMBL4080062 IC50 1.3 nM
COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(-c5cnn(C)c5)cc4c3N(C)C2=O)c1F CHEMBL4871581 IC50 1.3 nM
CC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)ncn1 CHEMBL4845883 IC50 1.3 nM
O=C(Nc1ccc(-c2ccc(=O)[nH]n2)cc1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL5208686 IC50 1.3 nM
Cc1cccc(-c2cn(Cc3ccc(-c4cccnc4)cc3)nn2)c1 CHEMBL4570075 IC50 1.33 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(C(=O)Nc5cc(C(F)(F)F)cc(C(F)(F)F)c5)CC4)cc3)c12 CHEMBL4075266 IC50 1.35 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccc5c(c4)OCO5)cc3)c12 CHEMBL3633684 IC50 1.38 nM
Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c2)on1 CHEMBL2349000 IC50 1.4 nM
Cc1ccc(C(=O)Nc2ccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c(F)c2)c(=O)n1-c1ccccc1 CHEMBL3093582 IC50 1.4 nM
Nc1n[nH]c2cccc(-c3ccc4c(C(=O)Nc5cc(Cl)cc(Cl)c5)cccc4c3)c12 CHEMBL3288518 IC50 1.4 nM
CCc1cccc(NC(=O)c2cccc3cc(-c4cccc5[nH]nc(N)c45)ccc23)c1 CHEMBL3288506 IC50 1.4 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5ccc(F)cc5)cccc4c3)n2)c1 CHEMBL3742168 IC50 1.4 nM
C=CCOc1cc(-c2ccc3c(/C=C/c4ccc(OC)c(OC)c4)n[nH]c3c2)ccc1O CHEMBL3935733 Ki 1.4 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(C(=O)Nc5ccc(F)c(F)c5)CC4)cc3)c12 CHEMBL4100979 IC50 1.4 nM
Cc1ccc(NC(=O)Cn2cc(-c3ccc4c(NC(=O)C5CC5)n[nH]c4c3)cn2)cc1C(F)(F)F CHEMBL4858003 IC50 1.4 nM
COc1ccc(Nc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)nn1 CHEMBL5177149 IC50 1.4 nM
Nc1ncc2ccc(-c3ccc(NC(=S)Nc4ccc(Br)cc4OC(F)(F)F)cc3)cc2n1 CHEMBL4089043 IC50 1.42 nM
COc1cc2c(NC3=CC(=O)C(OCC#Cc4ccccc4)=CC3=O)ncnc2cc1OCCCN1CCCC1 CHEMBL3706842 IC50 1.5 nM
CN1CCN(CC(=O)Nc2nc3ccc(Oc4ccc(NC(=O)Nc5cc(C(F)(F)F)ccc5F)cc4)cc3[nH]2)CC1 CHEMBL389333 IC50 1.5 nM
Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)cncc21 CHEMBL404366 IC50 1.5 nM
Cc1nc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2C)c(C)s1 CHEMBL2409784 IC50 1.5 nM
CNC(C(=O)Nc1cccc(C(=O)c2ccc3c(/C=C/c4ccccc4)n[nH]c3c2)c1)c1ccccc1 CHEMBL3933094 Ki 1.5 nM
COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c2c2c1OCCO2 CHEMBL4466426 IC50 1.5 nM
O=C(Nc1ccc(Oc2ncnc3cc(OCCCN4CCOCC4)c4c(c23)OCCO4)cc1)Nc1cc(C(F)(F)F)ccc1F CHEMBL4449250 IC50 1.5 nM
COc1cc2c(Oc3ccc(NC(=O)NCc4ccc(F)cc4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5433332 IC50 1.5 nM
Cc1cc(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)ccc1F CHEMBL374044 pKi 1.585 nM
Cc1cc(NC(=O)Nc2ccc(-c3c(F)ccc4[nH]nc(N)c34)cc2)ccc1F CHEMBL1993996 pKi 1.585 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c2cc1OC CHEMBL362188 IC50 1.6 nM
CN1CCC[C@@H]1COc1cc(Nc2nc3cc(Oc4ccnc5[nH]ccc45)ccc3o2)ccc1Cl CHEMBL230222 Ki 1.6 nM
COc1ccccc1NC(=O)c1ccc(CSc2nnc3c(n2)[nH]c2ccccc23)cc1 CHEMBL1290030 IC50 1.6 nM
Cc1ccc(Oc2ccc3nc(NC(=O)C4CC4)nn3c2)cc1NC(=O)c1ccnn1C CHEMBL2409787 IC50 1.6 nM
Cc1[nH]c2c(c1C(=O)NCCN1CCOCC1)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430258 IC50 1.6 nM
Nc1n[nH]c2cccc(-c3ccc4c(C(=O)Nc5ccccc5)cccc4c3)c12 CHEMBL3288502 IC50 1.6 nM
Nc1n[nH]c2cccc(-c3ccc4c(C(=O)Nc5cc(F)cc(F)c5)cccc4c3)c12 CHEMBL3288515 IC50 1.6 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C[C@H](C)O)c5)cnc(N)c34)cc2)c1 CHEMBL3646210 IC50 1.6 nM
CS(=O)(=O)c1cccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5ccccc5)cccc4c3)n2)c1 CHEMBL3741592 IC50 1.6 nM
O=C(Nc1cccc(Sc2ccc3c(/C=C/c4ccccc4)n[nH]c3c2)c1)c1ccccc1 CHEMBL3960801 Ki 1.6 nM
C=C(c1cccc(NC(C)=O)c1)c1ccc2c(/C=C/c3ccccc3)n[nH]c2c1 CHEMBL3927752 Ki 1.6 nM
CN(c1cccc(NC(=O)OCc2ccccc2)c1)c1ccc2c(/C=C/c3ccccc3)n[nH]c2c1 CHEMBL3930218 Ki 1.6 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N2C(=O)CC[C@H]2CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL4171244 IC50 1.6 nM
CC(=O)Nc1n[nH]c2cc(-c3cnn(CC(=O)Nc4ccc(C)c(C(F)(F)F)c4)c3)ccc12 CHEMBL4870465 IC50 1.6 nM
COc1ccc(-c2ccc(Cn3cc(-c4cccc(Cl)c4)nn3)cc2)cn1 CHEMBL4452256 IC50 1.63 nM
c1cc(N2CCOCC2)ccc1-c1cnc2c(-c3cn[nH]c3)cnn2c1 CHEMBL2385579 IC50 1.68 nM
COCCOc1cc2ncnc(NC3=CC(=O)C(Cl)=C(OC)C3=O)c2cc1OC CHEMBL3706822 IC50 1.7 nM
COCCOc1cc2ncnc(NC3=CC(=O)C(OCCOc4ccccc4)=CC3=O)c2cc1OC CHEMBL3706819 IC50 1.7 nM
Nc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)c12 CHEMBL255955 IC50 1.7 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(S(=O)(=O)C4CCNCC4)cc3)nc12 CHEMBL250625 IC50 1.7 nM
COc1cc2ncnc(Nc3ccc4c(C)n[nH]c4c3)c2cc1OC CHEMBL515625 IC50 1.7 nM
CO/N=C/c1c(N)ncnc1Oc1ccc(NC(=O)Nc2cccc(F)c2)c(Cl)c1 CHEMBL1681951 IC50 1.7 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5ccncc5)cccc4c3)n2)c1 CHEMBL3741311 IC50 1.7 nM
O=C(Nc1cccc(Oc2ccc3c(/C=C/c4cccs4)n[nH]c3c2)c1)c1ccccc1 CHEMBL3959522 Ki 1.7 nM
O=C(Nc1cccc(C(=O)c2ccc3c(-c4nc5cccnc5[nH]4)n[nH]c3c2)c1)c1ccccc1 CHEMBL3889849 Ki 1.7 nM
O=C(NC1CC1)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL3907423 Ki 1.7 nM
Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(F)ccc3O)cc12 CHEMBL4062877 IC50 1.7 nM
Nc1nccc(Oc2ccc3c(C(=O)Nc4cccc(C(F)(F)F)c4)cccc3c2)n1 CHEMBL4104297 IC50 1.7 nM
COCCOc1cc2ncnc(Oc3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c2c2c1OCCO2 CHEMBL4528373 IC50 1.7 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4c(F)cccc4F)cc3)c2cc1OC CHEMBL179307 IC50 1.8 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(F)cc(F)c4)cc3)c2cc1OC CHEMBL179816 IC50 1.8 nM
Nc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4ccc(F)c(Cl)c4)cc3)c12 CHEMBL256205 IC50 1.8 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cncc4c3c(N)nn4C)cc2)c1 CHEMBL404367 IC50 1.8 nM
Cc1cc(C(=O)Nc2ccc(C)c(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c2)n(C)n1 CHEMBL2348994 IC50 1.8 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Nc3ccc4c(C(=O)Nc5ccccc5)cccc4c3)n2)c1 CHEMBL3741316 IC50 1.8 nM
CNC(=O)c1cccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5ccccc5)cccc4c3)n2)c1 CHEMBL3740574 IC50 1.8 nM
CC(=O)Nc1cccc(N(C)c2ccc3c(/C=C/c4ccccc4)n[nH]c3c2)c1 CHEMBL3953791 Ki 1.8 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C[C@H](O)CO)c5)cnc(N)c34)cc2)cc1 CHEMBL3646211 IC50 1.83 nM
COc1ccc(-c2ccc(Cn3cc(-c4cccc(N)c4)nn3)cc2)cn1 CHEMBL4441465 IC50 1.85 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4cccc(OC(F)(F)F)c4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5432573 IC50 1.85 nM
COc1cc2ncnc(Oc3ccc(NC(=O)NC4CC4)c4ccccc34)c2cc1OC CHEMBL4071203 IC50 1.88 nM
COCCOc1cc2ncnc(NC3=CC(=O)C(Cl)=C(OC(C)C)C3=O)c2cc1OC CHEMBL3706832 IC50 1.9 nM
Cc1ccc(Oc2ccc3nc(NC(=O)C4CC4)nn3c2)cc1NC(=O)c1cn(C)nc1C CHEMBL2409786 IC50 1.9 nM
Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2C)n(C)n1 CHEMBL2409776 IC50 1.9 nM
CCn1c(=O)c(-c2ccc(F)c(NC(=O)Nc3cc(C(C)(C)C)no3)c2)cc2cnc(NC)cc21 CHEMBL3577115 IC50 1.9 nM
CN1CCN(CC(=O)N(C)c2ccc(N/C(=C3\C(=O)Nc4cc(-n5nccn5)ccc43)c3ccccc3)cc2)CC1 CHEMBL4177014 IC50 1.9 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4ccccc4)c(F)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5424131 IC50 1.95 nM
COc1cc2ncnc(Oc3ccc4c(C(=O)Nc5ccc(Cl)cc5)cccc4c3)c2cc1OC CHEMBL272823 pIC50 1.995 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5ccccc5F)cccc4c3)c2cc1OC CHEMBL270547 pIC50 1.995 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5ccc(Cl)cc5Cl)cccc4c3)c2cc1OC CHEMBL270983 pIC50 1.995 nM
COc1cc2nccc(Oc3ccc4c(C(=O)Nc5ccncc5)cccc4c3)c2cc1OC CHEMBL272693 pIC50 1.995 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(-c3cccc4onc(N)c34)cc2)c1 CHEMBL409349 pKi 1.995 nM
CN(c1ccc(NC(=O)Nc2cc(C(F)(F)F)ccc2F)cc1)c1ccnc(Nc2ccc(CS(C)(=O)=O)cc2)n1 CHEMBL188997 IC50 2.0 nM
CN(c1ccc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1)c1ccnc(Nc2cccc(S(N)(=O)=O)c2)n1 CHEMBL188381 IC50 2.0 nM
CN(c1ccc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1)c1ccnc(Nc2ccc(S(N)(=O)=O)cc2)n1 CHEMBL188025 IC50 2.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2F)c1 CHEMBL371510 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2nc(N)ncc2c1 CHEMBL385937 IC50 2.0 nM
CCCn1c2ccc(NC(=O)OCC)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL219493 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(CCCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncccc1-c1ccncn1 CHEMBL221484 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1C#Cc1cnc(N)nc1 CHEMBL427998 IC50 2.0 nM
CS(=O)(=O)N1CCN(Cc2ccnc(Nc3ncc(-c4ccccc4)s3)c2)CC1 CHEMBL224035 IC50 2.0 nM
CN1CCN(Cc2ccc3c(c2)Cc2c(-c4csc(C#CCOc5ccccc5)c4)n[nH]c2-3)C(=O)C1 CHEMBL225334 IC50 2.0 nM
CN1CCN(Cc2cc(Nc3nc4cc(Oc5ccnc6ccccc56)cc(Cl)c4o3)ccc2Cl)CC1 CHEMBL387591 Ki 2.0 nM
CN1CCN(Cc2cc(Nc3nc4cc(Oc5ccnc6[nH]ccc56)ccc4o3)ccc2Cl)CC1 CHEMBL387590 Ki 2.0 nM
CN1CCN(Cc2cc(Nc3nc4cc(Oc5ccnc6ccccc56)ccc4[nH]3)ccc2Cl)CC1 CHEMBL397496 Ki 2.0 nM
CNC(=O)c1cc(Oc2ccc3[nH]c(Nc4ccc(C(F)(F)F)c(OC[C@H]5CCCN5C)c4)nc3c2)ccn1 CHEMBL231269 Ki 2.0 nM
CNc1nccc(-c2cccnc2Oc2cc(NC(=O)c3cccc(C(C)C)c3)ccc2C)n1 CHEMBL394693 IC50 2.0 nM
O=C(Nc1cccc(Cl)c1)c1cccnc1NCc1ccncc1 CHEMBL401153 Ki 2.0 nM
O=C(Nc1ccc(C2CCCCC2)cc1)c1cccnc1NCc1ccncc1 CHEMBL250482 Ki 2.0 nM
CCO/N=C(\C)c1ccc2[nH]c3c4c(c5c(c3c2c1)CNC5=O)-c1cn(C)nc1CC4 CHEMBL404718 IC50 2.0 nM
C/C(=N\OCC(C)C)c1ccc2c(c1)c1c3c(c4c(c1n2C(C)C)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL258436 IC50 2.0 nM
Nc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4ccc(F)c(C(F)(F)F)c4)cc3)c12 CHEMBL403439 IC50 2.0 nM
Cn1cc2c(n1)CCc1c-2c2c(c3c1[nH]c1ccc(C(=O)c4cccs4)cc13)CNC2=O CHEMBL428876 IC50 2.0 nM
COc1cc2nccc(Oc3ccc4c(NC(=O)Nc5ccccc5)nn(C)c4c3)c2cc1OC CHEMBL508643 IC50 2.0 nM
COc1cc2nccc(Oc3ccc4c(NC(=O)Nc5ccc(C)cc5)nn(C)c4c3)c2cc1OC CHEMBL509707 IC50 2.0 nM
COc1cc2nccc(Oc3ccc4c(Nc5ccccc5)cccc4c3)c2cc1OC CHEMBL462169 IC50 2.0 nM
COc1cc2nccc(Oc3ccc4c(NC(=O)c5cc(C(F)(F)F)cc(C(F)(F)F)c5)nn(C)c4c3)c2cc1OC CHEMBL450163 IC50 2.0 nM
COc1cc2nccc(Oc3ccc4c(NC(=O)c5cccc(C)c5)nn(C)c4c3)c2cc1OC CHEMBL518203 IC50 2.0 nM
COc1cc2nccc(Oc3ccc4c(NC(=O)c5cc(Cl)ccn5)nn(C)c4c3)c2cc1OC CHEMBL462175 IC50 2.0 nM
COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)=O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1 CHEMBL461293 Ki 2.0 nM
COc1cc2nccc(CN3CCc4c(C(=O)Nc5ccc(F)c(C(F)(F)F)c5)cccc4C3=O)c2cc1OC CHEMBL494872 IC50 2.0 nM
Cc1c(/C=C2\C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)N(CCN(C)C)CC2 CHEMBL1278234 IC50 2.0 nM
CCN(CC)CCN1CCc2[nH]c(/C=C3\C(=O)Nc4ccc(F)cc43)c(C)c2C1=O CHEMBL1278146 IC50 2.0 nM
COc1cc(O)c2c(c1)CCC[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O CHEMBL2012519 IC50 2.0 nM
Cc1cc(F)c(Nc2ncnc3cc(OCc4ccccc4)ccc23)cc1O CHEMBL1558704 IC50 2.0 nM
CO/N=C/c1c(N)ncnc1Oc1ccc(NC(=O)Nc2nc(C)c(C)s2)c(Cl)c1 CHEMBL1681944 IC50 2.0 nM
CO/N=C/c1c(N)ncnc1Oc1ccc(NC(=O)Nc2cc(C)on2)c(Cl)c1 CHEMBL1681945 IC50 2.0 nM
COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccc5ccccc5c4)c(C)c3)c2cc1OC CHEMBL2018886 IC50 2.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cn[nH]c5)cnc(N)c34)cc2)c1 CHEMBL1969102 IC50 2.0 nM
Cc1ccccc1NC(=O)Nc1ccc(-c2csc3c(-c4cnn(C)c4)cnc(N)c23)cc1 CHEMBL2023225 IC50 2.0 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(C(N)=O)c5)cc4)csc23)cn1 CHEMBL2022850 IC50 2.0 nM
Nc1ncc(-c2cnn(CCCN3CC[C@@H](O)C3)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL2022857 IC50 2.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cnn(C4CCNCC4)c3)ncc2Cl)[C@H]2C=C[C@@H]1C2 CHEMBL2071275 IC50 2.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cnn([C@@H]4CCCNC4)c3)ncc2Cl)[C@H]2C=C[C@@H]1C2 CHEMBL2071276 IC50 2.0 nM
Cc1ccc(Oc2ccc3nc(NC(=O)C4CC4)nn3c2)cc1NC(=O)CC(C)C CHEMBL2409788 IC50 2.0 nM
Cc1cc(NC(=O)c2cccc3cc(Oc4ccnc(Nc5cccc(CS(C)(=O)=O)c5)n4)ccc23)no1 CHEMBL3739633 IC50 2.0 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5ccccc5F)cccc4c3)n2)c1 CHEMBL3739936 IC50 2.0 nM
CCS(=O)(=O)c1cccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5ccccc5)cccc4c3)n2)c1 CHEMBL3739835 IC50 2.0 nM
CC(C)c1cc(NC(=O)n2ccc3cc(Oc4ncnc5c4CNC5)ccc32)no1 CHEMBL3747273 IC50 2.0 nM
Cc1ccoc1C(=O)Nc1cccc(C#Cc2cncc(C(=O)N=S(C)(C)=O)c2)c1 CHEMBL3917187 IC50 2.0 nM
Cc1ccoc1C(=O)Nc1cccc(C#Cc2cncc(C(=O)N=S3(=O)CCCC3)c2)c1 CHEMBL3986945 IC50 2.0 nM
Cc1ccoc1C(=O)Nc1cccc(C#Cc2cc(C(=O)N=S3(=O)CCCC3)cnc2N)c1 CHEMBL3914411 IC50 2.0 nM
CS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3ccc(Cl)cc3)c2)c1 CHEMBL3901672 IC50 2.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(C(=O)Nc3cccc(C)c3)c2)c1 CHEMBL3911919 IC50 2.0 nM
Cc1ccoc1C(=O)Nc1cccc(C#Cc2cc(C(=O)N=S(C)(=O)CCCO)cnc2N)c1 CHEMBL3934064 IC50 2.0 nM
COC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1 CHEMBL3911339 IC50 2.0 nM
COC(=O)[C@@H]1C[C@@H](O)CN1CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1 CHEMBL4109002 IC50 2.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(C(=O)NCCCC(=O)O)sc34)cc2)c1 CHEMBL3897945 IC50 2.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(C(=O)NCCCN5CCN(C)CC5)sc34)cc2)c1 CHEMBL3906088 IC50 2.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(C(=O)N=S(C)(C)=O)sc34)cc2)c1 CHEMBL3924912 IC50 2.0 nM
CNCc1cc(Oc2ccc3c(ccn3C(=O)Nc3cc(C4(C)CC4)[nH]n3)c2)ncn1 CHEMBL4086718 IC50 2.0 nM
CN1CCN(Cc2ccc(NC(=O)CCSc3ccc4c(/C=C/c5ccccn5)n[nH]c4c3)cc2C(F)(F)F)CC1 CHEMBL4439424 GI50 2.0 nM
CN1CCN(Cc2ccc(NC(=O)CCSc3ccc4c(/C=C/c5ccncc5)n[nH]c4c3)cc2C(F)(F)F)CC1 CHEMBL4783676 GI50 2.0 nM
CN1CCN(Cc2ccc(NC(=O)CCSc3ccc4c(/C=C/c5cnccn5)n[nH]c4c3)cc2C(F)(F)F)CC1 CHEMBL4781338 GI50 2.0 nM
COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)c2cc1OC CHEMBL4856992 IC50 2.0 nM
Nc1cc(Oc2ccc3c(C(=O)Nc4cccc(C(F)(F)F)c4)cccc3c2)ncn1 CHEMBL5288744 IC50 2.0 nM
CN(C)CCOc1ccc(NC(=O)c2cccc(-c3cccc(O)c3)c2)cc1F CHEMBL3397933 IC50 2.02 nM
COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)cc2s1 CHEMBL244482 IC50 2.1 nM
Cc1cccc(NC(=O)N2CCc3nc(-c4cc5ccccc5[nH]c4=O)[nH]c3C2)c1 CHEMBL2016928 IC50 2.1 nM
Cc1cc(NC(=O)c2cc(C)nn2C)cc(Oc2ccc3nc(NC(=O)C4CC4)nn3c2)c1 CHEMBL2409777 IC50 2.1 nM
Cc1cccc(NC(=O)c2cccc3cc(-c4cccc5[nH]nc(N)c45)ccc23)c1 CHEMBL3288504 IC50 2.1 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc4c(C(N)=O)cccc4c3)n2)c1 CHEMBL3741965 IC50 2.1 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5cccc(Br)c5)cccc4c3)n2)c1 CHEMBL3740087 IC50 2.1 nM
CC(=O)N1CCc2c(ncnc2Oc2ccc3c(ccn3C(=O)Nc3cc(C4CC4)on3)c2)C1 CHEMBL4092692 IC50 2.1 nM
C=CC(=O)Nc1ccc(-c2ccc(NC(=O)Nc3cccc(C(C)C)c3)cc2)cn1 CHEMBL4175773 IC50 2.1 nM
Nc1n[nH]c2cccc(-c3cccc(NC(=O)Nc4ccc(F)cc4)c3)c12 CHEMBL3633292 IC50 2.15 nM
O=C(Nc1ccc(-c2cccnc2)cc1)Nc1ccc(Cl)c(Cl)c1 CHEMBL3586056 IC50 2.19 nM
COc1ccc(NC(=O)Nc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)cc1 CHEMBL179603 IC50 2.2 nM
COc1cc2c(NC3=CC(=O)C(OCc4ccccn4)=CC3=O)ncnc2cc1OCCCN1CCCC1 CHEMBL2113199 IC50 2.2 nM
Cc1ccccc1NC(=O)Nc1ccc(-c2ccnc3[nH]nc(N)c23)cc1 CHEMBL257292 IC50 2.2 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12 CHEMBL400402 IC50 2.2 nM
CN(c1ccc2c(C(=O)Nc3ccccc3)cccc2c1)c1ccnc(Nc2cccc(CS(C)(=O)=O)c2)n1 CHEMBL3741876 IC50 2.2 nM
Cc1ccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5ccccc5)cccc4c3)n2)cc1S(C)(=O)=O CHEMBL3740788 IC50 2.2 nM
Oc1ccc(-c2ccc3c(/C=C/c4ccccc4)n[nH]c3c2)cc1OCc1ccccc1 CHEMBL3898428 Ki 2.2 nM
CC(=O)N1CCC(C(=O)Nc2cccc(Oc3ccc4c(/C=C/c5ccc(Cl)cc5)n[nH]c4c3)c2)CC1 CHEMBL3945525 Ki 2.2 nM
CC(C)c1cccc(NC(=O)Nc2cccc(-c3cccc4[nH]nc(N)c34)c2)c1 CHEMBL3633296 IC50 2.28 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4C)cc3)c2cc1OC CHEMBL179061 IC50 2.3 nM
COCCOc1cc2ncnc(NC3=CC(=O)C(Cl)=C(OCC4CC4)C3=O)c2cc1OC CHEMBL2113191 IC50 2.3 nM
COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)nc2[nH]1 CHEMBL244101 IC50 2.3 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 2.3 nM
CNC(=O)c1ncc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(CCO)CC4)c(C(F)(F)F)c3)ccc2C)n1C CHEMBL1784637 IC50 2.3 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(C)cc21 CHEMBL2430266 IC50 2.3 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2180602 IC50 2.3 nM
Nc1n[nH]c2cccc(-c3ccc4c(C(=O)Nc5cccc(F)c5)cccc4c3)c12 CHEMBL3288512 IC50 2.3 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL223360 IC50 2.3 nM
Cc1ccc(S(C)(=O)=O)cc1Nc1nccc(Oc2ccc3c(C(=O)Nc4ccccc4)cccc3c2)n1 CHEMBL3741187 IC50 2.3 nM
COc1cc2ncnc(Nc3cc(O)c(C)cc3F)c2cc1OC CHEMBL440727 IC50 2.3 nM
CC1(c2cc(NC(=O)n3ccc4cc(Oc5ncnc6c5CCNC6)ccc43)n[nH]2)CC1 CHEMBL3746562 IC50 2.3 nM
Cc1ccc(NC(=O)Cn2cc(-c3ccc4c(NC(=O)c5cccnc5)n[nH]c4c3)cn2)cc1C(F)(F)F CHEMBL4872941 IC50 2.3 nM
Nc1cc(Oc2ccc3c(C(=O)Nc4ccc(F)c(C(F)(F)F)c4)cccc3c2)ncn1 CHEMBL5280119 IC50 2.3 nM
C=CC(=O)Nc1ccc(-c2ccc(NC(=O)Nc3cccc(Cl)c3)cc2)cn1 CHEMBL4171543 IC50 2.35 nM
Cc1ccc(NC(=O)Nc2cccc(-c3cccc4[nH]nc(N)c34)c2)cc1 CHEMBL3633295 IC50 2.36 nM
[2H]C([2H])([2H])Oc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC([2H])([2H])[2H] CHEMBL3426917 IC50 2.38 nM
COc1cc2c(NC3=CC(=O)C(OCC(F)F)=CC3=O)ncnc2cc1OCCCN1CCCC1 CHEMBL2113164 IC50 2.4 nM
Nc1c(C(=O)c2cc3cc(CN4CCOCC4)ccc3[nH]2)cnn1-c1cc(O)ccc1Cl CHEMBL3984621 IC50 2.4 nM
COc1ccc(N2C(=O)CS/C2=N/Nc2nncc3ccccc23)cc1 CHEMBL3974626 IC50 2.4 nM
Oc1cccc(Oc2ccc3c(/C=C/c4ccccc4)n[nH]c3c2)c1 CHEMBL3912858 Ki 2.4 nM
COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)cc3)c2c2c1OCCO2 CHEMBL4514617 IC50 2.4 nM
O=C(Nc1cc(C(F)(F)F)ccc1F)Nc1ccc(Oc2ncnc3cc(OCCCN4CCOCC4)c4c(c23)OCCO4)cc1Cl CHEMBL4581503 IC50 2.4 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4ccc(C(F)(F)F)cc4)c(F)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5409075 IC50 2.44 nM
COc1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)cc(OC)c1OC CHEMBL201511 IC50 2.5 nM
CO/N=C/c1c(N)ncnc1Oc1ccc(NC(=O)Nc2ccccc2OC)c(Cl)c1 CHEMBL1681949 IC50 2.5 nM
CCN(CC)CC(O)CNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430250 IC50 2.5 nM
Nc1n[nH]c2cccc(-c3ccc4c(C(=O)Nc5cc(Br)cc(Br)c5)cccc4c3)c12 CHEMBL3288519 IC50 2.5 nM
CC(Oc1ccc2[nH]nc(-c3nc4cc(N(C)C(=O)CN(C)C)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3828439 IC50 2.5 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)N1CCOCCOCCOCC1 CHEMBL3950152 IC50 2.5 nM
CN1CCN(Cc2ccc(NC(=O)c3cccc(C#Cc4cncc5ccccc45)c3)cc2C(F)(F)F)CC1 CHEMBL4081243 IC50 2.5 nM
CNCc1cc(Oc2ccc3c(ccn3C(=O)Nc3cc(C4(C(F)(F)F)CC4)[nH]n3)c2)ncn1 CHEMBL4064471 IC50 2.5 nM
CC(C)(CO)c1cc(NC(=O)n2ccc3cc(Oc4ncnc5c4CNC5)ccc32)no1 CHEMBL4079136 IC50 2.5 nM
O=C(Nc1ccc(Oc2ncnc3[nH]ccc23)cc1)Nc1cccc(C(F)(F)F)c1 CHEMBL4869054 IC50 2.5 nM
CNc1cc(Oc2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)c(F)c2F)ncn1 CHEMBL4857556 IC50 2.5 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 pKi 2.512 nM
Cc1cccc(-c2cn(Cc3ccc(-c4cncnc4)cc3)nn2)c1 CHEMBL4553163 IC50 2.57 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3Cl)c2cc1OC CHEMBL360349 IC50 2.6 nM
CCNc1cccc(OC2=CC(=O)C(Nc3ncnc4cc(OCCOC)c(OC)cc34)=CC2=O)c1 CHEMBL202389 IC50 2.6 nM
CC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)cc2[nH]1 CHEMBL243916 IC50 2.6 nM
Cc1c2ccc(N(C)c3ccnc(Nc4cccc(S(N)(=O)=O)c4)n3)cc2nn1Cc1ccccc1 CHEMBL476572 IC50 2.6 nM
CO/N=C/c1c(N)ncnc1Oc1ccc(NC(=O)Nc2ccccc2Cl)c(Cl)c1 CHEMBL1681947 IC50 2.6 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(Cl)cc21 CHEMBL2430264 IC50 2.6 nM
Nc1n[nH]c2cccc(-c3ccc4c(C(=O)Nc5ccc(F)cc5F)cccc4c3)c12 CHEMBL3288514 IC50 2.6 nM
C(=C/c1n[nH]c2cc(Sc3ccccc3)ccc12)\c1ccccc1 CHEMBL3915562 Ki 2.6 nM
O=CNc1ccccc1/C=C/c1n[nH]c2cc(C(=O)c3cccc(NC(=O)c4ccccc4)c3)ccc12 CHEMBL3986713 Ki 2.6 nM
CN1CCN(Cc2ccc(NC(=O)c3cncc(C#Cc4cncc5ccccc45)c3)cc2C(F)(F)F)CC1 CHEMBL4062884 IC50 2.6 nM
Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3ccc(F)cc3O)cc12 CHEMBL4075917 IC50 2.6 nM
CCCCNC(=O)Nc1ccc(Oc2ncnc3cc(OCCCN4CCCC4)c(OC)cc23)cc1Cl CHEMBL5436823 IC50 2.65 nM
COCCOc1cc2ncnc(NC3=CC(=O)C(Oc4ccccc4)=CC3=O)c2cc1OC CHEMBL2113174 IC50 2.7 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(CCCN4CCCC4)cc3)nc12 CHEMBL250213 IC50 2.7 nM
Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cc(C(F)(F)F)ccn4)c(Cl)c3)c21 CHEMBL1254193 IC50 2.7 nM
O=C(Nc1cccc(C(F)(F)F)c1)Nc1ccc(Oc2ncnc3ccn(CCOCCO)c23)cc1Cl CHEMBL1253837 IC50 2.7 nM
Cc1cccc(NC(=O)Nc2ccc(Oc3ncnc4ccn(C)c34)cc2)c1 CHEMBL1254923 IC50 2.7 nM
O=C(Nc1cccc(Oc2ccc3nc(NC(=O)C4CCOCC4)cn3n2)c1)c1cccc(F)c1 CHEMBL2349011 IC50 2.7 nM
CCN(CC)CCCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430247 IC50 2.7 nM
O=C1CS/C(=N/Nc2nncc3ccccc23)N1c1ccc(Cl)cc1 CHEMBL3912723 IC50 2.7 nM
Cc1ccc(NC(=O)Cn2cc(-c3ccc4c(N)n[nH]c4c3)cn2)cc1C(F)(F)F CHEMBL4853592 IC50 2.7 nM
Cc1ccc(NC(=O)Cn2cc(-c3ccc4c(NC(=O)c5ccc(N)cc5)n[nH]c4c3)cn2)cc1C(F)(F)F CHEMBL5272444 IC50 2.7 nM
Cc1ncc([N+](=O)[O-])n1CCOc1ncnc2ccccc12 CHEMBL3310053 IC50 2.72 nM
COc1cc2c(Oc3ccc(NC(=O)NC4CCC4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5414550 IC50 2.74 nM
CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(Cl)c(OC[C@@H]5CCCN5C)c4)nc3c2)ccn1 CHEMBL231568 Ki 2.8 nM
CO/N=C/c1c(N)ncnc1Oc1ccc(NC(=O)Nc2ccc(F)cc2)c(Cl)c1 CHEMBL1681952 IC50 2.8 nM
Cc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c(F)c1 CHEMBL3093584 IC50 2.8 nM
N#CC1(c2cccc(C(=O)Nc3cc(Oc4ccc5nc(NC(=O)C6CC6)sc5n4)ccc3F)c2Cl)CC1 CHEMBL2063743 IC50 2.8 nM
Nc1n[nH]c2cccc(-c3ccc4c(C(=O)NC5CC5)cccc4c3)c12 CHEMBL3288523 IC50 2.8 nM
C#CCNC(=O)c1ccccc1Nc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL3913600 Ki 2.8 nM
CN(c1cccc(NC(=O)c2ccc(C(C)(C)C)c(O)c2)c1)c1ccc2c(/C=C/c3ccc4c(c3)OCO4)n[nH]c2c1 CHEMBL3897567 Ki 2.8 nM
CNCc1cc(Oc2ccc3c(ccn3C(=O)Nc3cc(C(C)C)[nH]n3)c2)ncn1 CHEMBL4103267 IC50 2.8 nM
COc1cc2ncnc(Oc3ccc4c(C(=O)NC5CC5)cccc4c3)c2cc1OC CHEMBL411284 pIC50 2.884 nM
CCc1cccc(NC(=O)Nc2ccc(Oc3ccc4nc(NC(=O)OC)[nH]c4c3)cc2)c1 CHEMBL243907 IC50 2.9 nM
Cc1ccc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(N)c34)cc2)cc1 CHEMBL255956 IC50 2.9 nM
Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cncc(C(F)(F)F)c4)c(Cl)c3)c21 CHEMBL1254277 IC50 2.9 nM
CCOC(=O)CSc1nc2c(c(=O)[nH]c(=O)n2C)n1Cc1cccc(C)c1 CHEMBL1290362 IC50 2.9 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 2.9 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5ccc(F)cc5F)cccc4c3)n2)c1 CHEMBL3741411 IC50 2.9 nM
Cc1c(C(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)c(=O)n(-c2ccccc2)n1C CHEMBL3703197 Kd 2.9 nM
CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(N5CCN(C)CC5)cc4)c3)ccc12 CHEMBL4290371 IC50 2.9 nM
COc1cc2c(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5406253 IC50 2.92 nM
O=C(c1cccc(NC(=O)C2CC2)c1)c1ccc2[nH]nc(/C=C/c3ccccn3)c2c1 CHEMBL3891951 Ki 2.95 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4cnn(C)c4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5406841 IC50 2.96 nM
COc1cccc(Nc2ncc(-c3ccccc3)s2)n1 CHEMBL99832 IC50 3.0 nM
c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 CHEMBL333021 IC50 3.0 nM
CCCc1c(C(=O)OCC)cn2ncnc(Nc3ccc(C)c(O)c3)c12 CHEMBL359652 IC50 3.0 nM
CC(=O)c1ccc(NC(=O)Nc2ccc(N(C)c3ccnc(Nc4cccc(CS(C)(=O)=O)c4)n3)cc2)cc1 CHEMBL189862 IC50 3.0 nM
COc1cc(OC)cc(-c2cc3cnc(NCCCCN4CCN(C)CC4)cc3nc2NC(=O)NC(C)(C)C)c1 CHEMBL190161 IC50 3.0 nM
COc1ccc(-c2oc3ncnc(N)c3c2-c2ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)cc2)cc1 CHEMBL194911 IC50 3.0 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12 CHEMBL382979 IC50 3.0 nM
COC1=CC(=O)C(Nc2ncnc3cc(OCCCN4CCCC4)c(OC)cc23)=CC1=O CHEMBL199455 IC50 3.0 nM
CNc1ncc2cc(-c3cc(C(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)ccc3C)ccc2n1 CHEMBL215019 IC50 3.0 nM
CCCOC(=O)Nc1ccc2c(c1)c1c3c(c4c(c1n2CCC)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL373575 IC50 3.0 nM
CCCn1c2ccc(NC(=O)c3ccco3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL425109 IC50 3.0 nM
CNc1nccc(-c2cccnc2Oc2cc(C(=O)Nc3cccc(C(F)(F)F)c3)ccc2C)n1 CHEMBL218632 IC50 3.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL220057 IC50 3.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3ccc(C)c4[nH]nc(N)c34)cc2)c1 CHEMBL219887 IC50 3.0 nM
c1ccc(-c2cnc(Nc3cc(CN4CCCC4)ccn3)s2)cc1 CHEMBL221875 IC50 3.0 nM
CN1CCN(Cc2ccc3c(c2)Cc2c(-c4csc(C#CCNC(=O)c5ccccc5)c4)n[nH]c2-3)CC1 CHEMBL225311 IC50 3.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3c(C)sc4ncnc(N)c34)cc2)c1 CHEMBL371329 IC50 3.0 nM
CNC(=O)c1cc(Oc2cc(F)c3oc(Nc4ccc(Cl)c(OC[C@@H]5CCCN5C)c4)nc3c2)ccn1 CHEMBL230223 Ki 3.0 nM
CN1CCC[C@H]1COc1cc(Nc2nc3cc(Oc4ccnc(C(N)=O)c4)ccc3o2)ccc1Cl CHEMBL230002 Ki 3.0 nM
CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(Cl)c(OCC5CCNCC5)c4)nc3c2)ccn1 CHEMBL425672 Ki 3.0 nM
CN1CCN(Cc2cc(Nc3nc4cc(Oc5ccnc6[nH]ccc56)ccc4[nH]3)ccc2Cl)CC1 CHEMBL397497 Ki 3.0 nM
CNC(=O)c1cc(Oc2ccc3[nH]c(Nc4ccc(C(F)(F)F)c(OCCN(C)C)c4)nc3c2)ccn1 CHEMBL231168 Ki 3.0 nM
CNC(=O)Nc1ccc(CNc2ncsc2C(=O)Nc2ccc3c(c2)OC(F)(F)O3)cn1 CHEMBL247250 IC50 3.0 nM
COc1ccc(-c2oc3ncnc(N)c3c2-c2ccc(NC(=O)Nc3c(F)cccc3C(F)(F)F)cc2)cc1 CHEMBL401860 IC50 3.0 nM
C/C(=N\OC(C)C)c1ccc2[nH]c3c4c(c5c(c3c2c1)CNC5=O)-c1cn(C)nc1CC4 CHEMBL258000 IC50 3.0 nM
CCn1c2ccc(/C(C)=N/OCC(C)C)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL401897 IC50 3.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cncc4c3c(N)nn4C)cc2)c1 CHEMBL402846 IC50 3.0 nM
COc1cc2nccc(Oc3ccc4c(c3)OCCN4C(=O)Nc3ccc(F)cc3)c2cc1OC CHEMBL272822 IC50 3.0 nM
CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(Cl)c(OC[C@H]5CCCN5C)c4)nc3c2)ccn1 CHEMBL429410 IC50 3.0 nM
CNC(=O)c1cc(Oc2ccc3c(C(=O)Nc4ccc(Cl)cc4)cccc3c2)ccn1 CHEMBL271181 IC50 3.0 nM
CCCn1c2ccc(C(C)=O)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL255405 IC50 3.0 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc1)CCN2 CHEMBL260092 IC50 3.0 nM
COc1cc2nccc(Oc3ccc4c(NC(=O)c5ccc(F)c(Cl)c5)nn(C)c4c3)c2cc1OC CHEMBL462003 IC50 3.0 nM
COc1cc2nccc(Oc3ccc4c(NC(=O)c5ccc(C(F)(F)F)cc5)nn(C)c4c3)c2cc1OC CHEMBL462349 IC50 3.0 nM
COc1ccc(C(=O)Nc2nn(C)c3cc(Oc4ccnc5cc(OC)c(OC)cc45)ccc23)cc1 CHEMBL462348 IC50 3.0 nM
CN1CCN(CCN(C)Cc2ccc(-c3cc4nccc(Oc5ccc(NC(=O)N6CCN(c7ccccc7)C6=O)cc5F)c4s3)cc2)CC1 CHEMBL508395 IC50 3.0 nM
CCn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)N5CCN(c6ccccc6F)C5=O)cc4F)c3s2)c1 CHEMBL517469 IC50 3.0 nM
COc1cc2nccc(CN3CCc4c(C(=O)Nc5ccc(Cl)c(C(F)(F)F)c5)cccc4C3=O)c2cc1OC CHEMBL494903 IC50 3.0 nM
COc1cc2nccc(CN3CCc4c(C(=O)Nc5cccc(C(F)(F)F)c5)cccc4C3=O)c2cc1OC CHEMBL492857 IC50 3.0 nM
Cn1cc2c(n1)CCc1c-2c2c(c3c4cc(C5CCCCO5)ccc4n(CCO)c13)CNC2=O CHEMBL1085293 IC50 3.0 nM
CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc21 CHEMBL572881 IC50 3.0 nM
CO/N=C/c1c(N)ncnc1Oc1ccc(NC(=O)Nc2ccccc2)c(Cl)c1 CHEMBL1681946 IC50 3.0 nM
CO/N=C/c1c(N)ncnc1Oc1ccc(NC(=O)Nc2ccc(F)cc2F)c(Cl)c1 CHEMBL1681953 IC50 3.0 nM
CC(C)n1c2ccc(Nc3ncccn3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL2010870 IC50 3.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)c1 CHEMBL1967116 IC50 3.0 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccccc5)cc4)csc23)cn1 CHEMBL2023226 IC50 3.0 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccccc5F)cc4)csc23)cn1 CHEMBL2023227 IC50 3.0 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1970317 IC50 3.0 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(OC(F)(F)F)cc5)cc4)csc23)cn1 CHEMBL2023232 IC50 3.0 nM
C[C@@H](O)Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL2022856 IC50 3.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cc[nH]n5)cnc(N)c34)cc2)c1 CHEMBL2023224 IC50 3.0 nM
CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)n[nH]1 CHEMBL2023485 IC50 3.0 nM
CCn1cc(Nc2ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)cn1 CHEMBL2071216 IC50 3.0 nM
COc1ccc2[nH]c(C(=C3C(=O)Nc4ccc(C(=O)O)cc43)c3ccccc3)nc2c1 CHEMBL2086742 IC50 3.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2cccc(F)c2)c2nc4ccccc4[nH]2)C(=O)N3)CC1 CHEMBL2086756 IC50 3.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2cc(F)cc(F)c2)c2nc(C)c[nH]2)C(=O)N3)CC1 CHEMBL2087168 IC50 3.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2nc(C)c[nH]2)c2ccccc2F)C(=O)N3)CC1 CHEMBL2087169 IC50 3.0 nM
CN1CCC(Nc2ccc3c(c2)/C(=C/c2cc4c([nH]2)CCN(C(=O)N2CCOCC2)C4)C(=O)N3)CC1 CHEMBL2403373 IC50 3.0 nM
Cc1ccc(Oc2ccc3nc(NC(=O)C4CC4)nn3c2)cc1NC(=O)C1CCC1 CHEMBL2409789 IC50 3.0 nM
Cc1[nH]c2c(c1C(=O)NCCN(C)C)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430261 IC50 3.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3nsc(NC(=O)NCCCN4CCOCC4)c3C(N)=O)cc2)c1 CHEMBL3696074 IC50 3.0 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5cc(Cl)cc(Cl)c5)cccc4c3)n2)c1 CHEMBL3739656 IC50 3.0 nM
Cc1ccc(NC(=O)c2cccc3cc(Oc4ccnc(Nc5cccc(CS(C)(=O)=O)c5)n4)ccc23)cc1 CHEMBL3741484 IC50 3.0 nM
CC(C)c1cc(NC(=O)n2ccc3cc(Oc4ncnc5c4CCNC5)ccc32)n[nH]1 CHEMBL3745943 IC50 3.0 nM
Cn1ccnc1-c1cc2c(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)ccnc2s1 CHEMBL3764474 IC50 3.0 nM
CC(C)(C)c1cc(NC(=O)n2ccc3ccc(Oc4ncnc5c4CNC5)cc32)no1 CHEMBL3808957 IC50 3.0 nM
CC(C)(C)c1cc(NC(=O)n2ccc3cc(Oc4ncnc5c4CNC5)ccc32)no1 CHEMBL3745816 IC50 3.0 nM
Cc1ccc(F)c(NC(=O)Nc2cccc(C#Cc3cncc(C(=O)N=S(C)(C)=O)c3)c2)c1 CHEMBL3985264 IC50 3.0 nM
Cc1ccoc1C(=O)Nc1cccc(C#Cc2cc(C(=O)N=S(C)(=O)CC(=O)N3CC[C@H](O)C3)cnc2N)c1 CHEMBL3909047 IC50 3.0 nM
Cc1ccoc1C(=O)Nc1cccc(C#Cc2cc(C(=O)N=S(=O)(CCCO)CCCO)cnc2N)c1 CHEMBL3924505 IC50 3.0 nM
O=C(N=S(=O)(CCCO)CCCO)c1cncc(C#Cc2cccc(NC(=O)c3ccc(Cl)c(C(F)(F)F)c3)c2)c1 CHEMBL3923411 IC50 3.0 nM
Cc1cccc(C(=O)Nc2cccc(C#Cc3cncc(C(=O)N=S(=O)(CCCO)CCCO)c3)c2)c1 CHEMBL3983308 IC50 3.0 nM
Cc1cccc(NC(=O)c2cccc(C#Cc3cc(C(=O)N=S(=O)(CCCO)CCCO)cnc3N)c2)c1 CHEMBL3900571 IC50 3.0 nM
Cc1ccoc1C(=O)Nc1cccc(C#Cc2cncc(C(=O)N=[S@@](C)(=O)CCCO)c2)c1 CHEMBL3909723 IC50 3.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(C(=O)NCCCc5nn[nH]n5)sc34)cc2)c1 CHEMBL3944753 IC50 3.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(C(=O)NCCCN5CCCC(CO)C5)sc34)cc2)c1 CHEMBL3932948 IC50 3.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(C(=O)NCCCN5CCN(C)CC5)sc34)cc2F)c1 CHEMBL3934764 IC50 3.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(C(=O)NCCCN5CCCC5)sc34)cc2F)c1 CHEMBL3986984 IC50 3.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(C(=O)N=S(C)(C)=O)sc34)cc2F)c1 CHEMBL3944578 IC50 3.0 nM
CCN(CC)CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1 CHEMBL3934424 IC50 3.0 nM
CCc1cccc(NC(=O)Nc2ccc(-c3cc4ccccc4n3C(N)=O)cc2)c1 CHEMBL3895384 IC50 3.0 nM
COc1cc2ncnc(-n3nc(Nc4ccc(N5CCN(C)CC5)cc4)nc3N)c2cc1OC CHEMBL4069483 EC50 3.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cc(C)nc4noc(N)c34)cc2)c1 CHEMBL4243470 IC50 3.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC CHEMBL2103868 IC50 3.0 nM
CC(C)(C)c1cc(NC(=O)Cc2ccc(-n3cnc4cc(-c5ccc(S(C)(=O)=O)cc5)ccc43)cc2)no1 CHEMBL4473213 IC50 3.0 nM
COC(=O)c1ccc2c(C(Nc3ccc(N(C)C(=O)CN4CCN(C)CC4)cc3)c3ccccc3)c(O)[nH]c2c1 CHEMBL5201102 IC50 3.0 nM
COc1cc(-c2cc(NC(=O)Nc3ccc(OCCCN4CCOCC4)cc3C)cc(OC)c2OC)ccc1/C(C)=N/O CHEMBL3099455 IC50 3.07 nM
Nc1n[nH]c2cccc(-c3ccc4c(C(=O)Nc5cccc(Cl)c5)cccc4c3)c12 CHEMBL3288516 IC50 3.1 nM
Cc1cc(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)c(F)c2)ccc1F CHEMBL1986979 pKi 3.162 nM
O=C(Nc1ccc(-n2cnc3ccccc32)cc1)Nc1cccc(C(F)(F)F)c1 CHEMBL1993510 pKi 3.162 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN5CCOCC5)cnc(N)c34)cc2)c1 CHEMBL1982465 pKi 3.162 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)c(F)c3)c12 CHEMBL2000652 pKi 3.162 nM
Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O CHEMBL477772 pKi 3.162 nM
Cn1cc(-c2ccc(Cn3cc(-c4ccccc4F)nn3)cc2)cn1 CHEMBL4469077 IC50 3.17 nM
CS(=O)(=O)c1ccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5ccccc5)cccc4c3)n2)cc1 CHEMBL3740554 IC50 3.2 nM
C(=C/c1n[nH]c2cc(Oc3ccccc3)ccc12)\c1ccccc1 CHEMBL3975092 Ki 3.2 nM
Cc1c(C(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cn2)c(=O)n(-c2ccccc2)n1C CHEMBL3703194 Kd 3.2 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)cc1)Nc1cccc(C(F)(F)F)c1 CHEMBL4852364 IC50 3.2 nM
O=C(Nc1ccc(Oc2cc(Nc3cccc(CN4CCCC4)c3)ncn2)cc1)Nc1cccc(C(F)(F)F)c1 CHEMBL4867760 IC50 3.2 nM
Cc1nc2ccccc2n(CC(=O)Nc2ccc(C(=O)NC(C)(C)C)cc2)c1=O CHEMBL5409221 IC50 3.2 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4cnn(C(C)C)c4)c(F)c3)ncnc2cc1OCc1ccccc1 CHEMBL5401823 IC50 3.27 nM
COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4Cl)cc3)cc2[nH]1 CHEMBL244286 IC50 3.3 nM
CC1(C)CC(NC(=O)c2cccc(-c3cc4nccc(Nc5cccc(O)c5)n4n3)c2)CC(C)(C)N1[O] CHEMBL1163016 IC50 3.3 nM
CO/N=C/c1c(N)ncnc1Oc1ccc(NC(=O)Nc2ccccc2F)c(Cl)c1 CHEMBL1681950 IC50 3.3 nM
Cc1ccc(NC(=O)c2cccc3cc(-c4cccc5[nH]nc(N)c45)ccc23)c(F)c1 CHEMBL3288509 IC50 3.3 nM
COCCOc1cc2ncnc(NC3=CC(=O)C(OCC#Cc4ccccc4)=CC3=O)c2cc1OC CHEMBL3706837 IC50 3.4 nM
COC(=O)Nc1cn2cc(Oc3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)ccc2n1 CHEMBL243915 IC50 3.4 nM
COc1ccc(NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]c(C)c(C(=O)O)c2C)cc1 CHEMBL1173174 IC50 3.4 nM
C[C@@H]1Oc2ccc(-c3csc(NC(=O)c4cccc(Cl)c4)n3)cc2NC1=O CHEMBL1290136 IC50 3.4 nM
CO/N=C/c1c(N)ncnc1Oc1ccc(NC(=O)Nc2nccs2)c(Cl)c1 CHEMBL1681943 IC50 3.4 nM
O=C(Nc1ccc(Oc2ncnc3cc(OCCCN4CCOCC4)c4c(c23)OCCO4)c(F)c1)Nc1cc(C(F)(F)F)ccc1F CHEMBL4516513 IC50 3.4 nM
O=C(CSc1nc2ccccc2n2cnnc12)Nc1ccc(C(=O)Nc2ccccc2)cc1 CHEMBL4877180 IC50 3.4 nM
O=C(Cn1c(=O)c2nncn2c2ccccc21)Nc1ccc(C(=O)Nc2ccc(Cl)cc2)cc1 CHEMBL5170911 IC50 3.4 nM
NC(=O)/C=C/c1ccc(COc2ccc(-n3cc4cccc(C(N)=O)c4n3)cc2)cc1 CHEMBL5208297 IC50 3.4 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=S)Nc4cc(Br)ccc4OC(F)(F)F)cc3)c12 CHEMBL4160854 IC50 3.45 nM
CN(C)CCOc1ccc(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)cc1F CHEMBL3633686 IC50 3.47 nM
COC(=O)Nc1nc2cc(Oc3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)ccc2[nH]1 CHEMBL396056 IC50 3.5 nM
O=C1CS/C(=N/Nc2nncc3ccccc23)N1c1ccccc1 CHEMBL3982619 IC50 3.5 nM
Nc1cccc(Nc2ccc3c(/C=C/c4ccccc4)n[nH]c3c2)c1 CHEMBL3893896 Ki 3.5 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 3.5 nM
COc1cc2ncnc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)c2c2c1OCCO2 CHEMBL5434391 IC50 3.5 nM
COc1cc(O)c2c(c1)-c1cccc(c1)[C@@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O CHEMBL4453304 IC50 3.56 nM
C#CC(OC1=CC(=O)C(Nc2ncnc3cc(OCCCN4CCCC4)c(OC)cc23)=CC1=O)c1ccccc1 CHEMBL3706816 IC50 3.6 nM
CN1CCN(Cc2cc(Nc3nc4cc(Oc5ccnc6ccccc56)ccc4o3)ccc2Cl)CC1 CHEMBL390175 Ki 3.6 nM
Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)sc4c3)c2)n(C)n1 CHEMBL2409790 IC50 3.6 nM
CCN1C(=O)CS/C1=N/Nc1nncc2ccccc12 CHEMBL3893698 IC50 3.6 nM
COc1cc(/C=C/C(=O)Nc2cc3c(Nc4ccc(F)c(Cl)c4)ncnc3cc2O[C@@H]2CCOC2)cc(OC)c1OC CHEMBL4466350 IC50 3.6 nM
COc1ccc(/C=C/C(=O)Nc2cc3c(Nc4ccc(F)c(Cl)c4)ncnc3cc2O[C@@H]2CCOC2)cc1 CHEMBL4439680 IC50 3.6 nM
COC(C)Oc1cc2ncnc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)c2c2c1OCCO2 CHEMBL5434570 IC50 3.6 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(Cl)c(Cl)c4)cc3)c2cc1OC CHEMBL359617 IC50 3.7 nM
COc1cc2c(NC3=CC(=O)C(OC(CF)CF)=CC3=O)ncnc2cc1OCC1CCN(C)CC1 CHEMBL3706826 IC50 3.7 nM
Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4ccc(F)c(C(F)(F)F)c4)cc3)cncc21 CHEMBL256824 IC50 3.7 nM
Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)c(Cl)c3)c21 CHEMBL1254190 IC50 3.7 nM
Cn1nc(C(F)(F)F)cc1C(=O)Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c1 CHEMBL2349012 IC50 3.7 nM
Cc1cc(C(=O)Nc2ccc(C)c(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)c2)n(C)n1 CHEMBL2409783 IC50 3.7 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5cccc(C(F)(F)F)c5)cccc4c3)n2)c1 CHEMBL3741916 IC50 3.7 nM
COc1cc(-c2ccc3c(-c4cc5ccccc5[nH]4)n[nH]c3c2)ccc1O CHEMBL3891392 Ki 3.7 nM
Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(Cl)ccc3O)cc12 CHEMBL4105329 IC50 3.7 nM
O=C(Nc1cccc(C(F)(F)F)c1)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1 CHEMBL3978551 IC50 3.73 nM
COc1cc(-c2cc(NC(=O)Nc3cc(OCCN4CCCCC4)ccc3C)cc(OC)c2OC)ccc1/C(C)=N/O CHEMBL3220327 IC50 3.77 nM
COCCOc1cc2ncnc(NC3=CC(=O)C=C(OC)C3=O)c2cc1OC CHEMBL2113183 IC50 3.8 nM
COc1cccc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(N)c34)cc2)c1 CHEMBL256043 IC50 3.8 nM
COc1cc2nccc(Oc3ccc4c(C(=O)NCC(F)(F)F)cccc4c3)c2cc1OC CHEMBL410840 IC50 3.8 nM
CNC(=O)c1cccc2cc(Oc3ccnc4cc(OC)c(OC)cc34)ccc12 CHEMBL270754 IC50 3.8 nM
Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4ccnc(C(F)(F)F)c4)c(Cl)c3)c21 CHEMBL1254278 IC50 3.8 nM
O=C(Nc1cccc2cccnc12)c1cc(Cl)ccc1O CHEMBL1271615 IC50 3.8 nM
Cc1[nH]c2c(c1C(=O)NCCCN1CCCC1)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430249 IC50 3.8 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1NC(=O)CCN1CCN(C)CC1 CHEMBL3288854 Ki 3.8 nM
Cc1ccc(F)c(NC(=O)c2cccc3cc(-c4cccc5[nH]nc(N)c45)ccc23)c1 CHEMBL3288508 IC50 3.8 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc4c(c3)OCCN4C(=O)Nc3ccccc3)n2)c1 CHEMBL3740163 IC50 3.8 nM
Cc1cc2c(F)c(Oc3cc(Nc4cccc(CS(C)(=O)=O)c4)ncn3)ccc2[nH]1 CHEMBL5184038 IC50 3.8 nM
COc1cc2nccc(Oc3ccc4c(C(=O)NCC(F)F)cccc4c3)c2cc1OC CHEMBL1242667 pIC50 3.802 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4ccc(F)cc4)c(F)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5419881 IC50 3.88 nM
COc1cc2c(NC3=CC(=O)C(OCCN(C)c4ccccc4)=CC3=O)ncnc2cc1OCC1CCN(C)CC1 CHEMBL2113184 IC50 3.9 nM
CNC(=O)c1cc(Oc2ccc3[nH]c(Nc4ccc(Cl)c(CN5CCN(C)CC5)c4)nc3c2)ccn1 CHEMBL413621 Ki 3.9 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(Br)cc21 CHEMBL2430265 IC50 3.9 nM
CCN(CC)CCOc1ccc(C)c(NC(=O)Nc2cc(OC)c(OC)c(-c3ccc(/C(C)=N/O)c(OC)c3)c2)c1 CHEMBL3220325 IC50 3.9 nM
Nc1n[nH]c2cccc(-c3ccc4c(C(=O)Nc5cccc(Br)c5)cccc4c3)c12 CHEMBL3288517 IC50 3.9 nM
O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1F CHEMBL3894725 IC50 3.9 nM
O=C(CSc1nc2ccccc2n2cnnc12)Nc1ccc(C(=O)Nc2ccc(Cl)cn2)cc1 CHEMBL4849165 IC50 3.9 nM
Cc1cccc(NC(=O)c2ccc(NC(=O)Cn3c(=O)c4nncn4c4ccccc43)cc2)c1 CHEMBL4861773 IC50 3.9 nM
Cc1ccc(O)c(NC(=O)c2ccc(NC(=O)Cn3c(=O)c4nncn4c4ccccc43)cc2)c1 CHEMBL5175388 IC50 3.9 nM
O=C(Nc1ccc(Cl)cc1)c1cccc2cc(Oc3ccnc4ccccc34)ccc12 CHEMBL273064 pIC50 3.981 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCCCCCCCCN)cnc(N)c34)cc2)c1 CHEMBL1978166 pKi 3.981 nM
CNC(=O)c1ccccc1Sc1ccc2c(C=Cc3ccccn3)n[nH]c2c1 CHEMBL1988437 pKi 3.981 nM
CCOc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)cc1 CHEMBL1974254 pKi 3.981 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)cc1 CHEMBL1982466 pKi 3.981 nM
Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c12 CHEMBL1976220 pKi 3.981 nM
CCCn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1993941 pKi 3.981 nM
O=C(O)CCc1c(/C=C2\C(=O)Nc3ccc(C(=O)O)cc32)[nH]c2c1CCCC2 CHEMBL431996 IC50 4.0 nM
Oc1nc2ccccc2cc1-c1cc2cc(OCCN3CCCCC3)ccc2[nH]1 CHEMBL333297 IC50 4.0 nM
CC(=O)N1CCN(CCOc2ccc3[nH]c(-c4cc5ccccc5nc4O)cc3c2)CC1 CHEMBL119276 IC50 4.0 nM
c1cc(-c2cnn3cc(-c4ccc(OCCN5CCOCC5)cc4)cnc23)cs1 CHEMBL324335 IC50 4.0 nM
CCOCc1ccc2c(c1)c1c3c(c4c(c1n2CCCO)Cc1ccccc1-4)C(=O)NC3 CHEMBL424323 IC50 4.0 nM
COCCOc1cc2nncc(Nc3cc(O)c(Cl)cc3F)c2cc1OC CHEMBL150826 IC50 4.0 nM
Cc1ccc(Nc2ncnn3cc(OCCCN4CCCCC4)c(C(C)C)c23)cc1O CHEMBL369322 IC50 4.0 nM
CN1CCN(Cc2ccc(NC(=O)Nc3ccc(N(C)c4ccnc(Nc5ccc(CS(C)(=O)=O)cc5)n4)cc3)cc2)CC1 CHEMBL187627 IC50 4.0 nM
CCN(CC)CCCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(-c3cc(OC)cc(OC)c3)cc2cn1 CHEMBL192856 IC50 4.0 nM
CC1(C)O[C@@H](n2c3ccccc3c3c4c(c5c6ccccc6[nH]c5c32)CNC4=O)C[C@@]1(O)CO CHEMBL370493 IC50 4.0 nM
Nc1ncnc2snc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)c12 CHEMBL213504 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2C)cc1-c1ccc2nc(Nc3ccccc3)ncc2c1 CHEMBL215863 IC50 4.0 nM
CCCn1c2ccc(NC(=O)c3cccs3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL220406 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1ncccc1-c1ccncn1 CHEMBL385956 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1C#Cc1cnc2ccccc2n1 CHEMBL221019 IC50 4.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cccnc5)cnc(N)c34)cc2)c1 CHEMBL427267 IC50 4.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5ccncc5)cnc(N)c34)cc2)c1 CHEMBL268826 IC50 4.0 nM
O=C(O)CCC1CCCc2[nH]c(/C=C3\C(=O)Nc4ccc(C(=O)O)cc43)cc21 CHEMBL231139 IC50 4.0 nM
CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(Cl)c(CN5CCOCC5)c4)nc3c2)ccn1 CHEMBL231570 Ki 4.0 nM
CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(Cl)c(OCCN(C)C)c4)nc3c2)ccn1 CHEMBL231569 Ki 4.0 nM
CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(Cl)c(CN5CCN(C)CC5)c4)nc3c2)ccn1 CHEMBL231469 Ki 4.0 nM
O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)c1cccnc1NCc1ccncc1 CHEMBL250684 Ki 4.0 nM
CCO/N=C(\C)c1ccc2c(c1)c1c3c(c4c(c1n2C(C)C)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL401896 IC50 4.0 nM
CCO/N=C(\C)c1ccc2c(c1)c1c3c(c4c(c1n2CC(C)C)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL428433 IC50 4.0 nM
CO/N=C(\C)c1ccc2c(c1)c1c3c(c4c(c1n2C(C)C)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL401876 IC50 4.0 nM
CCn1c2ccc(/C(C)=N/OC)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL255283 IC50 4.0 nM
CO/N=C(/c1ccc2[nH]c3c4c(c5c(c3c2c1)CNC5=O)-c1cn(C)nc1CC4)C(C)C CHEMBL257793 IC50 4.0 nM
CCO/N=C/c1ccc2[nH]c3c4c(c5c(c3c2c1)CNC5=O)-c1cn(C)nc1CC4 CHEMBL257788 IC50 4.0 nM
C/C(=N\OC(C)C)c1ccc2c(c1)c1c3c(c4c(c1n2C(C)C)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL429138 IC50 4.0 nM
C/C(=N\OC(C)C)c1ccc2c(c1)c1c3c(c4c(c1n2CC(C)C)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL403823 IC50 4.0 nM
CO/N=C(\C)c1ccc2c(c1)c1c3c(c4c(c1n2CC(C)C)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL258015 IC50 4.0 nM
C/C(=N\OCC(C)C)c1ccc2[nH]c3c4c(c5c(c3c2c1)CNC5=O)-c1cn(C)nc1CC4 CHEMBL258433 IC50 4.0 nM
Nc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL404223 IC50 4.0 nM
COc1cc(Nc2ncnc(-n3c(Nc4c(C)cccc4C)nc4ccccc43)n2)cc(OC)c1OC CHEMBL270692 IC50 4.0 nM
CC(C)Cn1c2ccc(C(=O)c3ccco3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL410100 IC50 4.0 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)cc1)CCN2 CHEMBL411903 IC50 4.0 nM
Cn1cc(-c2ccn3c(N)c(-c4ccc(NC(=O)Nc5cccc(Cl)c5)cc4)cnc23)cn1 CHEMBL453058 IC50 4.0 nM
O=C(Nc1cccc(C(F)(F)F)c1)c1cccc2c1CCN(Cc1ccnc3ccccc13)C2 CHEMBL495089 IC50 4.0 nM
O=C(CC(=O)Nc1ccc(Oc2ccnc3cc(C(=O)N4CCCC4)sc23)c(F)c1)Nc1ccccc1 CHEMBL566010 IC50 4.0 nM
Cc1ccc(NC(=O)c2ccc(C(C)(C)C)s2)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 CHEMBL1086731 IC50 4.0 nM
Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cnn(CC(F)(F)F)c4)c(Cl)c3)c21 CHEMBL1254355 IC50 4.0 nM
O=C(Nc1cccc(C(F)(F)F)c1)Nc1ccc(Oc2ncnc3ccn(CCO)c23)cc1Cl CHEMBL1253916 IC50 4.0 nM
c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)ccn1 CHEMBL478629 IC50 4.0 nM
CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL2010872 IC50 4.0 nM
COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)c(C)c3)c2cc1OC CHEMBL2018884 IC50 4.0 nM
Nc1ncc(-c2cnn(CCN3CCCCC3)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL2022854 IC50 4.0 nM
CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)n[nH]1 CHEMBL2023486 IC50 4.0 nM
Cc1cn2c(-c3cn[nH]c3)cnc2c(Nc2cc(CN3CCCCC3)ns2)n1 CHEMBL1739550 IC50 4.0 nM
O=C1Nc2ccc(C(=O)O)cc2C1=C(c1ccccc1)c1nc2ccccc2[nH]1 CHEMBL2086736 IC50 4.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2cc(F)cc(F)c2)c2nc4ccccc4[nH]2)C(=O)N3)CC1 CHEMBL2086757 IC50 4.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2ccc(Cl)cc2)c2ncc[nH]2)C(=O)N3)CC1 CHEMBL2086760 IC50 4.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2cccc(F)c2)c2nc(C)c[nH]2)C(=O)N3)CC1 CHEMBL2087167 IC50 4.0 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)c(F)c3)n2)c1 CHEMBL3287309 IC50 4.0 nM
CC(C)n1c(Nc2ccc(Br)cc2)nc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc21 CHEMBL3678950 IC50 4.0 nM
O=C(Nc1cccc(C(F)(F)F)c1)n1ccc2cc(Oc3cc(CO)ncn3)ccc21 CHEMBL3746595 IC50 4.0 nM
C[C@H]1Cc2c(ncnc2Oc2ccc3c(ccn3C(=O)Nc3cc(C(C)(C)C)on3)c2)CN1 CHEMBL3747669 IC50 4.0 nM
O=C(N=S(=O)(CCCO)CCCO)c1cncc(C#Cc2cccc(NC(=O)c3cccc(C(F)(F)F)c3)c2)c1 CHEMBL3983941 IC50 4.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3cccc(C(F)(F)F)c3)c2)c1 CHEMBL3920861 IC50 4.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3ccc(Cl)c(C(F)(F)F)c3)c2)c1 CHEMBL3963696 IC50 4.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)Nc3cccc(C)c3)c2)c1 CHEMBL3925180 IC50 4.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3ccc(OC)c(OC)c3)c2)c1 CHEMBL3957336 IC50 4.0 nM
COC(=O)C1CCCN1CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1 CHEMBL3978824 IC50 4.0 nM
COC(=O)CC[C@H](NC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1)C(=O)OC CHEMBL3933714 IC50 4.0 nM
CCOC(=O)CN1CCN(CCCNC(=O)c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)ccc5F)cc4)c3s2)CC1 CHEMBL3917483 IC50 4.0 nM
COC(=O)[C@@H]1C[C@@H](O)CN1CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1 CHEMBL4107173 IC50 4.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(C(=O)NCCN)sc34)cc2F)c1 CHEMBL3951242 IC50 4.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(C(=O)NCCCN5CCCCC5)sc34)cc2)c1 CHEMBL3926026 IC50 4.0 nM
CCN(CC)CCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1 CHEMBL3961927 IC50 4.0 nM
COc1cc2ncnc(-n3nc(Nc4ccc(OC5CCCN(C)C5)cc4)nc3N)c2cc1OC CHEMBL4098219 EC50 4.0 nM
CN1CCN(CC(=O)N(C)c2ccc(N/C(=C3\C(=O)Nc4cc(-c5nnco5)ccc43)c3ccccc3)cc2)CC1 CHEMBL4160821 IC50 4.0 nM
COc1cccc(NC(=O)Nc2ccc(Oc3ncnc4cc(OC)c5c(c34)OCCO5)cc2)c1 CHEMBL4531859 IC50 4.0 nM
CN1CCN(Cc2ccc(NC(=O)CC(=O)Nc3ccc4c(/C=C/c5ccccn5)n[nH]c4c3)cc2C(F)(F)F)CC1 CHEMBL4799880 GI50 4.0 nM
Cc1nc(NC(=O)Nc2cccc(C(F)(F)F)c2)sc1-c1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL4788370 GI50 4.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)ccn1 CHEMBL1992306 IC50 4.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1 CHEMBL1946170 IC50 4.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)NC5CC5)CC4)c(Cl)c3)c2cc1C(N)=O CHEMBL5201128 IC50 4.0 nM
COC(=O)Nc1nccc(Oc2ccc3c(C(=O)Nc4ccc(F)c(C(F)(F)F)c4)cccc3c2)n1 CHEMBL5268513 IC50 4.0 nM
Nc1nccc(Oc2ccc3c(C(=O)Nc4ccc(F)c(C(F)(F)F)c4)cccc3c2)n1 CHEMBL5276611 IC50 4.0 nM
COc1cc(-c2cc(NC(=O)Nc3ccc(OCCCN4CCOCC4)cc3)cc(OC)c2OC)ccc1C(C)=O CHEMBL3099462 IC50 4.06 nM
COc1cc(-c2cc(NC(=O)Nc3ccc(OCCN4CCCC4)cc3)cc(OC)c2OC)ccc1/C(C)=N/O CHEMBL3220321 IC50 4.08 nM
Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c21 CHEMBL1254670 IC50 4.1 nM
CCOc1ccc(Nc2cnnc(Nc3ccc(OCC)cc3)n2)cc1 CHEMBL1290137 IC50 4.1 nM
O=C(Nc1ccc(Oc2ncnc3sc4c(c23)CCCC4)cc1)c1ccccc1 CHEMBL1290031 IC50 4.1 nM
CNS(=O)(=O)c1cccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5ccccc5)cccc4c3)n2)c1 CHEMBL3741621 IC50 4.1 nM
O=C(Nc1cc(C2CC2)on1)n1ccc2cc(Oc3ncnc4c3CSC4)ccc21 CHEMBL4084937 IC50 4.1 nM
Cc1c(C(=O)NCCCN(C)C)cn2ncnc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)c12 CHEMBL4292884 IC50 4.1 nM
Cn1cc(-c2ccc(Cn3cc(-c4cccc(NC(=O)C5CC5)c4)nn3)cc2)cn1 CHEMBL4539395 IC50 4.15 nM
COCCCNC(=O)c1cccc2cc(Oc3ccnc4cc(OC)c(OC)cc34)ccc12 CHEMBL271189 pIC50 4.169 nM
COc1cc2c(NC3=CC(=O)C(OCc4ccco4)=CC3=O)ncnc2cc1OCCCN1CCCC1 CHEMBL2113163 IC50 4.2 nM
Nc1ncc(-c2cccc(S(N)(=O)=O)c2)c2occ(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL241682 IC50 4.2 nM
Cc1ccc2nc(NC(=O)Cc3csc(NC(=O)Nc4cccc(Cl)c4)n3)sc2c1 CHEMBL1290471 IC50 4.2 nM
O=C(Nc1ccc(Oc2cc(NC(=O)C3CC3)ncn2)nc1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL3946883 IC50 4.2 nM
CC1CN(c2cc(NC(=O)Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)c(F)c3)cc(C(F)(F)F)c2)C(=O)O1 CHEMBL3909183 IC50 4.2 nM
CC(C)Oc1cc2ncnc(Oc3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c2c2c1OCCO2 CHEMBL4435366 IC50 4.2 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1cccn(-c2ccc(F)cc2)c1=O CHEMBL509101 IC50 4.27 nM
Nc1ncnc2c1c(-c1ccc(Cl)c(O)c1)nn2C1CCCC1 CHEMBL1241676 IC50 4.3 nM
O=C(CN1CCOCC1)N1CCc2nc(-c3cc4cc(F)ccc4[nH]c3=O)[nH]c2C1 CHEMBL2016909 IC50 4.3 nM
Cc1[nH]c2c(c1C(=O)NCCN1CCCCC1)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430259 IC50 4.3 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL3947363 IC50 4.3 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cncc4[nH]nc(N)c34)c3ccccc23)c1 CHEMBL3920239 IC50 4.3 nM
COc1ccc(C(=O)Nc2ccc(OCCN3CCCCC3)cc2)c(-c2cccc(O)c2)c1O CHEMBL3397917 IC50 4.38 nM
COCCOc1cc2ncnc(NC3=CC(=O)C(Cl)=CC3=O)c2cc1OC CHEMBL2113166 IC50 4.4 nM
Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c21 CHEMBL1254835 IC50 4.4 nM
O=C1CS/C(=N/Nc2nncc3ccccc23)N1 CHEMBL3938794 IC50 4.4 nM
COCCOc1cc2ncnc(NC3=CC(=O)C(OCC(F)F)=CC3=O)c2cc1OC CHEMBL3706835 IC50 4.5 nM
COc1cc2c(NC3=CC(=O)C(OCc4c(F)c(F)c(F)c(F)c4F)=CC3=O)ncnc2cc1OCCCN1CCCC1 CHEMBL3706841 IC50 4.5 nM
Cc1ccc(NC(=O)c2cccc3cc(-c4cccc5[nH]nc(N)c45)ccc23)cc1F CHEMBL3288510 IC50 4.5 nM
CCCCNC(=S)NNc1nncc2ccccc12 CHEMBL3905411 IC50 4.5 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1)Nc1ccc2c(c1)C(F)(F)CCO2 CHEMBL3969197 IC50 4.5 nM
COc1cc(-c2cc(NC(=O)Nc3ccc(OCCCN(C)C)cc3C)cc(OC)c2OC)ccc1C(C)=O CHEMBL3099465 IC50 4.55 nM
COCCOc1cc2ncnc(NC3=CC(=O)C(OC(c4ccccc4)C(F)(F)F)=CC3=O)c2cc1OC CHEMBL2113188 IC50 4.6 nM
O=C(Nc1ccc(-c2cccnc2)cc1)Nc1ccc(OC(F)(F)F)cc1Br CHEMBL3586051 IC50 4.6 nM
Oc1cccc(Nc2ccnc3cc(-c4cccc(CN5CCOCC5)c4)sc23)c1 CHEMBL2336005 IC50 4.6 nM
C=C(c1cccc(N)c1)c1ccc2c(/C=C/c3ccccc3)n[nH]c2c1 CHEMBL3930504 Ki 4.6 nM
CS(=O)(=O)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)nc2)cc(C(F)(F)F)c1 CHEMBL3958722 IC50 4.6 nM
CN1CCN(CC(=O)N(C)c2ccc(N/C(=C3\C(=O)Nc4cc(-c5ncon5)ccc43)c3ccccc3)cc2)CC1 CHEMBL4165331 IC50 4.6 nM
O=C(CSc1nc2ccccc2n2cnnc12)Nc1ccc(C(=O)Nc2ccccn2)cc1 CHEMBL4856747 IC50 4.6 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(S(=O)(=O)NCCN4CCCC4)cc3)nc12 CHEMBL249821 IC50 4.7 nM
COc1ccc(NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]c(C)c(CC(=O)O)c2C)cc1 CHEMBL1173150 IC50 4.7 nM
Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c2C)n(C)n1 CHEMBL2348993 IC50 4.7 nM
O=C(Nc1cccc(C(=O)c2ccc3c(/C=C/c4ccccc4)n[nH]c3c2)c1)c1ccncc1 CHEMBL3949835 Ki 4.7 nM
O=C(Cn1c(=O)c2nncn2c2ccccc21)Nc1ccc(C(=O)NCc2ccccc2)cc1 CHEMBL4863157 IC50 4.7 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5401089 IC50 4.74 nM
C#CCOC1=CC(=O)C(Nc2ncnc3cc(OCCCN4CCCC4)c(OC)cc23)=CC1=O CHEMBL3706817 IC50 4.8 nM
COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)cc2o1 CHEMBL243914 IC50 4.8 nM
O=C(Cn1c(=O)c2nncn2c2ccccc21)Nc1ccc(C(=O)Nc2cc(Cl)ccc2Cl)cc1 CHEMBL5202279 IC50 4.8 nM
O=C(Nc1ccc(OCCN2CCCC2)c(F)c1)c1cccc(-c2cccc(O)c2)c1 CHEMBL3397935 IC50 4.86 nM
O=C(c1ccc(CN2CCCCC2)cc1)N1CCc2nc(-c3cc4cc(F)ccc4[nH]c3=O)[nH]c2C1 CHEMBL2016905 IC50 4.9 nM
COc1cc(Nc2nccc(Oc3ccc4c(C(=O)Nc5ccccc5)cccc4c3)n2)cc(OC)c1 CHEMBL3739726 IC50 4.9 nM
O=C(Nc1cccc(OC(F)(F)F)c1)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1 CHEMBL3959341 IC50 4.9 nM
CN1CCN(CC(=O)N(C)c2ccc(N/C(=C3\C(=O)Nc4cc(-c5nnn(C)n5)ccc43)c3ccccc3)cc2)CC1 CHEMBL4175951 IC50 4.9 nM
COc1ccc(Nc2cc(Oc3ccc4[nH]c(C)cc4c3F)ncn2)cc1OC CHEMBL5183413 IC50 4.9 nM
CN1CCN(C(=O)c2ccc3[nH]c(-c4cc5ccccc5nc4O)cc3c2)CC1 CHEMBL324489 IC50 5.0 nM
NC1CCN(C(=O)c2ccc3[nH]c(-c4cc5ccccc5nc4O)cc3c2)C1 CHEMBL117052 IC50 5.0 nM
O=C(c1ccc2[nH]c(-c3cc4ccccc4nc3O)cc2c1)N1CCNCC1 CHEMBL119552 IC50 5.0 nM
COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OC[C@@H]1CCCN(C)C1 CHEMBL1907763 IC50 5.0 nM
Cc1cc(Nc2nccc(-n3ccnc3-c3ccccc3)n2)cc(C(F)(F)F)c1 CHEMBL44915 IC50 5.0 nM
COc1cc(Nc2nccc(-n3ccnc3-c3ccccc3)n2)cc(OC)c1 CHEMBL47852 IC50 5.0 nM
Cc1ccc(Nc2ncnn3cc(NC(=O)OCCCN4CCCCC4)c(C(C)C)c23)cc1O CHEMBL178607 IC50 5.0 nM
Cc1ccc(Nc2ncnn3cc(NC(=O)NCCCN4CCCCC4)c(C(C)C)c23)cc1O CHEMBL360118 IC50 5.0 nM
CN(c1ccc(NC(=O)Nc2ccccc2)cc1)c1ccnc(Nc2cccc(S(N)(=O)=O)c2)n1 CHEMBL2096808 IC50 5.0 nM
COc1cc(OC)cc(-c2cc3cnc(NCCCN4CCN(C)CC4)cc3nc2NC(=O)NC(C)(C)C)c1 CHEMBL189995 IC50 5.0 nM
COc1cc(OC)cc(-c2cc3cnc(NCCCO)cc3nc2NC(=O)NC(C)(C)C)c1 CHEMBL278472 IC50 5.0 nM
COC1=CC(=O)C(Nc2ncnc3cc(OCC4CCN(C)CC4)c(OC)cc23)=CC1=O CHEMBL200723 IC50 5.0 nM
CCc1cccc(NC(=O)Nc2ccc(-c3nsc4ncnc(N)c34)cc2)c1 CHEMBL445570 IC50 5.0 nM
CNc1ncc2cc(-c3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)ccc2n1 CHEMBL212128 IC50 5.0 nM
CCCn1c2ccc(NC(=O)OC(C)C)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL219492 IC50 5.0 nM
CC(C)Cn1c2ccc(NC(=O)c3ccco3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL219080 IC50 5.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3ccc(F)c4[nH]nc(N)c34)cc2)c1 CHEMBL374752 IC50 5.0 nM
COCCOCC#Cc1cc(-c2n[nH]c3c2Cc2ccc(Cn4cncn4)cc2-3)cs1 CHEMBL223971 IC50 5.0 nM
CN1CCN(CCc2ccc3c(c2)Cc2c(-c4csc(C#CCOc5ccccc5)c4)n[nH]c2-3)CC1 CHEMBL390353 IC50 5.0 nM
CCN(CC)CCOc1cc(Nc2nc3cc(Oc4ccnc(C(=O)NC)c4)ccc3o2)ccc1Cl CHEMBL395335 Ki 5.0 nM
COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)cc2[nH]1 CHEMBL244079 IC50 5.0 nM
CNc1cc(-c2cccnc2Oc2cc(C(=O)Nc3cccc(C(C)C)c3)ccc2C)ccn1 CHEMBL245745 IC50 5.0 nM
CO/N=C(\C)c1ccc2c(c1)c1c3c(c4c(c1n2C)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL255282 IC50 5.0 nM
Nc1noc2cccc(-c3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c12 CHEMBL272802 IC50 5.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4onc(N)c34)cc2)c1 CHEMBL410130 IC50 5.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1C(=O)Nc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1 CHEMBL408070 IC50 5.0 nM
COc1cc2nccc(Oc3ccc4c(C(=O)NC(C)C)cccc4c3)c2cc1OC CHEMBL408211 IC50 5.0 nM
CCCn1c2ccc(C(=O)c3cccs3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL255959 IC50 5.0 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3ccc(F)c(C(F)(F)F)c3)cc1)CCN2 CHEMBL429516 IC50 5.0 nM
COc1cc2nccc(Oc3ccc4c(NC(=O)c5ccc(Cl)cc5)nn(C)c4c3)c2cc1OC CHEMBL462563 IC50 5.0 nM
CN1CCCC(Oc2cccc3[nH]c(=O)c(-c4nc5ccccc5[nH]4)c(N)c23)C1 CHEMBL495749 IC50 5.0 nM
Cn1cc(-c2ccn3c(N)c(-c4ccc(NC(=O)Nc5cc(C(F)(F)F)ccc5F)cc4)cnc23)cn1 CHEMBL512839 IC50 5.0 nM
CCn1cnc(C(=O)c2cc3nccc(Oc4ccc(NC(=O)CC(=O)Nc5ccccc5)cc4F)c3s2)c1 CHEMBL565990 IC50 5.0 nM
CCn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)CC(=O)Nc5ccc(F)cc5)cc4F)c3s2)c1 CHEMBL567475 IC50 5.0 nM
CCN1CCN(c2cc(C(=O)Nc3ccc(C)c(Nc4nc5ccccc5n4-c4cc(N)ncn4)c3)cc(C(F)(F)F)c2)CC1 CHEMBL1076437 IC50 5.0 nM
Cn1cc2c(n1)CCc1c-2c2c(c3c1[nH]c1ccc(C4CCCCO4)cc13)CNC2=O CHEMBL1082503 IC50 5.0 nM
O=C(COc1cccc(NC(=O)c2cccnc2)c1)Nc1ccc(Br)cc1 CHEMBL1290247 IC50 5.0 nM
Cc1cc2c(F)c(Oc3ncnn4cc(OC[C@@H](C)O)c(C)c34)ccc2[nH]1 CHEMBL377300 Kd 5.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1sccc1NCc1ccnc2ccccc12 CHEMBL1614710 IC50 5.0 nM
Cc1ccc(C(=C2C(=O)Nc3ccc(C(=O)O)cc32)c2nc3ccccc3[nH]2)cc1 CHEMBL2086740 IC50 5.0 nM
COc1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCN(C(=O)N1CCOCC1)C3)C(=O)N2 CHEMBL2403370 IC50 5.0 nM
CCNC(=O)c1c[nH]c(-c2cc(Oc3ccc(NC(=O)Nc4cccc(C)c4)cc3)ccn2)c1 CHEMBL3656114 IC50 5.0 nM
CNCc1cc(Oc2ccc3c(ccn3C(=O)Nc3ccc(F)c(C(F)(F)F)c3)c2)ncn1 CHEMBL3746204 IC50 5.0 nM
NC1CCN(c2ccc(-c3ccn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)cn2)CC1 CHEMBL3694719 IC50 5.0 nM
CCc1cccc(NC(=O)c2cccc(N3CCc4c(cnc5ccsc45)C3)c2)c1 CHEMBL3966912 IC50 5.0 nM
Cc1ccoc1C(=O)Nc1cccc(C#Cc2cncc(C(=O)N=S(=O)(CCCO)CCCO)c2)c1 CHEMBL3896486 IC50 5.0 nM
O=C(N=S(=O)(CCCO)CCCO)c1cncc(C#Cc2cccc(NC(=O)c3ccc(F)c(Cl)c3)c2)c1 CHEMBL3924066 IC50 5.0 nM
COc1cccc(C(=O)Nc2cccc(C#Cc3cc(C(=O)N=S(=O)(CCCO)CCCO)cnc3N)c2)c1 CHEMBL3918628 IC50 5.0 nM
Cc1ccoc1C(=O)Nc1cccc(C#Cc2cc(C(=O)N=S(C)(=O)CCCCC(=O)O)cnc2N)c1 CHEMBL3891572 IC50 5.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)Nc3cc(C)ccc3F)c2)c1 CHEMBL3915272 IC50 5.0 nM
Cc1ccoc1C(=O)Nc1cccc(C#Cc2cncc(C(=O)N=[S@](C)(=O)CCCO)c2)c1 CHEMBL4107561 IC50 5.0 nM
Cc1ccc(F)c(C(=O)Nc2cccc(C#Cc3cc(C(=O)N=S(C)(C)=O)cnc3N)c2)c1 CHEMBL3938643 IC50 5.0 nM
COc1ccc(Nc2ncc3c(n2)CCN(C(=O)c2cccnc2)C3)cc1 CHEMBL3952249 IC50 5.0 nM
COc1cc(Nc2ncc3c(n2)CCN(C(=O)c2cc(C)nn2C)C3)cc(OC)c1OC CHEMBL3976229 IC50 5.0 nM
COC(=O)CNCCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1 CHEMBL3979830 IC50 5.0 nM
COC(=O)CN(CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1)CC(=O)OC CHEMBL3972255 IC50 5.0 nM
COC(=O)C1CCN(C(=O)c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)ccc5F)c(F)c4)c3s2)C1 CHEMBL3966952 IC50 5.0 nM
CCOC(=O)CN1CCN(C(=O)CN2CCN(C(=O)c3cc4nccc(Oc5ccc(NC(=O)Nc6cc(C)ccc6F)c(F)c5)c4s3)CC2)CC1 CHEMBL3895671 IC50 5.0 nM
COC(=O)c1ccc2cc(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)n(C(N)=O)c2c1 CHEMBL3893131 IC50 5.0 nM
O=C(Nc1cc(-c2cccnc2)cc(C(F)(F)F)c1)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1 CHEMBL3944876 IC50 5.0 nM
O=C(Nc1cc(C2(C(F)(F)F)CC2)on1)n1ccc2cc(Oc3ncnc4c3CNC4)ccc21 CHEMBL4102438 IC50 5.0 nM
Cc1c(OCC(O)CN2CCN(C)CC2)cn2ncnc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)c12 CHEMBL4282387 IC50 5.0 nM
COCCNCc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)C5(C(=O)Nc6ccc(F)cc6)CC5)cc4F)c3s2)nc1 CHEMBL3989926 IC50 5.0 nM
COc1cc2ncnc(-n3ncc4cc(NC(=O)Nc5ccc(C)c(Cl)c5)ccc43)c2cc1OC CHEMBL4544826 IC50 5.0 nM
Cc1nc(NC(=O)c2cccc(C(F)(F)F)c2)sc1-c1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL4796859 GI50 5.0 nM
O=C(Nc1ccc(Oc2ccnc3ccccc23)cc1)Nc1cccc(C(F)(F)F)c1 CHEMBL4870490 IC50 5.0 nM
COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cnn(C)c1 CHEMBL5176837 IC50 5.0 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)(C)O)c5)cnc(N)c34)cc2)cc1 CHEMBL2004290 IC50 5.01 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL373798 pKi 5.012 nM
Cc1cccc(NC(=O)Nc2ccc(-c3coc4ncnc(N)c34)cc2)c1 CHEMBL1983963 pKi 5.012 nM
CNCC#Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL1964441 pKi 5.012 nM
Nc1ncnc2c1c(-c1cnc3[nH]ccc3c1)nn2C1CCCC1 CHEMBL1081312 pKi 5.012 nM
Cc1ccc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1988075 pKi 5.012 nM
Nc1ncc(-c2ccoc2)c2scc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)c12 CHEMBL1965570 pKi 5.012 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4c3CNC4=O)cc2C)c1 CHEMBL183844 pKi 5.012 nM
CC(C)(C(N)=O)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1967720 pKi 5.012 nM
CC(O)Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL2002165 pKi 5.012 nM
CCN(CC)CCNC(=O)C=Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL2004716 pKi 5.012 nM
Oc1cc(O)c2cc(O)c(-c3cc(O)c(O)c(O)c3)[o+]c2c1 CHEMBL590878 IC50 5.09 nM
O=C(Nc1ccc(Oc2ccc3[nH]c(NC(=O)c4ccco4)nc3c2)cc1)Nc1cc(C(F)(F)F)ccc1F CHEMBL244297 IC50 5.1 nM
CCc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)cc1NC(=O)c1cc(C)nn1C CHEMBL2348992 IC50 5.1 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cncc4[nH]nc(N)c34)c3ccccc23)c1 CHEMBL3951451 IC50 5.1 nM
COc1cccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5ccccc5)cccc4c3)n2)c1 CHEMBL3740530 IC50 5.2 nM
O=C(Nc1cc(N2CCC(O)CC2)cc(C(F)(F)F)c1)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1 CHEMBL3916992 IC50 5.2 nM
COc1cc(OC)cc(N(CCCN2CCC[C@H]2CNS(=O)(=O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3933000 pIC50 5.248 nM
COc1cc(-c2cc(NC(=O)Nc3ccc(OCCN4CCCCC4)cc3C)cc(OC)c2OC)ccc1C(C)=O CHEMBL3099466 IC50 5.26 nM
Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)c21 CHEMBL1254753 IC50 5.3 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1 CHEMBL3906129 IC50 5.3 nM
COCCOCC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)cc2[nH]1 CHEMBL244106 IC50 5.4 nM
COC(=O)Nc1nc2ncc(Oc3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)cc2[nH]1 CHEMBL387604 IC50 5.4 nM
COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cccc(SC)c4)cc3)cc2[nH]1 CHEMBL244096 IC50 5.4 nM
O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)Nc1cc(Oc2cc(NC(=O)C3CC3)ncn2)ccc1F CHEMBL3908050 IC50 5.4 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1)Nc1cc(C(F)(F)F)cc(N2CCOCC2)n1 CHEMBL3935348 IC50 5.4 nM
O=C(Nc1cccc2cccnc12)c1cc(Br)cnc1O CHEMBL1271667 IC50 5.5 nM
CN1CCC(COc2ccc3c(Nc4ccc(NC(=O)Nc5cccc(F)c5)cc4)ncnc3c2)CC1 CHEMBL1934327 IC50 5.5 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1)Nc1ccc(Cl)c(OC(F)(F)F)c1 CHEMBL3970244 IC50 5.5 nM
CS(=O)(=O)Nc1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(C(F)(F)F)c1 CHEMBL3943475 IC50 5.5 nM
O=C(Nc1cc(N2CC(F)(F)C2)cc(C(F)(F)F)c1)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1F CHEMBL3896385 IC50 5.5 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(F)c(C#Cc4cncc5ccccc45)c3)cc2C(F)(F)F)CC1 CHEMBL4086643 IC50 5.5 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(C(=O)Nc5ccc(Br)cc5OC(F)(F)F)CC4)cc3)c12 CHEMBL4104599 IC50 5.58 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc([N+](=O)[O-])cc4)cc3)c2cc1OC CHEMBL178568 IC50 5.6 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(Cl)cc4Cl)cc3)c2cc1OC CHEMBL179422 IC50 5.6 nM
Cc1c2ccc(N(C)c3ccnc(Nc4cccc(S(N)(=O)=O)c4)n3)cc2nn1C CHEMBL1794074 IC50 5.6 nM
NC(=O)c1cc(-c2ccccc2)sc1NC(=O)c1ccc(OC(F)F)cc1 CHEMBL1290470 IC50 5.6 nM
Cn1cc(C(=O)Nc2ccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c(F)c2)c(=O)n1-c1ccccc1 CHEMBL3093585 IC50 5.6 nM
COc1cccc(NC(=O)C2(C(=O)Nc3ccc(Oc4ccnc(Nc5cccc(CS(C)(=O)=O)c5)n4)c(F)c3)CC2)c1 CHEMBL3287313 IC50 5.6 nM
CC(F)(F)c1cncc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2F)c1 CHEMBL3956594 IC50 5.6 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1)Nc1cc(C(F)(F)F)ncn1 CHEMBL3913927 IC50 5.6 nM
COCCOc1cc2ncnc(NC3=CC(=O)C(OC(CF)CF)=C(OC)C3=O)c2cc1OC CHEMBL2113192 IC50 5.7 nM
Cc1cc(NC(=O)c2cccc3cc(-c4cccc5[nH]nc(N)c45)ccc23)no1 CHEMBL3288520 IC50 5.7 nM
COc1ccc(NC(=S)NNc2nncc3ccccc23)cc1 CHEMBL3927914 IC50 5.7 nM
O=C(Nc1ccc(Oc2cc(NC(=O)C3CC3)ncn2)cc1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL3949308 IC50 5.7 nM
O=C(Nc1ccc(Oc2cc(NC(=O)C3CC3)ncn2)c(F)c1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL3952636 IC50 5.7 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1)Nc1cc(OC(F)(F)F)ccc1F CHEMBL3922912 IC50 5.7 nM
Cc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1cc(F)cc(C(C)(F)F)c1 CHEMBL3896185 IC50 5.7 nM
COc1cc(-c2cc(NC(=O)Nc3ccc(OCCN(C)C)cc3)cc(OC)c2OC)ccc1/C(C)=N/O CHEMBL3220317 IC50 5.77 nM
COCCOc1cc2ncnc(NC3=CC(=O)C(Oc4ccc(-n5ccnc5)cc4)=CC3=O)c2cc1OC CHEMBL2113186 IC50 5.8 nM
COCCOc1cc2ncnc(NC3=CC(=O)C(OCc4c(F)c(F)c(F)c(F)c4F)=CC3=O)c2cc1OC CHEMBL3706840 IC50 5.8 nM
COc1cc(O)c2c(c1)CCC[C@H](O)CC(=O)/C=C\C[C@H](C)OC2=O CHEMBL1651521 IC50 5.8 nM
Cc1nc(N(C)c2ccc3occc3c2)c2cc(C)oc2n1 CHEMBL3403514 IC50 5.8 nM
C[C@@H](Oc1ccc2[nH]nc(/C=C/c3cnn(CCO)c3)c2c1)c1c(Cl)cncc1Cl CHEMBL3828009 IC50 5.8 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)nc1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL3952726 IC50 5.8 nM
O=C(Nc1cccc(C(F)(F)F)c1)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cn1 CHEMBL3970862 IC50 5.8 nM
CNCc1cc(Oc2ccc3c(ccn3C(=O)Nc3cc(C4(C(F)(F)F)CC4)on3)c2)ncn1 CHEMBL4087814 IC50 5.8 nM
COc1ccc(NC(=O)Nc2ccc(Sc3ccnc4cc(OC)c(OC)cc34)cc2)cc1 CHEMBL362486 IC50 5.9 nM
COc1ccc(OC)c(NC(=O)c2ccc(CSc3ncnc4[nH]cnc34)cc2)c1 CHEMBL1290246 IC50 5.9 nM
O=C(Nc1cccc(C(=O)c2ccc3c(/C=C/c4ccccc4)n[nH]c3c2)c1)OCc1ccccc1 CHEMBL3944638 Ki 5.9 nM
CC(C)C(=O)Nc1cccc(C(=O)c2ccc3c(/C=C/c4ccccc4)n[nH]c3c2)c1 CHEMBL3897763 Ki 5.9 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1)Nc1cc(C(F)(F)F)ccc1Cl CHEMBL3961613 IC50 5.9 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(-c4ccc(NC)nc4)cc3)cc2C(F)(F)F)CC1 CHEMBL4205803 IC50 5.9 nM
NC(=O)c1ccc(COc2ccc(-n3cc4cccc(C(N)=O)c4n3)cc2)cc1 CHEMBL5177616 IC50 5.92 nM
Cc1ccnc(Nc2ncc(-c3ccccc3)s2)c1 CHEMBL319065 IC50 6.0 nM
c1ccc(-c2cnc(Nc3ccc(CN4CCCC4)cn3)s2)cc1 CHEMBL98475 IC50 6.0 nM
O=C(NC1CCNC1)c1ccc2[nH]c(-c3cc4ccccc4nc3O)cc2c1 CHEMBL325003 IC50 6.0 nM
COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCCN(C)c1ccncc1 CHEMBL25579 IC50 6.0 nM
COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCC1CCN(C)CC1 CHEMBL24979 IC50 6.0 nM
Cc1cc(C)cc(Nc2nccc(-n3ccnc3-c3ccccc3)n2)c1 CHEMBL45752 IC50 6.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(Cl)ccc4Cl)cc3)c2cc1OC CHEMBL369747 IC50 6.0 nM
CN(c1ccc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1)c1ccnc(Nc2cccc(CS(C)(=O)=O)c2)n1 CHEMBL187609 IC50 6.0 nM
COc1cc(OC)cc(-c2cc3cnc(NCCCCCO)cc3nc2NC(=O)NC(C)(C)C)c1 CHEMBL365727 IC50 6.0 nM
COc1cc(OC)cc(-c2cc3cnc(NCCCCN4CCOCC4)cc3nc2NC(=O)NC(C)(C)C)c1 CHEMBL187396 IC50 6.0 nM
CCN(CC)CCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(-c3cc(OC)cc(OC)c3)cc2cn1 CHEMBL191023 IC50 6.0 nM
COCCOc1cc2ncnc(NC3=CC(=O)C=CC3=O)c2cc1OC CHEMBL2113178 IC50 6.0 nM
Cn1cc(/C=C2\C(=O)NN=C2c2cnccn2)c2c(Br)cccc21 CHEMBL380915 IC50 6.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2C)cc1-c1ccc2nc(NC3CC3)ncc2c1 CHEMBL212181 IC50 6.0 nM
Nc1ncc(C#Cc2ccc(F)c(C(=O)Nc3cccc(C(F)(F)F)c3)c2)cn1 CHEMBL218631 IC50 6.0 nM
CCc1cccc(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL221053 IC50 6.0 nM
CN1CCN(Cc2ccc3c(c2)Cc2c(-c4csc(C#CCOc5ccccc5)c4)n[nH]c2-3)CC1 CHEMBL390156 IC50 6.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3c(C)sc4ncnc(N)c34)cc2)c1 CHEMBL537435 IC50 6.0 nM
COc1ccc2c(c(/C=C3\C(=O)NN=C3c3cnns3)cn2C)c1Br CHEMBL398460 IC50 6.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1ccc2nc(N)ncc2c1 CHEMBL429582 IC50 6.0 nM
CC(C)Cn1c2ccc(C(=O)c3cccs3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL444105 IC50 6.0 nM
Cc1ccc(C2=Nc3c(N)ncnc3NCC2)cc1NC(=O)Nc1cccc(C(F)(F)F)c1 CHEMBL403706 IC50 6.0 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc1)CCN2 CHEMBL412102 IC50 6.0 nM
Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccccc5)cc4F)c3s2)c1 CHEMBL254760 IC50 6.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)Cn2ccnc2)cc1)c1ccccc1 CHEMBL524453 IC50 6.0 nM
Cn1cc(-c2ccn3c(N)c(-c4ccc(NC(=O)Nc5ccc(F)c(C(F)(F)F)c5)cc4)cnc23)cn1 CHEMBL469455 IC50 6.0 nM
CN(C)CCn1cnc(C(=O)c2cc3nccc(Oc4ccc(NC(=O)CC(=O)Nc5ccccc5)cc4F)c3s2)c1 CHEMBL576504 IC50 6.0 nM
CCn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)CC(=O)Nc5ccccc5OC)cc4F)c3s2)c1 CHEMBL566844 IC50 6.0 nM
CCn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)CC(=O)N(C)c5ccccc5)cc4F)c3s2)c1 CHEMBL565782 IC50 6.0 nM
CCn1c2ccc(C3CCCCO3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL1083757 IC50 6.0 nM
CNC(=O)c1cc(COc2nnc(Nc3ccc(Cl)cc3)c3ccoc23)ccn1 CHEMBL2079588 IC50 6.0 nM
CCCn1c2ccc(Nc3ncccn3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL2010871 IC50 6.0 nM
COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c2cc1OC CHEMBL2018882 IC50 6.0 nM
COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccc(F)c(Cl)c4)c(C)c3)c2cc1OC CHEMBL2018885 IC50 6.0 nM
CNC(=O)/C=C/c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL2023220 IC50 6.0 nM
COc1ccccc1NC(=O)Nc1ccc(-c2csc3c(-c4cnn(C)c4)cnc(N)c23)cc1 CHEMBL2023230 IC50 6.0 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)cc1 CHEMBL2023231 IC50 6.0 nM
CN1CCC(n2cc(-c3cnc(N)c4c(-c5ccc(NC(=O)Nc6cccc(F)c6)cc5)csc34)cn2)C1=O CHEMBL2022855 IC50 6.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cnn(CCO)c3)ncc2Cl)[C@H]2C=C[C@@H]1C2 CHEMBL2071270 IC50 6.0 nM
CNC(=O)Cn1cc(Nc2ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)cn1 CHEMBL2071273 IC50 6.0 nM
Cn1cc(Nc2ncc(Br)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)cn1 CHEMBL2071201 IC50 6.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2ccccc2)c2nc4ccccc4[nH]2)C(=O)N3)CC1 CHEMBL2086753 IC50 6.0 nM
COc1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCN(C(=O)N1CCN(C)CC1)C3)C(=O)N2 CHEMBL2403369 IC50 6.0 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)n2)c1 CHEMBL3287310 IC50 6.0 nM
Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(-c4cc(C(N)=O)c[nH]4)c3)cc2)c1 CHEMBL3656115 IC50 6.0 nM
Cc1ccc(NC(=O)Nc2ccc(-c3nsc(NC(=O)NCCCC(=O)O)c3C(N)=O)cc2)cc1 CHEMBL3696083 IC50 6.0 nM
NC(=O)c1c(-c2ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)cc2)nsc1NC(=O)NCCCN1CCOCC1 CHEMBL3696075 IC50 6.0 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5cc(F)cc(F)c5)cccc4c3)n2)c1 CHEMBL3739569 IC50 6.0 nM
CC1(c2cc(NC(=O)n3ccc4cc(Oc5ncnc6c5CNC6)ccc43)no2)CC1 CHEMBL3746370 IC50 6.0 nM
CCc1cccc(NC(=O)c2cccc(N3CCc4c(cnc5ccccc45)C3)c2)c1 CHEMBL3911073 IC50 6.0 nM
Cn1ccnc1C(=O)Nc1cccc(C#Cc2cc(C(=O)N=S(C)(C)=O)cnc2N)c1 CHEMBL3910699 IC50 6.0 nM
Cc1ccc(NC(=O)Nc2cccc(C#Cc3cncc(C(=O)N=S(C)(C)=O)c3)c2)cc1 CHEMBL3910155 IC50 6.0 nM
COc1cc(Nc2ncc3c(n2)CCN(C(=O)c2occc2C)C3)cc(OC)c1OC CHEMBL3943535 IC50 6.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(C(=O)NCCc5nn[nH]n5)sc34)cc2)c1 CHEMBL3911718 IC50 6.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(C(=O)NCCCN5CCCC5)sc34)cc2)c1 CHEMBL3939959 IC50 6.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cc4ccccc4n3C(N)=O)cc2)c1 CHEMBL3944202 IC50 6.0 nM
CC(C)c1cccc(NC(=O)Nc2ccc(-c3cc4ccccc4n3C(N)=O)cc2)c1 CHEMBL3968343 IC50 6.0 nM
O=C(Nc1cccc(C(F)(F)F)c1)c1cccc(N2CCc3c(cnc4ccnn34)C2)c1 CHEMBL3940300 IC50 6.0 nM
O=C(Nc1cccc(N2CCc3c(cnc4ccnn34)C2)c1)c1cccc(C(F)(F)F)c1 CHEMBL3954328 IC50 6.0 nM
CN1CCN(c2ccc(NC(=O)c3cccc4cc(Oc5ccnc(N)n5)ccc34)cc2C(F)(F)F)CC1 CHEMBL5269027 IC50 6.0 nM
COc1ccc(NC(=O)C2(C(=O)Nc3ccc(Oc4ccnc(Nc5cccc(CS(C)(=O)=O)c5)n4)c(F)c3)CC2)cc1 CHEMBL3287312 IC50 6.1 nM
Nc1n[nH]c2cccc(-c3ccc4c(C(=O)Nc5ccccc5F)cccc4c3)c12 CHEMBL3288511 IC50 6.1 nM
S=C(NNc1nncc2ccccc12)Nc1ccc(Cl)cc1 CHEMBL3896476 IC50 6.1 nM
CN1CCC(Nc2cc(NC(=O)Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)nc3)cc(C(F)(F)F)c2)CC1 CHEMBL3983977 IC50 6.1 nM
Cc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1cc(OC(F)(F)F)ccc1F CHEMBL3915341 IC50 6.1 nM
Cc1c(OCC(O)CN2CCOCC2)cn2ncnc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)c12 CHEMBL4285792 IC50 6.1 nM
C=CC(=O)Nc1cccc(-c2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)n1 CHEMBL4165320 IC50 6.17 nM
CC(C)(N)c1cc(C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688861 IC50 6.2 nM
COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)c2cc1OC CHEMBL2031893 INH 6.2 nM
CS(=O)(=O)Cc1cccc(Nc2cc(Oc3ccc4c(C(=O)Nc5ccccc5)cccc4c3)ncn2)c1 CHEMBL3740781 IC50 6.2 nM
S=C(NNc1nncc2ccccc12)Nc1ccccc1 CHEMBL3924500 IC50 6.2 nM
CC1CN(c2cc(NC(=O)Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)c(F)c3)cc(C(F)(F)F)c2)CC(C)O1 CHEMBL3903645 IC50 6.2 nM
CC(F)(F)c1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)c1 CHEMBL3892248 IC50 6.2 nM
COc1cc2c(Oc3ccc(NC(=O)Nc4ccncc4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5405595 IC50 6.22 nM
Nc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cc(F)cc(F)c4)cc3)c12 CHEMBL258141 pIC50 6.299 nM
COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)cc2[nH]1 CHEMBL396283 IC50 6.3 nM
Cc1ccc(Nc2ccnc(Nc3cccc(Br)c3)n2)cc1O CHEMBL444138 IC50 6.3 nM
COc1cc(Nc2nccc(Nc3ccc4c(C)n[nH]c4c3)n2)cc(OC)c1OC CHEMBL479079 IC50 6.3 nM
Cc1c(C(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)c(=O)n(-c2ccccc2)n1C CHEMBL3703196 Kd 6.3 nM
CNc1cc(Oc2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)c(F)c2)ncn1 CHEMBL4863203 IC50 6.3 nM
CNC(=O)C=Cc1cnc(N)c2c(-c3ccc4sc(C)nc4c3)csc12 CHEMBL1968590 pKi 6.31 nM
CNC(=O)C(C)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(C)cc5)cc4)csc23)cn1 CHEMBL1970142 pKi 6.31 nM
Cc1cc2cc(-c3csc4c(-c5cccc(S(C)(=O)=O)c5)cnc(N)c34)ccc2[nH]1 CHEMBL1997822 pKi 6.31 nM
CNC(=O)C=Cc1cnc(N)c2c(-c3cc(F)c4[nH]c(C)cc4c3)csc12 CHEMBL2006778 pKi 6.31 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 6.31 nM
COc1cc2c(NC3=CC(=O)C(OC(CF)CF)=CC3=O)ncnc2cc1OCCCN1CCCC1 CHEMBL2113193 IC50 6.4 nM
CO/N=C/c1c(N)ncnc1Oc1ccc(NC(=O)NC2CCCCC2)c(Cl)c1 CHEMBL1681955 IC50 6.5 nM
Cc1cc2cc(-n3ncc(C(=O)c4cc5ccccc5[nH]4)c3N)ccc2[nH]1 CHEMBL3959997 IC50 6.5 nM
CC(F)(F)c1cncc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)c1 CHEMBL3941664 IC50 6.5 nM
CN1CCN(Cc2ccc(NC(=O)c3ccnc(C#Cc4cncc5ccccc45)c3)cc2C(F)(F)F)CC1 CHEMBL4092294 IC50 6.5 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(-n2c(C)ccc2CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL4644718 IC50 6.5 nM
CS(=O)(=O)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cn2)cc(C(F)(F)F)c1 CHEMBL3932302 IC50 6.6 nM
Cc1c(OCC(O)CN2CCC(O)CC2)cn2ncnc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)c12 CHEMBL4277848 IC50 6.6 nM
O=C(Cc1ccncc1)N1CCc2nc(-c3cc4ccccc4[nH]c3=O)[nH]c2C1 CHEMBL2016925 IC50 6.7 nM
Cc1nc(N(C)c2ccc3c(c2)CCO3)c2cc(C)oc2n1 CHEMBL3403513 IC50 6.7 nM
N#Cc1ccc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2F)cc1Cl CHEMBL3910713 IC50 6.7 nM
COCCOc1cc2ncnc(NC3=CC(=O)C(OCc4cccc(F)c4)=C(Cl)C3=O)c2cc1OC CHEMBL3706823 IC50 6.8 nM
CC(=O)Nc1cccc(C(=O)c2ccc3c(/C=C/c4ccccc4)n[nH]c3c2)c1 CHEMBL3983004 Ki 6.8 nM
Cc1cc(Oc2cc(NC(=O)C3CC3)ncn2)ccc1NC(=O)Nc1ccc(Cl)c(OC(F)(F)F)c1 CHEMBL3895044 IC50 6.8 nM
CC1CN(c2cc(NC(=O)Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)c(F)c3)cc(C(F)(F)F)c2)CCO1 CHEMBL3949794 IC50 6.8 nM
CC(C)Nc1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(C(F)(F)F)c1 CHEMBL3920464 IC50 6.8 nM
Cc1cccc(C)c1NC(=O)c1ccc(NC(=O)Cn2c(=O)c3nncn3c3ccccc32)cc1 CHEMBL4860596 IC50 6.8 nM
Cc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1NC(=O)Nc1ccc(F)c(C(F)(F)F)c1 CHEMBL3894696 IC50 6.9 nM
c1ccc(-c2cnc(Nc3ccccn3)s2)cc1 CHEMBL98538 IC50 7.0 nM
COCCN(C)CCOc1ccc2[nH]c(-c3cc4ccccc4nc3O)cc2c1 CHEMBL118569 IC50 7.0 nM
COc1cc2c(Nc3cc(O)c(C)cc3F)ncnc2cc1OCC1CCN(C)CC1 CHEMBL1202473 IC50 7.0 nM
COCCOc1cc2ncnc(Nc3ccc(Cl)cc3F)c2cc1OC CHEMBL286160 IC50 7.0 nM
CN1CCN(CCCn2ccc(-c3cnc4c(-c5ccsc5)cnn4c3)cc2=O)CC1 CHEMBL118400 IC50 7.0 nM
Cc1ccc(Nc2ncnn3cc(NC(=O)OCCCn4nccn4)c(C(C)C)c23)cc1O CHEMBL178174 IC50 7.0 nM
O=C(Nc1ccc(-c2cccc3c2CNC3=O)cc1)Nc1cccc(C(F)(F)F)c1 CHEMBL410711 IC50 7.0 nM
COc1cc(OC)cc(-c2cc3cnc(NCCCCCN4CCOCC4)cc3nc2NC(=O)NC(C)(C)C)c1 CHEMBL191070 IC50 7.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2C)cc1-c1ccc2nc(NCCCN3CCOCC3)ncc2c1 CHEMBL214530 IC50 7.0 nM
CCCn1c2ccc(NC(=O)N(C)c3ccccc3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL219293 IC50 7.0 nM
CC(C)Cn1c2ccc(NC(=O)c3cccs3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL426703 IC50 7.0 nM
CS(=O)(=O)C1CCN(Cc2ccnc(Nc3ncc(C#N)s3)c2)CC1 CHEMBL224842 IC50 7.0 nM
CN(C)CCc1ccc(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)cc1 CHEMBL234452 IC50 7.0 nM
CN1CCN(CCc2ccc(Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)cc2)CC1 CHEMBL233224 IC50 7.0 nM
CCNC(=O)Nc1ccc(CNc2ncsc2C(=O)Nc2ccc3c(c2)OC(F)(F)O3)cn1 CHEMBL247798 IC50 7.0 nM
COc1cc(Nc2ncnc(-n3c(Nc4ccccc4)nc4ccccc43)n2)cc(OC)c1OC CHEMBL271131 IC50 7.0 nM
CNc1cc(Oc2ccc3c(C(=O)Nc4ccc(Cl)cc4)cccc3c2)ccn1 CHEMBL272827 IC50 7.0 nM
CC(C)Cn1c2ccc(C(=O)c3sccc3Cl)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL269924 IC50 7.0 nM
CCn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)N5CCN(c6ccc(F)cc6)C5=O)cc4F)c3s2)c1 CHEMBL464211 IC50 7.0 nM
O=C1Nc2cc([N+](=O)[O-])ccc2/C1=C(/Nc1ccc(CN2CCCCC2)cc1)c1ccccc1 CHEMBL501751 IC50 7.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cnc4c(-c5cccnc5)cnn4c3N)cc2)c1 CHEMBL453578 IC50 7.0 nM
CCn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)CC(=O)Nc5ccccc5O)cc4F)c3s2)c1 CHEMBL584701 IC50 7.0 nM
COc1ccc(C(F)(F)F)cc1NC(=O)Nc1cccc(-c2cn3ccnc3c(NCc3ccncc3)n2)c1 CHEMBL1079846 IC50 7.0 nM
Cn1ncc2c1CCc1c-2c2c(c3c4cc(C5CCCCO5)ccc4n(CCO)c13)CNC2=O CHEMBL1085296 IC50 7.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN(C)C)cnc(N)c34)cc2)c1 CHEMBL1979883 IC50 7.0 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(Cl)c5)cc4)csc23)cn1 CHEMBL2023228 IC50 7.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cnn(Cc4ccccc4)c3)ncc2Cl)[C@H]2C=C[C@@H]1C2 CHEMBL2071217 IC50 7.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2cccc(F)c2)c2ncc[nH]2)C(=O)N3)CC1 CHEMBL2086759 IC50 7.0 nM
Cc1cc(-c2cc(NC(=O)c3ccc(CN4CCN(C)CC4)cc3)[nH]n2)ccc1NC(=O)Nc1cc(C(C)(C)C)on1 CHEMBL2386796 IC50 7.0 nM
CC(=O)Nc1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCN(C(=O)N1CCOCC1)C3)C(=O)N2 CHEMBL2403374 IC50 7.0 nM
Nc1nccc2occ(-c3ccc4c(C(=O)Nc5ccccc5)cccc4c3)c12 CHEMBL3288524 IC50 7.0 nM
CCNC(=O)c1cccc2cc(-c3cccc4[nH]nc(N)c34)ccc12 CHEMBL3288522 IC50 7.0 nM
CCc1cc(NC(=O)Nc2ccc(-c3cnc(Nc4cc(N5CCC(N)C5)nc(C)n4)s3)cc2)no1 CHEMBL3593291 IC50 7.0 nM
Cc1ccc(NC(=O)Nc2ccc(-c3nsc(NC(=O)NCCCO)c3C(N)=O)cc2)cc1 CHEMBL3696084 IC50 7.0 nM
CN1CCN(c2ccc(Nc3ncc4nc(Nc5ccccc5)n(C5CCCC5)c4n3)cc2)CC1 CHEMBL2178352 IC50 7.0 nM
CC(=O)N1CCc2c(ncnc2Oc2ccc3c(ccn3C(=O)Nc3cccc(C(F)(F)F)c3)c2)C1 CHEMBL3746052 IC50 7.0 nM
Cc1cccc(NC(=O)c2cccc(N3CCc4c(cnc5ccccc45)C3)c2)c1 CHEMBL3895520 IC50 7.0 nM
CC(C)c1cccc(NC(=O)c2cccc(N3CCc4c(cnc5ccccc45)C3)c2)c1 CHEMBL3984316 IC50 7.0 nM
CC(C)c1cccc(NC(=O)c2cccc(N3CCc4c(cnc5cc(CO)c(CO)cc45)C3)c2)c1 CHEMBL3899614 IC50 7.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(C(=O)NCCCN5CCOCC5)sc34)cc2F)c1 CHEMBL3918251 IC50 7.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(C(=O)NCCCN5CCOC(CO)C5)sc34)cc2)c1 CHEMBL3904954 IC50 7.0 nM
CCOC(=O)N1CCN(CCNC(=O)c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)ccc5F)c(F)c4)c3s2)CC1 CHEMBL3890520 IC50 7.0 nM
CCOC(=O)CN1CCN(C(=O)c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)ccc5F)c(F)c4)c3s2)CC1 CHEMBL3965868 IC50 7.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(C(=O)NCCCN5CCCC(CO)C5)sc34)cc2F)c1 CHEMBL3967877 IC50 7.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(C(=O)NCCCN5CCC(O)CC5)sc34)cc2F)c1 CHEMBL3910242 IC50 7.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(C(=O)NCCCN)sc34)cc2F)c1 CHEMBL3898150 IC50 7.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(C(=O)N[C@@H](CCC(=O)OC(C)(C)C)C(=O)O)sc34)cc2F)c1 CHEMBL3966382 IC50 7.0 nM
CCN(CC)C(=O)c1cc2nccc(Oc3cccc(C(=O)Nc4cc(C)ccc4F)c3)c2s1 CHEMBL3920518 IC50 7.0 nM
Cc1ccc(Oc2cc(NC(=O)C3CC3)ncn2)cc1NC(=O)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL3976169 IC50 7.0 nM
Cc1cc(NC(=O)Nc2ccc(F)c(C(F)(F)F)c2)ccc1Oc1cc(NC(=O)C2CC2)ncn1 CHEMBL3906608 IC50 7.0 nM
NC(=O)c1c(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)[nH]c2ccccc12 CHEMBL3913556 IC50 7.0 nM
CCc1cccc(NC(=O)Nc2ccc(-c3[nH]c4ccccc4c3C(N)=O)cc2)c1 CHEMBL3975267 IC50 7.0 nM
NC(=O)CCn1cc(-c2ccc3ncnc(Nc4cc(O)c(F)cc4F)c3c2)nn1 CHEMBL5418423 IC50 7.0 nM
COc1cc(-c2cc(NC(=O)Nc3ccc(OCCN4CCCCC4)cc3)cc(OC)c2OC)ccc1/C(C)=N/O CHEMBL3220320 IC50 7.01 nM
C=CC(=O)Nc1cccc(-c2ccc(NC(=O)Nc3ccc(C)c(Cl)c3)cc2)n1 CHEMBL4160813 IC50 7.05 nM
Nc1n[nH]c2ccnc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)c12 CHEMBL404571 IC50 7.1 nM
O=C(Nc1ccc(N2CCn3ccc4ncnc2c43)cc1)Nc1cccc(C(F)(F)F)c1 CHEMBL1254096 IC50 7.1 nM
O=C(Nc1cccc(Oc2ccc3nccn3n2)c1)c1cccc(C(F)(F)F)c1 CHEMBL2206666 IC50 7.1 nM
Cn1cc(C(=O)Nc2ccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)cc2)c(=O)n1-c1ccccc1 CHEMBL3093587 IC50 7.1 nM
Nc1nccc2scc(-c3ccc4c(C(=O)Nc5ccccc5)cccc4c3)c12 CHEMBL3288525 IC50 7.1 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1)Nc1cc(F)cc(C(F)(F)F)c1 CHEMBL3964861 IC50 7.1 nM
N#Cc1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)cc(C(F)(F)F)c1 CHEMBL3951823 IC50 7.1 nM
CC(F)(F)c1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)c1 CHEMBL3893548 IC50 7.1 nM
Cc1cc2c(F)c(Oc3cc(Nc4ccc(CS(C)(=O)=O)cc4)ncn3)ccc2[nH]1 CHEMBL5187154 IC50 7.1 nM
N#Cc1ccc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc1C(F)(F)F CHEMBL3940692 IC50 7.18 nM
CCNC(=O)c1cccc2cc(Oc3ccnc(Nc4cccc(CS(C)(=O)=O)c4)n3)ccc12 CHEMBL3742328 IC50 7.2 nM
Cc1c(OCC(O)CO)cn2ncnc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)c12 CHEMBL4292983 IC50 7.2 nM
COCCOc1cc2ncnc(NC3=CC(=O)C(N4CC(C)OC4=O)=CC3=O)c2cc1OC CHEMBL3706839 IC50 7.3 nM
Nc1n[nH]c2cccc(-c3ccc4c(C(=O)Nc5cccc(C(F)(F)F)c5)cccc4c3)c12 CHEMBL3288507 IC50 7.3 nM
CCN=C(S)NNc1nncc2ccccc12 CHEMBL1380839 IC50 7.3 nM
CN(C)C1CCN(c2cc(NC(=O)Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)c(F)c3)cc(C(F)(F)F)c2)C1 CHEMBL3986639 IC50 7.3 nM
CC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3cc(NC(=O)C4CC4)ncn3)cc2F)ccc1Cl CHEMBL3977258 IC50 7.3 nM
CC(C)(C#N)c1cccc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)sc4c3CO)c2)c1 CHEMBL3125881 IC50 7.4 nM
Cc1cc(NC(=O)Nc2ccc(F)c(C(C)(F)F)c2)ccc1Oc1cc(NC(=O)C2CC2)ncn1 CHEMBL3940325 IC50 7.4 nM
CN(c1ccc(NC(=O)Nc2cccc(C(F)(F)F)c2)c(F)c1)c1cc(NC(=O)C2CC2)ncn1 CHEMBL3934657 IC50 7.4 nM
Nc1n[nH]c2cc(-c3cnn(CC(=O)Nc4cccc(C(F)(F)F)c4)c3)ccc12 CHEMBL4861302 IC50 7.4 nM
N#CCc1nnc(NC(=O)c2ccco2)s1 CHEMBL5434432 IC50 7.4 nM
C[C@@H](Oc1ccc2[nH]nc(-c3nc4cc(N5CCN(C)CC5)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3827178 IC50 7.5 nM
NC(=S)NNc1nncc2ccccc12 CHEMBL3977192 IC50 7.5 nM
O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cn1 CHEMBL3984709 IC50 7.5 nM
COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(F)ccc4F)cc3)cc2[nH]1 CHEMBL243909 IC50 7.6 nM
CN(c1ccc2cn(C)nc2c1)c1ccnc(Nc2cccc(S(N)(=O)=O)c2)n1 CHEMBL478402 IC50 7.6 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4ccccc4)ccc32)c(C)c1C(=O)O CHEMBL1173107 IC50 7.6 nM
Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cnn(C(C)(C)C)c4)c(Cl)c3)c21 CHEMBL1254356 IC50 7.6 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc4c(C(=O)NC5CCC5)cccc4c3)n2)c1 CHEMBL3741625 IC50 7.6 nM
CS(=O)(=O)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)cc(C(F)(F)F)c1 CHEMBL3928460 IC50 7.6 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1)Nc1cc(Cl)ccc1F CHEMBL3935930 IC50 7.6 nM
N#C/C(=C\c1cccs1)c1nnc(NC(=O)c2ccco2)s1 CHEMBL5434411 IC50 7.6 nM
Fc1ccccc1-c1cn(Cc2ccc(-c3cncnc3)cc2)nn1 CHEMBL4459732 IC50 7.63 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=S)Nc4ccc(Cl)c(Cl)c4)cc3)c12 CHEMBL4175943 IC50 7.66 nM
O=C1Nc2ccccc2/C1=C/c1c[nH]nc1-c1ccccc1[N+](=O)[O-] CHEMBL2347053 IC50 7.7 nM
CN(C)c1ccc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)nn1 CHEMBL3690475 IC50 7.79 nM
CC(Oc1ccc2[nH]nc(-c3nc4cc(C5CCN(C)CC5)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3827268 IC50 7.8 nM
O=S(=O)(Nc1ccccn1)c1ccc(Nc2nncc3ccccc23)cc1 CHEMBL3978686 IC50 7.8 nM
CC(F)(F)c1cc(F)cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2F)c1 CHEMBL3984219 IC50 7.8 nM
CN1CCC(c2cc(NC(=O)Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cn3)cc(C(F)(F)F)c2)CC1 CHEMBL3986769 IC50 7.8 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1)Nc1cccc(OC(F)(F)F)c1 CHEMBL3977612 IC50 7.8 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1)Nc1ccc(C(F)(F)F)cc1Cl CHEMBL3924816 IC50 7.8 nM
O=C(Nc1cccc(C(F)(F)F)c1)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1F CHEMBL3972921 IC50 7.8 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(C(=O)Nc5ccc(Cl)cc5Cl)CC4)cc3)c12 CHEMBL4072514 IC50 7.8 nM
CCc1ccc(N(C)c2ncnc3occ(C)c23)cc1 CHEMBL4242522 IC50 7.8 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4nnc(CCN5CCCCC5)s4)ccn23)c1 CHEMBL3690387 IC50 7.85 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4nc5c(s4)CNCC5)ccn23)c1 CHEMBL3690416 IC50 7.85 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4ccc(Cl)cc4)ccc32)c(C)c1C(=O)O CHEMBL1172421 IC50 7.9 nM
CO/N=C/c1c(N)ncnc1Oc1ccc(NC(=O)Nc2ccccc2C)c(Cl)c1 CHEMBL1681948 IC50 7.9 nM
Cc1cc(NC(=O)Nc2cc(C(C)(F)F)ccc2F)ccc1Oc1cc(NC(=O)C2CC2)ncn1 CHEMBL3914631 IC50 7.9 nM
CCN1CCc2c(ncnc2Oc2ccc3c(ccn3C(=O)Nc3cc(C4CC4)on3)c2)C1 CHEMBL4077291 IC50 7.9 nM
Nc1cc(Oc2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)ncn1 CHEMBL4849349 IC50 7.9 nM
COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C(F)(F)F)on4)c3)c2cc1OC CHEMBL2029988 Kd 7.9 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=S)Nc4cc(OC(F)(F)F)ccc4Br)cc3)c12 CHEMBL4168788 IC50 7.94 nM
COc1cc2nccc(Nc3ccc4c(C(=O)Nc5ccc(Cl)cc5)cccc4c3)c2cc1OC CHEMBL270277 pIC50 7.943 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#Cc5cccnc5)cnc(N)c34)cc2)c1 CHEMBL1971947 pKi 7.943 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3c(F)ccc4[nH]nc(N)c34)cc2)c1 CHEMBL1996255 pKi 7.943 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(C)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1984162 pKi 7.943 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 7.943 nM
Nc1n[nH]c2cc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)ccc12 CHEMBL1997623 pKi 7.943 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN)cnc(N)c34)cc2)c1 CHEMBL1965988 pKi 7.943 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 CHEMBL49120 pKi 7.943 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cc(CO)ccc4F)cc3)c12 CHEMBL1985311 pKi 7.943 nM
CCN1CCN(c2ccc(Nc3ncc(C#N)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1973516 pKi 7.943 nM
Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12 CHEMBL394790 pKi 7.943 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)c(F)c2)c1 CHEMBL1994638 pKi 7.943 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCNS(C)(=O)=O)cnc(N)c34)cc2)c1 CHEMBL1994321 pKi 7.943 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(OC(F)F)cc5)cc4)csc23)cn1 CHEMBL1988387 pKi 7.943 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)O)c5)cnc(N)c34)cc2)c1 CHEMBL1989708 pKi 7.943 nM
C=CC(=O)Nc1ccc(-c2ccc(NC(=O)Nc3ccc(F)cc3)cc2)cn1 CHEMBL4171943 IC50 7.97 nM
O=c1[nH]c2ccccc2cc1-c1cc2ccccc2[nH]1 CHEMBL221736 IC50 8.0 nM
O=C(O)C1CCN(CCCOc2ccc3[nH]c(-c4cc5ccccc5nc4O)cc3c2)CC1 CHEMBL118748 IC50 8.0 nM
COc1cc2c(Nc3cc(O)c(Cl)cc3F)ncnc2cc1OCC1CCN(C)CC1 CHEMBL2448066 IC50 8.0 nM
COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OC/C=C/CN1CCCC1 CHEMBL1202478 IC50 8.0 nM
CC(C)OCc1ccc2c(c1)c1c3c(c4c(c1n2CCCO)Cc1ccccc1-4)C(=O)NC3 CHEMBL150894 IC50 8.0 nM
COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCc1ccsc1 CHEMBL151067 IC50 8.0 nM
Cc1cccc(Nc2nnc(Cc3ccncc3)c3ccccc23)c1 CHEMBL78303 ED50 8.0 nM
COc1cc(OC)cc(-c2cc3cnc(NCCCCO)cc3nc2NC(=O)NC(C)(C)C)c1 CHEMBL425363 IC50 8.0 nM
COc1cc(OC)cc(-c2cc3cnc(NCCCCCN4CCN(C)CC4)cc3nc2NC(=O)NC(C)(C)C)c1 CHEMBL189691 IC50 8.0 nM
CONC(=O)c1cc(Nc2ncnn3cc(-c4ncc(C)o4)c(C(C)C)c23)c(F)cc1F CHEMBL193306 IC50 8.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3nsc4ncnc(N)c34)cc2)c1 CHEMBL262433 IC50 8.0 nM
CNc1ncc2cc(-c3cc(C(=O)Nc4ccc(OC5CCN(C)CC5)cc4)ccc3C)ccc2n1 CHEMBL427226 IC50 8.0 nM
CNc1ncc2cc(-c3cc(C(=O)Nc4cccc(C(F)(F)F)c4C)ccc3C)ccc2n1 CHEMBL215969 IC50 8.0 nM
CCCn1c2ccc(NC(=O)Nc3ccc(C)cc3)cc2c2c3c(c4c(c21)CC(C=N)=CC4)C(=O)NC3 CHEMBL387174 IC50 8.0 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12 CHEMBL375670 IC50 8.0 nM
N#Cc1cnc(Nc2cc(CN3CCN(C(N)=O)CC3)ccn2)s1 CHEMBL375306 IC50 8.0 nM
N#Cc1cnc(Nc2cc(CN3CCOCC3)ccn2)s1 CHEMBL373693 IC50 8.0 nM
CC(=O)N1CCN(Cc2ccnc(Nc3ncc(-c4ccccc4)s3)c2)CC1 CHEMBL221926 IC50 8.0 nM
CN1CCN(Cc2ccc3c(c2)Cc2c(-c4csc(C#CCCO)c4)n[nH]c2-3)CC1 CHEMBL225639 IC50 8.0 nM
COCC#Cc1cc(-c2n[nH]c3c2Cc2cc(CN4CCN(C)CC4)ccc2-3)cs1 CHEMBL225036 IC50 8.0 nM
COc1cc2ncnc(Oc3ccc4[nH]c(Nc5ccc(Cl)cc5)nc4c3)c2cc1OC CHEMBL396265 Ki 8.0 nM
Cn1cc(/C=C2\C(=O)NN=C2c2cnns2)c2c(Br)cccc21 CHEMBL250197 IC50 8.0 nM
O=C(Nc1ccc(Cl)cc1)c1cccnc1NCc1ccncc1 CHEMBL250228 Ki 8.0 nM
O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cccnc1NCc1ccncc1 CHEMBL400512 Ki 8.0 nM
Cc1ccc(NC(=O)Nc2ccc(-c3cccc4onc(N)c34)cc2)cc1Cl CHEMBL270506 IC50 8.0 nM
COc1ccc(NC(=O)Nc2ccc(-c3cccc4onc(N)c34)cc2)cc1Cl CHEMBL272453 IC50 8.0 nM
Nc1noc2cccc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12 CHEMBL271600 IC50 8.0 nM
COc1ccc(-c2ccc(NC(=O)Nc3cccc(Br)c3)cc2)c2c(N)noc12 CHEMBL271381 IC50 8.0 nM
CC(C)Cn1c2ccc(C(=O)c3ccoc3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL411520 IC50 8.0 nM
COc1cc2nccc(Oc3ccc4c(NC(=O)Nc5ccc(C(F)(F)F)cc5Cl)nn(C)c4c3)c2cc1OC CHEMBL452088 IC50 8.0 nM
COc1cc2nccc(Oc3ccc4c(NC(=O)c5ccccc5Cl)nn(C)c4c3)c2cc1OC CHEMBL462562 IC50 8.0 nM
Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)N5CCN(c6ccccc6)C5=O)cc4F)c3s2)c1 CHEMBL462232 IC50 8.0 nM
O=C(Nc1ccc(Oc2ccnc3cc(-c4cn(CCCN5CCCC5)cn4)sc23)c(F)c1)N1CCN(c2ccccc2)C1=O CHEMBL449757 IC50 8.0 nM
CNC(=O)N1CCN(Cc2ccc(-c3cc4nccc(Oc5ccc(NC(=O)N6CCN(c7ccccc7)C6=O)cc5F)c4s3)cc2)CC1 CHEMBL503016 IC50 8.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(CC(=O)N(C)C)C(C)=O)cc1)c1ccccc1 CHEMBL498088 IC50 8.0 nM
COc1cc2nccc(CN3CCc4c(C(=O)Nc5ccc(C(C)(C)C)cc5)cccc4C3=O)c2cc1OC CHEMBL494873 IC50 8.0 nM
CC(C)(C)c1ccc(NC(=O)c2cccc3c2CCN(Cc2ccnc4ccccc24)C3)cc1 CHEMBL494267 IC50 8.0 nM
CCCn1c2ccc(C3CCCCO3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL1084061 IC50 8.0 nM
Cn1ncc2c1CCc1c-2c2c(c3c1[nH]c1ccc(C4CCCCO4)cc13)CNC2=O CHEMBL1083071 IC50 8.0 nM
Cc1c(/C=C2\C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)N(CCN1CCCC1)CC2 CHEMBL1276890 IC50 8.0 nM
CC1=CC[C@@H]2[C@@H](C1)c1c(O)cc(CCCCCBr)cc1OC2(C)C CHEMBL1683647 Ki 8.0 nM
CCCCCCCCCn1cc2c(N)ncnc2n1 CHEMBL189168 Ki 8.0 nM
O=C(CN1CCCCC1)N1CCc2nc(-c3cc4cc(F)ccc4[nH]c3=O)[nH]c2C1 CHEMBL2016919 IC50 8.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5ccoc5)cnc(N)c34)cc2)c1 CHEMBL2023222 IC50 8.0 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(Cl)cc5)cc4)csc23)cn1 CHEMBL2023229 IC50 8.0 nM
COc1cc2ncnc(Oc3ccc(CC(=O)Nc4cnn(C(C)C)c4)cc3)c2cc1OC CHEMBL1940274 IC50 8.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2ccc(C)cc2)c2nc4ccccc4[nH]2)C(=O)N3)CC1 CHEMBL2086754 IC50 8.0 nM
COc1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCN(C(=O)CCN)C3)C(=O)N2 CHEMBL2403366 IC50 8.0 nM
Cc1[nH]c2c(c1C(=O)N1CCC(N3CCCCC3)CC1)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430252 IC50 8.0 nM
O=C(Nc1ccc(Oc2ncnc3ccccc23)cc1)Nc1cccc(Br)c1 CHEMBL3628807 IC50 8.0 nM
COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)c(Cl)c3)c2cc1OC CHEMBL3628806 IC50 8.0 nM
CCn1cc(CN(Cc2ccc(-c3cc4nccc(Oc5ccc6oc(Nc7ccc(Cl)cc7)nc6c5)c4s3)nc2)C(C)C)nn1 CHEMBL3633687 IC50 8.0 nM
Cc1ccc(NC(=O)Nc2ccc(-c3nsc(NC(=O)NCCCN4CCOCC4)c3C(N)=O)cc2)cc1 CHEMBL3696076 IC50 8.0 nM
NC(=O)c1c(-c2ccc(NC(=O)Nc3ccccc3)cc2)nsc1NC(=O)NCCCN1CCOCC1 CHEMBL3696072 IC50 8.0 nM
C=S(C)(=O)NC(=O)c1c[nH]c(-c2cc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)ccn2)c1 CHEMBL3656122 IC50 8.0 nM
CNCc1cc(Oc2ccc3c(ccn3C(=O)Nc3cccc(C(F)(F)F)c3)c2)ncn1 CHEMBL3747063 IC50 8.0 nM
C[C@@H]1NCc2ncnc(Oc3ccc4c(ccn4C(=O)Nc4cc(C(C)(C)C)on4)c3)c21 CHEMBL3746141 IC50 8.0 nM
CC(Oc1ccc2[nH]nc(-c3nc4cc(N5CCN(C)CC5)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3828740 IC50 8.0 nM
O=C(NCC(F)(F)F)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL3972427 Ki 8.0 nM
CC(=O)N1CCC(n2cc(-c3ccn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)cn2)CC1 CHEMBL3690426 IC50 8.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1N1CCc2nc(N)ncc2C1 CHEMBL3702661 IC50 8.0 nM
COC(=O)c1cncc2c1CCN(c1cccc(C(=O)Nc3cccc(C(F)(F)F)c3)c1)C2 CHEMBL3644555 IC50 8.0 nM
CC(C)c1ccc(NC(=O)c2cccc(N3CCc4c(cnc5ccccc45)C3)c2)cc1 CHEMBL3950471 IC50 8.0 nM
CS(C)(=O)=NC(=O)c1cncc(C#Cc2cccc(NC(=O)Nc3ccccc3F)c2)c1 CHEMBL3919069 IC50 8.0 nM
Cc1cccc(NC(=O)Nc2cccc(C#Cc3cncc(C(=O)N=S(C)(C)=O)c3)c2)c1 CHEMBL3980266 IC50 8.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3cc(C)ccc3F)c2)c1 CHEMBL3960598 IC50 8.0 nM
COc1cc(Nc2ncc3c(n2)CCN(C(=O)c2cccs2)C3)cc(OC)c1OC CHEMBL3919045 IC50 8.0 nM
NC(=O)n1c(-c2ccc(NC(=O)Nc3ccc(F)c(Cl)c3)cc2)cc2ccccc21 CHEMBL3938792 IC50 8.0 nM
CN1C(=O)C2(CC2)c2cc(NC(=O)Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3)ccc21 CHEMBL3926270 IC50 8.0 nM
O=C(Nc1cc(-c2ccncc2)cc(C(F)(F)F)c1)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1 CHEMBL3959327 IC50 8.0 nM
CSc1ncc2c(n1)CCN(c1cc(C(=O)Nc3cccc(C(F)(F)F)c3)ccc1C)C2 CHEMBL3920210 IC50 8.0 nM
CC(C)c1cccc(NC(=O)c2cccc(N3CCc4c(cnc5ccnn45)C3)c2)c1 CHEMBL3978214 IC50 8.0 nM
CN1CCN(CC(=O)N(C)c2ccc(N/C(=C3\C(=O)Nc4cc(-c5cnco5)ccc43)c3ccccc3)cc2)CC1 CHEMBL4161897 IC50 8.0 nM
Nc1nc(Nc2ccc3c(c2)CC[C@@H](N2CCCC2)CC3)nn1-c1cc2c(nn1)-c1ccccc1CCC2 CHEMBL3809489 IC50 8.0 nM
CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(CC(C)(C)N)c(C(F)(F)F)c2)c(F)c1 CHEMBL4218563 IC50 8.0 nM
Cn1cc(-c2[nH]c3cc(NC(=O)[C@H](N)C4CCCCC4)cc4c3c2C=NNC4=O)cn1 CHEMBL3990456 IC50 8.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 IC50 8.0 nM
Cc1cc(Oc2cc(NC(=O)C3CC3)ncn2)ccc1NC(=O)Nc1cc(OC(F)(F)F)ccc1F CHEMBL3889544 IC50 8.1 nM
Cc1cc(NC(=O)Nc2cccc(OC(F)(F)F)c2)ccc1Oc1cc(NC(=O)C2CC2)ncn1 CHEMBL3976140 IC50 8.1 nM
Cc1cc(NC(=O)Nc2cc(F)cc(C(C)(F)F)c2)ccc1Oc1ccnc(NC(=O)C2CC2)c1 CHEMBL3945523 IC50 8.1 nM
COc1cc2c(Oc3ccc(NC(=O)NC4CCCC4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 CHEMBL5438648 IC50 8.19 nM
CN1CCC(Oc2cc(NC(=O)Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)c(F)c3)cc(C(F)(F)F)c2)C1 CHEMBL3986500 IC50 8.2 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1)Nc1ccc2[nH]cc(F)c2c1 CHEMBL3909258 IC50 8.2 nM
Cc1cc(Oc2cc(NC(=O)C3CC3)ncn2)ccc1NC(=O)Nc1ccc(C#N)c(Cl)c1 CHEMBL3916488 IC50 8.3 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1)Nc1cc(C(F)(F)F)ccc1F CHEMBL3930655 IC50 8.3 nM
O=C(Nc1ccnc(C(F)(F)F)c1)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1 CHEMBL3931839 IC50 8.3 nM
Cc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1cc(C(C)(F)F)ccc1F CHEMBL3979083 IC50 8.3 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N2C(=O)CC[C@@H]2CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL4170680 IC50 8.3 nM
CCN(CC)c1ncc2c(n1)Nc1n[nH]c(C)c1N=C2c1ccc(C)cc1 CHEMBL4278759 IC50 8.3 nM
COc1cc(OC)cc(N(CCCN2CC(O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3907314 pIC50 8.318 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1F)Nc1cc(C(F)(F)F)ccc1F CHEMBL3908336 IC50 8.4 nM
COc1ccc(N(C)c2nc(C)nc3ccccc23)cc1 CHEMBL492399 IC50 8.4 nM
CCCN(c1ccc(OC)cc1)c1nc(C)nc2oc(C)cc12 CHEMBL3297900 IC50 8.5 nM
O=S(=O)(Nc1ncccn1)c1ccc(Nc2nncc3ccccc23)cc1 CHEMBL3908272 IC50 8.5 nM
CCNc1nnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)s1 CHEMBL3694678 IC50 8.5 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1200485 IC50 8.5 nM
O=C(Cc1ccncc1)N1CCc2nc(-c3cc4cc(F)ccc4[nH]c3=O)[nH]c2C1 CHEMBL2016926 IC50 8.6 nM
O=S(=O)(Nc1nccs1)c1ccc(Nc2nncc3ccccc23)cc1 CHEMBL3970399 IC50 8.6 nM
O=C(Nc1cccc(C(F)(F)F)c1)Nc1ccc(Oc2cc(NC(=O)C3CC3)ncn2)cc1F CHEMBL3975481 IC50 8.6 nM
CC(F)(F)c1cc(NC(=O)Nc2cccc(Oc3cc(NC(=O)C4CC4)ncn3)c2)ccc1Cl CHEMBL3962147 IC50 8.7 nM
COc1ccc(NC(=O)Nc2cnc(Oc3ccnc(NC(=O)C4CC4)c3)c(C)c2)cc1C(F)(F)F CHEMBL3964796 IC50 8.7 nM
O=C(Nc1ccc(F)c(C2CC2)c1)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1F CHEMBL3969348 IC50 8.7 nM
COc1cc2ncnc(Oc3ccc(NC(=O)NC4(C#N)CCCC4)c4ccccc34)c2cc1OC CHEMBL4092026 IC50 8.7 nM
O=C(Cn1c(=O)c2nncn2c2ccccc21)Nc1ccc(C(=O)NNC(=O)c2ccccc2)cc1 CHEMBL4864736 IC50 8.7 nM
CCN(CC)CCOc1ccc(NC(=O)c2cccc(-c3cccc(O)c3)c2)cc1F CHEMBL3397934 IC50 8.74 nM
Cc1cccc(NC(=O)c2cccc3cc(Oc4ccnc(Nc5cccc(CS(C)(=O)=O)c5)n4)ccc23)c1 CHEMBL3739572 IC50 8.8 nM
O=C(Nc1cc(C2CC2)on1)n1ccc2cc(Oc3cc(CO)ncn3)ccc21 CHEMBL4074672 IC50 8.8 nM
O=C(Nc1cc(Oc2ccc(Nc3nccc4[nH]cc(-c5ccc(F)cc5)c(=O)c34)cc2F)ccn1)C1CC1 CHEMBL4434974 IC50 8.8 nM
COC(C)Oc1cc2ncnc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2c2c1OCCO2 CHEMBL5426655 IC50 8.8 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(Cl)cc(Cl)c4)cc3)c2cc1OC CHEMBL440202 IC50 8.9 nM
Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)c(Cl)c3)c21 CHEMBL1253194 IC50 8.9 nM
COc1cc(-c2cc(NC(=O)Nc3cc(OCCN4CCCC4)ccc3C)cc(OC)c2OC)ccc1/C(C)=N/O CHEMBL3220328 IC50 8.9 nM
NC1CCN(c2ccc(-c3ccn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)nn2)CC1 CHEMBL3690438 IC50 8.9 nM
O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)Nc1ccc(Oc2cc(NC(=O)C3CC3)ncn2)cc1F CHEMBL3924928 IC50 8.9 nM
Cc1cc(Oc2cc(NC(=O)C3CC3)ncn2)ccc1NC(=O)Nc1ccc(C)c(C(F)(F)F)c1 CHEMBL3904153 IC50 8.9 nM
COc1cc(OC)cc(N(CCCN2CCC(O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3962736 pIC50 8.913 nM
COc1cc(OC)cc(N(CCCN2CCC(O)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 CHEMBL3984039 pIC50 8.913 nM
COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCCCN1CCOCC1 CHEMBL24137 IC50 9.0 nM
COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCCN1CCN(C)CC1 CHEMBL1202477 IC50 9.0 nM
Cc1cc(CO)cc(Nc2nccc(-n3ccnc3-c3ccccc3)n2)c1 CHEMBL297769 IC50 9.0 nM
c1ccc(-c2cnn3cc(-c4ccc(OCCN5CCOCC5)cc4)cnc23)cc1 CHEMBL331465 IC50 9.0 nM
CC(C)(C)c1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1 CHEMBL431006 ED50 9.0 nM
COc1cc(OC)cc(-c2cc3cnc(NCCCN4CCOCC4)cc3nc2NC(=O)NC(C)(C)C)c1 CHEMBL339856 IC50 9.0 nM
COCCOc1cc2ncnc(NC3=CC(=O)C(Br)=CC3=O)c2cc1OC CHEMBL3706818 IC50 9.0 nM
N#Cc1cnc(Nc2cc(N3CCN(CCN4CCCC4)CC3)ncn2)s1 CHEMBL380735 IC50 9.0 nM
COCCN1CCN(c2cc(Nc3ncc(C#N)s3)ncn2)CC1 CHEMBL379896 IC50 9.0 nM
N#Cc1cnc(Nc2cc(N3CCCC(N)CC3)ncn2)s1 CHEMBL204163 IC50 9.0 nM
Cn1cc(/C=C2\C(=O)NN=C2c2cnccn2)c2c(Cl)cccc21 CHEMBL378403 IC50 9.0 nM
CCCn1c2ccc(N)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL373397 IC50 9.0 nM
CCCn1c2ccc(NC(=O)Nc3ccccc3Cl)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL219253 IC50 9.0 nM
CCCn1c2ccc(NC(=O)Nc3ccccc3F)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL424910 IC50 9.0 nM
N#Cc1cnc(Nc2cc(CN3CCN(C(=O)CO)CC3)ccn2)s1 CHEMBL222852 IC50 9.0 nM
NC(=O)N1CCN(Cc2ccc3c(c2)Cc2c(-c4csc(C#CCOc5ccccc5)c4)n[nH]c2-3)CC1 CHEMBL225261 IC50 9.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4ccnc(N)c34)cc2)c1 CHEMBL394619 IC50 9.0 nM
CNC(=O)c1cc(Oc2ccc3nc(Nc4ccc(Cl)c(C(F)(F)F)c4)[nH]c3c2)ccn1 CHEMBL394826 Ki 9.0 nM
CNC(=O)c1cc(Oc2ccc3[nH]c(Nc4ccc(C(F)(F)C(F)(F)F)c(OC[C@H]5CCCN5C)c4)nc3c2)ccn1 CHEMBL231067 Ki 9.0 nM
CNc1cc(-c2cccnc2Oc2ccc(Cl)c(NC(=O)c3cccc(C(C)C)c3)c2)ccn1 CHEMBL246151 IC50 9.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)c1cccnc1NCc1ccncc1 CHEMBL249179 Ki 9.0 nM
COc1cc2nccc(Oc3ccc4c(C(=O)NC5CCCC5)cccc4c3)c2cc1OC CHEMBL410903 IC50 9.0 nM
O=C(Cc1ccccc1)NC(=S)Nc1ccc(Oc2ccnc3cc(C(=O)N4CCCC4)sc23)c(F)c1 CHEMBL254964 IC50 9.0 nM
Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)C5(C(=O)Nc6ccccc6)CC5)cc4F)c3s2)c1 CHEMBL465131 IC50 9.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(CCCN(C)C)C(C)=O)cc1)c1ccccc1 CHEMBL525909 IC50 9.0 nM
Nc1c(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)cnc2ccnn12 CHEMBL510788 IC50 9.0 nM
CCn1c2ccc(C3CCCCO3)cc2c2c3c(c4c(c21)CCc1c-4cnn1C)C(=O)NC3 CHEMBL1082438 IC50 9.0 nM
Nc1ncnc2c1c(-c1ccc3[nH]ccc3c1)nn2C1CCCC1 CHEMBL1242295 IC50 9.0 nM
COCCn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)c(Cl)c3)c21 CHEMBL1253838 IC50 9.0 nM
CCCn1c2ccc(Nc3ncc(CC)cn3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL2010869 IC50 9.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5ccsc5)cnc(N)c34)cc2)c1 CHEMBL2023223 IC50 9.0 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)c12 CHEMBL424943 IC50 9.0 nM
NC(=O)[C@@H]1[C@H](Nc2nc(Nc3cnn(CCN4CCOCC4)c3)ncc2Cl)[C@H]2C=C[C@@H]1C2 CHEMBL2071274 IC50 9.0 nM
COCCN1CCC(Nc2ccc3c(c2)C(=C(c2ccccc2)c2nc4ccccc4[nH]2)C(=O)N3)CC1 CHEMBL2086752 IC50 9.0 nM
O=C(Nc1cccc(Br)c1)Nc1ccc(Oc2ncnc3sccc23)cc1Cl CHEMBL3628810 IC50 9.0 nM
Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(-c4cc(C(=O)NCC(O)CO)c[nH]4)c3)cc2)c1 CHEMBL3656113 IC50 9.0 nM
CC(C)n1c(Nc2ccc(C(F)(F)F)cc2)nc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc21 CHEMBL3678957 IC50 9.0 nM
CC(Oc1ccc2[nH]nc(-c3nc4cc(N5C[C@@H](C)N[C@@H](C)C5)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3828122 IC50 9.0 nM
C=C(c1ccccc1)c1ccc2c(/C=C/c3ccccc3)n[nH]c2c1 CHEMBL3901866 Ki 9.0 nM
CC(C)c1ccc(NC(=O)c2cccc(N3CCc4c(cnc5cc(CO)c(CO)cc45)C3)c2)cc1 CHEMBL3890120 IC50 9.0 nM
Cc1ccoc1C(=O)Nc1cccc(C#Cc2cncc(C(=O)N=S(C)(=O)CCCN3CCN(CCOCCO)CC3)c2)c1 CHEMBL3933421 IC50 9.0 nM
Cc1ccc(F)c(C(=O)Nc2cccc(C#Cc3cncc(C(=O)N=S(=O)(CCCO)CCCO)c3)c2)c1 CHEMBL3946490 IC50 9.0 nM
COC(=O)CNCCCNC(=O)c1cc2nccc(Oc3cccc(C(=O)Nc4cc(C)ccc4F)c3)c2s1 CHEMBL3944929 IC50 9.0 nM
COC(=O)CNCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1 CHEMBL3890891 IC50 9.0 nM
CCNC(=O)c1cc2nccc(Oc3cccc(NC(=O)c4occc4C)c3)c2s1 CHEMBL3977907 IC50 9.0 nM
Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc3cc(C(=O)OCCCO)sc23)c1 CHEMBL3943862 IC50 9.0 nM
NC(=O)n1c(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)cc2ccccc21 CHEMBL3920784 IC50 9.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cc4ccccc4n3C(N)=O)cc2)c1 CHEMBL3896265 IC50 9.0 nM
O=C(Nc1ccc(Oc2cc(NC(=O)C3CC3)ncn2)cc1)Nc1ccc(F)c(C(F)(F)F)c1 CHEMBL3912594 IC50 9.0 nM
Cc1n[nH]c2cc(SCCC(=O)Nc3ccc(CN4CCN(C)CC4)c(C(F)(F)F)c3)ccc12 CHEMBL4572281 GI50 9.0 nM
CN1CCN(Cc2ccc(NC(=O)CCSc3ccc4c(-c5cccnc5)n[nH]c4c3)cc2C(F)(F)F)CC1 CHEMBL4583593 GI50 9.0 nM
Cc1cc2c(F)c(Oc3ccnc(Nc4cccc(S(N)(=O)=O)c4)n3)ccc2[nH]1 CHEMBL5175208 IC50 9.0 nM
Cn1cc(-c2ccc3c(c2)ncn3-c2cc(NS(=O)(=O)C3CC3)cc(-c3ccc(F)cc3F)c2)cn1 CHEMBL3964954 IC50 9.0 nM
CN(C)C1CCN(c2ccc(-c3ccn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)nn2)CC1 CHEMBL3690400 IC50 9.06 nM
COCCOc1cc2ncnc(NC3=CC(=O)C(OC(CF)CF)=CC3=O)c2cc1OC CHEMBL2113175 IC50 9.1 nM
Cc1cccc(C(=O)Nc2cccc([C@H](C)Nc3cncc(Cl)n3)c2)c1 CHEMBL504075 Kd 9.1 nM
N#Cc1ccc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cn2)cc1C(F)(F)F CHEMBL3975944 IC50 9.1 nM
CC(F)(F)c1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2F)c1 CHEMBL3913137 IC50 9.1 nM
Cc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1NC(=O)Nc1cccc(C(F)(F)F)c1 CHEMBL3946208 IC50 9.1 nM
Nc1n[nH]c2cccc(-c3ccc4c(C(=O)Nc5ccc(F)cc5)cccc4c3)c12 CHEMBL3288513 IC50 9.2 nM
O=C(Nc1cc(Oc2cc(F)c(NC(=O)C3(C(=O)Nc4ccc(F)cc4)CC3)cc2F)ccn1)C1CC1 CHEMBL3545365 IC50 9.2 nM
CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ncnc5ccn(C)c45)cc3Cl)cc2C(F)(F)F)CC1 CHEMBL1254755 IC50 9.3 nM
COCCNc1nnc(-c2ccn3c(-c4cccc(NC(=O)NCC(F)(F)F)c4)cnc3c2)s1 CHEMBL3694680 IC50 9.3 nM
O=C(Nc1cccc(C(F)(F)F)c1)Nc1ccc(Nc2ccnc(NC(=O)C3CC3)c2)cc1F CHEMBL3910653 IC50 9.3 nM
CN1CCN(CC(=O)N(C)c2ccc(N/C(=C3\C(=O)Nc4cc(-c5ccco5)ccc43)c3ccccc3)cc2)CC1 CHEMBL4172546 IC50 9.3 nM
COc1ccc(N(C)c2ncnc3occ(C)c23)cc1 CHEMBL4250191 IC50 9.3 nM
COc1ccc2c(c1)CCCN2c1nc(C)nc2ccccc12 CHEMBL2420866 IC50 9.3 nM
COc1ccc(NC(=O)Nc2ccc(Oc3ncnc4ccn(C)c34)cc2Cl)cc1C(F)(F)F CHEMBL1254515 IC50 9.4 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccccc21 CHEMBL2430263 IC50 9.4 nM
Cc1cc(Oc2cc(NC(=O)C3CC3)ncn2)ncc1NC(=O)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL3955460 IC50 9.4 nM
Cc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ncc1NC(=O)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL3969955 IC50 9.4 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1F)Nc1cc(OC(F)(F)F)ccc1F CHEMBL3919838 IC50 9.4 nM
CNCc1cc(Oc2ccc3c(ccn3C(=O)Nc3cc(C4(C)CC4)on3)c2)ncn1 CHEMBL4097955 IC50 9.4 nM
COc1ccc(C(=O)Nc2ccc(OCCN3CCCC3)c(F)c2)c(-c2cccc(O)c2)c1O CHEMBL3397920 IC50 9.41 nM
COc1ccc(Cn2ncc(NC(=O)c3cc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)ccc3C)c2N)cc1 CHEMBL1684800 IC50 9.42 nM
N=C(C/C=C(\N)c1ccn2c(-c3cccc(NC(=O)NCC(F)(F)F)c3)cnc2c1)N1CCNCC1 CHEMBL3690388 IC50 9.45 nM
COc1cc2ncnc(Nc3cc(O)c(F)cc3F)c2cc1OC CHEMBL3775169 IC50 9.5 nM
Cc1cc(NC(=O)Nc2cc(F)cc(C(C)(F)F)c2)ccc1Oc1cc(NC(=O)C2CC2)ncn1 CHEMBL3892923 IC50 9.5 nM
CN1CCC(c2cc(NC(=O)Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3)cc(C(F)(F)F)c2)CC1 CHEMBL3968087 IC50 9.5 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1)Nc1ccc(F)c(OC(F)(F)F)c1 CHEMBL3963883 IC50 9.5 nM
Cc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1NC(=O)Nc1cc(F)cc(C(F)(F)F)c1 CHEMBL3904994 IC50 9.5 nM
Cc1cc(NC(=O)Nc2ccc(Cl)c(C(C)(F)F)c2)ccc1Oc1ccnc(NC(=O)C2CC2)c1 CHEMBL3954230 IC50 9.5 nM
Cc1ccc(C(=O)Nc2cccc3cccnc23)c(O)c1 CHEMBL1271616 IC50 9.6 nM
Nc1cccc(C(=O)c2ccc3c(/C=N/n4cccc4)n[nH]c3c2)c1 CHEMBL3969393 Ki 9.6 nM
Cn1c(CO)cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)c(Cl)c3)c21 CHEMBL1255098 IC50 9.7 nM
Cc1[nH]c2c(c1C(=O)NCCN1CCCC1)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430260 IC50 9.7 nM
Cc1cc(NS(=O)(=O)c2ccc(Nc3nncc4ccccc34)cc2)no1 CHEMBL3899216 IC50 9.7 nM
Nc1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(C(F)(F)F)c1 CHEMBL3932357 IC50 9.7 nM
O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ccc(N5CCCC(O)C5)nn4)ccn23)c1 CHEMBL3690492 IC50 9.73 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5cccc(Cl)c5)CC4)cc3F)n2)c1 CHEMBL3287317 IC50 9.8 nM
NS(=O)(=O)c1ccc(Nc2nncc3ccccc23)cc1 CHEMBL3926223 IC50 9.8 nM
Cc1cc(NC(=O)Nc2ccc(Cl)c(OC(F)(F)F)c2)ccc1Oc1cc(NC(=O)C2CC2)ncn1 CHEMBL3961936 IC50 9.8 nM
Cc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ncc1NC(=O)Nc1cc(C(C)(F)F)ccc1F CHEMBL3965770 IC50 9.8 nM
CC(F)(F)c1cccc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)c1 CHEMBL3921563 IC50 9.8 nM
O=C(Cn1c(=O)c2nncn2c2ccccc21)Nc1ccc(C(=O)NNC(=O)c2ccc([N+](=O)[O-])cc2)cc1 CHEMBL4871200 IC50 9.8 nM
COc1cc(-c2cc(NC(=O)Nc3cc(OCCCN(C)C)ccc3C)cc(OC)c2OC)ccc1/C(C)=N/O CHEMBL3220326 IC50 9.87 nM
O=C(Nc1cccc(Oc2cc(NC(=O)C3CC3)ncn2)c1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL3971161 IC50 9.9 nM
O=C(Nc1cc(NC2CC2)cc(C(F)(F)F)c1)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1 CHEMBL3916910 IC50 9.9 nM
CC(F)(F)c1cccc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2F)c1 CHEMBL3980939 IC50 9.9 nM
Cc1cc(NC(=O)Nc2cc(C(C)(F)F)ccc2F)ccc1Oc1ccnc(NC(=O)C2CC2)c1 CHEMBL3982896 IC50 9.9 nM