Cc1nnc(C#C[C@H](CC(N)=O)NC(=O)[C@@H]2c3ccccc3CN2C(=O)C2(c3ccc(Cl)cc3)CC2)o1 CHEMBL5413711 IC50 0.1 nM
NC(=O)C[C@@H](C#Cc1ccncn1)NC(=O)[C@@H]1c2ccccc2CN1C(=O)C1(c2ccc(Cl)cc2)CC1 CHEMBL5420042 IC50 0.1 nM
Cn1ncc2cccc(-c3ccc(S(=O)(=O)CC(C)(C)C(=O)N[C@H](C#N)CC(N)=O)cc3)c21 CHEMBL4545652 IC50 0.12 nM
Cc1nnc(C#C[C@H](CC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)C2(c3ccc(Cl)s3)CC2)o1 CHEMBL5425743 IC50 0.2 nM
NC(=O)C[C@@H](C#Cc1ccncn1)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(Cl)s2)CC1 CHEMBL5394077 IC50 0.2 nM
NC(=O)C[C@@H](C#Cc1cnccn1)NC(=O)[C@@H]1c2ccccc2CN1C(=O)C1(c2ccc(Cl)cc2)CC1 CHEMBL5402221 IC50 0.2 nM
NC(=O)C[C@@H](C#Cc1ccncn1)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL5402155 IC50 0.2 nM
NC(=O)CN(NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1)C(=O)CCl CHEMBL5412556 IC50 0.2 nM
CCOC(=O)/C=C/C(=O)N(CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL5427662 IC50 0.2 nM
Cn1cc2cc(-c3ccc(S(=O)(=O)CC(C)(C)C(=O)N[C@H](C#N)CC(N)=O)cc3)ccc2n1 CHEMBL4438891 IC50 0.26 nM
COc1ccc(-c2ccc(S(=O)(=O)N3CCC[C@H]3C(=O)NN(CC(N)=O)C(=O)CCl)cc2)cc1 CHEMBL5418321 IC50 0.3 nM
Cc1nnc(C#C[C@H](CC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)C2(c3ccc(OC(F)(F)F)cc3)CC2)o1 CHEMBL5415768 IC50 0.3 nM
C#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C1(c2cnn(Cc3ccccc3)c2Cl)CC1 CHEMBL5417499 IC50 0.4 nM
CC(C)(CS(=O)(=O)c1ccccc1-c1ccc2ncsc2c1)C(=O)N[C@H](C#N)CC(N)=O CHEMBL4556228 IC50 0.47 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(OCc3ccc(F)cc3F)cc2)CC1 CHEMBL5399304 IC50 0.5 nM
NC(=O)C[C@@H](C#Cc1ncccn1)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL5419921 IC50 0.6 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(Oc3ccccc3)cc2)CC1 CHEMBL5406157 IC50 0.8 nM
NC(=O)C[C@@H](C#Cc1cccc(C(F)(F)F)n1)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL5409889 IC50 0.8 nM
CCOc1cccc(-c2ccc(COC(=O)N3CCC[C@H]3C(=O)N[C@H](C#N)CC(N)=O)cc2)c1 CHEMBL3264590 IC50 0.9 nM
C#C[C@H](CC(N)=O)NC(=O)[C@@H]1[C@@H]2[C@H](CN1C(=O)C1(c3ccc(OC(F)(F)F)cc3)CC1)C2(C)C CHEMBL5407269 IC50 0.9 nM
NC(=O)CN(NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(Cl)cc2)CCC1)C(=O)CF CHEMBL5427707 IC50 1.0 nM
C#Cc1ccc(C2(C(=O)N3CCC[C@H]3C(=O)NN(CC(N)=O)C(=O)CF)CC2)cc1 CHEMBL5436295 IC50 1.0 nM
COc1ccc(-c2ccc(S(=O)(=O)N3CCC[C@H]3C(=O)NN(CC(N)=O)C(=O)CF)cc2)cc1 CHEMBL5424838 IC50 1.0 nM
C#CCOc1ccc(C2(C(=O)N3CCC[C@H]3C(=O)NN(CC(N)=O)C(=O)CF)CC2)cc1 CHEMBL5396516 IC50 1.0 nM
CC(C)(CS(=O)(=O)c1ccc(-c2cccc(F)c2)cc1)C(=O)N[C@H](C#N)CC(N)=O CHEMBL4549828 IC50 1.3 nM
NC(=O)C[C@@H](C#Cc1cnccn1)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL5398959 IC50 1.3 nM
CC(C)(CS(=O)(=O)c1ccc(-c2ccc(C(C)(C)C)nc2)cc1)C(=O)N[C@H](C#N)CC(N)=O CHEMBL4547118 IC50 1.4 nM
NC(=O)C[C@@H](C#Cc1ncco1)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL5415015 IC50 1.4 nM
C#C[C@H](CC(N)=O)NC(=O)[C@@H]1c2ccccc2CN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL5415184 IC50 1.7 nM
NC(=O)CN(NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1)C(=O)CF CHEMBL5424036 IC50 1.8 nM
NC(=O)C[C@@H](C#Cc1cccnn1)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL5404830 IC50 1.8 nM
C#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@]1(c2ccc(OC(F)(F)F)cc2)C[C@H](OC)C1 CHEMBL5430648 IC50 1.8 nM
C#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(OCC3CCC3(F)F)cc2)CC1 CHEMBL5419035 IC50 2.2 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(-c3ccccc3)cc2)CC1 CHEMBL5406826 IC50 2.8 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL5416023 IC50 2.8 nM
C#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@]1(c2ccc(OC(F)(F)F)cc2)C[C@H](F)C1 CHEMBL5424558 IC50 3.0 nM
COc1cccc(-c2ccc(COC(=O)N3CCC[C@H]3C(=O)N[C@H](C#N)CC(N)=O)cc2)c1 CHEMBL3264589 IC50 3.2 nM
C#C[C@H](CC(N)=O)NC(=O)[C@@H]1C[C@@H](C)CN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL5431473 IC50 3.4 nM
Cn1ncc2cc(-c3ccc(S(=O)(=O)CC(C)(C)C(=O)N[C@H](C#N)CC(N)=O)cc3)ccc21 CHEMBL4474978 IC50 3.6 nM
C#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(Cl)s2)CC1 CHEMBL5399092 IC50 3.9 nM
C#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(OCC3CC3)cc2)CC1 CHEMBL5434439 IC50 4.2 nM
COc1cccc(C#C[C@H](CC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)C2(c3ccc(OC(F)(F)F)cc3)CC2)n1 CHEMBL5425068 IC50 4.3 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)OCc1ccc(-c2ccc(F)cc2)cc1 CHEMBL3264578 IC50 5.0 nM
CC(C)c1ccc(-c2ccc(S(=O)(=O)N3CCC[C@H]3C(=O)N[C@H](C#N)CC(N)=O)cc2)cc1 CHEMBL3741471 IC50 5.0 nM
CC(C)(CS(=O)(=O)c1ccc(-c2ccc(F)cc2)cc1)C(=O)N[C@H](C#N)CC(N)=O CHEMBL4472825 IC50 5.5 nM
COc1ccc(-c2ccc(S(=O)(=O)N3CCC[C@H]3C(=O)N[C@H](C#N)CC(N)=O)cc2)cc1 CHEMBL3740153 IC50 6.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(-c2ccc(Cl)cc2)c(Cl)c1 CHEMBL3740378 IC50 6.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccccc2)CCC1 CHEMBL5401961 IC50 6.4 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(Cl)cc2)CC1 CHEMBL5436644 IC50 6.4 nM
CC(C)(CS(=O)(=O)c1ccc(-c2ccc(Cl)cc2)cc1)C(=O)N[C@H](C#N)CC(N)=O CHEMBL4452627 IC50 7.1 nM
C#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL5399273 IC50 7.2 nM
C#C[C@H](CC(N)=O)NC(=O)[C@@H]1CC2(CC2)CN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL5400935 IC50 7.3 nM
CC(C)Oc1cccc(-c2ccc(COC(=O)N3CCC[C@H]3C(=O)N[C@H](C#N)CC(N)=O)cc2)c1 CHEMBL3264591 IC50 7.8 nM
C#C[C@H](CC(N)=O)NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL5396266 IC50 7.8 nM
C#C[C@H](CC(N)=O)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL5394446 IC50 7.9 nM
C#C[C@H](CC(N)=O)NC(=O)[C@@H]1C[C@H](C)CN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL5420132 IC50 8.5 nM
C#C[C@H](CC(N)=O)NC(=O)[C@@H]1COCCN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL5420681 IC50 8.6 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)OCc1ccc(-c2cccc(Cl)c2)cc1 CHEMBL3264583 IC50 9.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)OCc1ccc(-c2ccc(Cl)nc2)cc1 CHEMBL3264593 IC50 9.0 nM
NC(=O)C[C@@H](C#Cc1ccncc1)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL5408967 IC50 9.4 nM
Cn1ccc2cc(-c3ccc(S(=O)(=O)CC(C)(C)C(=O)N[C@H](C#N)CC(N)=O)cc3)ccc21 CHEMBL4469392 IC50 9.8 nM
NC(=O)C[C@@H](C#Cc1c(F)cccc1F)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL5399981 IC50 9.9 nM
CC(C)(CS(=O)(=O)c1ccc(-c2cncc(C(F)(F)F)c2)cc1)C(=O)N[C@H](C#N)CC(N)=O CHEMBL4516598 IC50 10.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)OCc1ccc(-c2ccc(F)c(F)c2)cc1 CHEMBL3264581 IC50 11.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(C(F)(F)F)cc2)CC1 CHEMBL5433073 IC50 11.0 nM
COc1ccc(C2(C(=O)N3CCC[C@H]3C(=O)N[C@H](C#N)CC(N)=O)CC2)cc1 CHEMBL5435136 IC50 11.2 nM
CC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)COC(=O)c1c(C)cccc1C CHEMBL3954843 IC50 11.5 nM
NC(=O)C[C@@H](C#Cc1ccccn1)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL5430081 IC50 11.8 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(-c2ccccc2)cc1 CHEMBL3740601 IC50 12.0 nM
CC(C)(CS(=O)(=O)c1ccc(-c2ccc(Cl)nc2)cc1)C(=O)N[C@H](C#N)CC(N)=O CHEMBL4517035 IC50 12.0 nM
NC(=O)CN(NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1)C(=O)C(F)Cl CHEMBL5429309 IC50 12.9 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)OCc1ccc(-c2ccc(C(F)(F)F)cc2)cc1 CHEMBL3264587 IC50 15.0 nM
CC(C)(CS(=O)(=O)c1ccc(-c2cncc(Cl)c2)cc1)C(=O)N[C@H](C#N)CC(N)=O CHEMBL4473369 IC50 15.0 nM
Cc1cncc(-c2ccc(S(=O)(=O)CC(C)(C)C(=O)N[C@H](C#N)CC(N)=O)cc2)c1 CHEMBL4462167 IC50 15.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(F)cc2)CC1 CHEMBL5440673 IC50 16.3 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)OCc1ccc(-c2ccccc2)cc1 CHEMBL3264272 IC50 18.0 nM
CC(C)(CS(=O)(=O)c1ccc(-c2ccc(C(F)(F)F)nc2)cc1)C(=O)N[C@H](C#N)CC(N)=O CHEMBL4446264 IC50 18.0 nM
Cc1ccc(C2(C(=O)N3CCC[C@H]3C(=O)N[C@H](C#N)CC(N)=O)CC2)cc1 CHEMBL5423559 IC50 18.4 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(-c2ccc(F)cc2)cc1F CHEMBL3741267 IC50 23.0 nM
Cc1ccc(-c2ccc(S(=O)(=O)CC(C)(C)C(=O)N[C@H](C#N)CC(N)=O)cc2)cn1 CHEMBL4549915 IC50 26.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C1(c2cccc(Cl)c2)CC1 CHEMBL5428991 IC50 27.4 nM
Cc1ccc(-c2ccc(COC(=O)N3CCC[C@H]3C(=O)N[C@H](C#N)CC(N)=O)cc2)cc1 CHEMBL3264274 IC50 28.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)OCc1ccc(-c2cccc(F)c2F)cc1 CHEMBL3264580 IC50 29.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccccc2)CC1 CHEMBL5422570 IC50 29.0 nM
CC(Cl)C(=O)N(CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL5407774 IC50 29.0 nM
CCOC(=O)/C=C/OC(=O)N(CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1 CHEMBL417373 IC50 31.0 nM
C#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C1(n2ncc(C)c2Cl)CC1 CHEMBL5404563 IC50 31.1 nM
Cc1ccc(-c2ccc(S(=O)(=O)N3CCC[C@H]3C(=O)N[C@H](C#N)CC(N)=O)cc2)cc1 CHEMBL3740253 IC50 32.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(-c2ccc(F)cc2)cc1 CHEMBL3739994 IC50 33.0 nM
N#Cc1ccc(-c2ccc(S(=O)(=O)N3CCC[C@H]3C(=O)N[C@H](C#N)CC(N)=O)cc2)cc1 CHEMBL3740368 IC50 33.0 nM
CC(C)(CS(=O)(=O)c1ccc(-c2cccc(F)c2F)cc1)C(=O)N[C@H](C#N)CC(N)=O CHEMBL4520269 IC50 33.0 nM
C#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C1(C(F)(F)F)CC1 CHEMBL5427098 IC50 33.3 nM
CC(C)(CS(=O)(=O)c1ccc(-c2ccccc2F)cc1)C(=O)N[C@H](C#N)CC(N)=O CHEMBL4437001 IC50 34.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccccc2Cl)CC1 CHEMBL5420226 IC50 34.7 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(-c2ccccc2Cl)cc1 CHEMBL3739537 IC50 35.0 nM
C#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@]1(c2ccc(OC(F)(F)F)cc2)C[C@@H](F)C1 CHEMBL5416142 IC50 36.9 nM
C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)NN(CC(N)=O)C(=O)O/C=C/C(=O)OCc1ccccc1 CHEMBL292589 IC50 38.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)OCc1ccc(-c2ccc(F)cc2F)cc1 CHEMBL3264582 IC50 41.0 nM
COc1ccc(-c2ccc(COC(=O)N3CCC[C@H]3C(=O)N[C@H](C#N)CC(N)=O)cc2)cc1 CHEMBL3264588 IC50 41.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(-c2ccc(Cl)cc2)cc1 CHEMBL3741072 IC50 45.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(-c2cccc(F)c2)cc1 CHEMBL3740206 IC50 47.0 nM
Cc1cccc(-c2ccc(COC(=O)N3CCC[C@H]3C(=O)N[C@H](C#N)CC(N)=O)cc2)c1 CHEMBL3264273 IC50 49.0 nM
CC(C)c1cccc(-c2ccc(COC(=O)N3CCC[C@H]3C(=O)N[C@H](C#N)CC(N)=O)cc2)c1 CHEMBL3264276 IC50 49.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(-c2ccc3c(c2)OCO3)cc1 CHEMBL3741002 IC50 49.0 nM
C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)NN(CC(N)=O)C(=O)O/C=C/C(=O)N(C)Cc1ccccc1 CHEMBL54825 IC50 55.0 nM
CC(C)(CS(=O)(=O)c1ccc(-c2ccccc2C(F)(F)F)cc1)C(=O)N[C@H](C#N)CC(N)=O CHEMBL4442344 IC50 59.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)OCc1ccc(-c2cccc(F)c2)cc1 CHEMBL3264577 IC50 60.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)OCc1ccc(-c2cccc(C(F)(F)F)c2)cc1 CHEMBL3264586 IC50 65.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(-c2ccc(F)cc2)c(F)c1 CHEMBL3740166 IC50 67.0 nM
NC(=O)C[C@@H](C#Cc1ccnnc1)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL5394632 IC50 70.0 nM
CCc1ccc(-c2ccc(S(=O)(=O)N3CCC[C@H]3C(=O)N[C@H](C#N)CC(N)=O)cc2)cc1 CHEMBL3742051 IC50 71.0 nM
CC(C)(C)c1ccc(-c2ccc(S(=O)(=O)N3CCC[C@H]3C(=O)N[C@H](C#N)CC(N)=O)cc2)cc1 CHEMBL3741594 IC50 71.0 nM
CCOc1ccc(-c2ccc(S(=O)(=O)N3CCC[C@H]3C(=O)N[C@H](C#N)CC(N)=O)cc2)cc1 CHEMBL3742365 IC50 73.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(Cl)cc1 CHEMBL3740719 IC50 73.0 nM
CC(C)(CS(=O)(=O)c1ccc(-c2cncc(F)c2)cc1)C(=O)N[C@H](C#N)CC(N)=O CHEMBL4538455 IC50 78.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)OCc1ccc(-c2cc(F)cc(F)c2)cc1 CHEMBL3264579 IC50 79.0 nM
CC(C)(CS(=O)(=O)c1ccc(-c2ccc(F)cc2F)cc1)C(=O)N[C@H](C#N)CC(N)=O CHEMBL4438021 IC50 82.0 nM
CC(C)(C)c1cccc(-c2ccc(COC(=O)N3CCC[C@H]3C(=O)N[C@H](C#N)CC(N)=O)cc2)c1 CHEMBL3264278 IC50 83.0 nM
CCOC(=O)C1CCN(c2cc(N3CCOCC3)ccc2N)CC1 CHEMBL5183094 IC50 89.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(-c2cccc(C(F)(F)F)c2)cc1 CHEMBL3741666 IC50 93.0 nM
CC(C)(CS(=O)(=O)c1ccc(-c2ccc(F)nc2)cc1)C(=O)N[C@H](C#N)CC(N)=O CHEMBL4588754 IC50 96.0 nM
CC(C)c1ccc(-c2ccc(COC(=O)N3CCC[C@H]3C(=O)N[C@H](C#N)CC(N)=O)cc2)cc1 CHEMBL3264277 IC50 97.0 nM
NC(=O)C[C@@H](C#Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)C1(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL5436014 IC50 98.2 nM
Cn1c(=O)[nH]c(=O)c2c1nc(S)n2CC(O)COc1ccc(Cl)cc1 CHEMBL4067280 Ki 105.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)OCc1cccc(Br)c1 CHEMBL3264268 IC50 108.0 nM
CC(C)(CS(=O)(=O)c1ccc(-c2cc(F)cc(F)c2)cc1)C(=O)N[C@H](C#N)CC(N)=O CHEMBL4571494 IC50 110.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(-c2ccc(C(F)(F)F)cc2)cc1 CHEMBL3740086 IC50 121.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)OCc1ccc(-c2ccc(Cl)cc2)cc1 CHEMBL3264584 IC50 124.0 nM
C[C@@H](C(=O)N[C@H](C#N)CC(N)=O)N(Cc1ccc(-c2cccc(F)c2)cc1)S(C)(=O)=O CHEMBL3746278 IC50 128.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)OCc1cccc(-c2ccccc2)c1 CHEMBL3264271 IC50 138.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)Cc1ccccc1 CHEMBL5400642 IC50 139.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1 CHEMBL3264594 IC50 140.0 nM
CCn1c(=O)c2c(nc(S)n2C)n(C)c1=O CHEMBL4093898 IC50 160.0 nM
CC(C)Cc1ccc(-c2ccc(S(=O)(=O)CC(C)(C)C(=O)N[C@H](C#N)CC(N)=O)cc2)cc1 CHEMBL4527246 IC50 160.0 nM
CCc1ccc(-c2ccc(COC(=O)N3CCC[C@H]3C(=O)N[C@H](C#N)CC(N)=O)cc2)cc1 CHEMBL3264275 IC50 169.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(-c2ccc(Cl)cc2)cc1Cl CHEMBL3739853 IC50 169.0 nM
Cn1c(S)nc2c1c(=O)n(Cc1ccccc1)c(=O)n2C CHEMBL4074941 IC50 170.0 nM
Cn1c(=O)c2c(nc(S)n2C)n(C)c1=O CHEMBL4092935 IC50 180.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1Br CHEMBL3264267 IC50 192.0 nM
C[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C#N)CC(N)=O)c1ccccc1 CHEMBL5421750 IC50 200.0 nM
C[C@@H](C(=O)N[C@H](C#N)CC(N)=O)N(Cc1ccc(-c2ccc(F)c(F)c2)cc1)S(C)(=O)=O CHEMBL3746674 IC50 252.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(F)cc1 CHEMBL3739555 IC50 269.0 nM
CC(C)(CS(=O)(=O)c1ccc(-c2ccc(Cl)cc2Cl)cc1)C(=O)N[C@H](C#N)CC(N)=O CHEMBL4467572 IC50 280.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)OCc1ccc(Br)cc1 CHEMBL3264269 IC50 282.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(Br)cc1 CHEMBL3741126 IC50 282.0 nM
CC(C)(CS(=O)(=O)c1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)N[C@H](C#N)CC(N)=O CHEMBL4519491 IC50 290.0 nM
C[C@@H](C(=O)N[C@H](C#N)CC(N)=O)N(Cc1ccc(-c2cccc(F)c2F)cc1)S(C)(=O)=O CHEMBL3746873 IC50 323.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(C(F)(F)F)cc1 CHEMBL3739710 IC50 332.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)OCc1ccc(-c2cncc(Cl)c2)cc1 CHEMBL3264592 IC50 343.0 nM
CC(C)(C)c1ccc(-c2ccc(COC(=O)N3CCC[C@H]3C(=O)N[C@H](C#N)CC(N)=O)cc2)cc1 CHEMBL3264576 IC50 348.0 nM
C[C@@H](C(=O)N[C@H](C#N)CC(N)=O)N(Cc1ccc(-c2ccccc2F)cc1)S(C)(=O)=O CHEMBL3746513 IC50 356.0 nM
COc1cccc(-c2ccc(CN([C@@H](C)C(=O)N[C@H](C#N)CC(N)=O)S(C)(=O)=O)cc2)c1 CHEMBL3746972 IC50 378.0 nM
CC(C(=O)N[C@H](C#N)CC(N)=O)N(Cc1ccc(-c2cccc(Cl)c2)cc1)S(C)(=O)=O CHEMBL3745937 IC50 425.0 nM
Nc1ccc(N2CCOCC2)cc1N1CCSCC1 CHEMBL5197937 IC50 498.0 nM
Nc1ccc(N2CCOCC2)cc1N1CCC2(CC1)OCCO2 CHEMBL5194542 IC50 547.0 nM
CCOc1cccc(-c2ccc(CN([C@@H](C)C(=O)N[C@H](C#N)CC(N)=O)S(C)(=O)=O)cc2)c1 CHEMBL3746123 IC50 586.0 nM
N#C[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(Cl)cc1Cl CHEMBL3742218 IC50 593.0 nM
C[C@@H](C(=O)N[C@H](C#N)CC(N)=O)N(Cc1ccc(-c2cccc(C(F)(F)F)c2)cc1)S(C)(=O)=O CHEMBL3746339 IC50 601.0 nM
Nc1ccc(N2CCSCC2)cc1N1CCSCC1 CHEMBL5175987 IC50 757.0 nM
Nc1ccc(N2CCOCC2)cc1N1CCOCC1 CHEMBL5185780 IC50 844.0 nM
CC(C)(CS(=O)(=O)c1ccc(-c2ccc(C(C)(C)C)cc2)cc1)C(=O)N[C@H](C#N)CC(N)=O CHEMBL4555719 IC50 870.0 nM
CC(C)Oc1cccc(-c2ccc(CN([C@@H](C)C(=O)N[C@H](C#N)CC(N)=O)S(C)(=O)=O)cc2)c1 CHEMBL3746549 IC50 882.0 nM
CC(C)Oc1ccc(-c2ccc(S(=O)(=O)N3CCC[C@H]3C(=O)N[C@H](C#N)CC(N)=O)cc2)cc1 CHEMBL3740796 IC50 969.0 nM
CC(C)(C(=O)N1CCC[C@H]1C(=O)N[C@H](C#N)CC(N)=O)c1ccccc1 CHEMBL5431396 IC50 986.0 nM
C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)NN(CC(N)=O)C(=O)O/C=C/C(=O)NCc1ccccc1 CHEMBL55249 IC50 1000.0 nM