O=C1Nc2[nH]nc(C3CCN(c4cnc(C(F)(F)F)cn4)CC3)c2C(O)(C(F)(F)F)C1O CHEMBL4571766 EC50 4.0 nM
O=C1Nc2[nH]nc(C3CCN(c4cnc(C(F)(F)F)cn4)CC3)c2C(O)(C(F)(F)F)C1O CHEMBL4444702 EC50 4.0 nM
N#Cc1cc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)ccc1OC(F)(F)F CHEMBL4543681 EC50 7.0 nM
O=C(OCc1ccccc1)c1cc(N2CCC(c3n[nH]c4c3[C@@H](C(F)(F)F)[C@@H](O)C(=O)N4)CC2)ncc1C(F)(F)F CHEMBL4444091 EC50 7.0 nM
O=C1Nc2[nH]nc(C3CCN(c4ccc(C(F)(F)F)cn4)CC3)c2C(O)(C(F)(F)F)C1O CHEMBL4567833 EC50 7.0 nM
O=C1Nc2[nH]nc(C3CCN(c4ccc(C(F)(F)F)nc4)CC3)c2[C@@H](C(F)(F)F)[C@H]1O CHEMBL4449961 EC50 8.0 nM
O=C1Nc2[nH]nc(C3CCN(c4cnc(C(F)(F)F)cn4)CC3)c2[C@@H](C(F)(F)F)[C@H]1O CHEMBL4438875 EC50 9.0 nM
O=C1Nc2[nH]nc(C3CCN(c4ccc(-c5ccccc5)nn4)CC3)c2[C@@H](C(F)(F)F)[C@H]1O CHEMBL4565710 EC50 11.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4cnc(C(F)(F)F)cn4)CC3)n[nH]c2N1 CHEMBL4565889 EC50 12.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4cnc(C(F)(F)F)nc4)CC3)n[nH]c2N1 CHEMBL4475628 EC50 13.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4cc(C(=O)OCc5ccccc5)c(C(F)(F)F)cn4)CC3)n[nH]c2N1 CHEMBL4449770 EC50 13.0 nM
O=C1Nc2[nH]nc(C3CCN(c4ccc(C(F)(F)F)cn4)CC3)c2[C@@H](C(F)(F)F)[C@H]1O CHEMBL4444770 EC50 13.0 nM
N#Cc1nc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)ccc1C(F)(F)F CHEMBL4462753 EC50 15.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ccc(C(F)(F)F)cn4)CC3)n[nH]c2N1 CHEMBL4438084 EC50 18.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ccc(OC(F)(F)F)cn4)CC3)n[nH]c2N1 CHEMBL4435610 EC50 18.0 nM
O=C1Nc2[nH]nc(C3CCN(c4cnc(C(F)(F)F)nc4)CC3)c2[C@@H](C(F)(F)F)[C@H]1O CHEMBL4592989 EC50 18.0 nM
O=C1Nc2[nH]nc(C3CCN(c4cnc(C(F)(F)F)nc4)CC3)c2[C@@H](C(F)(F)F)[C@H]1O CHEMBL4463860 EC50 18.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ccc(OC(F)(F)F)cc4)CC3)n[nH]c2N1 CHEMBL4453452 EC50 20.0 nM
N#Cc1cc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)ccc1OC(F)F CHEMBL4455643 EC50 21.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4cc(I)c(C(F)(F)F)cn4)CC3)n[nH]c2N1 CHEMBL4445217 EC50 21.0 nM
CC(C)(C)c1ncc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)cn1 CHEMBL4443799 EC50 23.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ccc(C(F)(F)F)c(Cl)n4)CC3)n[nH]c2N1 CHEMBL4445235 EC50 23.0 nM
O=C1Nc2[nH]nc(C3CCN(c4cncc(C(F)(F)F)c4)CC3)c2[C@@H](C(F)(F)F)[C@H]1O CHEMBL4456783 EC50 24.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ccc(C(F)(F)F)nc4)CC3)n[nH]c2N1 CHEMBL4442211 EC50 26.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ccc(-c5ccccc5)nn4)CC3)n[nH]c2N1 CHEMBL4541184 EC50 27.0 nM
CC(C)c1nc(N2CCC(c3n[nH]c4c3[C@H](C(F)(F)F)[C@H](O)C(=O)N4)CC2)cc(C(F)(F)F)n1 CHEMBL4435684 EC50 27.0 nM
O=C1Nc2[nH]nc(C3CCN(c4cnc(C(F)(F)F)cn4)CC3)c2[C@H](C(F)(F)F)[C@@H]1O CHEMBL4514555 EC50 29.0 nM
N#Cc1ncc(N2CCC(c3n[nH]c4c3[C@@H](C(F)(F)F)[C@@H](O)C(=O)N4)CC2)cc1F CHEMBL4536836 EC50 30.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4cnc(OC(F)F)c(OC(F)F)c4)CC3)n[nH]c2N1 CHEMBL4483570 EC50 31.0 nM
O=C1Nc2[nH]nc(C3CCN(c4cc(C(F)(F)F)ccn4)CC3)c2[C@H](C(F)(F)F)[C@@H]1O CHEMBL4563848 EC50 31.0 nM
COC(=O)c1cc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)ncc1C(F)(F)F CHEMBL4575561 EC50 32.0 nM
O=C1Nc2[nH]nc(C3CCN(c4ccc(Cl)cn4)CC3)c2[C@@H](C(F)(F)F)[C@H]1O CHEMBL4461575 EC50 32.0 nM
N#Cc1cncc(N2CCC(c3n[nH]c4c3[C@@H](C(F)(F)F)[C@@H](O)C(=O)N4)CC2)c1 CHEMBL4450717 EC50 34.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ccc(C(F)(F)F)c(F)n4)CC3)n[nH]c2N1 CHEMBL4515289 EC50 35.0 nM
O=C1Nc2[nH]nc(C3CCN(c4ccc(C(F)(F)F)nn4)CC3)c2[C@@H](C(F)(F)F)[C@H]1O CHEMBL4577479 EC50 35.0 nM
O=C1Nc2[nH]nc(C3CCN(c4cnc(C(F)(F)F)nc4)CC3)c2[C@H](C(F)(F)F)[C@@H]1O CHEMBL4466792 EC50 35.0 nM
CC(C)Oc1ccc(N2CCC(c3n[nH]c4c3[C@@H](C(F)(F)F)[C@@H](O)C(=O)N4)CC2)nn1 CHEMBL4567145 EC50 35.0 nM
N#Cc1cnc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)cc1C(F)(F)F CHEMBL4461964 EC50 37.0 nM
N#Cc1cnc(N2CCC(c3n[nH]c4c3[C@H](C(F)(F)F)[C@H](O)C(=O)N4)CC2)cc1C(F)(F)F CHEMBL4440456 EC50 37.0 nM
Cc1cc(N2CCC(c3n[nH]c4c3[C@@H](C(F)(F)F)[C@@H](O)C(=O)N4)CC2)cnc1C#N CHEMBL4448781 EC50 37.0 nM
O=C1Nc2[nH]nc(C3CCN(c4ccc(C(F)(F)F)cn4)CC3)c2[C@H](C(F)(F)F)[C@@H]1O CHEMBL4526869 EC50 40.0 nM
CC(C)Oc1ccc(N2CCC(c3n[nH]c4c3[C@@H](C(F)(F)F)[C@@H](O)C(=O)N4)CC2)nc1 CHEMBL4436647 EC50 41.0 nM
N#Cc1ncc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)cc1F CHEMBL4440507 EC50 43.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ccc(OC(F)F)cc4)CC3)n[nH]c2N1 CHEMBL4435430 EC50 45.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4nc(C(F)(F)F)c(-c5nc(C(F)(F)F)cs5)s4)CC3)n[nH]c2N1 CHEMBL4453731 EC50 46.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4cccc(C(F)(F)F)n4)CC3)n[nH]c2N1 CHEMBL4567290 EC50 48.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4cncc(C(F)(F)F)c4)CC3)n[nH]c2N1 CHEMBL4454322 EC50 50.0 nM
N#Cc1cnc(N2CCC(c3n[nH]c4c3[C@@H](C(F)(F)F)[C@@H](O)C(=O)N4)CC2)cc1C(F)(F)F CHEMBL4445495 EC50 51.0 nM
COc1cccc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)n1 CHEMBL4578456 EC50 54.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4cc(C(F)(F)F)ccn4)CC3)n[nH]c2N1 CHEMBL4576610 EC50 56.0 nM
N#Cc1ccnc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)c1 CHEMBL4514862 EC50 56.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ccc(C(F)(F)F)nn4)CC3)n[nH]c2N1 CHEMBL4456188 EC50 56.0 nM
CC(C)c1ccc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)nc1 CHEMBL4518759 EC50 56.0 nM
O=C1Nc2[nH]nc(C3CCN(c4cc(C(=O)N5CCCCC5)c(C(F)(F)F)cn4)CC3)c2[C@@H](C(F)(F)F)[C@H]1O CHEMBL4539903 EC50 57.0 nM
COC(=O)c1nc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)ccc1C(F)(F)F CHEMBL4560530 EC50 58.0 nM
O=C1Nc2[nH]nc(C3CCN(c4cccc(C(F)(F)F)n4)CC3)c2[C@H](C(F)(F)F)[C@@H]1O CHEMBL4556066 EC50 62.0 nM
O=C1Nc2[nH]nc(C3CCN(c4cc(C(F)(F)F)ncn4)CC3)c2[C@@H](C(F)(F)F)[C@H]1O CHEMBL4558558 EC50 63.0 nM
CC(C)Oc1ccc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)nn1 CHEMBL4536600 EC50 64.0 nM
O=C1Nc2[nH]nc(C3CCN(c4nnc(C(F)(F)F)s4)CC3)c2[C@@H](C(F)(F)F)[C@H]1O CHEMBL4537945 EC50 65.0 nM
CC(C)Oc1ccc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)nc1 CHEMBL4569673 EC50 67.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4cnc(C5CC5)nc4)CC3)n[nH]c2N1 CHEMBL4447960 EC50 68.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ccc(OC(F)F)nc4)CC3)n[nH]c2N1 CHEMBL4452113 EC50 70.0 nM
O=C1Nc2[nH]nc(C3CCN(c4cnc(C5CC5)nc4)CC3)c2[C@@H](C(F)(F)F)[C@H]1O CHEMBL4514499 EC50 70.0 nM
N#Cc1cncc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)c1 CHEMBL4447105 EC50 71.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ccc(C5CC5)cn4)CC3)n[nH]c2N1 CHEMBL4516853 EC50 75.0 nM
CCOC(=O)c1oc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)nc1C(F)(F)F CHEMBL4458552 EC50 77.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4nc(C(F)(F)F)cs4)CC3)n[nH]c2N1 CHEMBL4557346 EC50 80.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ccc(OC(F)F)cn4)CC3)n[nH]c2N1 CHEMBL4581249 EC50 81.0 nM
CCc1ccc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)nc1 CHEMBL4455680 EC50 83.0 nM
CN(C)c1nc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)cc(C(F)(F)F)n1 CHEMBL4471254 EC50 84.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ccc(Cl)cn4)CC3)n[nH]c2N1 CHEMBL4567835 EC50 86.0 nM
CC(C)c1nc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)cc(C(F)(F)F)n1 CHEMBL4515461 EC50 88.0 nM
CC(C)Oc1ccc(N2CCC(c3n[nH]c4c3[C@@H](C(F)(F)F)[C@@H](O)C(=O)N4)CC2)cn1 CHEMBL4446975 EC50 92.0 nM
O=C1Nc2[nH]nc(C3CCN(c4ccc(OC(F)F)cn4)CC3)c2[C@@H](C(F)(F)F)[C@H]1O CHEMBL4550163 EC50 94.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ccc5ccccc5n4)CC3)n[nH]c2N1 CHEMBL4472635 EC50 96.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4nnc(C(F)(F)F)s4)CC3)n[nH]c2N1 CHEMBL4448173 EC50 96.0 nM
CC(C)Oc1ccc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)cn1 CHEMBL4450856 EC50 100.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ccc(OC5CCC5)nc4)CC3)n[nH]c2N1 CHEMBL4437681 EC50 100.0 nM
O=C1Nc2[nH]nc(C3CCN(c4ccnc(C(F)(F)F)n4)CC3)c2[C@@H](C(F)(F)F)[C@H]1O CHEMBL4556164 EC50 100.0 nM
CC(C)Oc1ccc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)nn1 CHEMBL4518653 EC50 101.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ncc(-c5ccccc5)s4)CC3)n[nH]c2N1 CHEMBL4513336 EC50 110.0 nM
O=C1Nc2[nH]nc(C3CCN(c4ccc(C(F)(F)F)nn4)CC3)c2[C@H](C(F)(F)F)[C@@H]1O CHEMBL4453016 EC50 110.0 nM
N#Cc1cccc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)c1 CHEMBL4435155 EC50 120.0 nM
Cc1cc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)ncc1C#N CHEMBL4562984 EC50 140.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4cc(C(F)(F)F)ncn4)CC3)n[nH]c2N1 CHEMBL4521912 EC50 140.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ccc(Br)cn4)CC3)n[nH]c2N1 CHEMBL4538294 EC50 140.0 nM
CN(C)c1cc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)nc(C(F)(F)F)n1 CHEMBL4442969 EC50 140.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4nc5ccccc5o4)CC3)n[nH]c2N1 CHEMBL4546005 EC50 150.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ccc(Cl)nn4)CC3)n[nH]c2N1 CHEMBL4536350 EC50 150.0 nM
CC(C)Oc1ccc(N2CCC(c3n[nH]c4c3[C@H](C(F)(F)F)[C@H](O)C(=O)N4)CC2)nc1 CHEMBL4528227 EC50 160.0 nM
N#Cc1cnc(N2CCC(c3n[nH]c4c3[C@@H](C(F)(F)F)[C@@H](O)C(=O)N4)CC2)cn1 CHEMBL4446874 EC50 160.0 nM
N#Cc1cc(C(F)(F)F)cnc1N1CCC(c2n[nH]c3c2C(O)(C(F)(F)F)CC(=O)N3)CC1 CHEMBL4533682 EC50 170.0 nM
N#Cc1cccc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)n1 CHEMBL4464024 EC50 180.0 nM
CN(C)C(=O)c1cc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)ccc1C(F)(F)F CHEMBL4442251 EC50 190.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4nc5ccccc5s4)CC3)n[nH]c2N1 CHEMBL4446184 EC50 200.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ncc(C(F)(F)F)cc4Cl)CC3)n[nH]c2N1 CHEMBL4473916 EC50 210.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4cc(C(F)(F)F)nc(C5CC5)n4)CC3)n[nH]c2N1 CHEMBL4475020 EC50 210.0 nM
CC(C)c1cc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)nc(C(C)C)n1 CHEMBL4465810 EC50 220.0 nM
N#Cc1cnc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)cn1 CHEMBL4438802 EC50 220.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ncc(C(F)(F)F)cc4F)CC3)n[nH]c2N1 CHEMBL4446478 EC50 220.0 nM
Cc1ccc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)nc1 CHEMBL4456984 EC50 250.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ccc(F)cn4)CC3)n[nH]c2N1 CHEMBL4580022 EC50 250.0 nM
Cc1cncc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)n1 CHEMBL4462725 EC50 260.0 nM
CCOc1ccc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)cc1 CHEMBL4461930 EC50 260.0 nM
N#Cc1ccc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)nc1Cl CHEMBL4554081 EC50 270.0 nM
CN(C)C(=O)c1cc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)ncc1C(F)(F)F CHEMBL4439990 EC50 270.0 nM
Cc1ccnc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)c1 CHEMBL4524823 EC50 290.0 nM
Cc1nc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)ccc1C#N CHEMBL4445962 EC50 290.0 nM
O=C1Nc2[nH]nc(C3CCN(c4nc(C(F)(F)F)cs4)CC3)c2[C@H](C(F)(F)F)[C@@H]1O CHEMBL4543649 EC50 290.0 nM
COc1ccc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)nn1 CHEMBL4554654 EC50 300.0 nM
COc1ccc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)cn1 CHEMBL4446723 EC50 300.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ccc(F)cc4)CC3)n[nH]c2N1 CHEMBL4558170 EC50 300.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ccnc(C(F)(F)F)n4)CC3)n[nH]c2N1 CHEMBL4545829 EC50 300.0 nM
Cc1nc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)cc(C(F)(F)F)n1 CHEMBL4548741 EC50 300.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4nc(-c5ccccc5)cs4)CC3)n[nH]c2N1 CHEMBL4435796 EC50 310.0 nM
N#Cc1ccc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)nc1 CHEMBL4545186 EC50 330.0 nM
COc1ccnc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)c1 CHEMBL4458680 EC50 330.0 nM
CN(C)c1ncc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)cn1 CHEMBL4468730 EC50 330.0 nM
O=C1Nc2[nH]nc(C3CCN(c4cnc(C(F)(F)F)cn4)CC3)c2[C@@H](C(F)(F)F)[C@@H]1O CHEMBL4467443 EC50 340.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ncc(C(F)(F)F)cn4)CC3)n[nH]c2N1 CHEMBL4567002 EC50 360.0 nM
N#Cc1ccc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)cc1 CHEMBL4472166 EC50 380.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4nccc(C(F)(F)F)n4)CC3)n[nH]c2N1 CHEMBL4536394 EC50 380.0 nM
O=C1Nc2[nH]nc(C3CCN(c4ncc(C(F)(F)F)cc4Cl)CC3)c2[C@H](C(F)(F)F)[C@@H]1O CHEMBL4463220 EC50 380.0 nM
COc1ccc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)nc1 CHEMBL4465529 EC50 420.0 nM
CN(C)C(=O)c1nc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)ccc1C(F)(F)F CHEMBL4462410 EC50 420.0 nM
N#Cc1cnc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)s1 CHEMBL4449909 EC50 470.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4nc(Cl)ccc4C(F)(F)F)CC3)n[nH]c2N1 CHEMBL4536147 EC50 510.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4ccccn4)CC3)n[nH]c2N1 CHEMBL4441525 EC50 520.0 nM
O=C1CC(O)(C(F)(F)F)c2c(C3CCN(c4nc(C5CC5)no4)CC3)n[nH]c2N1 CHEMBL4517123 EC50 520.0 nM
Cc1cccc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)n1 CHEMBL4463996 EC50 630.0 nM
CC(C)c1nc(N2CCC(c3n[nH]c4c3[C@H](C(F)(F)F)[C@@H](O)C(=O)N4)CC2)cc(C(F)(F)F)n1 CHEMBL4452741 EC50 630.0 nM
N#Cc1ccc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)cn1 CHEMBL4571872 EC50 650.0 nM
CN(C)c1ccc(N2CCC(c3n[nH]c4c3C(O)(C(F)(F)F)CC(=O)N4)CC2)cn1 CHEMBL4438696 EC50 760.0 nM
O=C1Nc2[nH]nc(C3CCN(c4ccc(C(F)(F)F)cn4)CC3)c2[C@H](C(F)(F)F)[C@H]1O CHEMBL4455091 EC50 880.0 nM