CNc1ncc2cc(-c3cc(C(=O)Nc4cccc(C(F)(F)F)c4C)ccc3C)ccc2n1 CHEMBL215969 IC50 0.01 nM
COC(C)(C)CCn1nc(Nc2c(C)cccc2C)c2cnc(Nc3ccc(OCCN4CCCC4)cc3)nc21 CHEMBL458333 Ki 0.04 nM
C[C@H](Nc1nccc(-n2cnc3ccccc32)n1)[C@@H]1CN(C(=O)Nc2cccc3ccccc23)CCN1C CHEMBL566813 IC50 0.06 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2C)cc1-c1ccc2nc(NC3CC3)ncc2c1 CHEMBL212181 IC50 0.07 nM
CCN1CCN(C(=O)Nc2cccc3ccccc23)C[C@H]1[C@H](C)Nc1nccc(-n2cnc3ccccc32)n1 CHEMBL569496 IC50 0.07 nM
C[C@H](Nc1nccc(-n2cnc3cc(-c4ccnc(N)n4)ccc32)n1)[C@@H]1CN(C(=O)Nc2cccc3ccccc23)CCN1C CHEMBL566284 IC50 0.07 nM
C[C@H](Nc1nccc(-n2cnc3cc(-c4ccncc4)ccc32)n1)[C@@H]1CN(C(=O)Nc2cccc3ccccc23)CCN1C CHEMBL572197 IC50 0.12 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1 CHEMBL215943 IC50 0.2 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2nc(N)ncc2c1 CHEMBL385937 IC50 0.2 nM
Cc1nc(NCCO)cc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)n1 CHEMBL386118 IC50 0.2 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL5416410 Kd 0.2 nM
CC(C)CN1CCN(C(=O)Nc2cccc3ccccc23)C[C@H]1[C@H](C)Nc1nccc(-n2cnc3ccccc32)n1 CHEMBL568762 IC50 0.2 nM
C[C@H](Nc1nccc(-n2cnc3ccccc32)n1)[C@@H]1CN(C(=O)Nc2cccc3ccccc23)CCN1c1ccncc1 CHEMBL565263 IC50 0.2 nM
CCN(CC)CCOc1ccc(Nc2ncc3c(n2)N(C)C(=O)N(c2c(Cl)cccc2Cl)C3)cc1 CHEMBL1234002 Kd 0.2 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCCC(=O)N3CCN(c4ccc(N5CCC(=O)NC5=O)cc4)CC3)CC2)n1 CHEMBL5283559 DC50 0.23 nM
CC(Nc1nccc(-n2cnc3ccccc32)n1)C1CN(C(=O)Nc2cccc3ccccc23)CCN1C CHEMBL569052 IC50 0.25 nM
CNc1ncc2cc(-c3cc(C(=O)Nc4cccc(C(F)(F)F)c4)ccc3C)ccc2n1 CHEMBL212964 IC50 0.27 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1171837 IC50 0.28 nM
CNc1ncc2cc(-c3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)ccc2n1 CHEMBL212128 IC50 0.3 nM
CNc1ncc2cc(-c3cc(C(=O)Nc4cccc5c4CCC5)ccc3C)ccc2n1 CHEMBL427233 IC50 0.3 nM
Cc1cccc(C)c1NC(=O)c1cnc(Nc2cccnn2)s1 CHEMBL405630 IC50 0.3 nM
Cc1ccc(NC(=O)c2cc(F)cc(C(F)(F)F)c2)cc1C(=O)Nc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1 CHEMBL407063 IC50 0.3 nM
NCCOc1ccc2c(c1)Nc1c(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)nn1CC2 CHEMBL607366 IC50 0.3 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2C)cc1-c1ccc2nc(NCCCN3CCOCC3)ncc2c1 CHEMBL214530 IC50 0.4 nM
Nc1ncc2cc(-c3cc(C(=O)Nc4cccc(C(F)(F)F)c4)ccc3Cl)ccc2n1 CHEMBL212900 IC50 0.4 nM
CNc1ncc2cc(-c3cc(C(=O)Nc4cc(C(F)(F)F)ccc4NC(=O)NCCN4CCOCC4)ccc3C)ccc2n1 CHEMBL213831 IC50 0.4 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1ccc2nc(N)ncc2c1 CHEMBL429582 IC50 0.4 nM
C[C@H](Nc1nccc(-n2cnc3ccccc32)n1)[C@H]1CCCN(C(=O)Nc2cccc3ccccc23)C1 CHEMBL569272 IC50 0.4 nM
CCN1CCN(c2ccc3c(c2)ncn3-c2ccnc(N[C@@H](C)[C@@H]3CN(C(=O)Nc4cccc5ccccc45)CCN3C)n2)C1=O CHEMBL568759 IC50 0.4 nM
NCCOc1ccc2c(c1)CCn1nc(-c3ccc(Oc4ccccc4)cc3)c(C(N)=O)c1N2 CHEMBL591324 IC50 0.41 nM
CN(C)CCOc1ccc2c(c1)CCn1nc(-c3ccc(O)cc3)c(C(N)=O)c1N2 CHEMBL595398 IC50 0.44 nM
CCOC(=O)CN1CCN(C(=O)Nc2cccc3ccccc23)C[C@H]1[C@H](C)Nc1nccc(-n2cnc3ccccc32)n1 CHEMBL566507 IC50 0.45 nM
Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3cccc(NCCO)n3)sc2c1 CHEMBL312933 IC50 0.5 nM
CCN(CC)C/C=C/c1nc(O)c2c(ccc3nc(Nc4c(Cl)cccc4Cl)n(C)c32)c1C CHEMBL281957 IC50 0.5 nM
CNc1ncc2cc(-c3cc(C(=O)Nc4cccc(C(F)(F)F)c4)c(F)cc3C)ccc2n1 CHEMBL215745 IC50 0.5 nM
CCN(CC)CC(=O)Nc1ccc(C(F)(F)F)cc1NC(=O)c1ccc(C)c(-c2ccc3nc(NC)ncc3c2)c1 CHEMBL212953 IC50 0.5 nM
CNc1ncc2cc(-c3cc(C(=O)Nc4cc(C(F)(F)F)ccc4OC4CCN(C)CC4)ccc3C)ccc2n1 CHEMBL386661 IC50 0.5 nM
CNc1ncc2cc(-c3cc(C(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)ccc3C)ccc2n1 CHEMBL215019 IC50 0.5 nM
Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2cc(N3CCOCC3)ncn2)s1 CHEMBL189649 IC50 0.5 nM
Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2cccc(NCCCN3CCOCC3)n2)s1 CHEMBL273250 IC50 0.5 nM
Cc1ccnc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)c1 CHEMBL186568 IC50 0.5 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1C(=O)Nc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1 CHEMBL408070 IC50 0.5 nM
CN(C)CCCOc1ccc2c(c1)Nc1c(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)nn1CC2 CHEMBL592260 IC50 0.51 nM
Cc1cc(Nc2nc3ccc(C(=O)Nc4c(C)cccc4Cl)cc3s2)nc(NCC2CCCO2)n1 CHEMBL432189 Ki 0.54 nM
CN1CCN(CCOc2ccc3c(c2)Nc2c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn2CC3)CC1 CHEMBL592262 IC50 0.55 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn2c1Nc1ccc(OCCN3CCOCC3)cc1CC2 CHEMBL596079 IC50 0.56 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 Kd 0.59 nM
COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3cc(OC)c(OCCCN4CCN(C)CC4)c(OC)c3)n2)c(OC)c1 CHEMBL386760 IC50 0.6 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2C)cc1-c1ccc2nc(NC3CCN(C)CC3)ncc2c1 CHEMBL215691 IC50 0.6 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2C)cc1-c1ccc2nc(N)ncc2c1 CHEMBL215813 IC50 0.6 nM
Cc1cccc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)n1 CHEMBL365505 IC50 0.6 nM
COc1nc(Nc2ccc(N3CCN(C)CC3)cc2)ncc1C(=O)Nc1cc(C(=O)Nc2cccc(C(F)(F)F)c2F)ccc1C CHEMBL257858 IC50 0.6 nM
Cc1ccc(NC(=O)Nc2cccc(C(F)(F)F)c2)cc1C(=O)Nc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1 CHEMBL405666 IC50 0.6 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1C(=O)Nc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1 CHEMBL272888 IC50 0.6 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCC(CO)CC2)n1 CHEMBL216240 IC50 0.7 nM
Cc1nc(NCCCN2CCOCC2)cc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)n1 CHEMBL214617 IC50 0.7 nM
CN(C)CCOc1ccc2c(c1)CCn1nc(-c3ccc(Oc4ccccc4)cc3)c(C(N)=O)c1N2 CHEMBL591325 IC50 0.72 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn2c1Nc1ccc(OCCO)cc1CC2 CHEMBL601096 IC50 0.75 nM
CN(C)C/C=C/C(=O)N[C@H]1CC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 CHEMBL3893004 IC50 0.76 nM
CN(C)C/C=C/C(=O)NC1CCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 CHEMBL3980550 IC50 0.76 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn2c1Nc1cc(OCCN3CCOCC3)ccc1CC2 CHEMBL591793 IC50 0.77 nM
CC(C)(C)n1nc(-c2ccc(Cl)cc2)c2c(N)ncnc21 CHEMBL406845 pKi 0.7943 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2C)cc1C(=O)Nc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1 CHEMBL271140 IC50 0.8 nM
CN(C)CCOc1ccc2c(c1)CCn1nc(-c3ccc(Nc4ccccc4)cc3)c(C(N)=O)c1N2 CHEMBL595624 IC50 0.8 nM
C=CC(=O)N[C@H]1CC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 CHEMBL3912266 IC50 0.88 nM
Cc1cc(F)c(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2nc(N)ncc2c1 CHEMBL213428 IC50 0.9 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1C(=O)Nc1cnc(Nc2cccc(NC(=O)CCN(C)C)c2)nc1 CHEMBL3290125 IC50 0.9 nM
NC(=O)c1c(-c2ccc(NCc3c(Cl)cccc3Cl)cc2)[nH]c(C(=O)c2c(F)cccc2F)c1N CHEMBL590604 C50 0.92 nM
CN(C)CCOc1ccc2c(c1)CCn1nc(-c3ccc(NC(=O)Nc4c(Cl)cccc4Cl)cc3)c(C(N)=O)c1N2 CHEMBL582959 IC50 0.94 nM
CNN1CCN(Cc2ccnc(Nc3nc4ccc(C(=O)Nc5c(C)cccc5Cl)cc4s3)c2)CC1 CHEMBL86939 IC50 1.0 nM
Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3cc(CN4CCOCC4)ccn3)sc2c1 CHEMBL315643 IC50 1.0 nM
Cc1cccc(Cl)c1Nc1nc2ccc(N3CCN(C)CC3)cc2n2cncc12 CHEMBL108907 IC50 1.0 nM
COc1ccccc1N(C(=O)Oc1c(C)cccc1C)c1ccnc(Nc2ccc(N3CCN(C)CC3)cc2)n1 CHEMBL211460 IC50 1.0 nM
Cc1cccc(C)c1OC(=O)N(c1ccnc(Nc2ccc(N3CCN(C)CC3)cc2)n1)c1ccc(F)cc1OC(C)C CHEMBL263769 IC50 1.0 nM
COc1ccc(OC)c(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3ccc(N4CCN(C)CC4)cc3)n2)c1 CHEMBL442485 IC50 1.0 nM
COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3ccc(N4CCN(C)CC4)c(OC)c3)n2)c(OC)c1 CHEMBL215730 IC50 1.0 nM
COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3cc(OC)c(N4CCN(C)CC4)c(OC)c3)n2)c(OC)c1 CHEMBL385898 IC50 1.0 nM
COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3ccc(N4CCN(C)CC4)c(F)c3)n2)c(OC)c1 CHEMBL211845 IC50 1.0 nM
COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3ccc(OCCN(C)C)cc3)n2)c(OC)c1 CHEMBL212721 IC50 1.0 nM
COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3ccc(OCCCN(C)C)cc3)n2)c(OC)c1 CHEMBL214775 IC50 1.0 nM
COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3ccc(OCCN4CCN(C)CC4)cc3)n2)c(OC)c1 CHEMBL212668 IC50 1.0 nM
COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3cc(OC)c(OCCN4CCN(C)CC4)c(OC)c3)n2)c(OC)c1 CHEMBL212143 IC50 1.0 nM
COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3cc(OC)c(OCCN4CCOCC4)c(OC)c3)n2)c(OC)c1 CHEMBL264803 IC50 1.0 nM
COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3ccc(OCCN4CCCCC4)cc3)n2)c(OC)c1 CHEMBL379733 IC50 1.0 nM
COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3ccc(OCCCN4CCN(C)CC4)c(OC)c3)n2)c(OC)c1 CHEMBL379080 IC50 1.0 nM
COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3ccc(OCCCN4CCN(C)CC4)c(F)c3)n2)c(OC)c1 CHEMBL215289 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2C)cc1-c1ccc2nc(Nc3ccccc3)ncc2c1 CHEMBL215863 IC50 1.0 nM
CNc1ncc2cc(-c3cc(C(=O)Nc4ccc(OC5CCN(C)CC5)cc4)ccc3C)ccc2n1 CHEMBL427226 IC50 1.0 nM
Cc1cc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)nc(C)n1 CHEMBL364623 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1C#Cc1cnc(N)nc1 CHEMBL427998 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1C#Cc1cnc2ccccc2c1 CHEMBL219584 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1C#Cc1ccc(N)nc1 CHEMBL220874 IC50 1.0 nM
COc1cc(Nc2ncnc(-n3c(Nc4c(C)cccc4C)nc4ccccc43)n2)cc(OC)c1OC CHEMBL270692 IC50 1.0 nM
COc1cc2nccc(Oc3ccc4c(c3)OCCN4C(=O)Nc3cccc(C)c3)c2cc1OC CHEMBL270057 IC50 1.0 nM
CC(Nc1nccc(-n2cnc3ccccc32)n1)C1CCCN(C(=O)Nc2cccc3ccccc23)C1 CHEMBL567885 IC50 1.0 nM
CCN1CCN(c2ccc3c(c2)ncn3-c2ccnc(N[C@@H](C)c3ccccc3)n2)C1=O CHEMBL566373 IC50 1.0 nM
C[C@H](Nc1nccc(-n2cnc3ccccc32)n1)[C@]1(C)CN(C(=O)Nc2cccc3ccccc23)CCN1C CHEMBL567029 IC50 1.0 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn2c1Nc1cc(OCC(=O)O)ccc1CC2 CHEMBL605724 IC50 1.0 nM
CN(C)CCCOc1ccc2c(c1)CCn1nc(-c3ccc(Oc4ccccc4)cc3)c(C(N)=O)c1N2 CHEMBL591326 IC50 1.0 nM
CN(C)CCOc1ccc2c(c1)CCn1nc(-c3ccc(NCc4c(Cl)cccc4Cl)cc3)c(C(N)=O)c1N2 CHEMBL595401 IC50 1.0 nM
CNC(=O)C(C)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(C)cc5)cc4)csc23)cn1 CHEMBL1970142 pKi 1.0 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(OC(F)F)cc5)cc4)csc23)cn1 CHEMBL1988387 pKi 1.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)c1 CHEMBL1967116 pKi 1.0 nM
C=CC(=O)N[C@H]1CC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 CHEMBL3647967 IC50 1.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 1.01 nM
Cc1cc(Nc2nc3ccc(C(=O)Nc4c(C)cccc4Cl)cc3s2)nc(NCCO)n1 CHEMBL88009 IC50 1.1 nM
CN1CCN(CCOc2ccc3c(c2)CCn2nc(-c4ccc(Oc5ccccc5)cc4)c(C(N)=O)c2N3)CC1 CHEMBL603859 IC50 1.1 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 1.1 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)[nH]c(C(=O)c2c(F)cccc2F)c1N CHEMBL589630 IC50 1.1 nM
Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2ccccn2)s1 CHEMBL189776 IC50 1.2 nM
Cc1cccc(C)c1NC(=O)c1cnc(Nc2ccccn2)s1 CHEMBL386745 IC50 1.2 nM
CN(C)CCOc1ccc2c(c1)Nc1c(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)nn1CC2 CHEMBL591322 IC50 1.2 nM
NC(=O)COc1ccc2c(c1)CCn1nc(-c3ccc(Oc4ccccc4)cc3)c(C(N)=O)c1N2 CHEMBL603737 IC50 1.2 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)[nH]c(C(=O)c2cccc(Cl)c2Cl)c1N CHEMBL593426 C50 1.2 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 CHEMBL49120 pKi 1.259 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4ccc(OC(F)F)cc4)cc3)c12 CHEMBL1972220 pKi 1.259 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCOCC2)n1 CHEMBL217039 IC50 1.3 nM
Cc1ccc(NC(=O)c2ccc3c(c2)OC(F)(F)O3)cc1C(=O)Nc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1 CHEMBL271141 IC50 1.3 nM
COc1ccccc1-n1c(-c2cc(O)ccc2C)cn2c3c(=O)[nH]c(=O)n(C)c3nc12 CHEMBL566515 IC50 1.3 nM
COc1cc(OC)cc(C(=O)Nc2ccc(C)c(C(=O)Nc3cnc(Nc4ccc(N5CCN(C)CC5)cc4)nc3)c2)c1 CHEMBL272850 IC50 1.4 nM
Cc1ccc(NC(=O)c2ccc(C(C)(C)C)cc2)cc1C(=O)Nc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1 CHEMBL405401 IC50 1.5 nM
C[C@H](Nc1nccc(-n2cnc3cc(-c4ccnc(N)n4)ccc32)n1)c1ccccc1 CHEMBL565933 IC50 1.5 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn2c1Nc1cc(OCCO)ccc1CC2 CHEMBL592261 IC50 1.5 nM
NC(=O)COc1ccc2c(c1)Nc1c(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)nn1CC2 CHEMBL591559 IC50 1.5 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)[nH]c(C(=O)c2ccccc2F)c1N CHEMBL591565 C50 1.5 nM
C=CC(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL4109796 IC50 1.56 nM
C=CC(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL3910496 IC50 1.56 nM
CCOc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)cc1 CHEMBL1974254 pKi 1.585 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1970317 pKi 1.585 nM
Cn1cc(-c2cnn3c(N)c(-c4ccc(NC(=O)Nc5cccc(C(F)(F)F)c5)cc4)cnc23)cn1 CHEMBL1988717 pKi 1.585 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(O)CO)c5)cnc(N)c34)cc2)cc1 CHEMBL1965170 pKi 1.585 nM
COc1cc2c(cc1NCCN(C)C)nc(Nc1c(C)cccc1Cl)c1cncn12 CHEMBL108362 IC50 1.7 nM
CN1CCN(c2ccc(Nc3ncc(NC(=O)c4cc(NC(=O)c5ccc6c(c5)OC(F)(F)O6)ccc4Cl)cn3)cc2)CC1 CHEMBL271154 IC50 1.8 nM
CCCCCCN1CCN(C(=O)Nc2cccc3ccccc23)C[C@H]1[C@H](C)Nc1nccc(-n2cnc3ccccc32)n1 CHEMBL567592 IC50 1.8 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)[nH]c(C(=O)c2ccccc2Cl)c1N CHEMBL591566 C50 1.8 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)[nH]c(C(=O)c2c(F)cc(F)cc2F)c1N CHEMBL589144 C50 1.8 nM
Cc1ccc(C(=O)c2[nH]c(-c3ccc(Oc4ccccc4)cc3)c(C(N)=O)c2N)c(C)c1 CHEMBL589868 C50 1.8 nM
CCN1CCN(c2ccc(Nc3nccc(-c4c(-c5cccc(C(=O)Nc6ccccc6F)c5)nc5ccccn45)n3)cc2)CC1 CHEMBL1981725 pKi 1.995 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 pKi 1.995 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2C1CCCC1 CHEMBL47940 IC50 2.0 nM
CC(C)(C)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL302281 IC50 2.0 nM
COc1ccc2c(nc(Nc3c(C)cccc3Cl)c3cncn32)c1OC CHEMBL29320 IC50 2.0 nM
CCN(CC)c1cccc2c1nc(Nc1c(C)cccc1Cl)c1cncn12 CHEMBL85835 IC50 2.0 nM
COc1cc2nc(Nc3c(C)cccc3Cl)c3cncn3c2cc1OC CHEMBL85629 IC50 2.0 nM
CC(=O)NCCNc1cccc(Nc2nc3ccc(C(=O)Nc4c(C)cccc4Cl)cc3s2)n1 CHEMBL86690 IC50 2.0 nM
Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3cccc(N)n3)sc2c1 CHEMBL313384 IC50 2.0 nM
CCN(CC)c1ccc2nc(Nc3c(C)cccc3Cl)c3cncn3c2c1 CHEMBL108686 IC50 2.0 nM
CCN1CCN(c2ccc3nc(Nc4c(C)cccc4Cl)c4cncn4c3c2)CC1 CHEMBL107048 IC50 2.0 nM
CNc1cc(Nc2nc3ccc(C(=O)Nc4c(C)cccc4Cl)cc3s2)ncn1 CHEMBL90002 IC50 2.0 nM
Cc1c(/C=C/CN)nc(O)c2c1ccc1nc(Nc3c(Cl)cccc3Cl)n(C)c12 CHEMBL30230 IC50 2.0 nM
CCNC/C=C/c1nc(O)c2c(ccc3nc(Nc4c(Cl)cccc4Cl)n(C)c32)c1C CHEMBL27350 IC50 2.0 nM
Cc1c(/C=C/CN2CCCC2)nc(O)c2c1ccc1nc(Nc3c(Cl)cccc3Cl)n(C)c12 CHEMBL432089 IC50 2.0 nM
COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3ccc(N4CCN(C)CC4)cc3)n2)c(OC)c1 CHEMBL213100 IC50 2.0 nM
COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3ccc(OCCCN4CCCCC4)c(F)c3)n2)c(OC)c1 CHEMBL215411 IC50 2.0 nM
CCN(CC)CCOc1ccc(Nc2ncc3c(n2)N2CCC(=O)N2C(c2c(Cl)cccc2Cl)=C3)cc1 CHEMBL379517 IC50 2.0 nM
CNc1ncc2cc(-c3cc(C(=O)Nc4cc(C(F)(F)F)ccc4N4CC(C)(C)C4=O)ccc3C)ccc2n1 CHEMBL385055 IC50 2.0 nM
CNc1ncc2cc(-c3cc(C(=O)Nc4cc(C(F)(F)F)ccc4N4CCN(C)C4=O)ccc3C)ccc2n1 CHEMBL385598 IC50 2.0 nM
CN(C)CCOc1ccc2c(c1)CCn1nc(-c3ccc(NC(=O)OCc4ccccc4)cc3)c(C(N)=O)c1N2 CHEMBL595625 IC50 2.0 nM
COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C(F)(F)F)on4)c3)c2cc1OC CHEMBL2029988 Kd 2.0 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL1873475 IC50 2.0 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12 CHEMBL400402 Kd apparent 2.0 nM
CC#CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL4106607 IC50 2.07 nM
CC#CC(=O)N1CCC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL3929922 IC50 2.07 nM
CN[C@H]1CC2OC([C@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(O)=NC4 CHEMBL3975634 IC50 2.21 nM
COc1ccc2c(c1)CCn1nc(-c3ccc(Oc4ccccc4)cc3)c(C(N)=O)c1N2 CHEMBL592259 IC50 2.3 nM
CN(C)CCOc1ccc2c(c1)CCn1nc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c(C(N)=O)c1N2 CHEMBL592267 IC50 2.3 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)[nH]c(C(=O)c2ccc(Cl)cc2Cl)c1N CHEMBL589867 C50 2.3 nM
COc1ccc(C(=O)NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]c(C)c(C(=O)NCCN3CCCC3)c2C)c(F)c1 CHEMBL3329684 IC50 2.3 nM
COc1ccc2c(nc(Nc3c(C)cccc3C)c3cncn32)c1OC CHEMBL281035 IC50 2.4 nM
COc1cc2nc(Nc3c(C)cccc3C)c3cncn3c2cc1OC CHEMBL85920 IC50 2.4 nM
COc1cc2c(cc1OCCN1CCOCC1)nc(Nc1c(C)cccc1Cl)c1cncn12 CHEMBL106457 IC50 2.4 nM
CN(C)C/C=C/C(=O)N1CCCC1Cn1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL3903870 IC50 2.43 nM
Cc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C[C@H]1CCCN1C(=O)/C=C/CN(C)C CHEMBL4107818 IC50 2.43 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)[nH]c(C(=O)c2ccccc2Br)c1N CHEMBL591798 C50 2.5 nM
O=C(Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCCC4=O)c3)n2)c1)c1c(F)cccc1F CHEMBL2006715 pKi 2.512 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccc(CO)cc3)cc1)cn2C1CCOC1 CHEMBL1976376 pKi 2.512 nM
CC(C)(C(N)=O)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1967720 pKi 2.512 nM
CC(Nc1nccc(-n2cnc3ccccc32)n1)C1CN(C(=O)Nc2cccc3ccccc23)CCN1Cc1ccccc1 CHEMBL572199 IC50 2.6 nM
Cc1cccc(C(=O)c2[nH]c(-c3ccc(Oc4ccccc4)cc3)c(C(N)=O)c2N)c1C CHEMBL590843 C50 2.6 nM
CN(C)C/C=C/C(=O)N1CCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 CHEMBL3917698 IC50 2.6 nM
Cc1ccccc1C(=O)c1[nH]c(-c2ccc(Oc3ccccc3)cc2)c(C(N)=O)c1N CHEMBL591799 C50 2.7 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn2c1Nc1ccc(OCc3cccnc3)cc1CC2 CHEMBL600873 IC50 2.8 nM
Cc1ccc(C(=O)c2[nH]c(-c3ccc(Oc4ccccc4)cc3)c(C(N)=O)c2N)cc1 CHEMBL592750 C50 2.8 nM
CC(=O)Nc1cccc2c1nc(Nc1c(C)cccc1Cl)c1cncn12 CHEMBL85637 IC50 3.0 nM
COc1cccc2c1nc(Nc1c(C)cccc1Cl)c1cncn12 CHEMBL315272 IC50 3.0 nM
COc1ccc2nc(Nc3c(C)cccc3Cl)c3cncn3c2c1 CHEMBL86230 IC50 3.0 nM
Cc1cccc(Cl)c1Nc1nc2ccc(N3CC(C)NC(C)C3)cc2n2cncc12 CHEMBL109157 IC50 3.0 nM
Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3ccnc(NCCO)n3)sc2c1 CHEMBL431986 IC50 3.0 nM
COc1cc2c(cc1NCCN(C)C)nc(Nc1c(C)cccc1Cl)c1cnc(C)n12 CHEMBL106213 IC50 3.0 nM
Cc1cccc(Cl)c1Nc1nc2ccc(N3CCNCC3)cc2n2cncc12 CHEMBL110622 IC50 3.0 nM
Cc1cccc(Cl)c1Nc1nc2ccc(NCCCN3CCOCC3)cc2n2cncc12 CHEMBL325986 IC50 3.0 nM
CC(=O)Nc1ccc2nc(Nc3c(C)cccc3Cl)c3cncn3c2c1 CHEMBL110732 IC50 3.0 nM
Cc1cccc(Cl)c1NC(=O)c1ccc2nc(NC(=O)C3CC3CO)sc2c1 CHEMBL68261 IC50 3.0 nM
Cc1c(/C=C/CN(C)C)nc(O)c2c1ccc1nc(Nc3c(Cl)cccc3Cl)n(C)c12 CHEMBL287175 IC50 3.0 nM
CCN(CC)CCOc1ccc(Nc2cc(N(C)C(=O)Nc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)ncn2)cc1 CHEMBL378410 IC50 3.0 nM
CCN(CC)CCOc1ccc(Nc2cc(N(C)C(=O)Nc3cc(O)ccc3C)ncn2)cc1 CHEMBL206873 IC50 3.0 nM
O=C1CCN2c3nc(Nc4ccc(N5CCOCC5)cc4)ncc3C=C(c3c(Cl)cccc3Cl)N12 CHEMBL213745 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2C)cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1 CHEMBL213290 IC50 3.0 nM
CNc1ncc2cc(-c3cc(C(=O)Nc4ccc(Cl)c(C(F)(F)F)c4C)ccc3C)ccc2n1 CHEMBL212183 IC50 3.0 nM
Cc1cc(C)c(NC(=O)c2cnc(Nc3cc(C)nc(C)n3)s2)c(C)c1 CHEMBL384307 IC50 3.0 nM
CCN(CC)CCNc1cc(Nc2cc(O)ccc2C)nc(-n2cnc3ccccc32)n1 CHEMBL434369 IC50 3.0 nM
Cc1ccc(O)cc1Nc1cc(OCCN2CCOCC2)nc(-n2cnc3ccccc32)n1 CHEMBL220645 IC50 3.0 nM
Cc1ccc(O)cc1Nc1cc(N2CCN(C)CC2)nc(-n2cnc3ccccc32)n1 CHEMBL220643 IC50 3.0 nM
C[C@H](Nc1nccc(-n2cnc3cc(-c4ccncc4)ccc32)n1)c1ccccc1 CHEMBL584721 IC50 3.0 nM
Cc1ccc(NC(=O)c2cc(N3CCN(C)CC3)cc(C(F)(F)F)c2)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 CHEMBL1076436 IC50 3.0 nM
CC(=O)Nc1cc(Oc2ccc3c(c2)nc(Nc2cccc(C(C)(C)C)c2)n3C)ccn1 CHEMBL3335371 IC50 3.0 nM
CC(O)Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL2002165 pKi 3.162 nM
O=C1Nc2ccccc2/C1=C/c1c[nH]nc1-c1ccccc1[N+](=O)[O-] CHEMBL2347053 IC50 3.3 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1ncccc1-c1ccncn1 CHEMBL385956 IC50 3.5 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)[nH]c(C(=O)c2ccccc2C(F)(F)F)c1N CHEMBL600273 C50 3.5 nM
Cc1cccc(Cl)c1CNc1ccc(-c2[nH]c(C(=O)c3c(F)cccc3F)c(N)c2C(N)=O)cc1 CHEMBL590605 C50 3.6 nM
CC#CC(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL3905432 IC50 3.82 nM
CC(=O)COc1ccc2c(c1)Nc1c(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)nn1CC2 CHEMBL592507 IC50 3.9 nM
CN(C)CCOc1ccc2c(c1)CCn1nc(-c3ccc(N)cc3)c(C(N)=O)c1N2 CHEMBL604694 IC50 3.9 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 3.9 nM
O=C(c1ccc(Oc2ccccc2)cc1Cl)c1c[nH]c2ncnc(NC3CC[C@@H](CO)OC3)c12 CHEMBL5280844 IC50 3.9 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C(C)C(=O)N(C)C)c5)cnc(N)c34)cc2)cc1 CHEMBL2001485 pKi 3.981 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)O)c5)cnc(N)c34)cc2)c1 CHEMBL1989708 pKi 3.981 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)(C)O)c5)cnc(N)c34)cc2)cc1 CHEMBL2004290 pKi 3.981 nM
COc1cc(-c2nn([C@H]3CC[C@H](N4CCN(C)CC4)CC3)c3ncnc(N)c23)ccc1NC(=O)OCc1ccccc1 CHEMBL47787 IC50 4.0 nM
Cc1cccc(Cl)c1Nc1nc2c(N3CCOCC3)cccc2n2cncc12 CHEMBL314049 IC50 4.0 nM
Cc1cccc(Cl)c1Nc1nc2c(O)c(O)ccc2n2cncc12 CHEMBL86045 IC50 4.0 nM
N#Cc1c(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc2n1C1CCCC1 CHEMBL68888 IC50 4.0 nM
Cc1cccc(Cl)c1Nc1nc2cc3c(cc2n2cncc12)OCO3 CHEMBL320280 IC50 4.0 nM
Cc1cccc(Cl)c1Nc1nc2ccc(N3CCOCC3)cc2n2cncc12 CHEMBL320967 IC50 4.0 nM
Cc1cccc(Cl)c1NC(=O)c1ccc2nc(NC(=O)NC(C)(C)C)sc2c1 CHEMBL67237 IC50 4.0 nM
Cc1cccc(Cl)c1Nc1nc2cc(O)c(O)cc2n2cncc12 CHEMBL110220 IC50 4.0 nM
Cc1cccc(Cl)c1NC(=O)c1ccc2nc(NC(=O)NC3CC(C)(C)NC(C)(C)C3)sc2c1 CHEMBL68871 IC50 4.0 nM
Cc1c(/C=C/CN2CCOCC2)nc(O)c2c1ccc1nc(Nc3c(Cl)cccc3Cl)n(C)c12 CHEMBL424220 IC50 4.0 nM
CCN(CC)CCOc1ccc(Nc2cc(N(C)C(=O)Nc3cc(C(=O)Nc4cc(C(C)(C)C)on4)ccc3C)ncn2)cc1 CHEMBL378882 IC50 4.0 nM
Cc1ccc(O)cc1NC(=O)N(C)c1cc(Nc2ccc(N3CCOCC3)cc2)ncn1 CHEMBL383275 IC50 4.0 nM
Cc1cc(C)nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)c1 CHEMBL188478 IC50 4.0 nM
Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2cccnn2)s1 CHEMBL407005 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1C#Cc1cnc2ccccc2n1 CHEMBL221019 IC50 4.0 nM
COc1cc2nccc(Oc3ccc4c(c3)OCCN4C(=O)Nc3cccc(Cl)c3)c2cc1OC CHEMBL272878 IC50 4.0 nM
CN1CCN(CCOc2cc(OC3CCOCC3)c3c(Nc4c(Cl)ccc5c4OCO5)ncnc3c2)CC1 CHEMBL217092 IC50 4.0 nM
Cc1cccc(C(=O)c2[nH]c(-c3ccc(Oc4ccccc4)cc3)c(C(N)=O)c2N)c1 CHEMBL592513 C50 4.0 nM
CCN1CCN(Cc2ccc(C(=O)Nc3ccc(C)c(Nc4nc5ccccc5n4-c4cc(N)ncn4)c3)cc2Cl)CC1 CHEMBL1076433 IC50 4.0 nM
Cc1ccc(NC(=O)c2ccc(C(C)(C)C)s2)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 CHEMBL1086731 IC50 4.0 nM
CCN1CCN(c2cc(C(=O)Nc3ccc(C)c(Nc4nc5ccccc5n4-c4cc(N)ncn4)c3)cc(C(F)(F)F)c2)CC1 CHEMBL1076437 IC50 4.0 nM
CN1CCN(c2cccc(-c3cnn4c(N)c(-c5ccc(NC(=O)CCC6CCCC6)cc5)cnc34)c2)CC1 CHEMBL1085316 IC50 4.0 nM
CN1CCN(c2ccc(-c3cnn4c(N)c(-c5ccc(NC(=O)CCC6CCCC6)cc5)cnc34)cc2)CC1 CHEMBL1083001 IC50 4.0 nM
COc1cccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)cn2)c1 CHEMBL3290120 IC50 4.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1C(=O)Nc1cnc(Nc2cccc(F)c2)nc1 CHEMBL3290121 IC50 4.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1C(=O)Nc1cnc(Nc2ccc(N)cc2)nc1 CHEMBL3290122 IC50 4.0 nM
Cc1ccc(O)cc1Nc1nccc(-c2noc3ccccc23)n1 CHEMBL220551 IC50 4.2 nM
COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)cc(NS(C)(=O)=O)c4OC)c4ccccc34)ccn2)ccc1C(=O)O CHEMBL3915286 Kd 4.2 nM
COc1ccc2c(nc(Nc3c(C)cccc3Cl)c3cnc(/C=N/O)n32)c1OC CHEMBL29191 IC50 4.3 nM
COc1ccc2c(c1)Nc1c(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)nn1CC2 CHEMBL592026 IC50 4.8 nM
Cc1cc(C)c(NC(=O)c2cnc(Nc3cnccn3)s2)c(C)c1 CHEMBL385172 IC50 4.9 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2C1CCC(O)C1 CHEMBL69129 IC50 5.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2C1CC(O)C(O)C1 CHEMBL69827 IC50 5.0 nM
Cc1cccc(Cl)c1Nc1nc2c(N(C)C)cccc2n2cncc12 CHEMBL315066 IC50 5.0 nM
CC(C)n1cc(-c2ccc(Oc3ccccc3N)cc2)c2c(N)ncnc21 CHEMBL303195 IC50 5.0 nM
Cc1ccc(-c2nn(C(C)(C)C)c3ncnc(N)c23)cc1 CHEMBL306380 IC50 5.0 nM
COc1cc2c(cc1NCCN(C)C)nc(Nc1c(F)cccc1Cl)c1cncn12 CHEMBL321862 IC50 5.0 nM
CCc1cc(Nc2nc3ccc(C(=O)Nc4c(C)cccc4Cl)cc3s2)ncn1 CHEMBL313115 IC50 5.0 nM
Cc1cccc(Cl)c1Nc1nc2ccc(N(C)C)cc2n2cncc12 CHEMBL326476 IC50 5.0 nM
CCc1ccnc(Nc2nc3ccc(C(=O)Nc4c(C)cccc4Cl)cc3s2)c1 CHEMBL86338 IC50 5.0 nM
Cc1cc(C)c(NC(=O)c2cnc(Nc3ccccn3)s2)c(C)c1 CHEMBL386371 IC50 5.0 nM
c1ccc(CCNc2ncnc3oc(-c4ccc(OCCN5CCCC5)cc4)c(-c4ccccc4)c23)cc1 CHEMBL247667 IC50 5.0 nM
COc1cc(Nc2ncc3c(=O)n(-c4c(C)cccc4C)c4nc5ccccc5n4c3n2)ccc1N1CCN(C)CC1 CHEMBL403522 IC50 5.0 nM
COc1ccccc1C(=O)Nc1ccc(C)c(C(=O)Nc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2)c1 CHEMBL409734 IC50 5.0 nM
Cc1ccc(NC(=O)c2ccccc2)cc1C(=O)Nc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1 CHEMBL271760 IC50 5.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1N1Cc2cnc(N)nc2N(C)C1=O CHEMBL459850 EC50 5.0 nM
Cc1nc(NCCN2CCOCC2)cc(Nc2cc(-n3c(Nc4c(C)cccc4Cl)nc4ccccc43)ncn2)n1 CHEMBL450092 IC50 5.0 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)[nH]c(C(=O)c2cccc(F)c2)c1N CHEMBL592511 C50 5.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1nc2ccccc2n1-c1cc(NCCCCN(C)C)ncn1 CHEMBL1076469 IC50 5.0 nM
CN1CCN(c2ccc(-c3cnn4c(N)c(-c5ccc(NC(=O)NCC6CCCCC6)cc5)cnc34)cc2)CC1 CHEMBL1084234 IC50 5.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1C(=O)Nc1cnc(Nc2cccc(N)c2)nc1 CHEMBL3290123 IC50 5.0 nM
C=CC(=O)N1CCC[C@H](n2c(=O)n(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL3991931 Kd apparent 5.0 nM
COc1cc2c(cc1NCCN1CCOCC1)nc(Nc1c(C)cccc1Cl)c1cncn12 CHEMBL322598 IC50 5.4 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn2c1Nc1ccc(OCc3ccccn3)cc1CC2 CHEMBL591091 IC50 5.4 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)[nH]c(C(=O)c2ccc(Br)cc2)c1N CHEMBL607029 C50 5.9 nM
CC#CC(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL4107879 IC50 5.9 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4106978 IC50 5.9 nM
CN(C)C/C=C/C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL3903249 IC50 5.97 nM
Cc1cccc(Cl)c1Nc1nc2cc(N3CCOCC3)ccc2n2cncc12 CHEMBL84046 IC50 6.0 nM
COc1ccccc1Oc1ccc(-c2cn(C3CCCC3)c3ncnc(N)c23)cc1 CHEMBL66102 IC50 6.0 nM
Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3cccc(NCC(C)(C)N)n3)sc2c1 CHEMBL87727 IC50 6.0 nM
Cc1cccc(Cl)c1Nc1nc2ccc(NCCN(C)C)cc2n2cncc12 CHEMBL110654 IC50 6.0 nM
Cc1nc(CN2CCOCC2)cc(Nc2nc3ccc(C(=O)Nc4c(C)cccc4Cl)cc3s2)n1 CHEMBL84846 IC50 6.0 nM
Cc1cc(Nc2nc3ccc(C(=O)Nc4c(C)cccc4Cl)cc3s2)nc(NCC(C)(C)O)n1 CHEMBL87102 IC50 6.0 nM
CC(=O)NCCNc1cc(Nc2nc3ccc(C(=O)Nc4c(C)cccc4Cl)cc3s2)ncn1 CHEMBL89194 IC50 6.0 nM
CN1CCN(c2ccc(Nc3cc(N(C)C(=O)Nc4c(Cl)cccc4Cl)ncn3)cc2)CC1 CHEMBL212632 IC50 6.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2C)cc1-c1ccc2nc(NCCN3CCCC3)ncc2c1 CHEMBL214556 IC50 6.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2C)cc1-c1ccc2nc(NCCN3CCCCC3)ncc2c1 CHEMBL384942 IC50 6.0 nM
CN1CCN(Cc2ccc(-c3oc4ncnc(NC[C@@H]5CCCO5)c4c3-c3ccccc3)cc2)CC1 CHEMBL247677 IC50 6.0 nM
CN(C)CCOc1ccc(-c2oc3ncnc(NC[C@@H]4CCCO4)c3c2-c2ccccc2)cc1 CHEMBL247479 IC50 6.0 nM
COc1cc(Nc2ncc3c(=O)n(-c4c(C)cccc4C)c4nc5ccccc5n4c3n2)cc(OC)c1OCCCN1CCN(C)CC1 CHEMBL260306 IC50 6.0 nM
COc1cc(Nc2ncc3c(=O)n(-c4c(C)cccc4C)c4nc5ccccc5n4c3n2)cc(OC)c1OCCN1CCN(C)CC1 CHEMBL260956 IC50 6.0 nM
COc1cc(Nc2ncnc(-n3c(Nc4ccccc4)nc4ccccc43)n2)cc(OC)c1OC CHEMBL271131 IC50 6.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)c(C)c1C(=O)Nc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1 CHEMBL438016 IC50 6.0 nM
CCc1ccc(NC(=O)c2ccc3c(c2)OC(F)(F)O3)cc1C(=O)Nc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1 CHEMBL270765 IC50 6.0 nM
COc1ccc(CN(C)C)cc1-c1cc2c(Nc3ccc4[nH]ccc4c3C)c(C#N)cnc2s1 CHEMBL516913 IC50 6.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1nc2ccccc2n1-c1cc(NCCCN2CCN(C)CC2)ncn1 CHEMBL1076478 IC50 6.0 nM
CN1CCN(c2cccc(-c3cnn4c(N)c(-c5ccc(NC(=O)NCC6CCCCC6)cc5)cnc34)c2)CC1 CHEMBL1084028 IC50 6.0 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 6.0 nM
COc1cc(C)ccc1Oc1nc(Nc2ccc(N3CCOCC3)cc2)ncc1/N=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL4164968 IC50 6.0 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCCNC(=O)COc3ccc(C4CCC(=O)NC4=O)cc3)CC2)n1 CHEMBL5270900 DC50 6.0 nM
NC(=O)c1c(-c2ccc(OCc3ccccc3)cc2)[nH]c(C(=O)c2c(F)cccc2F)c1N CHEMBL590366 C50 6.1 nM
COc1cc2nc(Nc3c(C)cccc3Cl)c3cnc(CO)n3c2cc1OC CHEMBL314819 IC50 6.2 nM
COc1ccc2c(nc(Nc3c(C)cccc3Cl)c3cnc(CO)n32)c1OC CHEMBL280546 IC50 6.2 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)[nH]c(C(=O)c2cccc(Br)c2)c1N CHEMBL604461 C50 6.2 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 6.2 nM
NC(=O)C[C@H](NC(=O)C1(NC(=O)[C@@H](N)Cc2ccc(OP(=O)(O)O)c(N)c2)CCCCC1)C(N)=O CHEMBL3144403 IC50 6.24 nM
Cc1cnc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)c(C)n1 CHEMBL384545 IC50 6.3 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)[nH]c(C(=O)c2cccc(Cl)c2)c1N CHEMBL592512 C50 6.3 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 6.31 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)csc12 CHEMBL2005631 pKi 6.31 nM
NC(=O)c1c(-c2ccc(NCc3ccccc3)cc2)[nH]c(C(=O)c2c(F)cccc2F)c1N CHEMBL603922 C50 6.4 nM
COc1cc(C)ccc1Oc1nc(Nc2ccc(N3CCOCC3)cc2)ncc1/N=C/c1cc(Cl)cc(Cl)c1 CHEMBL4172630 IC50 6.5 nM
C=CC(=O)N(C)CCn1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL3921017 IC50 6.62 nM
Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2cccnc2)s1 CHEMBL189675 IC50 6.7 nM
Cc1ccc(N)cc1Nc1nccc(-c2noc3ccccc23)n1 CHEMBL220924 IC50 6.8 nM
Cc1cccc(Cl)c1Nc1nc2c(N)cccc2n2cncc12 CHEMBL85974 IC50 7.0 nM
Cc1cccc(Cl)c1Nc1nc2ccc(N)cc2n2cncc12 CHEMBL319199 IC50 7.0 nM
CNCc1cc(Nc2nc3ccc(C(=O)Nc4c(C)cccc4Cl)cc3s2)nc(C)n1 CHEMBL315778 IC50 7.0 nM
Cc1cccc(Cl)c1Nc1nc2ccc(NCCN3CCOCC3)cc2n2cncc12 CHEMBL106654 IC50 7.0 nM
Cc1cccc(Cl)c1NC(=O)c1ccc2nc(NC(=O)C3CC3CN(C)C)sc2c1 CHEMBL309103 IC50 7.0 nM
Cc1cccc(Cl)c1NC(=O)c1ccc2nc(NC(=O)NCCC3CCCN3C)sc2c1 CHEMBL308432 IC50 7.0 nM
Cc1cccc(Cl)c1NC(=O)c1ccc2nc(NC(=O)C3CC3C)sc2c1 CHEMBL68882 IC50 7.0 nM
Clc1ccc2c(c1Nc1ncnc3cc(OCCCN4CCCC4)cc(OC4CCOCC4)c13)OCO2 CHEMBL217090 IC50 7.0 nM
CNc1ncc(C(=O)Nc2cc(C(=O)Nc3cccc(C(F)(F)F)c3F)ccc2C)c(OC)n1 CHEMBL255533 IC50 7.0 nM
Cc1cccc(C)c1-n1c(=O)c2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2n2c3ccccc3nc12 CHEMBL410295 IC50 7.0 nM
Cc1ccc(NC(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2nc(N)ncc2c1 CHEMBL409914 IC50 7.0 nM
COc1cc(Nc2nn3c(N[C@H](CO)Cc4ccccc4)cc(C4CC4)nc3c2C(N)=O)cc(OC)c1 CHEMBL260861 IC50 7.0 nM
Cc1nc(Nc2cc(-n3c(Nc4c(C)cccc4Cl)nc4ccccc43)ncn2)cc(N2CCN(CCO)CC2)n1 CHEMBL447107 IC50 7.0 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)[nH]c(C(=O)c2ccc(Cl)cc2)c1N CHEMBL592749 C50 7.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 CHEMBL1079945 IC50 7.0 nM
Cc1ccc(NC(=O)c2ccncc2C(C)(C)C)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 CHEMBL1080475 IC50 7.0 nM
Cc1ccc(NC(=O)c2cc(OC3CCN(C)CC3)cc(C(F)(F)F)c2)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 CHEMBL1076432 IC50 7.0 nM
Cc1ccc(C(=O)Nc2cccc(C(C)C)c2)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 CHEMBL1087127 IC50 7.0 nM
CC(C)COC(=O)Nc1ccc(-c2cnc3c(-c4cccc(N5CCNCC5)c4)cnn3c2N)cc1 CHEMBL1083644 IC50 7.0 nM
CC(C)COC(=O)Nc1ccc(-c2cnc3c(-c4cccc(N5CCN(C(=O)CN)CC5)c4)cnn3c2N)cc1 CHEMBL1082404 IC50 7.0 nM
Cn1cc(Nc2ncc(Br)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)cn1 CHEMBL2071201 IC50 7.0 nM
CN1CCC(Nc2ccc3c(c2)/C(=C/c2cc4c([nH]2)CCN(C(=O)N2CCOCC2)C4)C(=O)N3)CC1 CHEMBL2403373 IC50 7.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1C(=O)Nc1cnc(Nc2ccccc2)nc1 CHEMBL3290118 IC50 7.0 nM
CCC(=O)Nc1cccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)cn2)c1 CHEMBL3290124 IC50 7.0 nM
Nc1nccn2c([C@@H]3CCCN(C4CCOCC4)C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c12 CHEMBL4077588 IC50 7.0 nM
Cc1ccn(-c2ccc(C(C)(C)C)cc2)c(=O)c1-c1ccc2nc(N)ncc2c1 CHEMBL496494 IC50 7.2 nM
COc1ccc2c(nc(Nc3c(C)cccc3Cl)c3cnc(C)n32)c1OC CHEMBL29858 IC50 7.4 nM
CCN1CCN(c2ccc(Nc3ncc4scc(-c5cccc(NS(C)(=O)=O)c5)c4n3)cc2)CC1 CHEMBL4846921 IC50 7.8 nM
COc1cc(-c2csc3c(C=CC(=O)NCCN(C)C)cnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C CHEMBL1989267 pKi 7.943 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CCO)c5)cnc(N)c34)cc2F)c1 CHEMBL1986851 pKi 7.943 nM
COc1cc(Nc2nccc(Nc3cc(C4CCCCC4)no3)n2)cc(OC)c1OC CHEMBL1984711 pKi 7.943 nM
CCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)csc12 CHEMBL1979516 pKi 7.943 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3O)cc1)cn2C1CCCC1 CHEMBL67268 IC50 8.0 nM
Cc1cccc(Cl)c1Nc1nc2cc(N3CCN(C)CC3)ccc2n2cncc12 CHEMBL108044 IC50 8.0 nM
Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3cc(N)ncn3)sc2c1 CHEMBL89562 IC50 8.0 nM
Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3cc(NCCO)ncn3)sc2c1 CHEMBL89247 IC50 8.0 nM
Cc1cc(C)nc(Nc2nc3ccc(C(=O)Nc4c(C)cccc4Cl)cc3s2)c1 CHEMBL86392 IC50 8.0 nM
CNc1ncc2cc(-c3cc(NC(=O)Nc4cccc(C(F)(F)F)c4)ccc3C)ccc2n1 CHEMBL424719 IC50 8.0 nM
Cc1cccc(C)c1Nc1ncc(-c2ccc(OCC3CCCN(C)C3)cc2)n2cncc12 CHEMBL534948 IC50 8.0 nM
COc1cc(-c2oc3ncnc(NC[C@@H]4CCCO4)c3c2-c2ccccc2)ccc1OCCN1CCCCC1 CHEMBL399212 IC50 8.0 nM
CN1CCN(c2ccc(Nc3ncc4c(=O)n(-c5c(Cl)cc(Cl)cc5Cl)c5nc6ccccc6n5c4n3)cc2)CC1 CHEMBL254674 IC50 8.0 nM
COc1cc2c(Oc3ccc(-c4cnc(Cc5ccccc5)n(C)c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL505896 IC50 8.0 nM
Cc1ccc(NC(=O)c2cc(CN3CCN(C)CC3)n(C(C)(C)C)n2)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 CHEMBL1075628 IC50 8.0 nM
CN1CCN(c2cccc(-c3cnn4c(N)c(-c5ccc(NC(=O)Nc6ccccc6Cl)cc5)cnc34)c2)CC1 CHEMBL1085061 IC50 8.0 nM
CN1CCN(c2cccc(-c3cnn4c(N)c(-c5ccc(NC(=O)N(C)C6CCCCC6)cc5)cnc34)c2)CC1 CHEMBL1084302 IC50 8.0 nM
CN1CCN(c2ccc(-c3cnn4c(N)c(-c5cccc(O)c5)cnc34)cc2)CC1 CHEMBL1083023 IC50 8.0 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCCC(=O)N3CCN(c4ccc(C5CCC(=O)NC5=O)cc4)CC3)CC2)n1 CHEMBL5276245 DC50 8.0 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCCNC(=O)COc3ccc(N4CCC(=O)NC4=O)cc3)CC2)n1 CHEMBL5268757 DC50 8.0 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn2c1Nc1cc(OCc3cccnc3)ccc1CC2 CHEMBL606459 IC50 8.2 nM
COc1ccc2c(c1)nc(Nc1c(C)cccc1Cl)c1cncn12 CHEMBL311309 IC50 8.7 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 IC50 8.9 nM
Clc1cccc(Cl)c1Nc1nc2ccccc2n2cncc12 CHEMBL29457 IC50 9.0 nM
Cc1cccc(Cl)c1Nc1nc2ccccc2n2cncc12 CHEMBL283212 IC50 9.0 nM
CCN(CC)c1ccc2c(c1)nc(Nc1c(C)cccc1Cl)c1cncn12 CHEMBL84877 IC50 9.0 nM
Cc1cccc(Nc2nc3ccc(C(=O)Nc4c(C)cccc4Cl)cc3s2)n1 CHEMBL313912 IC50 9.0 nM
Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3cc(CN(C)C)ccn3)sc2c1 CHEMBL87917 IC50 9.0 nM
Cc1cccc(Cl)c1Nc1nc2cc(NCCCN(C)C)ccc2n2cncc12 CHEMBL110394 IC50 9.0 nM
Cc1cccc(Cl)c1Nc1nc2ccc(N3CCN(C=O)CC3)cc2n2cncc12 CHEMBL110550 IC50 9.0 nM
Cc1cccc(Cl)c1Nc1nc2ccc(N3CCCN(C)CC3)cc2n2cncc12 CHEMBL110783 IC50 9.0 nM
Cc1cccc(Cl)c1NC(=O)c1ccc2nc(NC(=O)C3CC3)sc2c1 CHEMBL67758 IC50 9.0 nM
Cc1c(/C=C/O)nc(O)c2c1ccc1nc(Nc3c(Cl)cccc3Cl)n(C)c12 CHEMBL27485 IC50 9.0 nM
Cc1cccc(Cl)c1NC(=O)N(C)c1cc(Nc2ccc(N3CCN(C)CC3)cc2)ncn1 CHEMBL211283 IC50 9.0 nM
c1ccc(-c2c(-c3ccc(OCCN4CCCC4)cc3)oc3ncnc(NCCN4CCNCC4)c23)cc1 CHEMBL247468 IC50 9.0 nM
CO[n+]1c(Nc2c(C)cccc2Cl)c2cncn2c2ccccc21 CHEMBL313798 IC50 9.4 nM
COc1cccc2nc(Nc3c(C)cccc3Cl)c3cncn3c12 CHEMBL106378 IC50 9.4 nM
Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2ccncc2)s1 CHEMBL360810 IC50 9.4 nM
COc1ccccc1C(=O)c1[nH]c(-c2ccc(Oc3ccccc3)cc2)c(C(N)=O)c1N CHEMBL591094 C50 9.4 nM