CC1(Nc2nc(-c3ccnc4[nH]ccc34)nc3cnccc23)CC1 CHEMBL4571918 IC50 0.0 nM
CC(C)(N)C(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4439972 IC50 0.7 nM
Cc1n[nH]cc1-c1nc(NC(C)(C)CCN(C)C)c2ccncc2n1 CHEMBL4525078 IC50 0.8 nM
CC(C)(CN)CNc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4447153 IC50 0.8 nM
C[C@@H]1CCC[C@@H]1Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4463018 IC50 0.9 nM
CCN(CC)c1nc(-c2ccncc2)nc2cnccc12 CHEMBL4531857 IC50 1.0 nM
CC(C)(Nc1nc(-c2ccncc2)nc2cnccc12)C1CC1 CHEMBL4472285 IC50 1.0 nM
CCN(c1nc(-c2ccncc2)nc2cnccc12)C(C)C CHEMBL4472973 IC50 1.0 nM
CC(Nc1nc(-c2ccncc2)nc2cnccc12)C(F)(F)F CHEMBL4592699 IC50 1.0 nM
CC(C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4464251 IC50 1.0 nM
CC(C)(O)CC(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4533967 IC50 1.0 nM
CC(C)(Nc1nc(-c2ccncc2)nc2cnccc12)C(F)(F)F CHEMBL4571192 IC50 1.0 nM
CC(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4551441 IC50 1.0 nM
CC1(Nc2nc(-c3ccncc3)nc3cnccc23)CCC1 CHEMBL4467179 IC50 1.0 nM
CC(C)(CCO)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4518582 IC50 1.0 nM
FC(F)(F)C1(Nc2nc(-c3ccncc3)nc3cnccc23)CCC1 CHEMBL4577857 IC50 1.0 nM
CCC(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4472306 IC50 1.0 nM
FC(F)(F)C1(Nc2nc(-c3ccncc3)nc3cnccc23)CC1 CHEMBL4517252 IC50 1.0 nM
CC[C@H](C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4471884 IC50 1.0 nM
CC1(Nc2nc(-c3ccncc3)nc3cnccc23)CC1 CHEMBL4443335 IC50 1.0 nM
NCCCCCCNc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4577658 IC50 1.0 nM
CN(C)CCC(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4564805 IC50 1.0 nM
FC(F)(F)c1n[nH]cc1-c1nc(NC2CCCC2)c2ccncc2n1 CHEMBL4576185 IC50 1.0 nM
CC(C)(Nc1nc(-c2ccncc2F)nc2cnccc12)C(F)(F)F CHEMBL4555291 IC50 1.0 nM
CCCNc1nc(-c2c[nH]c3ncccc23)nc2cnccc12 CHEMBL4450447 IC50 1.0 nM
CC1(Nc2nc(-c3ccncc3)nc3c(Cl)nccc23)CC1 CHEMBL4450439 IC50 1.0 nM
Cc1nccc2c(NC3(C)CC3)nc(-c3ccncc3)nc12 CHEMBL4547932 IC50 1.0 nM
CC(C)(C)Nc1cc(-c2ccncc2)nc2cnccc12 CHEMBL4454440 IC50 1.0 nM
Cc1n[nH]cc1-c1cc(NC(C)(C)C)c2ccncc2n1 CHEMBL4444109 IC50 1.0 nM
CC1(Nc2cc(-c3ccncc3)nc3cnccc23)CCC1 CHEMBL4446217 IC50 1.2 nM
CN(c1cc(-c2ccncc2)nc2cnccc12)C(C)(C)C CHEMBL4590309 IC50 1.2 nM
CC(C)(CC(N)=O)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4456826 IC50 1.8 nM
CC1(Nc2cc(-c3ccncn3)nc3cnccc23)CCC1 CHEMBL4483764 IC50 1.9 nM
CC(C)N(C)c1nc(-c2ccncc2)nc2cnccc12 CHEMBL4558207 IC50 2.0 nM
COCC(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4471995 IC50 2.0 nM
CCCNc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4472817 IC50 2.0 nM
CC(N(C)c1nc(-c2ccncc2)nc2cnccc12)C(F)(F)F CHEMBL4439529 IC50 2.0 nM
C[C@H](N(C)c1nc(-c2ccncc2)nc2cnccc12)C(F)(F)F CHEMBL4572019 IC50 2.0 nM
c1cc(-c2nc(NC3CCCC3)c3ccncc3n2)ccn1 CHEMBL4547445 IC50 2.0 nM
CC(C)(CO)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4532021 IC50 2.0 nM
CC(CO)(Nc1nc(-c2ccncc2)nc2cnccc12)C(F)(F)F CHEMBL4514630 IC50 2.0 nM
CCC(C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4437570 IC50 2.0 nM
CC[C@@H](C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4462244 IC50 2.0 nM
CC(C)CNc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4436796 IC50 2.0 nM
CC(C)(CN)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4447080 IC50 2.0 nM
CC(C)(C)Nc1nc(-c2ccnc(N)c2)nc2cnccc12 CHEMBL4440182 IC50 2.0 nM
Cc1[nH]c2ncccc2c1-c1nc(NC(C)(C)C)c2ccncc2n1 CHEMBL4460905 IC50 2.0 nM
CC(C)(C)Nc1nc(-c2c[nH]nc2C(F)(F)F)nc2cnccc12 CHEMBL4592930 IC50 2.0 nM
Cc1n[nH]cc1-c1nc(NC2(C)CC2)c2ccncc2n1 CHEMBL4585067 IC50 2.0 nM
Cc1n[nH]cc1-c1nc(NC(C)(C)C(F)(F)F)c2ccncc2n1 CHEMBL4517907 IC50 2.0 nM
C[C@H](N(C)c1nc(-c2ccncc2F)nc2cnccc12)C(F)(F)F CHEMBL4563697 IC50 2.0 nM
CC1(Nc2nc(-c3ccnc(N)c3)nc3cnccc23)CC1 CHEMBL4591733 IC50 2.0 nM
CC1(Nc2nc(-n3ccc4ncccc43)nc3cnccc23)CC1 CHEMBL4529796 IC50 2.0 nM
CC1(Nc2nc(-c3ccncc3)nc3cncc(Cl)c23)CC1 CHEMBL4572928 IC50 2.0 nM
CC(C)(C)Nc1cc(-c2ccncn2)nc2cnccc12 CHEMBL4438081 IC50 2.0 nM
CC(C)(C)Nc1cc(-c2ccnc(N)n2)nc2cnccc12 CHEMBL4573735 IC50 2.0 nM
CC(C)(C)Nc1cc(-c2ccnc3[nH]ccc23)nc2cnccc12 CHEMBL4456799 IC50 2.0 nM
CCCNc1nc(-c2c[nH]nc2C(F)(F)F)nc2cnccc12 CHEMBL4565580 IC50 2.0 nM
CN(C)CCC(C)(C)Nc1nc(-c2c[nH]nc2C(F)(F)F)nc2cnccc12 CHEMBL4476463 IC50 2.3 nM
CC(C)(N)CNc1nc(-c2ccncc2)nc2cnccc12 CHEMBL3338837 IC50 2.4 nM
COCCC(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4470612 IC50 3.0 nM
CCCCN(C)c1nc(-c2ccncc2)nc2cnccc12 CHEMBL4591428 IC50 3.0 nM
CCN(C)c1nc(-c2ccncc2)nc2cnccc12 CHEMBL4447677 IC50 3.0 nM
CC(C)(COCCO)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4436873 IC50 3.0 nM
C[C@H]1CCC[C@H]1Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4463415 IC50 3.0 nM
C#CC(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4451115 IC50 3.0 nM
C[C@]1(Nc2nc(-c3ccncc3)nc3cnccc23)C[C@@H](O)C1 CHEMBL4463150 IC50 3.0 nM
NCCCCNc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4439149 IC50 3.0 nM
CC(C)(C)Nc1nc(-c2ccncc2Cl)nc2cnccc12 CHEMBL4520049 IC50 3.0 nM
CC(C)(Nc1nc(-c2ccncc2Cl)nc2cnccc12)C(F)(F)F CHEMBL4513243 IC50 3.0 nM
CC1(C)CC(O)CCN1c1cc(-c2ccncc2)nc2cnccc12 CHEMBL4436727 IC50 3.0 nM
CC(C)(C)Nc1cc(-c2ccncc2F)nc2cnccc12 CHEMBL4520021 IC50 3.0 nM
CN(C)CC(C)(C)CN(C)c1nc(-c2ccncc2)nc2cnccc12 CHEMBL4465820 IC50 3.0 nM
CCN(CC)CCC(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4436919 IC50 3.1 nM
CN(C)C(C)(C)CNc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4439805 IC50 3.7 nM
NCCNc1nc(-c2ccncc2)nc2cnccc12 CHEMBL2147535 IC50 3.8 nM
FC(F)(F)[C@@H]1CN(c2nc(-c3ccncc3)nc3cnccc23)CCN1 CHEMBL4476521 IC50 3.8 nM
CC(C)(O)COCC(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4574721 IC50 4.0 nM
CCNc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4446448 IC50 4.0 nM
CC(C)(Nc1nc(-c2ccncc2)nc2cnccc12)C1CCCCC1 CHEMBL4465888 IC50 4.0 nM
CC(C)(O)C(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4566869 IC50 4.0 nM
CC(C)(C)CC(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4578137 IC50 4.0 nM
CC(C)(CNC(=O)OC(C)(C)C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4461498 IC50 4.0 nM
Cc1cnccc1-c1nc(NC(C)(C)C)c2ccncc2n1 CHEMBL4462002 IC50 4.0 nM
Cc1n[nH]cc1-c1nc(NC(C)(C)CC(C)(C)O)c2ccncc2n1 CHEMBL4470043 IC50 4.0 nM
CC1(Nc2nc(-c3ccncc3C#N)nc3cnccc23)CC1 CHEMBL4533936 IC50 4.0 nM
Cn1nccc1-c1nc(NC(C)(C)C)c2ccncc2n1 CHEMBL4579119 IC50 4.0 nM
CC(C)(C)Nc1nc(-c2ccncc2)nc2cncc(Cl)c12 CHEMBL4444003 IC50 4.0 nM
CCC(C)(C)Nc1cc(-c2ccncc2F)nc2cnccc12 CHEMBL4554641 IC50 4.0 nM
FC(F)(F)C1(Nc2nc(-c3ccncc3)cc3cnccc23)CC1 CHEMBL4449036 IC50 4.0 nM
FC(F)(F)C1(Nc2cc(-c3ccncc3)cc3cnccc23)CC1 CHEMBL4447885 IC50 4.0 nM
FC(F)(F)C1CN(c2nc(-c3ccncc3)nc3cnccc23)CCN1 CHEMBL4522021 IC50 4.0 nM
FC(F)(F)C1(Nc2cc(-c3ccncc3)nc3cnccc23)CCC1 CHEMBL4464441 IC50 4.5 nM
CN(C)CC(C)(C)CNc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4468766 IC50 4.5 nM
CC1(Nc2nc(-c3ccncc3)nc3cnccc23)COC1 CHEMBL4450377 IC50 5.0 nM
CC1CCCC1Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4446730 IC50 5.0 nM
CC(C)(O)C(C)(Nc1nc(-c2ccncc2)nc2cnccc12)C(F)(F)F CHEMBL4562711 IC50 5.0 nM
OCC1(Nc2nc(-c3ccncc3)nc3cnccc23)CCC1 CHEMBL4529548 IC50 5.0 nM
CC(C)(CC#N)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4450536 IC50 5.0 nM
CCC(C)(C)Nc1nc(-c2ccncc2Cl)nc2cnccc12 CHEMBL4470520 IC50 5.0 nM
CC1(Nc2nc(-c3cn[nH]c3)nc3cnccc23)CC1 CHEMBL4472003 IC50 5.0 nM
COCCC(C)(C)Nc1cc(-c2ccncc2)nc2cnccc12 CHEMBL4458233 IC50 5.0 nM
CN(CCC(C)(C)N)c1nc(-c2ccncc2)nc2cnccc12 CHEMBL4472021 IC50 5.0 nM
CC(C)(CN)CNc1cc(-c2ccncc2)nc2cnccc12 CHEMBL4563473 IC50 5.2 nM
CC(O)C(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4562948 IC50 6.0 nM
CCCCNc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4577449 IC50 6.0 nM
CC(C)(CCc1ccccc1)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4438062 IC50 6.0 nM
C[C@@H](N(C)c1nc(-c2ccncc2)nc2cnccc12)C(F)(F)F CHEMBL4476180 IC50 6.0 nM
OCC1(Nc2nc(-c3ccncc3)nc3cnccc23)CCCC1 CHEMBL4583241 IC50 6.0 nM
CCC(CC)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4439340 IC50 6.0 nM
CC(C)(CN1CCOCC1)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4448758 IC50 6.0 nM
CCCNc1nc(-c2c(C)[nH]c3ncccc23)nc2cnccc12 CHEMBL4466285 IC50 6.0 nM
CCCNc1nc(-n2ccc3ncccc32)nc2cnccc12 CHEMBL4459333 IC50 6.0 nM
Cc1cnccc1-c1nc(NC(C)(C)C(F)(F)F)c2ccncc2n1 CHEMBL4446164 IC50 6.0 nM
CN(C)CCC(C)(C)Nc1nc(-c2ccnc(N)c2)nc2cnccc12 CHEMBL4566594 IC50 6.1 nM
c1cc(-c2nc(NC3CC3)c3ccncc3n2)ccn1 CHEMBL4457324 IC50 7.0 nM
CC(C)(CCS(C)(=O)=O)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4589113 IC50 7.0 nM
CC1(Nc2nc(-c3ccc4[nH]ncc4c3)nc3cnccc23)CC1 CHEMBL4546314 IC50 7.0 nM
CC(C)(O)CC(C)(C)Nc1cc(-c2ccncc2)nc2cnccc12 CHEMBL4461250 IC50 7.0 nM
c1cc(-c2cc(NC3CCCC3)c3ccncc3n2)ccn1 CHEMBL4442227 IC50 7.0 nM
CC1(Nc2cc(-c3ccncc3)nc3cnccc23)CC1 CHEMBL4566901 IC50 7.5 nM
Cc1n[nH]c(C)c1-c1nc(NC(C)(C)CCN(C)C)c2ccncc2n1 CHEMBL4459788 IC50 7.6 nM
CC(C)(COC(C)(C)C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4537258 IC50 8.0 nM
CC(C)(C#N)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4453593 IC50 8.0 nM
CC1(Nc2nc(-c3cn[nH]c3)nc3cnccc23)CCC1 CHEMBL4443123 IC50 8.0 nM
CC(C)OCC(C)(C)Nc1cc(-c2ccncc2)nc2cnccc12 CHEMBL4475201 IC50 8.0 nM
CC[C@H](C)Nc1cc(-c2ccncc2)nc2cnccc12 CHEMBL4538809 IC50 8.0 nM
CN(C)CCC(C)(C)Nc1cc(-c2ccncc2)nc2cnccc12 CHEMBL4544973 IC50 8.0 nM
OCC(CC(F)(F)F)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4440480 IC50 9.0 nM
CCCCCNc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4450846 IC50 9.0 nM
CC(C)(O)CC(C)(C)Nc1nc(-c2c[nH]nc2C(F)(F)F)nc2cnccc12 CHEMBL4534660 IC50 9.0 nM
Cc1n[nH]cc1-c1nc(NC2(CO)CCC2)c2ccncc2n1 CHEMBL4582642 IC50 9.0 nM
Cn1nccc1-c1nc(NC2(C)CCC2)c2ccncc2n1 CHEMBL4534258 IC50 9.0 nM
CCN(CC)c1cc(-c2ccncc2)nc2cnccc12 CHEMBL4450968 IC50 9.0 nM
CC(CN)CNc1cc(-c2ccncc2)nc2cnccc12 CHEMBL4448408 IC50 9.6 nM
CC(CO)(CO)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4580434 IC50 10.0 nM
CCN(c1nc(-c2ccncc2F)nc2cnccc12)C(C)C CHEMBL4522938 IC50 10.0 nM
Cc1n[nH]c(C)c1-c1nc(NC(C)(C)C(F)(F)F)c2ccncc2n1 CHEMBL4453243 IC50 10.0 nM
CC(C)(CO)Nc1cc(-c2ccncc2F)nc2cnccc12 CHEMBL4455803 IC50 10.0 nM
CC(C)(N)CNc1cc(-c2ccncc2)nc2cnccc12 CHEMBL4440342 IC50 10.0 nM
CC1CNCCN1c1cc(-c2ccncc2)nc2cnccc12 CHEMBL4463799 IC50 10.2 nM
CC(C)(C)Nc1nc(-c2nonc2N)nc2cnccc12 CHEMBL4448628 IC50 10.4 nM
CN(C)CCC(C)(C)Nc1nc(-c2ccnc(F)c2)nc2cnccc12 CHEMBL4461790 IC50 10.5 nM
CCC(CO)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4461047 IC50 11.0 nM
CC(C)(Cc1c[nH]c2ccccc12)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4446641 IC50 11.0 nM
CC(C)(Cc1ccc(F)cc1)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4569437 IC50 11.0 nM
CC(C)(Nc1nc(-c2ccncc2)nc2cnccc12)c1ccccc1 CHEMBL4544743 IC50 11.0 nM
CCN(CC)c1cc(-c2ccncc2F)nc2cnccc12 CHEMBL4475654 IC50 11.0 nM
COC1CC(Nc2nc(-c3ccncc3)nc3cnccc23)C1 CHEMBL4446345 IC50 12.0 nM
CC(C)(Nc1nc(-c2c[nH]nc2C(F)(F)F)nc2cnccc12)C(F)(F)F CHEMBL4472559 IC50 12.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 12.8 nM
Fc1ccccc1Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4454934 IC50 13.0 nM
CC(C)(O)COCC(C)(C)Nc1cc(-c2ccncc2)nc2cnccc12 CHEMBL4521564 IC50 13.0 nM
CC(C)(C)Nc1cc(-c2ccnc(N)c2)nc2cnccc12 CHEMBL4467968 IC50 13.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 14.0 nM
CC(C)(O)COCC(C)(C)Nc1nc(-c2c[nH]nc2C(F)(F)F)nc2cnccc12 CHEMBL4452451 IC50 14.0 nM
CC(C)(O)CC(C)(C)Nc1nc(-c2cn[nH]c2)nc2cnccc12 CHEMBL4588897 IC50 14.0 nM
CC(C)N(C)c1nc(-c2ccncc2F)nc2cnccc12 CHEMBL4568040 IC50 15.0 nM
CC1(Nc2nc(-c3ccncn3)nc3cnccc23)CC1 CHEMBL4552944 IC50 16.0 nM
Cn1nccc1-c1nc(NC2(CO)CCC2)c2ccncc2n1 CHEMBL4437926 IC50 16.0 nM
CC1CCCCN1c1cc(-c2ccncc2)nc2cnccc12 CHEMBL4448179 IC50 16.0 nM
CC(O)C(C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4550313 IC50 17.0 nM
CC(C)(Nc1nc(-c2ccncc2)nc2cnccc12)c1ccc(F)cc1 CHEMBL4581198 IC50 17.0 nM
Cn1nccc1-c1nc(NC2(C)CC2)c2ccncc2n1 CHEMBL4445991 IC50 17.0 nM
FC(F)(F)C1(Nc2nc(-c3cn[nH]c3)nc3cnccc23)CC1 CHEMBL4448569 IC50 17.0 nM
CN(C)CCC(C)(C)Nc1cc(-c2ccncc2F)nc2cnccc12 CHEMBL4453187 IC50 17.0 nM
CCN(c1nc(-c2ccncc2C)nc2cnccc12)C(C)C CHEMBL4472409 IC50 18.0 nM
CCCNc1cc(-c2ccncc2)nc2cnccc12 CHEMBL4437496 IC50 18.0 nM
CC(C)(CCNC(=O)OC(C)(C)C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4566717 IC50 18.9 nM
CC1(C)CC(O)CCN1c1cc(-c2ccncc2Cl)nc2cnccc12 CHEMBL4561966 IC50 20.0 nM
CC(Nc1nc(-c2ccncc2)nc2cnccc12)(C(=O)O)C(F)(F)F CHEMBL4452896 IC50 21.0 nM
COCC(C)(C)Nc1nc(-c2ccncc2Cl)nc2cnccc12 CHEMBL4538846 IC50 22.0 nM
C[C@@H](N(C)c1nc(-c2ccncc2F)nc2cnccc12)C(F)(F)F CHEMBL4566878 IC50 22.0 nM
CC[C@@H](C)Nc1cc(-c2ccncc2)nc2cnccc12 CHEMBL4461494 IC50 22.0 nM
CC(C)(O)CC(C)(C)Nc1nc(-c2ccncc2Cl)nc2cnccc12 CHEMBL4475979 IC50 23.0 nM
CC(C)(CN)Nc1nc(-c2cn[nH]c2)nc2cnccc12 CHEMBL4476350 IC50 23.0 nM
COCC(C)(C)Nc1cc(-c2ccncc2)nc2cnccc12 CHEMBL4471933 IC50 23.0 nM
Cc1n[nH]c(C)c1-c1nc(NC(C)(C)CC(C)(C)O)c2ccncc2n1 CHEMBL4437922 IC50 24.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd apparent 25.0 nM
OCCNc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4581418 IC50 25.0 nM
CCCNc1nc(-c2c[nH]c3ncncc23)nc2cnccc12 CHEMBL4516822 IC50 25.0 nM
CNc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4464254 IC50 26.0 nM
NC[C@@](O)(c1ccc(Cl)cc1)c1ccc(-c2cn[nH]c2)cc1 CHEMBL3544960 Kd apparent 27.0 nM
CC1CCCCN1CC(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4545883 IC50 27.0 nM
Cc1[nH]ncc1-c1nc(N[C@H](C)c2ccccc2)c2ccncc2n1 CHEMBL4483329 IC50 28.0 nM
CCOC(=O)C(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4565212 IC50 29.2 nM
CC(C)(COCC(=O)O)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4547251 IC50 30.0 nM
OC1(CNc2nc(-c3ccncc3)nc3cnccc23)CCCC1 CHEMBL4579078 IC50 30.0 nM
CC(C)(CN1CCOCC1)Nc1cc(-c2ccncc2F)nc2cnccc12 CHEMBL4437210 IC50 30.0 nM
O[C@@H]1CCC[C@@H]1Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4449045 IC50 31.0 nM
CC(C)(O)CC(C)(C)Nc1nc(-c2ccncc2C#N)nc2cnccc12 CHEMBL4450745 IC50 33.0 nM
OCCC(Nc1nc(-c2ccncc2)nc2cnccc12)C(F)(F)F CHEMBL4582673 IC50 35.0 nM
CC(C)(CS(C)(=O)=O)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4586256 IC50 36.0 nM
C[C@](Nc1nc(-c2ccncc2)nc2cnccc12)(C(=O)O)C(F)(F)F CHEMBL4551662 IC50 36.0 nM
CN(C)c1nc(-c2ccncc2)nc2cnccc12 CHEMBL4516885 IC50 37.0 nM
CC(C)(CNCC(=O)O)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4522448 IC50 39.0 nM
CN[C@@H]1CCCC[C@H]1N(C)c1nc(-c2ccncc2)nc2cnccc12 CHEMBL4562357 IC50 40.0 nM
C[C@@](Nc1nc(-c2ccncc2)nc2cnccc12)(C(=O)O)C(F)(F)F CHEMBL4444552 IC50 41.0 nM
CC(C)(CNC(=O)OC(C)(C)C)CNc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4565547 IC50 42.5 nM
c1cc(-c2cc(N3CCNCC3)c3ccncc3n2)ccn1 CHEMBL4461247 IC50 43.3 nM
Cc1ccccc1Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4451092 IC50 44.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 45.0 nM
COC(=O)C(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4572425 IC50 47.0 nM
CCCNc1nc(-c2ccncc2Cl)nc2cnccc12 CHEMBL4525661 IC50 49.0 nM
CCCNc1nc(-c2c[nH]nc2C2CC2)nc2cnccc12 CHEMBL4446508 IC50 51.0 nM
Clc1cnccc1-c1nc(NC2CCCC2)c2ccncc2n1 CHEMBL4474308 IC50 53.0 nM
CN(c1nc(-c2cn[nH]c2)nc2cnccc12)C1(C)CC1 CHEMBL4447802 IC50 54.0 nM
CC(C)(O)COCC(C)(C)Nc1nc(-c2ccncc2Cl)nc2cnccc12 CHEMBL4542502 IC50 55.0 nM
CC(C)(Nc1nc(-c2ccncc2)nc2cnccc12)C(N)=O CHEMBL4457273 IC50 57.2 nM
FC(F)(F)[C@H]1CN(c2nc(-c3ccncc3)nc3cnccc23)CCN1 CHEMBL4549171 IC50 58.1 nM
CC1(C)CN(c2cc(-c3ccncc3)nc3cnccc23)CCN1 CHEMBL4577411 IC50 59.0 nM
CN(C)C(C)(C)CNc1cc(-c2ccncc2)nc2cnccc12 CHEMBL4522691 IC50 59.5 nM
CCn1nccc1-c1nc(NC2(C)CC2)c2ccncc2n1 CHEMBL4578145 IC50 61.0 nM
CC(C)N(C)c1cc(-c2ccncc2)nc2cnccc12 CHEMBL4574675 IC50 61.0 nM
Cn1cncc1C1=CN(c2ncnc3[nH]cnc23)CCS1 CHEMBL5433617 IC50 64.0 nM
CC(C)N(C)c1cc(-c2ccncc2F)nc2cnccc12 CHEMBL4576797 IC50 65.0 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 Kd apparent 66.0 nM
COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL281948 Kd apparent 67.0 nM
CN(C)CCC(C)(C)Nc1nc(-c2ccncn2)nc2cnccc12 CHEMBL4556611 IC50 68.7 nM
CC1(Nc2nc(-c3c(F)cncc3F)nc3cnccc23)CC1 CHEMBL4471243 IC50 69.0 nM
O[C@H]1CCC[C@@H]1Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4461657 IC50 71.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OC[C@H]3CCCNC3)c21 CHEMBL494089 Kd apparent 74.0 nM
Cc1cnccc1-c1nc(N(C)C(C)C)c2ccncc2n1 CHEMBL4532329 IC50 77.0 nM
COC(=O)[C@H]1C[C@@H](Nc2nc(-c3ccncc3)nc3cnccc23)C1 CHEMBL4449726 IC50 78.0 nM
Cn1nccc1-c1nc(NC2(C(F)(F)F)CC2)c2ccncc2n1 CHEMBL4535305 IC50 83.0 nM
CC(C)(C)Nc1nc(-c2ccncc2)nc2cncc(NCCOCCO)c12 CHEMBL4454374 IC50 85.0 nM
Fc1cnccc1-c1cc(N2CCCCC2)c2ccncc2n1 CHEMBL4557740 IC50 90.0 nM
CC(C)(Nc1nc(-c2ccncc2)nc2cnccc12)C(=O)O CHEMBL4451071 IC50 95.0 nM
CC1(C)CN(c2cc(-c3ccncc3)nc3cnccc23)CCO1 CHEMBL4464722 IC50 97.1 nM
CN(c1nc(-c2cnn(C)c2)nc2cnccc12)C1(C)CC1 CHEMBL4444537 IC50 98.0 nM
Cc1n[nH]cc1-c1nc(NC(C)c2ccncc2)c2ccncc2n1 CHEMBL4552005 IC50 99.0 nM
OCCOCCNc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4442477 IC50 118.0 nM
C[C@](O)(CNc1cc(-c2ccncc2)nc2cnccc12)C(F)(F)F CHEMBL4470844 IC50 125.1 nM
Cc1ccc(Nc2nc(-c3ccncc3)nc3cnccc23)cc1 CHEMBL4436050 IC50 126.0 nM
COC(=O)CC1(Nc2nc(-c3ccncc3)nc3cnccc23)CC1 CHEMBL4553844 IC50 126.0 nM
C[C@@H](Nc1nc(-c2cn[nH]c2)nc2cnccc12)c1ccccc1 CHEMBL4472484 IC50 143.0 nM
COc1ccc(Nc2nc(-c3ccncc3)nc3cnccc23)cc1 CHEMBL4463357 IC50 148.0 nM
Cc1nc(Nc2n[nH]c3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)c2sccc2n1 CHEMBL3128043 Kd apparent 157.0 nM
CCCNc1nc(-c2ccncc2C)nc2cnccc12 CHEMBL4440637 IC50 159.0 nM
CC(C)(CNc1nc(-c2ccncc2)nc2cnccc12)NC(=O)OC(C)(C)C CHEMBL4444841 IC50 163.9 nM
CC1(Nc2nc(-c3ccnc(F)c3F)nc3cnccc23)CC1 CHEMBL4527745 IC50 168.0 nM
CC1(Nc2nc(-c3cncs3)nc3cnccc23)CC1 CHEMBL4561290 IC50 171.0 nM
CC(C)(CCS(C)(=O)=O)Nc1nc(-c2ccncc2Cl)nc2cnccc12 CHEMBL4458991 IC50 187.0 nM
OCC1(Nc2nc(-c3cn[nH]c3)nc3cnccc23)CCC1 CHEMBL4472859 IC50 189.0 nM
CC(C)(C)Nc1cc(-c2ccncc2Cl)nc2cnccc12 CHEMBL4458288 IC50 190.0 nM
C[C@]1(O)C[C@@H](c2nc(-c3ccc4ccc(-c5ccccc5)nc4c3)c3c(N)nccn32)C1 CHEMBL1091644 Kd apparent 195.0 nM
CC1(Nc2nc(-c3ccnnc3)nc3cnccc23)CC1 CHEMBL4446094 IC50 197.0 nM
OCC(CO)(CO)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4518541 IC50 199.0 nM
OCC1(Nc2nc(-c3cn[nH]c3)nc3cnccc23)CC1 CHEMBL4456319 IC50 201.0 nM
c1cc(-c2cc(NC3COC3)c3ccncc3n2)ccn1 CHEMBL4483670 IC50 208.9 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1 CHEMBL3301622 Kd apparent 221.0 nM
CC(C)(CC(=O)O)NC(=O)CC(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4456449 IC50 233.0 nM
Cc1c(-c2nc(NC(C)(C)C)c3ccncc3n2)c2cccnc2n1S(=O)(=O)c1ccccc1 CHEMBL4455852 IC50 235.0 nM
FC(F)(F)C(Cc1ccccc1)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4589539 IC50 240.0 nM
CN(C)C1(CNc2nc(-c3ccncc3)nc3cnccc23)CCOCC1 CHEMBL4566871 IC50 244.0 nM
CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL3991929 Kd apparent 261.0 nM
c1ccc(Nc2nc(-c3ccncc3)nc3cnccc23)cc1 CHEMBL4533517 IC50 304.0 nM
CC1(Nc2nc(-c3c[nH]nn3)nc3cnccc23)CC1 CHEMBL4467512 IC50 322.0 nM
CC1(Nc2nc(-c3cnco3)nc3cnccc23)CC1 CHEMBL4547989 IC50 324.0 nM
CC(C)(CC(=O)O)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4577102 IC50 328.0 nM
Cn1cc(C2=Nc3cc(NC(=O)C(N)C4CCCCC4)cc4c3C2=CNNC4=O)cn1 CHEMBL3545137 Kd apparent 363.0 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 Kd apparent 406.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 420.0 nM
CN1CCN(c2cc(-c3ccncc3)nc3cnccc23)CC1 CHEMBL4438995 IC50 457.0 nM
CC(C)(CCO)Nc1cc(-c2ccncc2)nc2cnccc12 CHEMBL4564095 IC50 459.0 nM
CCOC(=O)C1(Nc2nc(-c3ccncc3)nc3cnccc23)CCC1 CHEMBL4443872 IC50 460.0 nM
CC(C)(C)Nc1cc(-c2ccnnc2)nc2cnccc12 CHEMBL4435927 IC50 463.0 nM
CN(C)C(=O)C(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4539019 IC50 466.7 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 470.0 nM
CCN(CC)c1cc(-c2ccncc2Cl)nc2cnccc12 CHEMBL4453008 IC50 560.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 630.0 nM
CCNC(=O)C#Cc1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN(C)C)cc1)c1ccccc1 CHEMBL3699142 Kd apparent 635.0 nM
FC(F)(F)[C@H]1CN(c2cc(-c3ccncc3)nc3cnccc23)CCN1 CHEMBL4551335 IC50 662.9 nM
CNC(=O)c1nn(C)c2c1C(C)(C)Cc1cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc1-2 CHEMBL564829 Kd apparent 681.0 nM
CS(=O)(=O)CCNc1nc(-c2ccncc2)nc2cnccc12 CHEMBL4472604 IC50 708.0 nM
CC(C)(Nc1nc(-c2ccncc2)nc2cnccc12)C12CC3CC(CC(C3)C1)C2 CHEMBL4464290 IC50 711.0 nM
CC(Nc1nc(-c2cn[nH]c2)nc2cnccc12)c1ccncc1 CHEMBL4462156 IC50 797.0 nM
Cc1cccc(Nc2nc(-c3ccncc3)nc3cnccc23)c1 CHEMBL4522043 IC50 809.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 850.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 Kd apparent 955.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM