CCc1cc(NC(=O)Nc2ccc(-c3cnc(Nc4cc(N5CCN(CC)CC5)ncn4)s3)cc2)no1 CHEMBL4448433 IC50 0.02 nM
Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)cncc21 CHEMBL404366 pKi 0.1585 nM
CN[C@H]1CC2OC([C@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(O)=NC4 CHEMBL3975634 IC50 0.18 nM
Cc1cc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(N)c34)cc2)ccc1F CHEMBL273187 pKi 0.1995 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 0.21 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 0.25 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL373798 pKi 0.2512 nM
COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1 CHEMBL491473 Kd 0.27 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cncc4c3c(N)nn4C)cc2)c1 CHEMBL402846 pKi 0.3162 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cncc4[nH]nc(N)c34)cc2)c1 CHEMBL272938 pKi 0.3162 nM
COCCOc1cc2ncnc(N3CCN(c4ncc(Cc5ccccc5)cn4)CC3)c2cc1OCCOC CHEMBL4205999 Kd 0.4 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 Kd 0.43 nM
COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1 CHEMBL1908396 Kd 0.46 nM
CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL1289926 Kd 0.49 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cncc4[nH]nc(N)c34)cc2)c1 CHEMBL271441 pKi 0.5012 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL5416410 Kd 0.57 nM
CCN1CCC(Oc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1 CHEMBL2203434 Kd 0.6 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)c(F)c3)c12 CHEMBL2000652 pKi 0.7943 nM
Cc1cc(NC(=O)Nc2ccc(-c3c(F)ccc4[nH]nc(N)c34)cc2)ccc1F CHEMBL1993996 pKi 0.7943 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4c3c(N)nn4C)cc2)c1 CHEMBL1985491 pKi 0.7943 nM
Cc1cc(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)c(F)c2)ccc1F CHEMBL1986979 pKi 0.7943 nM
Nc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL403402 pKi 0.7943 nM
Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)ccnc21 CHEMBL1985888 pKi 0.7943 nM
Cc1cc(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)ccc1F CHEMBL374044 pKi 0.7943 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ncccc3O)cc2)no1 CHEMBL1079545 Kd 0.96 nM
CC(=O)Nc1cc(CNc2ccccc2C(=O)Nc2ccc3c(c2)OC(F)(F)O3)ccn1 CHEMBL248256 IC50 1.0 nM
Nc1cc(CNc2ccccc2C(=O)Nc2ccc3c(c2)OC(F)(F)O3)ccn1 CHEMBL400109 IC50 1.0 nM
Cc1ccn(CCC2CCCC2)c(=O)c1-c1ccc2nc(N)ncc2c1 CHEMBL494821 IC50 1.0 nM
Nc1ncc(NC(=O)c2c(Cl)ccc3c(Nc4cccc(C(F)(F)F)c4)noc23)cn1 CHEMBL488984 IC50 1.0 nM
CC(=O)Nc1ccc(NC(=O)c2c(Cl)ccc3c(Nc4cccc(C(F)(F)F)c4)noc23)cn1 CHEMBL490823 IC50 1.0 nM
Cc1c(/C=C2\C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)N(CCN(C)C)CC2 CHEMBL1278234 IC50 1.0 nM
Cc1c(/C=C2\C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)N(CCN1CCOCC1)CC2 CHEMBL1276891 IC50 1.0 nM
Cc1c(/C=C2\C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)N(C[C@H](O)CN1CCOCC1)CC2 CHEMBL1276980 IC50 1.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)c1 CHEMBL1967116 pKi 1.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3c(F)ccc4[nH]nc(N)c34)cc2)c1 CHEMBL1996255 pKi 1.0 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc1)CCN2 CHEMBL260092 pKi 1.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)c(F)c2)c1 CHEMBL1994638 pKi 1.0 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(-c3ccnc4c3c(N)nn4C)cc2)c1 CHEMBL1986507 pKi 1.0 nM
CCN1C(C)(C)CC(Oc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1(C)C CHEMBL2206278 Kd 1.0 nM
Nc1ccc2ncnc(Nc3ccc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)cc3)c2c1 CHEMBL2403879 IC50 1.0 nM
O=C(Nc1ccc(Nc2ncnc3ccccc23)cc1)Nc1cccc(Br)c1 CHEMBL3628797 IC50 1.0 nM
O=C(Nc1ccc(Nc2ncnc3sccc23)cc1)Nc1cccc(Br)c1 CHEMBL3628798 IC50 1.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 IC50 1.0 nM
COCCOc1cc(F)c2c(Nc3ccc(NC(=O)Cn4cc(C(C)C)nn4)cc3)ncnc2c1 CHEMBL4216473 GI50 1.0 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL941 GI50 1.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Cc4cccc(C(F)(F)F)c4)cc3)c2cc1OC CHEMBL4585982 GI50 1.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(C(F)(F)F)c4)cc3)c2cc1OC CHEMBL4577779 GI50 1.0 nM
CNC(=O)c1cc(COc2nnc(Nc3ccc(Cl)cc3)c3ccoc23)ccn1 CHEMBL2079588 IC50 1.0 nM
CN1C(C)(C)CC(Oc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1(C)C CHEMBL2206277 Kd 1.1 nM
CN(C)c1ccc2c(Oc3ccc(NC(=O)NCc4ccc(C(F)(F)F)nc4)cc3)ncnc2c1 CHEMBL4847875 IC50 1.1 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cn[nH]c5)cnc(N)c34)cc2)c1 CHEMBL1969102 pKi 1.259 nM
CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc21 CHEMBL572881 Kd 1.3 nM
Cc1[nH]c2c(c1C(=O)NCCO)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430262 IC50 1.4 nM
CCCCCCNC(=O)Nc1ccc(-c2ccnc3[nH]nc(C)c23)cc1 CHEMBL4074755 IC50 1.4 nM
COc1ccc(NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2ccc[nH]2)cc1 CHEMBL1173149 IC50 1.5 nM
Cc1nc(-c2ccc(CNc3cc(-c4cnc5cc(OCCO)ccn45)ncn3)cc2)co1 CHEMBL4860486 IC50 1.5 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CCO)c5)cnc(N)c34)cc2)cc1 CHEMBL1977148 pKi 1.585 nM
Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4ccc(F)c(C(F)(F)F)c4)cc3)ccnc21 CHEMBL1966836 pKi 1.585 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(-c3cccc4onc(N)c34)cc2)c1 CHEMBL409349 pKi 1.585 nM
COc1ccc(-c2ccc(NC(=O)Nc3ccc(OC(F)(F)F)cc3)cc2)c2c(N)noc12 CHEMBL1973178 pKi 1.585 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCOCC5)ccc34)cc2)no1 CHEMBL576982 Kd 1.6 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 1.6 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1ccn2ccnc2c1 CHEMBL4093459 IC50 1.6 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL223360 Kd 1.7 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1171837 IC50 1.7 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)NCCCc4ccccc4)cc3)c12 CHEMBL4101428 IC50 1.7 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc4ccccc4cn3)cc2)no1 CHEMBL1081509 Kd 1.8 nM
Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O CHEMBL477772 Kd 1.8 nM
COc1cccc(NC(=O)c2ccc(C)c(C#Cc3cnc4ccnn4c3)c2)c1 CHEMBL2336040 IC50 1.9 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cnc5ccccc5c4)cc3)c12 CHEMBL4091975 IC50 1.9 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc(N)nc1 CHEMBL4101206 IC50 1.9 nM
Cn1cc(-c2cnn3c(N)c(-c4ccc(NC(=O)Nc5cccc(C(F)(F)F)c5)cc4)cnc23)cn1 CHEMBL1988717 pKi 1.995 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)c(F)c2)c1 CHEMBL1988778 pKi 1.995 nM
NC(=O)c1cc(CNc2ccccc2C(=O)Nc2ccc3c(c2)OC(F)(F)O3)ccn1 CHEMBL248051 IC50 2.0 nM
Nc1ccc(NC(=O)c2c(Cl)ccc3c(Nc4cccc(C(F)(F)F)c4)noc23)cn1 CHEMBL523816 IC50 2.0 nM
CC(=O)Nc1ccc(NC(=O)c2cc(C(=O)Nc3cccc(C(F)(F)F)c3)ccc2C)cn1 CHEMBL487864 IC50 2.0 nM
CCN(CC)CCN1CCc2[nH]c(/C=C3\C(=O)Nc4ccc(F)cc43)c(C)c2C1=O CHEMBL1278146 IC50 2.0 nM
COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C(F)(F)F)on4)c3)c2cc1OC CHEMBL2029988 Kd 2.0 nM
Cc1[nH]c2c(c1C(=O)NCCN1CCOCC1)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430258 IC50 2.0 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1ccc(N)nc1 CHEMBL4103644 IC50 2.0 nM
COc1cc(F)c2c(Nc3ccc(NC(=O)Cn4cc(C(C)C)nn4)cc3)ncnc2c1 CHEMBL4211506 GI50 2.0 nM
O=C(CC(=O)Nc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL4459467 GI50 2.0 nM
Cc1ccn(-c2ccc(C(C)(C)C)cc2)c(=O)c1-c1ccc2nc(N)ncc2c1 CHEMBL496494 IC50 2.1 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 2.1 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 2.1 nM
Cc1[nH]c2c(c1C(=O)N1CCOCC1)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430251 IC50 2.1 nM
COc1ccc(-c2cnc3[nH]cc(-c4ccc(OC)c(OC)c4)c3c2)cc1OC CHEMBL3102948 IC50 2.1 nM
Cc1cccc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(C)c34)cc2)c1 CHEMBL4103605 IC50 2.1 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc(N)c(C)c1 CHEMBL4076193 IC50 2.1 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cccnc1 CHEMBL1784625 IC50 2.1 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(F)cc5)c(=O)c5ccccc45)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3309402 IC50 2.17 nM
Cc1cccc(C(=O)Nc2cccc([C@H](C)Nc3cncc(Cl)n3)c2)c1 CHEMBL504075 Kd 2.2 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4cc(C#N)cs4)n[nH]3)cc2)CC1 CHEMBL4473820 Kd 2.2 nM
c1ccn2c(-c3cc(NCc4ccc(-n5cccn5)cc4)ncn3)cnc2c1 CHEMBL4878220 IC50 2.2 nM
COCCN1CCC(COc2ccn3c(-c4cc(NCc5ccc(-c6cnn(C)n6)cc5)ncn4)cnc3c2)CC1 CHEMBL4852385 IC50 2.2 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 2.3 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(Br)cc21 CHEMBL2430265 IC50 2.3 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(F)c2)cc1C#Cc1cccnc1 CHEMBL4097771 IC50 2.3 nM
Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(-c3ccccc3F)nncc2c1 CHEMBL1088796 Kd 2.4 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2180602 IC50 2.4 nM
Cc1cc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(C)c34)cc2)ccc1N1CCOCC1 CHEMBL4072731 IC50 2.4 nM
Cc1cccc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(CO)c34)cc2)c1 CHEMBL4083050 IC50 2.4 nM
COc1cc2c(Oc3ccc(NC(=O)c4nc5ccccc5n(-c5ccc(F)cc5)c4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4082724 IC50 2.45 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 2.5 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1ccn2cnnc2c1 CHEMBL4085713 IC50 2.5 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)c(F)c3)c12 CHEMBL1980904 pKi 2.512 nM
CN(C)CCCC(=O)Nc1ccc2ncnc(Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(N)c4)cc3)c2c1 CHEMBL2403819 IC50 2.6 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cccc(N(C)C)c4)cc3)c12 CHEMBL4064941 IC50 2.6 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)cc2)cc1C#Cc1cnc(N)nc1 CHEMBL4070641 IC50 2.6 nM
COc1cc2c(Oc3ccc(Nc4nn(C)cc4C(=O)NC4CCCCC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL5197792 Kd 2.6 nM
Cc1ccc(NC(=O)c2ccc(C)c(C#Cc3cnc4ccnn4c3)c2)cc1 CHEMBL2336035 IC50 2.61 nM
COc1cc2c(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCCN1CCCCC1 CHEMBL124660 Kd 2.7 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 2.7 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(Cl)cc21 CHEMBL2430264 IC50 2.7 nM
Cn1ncc(-c2ccc(CNc3cc(-c4cnc5cc(OCCCN6CCCC6)ccn45)ncn3)cc2)n1 CHEMBL4846747 IC50 2.8 nM
Cc1nc(Nc2nc3ccc(-c4cccc(C(=O)Nc5cccc(C(F)(F)F)c5)c4)nc3s2)cc(N2CCNCC2)n1 CHEMBL2148120 Kd 2.9 nM
CNC(=O)c1cc(CNc2ccsc2C(=O)Nc2ccc3c(c2)OC(F)(F)O3)ccn1 CHEMBL247618 IC50 3.0 nM
CNc1cc(CNc2ccccc2C(=O)Nc2ccc3c(c2)OC(F)(F)O3)ccn1 CHEMBL399534 IC50 3.0 nM
CNc1nccc(CNc2ccccc2C(=O)Nc2ccc3c(c2)OC(F)(F)O3)n1 CHEMBL246424 IC50 3.0 nM
O=C(Nc1cccnc1)c1c(Cl)ccc2c(Nc3cccc(C(F)(F)F)c3)noc12 CHEMBL489196 IC50 3.0 nM
O=C(Nc1cncnc1)c1c(Cl)ccc2c(Nc3cccc(C(F)(F)F)c3)noc12 CHEMBL491429 IC50 3.0 nM
Cc1c(/C=C2\C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)N(CCN1CCCC1)CC2 CHEMBL1276890 IC50 3.0 nM
COc1cc2ncnc(Nc3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c2cc1OC CHEMBL3628796 IC50 3.0 nM
CC(=O)Nc1cc(Oc2ccc3c(c2)nc(Nc2cccc(C(C)(C)C)c2)n3C)ccn1 CHEMBL3335371 IC50 3.0 nM
Cc1ccc(-c2noc(COC3CC(F)(F)C3(F)F)n2)cc1NC(=O)c1cnc2ccccn12 CHEMBL3904897 IC50 3.0 nM
COc1cc2ncnc(Oc3ccc(NC(=O)Cn4cc(C(C)C)nn4)cc3)c2cc1OC CHEMBL4214769 GI50 3.0 nM
COc1cc(OC)c2c(Nc3ccc(NC(=O)Cn4cc(C(C)C)nn4)cc3)ncnc2c1 CHEMBL4206522 GI50 3.0 nM
CCn1c(=O)c(-c2cc(NC(=O)Nc3ccccc3)c(F)cc2Br)cc2cnc(NC)cc21 CHEMBL4216467 GI50 3.0 nM
Cc1cccc(NC(=O)c2ccc(C)c(C#Cc3cnc4ccnn4c3)c2)c1 CHEMBL2331602 IC50 3.03 nM
COc1ccc(NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]cc(C(=O)O)c2C)cc1 CHEMBL1173411 IC50 3.1 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN5CCOCC5)cnc(N)c34)cc2)c1 CHEMBL1982465 pKi 3.162 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)(C)O)c5)cnc(N)c34)cc2)cc1 CHEMBL2004290 pKi 3.162 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)csc12 CHEMBL2005631 pKi 3.162 nM
COc1ccc(NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]c(C)c(C(=O)O)c2C)cc1 CHEMBL1173174 IC50 3.3 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4ccccc34)cc2)n(-c2cccc(N)c2)n1 CHEMBL2403816 IC50 3.3 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)cc2)cc1C#Cc1cccnc1 CHEMBL4092478 IC50 3.3 nM
COCCNc1ncc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(C)CC4)c(C(F)(F)F)c3)ccc2C)cn1 CHEMBL4077510 IC50 3.3 nM
Cn1ncc(-c2ccc(CNc3cc(-c4cnc5cc(OCCN6CC7(COC7)C6)ccn45)ncn3)cc2)n1 CHEMBL4861069 IC50 3.3 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3946811 IC50 3.38 nM
CC1CCN(c2cc(N3CCN(C)CC3)ccc2NC(=O)c2cc(C#N)c[nH]2)CC1 CHEMBL254702 IC50 3.5 nM
Cc1cn(-c2cc(F)cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)c2)cn1 CHEMBL2311807 Kd 3.5 nM
CN1CCN(CCC(=O)Nc2ccc3ncnc(Nc4ccc(NC(=O)Nc5cc(C(C)(C)C)nn5-c5cccc(N)c5)cc4)c3c2)CC1 CHEMBL2403820 IC50 3.5 nM
CCCCCNC(=O)Nc1ccc(-c2ccnc3[nH]nc(C)c23)cc1 CHEMBL4063380 IC50 3.5 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1ccccn1 CHEMBL4074329 IC50 3.5 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cccc5ccccc45)cc3)c12 CHEMBL4099718 IC50 3.6 nM
CCc1cccc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(CO)c34)cc2)c1 CHEMBL4059958 IC50 3.7 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)NCCc4ccccc4)cc3)c12 CHEMBL4100492 IC50 3.7 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5C(F)(F)F)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL2385195 IC50 3.9 nM
CCc1cccc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(C)c34)cc2)c1 CHEMBL4074518 IC50 3.9 nM
COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(-c5cnn(C)c5)cc4c3N(C)C2=O)c1F CHEMBL4871581 IC50 3.9 nM
COc1cc2c(N3CCN(C(=O)Nc4ccc(C#N)cc4)CC3)ncnc2cc1OCCCN1CCC(C)CC1 CHEMBL445636 IC50 4.0 nM
CCNC(=O)Nc1ccc(CNc2ncsc2C(=O)Nc2ccc3c(c2)OC(F)(F)O3)cn1 CHEMBL247798 IC50 4.0 nM
O=C(Nc1ccc2c(c1)OC(F)(F)O2)c1ccccc1NCc1ccnc(NCCOCCO)c1 CHEMBL247423 IC50 4.0 nM
COc1cccc(NC(=O)Nc2ccc(-c3cccc4onc(N)c34)cc2)c1 CHEMBL269894 IC50 4.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1N1Cc2cnc(N)nc2N(C)C1=O CHEMBL459850 EC50 4.0 nM
CC(=O)Nc1ncc(NC(=O)c2c(Cl)ccc3c(Nc4cccc(C(F)(F)F)c4)noc23)cn1 CHEMBL488985 IC50 4.0 nM
O=C(Nc1cncnc1)c1c(Cl)ccc2c(Nc3cccc(OC(F)(F)F)c3)noc12 CHEMBL484885 IC50 4.0 nM
CCN(CC)CCN1CCc2[nH]c(/C=C3\C(=O)Nc4ccc(Cl)cc43)c(C)c2C1=O CHEMBL1278147 IC50 4.0 nM
CCN(CC)CCN1CCc2[nH]c(/C=C3\C(=O)Nc4ccc(Br)cc43)c(C)c2C1=O CHEMBL1278233 IC50 4.0 nM
CCN(CC)CCN1CCCc2[nH]c(/C=C3\C(=O)Nc4ccc(F)cc43)c(C)c2C1=O CHEMBL1276981 IC50 4.0 nM
Cc1c(/C=C2\C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)N(CCN1CCOCC1)CCC2 CHEMBL1277071 IC50 4.0 nM
Nc1nc(Nc2ccc([C@H]3CC[C@H](N4CCOCC4)CC3)cc2)nn1-c1ccccn1 CHEMBL1835870 IC50 4.0 nM
CN1CCC(c2ccc(Nc3nc(N)n(-c4ccccn4)n3)cc2)CC1 CHEMBL1835867 IC50 4.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC CHEMBL2105717 IC50 4.0 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc(N)c2ccccc12 CHEMBL4100222 IC50 4.0 nM
COc1cc2ncnc(Oc3ccc(CC(=O)Nc4cnn(C(C)C)c4)cc3)c2cc1OC CHEMBL1940274 GI50 4.0 nM
CCC(=O)NCC1CCN(c2ccc(NC(=O)Nc3cccc(Oc4ccnc5cc(OC)c(OC)cc45)c3)cc2C(F)(F)F)CC1 CHEMBL4445808 GI50 4.0 nM
Cn1cc(-c2ccc(CNc3cc(-c4cnc5cc(OCCCN6CCCC6)ccn45)ncn3)cc2)cn1 CHEMBL5314917 IC50 4.0 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccc(F)cc5)c4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3343366 IC50 4.02 nM
CCN(CC)CC(O)CNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430250 IC50 4.1 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(C)cc21 CHEMBL2430266 IC50 4.1 nM
COCC/C(=N\S(=O)(=O)Cc1ccc(Cl)cc1)Nc1ccc(Oc2ccnc3cc(OCCCN4CCOCC4)c(OC)cc23)c(F)c1 CHEMBL4799113 IC50 4.26 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5C(F)(F)F)c(=O)cc4C)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL3290931 IC50 4.32 nM
Cc1cn(-c2cccc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)c2)cn1 CHEMBL2311808 Kd 4.4 nM
COc1ccn2c(-c3cc(NCc4ccc(-c5cnn(C)n5)cc4)ncn3)cnc2c1 CHEMBL4854815 IC50 4.4 nM
COc1cc2nccc(Oc3ccc(NC(=O)C(OC(=O)c4ccc(F)cc4)C(C)(C)C)cc3F)c2cc1OC CHEMBL4779315 IC50 4.42 nM
COc1ccc(NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]c(C)c(CCC(=O)O)c2C)cc1 CHEMBL1173541 IC50 4.5 nM
O=C(Nc1ccc(Nc2ncnc3ccc([N+](=O)[O-])cc23)cc1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL2403878 IC50 4.5 nM
COc1cc(-c2cnc3c(N4CCOCC4)snc3c2)ccc1N CHEMBL3425867 Kd 4.5 nM
COc1ccn2c(-c3cc(NCc4ccc(-c5ccccc5)cc4)ncn3)cnc2c1 CHEMBL5406320 IC50 4.6 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nc(-c2cccnc2)cs1 CHEMBL1908391 Kd 4.7 nM
Cc1ccc(C(=O)Nc2cccc(Cl)c2)cc1C#Cc1cnc2ccnn2c1 CHEMBL2336037 IC50 4.89 nM
Cc1cccc(NC(=O)Nc2ccc(-c3ccc(F)c4[nH]nc(N)c34)cc2)c1 CHEMBL374752 IC50 5.0 nM
CNC(=O)Nc1ccc(CNc2ncsc2C(=O)Nc2ccc3c(c2)OC(F)(F)O3)cn1 CHEMBL247250 IC50 5.0 nM
CNC(=O)Nc1cc(CNc2ccccc2C(=O)Nc2ccc3c(c2)OC(F)(F)O3)ccn1 CHEMBL394503 IC50 5.0 nM
CNC(=O)c1cc(CNc2ccccc2C(=O)Nc2ccc3c(c2)OC(F)(F)O3)ccn1 CHEMBL247437 IC50 5.0 nM
COc1ccc(NC(=O)Nc2ccc(-c3cccc4onc(N)c34)cc2)cc1 CHEMBL269885 IC50 5.0 nM
Cc1ccc(NC(=O)Nc2ccc(-c3cccc4onc(N)c34)cc2)cc1 CHEMBL272645 IC50 5.0 nM
CC(C)(C)c1cccc(Nc2noc3c(C(=O)Nc4cncnc4)c(Cl)ccc23)c1 CHEMBL519520 IC50 5.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1C(=O)Nc1cnc(N)nc1 CHEMBL272902 IC50 5.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908842 IC50 5.0 nM
CC(C)(N)CC(=O)N1CCC(c2ccc(NC(=O)c3ncc(C#N)[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL2158300 IC50 5.0 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)csc12 CHEMBL1982476 pKi 5.012 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cnc4c(-c5cnn(C)c5)cnn4c3N)cc2)c1 CHEMBL508928 pKi 5.012 nM
CCCn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1993941 pKi 5.012 nM
Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1 CHEMBL101253 Kd 5.1 nM
O=C(Nc1ccccc1)Nc1ccc2c(c1)NC(=O)/C2=C\c1ccc[nH]1 CHEMBL1173482 IC50 5.1 nM
CN1CC(COc2ccn3c(-c4cc(NCc5ccc(-c6cnn(C)c6)cc5)ncn4)cnc3c2)C1 CHEMBL4871511 IC50 5.1 nM
c1ccn2c(-c3cc(NCc4ccc(N5CCCC5)nc4)ncn3)cnc2c1 CHEMBL5417135 IC50 5.4 nM
c1ccn2c(-c3nccc(NCc4ccc(N5CCCC5)cc4)n3)cnc2c1 CHEMBL5420504 IC50 5.6 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4ccc(NC(=O)CCN5CCOCC5)cc34)cc2)n(-c2cccc(N)c2)n1 CHEMBL2403821 IC50 5.7 nM
Cc1[nH]c2c(c1C(=O)NCCCN1CCOCC1)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430248 IC50 5.7 nM
Cc1[nH]c2c(c1C(=O)NCCN1CCCCC1)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430259 IC50 5.8 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1ccc(N)nn1 CHEMBL4075321 IC50 5.8 nM
COc1cc2c(N3CCN(C(=O)Nc4ccc(C#N)cc4)CC3)ncnc2cc1OCCCN1CCCCC1C CHEMBL126699 IC50 6.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)c1 CHEMBL196363 IC50 6.0 nM
CONC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(C4CCN(C)CC4)cc3)ncc2c1=O CHEMBL492809 IC50 6.0 nM
CONC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O CHEMBL505830 IC50 6.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4ccccc4)ccc32)c(C)c1C(=O)O CHEMBL1173107 IC50 6.0 nM
O=C(Nc1ccc(Nc2ncnc3sc4c(c23)CCCC4)cc1)Nc1cccc(Br)c1 CHEMBL3628799 IC50 6.0 nM
Cc1ccc(-c2noc(C3CC(F)(F)C3)n2)cc1NC(=O)c1cnc2ccc(-c3cnn(CC(C)(C)O)c3)cn12 CHEMBL3914373 IC50 6.0 nM
COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1CC(=O)Nc1cnn(C(C)C)c1 CHEMBL4217419 GI50 6.0 nM
COCCNCc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)C5(C(=O)Nc6ccc(F)cc6)CC5)cc4F)c3s2)nc1 CHEMBL3989926 IC50 6.0 nM
COC(=O)c1ccc2c(C(Nc3ccc(N(C)C(=O)CN4CCN(C)CC4)cc3)c3ccccc3)c(O)[nH]c2c1 CHEMBL5201102 IC50 6.0 nM
Cc1ccn(-c2ccc3c(c2)NCC3(C)C)c(=O)c1-c1ccc2nc(N)ncc2c1 CHEMBL493986 IC50 6.1 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4ccc(N)cc34)cc2)n(-c2cccc(N)c2)n1 CHEMBL2403815 IC50 6.1 nM
COCCN1CCN(C(C)(C)c2ccc(NC(=O)c3ncc(C#N)[nH]3)c(C3=CCC(C)(C)CC3)c2)CC1 CHEMBL3085834 IC50 6.1 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1 CHEMBL1946170 IC50 6.1 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)NCCCCc4ccccc4)cc3)c12 CHEMBL4074745 IC50 6.2 nM
Cc1c(C#Cc2cnc(N)nc2)cccc1C(=O)Nc1ccc(CN2CCN(C)CC2)c(C(F)(F)F)c1 CHEMBL4090058 IC50 6.2 nM
COc1ccc(-c2c[nH]c3ncc(-c4cccc(N)c4)cc23)cc1OC CHEMBL2152262 IC50 6.3 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(F)c2)cc1C#Cc1cnc(N)nc1 CHEMBL4062017 IC50 6.5 nM
Cn1cc(-c2ccc(CNc3cc(-c4cnc5cc(OCCN6CCC[C@@H]7OCC[C@@H]76)ccn45)ncn3)cc2)cn1 CHEMBL4872031 IC50 6.5 nM
Cc1[nH]c2c(c1C(=O)NCCN(C)C)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430261 IC50 6.6 nM
COc1cccnc1C#Cc1cc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)ccc1C CHEMBL4092506 IC50 6.7 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1I CHEMBL4079252 IC50 6.8 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc([N+](=O)[O-])cc21 CHEMBL2430254 IC50 6.9 nM
N=C(N)c1ccc(/N=N/c2c(N)ncc3ccc(Br)cc23)cc1 CHEMBL4091670 IC50 6.9 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3nsc4ncnc(N)c34)cc2)c1 CHEMBL262433 IC50 7.0 nM
CCNC(=O)Nc1cc(CNc2ccccc2C(=O)Nc2ccc3c(c2)OC(F)(F)O3)ccn1 CHEMBL247793 IC50 7.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cncc4c3c(N)nn4C)cc2)c1 CHEMBL404367 IC50 7.0 nM
Nc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)c12 CHEMBL255955 IC50 7.0 nM
Nc1noc2cccc(-c3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c12 CHEMBL406660 IC50 7.0 nM
Nc1noc2cccc(-c3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c12 CHEMBL272802 IC50 7.0 nM
CCCc1ccc(Nc2noc3c(C(=O)Nc4cncnc4)c(Cl)ccc23)cc1 CHEMBL489786 IC50 7.0 nM
CCc1ccc(Nc2noc3c(C(=O)Nc4cncnc4)c(Cl)ccc23)cc1 CHEMBL489579 IC50 7.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1C(=O)Nc1ccc(N)nc1 CHEMBL470483 IC50 7.0 nM
Oc1ccc(-c2ccc3c(-c4ccc(N5CCNCC5)cc4)n[nH]c3n2)cc1 CHEMBL1910893 IC50 7.0 nM
Cc1ccc(-c2noc(C3CC(F)(F)C3)n2)cc1NC(=O)c1cnc2ccccn12 CHEMBL3909005 IC50 7.0 nM
Cc1ccc(-c2noc(C3CC(F)(F)C3)n2)cc1NC(=O)c1cnc2ccc(-c3cnn(C)c3)cn12 CHEMBL3915093 IC50 7.0 nM
Cc1ccc(-c2noc(C3CC(F)(F)C3)n2)cc1NC(=O)c1cnc2cc(N3CCOCC3)ccn12 CHEMBL3964322 IC50 7.0 nM
COc1cc(OC)c2c(Oc3ccc(NC(=O)Cn4cc(C(C)C)nn4)cc3)ncnc2c1 CHEMBL4218252 GI50 7.0 nM
CCn1cc(NC(=O)Cc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)cn1 CHEMBL1940272 GI50 7.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Cc4cnn(C(C)C)c4)cc3)c2cc1OC CHEMBL4206694 GI50 7.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 7.1 nM
O=C(Nc1ccc(-c2ccccc2)cc1)Nc1ccc2c(c1)NC(=O)/C2=C\c1ccc[nH]1 CHEMBL1172837 IC50 7.2 nM
Cc1cc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(C)c34)cc2)ccc1N1CCN(C)CC1 CHEMBL4066302 IC50 7.2 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4ccccc34)cc2)n(-c2cccc([N+](=O)[O-])c2)n1 CHEMBL2403814 IC50 7.3 nM
COCCOc1ccn2c(-c3cc(NCc4ccc(-c5cnn(C)c5)cc4)ncn3)cnc2c1 CHEMBL5403975 IC50 7.3 nM
Cc1[nH]c2c(c1C(=O)NCCN1CCCC1)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430260 IC50 7.4 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cn4c(n3)sc3ccccc34)cc2)no1 CHEMBL575925 Kd 7.5 nM
CCC(=O)Nc1ccc2ncnc(Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4cccc(N)c4)cc3)c2c1 CHEMBL2403818 IC50 7.6 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 7.7 nM
Cc1[nH]c2c(c1C(=O)N1CCC(N3CCCCC3)CC1)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430252 IC50 7.8 nM
Cc1ccn(-c2ccc(C(F)(F)F)cc2)c(=O)c1-c1ccc2nc(N)ncc2c1 CHEMBL498557 IC50 7.9 nM
CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1 CHEMBL215152 Kd 7.9 nM
CNC(=O)C(C)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(C)cc5)cc4)csc23)cn1 CHEMBL1970142 pKi 7.943 nM
CCOc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)cc1 CHEMBL1974254 pKi 7.943 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)cc1 CHEMBL1982466 pKi 7.943 nM
O=C(Nc1ccc2c(c1)OC(F)(F)O2)c1ccccc1NCc1ccnc(NCCO)c1 CHEMBL398052 IC50 8.0 nM
CC(C)(C)c1ccc(Nc2noc3c(C(=O)Nc4cncnc4)c(Cl)ccc23)cc1 CHEMBL490407 IC50 8.0 nM
Cc1c(/C=C2\C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)N(C[C@H](O)CN1CCOCC1)CCC2 CHEMBL1277072 IC50 8.0 nM
N#Cc1cnc(C(=O)Oc2ccc(C3CCN(C(=O)[C@H](O)CO)CC3)cc2C2=CCCCC2)[nH]1 CHEMBL3680625 IC50 8.0 nM
COc1cc(Oc2ncnc3cc(OC)c(OC)cc23)ccc1CC(=O)Nc1cnn(C(C)C)c1 CHEMBL4212563 GI50 8.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Cc4cnn(C(C)C)c4)nc3)c2cc1OC CHEMBL4209280 GI50 8.0 nM
Cn1cc(-c2cc3c(N4CCN(c5ncc([C@@](C)(N)c6ccc(F)cc6)cn5)CC4)ncnn3c2)cn1 CHEMBL4204794 GI50 8.0 nM
O=C(CC(=O)Nc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1)Nc1cccc(F)c1 CHEMBL4446361 GI50 8.0 nM
CCCCNc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL3326006 IC50 8.18 nM
Cc1[nH]c2c(c1C(=O)N1CCC[C@H]1CN1CCCC1)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430253 IC50 8.5 nM
COc1ccc(-c2c[nH]c3ncc(-c4ccc(C(=O)N5CCOCC5)c(N)c4)cc23)cc1OC CHEMBL3319467 IC50 8.5 nM
Cc1ccc(NC(=O)c2ccc3c(c2)CC[C@@H]3N2CCN(C)CC2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL3690082 IC50 8.5 nM
COc1ccn2c(-c3cc(NCc4ccc(-c5cnn(C)c5)cc4)ncn3)cnc2c1 CHEMBL4849258 IC50 8.6 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)NC4Cc5ccccc5C4)cc3)c12 CHEMBL4063368 IC50 8.7 nM
COc1ccc(-c2c[nH]c3ncc(-c4cc(OC)c(OC)c(OC)c4)cc23)cc1OC CHEMBL3319468 IC50 8.8 nM
Cc1cccc(NC(=O)Nc2ccc(-c3c(C)sc4ncnc(N)c34)cc2)c1 CHEMBL371329 pIC50 8.913 nM
O=C(Nc1ccc2c(c1)OC(F)(F)O2)c1ccccc1NCc1ccnc(NCCCO)c1 CHEMBL395700 IC50 9.0 nM
O=C(Cn1cc(Nc2nncc3cc(OCCCN4CCC[C@@H]4CO)ccc23)cn1)Nc1cccc(F)c1F CHEMBL253968 IC50 9.0 nM
Cc1ccc(C(=O)NCCCC2CCCCC2)cc1C(=O)Nc1ccc(N)nc1 CHEMBL520718 IC50 9.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cnc4c(-c5cnn(C)c5)ccn4c3N)cc2)c1 CHEMBL453057 IC50 9.0 nM
O=C(Nc1ccc(Cl)cc1)Nc1ccc2c(c1)NC(=O)/C2=C\c1ccc[nH]1 CHEMBL1172886 IC50 9.0 nM
CCN(CC)CCN1CCCCc2[nH]c(/C=C3\C(=O)Nc4ccc(F)cc43)c(C)c2C1=O CHEMBL1277161 IC50 9.0 nM
COc1ccc(Nc2nc(N)n(-c3ccccn3)n2)cc1OC CHEMBL1835740 Ki 9.0 nM
CO[C@H]1C[C@@H](c2nc(-c3ccc(C)c(NC(=O)c4cnc5ccccn45)c3)no2)C1 CHEMBL3908289 IC50 9.0 nM
Cc1ccc(-c2noc(C3CC(F)(F)C3)n2)cc1NC(=O)c1cnc2ccc(-c3cn[nH]c3)cn12 CHEMBL3899039 IC50 9.0 nM
Cc1ccn2c(C(=O)Nc3cc(-c4noc(COC5CC(F)(F)C5(F)F)n4)ccc3C)cnc2c1 CHEMBL3943835 IC50 9.0 nM
COc1cc2ncnc(Oc3ccc(NC(=O)Cc4cc(C(C)C)n[nH]4)cc3)c2cc1OC CHEMBL4208854 GI50 9.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(C(F)(F)F)c4)cc3C)c2cc1OC CHEMBL4448468 GI50 9.0 nM
CC(OC(=O)c1ccc2nc(N)sc2c1)C(=O)Nc1ccc(C(C)(C)C)cc1 CHEMBL4752670 IC50 9.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL1240703 Kd 9.1 nM
COc1ccc(-c2c[nH]c3ncc(-c4ccc(N)cc4)cc23)cc1OC CHEMBL3319472 IC50 9.1 nM
COc1ccc(NC(=O)c2ccc(C)c(C#Cc3cnc4ccnn4c3)c2)cc1 CHEMBL2336018 IC50 9.28 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4ccc(N(C)C)cc4)cc3)c12 CHEMBL4084878 IC50 9.3 nM
COc1cc2c(Oc3ccc(NC(=O)c4cn(-c5ccccc5Cl)nn4)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL3823520 IC50 9.36 nM
COc1cc(O)c2c(c1)/C=C/C[C@@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O CHEMBL1668411 IC50 9.6 nM
Cc1ccc(CNC(=O)Nc2ccccc2)cc1NC(=O)c1cnc2ccccn12 CHEMBL3608785 IC50 9.8 nM
CCN(CC)CCCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430247 IC50 9.9 nM