O=C1NC(c2ccc(N3CCOCC3)cc2)(c2cccc(Nc3ccc(F)cc3)n2)CC(O)=C1Sc1ccccc1Cl CHEMBL5185237 IC50 1.7 nM
O=C1NC(c2ccc(N3CCOCC3)cc2)(c2cccc(Oc3ccc(F)cc3)n2)CC(O)=C1Sc1ccccc1Cl CHEMBL5201115 IC50 2.2 nM
O=C1NC(c2cccc(Nc3ccc(F)c(F)c3)n2)(c2cccc(NC3CCCCC3)n2)CC(O)=C1Sc1ccccc1Cl CHEMBL5181496 IC50 2.8 nM
O=C1N[C@](c2ccc(N3CCOCC3)cc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl CHEMBL4065858 IC50 5.0 nM
Cc1ccc(C#Cc2cccc(-c3nn(-c4nc(C(=O)O)cs4)c(CC4CC4)c3Cc3ccc(S(N)(=O)=O)c(F)c3)c2)s1 CHEMBL4753379 IC50 5.0 nM
NS(=O)(=O)c1ccc(Cc2c(-c3ccccc3)nn(-c3nc(C(=O)O)cs3)c2CC2CC2)cc1 CHEMBL4059985 IC50 8.0 nM
O=C1NC(c2cccc(Nc3ccc(F)c(F)c3)n2)(c2cccc(NC3CCOCC3)n2)CC(O)=C1Sc1ccccc1Cl CHEMBL5196929 IC50 8.2 nM
Nc1cccc(C2(c3ccsc3)CC(O)=C(Sc3ccccc3Cl)C(=O)O2)c1 CHEMBL5172378 IC50 8.9 nM
O=C1NC(c2cccc(Nc3ccc(F)c(F)c3)n2)(c2cccc(Oc3ccccc3)n2)CC(O)=C1Sc1ccccc1Cl CHEMBL5194549 IC50 9.5 nM
O=C1N[C@](c2cccc(Nc3ccc(F)cc3)n2)(c2cccc(Nc3ccc(F)c(F)c3)n2)CC(O)=C1Sc1ccccc1Cl CHEMBL5183539 IC50 9.8 nM
O=C1OC(c2ccsc2)(c2ccccc2O)CC(O)=C1Sc1ccccc1Cl CHEMBL5181996 IC50 15.0 nM
O=C1OC(c2ccsc2)(c2cccc(Nc3ccc(F)cc3)n2)CC(O)=C1Sc1ccccc1Cl CHEMBL5182266 IC50 17.0 nM
NS(=O)(=O)c1ccc(Cc2c(-c3ccccc3)nn(-c3nc(C(=O)O)cs3)c2C2CC2)cc1 CHEMBL4090677 IC50 20.0 nM
NS(=O)(=O)c1ccc(Cc2c(-c3cccc(-c4ccccc4)c3)nn(-c3nc(C(=O)O)cs3)c2C2CC2)cc1 CHEMBL4100845 IC50 20.0 nM
O=C1NC(c2cccc(Nc3ccc(F)c(F)c3)n2)(c2cccc(Oc3cccc4ncccc34)n2)CC(O)=C1Sc1ccccc1Cl CHEMBL5188480 IC50 25.0 nM
NS(=O)(=O)c1ccc(Cc2c(-c3cccc(-c4ccccc4)c3)nn(-c3nc(C(=O)O)cs3)c2CC2CC2)cc1 CHEMBL4081890 IC50 27.0 nM
O=C1NC(c2ccc(N3CCOCC3)cc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl CHEMBL4436150 IC50 30.0 nM
O=C1NC(c2ccsc2)(c2cccc(Nc3ccc(F)c(F)c3)n2)CC(O)=C1Sc1ccccc1Cl CHEMBL5202219 IC50 34.0 nM
O=C1NC(c2ccsc2)(c2cccc(Nc3ccc(F)cc3)c2)CC(O)=C1Sc1ccccc1Cl CHEMBL4576717 IC50 35.0 nM
CC(=O)N1CCN(c2ccc(C3(c4ccsc4)CC(O)=C(Sc4ccccc4Cl)C(=O)N3)cc2)CC1 CHEMBL4467769 IC50 35.0 nM
COc1ncc(-c2ccc3c(Nc4cc(Oc5cc(F)cc(F)c5)cc(C(=O)O)c4)c(S(=O)(=O)NC4CC4)cnc3c2)c(OC)n1 CHEMBL3335794 IC50 43.0 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](OCc3ccccc3)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCCC(=O)NCCCCC#Cc2cccc(-c3nn(-c4nc(C(=O)O)cs4)c(CC4CC4)c3Cc3ccc(S(N)(=O)=O)cc3)c2)C(C)(C)C)cc1 CHEMBL5416627 IC50 43.0 nM
O=C1NC(c2ccc(N3CCS(=O)(=O)CC3)cc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl CHEMBL4536094 IC50 46.0 nM
O=C1N[C@@](c2cccc(Nc3ccc(F)cc3)n2)(c2cccc(Nc3ccc(F)c(F)c3)n2)CC(O)=C1Sc1ccccc1Cl CHEMBL5189879 IC50 46.0 nM
O=C1O[C@@](c2ccsc2)(c2cccc(Nc3ccc(F)cc3)c2)CC(O)=C1Sc1ccccc1Cl CHEMBL5177632 IC50 47.0 nM
NS(=O)(=O)c1ccc(Cc2cn(-c3nc(C(=O)O)cs3)nc2-c2cccc(-c3ccccc3)c2)cc1 CHEMBL4080497 IC50 49.0 nM
O=C1NC(c2ccc(N3CCCCC3)cc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl CHEMBL4520899 IC50 49.0 nM
CCCc1c(O)c(O)c(C(=O)O)c2cc(Cc3ccccc3)c(C)cc12 CHEMBL126519 Ki 50.0 nM
O=C1NC(c2ccc(N3CCCC3)cc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl CHEMBL4444963 IC50 50.0 nM
CN(C)c1ccc(C2(c3ccsc3)CC(O)=C(Sc3ccccc3Cl)C(=O)N2)cc1 CHEMBL4453059 IC50 55.0 nM
O=C1NC(c2ccc(O)cc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl CHEMBL4521960 IC50 57.0 nM
O=C1NC(c2cccc(NCc3ccc(F)cc3)n2)(c2cccc(Nc3ccc(F)c(F)c3)n2)CC(O)=C1Sc1ccccc1Cl CHEMBL5196259 IC50 57.0 nM
N#CC1CCN(c2ccc(C3(c4ccsc4)CC(O)=C(Sc4ccccc4Cl)C(=O)N3)cc2)CC1 CHEMBL4475593 IC50 60.0 nM
NS(=O)(=O)c1ccc(Cc2c(-c3cccc(-c4ccccc4)c3)nn(-c3nc(C(=O)O)cs3)c2C(F)(F)F)cc1 CHEMBL4101800 IC50 62.0 nM
O=C1OC(c2ccsc2)(c2cccc(Nc3ccc(F)cn3)c2)CC(O)=C1Sc1ccccc1Cl CHEMBL5176448 IC50 65.0 nM
CC1(C)CN(c2ccc(C3(c4ccsc4)CC(O)=C(Sc4ccccc4Cl)C(=O)N3)cc2)CCO1 CHEMBL4543949 IC50 70.0 nM
Nc1c(Cc2ccc(S(N)(=O)=O)cc2)c(-c2cccc(-c3ccccc3)c2)nn1-c1nc(C(=O)O)cs1 CHEMBL4075666 IC50 75.0 nM
COC1CCN(c2ccc(C3(c4ccsc4)CC(O)=C(Sc4ccccc4Cl)C(=O)N3)cc2)CC1 CHEMBL4450897 IC50 75.0 nM
O=C1OC(c2ccccc2)(c2ccccc2O)CC(O)=C1Sc1ccccc1Cl CHEMBL5189798 IC50 75.0 nM
O=C1O[C@](c2ccsc2)(c2cccc(Nc3ccc(F)cc3)c2)CC(O)=C1Sc1ccccc1Cl CHEMBL5197729 IC50 75.0 nM
O=C1NC(c2ccsc2)(c2cccc(NC3CCCCC3)c2)CC(O)=C1Sc1ccccc1Cl CHEMBL4435570 IC50 77.0 nM
NS(=O)(=O)c1ccc(Nc2cn(-c3nc(C(=O)O)cs3)nc2-c2cccc(-c3ccccc3)c2)cc1 CHEMBL4076027 IC50 78.0 nM
O=C1NC(c2ccc(N3CCOCC3=O)cc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl CHEMBL4543194 IC50 80.0 nM
NS(=O)(=O)c1ccc(Nc2cn(-c3nc(C(=O)O)cs3)nc2-c2ccccc2)cc1 CHEMBL4076958 IC50 96.0 nM
CCCc1c(O)c(O)c(C(=O)O)c2cc(C)c(C)cc12 CHEMBL338325 Ki 100.0 nM
NS(=O)(=O)c1ccc(Oc2c(-c3cccc(-c4ccccc4)c3)nn(-c3nc(C(=O)O)cs3)c2C2CC2)cc1 CHEMBL4082867 IC50 119.0 nM
CCOC(=O)Cc1ccc(Cl)c(SC2=C(O)CC(c3c(Cl)ccc(-c4ccccc4)c3Cl)CC2=O)c1 CHEMBL3581204 IC50 120.0 nM
NS(=O)(=O)c1ccc(Cc2cn(-c3nc(C(=O)O)cs3)nc2-c2ccc(F)c(F)c2)cc1 CHEMBL4069796 IC50 129.0 nM
CC(C)Oc1ccc(Cl)c(C2CC(=O)C(Sc3cc(O)ccc3C#N)=C(O)C2)c1Cl CHEMBL3581201 IC50 140.0 nM
O=C1N[C@@](c2ccc(N3CCOCC3)cc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl CHEMBL4589484 IC50 140.0 nM
CC1CN(c2ccc(C3(c4ccsc4)CC(O)=C(Sc4ccccc4Cl)C(=O)N3)cc2)CC(C)O1 CHEMBL4534918 IC50 140.0 nM
O=C1NC(c2ccc(N3CCC4(CC3)COC4)cc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl CHEMBL4557701 IC50 140.0 nM
O=C1NC(c2ccsc2)(c2cccc(NC3CCOCC3)c2)CC(O)=C1Sc1ccccc1Cl CHEMBL4545064 IC50 160.0 nM
O=C1NC(c2cccc(NCCC3CC3)n2)(c2cccc(Nc3ccc(F)c(F)c3)n2)CC(O)=C1Sc1ccccc1Cl CHEMBL5171701 IC50 170.0 nM
CC(C)Oc1ccc(Cl)c(C2CC(=O)C(Sc3cc(O)ccc3Cl)=C(O)C2)c1Cl CHEMBL3581199 IC50 180.0 nM
O=C1NC(c2ccc(C3CCCCC3)cc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl CHEMBL4583899 IC50 180.0 nM
O=C1NC(c2ccsc2)(c2cccc(Oc3ccc(F)cc3)c2)CC(O)=C1Sc1ccccc1Cl CHEMBL4555982 IC50 190.0 nM
Cc1cc2c(C(C)C)c(O)c(O)c(C(=O)O)c2cc1Cc1ccccc1 CHEMBL341463 Ki 200.0 nM
Nc1cccc(C2(c3ccsc3)CC(O)=C(Sc3ccccc3Cl)C(=O)N2)c1 CHEMBL4578904 IC50 200.0 nM
O=C(O)c1cc(-c2ccc(CN(Cc3ccccc3)Cc3ccc(-c4ccc(O)c(C(=O)O)c4)o3)o2)ccc1O CHEMBL5180187 IC50 200.0 nM
O=C1OC(c2ccccc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl CHEMBL5205566 IC50 200.0 nM
NS(=O)(=O)c1ccc(Cc2cn(-c3nc(C(=O)O)cs3)nc2-c2ccccc2)cc1 CHEMBL4090794 IC50 204.0 nM
COc1ccc(C2(c3ccsc3)CC(O)=C(Sc3ccccc3Cl)C(=O)N2)cc1 CHEMBL4437061 IC50 210.0 nM
COc1ncc(-c2ccc3c(Nc4cc(C(=O)O)cc(C5CCCC5)c4)c(S(=O)(=O)NC4CC4)cnc3c2)c(OC)n1 CHEMBL3765327 IC50 220.0 nM
COc1ccc(Cl)c(SC2=C(O)CC(c3c(Cl)ccc(-c4ccncc4)c3Cl)CC2=O)c1 CHEMBL3581203 IC50 230.0 nM
O=C1NC(c2ccsc2)(c2cccc(N3CCOCC3)c2)CC(O)=C1Sc1ccccc1Cl CHEMBL4474069 IC50 250.0 nM
Nc1cccc(C2(c3ccccc3)CC(O)=C(Sc3ccccc3Cl)C(=O)O2)c1 CHEMBL5178518 IC50 250.0 nM
NS(=O)(=O)c1ccc(Cc2c(-c3ccccc3)nn(-c3nc(C(=O)O)cs3)c2-c2cccnc2)cc1 CHEMBL4066429 IC50 259.0 nM
O=C1NC(c2ccsc2)(c2cccc(O)c2)CC(O)=C1Sc1ccccc1Cl CHEMBL4444202 IC50 270.0 nM
CC(=O)Nc1cccc(C2(c3ccsc3)CC(O)=C(Sc3ccccc3Cl)C(=O)O2)c1 CHEMBL5194727 IC50 290.0 nM
C#CCCCC(=O)Nc1ccc(C(=O)c2ccc(NCc3ccc(-c4ccc(O)c(C(=O)O)c4)o3)cc2)cc1 CHEMBL5204083 IC50 300.0 nM
O=C1NC(c2ccc(N3CCN(C4COC4)CC3)cc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl CHEMBL4468333 IC50 390.0 nM
Cc1cc2c(C(C)C)c(O)c(O)c3c2c(c1-c1c(C)cc2c(C(C)C)c(O)c(O)c4c2c1OC4=O)OC3=O CHEMBL110030 Ki 400.0 nM
O=C1OC(c2ccsc2)(c2cccc(NCC(F)(F)F)c2)CC(O)=C1Sc1ccccc1Cl CHEMBL5192632 IC50 400.0 nM
COc1ccc(Cl)c(SC2=C(O)CC(c3c(Cl)ccc(OC(C)C)c3Cl)CC2=O)c1 CHEMBL3581200 IC50 410.0 nM
NS(=O)(=O)c1ccc(Cc2c(-c3cccc(-c4ccccc4)c3)nn(-c3nc(C(=O)O)cs3)c2O)cc1 CHEMBL4063125 IC50 424.0 nM
O=C1NC(c2ccc(C3CC3)cc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl CHEMBL4445937 IC50 480.0 nM
COc1ccc(Cl)c(SC2=C(O)CC(c3c(Cl)ccc(NC4CCOCC4)c3Cl)CC2=O)c1 CHEMBL3581205 IC50 490.0 nM
Cc1cc2c(C)c(O)c(O)c(C(=O)O)c2cc1Cc1ccccc1 CHEMBL435995 Ki 500.0 nM
O=C1OC(c2ccsc2)(c2ccccn2)CC(O)=C1Sc1ccccc1Cl CHEMBL5201671 IC50 540.0 nM
O=C1OC(c2ccccc2)(c2cscn2)CC(O)=C1Sc1ccccc1Cl CHEMBL5176666 IC50 550.0 nM
O=C1OC(c2ccsc2)(c2ccccc2F)CC(O)=C1Sc1ccccc1Cl CHEMBL5170393 IC50 600.0 nM
O=C1NC(c2ccsc2)(c2cccc(OC3CCOCC3)c2)CC(O)=C1Sc1ccccc1Cl CHEMBL4574842 IC50 660.0 nM
Cc1cc2c(C(C)C)c(O)c(O)c(C(=O)O)c2cc1-c1ccc2c(C(C)C)c(O)c(O)c(C(=O)O)c2c1 CHEMBL3765374 Ki 700.0 nM
NS(=O)(=O)c1ccc(Cc2c(-c3ccc(F)c(F)c3)nn(-c3nc(C(=O)O)cs3)c2O)cc1 CHEMBL4076973 IC50 724.0 nM
O=C1NC(c2ccccc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl CHEMBL4530052 IC50 740.0 nM
O=C1NC(c2ccc(N3CCNCC3)cc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl CHEMBL4575930 IC50 780.0 nM
O=C1NC(c2ccsc2)(c2cccc(Br)c2)CC(O)=C1Sc1ccccc1Cl CHEMBL4591832 IC50 800.0 nM
O=C1OC(c2cccs2)(c2cccs2)CC(O)=C1Sc1ccccc1Cl CHEMBL5187919 IC50 810.0 nM
N#Cc1ccccc1SC1=C(O)CC(c2c(Br)cccc2Br)CC1=O CHEMBL3318485 IC50 860.0 nM
NS(=O)(=O)c1ccc(Cc2c(-c3cccc(-c4ccccc4F)c3)nn(-c3nc(C(=O)O)cs3)c2O)cc1 CHEMBL4099443 IC50 911.0 nM
CCCc1c(O)c(O)c(C(=O)O)c2ccc(C)cc12 CHEMBL127327 Ki 1000.0 nM
NS(=O)(=O)c1ccc(Cc2c(-c3cccc(Nc4ccccc4)c3)nn(-c3nc(C(=O)O)cs3)c2CC2CC2)cc1 CHEMBL4877797 IC50 1000.0 nM